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2. Moonlighting matrix metalloproteinase substrates: Enhancement of proinflammatory functions of extracellular tyrosyl-tRNA synthetase upon cleavage

Author

Jobin, Parker G, Solis, Nestor, Machado, Yoan, Bell, Peter A, Rai, Simran K, Kwon, Nam Hoon, Kim, Sunghoon, Overall, Christopher M, and Butler, Georgina S

Subjects
Biochemistry and Cell Biology, Biomedical and Clinical Sciences, Biological Sciences, Chemokines, Chemotaxis, Enzyme Stability, Extracellular Space, Humans, Inflammation Mediators, Macrophages, Matrix Metalloproteinases, Models, Biological, Monocytes, NF-kappa B, Signal Transduction, Substrate Specificity, THP-1 Cells, Toll-Like Receptor 2, Tumor Necrosis Factor-alpha, Tyrosine, Tyrosine-tRNA Ligase, aminoacyl tRNA synthetase, inflammation, innate immunity, macrophage, matrix metalloproteinase, moonlighting proteins, multifunctional protein, proteolysis, toll-like receptor, Chemical Sciences, Medical and Health Sciences, Biochemistry & Molecular Biology, Biological sciences, Biomedical and clinical sciences, Chemical sciences
Abstract

Tyrosyl-tRNA synthetase ligates tyrosine to its cognate tRNA in the cytoplasm, but it can also be secreted through a noncanonical pathway. We found that extracellular tyrosyl-tRNA synthetase (YRS) exhibited proinflammatory activities. In addition to acting as a monocyte/macrophage chemoattractant, YRS initiated signaling through Toll-like receptor 2 (TLR2) resulting in NF-κB activation and release of tumor necrosis factor α (TNFα) and multiple chemokines, including MIP-1α/β, CXCL8 (IL8), and CXCL1 (KC) from THP1 monocyte and peripheral blood mononuclear cell-derived macrophages. Furthermore, YRS up-regulated matrix metalloproteinase (MMP) activity in a TNFα-dependent manner in M0 macrophages. Because MMPs process a variety of intracellular proteins that also exhibit extracellular moonlighting functions, we profiled 10 MMPs for YRS cleavage and identified 55 cleavage sites by amino-terminal oriented mass spectrometry of substrates (ATOMS) positional proteomics and Edman degradation. Stable proteoforms resulted from cleavages near the start of the YRS C-terminal EMAPII domain. All of the MMPs tested cleaved at ADS386↓387LYV and VSG405↓406LVQ, generating 43- and 45-kDa fragments. The highest catalytic efficiency for YRS was demonstrated by MMP7, which is highly expressed by monocytes and macrophages, and by neutrophil-specific MMP8. MMP-cleaved YRS enhanced TLR2 signaling, increased TNFα secretion from macrophages, and amplified monocyte/macrophage chemotaxis compared with unprocessed YRS. The cleavage of YRS by MMP8, but not MMP7, was inhibited by tyrosine, a substrate of the YRS aminoacylation reaction. Overall, the proinflammatory activity of YRS is enhanced by MMP cleavage, which we suggest forms a feed-forward mechanism to promote inflammation.

Published
2020

3. Matrix metalloproteinases inactivate the proinflammatory functions of secreted moonlighting tryptophanyl-tRNA synthetase

Author

Jobin, Parker G, Solis, Nestor, Machado, Yoan, Bell, Peter A, Kwon, Nam Hoon, Kim, Sunghoon, Overall, Christopher M, and Butler, Georgina S

Subjects
Biochemistry and Cell Biology, Biomedical and Clinical Sciences, Biological Sciences, Cells, Cultured, Endothelial Cells, Fibroblasts, Humans, Inflammation, Interferon-gamma, Macrophages, Matrix Metalloproteinases, Tryptophan-tRNA Ligase, multifunctional protein, aminoacyl tRNA synthetase, proteolysis, matrix metalloproteinase, interferon, inflammation, toll-like receptor, monocyte, macrophage, innate immunity, Chemical Sciences, Medical and Health Sciences, Biochemistry & Molecular Biology, Biological sciences, Biomedical and clinical sciences, Chemical sciences
Abstract

Tryptophanyl-tRNA synthetase (WRS) is a cytosolic aminoacyl-tRNA synthetase essential for protein synthesis. WRS is also one of a growing number of intracellular proteins that are attributed distinct noncanonical "moonlighting" functions in the extracellular milieu. Moonlighting aminoacyl-tRNA synthetases regulate processes such as inflammation, but how these multifunctional enzymes are themselves regulated remains unclear. Here, we demonstrate that WRS is secreted from human macrophages, fibroblasts, and endothelial cells in response to the proinflammatory cytokine interferon γ (IFNγ). WRS signaled primarily through Toll-like receptor 2 (TLR2) in macrophages, leading to phosphorylation of the p65 subunit of NF-κB with associated loss of NF-κB inhibitor α (IκB-α) protein. This signaling initiated secretion of tumor necrosis factor α (TNFα) and CXCL8 (IL8) from macrophages. We also demonstrated that WRS is a potent monocyte chemoattractant. Of note, WRS increased matrix metalloproteinase (MMP) activity in the conditioned medium of macrophages in a TNFα-dependent manner. Using purified recombinant proteins and LC-MS/MS to identify proteolytic cleavage sites, we demonstrated that multiple MMPs, but primarily macrophage MMP7 and neutrophil MMP8, cleave secreted WRS at several sites. Loss of the WHEP domain following cleavage at Met48 generated a WRS proteoform that also results from alternative splicing, designated Δ1-47 WRS. The MMP-cleaved WRS lacked TLR signaling and proinflammatory activities. Thus, our results suggest that moonlighting WRS promotes IFNγ proinflammatory activities, and these responses can be dampened by MMPs.

Published
2019

5. Optimization of quenched fluorescent peptide substrates of SARS-CoV-2 3CL pro main protease (Mpro) from proteomic identification of P6—P6' active site specificity

Author

Cesar Ramos de Jesus, Hugo, primary, Solis, Nestor, additional, Machado, Yoan, additional, Pablos, Isabel, additional, Bell, Peter A., additional, Kappelhoff, Reinhild, additional, Grin, Peter M., additional, Sorgi, Carlos A., additional, Butler, Georgina S., additional, and Overall, Christopher M., additional

Published
2024
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7. The 2023 Report on the Proteome from the HUPO Human Proteome Project

Author

Omenn, Gilbert S., Lane, Lydie, Overall, Christopher M., Lindskog, Cecilia, Pineau, Charles, Packer, Nicolle H., Cristea, Ileana M., Weintraub, Susan T., Orchard, Sandra, Roehrl, Michael H. A., Nice, Edouard, Guo, Tiannan, Van Eyk, Jennifer E., Liu, Siqi, Bandeira, Nuno, Aebersold, Ruedi, Moritz, Robert L., Deutsch, Eric W., Omenn, Gilbert S., Lane, Lydie, Overall, Christopher M., Lindskog, Cecilia, Pineau, Charles, Packer, Nicolle H., Cristea, Ileana M., Weintraub, Susan T., Orchard, Sandra, Roehrl, Michael H. A., Nice, Edouard, Guo, Tiannan, Van Eyk, Jennifer E., Liu, Siqi, Bandeira, Nuno, Aebersold, Ruedi, Moritz, Robert L., and Deutsch, Eric W.

Abstract

Since 2010, the Human Proteome Project (HPP), the flagship initiative of the Human Proteome Organization (HUPO), has pursued two goals: (1) to credibly identify the protein parts list and (2) to make proteomics an integral part of multiomics studies of human health and disease. The HPP relies on international collaboration, data sharing, standardized reanalysis of MS data sets by PeptideAtlas and MassIVE-KB using HPP Guidelines for quality assurance, integration and curation of MS and non-MS protein data by neXtProt, plus extensive use of antibody profiling carried out by the Human Protein Atlas. According to the neXtProt release 2023-04-18, protein expression has now been credibly detected (PE1) for 18,397 of the 19,778 neXtProt predicted proteins coded in the human genome (93%). Of these PE1 proteins, 17,453 were detected with mass spectrometry (MS) in accordance with HPP Guidelines and 944 by a variety of non-MS methods. The number of neXtProt PE2, PE3, and PE4 missing proteins now stands at 1381. Achieving the unambiguous identification of 93% of predicted proteins encoded from across all chromosomes represents remarkable experimental progress on the Human Proteome parts list. Meanwhile, there are several categories of predicted proteins that have proved resistant to detection regardless of protein-based methods used. Additionally there are some PE1–4 proteins that probably should be reclassified to PE5, specifically 21 LINC entries and ∼30 HERV entries; these are being addressed in the present year. Applying proteomics in a wide array of biological and clinical studies ensures integration with other omics platforms as reported by the Biology and Disease-driven HPP teams and the antibody and pathology resource pillars. Current progress has positioned the HPP to transition to its Grand Challenge Project focused on determining the primary function(s) of every protein itself and in networks and pathways within the context of human health and disease.

Published
2024
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8. The 2023 Report on the Proteome from the HUPO Human Proteome Project

Author

Omenn, Gilbert S., primary, Lane, Lydie, additional, Overall, Christopher M., additional, Lindskog, Cecilia, additional, Pineau, Charles, additional, Packer, Nicolle H., additional, Cristea, Ileana M., additional, Weintraub, Susan T., additional, Orchard, Sandra, additional, Roehrl, Michael H. A., additional, Nice, Edouard, additional, Guo, Tiannan, additional, Van Eyk, Jennifer E., additional, Liu, Siqi, additional, Bandeira, Nuno, additional, Aebersold, Ruedi, additional, Moritz, Robert L., additional, and Deutsch, Eric W., additional

Published
2024
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10. Hydrolases & Lipases in GtoPdb v.2023.3

Author

Alexander, Stephen P.H., primary, Doherty, Patrick, primary, Fairlie, David, primary, Fowler, Christopher J., primary, Overall, Christopher M., primary, Rawlings, Neil, primary, Southan, Christopher, primary, and Turner, Anthony J., primary

Published
2023
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12. An allosteric MALT1 inhibitor is a molecular corrector rescuing function in an immunodeficient patient

Author

Quancard, Jean, Klein, Theo, Fung, Shan-Yu, Renatus, Martin, Hughes, Nicola, Israël, Laura, Priatel, John J., Kang, Sohyeong, Blank, Michael A., Viner, Rosa I., Blank, Jutta, Schlapbach, Achim, Erbel, Paul, Kizhakkedathu, Jayachandran, Villard, Frédéric, Hersperger, René, Turvey, Stuart E., Eder, Joerg, Bornancin, Frédéric, and Overall, Christopher M.

Published
2019
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14. Ulrich auf dem Keller (1974–2023)

Author

Ågren, Magnus S., primary, Hinz, Boris, additional, Kalogeropoulos, Konstantinos, additional, Overall, Christopher M., additional, Smola, Hans, additional, and Werner, Sabine, additional

Published
2023
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17. A high-stringency blueprint of the human proteome

Author

Adhikari, Subash, Nice, Edouard C., Deutsch, Eric W., Lane, Lydie, Omenn, Gilbert S., Pennington, Stephen R., Paik, Young-Ki, Overall, Christopher M., Corrales, Fernando J., Cristea, Ileana M., Van Eyk, Jennifer E., Uhlén, Mathias, Lindskog, Cecilia, Chan, Daniel W., Bairoch, Amos, Waddington, James C., Justice, Joshua L., LaBaer, Joshua, Rodriguez, Henry, He, Fuchu, Kostrzewa, Markus, Ping, Peipei, Gundry, Rebekah L., Stewart, Peter, Srivastava, Sanjeeva, Srivastava, Sudhir, Nogueira, Fabio C. S., Domont, Gilberto B., Vandenbrouck, Yves, Lam, Maggie P. Y., Wennersten, Sara, Vizcaino, Juan Antonio, Wilkins, Marc, Schwenk, Jochen M., Lundberg, Emma, Bandeira, Nuno, Marko-Varga, Gyorgy, Weintraub, Susan T., Pineau, Charles, Kusebauch, Ulrike, Moritz, Robert L., Ahn, Seong Beom, Palmblad, Magnus, Snyder, Michael P., Aebersold, Ruedi, and Baker, Mark S.

Published
2020
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21. Hydrolases in GtoPdb v.2023.1

Author

Alexander, Stephen P.H., primary, Doherty, Patrick, primary, Fairlie, David, primary, Fowler, Christopher J., primary, Overall, Christopher M., primary, Rawlings, Neil, primary, Southan, Christopher, primary, and Turner, Anthony J., primary

Published
2023
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22. The 2022 Report on the Human Proteome from the HUPO Human Proteome Project

Author

Omenn, Gilbert S., Lane, Lydie, Overall, Christopher M., Pineau, Charles, Packer, Nicolle H., Cristea, Ileana M., Lindskog, Cecilia, Weintraub, Susan T., Orchard, Sandra, Roehrl, Michael H. A., Nice, Edouard, Liu, Siqi, Bandeira, Nuno, Chen, Yu-Ju, Guo, Tiannan, Aebersold, Ruedi, Moritz, Robert L., Deutsch, Eric W., Omenn, Gilbert S., Lane, Lydie, Overall, Christopher M., Pineau, Charles, Packer, Nicolle H., Cristea, Ileana M., Lindskog, Cecilia, Weintraub, Susan T., Orchard, Sandra, Roehrl, Michael H. A., Nice, Edouard, Liu, Siqi, Bandeira, Nuno, Chen, Yu-Ju, Guo, Tiannan, Aebersold, Ruedi, Moritz, Robert L., and Deutsch, Eric W.

Abstract

The 2022 Metrics of the Human Proteome from the HUPO Human Proteome Project (HPP) show that protein expression has now been credibly detected (neXtProt PE1 level) for 18 407 (93.2%) of the 19 750 predicted proteins coded in the human genome, a net gain of 50 since 2021 from data sets generated around the world and reanalyzed by the HPP. Conversely, the number of neXtProt PE2, PE3, and PE4 missing proteins has been reduced by 78 from 1421 to 1343. This represents continuing experimental progress on the human proteome parts list across all the chromosomes, as well as significant reclassifications. Meanwhile, applying proteomics in a vast array of biological and clinical studies continues to yield significant findings and growing integration with other omics platforms. We present highlights from the Chromosome-Centric HPP, Biology and Disease-driven HPP, and HPP Resource Pillars, compare features of mass spectrometry and Olink and Somalogic platforms, note the emergence of translation products from ribosome profiling of small open reading frames, and discuss the launch of the initial HPP Grand Challenge Project, “A Function for Each Protein”.

Published
2023
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26. Supplementary Methods, Tables 1-3 from Dissecting the Role of Matrix Metalloproteinases (MMP) and Integrin αvβ3 in Angiogenesis In vitro: Absence of Hemopexin C Domain Bioactivity, but Membrane-Type 1-MMP and αvβ3 Are Critical

Author

Nisato, Riccardo E., primary, Hosseini, Ghamartaj, primary, Sirrenberg, Christian, primary, Butler, Georgina S., primary, Crabbe, Thomas, primary, Docherty, Andrew J.P., primary, Wiesner, Matthias, primary, Murphy, Gillian, primary, Overall, Christopher M., primary, Goodman, Simon L., primary, and Pepper, Michael S., primary

Published
2023
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27. Supplementary Figure 3 from Targeting Tumor Hypoxia: Suppression of Breast Tumor Growth and Metastasis by Novel Carbonic Anhydrase IX Inhibitors

Author

Lou, Yuanmei, primary, McDonald, Paul C., primary, Oloumi, Arusha, primary, Chia, Stephen, primary, Ostlund, Christina, primary, Ahmadi, Ardalan, primary, Kyle, Alastair, primary, auf dem Keller, Ulrich, primary, Leung, Samuel, primary, Huntsman, David, primary, Clarke, Blaise, primary, Sutherland, Brent W., primary, Waterhouse, Dawn, primary, Bally, Marcel, primary, Roskelley, Calvin, primary, Overall, Christopher M., primary, Minchinton, Andrew, primary, Pacchiano, Fabio, primary, Carta, Fabrizio, primary, Scozzafava, Andrea, primary, Touisni, Nadia, primary, Winum, Jean-Yves, primary, Supuran, Claudiu T., primary, and Dedhar, Shoukat, primary

Published
2023
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28. Supplementary Tables 1-4 from Targeting Tumor Hypoxia: Suppression of Breast Tumor Growth and Metastasis by Novel Carbonic Anhydrase IX Inhibitors

Author

Lou, Yuanmei, primary, McDonald, Paul C., primary, Oloumi, Arusha, primary, Chia, Stephen, primary, Ostlund, Christina, primary, Ahmadi, Ardalan, primary, Kyle, Alastair, primary, auf dem Keller, Ulrich, primary, Leung, Samuel, primary, Huntsman, David, primary, Clarke, Blaise, primary, Sutherland, Brent W., primary, Waterhouse, Dawn, primary, Bally, Marcel, primary, Roskelley, Calvin, primary, Overall, Christopher M., primary, Minchinton, Andrew, primary, Pacchiano, Fabio, primary, Carta, Fabrizio, primary, Scozzafava, Andrea, primary, Touisni, Nadia, primary, Winum, Jean-Yves, primary, Supuran, Claudiu T., primary, and Dedhar, Shoukat, primary

Published
2023
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29. Data from Targeting Tumor Hypoxia: Suppression of Breast Tumor Growth and Metastasis by Novel Carbonic Anhydrase IX Inhibitors

Author

Lou, Yuanmei, primary, McDonald, Paul C., primary, Oloumi, Arusha, primary, Chia, Stephen, primary, Ostlund, Christina, primary, Ahmadi, Ardalan, primary, Kyle, Alastair, primary, auf dem Keller, Ulrich, primary, Leung, Samuel, primary, Huntsman, David, primary, Clarke, Blaise, primary, Sutherland, Brent W., primary, Waterhouse, Dawn, primary, Bally, Marcel, primary, Roskelley, Calvin, primary, Overall, Christopher M., primary, Minchinton, Andrew, primary, Pacchiano, Fabio, primary, Carta, Fabrizio, primary, Scozzafava, Andrea, primary, Touisni, Nadia, primary, Winum, Jean-Yves, primary, Supuran, Claudiu T., primary, and Dedhar, Shoukat, primary

Published
2023
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30. Supplementary Figures 1-2, Methods from Novel Matrix Metalloproteinase Inhibitor [18F]Marimastat-Aryltrifluoroborate as a Probe for In vivo Positron Emission Tomography Imaging in Cancer

Author

auf dem Keller, Ulrich, primary, Bellac, Caroline L., primary, Li, Ying, primary, Lou, Yuanmei, primary, Lange, Philipp F., primary, Ting, Richard, primary, Harwig, Curtis, primary, Kappelhoff, Reinhild, primary, Dedhar, Shoukat, primary, Adam, Michael J., primary, Ruth, Thomas J., primary, Bénard, François, primary, Perrin, David M., primary, and Overall, Christopher M., primary

Published
2023
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31. Supplementary Figure 1 from Targeting Tumor Hypoxia: Suppression of Breast Tumor Growth and Metastasis by Novel Carbonic Anhydrase IX Inhibitors

Author

Lou, Yuanmei, primary, McDonald, Paul C., primary, Oloumi, Arusha, primary, Chia, Stephen, primary, Ostlund, Christina, primary, Ahmadi, Ardalan, primary, Kyle, Alastair, primary, auf dem Keller, Ulrich, primary, Leung, Samuel, primary, Huntsman, David, primary, Clarke, Blaise, primary, Sutherland, Brent W., primary, Waterhouse, Dawn, primary, Bally, Marcel, primary, Roskelley, Calvin, primary, Overall, Christopher M., primary, Minchinton, Andrew, primary, Pacchiano, Fabio, primary, Carta, Fabrizio, primary, Scozzafava, Andrea, primary, Touisni, Nadia, primary, Winum, Jean-Yves, primary, Supuran, Claudiu T., primary, and Dedhar, Shoukat, primary

Published
2023
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32. Supplementary Figure 2 from Targeting Tumor Hypoxia: Suppression of Breast Tumor Growth and Metastasis by Novel Carbonic Anhydrase IX Inhibitors

Author

Lou, Yuanmei, primary, McDonald, Paul C., primary, Oloumi, Arusha, primary, Chia, Stephen, primary, Ostlund, Christina, primary, Ahmadi, Ardalan, primary, Kyle, Alastair, primary, auf dem Keller, Ulrich, primary, Leung, Samuel, primary, Huntsman, David, primary, Clarke, Blaise, primary, Sutherland, Brent W., primary, Waterhouse, Dawn, primary, Bally, Marcel, primary, Roskelley, Calvin, primary, Overall, Christopher M., primary, Minchinton, Andrew, primary, Pacchiano, Fabio, primary, Carta, Fabrizio, primary, Scozzafava, Andrea, primary, Touisni, Nadia, primary, Winum, Jean-Yves, primary, Supuran, Claudiu T., primary, and Dedhar, Shoukat, primary

Published
2023
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33. Supplementary Methods, Legends for Figures 1-5 from Targeting Tumor Hypoxia: Suppression of Breast Tumor Growth and Metastasis by Novel Carbonic Anhydrase IX Inhibitors

Author

Lou, Yuanmei, primary, McDonald, Paul C., primary, Oloumi, Arusha, primary, Chia, Stephen, primary, Ostlund, Christina, primary, Ahmadi, Ardalan, primary, Kyle, Alastair, primary, auf dem Keller, Ulrich, primary, Leung, Samuel, primary, Huntsman, David, primary, Clarke, Blaise, primary, Sutherland, Brent W., primary, Waterhouse, Dawn, primary, Bally, Marcel, primary, Roskelley, Calvin, primary, Overall, Christopher M., primary, Minchinton, Andrew, primary, Pacchiano, Fabio, primary, Carta, Fabrizio, primary, Scozzafava, Andrea, primary, Touisni, Nadia, primary, Winum, Jean-Yves, primary, Supuran, Claudiu T., primary, and Dedhar, Shoukat, primary

Published
2023
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34. Data from Novel Matrix Metalloproteinase Inhibitor [18F]Marimastat-Aryltrifluoroborate as a Probe for In vivo Positron Emission Tomography Imaging in Cancer

Author

auf dem Keller, Ulrich, primary, Bellac, Caroline L., primary, Li, Ying, primary, Lou, Yuanmei, primary, Lange, Philipp F., primary, Ting, Richard, primary, Harwig, Curtis, primary, Kappelhoff, Reinhild, primary, Dedhar, Shoukat, primary, Adam, Michael J., primary, Ruth, Thomas J., primary, Bénard, François, primary, Perrin, David M., primary, and Overall, Christopher M., primary

Published
2023
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35. Supplementary Figure 5 from Targeting Tumor Hypoxia: Suppression of Breast Tumor Growth and Metastasis by Novel Carbonic Anhydrase IX Inhibitors

Author

Lou, Yuanmei, primary, McDonald, Paul C., primary, Oloumi, Arusha, primary, Chia, Stephen, primary, Ostlund, Christina, primary, Ahmadi, Ardalan, primary, Kyle, Alastair, primary, auf dem Keller, Ulrich, primary, Leung, Samuel, primary, Huntsman, David, primary, Clarke, Blaise, primary, Sutherland, Brent W., primary, Waterhouse, Dawn, primary, Bally, Marcel, primary, Roskelley, Calvin, primary, Overall, Christopher M., primary, Minchinton, Andrew, primary, Pacchiano, Fabio, primary, Carta, Fabrizio, primary, Scozzafava, Andrea, primary, Touisni, Nadia, primary, Winum, Jean-Yves, primary, Supuran, Claudiu T., primary, and Dedhar, Shoukat, primary

Published
2023
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36. Supplementary Figure 4 from Targeting Tumor Hypoxia: Suppression of Breast Tumor Growth and Metastasis by Novel Carbonic Anhydrase IX Inhibitors

Author

Lou, Yuanmei, primary, McDonald, Paul C., primary, Oloumi, Arusha, primary, Chia, Stephen, primary, Ostlund, Christina, primary, Ahmadi, Ardalan, primary, Kyle, Alastair, primary, auf dem Keller, Ulrich, primary, Leung, Samuel, primary, Huntsman, David, primary, Clarke, Blaise, primary, Sutherland, Brent W., primary, Waterhouse, Dawn, primary, Bally, Marcel, primary, Roskelley, Calvin, primary, Overall, Christopher M., primary, Minchinton, Andrew, primary, Pacchiano, Fabio, primary, Carta, Fabrizio, primary, Scozzafava, Andrea, primary, Touisni, Nadia, primary, Winum, Jean-Yves, primary, Supuran, Claudiu T., primary, and Dedhar, Shoukat, primary

Published
2023
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40. Want to Publish in JPR? This Is What You Need to Know!

Author

Yates, John R., primary, Cristea, Ileana M., additional, Dong, Meng-Qui, additional, Eyers, Claire E., additional, LaBaer, Joshua, additional, Li, Jia V., additional, Nicholson, Jeremy K., additional, Overall, Christopher M., additional, Palmblad, Magnus, additional, and Slavov, Nikolai, additional

Published
2022
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41. The 2022 Report on the Human Proteome from the HUPO Human Proteome Project

Author

Omenn, Gilbert S., primary, Lane, Lydie, additional, Overall, Christopher M., additional, Pineau, Charles, additional, Packer, Nicolle H., additional, Cristea, Ileana M., additional, Lindskog, Cecilia, additional, Weintraub, Susan T., additional, Orchard, Sandra, additional, Roehrl, Michael H. A., additional, Nice, Edouard, additional, Liu, Siqi, additional, Bandeira, Nuno, additional, Chen, Yu-Ju, additional, Guo, Tiannan, additional, Aebersold, Ruedi, additional, Moritz, Robert L., additional, and Deutsch, Eric W., additional

Published
2022
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