Search

Your search keyword '"Overgaard, Line E. K."' showing total 7 results
Start Over Author "Overgaard, Line E. K."
7 results on '"Overgaard, Line E. K."'

3. Contact allergy to lanolin:temporal changes in prevalence and association with atopic dermatitis

Author

Fransen, Marloes, Overgaard, Line E K, Johansen, Jeanne D, Thyssen, Jacob P, Fransen, Marloes, Overgaard, Line E K, Johansen, Jeanne D, and Thyssen, Jacob P

Abstract

BACKGROUND: Lanolin has been tested as lanolin alcohols (30% pet.) in baseline patch test series since 1969, and this has shown clinically relevant allergic contact dermatitis cases.OBJECTIVES: To investigate the temporal development of lanolin allergy (i.e. positive reaction to lanolin alcohols and/or Amerchol™ L-101), and the association between contact allergy to lanolin and patient characteristics from the MOAHLFA index.METHODS: A retrospective observational study of consecutively patch tested dermatitis patients (n = 9577) between 1 January 2004 and 31 December 2015 with lanolin alcohols 30% pet. and Amerchol™ L-101 50% pet. was performed.RESULTS: The prevalence of lanolin allergy increased from 0.45% in 2004 to 1.81% in 2015. In age-adjusted and sex-adjusted analyses, weak, significant associations were found between atopic dermatitis and lanolin and lanolin alcohols allergy, respectively, but no association with Amerchol™ L-101 allergy was found. Among 9286 dermatitis patients who were tested with both allergens, 108 had a positive test reaction to either lanolin alcohols or Amerchol™ L-101, whereas only 29 patients had positive test reactions to both markers.CONCLUSIONS: The prevalence of lanolin contact allergy has increased over a 12-year period, and inclusion of Amerchol™ L-101 will increase the chance of detecting lanolin contact allergy. Patch testing with lanolin is helpful in atopics with dermatitis and suspected cosmetic allergy.

Published
2018

7. The association between phthalate exposure and atopic dermatitis with a discussion of phthalate induced secretion of interleukin-1β and thymic stromal lymphopoietin.

Author

Overgaard LE, Bonefeld CM, Frederiksen H, Main KM, and Thyssen JP

Subjects
Animals, Dermatitis, Atopic chemically induced, Dermatitis, Atopic genetics, Environmental Exposure adverse effects, Filaggrin Proteins, Humans, Interleukin-4 genetics, Interleukin-4 metabolism, Intermediate Filament Proteins genetics, Mutation genetics, Phthalic Acids adverse effects, Thymic Stromal Lymphopoietin, Cytokines metabolism, Dermatitis, Atopic immunology, Interleukin-1beta metabolism, Phthalic Acids metabolism
Abstract

Phthalate diesters are widely used as emollients in plastic and cosmetics as well as in food packaging and perfumes, potentially leading to prolonged and repeated dermal, oral and airborne exposure. We here review published articles that have evaluated the putative role of phthalate diesters in the pathogenesis of atopic dermatitis and discuss possible pathogenic pathways. A literature search resulted in 563 articles in Embase and 263 articles in Pubmed. After identification of relevant articles based on screening of titles, abstracts and reference lists, a total of 39 articles were selected and included. While no clear association has been shown between systemic phthalate levels and atopic dermatitis in human studies, animal data suggests that phthalates may worsen dermatitis and in vitro data suggests that interleukin-4 could be upregulated. Moreover, both loss-of-function mutations in the filaggrin gene and atopic dermatitis have been associated with elevated systemic phthalate levels. There is a need for prospective studies to clarify the possible pathogenic role of phthalate diesters in atopic dermatitis and the associated health risk, especially with the general trend towards barrier restoration with emollients in infants at risk of developing atopic dermatitis. In summary, we conclude that the results from published studies are controversial and inconclusive.

Published
2016
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results