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As the fallopian tubes come to the fore as the source of the most common form of ovarian cancer, researchers and clinicians are devising strategies to prevent the disease. As the fallopian tubes come to the fore as the source of the most common form of ovarian cancer, researchers and clinicians are devising strategies to prevent the disease., Author(s): Sarah DeWeerdt Author Affiliations: The origins of ovarian cancer Risk-reducing surgery to remove the fallopian tubes and ovaries is performed on people with ovarian cancer risk genes, such as [...]

Vaginal microbes influence the health of the reproductive system, but do they play a part in ovarian tumours? Vaginal microbes influence the health of the reproductive system, but do they play a part in ovarian tumours?, Author(s): Julianna Photopoulos Author Affiliations: Ovarian cancer and the microbiome: a complex relationship Martin Widschwendter studies the links between the vaginal microbiota and ovarian cancer. Credit: Martin Widschwendter Martin Widschwendter [...]

Risks of breast and ovarian cancer were determined for Ashkenazi Jewish women with inherited mutations in the tumor suppressor genes BRCA1 and BRCA2. We selected 1008 index cases, regardless of family history of cancer, and carried out molecular analysis across entire families. The lifetime risk of breast cancer among female mutation carriers was 82%, similar to risks in families with many cases. Risks appear to be increasing with time: Breast cancer risk by age 50 among mutation carriers born before 1940 was 24%, but among those born after 1940 it was 67%. Lifetime risks of ovarian cancer were 54% for BRCA1 and 23% for BRCA2 mutation carriers. Physical exercise and lack of obesity in adolescence were associated with significantly delayed breast cancer onset., Breast cancer is the most common malignancy among women, with a lifetime risk of more than 10%. Ovarian cancer is rarer, with a lifetime risk of 1.8%, but it is [...]

Penetrances of BRCA1 and BRCA2 mutations have been derived from retrospective studies, implying the possibility of ascertainment biases to influence the results. We have followed women at risk for breast and/or ovarian cancer for two decades, and report the prospectively observed age-related annual incidence rates to contract breast or ovarian cancer for women with deleterious BRCA1 or BRCA2 mutations based on 4830 observation years. Patients were grouped according to mutation, age and having/not having had previous cancer. In women not having had previous cancer and aged 40-59 years, the annual incidence rate to contract breast or ovarian cancer in those having the most frequent BRCA1 founder mutations was 4.0%, for women in this age group and with less frequent BRCA1 mutations annual incidence rate was 5.9%, and for women with BRCA2 mutations 3.5%. The observed figures may be used for genetic counseling of healthy mutation carriers in the respective age groups. The results may indicate that less frequent BRCA1 mutations have higher penetrances than BRCA1 founder mutations., Authors: Pål Møller (corresponding author) [1]; Lovise Maehle [1]; Lars F Engebretsen [2]; Trond Ludvigsen [3]; Christoffer Jonsrud [4]; Jaran Apold [2]; Anita Vabø [1]; Neal Clark [1] Introduction Mutations [...]