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10. Metrics of pN-staging in oral squamous cell carcinoma: An analysis of 1,905 patients

Author

Mirian, Christian, Gerds, Thomas A., Pedersen, Maria M., de Ridder, Mischa, Balm, Alfons, Mattavelli, Davide, Piazza, Cesare, Jensen, Lasse R., Balasubramanian, Deepak, Subramaniam, Narayana, Dokhe, Yogesh, Thankappan, Krishnakumar, Iyer, Subramania, Karam, Sana D., Wiegand, Susanne, Feeley, Linda, Milross, Chris, Gao, Kan, Palme, Carsten E., Low, Tsu-Hui (Hubert), Gupta, Ruta, Freudlsperger, Christian, Moratin, Julius, Sheahan, Patrick, Clark, Jonathan, and Ovesen, Therese

Published
2021
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19. Early vestibular rehabilitation training of peripheral acute vestibular syndrome--a systematic review and meta-analysis.

Author

Agger-Nielsen, Helle Elisabeth, Grøndberg, Thomas Stig, Berg-Beckhoff, Gabriele, and Ovesen, Therese

Subjects
REHABILITATION, SYNDROMES, CINAHL database, EQUILIBRIUM testing, DISABILITIES, VESTIBULAR apparatus diseases
Abstract

Objective: This study aimed to investigate the impact of early vestibular rehabilitation training combined with corticosteroids initiated within 2 weeks, compared with corticosteroid treatment, after the peripheral acute vestibular syndrome (pAVS) onset. Data sources: PubMed, CINAHL, EMBASE, and SCOPUS. From inception to January 24, 2024. The International Prospective Register of Systematic Reviews approved this study (CRD42023422308). Results: Five studies involving 235 patients were included in this systematic review and meta-analysis. The subjective outcome measure Dizziness Handicap Inventory (DHI) was pooled for a meta-analysis and was statistically significantly in favor of early vestibular rehabilitation training (early VRT) plus corticosteroids compared with corticosteroids alone: at one-month follow-up (p = 0.00) and 12 months follow-up (p = 0.01). DHI was a critical outcome for measuring the differences in effect of early VRT. The objective outcome measures of caloric lateralization, cervical vestibular-evoked myogenic potentials, and posturography were gathered for a narrative synthesis. Conclusion: This meta-analysis showed that early VRT in combination with corticosteroids was more effective for treating pAVS than corticosteroid treatment alone. No adverse effects were reported for early VRT. [ABSTRACT FROM AUTHOR]

Published
2024
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20. Autofluorescence-guided hemithyroidectomy in a low-volume thyroid institution with no experience in parathyroid surgery: randomized clinical trial.

Author

Abood, Ali, Rolighed, Lars, Ovesen, Therese, Madsen, Stine H, Vestergaard, Peter, and Triponez, Frédéric

Subjects
THYROIDECTOMY, HEMITHYROIDECTOMY, CLINICAL trials, PARATHYROID glands, THYROID gland, BIOFLUORESCENCE
Abstract

Background: Recent studies suggest that low-volume surgeons with no experience in parathyroid surgery are at increased risk of causing parathyroid gland damage during thyroid surgery. The aim of this RCT was to evaluate the impact of using autofluorescence in hemithyroidectomy on parathyroid gland identification and preservation in a low-volume institution with no experience in parathyroid surgery. Methods: Patients referred for hemithyroidectomy were randomized 1 : 1 to either autofluorescence-guided hemithyroidectomy (the near-infrared autofluorescence group) or conventional hemithyroidectomy (the control group). The primary outcome was parathyroid gland identification rate. Secondary outcomes were the rate of parathyroid gland autotransplantation and the rate of inadvertent parathyroid gland excision. Results: A total of 170 patients were randomized to either autofluorescence-guided hemithyroidectomy (84 patients) or conventional hemithyroidectomy (86 patients). In the near-infrared autofluorescence group, 81.0% of parathyroid glands were identified, compared with 57.0% in the control group (P < 0.001). Autofluorescence enabled parathyroid gland visualization before the naked eye in 46.3% of cases. Surgeons had lower confidence in the parathyroid gland identification process in the control group than in the near-infrared autofluorescence group (59.1% versus 87.5% respectively; P < 0.001). In the near-infrared autofluorescence group, the parathyroid gland autotransplantation rate was initially high, but declined over time. There was no difference in the rate of inadvertent parathyroid gland excision. Conclusion: Autofluorescence guidance significantly improved the parathyroid gland identification rate in hemithyroidectomy in a low-volume institution with no experience in parathyroid surgery and provided an increase in surgical confidence. The pattern of parathyroid gland autotransplantation in autofluorescence-guided surgery indicates the presence of a learning curve. Registration number: NCT05044351 (http://www.clinicaltrials.gov). Lay Summary: Damage to the parathyroid glands is common during thyroid surgery. The main reason for that is that they can be difficult to see during surgery. The aim of this study was to see if the use of a new near-infrared camera during thyroid surgery could make it easier to see the parathyroid glands. Patients, where removal of part of their thyroid gland was planned, were randomly assigned to one of two groups. In the first group, the near-infrared camera was used, whereas it was not used in the other group. When the near-infrared camera was used, more parathyroid glands were found and the surgeons felt more secure in their handling of parathyroid glands. Parathyroid gland damage during thyroid surgery is a common complication, especially among low-volume thyroid surgeons with no experience in parathyroid surgery. In this RCT, the impact of using intraoperative autofluorescence during thyroid surgery on parathyroid gland identification and preservation was evaluated, in a low-volume, non-parathyroid institution. Autofluorescence significantly improved parathyroid gland identification and preservation, making low-volume, non-parathyroid surgeons comparable to high-volume surgeons who also perform parathyroid surgery. [ABSTRACT FROM AUTHOR]

Published
2024
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24. Supplement Methods from RAS–MAPK Reactivation Facilitates Acquired Resistance in FGFR1-Amplified Lung Cancer and Underlies a Rationale for Upfront FGFR–MEK Blockade

Author

Bockorny, Bruno, primary, Rusan, Maria, primary, Chen, Wankun, primary, Liao, Rachel G., primary, Li, Yvonne, primary, Piccioni, Federica, primary, Wang, Jun, primary, Tan, Li, primary, Thorner, Aaron R., primary, Li, Tianxia, primary, Zhang, Yanxi, primary, Miao, Changhong, primary, Ovesen, Therese, primary, Shapiro, Geoffrey I., primary, Kwiatkowski, David J., primary, Gray, Nathanael S., primary, Meyerson, Matthew, primary, Hammerman, Peter S., primary, and Bass, Adam J., primary

Published
2023
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25. Figure S4 from RAS–MAPK Reactivation Facilitates Acquired Resistance in FGFR1-Amplified Lung Cancer and Underlies a Rationale for Upfront FGFR–MEK Blockade

Author

Bockorny, Bruno, primary, Rusan, Maria, primary, Chen, Wankun, primary, Liao, Rachel G., primary, Li, Yvonne, primary, Piccioni, Federica, primary, Wang, Jun, primary, Tan, Li, primary, Thorner, Aaron R., primary, Li, Tianxia, primary, Zhang, Yanxi, primary, Miao, Changhong, primary, Ovesen, Therese, primary, Shapiro, Geoffrey I., primary, Kwiatkowski, David J., primary, Gray, Nathanael S., primary, Meyerson, Matthew, primary, Hammerman, Peter S., primary, and Bass, Adam J., primary

Published
2023
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26. Supplementary Table 3 from RAS–MAPK Reactivation Facilitates Acquired Resistance in FGFR1-Amplified Lung Cancer and Underlies a Rationale for Upfront FGFR–MEK Blockade

Author

Bockorny, Bruno, primary, Rusan, Maria, primary, Chen, Wankun, primary, Liao, Rachel G., primary, Li, Yvonne, primary, Piccioni, Federica, primary, Wang, Jun, primary, Tan, Li, primary, Thorner, Aaron R., primary, Li, Tianxia, primary, Zhang, Yanxi, primary, Miao, Changhong, primary, Ovesen, Therese, primary, Shapiro, Geoffrey I., primary, Kwiatkowski, David J., primary, Gray, Nathanael S., primary, Meyerson, Matthew, primary, Hammerman, Peter S., primary, and Bass, Adam J., primary

Published
2023
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27. Supplementary Table 1, 2 and 4 from RAS–MAPK Reactivation Facilitates Acquired Resistance in FGFR1-Amplified Lung Cancer and Underlies a Rationale for Upfront FGFR–MEK Blockade

Author

Bockorny, Bruno, primary, Rusan, Maria, primary, Chen, Wankun, primary, Liao, Rachel G., primary, Li, Yvonne, primary, Piccioni, Federica, primary, Wang, Jun, primary, Tan, Li, primary, Thorner, Aaron R., primary, Li, Tianxia, primary, Zhang, Yanxi, primary, Miao, Changhong, primary, Ovesen, Therese, primary, Shapiro, Geoffrey I., primary, Kwiatkowski, David J., primary, Gray, Nathanael S., primary, Meyerson, Matthew, primary, Hammerman, Peter S., primary, and Bass, Adam J., primary

Published
2023
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28. Data from RAS–MAPK Reactivation Facilitates Acquired Resistance in FGFR1-Amplified Lung Cancer and Underlies a Rationale for Upfront FGFR–MEK Blockade

Author

Bockorny, Bruno, primary, Rusan, Maria, primary, Chen, Wankun, primary, Liao, Rachel G., primary, Li, Yvonne, primary, Piccioni, Federica, primary, Wang, Jun, primary, Tan, Li, primary, Thorner, Aaron R., primary, Li, Tianxia, primary, Zhang, Yanxi, primary, Miao, Changhong, primary, Ovesen, Therese, primary, Shapiro, Geoffrey I., primary, Kwiatkowski, David J., primary, Gray, Nathanael S., primary, Meyerson, Matthew, primary, Hammerman, Peter S., primary, and Bass, Adam J., primary

Published
2023
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29. Figure S6 and S7 from RAS–MAPK Reactivation Facilitates Acquired Resistance in FGFR1-Amplified Lung Cancer and Underlies a Rationale for Upfront FGFR–MEK Blockade

Author

Bockorny, Bruno, primary, Rusan, Maria, primary, Chen, Wankun, primary, Liao, Rachel G., primary, Li, Yvonne, primary, Piccioni, Federica, primary, Wang, Jun, primary, Tan, Li, primary, Thorner, Aaron R., primary, Li, Tianxia, primary, Zhang, Yanxi, primary, Miao, Changhong, primary, Ovesen, Therese, primary, Shapiro, Geoffrey I., primary, Kwiatkowski, David J., primary, Gray, Nathanael S., primary, Meyerson, Matthew, primary, Hammerman, Peter S., primary, and Bass, Adam J., primary

Published
2023
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30. Cranial Nerve Affection in Adolescents with Type 1 Diabetes Assessed by Corneal Confocal Microscopy, Smell and Taste Tests

Author

Rasmussen, Vinni Faber, primary, Rasmussen, Dorthe, additional, Thrysøe, Mathilde, additional, Karlsson, Páll, additional, Madsen, Mette, additional, Kristensen, Kurt, additional, Nyengaard, Jens Randel, additional, Terkelsen, Astrid Juhl, additional, Vestergaard, Esben Thyssen, additional, and Ovesen, Therese, additional

Published
2023
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33. Validation of the Danish version of the Tinnitus Functional Index

Author

Hald, Mine Onat, Dreyer, Rasmus, Hald, Mathias, Mikkelsen, Sophie, and Ovesen, Therese

Abstract

INTRODUCTION. Consensus about which questionnaire to use is necessary when it comes to evaluation of tinnitus. In Denmark, the Tinnitus Handicap Index is currently used. However, for evaluating treatment-related outcomes, the Tinnitus Functional Index (TFI) has been optimised for this and is being used in several countries. In this study, we aimed to provide validation of a professionally translated Danish version of the TFI to safely implement this questionnaire in clinical and scientific settings. METHODS. At the Department of Audiology at Hospital West Jutland, Denmark, 133 adult patients suffering from tinnitus with or without hearing loss completed the Danish version of the TFI questionnaire (TFI-Da). Internal consistency was evaluated by Cronbach’s alpha and test–retest reliability with Pearson’s correlation. RESULTS. Internal consistency was calculated for the total TFI score producing an excellent Crohnbach’s alpha of 0.96. Crohnbach’s alpha scores were also acceptable for all subgroups with values > 0.7. The test–retest reliability in terms of Pearson’s correlation coefficient was 0.848 for the total TFI scores and was acceptable for all subgroups. CONCLUSION. Our study showed a very high internal consistency and test-retest reliability when using the Danish version of the TFI questionnaire. Therefore, we recommend TFI-Da as the standard questionnaire for tinnitus patients in Denmark, especially for evaluation of treatment impact.

Published
2022

38. Comparison of clinical practice of tonsil surgery from quality register data from Sweden and Norway and one clinic in Denmark

Author

Stalfors, Joacim, Ovesen, Therese, Bertelsen, Jannik Buus, Bugten, Vegard, Wennberg, Siri, Sunnergren, Ola, Stalfors, Joacim, Ovesen, Therese, Bertelsen, Jannik Buus, Bugten, Vegard, Wennberg, Siri, and Sunnergren, Ola

Abstract

Objectives To compare the application of indications, demographics, surgical and haemostatic techniques in tonsil surgery in three countries. Design Non-randomised, prospective, observational cohort. Setting All patients registered in the National Tonsil Surgery Quality Registers in Sweden, Norway and West Jutland, Denmark. Participants Data were retrieved from 2017 to 2019; registered surgeries: Sweden: 20 833; Norway: 10 294 and West Jutland, Denmark: 505. Results Tonsil surgery for obstruction was twice as common in Sweden (62.2%) compared with Norway (31%) and Denmark (27.7%). Recurrent tonsillitis was registered twice as frequently in Norway (35.7%) and Denmark (39%) compared with Sweden (16.7%). Chronic tonsillitis was registered more frequently in Norway (29.8%) than in Sweden (13.8%) and Denmark (12.7%). Day surgery (>76%) was comparable. The higher frequency of obstruction in Sweden affected age and gender distributions: Sweden (7 years, 50.4% boys), Norway (17 y, 42.1%) and Denmark (19 y, 38.4%). For obstructive disorders, tonsillotomy with adenoidectomy was used in a majority of Swedish children (72%), whereas tonsillectomy with or without adenoidectomy dominated in Norway (53.5%) and Denmark (57.9%). Cold steel was the technique of choice for tonsillectomy in all three countries. For tonsillotomy, hot dissection techniques dominated in all countries. Disparities were observed with regard to haemostatic techniques. Bipolar diathermy was commonly used in all countries. Monopolar diathermy was practically only used in Sweden. Infiltration with epinephrine in the tonsillar bed was registered in Sweden and Norway but not at all in Denmark. Combined cold surgical and cold haemostatic techniques were more commonly used in Sweden (22.7%) than in Norway (10.4%) and Denmark (6.2%). Conclusions This study demonstrates disparities among the Nordic countries in tonsil surgery in terms of indications plus surgical and haemostatic techniques. Increased coverage, Funding Agencies|Nordic council

Published
2022
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39. Development and Psychometric Validation of the Taste And Smell Tool for Evaluation (TASTE) Questionnaire

Author

Niklassen, Andreas Steenholt, Christensen, Karl Bang, Fjaeldstad, Alexander Wieck, Ovesen, Therese, Niklassen, Andreas Steenholt, Christensen, Karl Bang, Fjaeldstad, Alexander Wieck, and Ovesen, Therese

Abstract

Can a thorough questionnaire be developed comprising all relevant domains concerning chemosensory dysfunction using modern psychometric methods and perform well?, IMPORTANCE The human senses of taste and smell are essential in everyday life. However, as clinical testing of the senses and patient-reported sensory problems are often diverging, additional validated questionnaires are essential for the evaluation of chemosensory impairments.OBJECTIVE To develop an instrument with all relevant domains concerning chemosensory dysfunction and quality of life using modern psychometrics.DESIGN, SETTING, AND PARTICIPANTS The study was designed as a questionnaire study for developing a new instrument. The study started in 2019 and was completed in 2022. Patients with chemosensory dysfunction were recruited from a specialized smell and taste clinic at an ear, nose, and throat department in Denmark. Healthy participants with no history of chemosensory dysfunction were recruited through social media.MAIN OUTCOMES AND MEASURES Eight domains were included (distorted chemosensation, emotional, food and meals, social, hygiene, danger, work, and relationship), and 35 items were generated based on review of the existing literature and interviews with patients and experts. Participants were tested with the Major Depression Inventory, 36-Item Short Form Health Survey, Taste Sprays, and Sniffin' Sticks for chemosensory function. Descriptive statistics were calculated for all items. Reliability, internal consistency, and validity were investigated, and a Rasch model was fitted. Healthy controls (n = 39) filled out the questionnaire for comparison of known-groups validity. Confirmatory factor analysis was performed. Finally, item reduction was performed, resulting in a final version with 21 items in 8 domains.RESULTS The study included responses from 316 patients, 183 women (58%) and 133 men (42%), with a mean (SD) age of 57 (15.1) years. Rasch model fit was acceptable with P > .05 for all items. An 8-dimensional confirmatory factor analysis model showed a better fit than a bifactor confirmatory factor analysis model

Published
2022

44. Spændende alternativ til CT

Author

Holm, Niels Højvang, Mikkelsen, Anders Frodo Stegmann, Ovesen, Therese, and Pedersen, Michael

Published
2022

45. Næsen kan være fokus for behandling af og profylakse mod COVID-19

Author

Rusan, Maria, Ovesen, Thomas Oliver Kamarauskas, Fuursted, Kurt, and Ovesen, Therese

Subjects
biochemical phenomena, metabolism, and nutrition
Abstract

Infection with SARS-CoV-2 frequently commences in the nasal cavity, yet knowledge about this initial virus-host interaction is sparse. In this review, we update our current understanding of SARS-CoV-2 infection via the nasal epithelium and the associated local immune response. Furthermore, we present considerations to how this interaction may influence the clinical course of COVID-19 and the systemic immune response, and lastly touch upon the potential for intranasal vaccination, intranasal antiviral therapies and immunomodulatory approaches.

Published
2022

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