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203 results on '"Ouyang, Yi‐Bing"'

14. Phosphorylation of Extracellular Signal-Regulated Kinase after Transient Cerebral Ischemia in Hyperglycemic Rats

Author

Ping-An Li, Qing Ping He, Ouyang Yi-Bing, Bing Ren Hu, and Bo K. Siesjö

Subjects
hyperglycemia, cerebral ischemia, ERK, MAP kinase, immunocytochemistry, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571
Abstract

The present study was undertaken to investigate whether extracellular signal-regulated kinase (ERK) was involved in mediating hyperglycemia-exaggerated cerebral ischemic damage. Phosphorylation of ERK 1/2 was studied by immunocytochemistry and by Western blot analyses. Rats were subjected to 15 min of forebrain ischemia, followed by 0.5, 1, and 3 h of reperfusion under normoglycemic and hyperglycemic conditions. The results showed that in normoglycemic animals, moderate phosphorylation of ERK 1/2 was transiently induced after 0.5 h of recovery in cingulate cortex and in dentate gyrus, returning to control values thereafter. In hyperglycemic animals, phosphorylation of ERK 1/2 was markedly increased in the cingulate cortex and dentate gyrus after 0.5 h of recovery, the increases being sustained for at least 3 h after reperfusion. Hyperglycemia also induced phosphorylation of ERK 1/2 in the hippocampal CA3 sector but not in the CA1 area. Thus, the distribution of phospho-ERK 1/2 coincides with hyperglycemia-recruited damage structures. The results suggest that hyperglycemia may influence the outcome of an ischemic insult by modulating signal transduction pathways involving ERK 1/2.

Published
2001
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42. Mini-review: Neuroprotection by astrocytes in brain ischemia: importance of microRNAs

Author

Ouyang, Yi-Bing, Xu, Lijun, Yue, Sibiao, Liu, Siwei, and Giffard, Rona G.

Subjects
Neurons, MicroRNAs, Cell Survival, Astrocytes, Animals, Humans, Genetic Therapy, Article, Brain Ischemia
Abstract

Astrocytes have been shown to protect neurons and increase their survival in many pathological settings. Manipulating astrocyte functions is thus an important strategy to enhance neuronal survival and improve outcome following cerebral ischemia. Increasing evidence supports the involvement of microRNAs (miRNA), some of them being astrocyte-enriched, in the regulation of cerebral ischemia. This mini review will focus on several recently reported astrocyte-enriched miRNAs (miR-181 and miR-29 families and miR-146a), their validated targets, regional expression and effects on outcome after cerebral ischemia.

Published
2013

44. ER-Mitochondria Crosstalk during Cerebral Ischemia: Molecular Chaperones and ER-Mitochondrial Calcium Transfer

Author

Ouyang, Yi-Bing and Giffard, Rona G.

Subjects
Article Subject
Abstract

It is commonly believed that sustained elevations in the mitochondrial matrix Ca2+ concentration are a major feature of the intracellular cascade of lethal events during cerebral ischemia. The physical association between the endoplasmic reticulum (ER) and mitochondria, known as the mitochondria-associated ER membrane (MAM), enables highly efficient transmission of Ca2+ from the ER to mitochondria under both physiological and pathological conditions. Molecular chaperones are well known for their protective effects during cerebral ischemia. It has been demonstrated recently that many molecular chaperones coexist with MAM and regulate the MAM and thus Ca2+ concentration inside mitochondria. Here, we review recent research on cerebral ischemia and MAM, with a focus on molecular chaperones and ER-mitochondrial calcium transfer.

Published
2012
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