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4. Evaluating the usability of open source frameworks in energy system modelling

Author

Berendes, S., Hilpert, S., Günther, S., Muschner, C., Candas, S., Hainsch, K., van Ouwerkerk, J., Buchholz, S., Söthe, M., Berendes, S., Hilpert, S., Günther, S., Muschner, C., Candas, S., Hainsch, K., van Ouwerkerk, J., Buchholz, S., and Söthe, M.

Abstract

Usability is considered one of the key factors in determining the success of Open Source Software, but is it sufficiently addressed within the development process as of yet? Thus far, there are no studies on record that explicitly examine the usability of Open Source Software in the field of Energy System Modelling. In this paper, we publish a novel method, the Energy System Modelling Usability Testing (ESMUT), including a step-by-step guide on how to apply the method and the corresponding usability questionnaire (ESMUQ). The questionnaire is based on the Post Study System Usability Questionnaire and adopted for quantitative usability testing of Open Source Energy System Modelling frameworks. To illustrate its usage and show its applicability, we apply the method in a case study with five frameworks (Balmorel, GENeSYS-MOD, GENESYS-2, oemof, and urbs) and within a group of eight framework developers. Based on the case study results, we find that the participants were largely satisfied in working with the frameworks analysed, and identify correct handling of input data and error messages as the most frequently mentioned problems when working with the frameworks. Consequently, we find that the usability of the frameworks analysed in the case study requires further improvement. Due to the fact that only the developer perspective was taken into account, and the number of participants involved in the study was limited, further research is required to assess the usability of Open Source Energy System Modelling frameworks.

Published
2022

6. Lipegfilgrastim for prophylaxis of chemotherapy-induced neutropenia in Dutch patients

Author

Timmer-Bonte, J.N.H., Ouwerkerk, J., Faber, L.M., Kerkhofs, L.G., Laterveer, L., Oever, D. Ten, Rees, B.P. van, and Linden, P.W. Van Der

Subjects
Other Research Radboud Institute for Health Sciences [Radboudumc 0]
Abstract

Item does not contain fulltext BACKGROUND: Chemotherapy (CT)-induced neutropenia and febrile neutropenia (FN) can lead to changes in the treatment plan, potentially worsening the cancer outcome. This study evaluated the effect of the glycopegylated granulocyte-colony stimulating factor lipegfilgrastim, used as primary (PP) or secondary prophylaxis (SP), on treatment modifications in adult patients receiving cytotoxic CT with or without biological/targeted therapy (BT) for solid and haematological tumours. METHODS: This phase 4, prospective, observational study was conducted in eight centres in the Netherlands, in 2015-2017. Other study objectives were to characterise the population of cancer patients receiving lipegfilgrastim, to evaluate the incidence of CT-induced neutropenic events, and to assess safety. RESULTS: Of 142 patients, 73.94% had breast cancer and 55.63% received CT in the adjuvant setting. Most patients received lipegfilgrastim as PP (74.65%) and were at low (34.51%) or high risk (39.44%) of FN. CT dose delays were recorded for 22.64% and 36.11% of patients receiving lipegfilgrastim for PP and SP, respectively. CT dose reductions were recorded for 2.11% of patients; no CT dose omissions and one BT dose omission occurred. FN and grade III/IV neutropenia were reported for 5.63% and 9.86% of patients, respectively; associated hospitalisations were rare. The most frequently lipegfilgrastimrelated adverse events (AE) were myalgia, bone pain, and back pain. Serious AEs (55) were reported for 30 (21.13%) patients. There were two deaths, unrelated to lipegfilgrastim administration. CONCLUSION: Administration of lipegfilgrastim in routine clinical practice in the Netherlands results in limited CT/BT dose modifications and low incidence of neutropenic events, with no new safety concerns.

Published
2020

9. Het materieelstrafrechtelijk legaliteitsbeginsel en bescherming van slachtoffers

Author

Strafrecht en strafprocesrecht 1, UCALL / Aansprakelijkheid en verantwoordelijkheid, Kristen, François, Kooijmans, T., Ouwerkerk, J., Rijken, C., J. Simmelink, Strafrecht en strafprocesrecht 1, UCALL / Aansprakelijkheid en verantwoordelijkheid, Kristen, François, Kooijmans, T., Ouwerkerk, J., Rijken, C., and J. Simmelink

Published
2021

19. Assessment of an optimistic bias in social media messages

Author

Suzana Bašić, Spijkers, Benthe S., Ouwerkerk, J. W., Vermeulen, I. E., Guido van Koningsbruggen, Antske Fokkens, and Vermeulen, Ivar

Subjects
SDG 10 - Reduced Inequalities
Abstract

Consistent with psychological theory and research, in the present study we demonstrate that people display a generic optimistic bias by showing more positive sentiment in social media messages about the future rather than the past. In addition, we outline a method for evaluating the validity of the commercial monitoring tool used for the automated sentiment analysis, thereby assessing the usefulness of such a tool in web-based research into human behavior.

Published
2018

20. Combination Chemotherapy in Advanced Adrenocortical Carcinoma

Author

Fassnacht, M., Terzolo, M., Allolio, B., Baudin, E., Haak, H., Berruti, A., Welin, S., Schade Brittinger, C., Lacroix, A., Jarzab, B., Sorbye, H., Torpy, D. J., Stepan, V., Schteingart, D. E., Arlt, W., Kroiss, M., Leboulleux, S., Sperone, P., Sundin, A., Hermsen, I., Hahner, S., Willenberg, H. S., Tabarin, A., Quinkler, M., De La Fouchardiere, C., Schlumberger, M., Mantero, F., Weismann, D., Beuschlein, F., Gelderblom, H., Wilmink, H., Sender, M., Edgerly, M., Kenn, W., Fojo, T., Muller, H. H., Skogseid, B., Haaf, M., Johanssen, S., Koschker, A. C., Laubner, K., Sbiera, S., Schiemann, J., Wortmann, S., Haase, M., Schott, M., Möhlig, M., Zopf, K., Reisch, N., Betz, M., Reincke, M., Isermann, B., Bornstein, S., Fottner, C., Bose, A., Petersenn, S., Leitolf, H., Klose, S., Wolf, H., Chougnet, C., More, J., Nunes, M. L., Droz, J. P., Nicolli, P., Chabre, O., Clergeot, A., Schillo, F., Penfornis, A., Do Cao, C., Goldwasser, F., Rodien, P., Ferrero, A., Perotti, P., Cicala Mv, Anna P., Della Casa, S., Mannelli, M., Piccini, V., Dercksen, M. W., Romijn, J. A., Ouwerkerk, J., Devries, J. H., Eriksson, B., Janson, E. T., Granberg, D., Oberg, K., Ahlman, H., Garkavij, M., Wall, N., Falkmer, U., Hammer, G., Olney, H. J., Bourdeau, I., Bourque, L., Szpak Ulczok, S., Jarzab, M., Holte, H., Fossa, A., Ploner, F., Mansmann, U., Schmoll, H. J., Simonsson, B., Toscano, Vincenzo, Petersenn, Stephan (Beitragende*r), CCA -Cancer Center Amsterdam, Oncology, Other departments, AGEM - Amsterdam Gastroenterology Endocrinology Metabolism, General Internal Medicine, and Endocrinology

Subjects
Adult, Male, adrenal tumor, medicine.medical_specialty, Medizin, Kaplan-Meier Estimate, Gastroenterology, Disease-Free Survival, Streptozocin, Young Adult, Internal medicine, Antineoplastic Combined Chemotherapy Protocols, Adrenocortical Carcinoma, Medicine, Adrenocortical carcinoma, Humans, Mitotane, Adverse effect, Etoposide, Aged, Intention-to-treat analysis, business.industry, Medicine (all), Hazard ratio, Combination chemotherapy, General Medicine, Middle Aged, medicine.disease, Adrenal Cortex Neoplasms, Surgery, Intention to Treat Analysis, Regimen, Doxorubicin, Cisplatin, Female, Quality of Life, business, medicine.drug
Abstract

A b s t r ac t Background Adrenocortical carcinoma is a rare cancer that has a poor response to cytotoxic treatment. Methods We randomly assigned 304 patients with advanced adrenocortical carcinoma to re ceive mitotane plus either a combination of etoposide (100 mg per square meter of body-surface area on days 2 to 4), doxorubicin (40 mg per square meter on day 1), and cisplatin (40 mg per square meter on days 3 and 4) (EDP) every 4 weeks or streptozocin (streptozotocin) (1 g on days 1 to 5 in cycle 1; 2 g on day 1 in subsequent cycles) every 3 weeks. Patients with disease progression received the alternative regimen as second-line therapy. The primary end point was overall survival. Results For first-line therapy, patients in the EDP–mitotane group had a significantly higher response rate than those in the streptozocin–mitotane group (23.2% vs. 9.2%, P

Published
2012
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21. Woord vooraf

Author

Sub Strafrecht, Montaigne Centrum voor Rechtspleging en conflictoplossing, UU LEG LAW Landelijke Onderzoekschool Rechten van de Mens, Claessen, J., Jacobs, Pauline, Meijer, S., Ouwerkerk, J, Jacobs, P., Ouwerkerk, J., Sub Strafrecht, Montaigne Centrum voor Rechtspleging en conflictoplossing, UU LEG LAW Landelijke Onderzoekschool Rechten van de Mens, Claessen, J., Jacobs, Pauline, Meijer, S., Ouwerkerk, J, Jacobs, P., and Ouwerkerk, J.

Published
2014

22. Woord vooraf

Author

Claessen, J., Jacobs, Pauline, Meijer, S., Ouwerkerk, J, Jacobs, P., Ouwerkerk, J., Sub Strafrecht, Montaigne Centrum voor Rechtspleging en conflictoplossing, and UU LEG LAW Landelijke Onderzoekschool Rechten van de Mens

Published
2014

24. Vergelding en verzoening versus wraak en vergeving

Author

Tongeren, P.J.M. van, Ouwerkerk, J., De Wit, Th., Ouwerker, J., Wit, Th. de, Ouwerkerk, J., and De Wit, Th.

Subjects
Center for Contemporary European Philosophy (CCEP)
Abstract

Item does not contain fulltext

Published
2013

25. Central venous access related adverse events after trabectedin infusions in soft tissue sarcoma patients; experience and management in a nationwide multi-center study

Author

Verboom, M.C., Ouwerkerk, J., Steeghs, N., Lutjeboer, J., Kerst, J.M., Graaf, W.T.A. van der, Reyners, A.K., Sleijfer, S., Gelderblom, H., Verboom, M.C., Ouwerkerk, J., Steeghs, N., Lutjeboer, J., Kerst, J.M., Graaf, W.T.A. van der, Reyners, A.K., Sleijfer, S., and Gelderblom, H.

Abstract

Contains fulltext : 170362.pdf (publisher's version ) (Open Access), BACKGROUND: Trabectedin has shown efficacy against soft tissue sarcomas (STS) and has manageable toxicity. Trabectedin is administered through central venous access devices (VAD), such as subcutaneous ports with tunneled catheters, Hickman catheters and PICC lines. Venous access related adverse events are common, but have not yet been reported in detail. METHODS: A retrospective analysis of patient files of STS patients receiving trabectedin monotherapy between 1999 and 2014 was performed in all five STS referral centers in the Netherlands. This survey focused on adverse events related to the VAD and the actions taken in response to these events. RESULTS: In the 127 patients included in this analysis, 102 venous access ports (VAP), 15 Hickman catheters and 10 PICC lines were used as primary means of central venous access. The most frequently reported adverse events at the VAD site were erythema (30.7%), pain (28.3%), inflammation (11.8%) and thrombosis (11.0%). Actions taken towards these adverse events include oral antibiotics (17.3%), VAD replacement (15.0%) or a wait-and-see policy (13.4%). In total, 45 patients (35.4%) with a subcutaneous port developed a varying degree of inflammation along the trajectory of the tunneled catheter. In all but three patients, this was a sterile inflammation, which was considered a unique phenomenon for trabectedin. Microscopic leakage of trabectedin along the venous access device and catheter was considered the most plausible cause for this adverse event. Placing the catheter deeper under the skin resolved the issue almost completely. CONCLUSION: Trabectedin infusion commonly leads to central venous access related adverse events. Sterile inflammation along the catheter trajectory is one of the most common adverse events and can be prevented by placing the catheter deeper under the skin.

Published
2017

28. Imitatie en liking: Een functionele benadering

Author

Stel, M., Baaren, R.B. van, Blascovich, J., McCall, C., Pollmann, M.M.H., Leeuwen, M.L. van, Vonk, R., Holland, R.W., Ouwerkerk, J., Laar, C. van, Ruiter, R., Ham, J.R.C., Holland, R.W., Ouwerkerk, J., Laar, C. van, Ruiter, R., and Ham, J.R.C.

Subjects
Behaviour Change and Well-being
Abstract

Item does not contain fulltext

Published
2006

29. Wanneer onbewuste doelen bewust worden

Author

Bongers, K.C.A., Dijksterhuis, A.J., Spears, R., Holland, R.W., Ouwerkerk, J., Laar, C., Ruiter, R., Ham, R.J.C., Holland, R.W., Ouwerkerk, J., Laar, C., Ruiter, R., and Ham, R.J.C.

Subjects
Behaviour Change and Well-being
Abstract

Item does not contain fulltext

Published
2006

30. Affect en intuïtief beslissen

Author

Vries, M. de, Holland, R.W., Witteman, C.L.M., Ouwerkerk, J., Laar, C. van, Ruiter, R., Ham, J.R.C., Holland, R.W., Ouwerkerk, J., Laar, C. van, Ruiter, R., and Ham, J.R.C.

Subjects
Experimental Psychopathology and Treatment, Behaviour Change and Well-being
Abstract

Item does not contain fulltext

Published
2006

31. Effecten van relatie-ervaringen op hechtingsstijl

Author

Kroesbergen, W., Vonk, R., Holland, R.W., Ouwerkerk, J., Laar, C. van, Ruiter, R., Ham, J.R.C., Holland, R.W., Ouwerkerk, J., Laar, C. van, Ruiter, R., and Ham, J.R.C.

Subjects
Behaviour Change and Well-being
Abstract

Item does not contain fulltext

Published
2006

35. La matrice relazionale della Schadenfreude

Author

Van Dijk, W. W., Ouwerkerk, J. W., Cigoli, Vittorio, Facchin, Federica, Cigoli, Vittorio (ORCID:0000-0002-1136-3830), Facchin, Federica (ORCID:0000-0001-8944-1440), Van Dijk, W. W., Ouwerkerk, J. W., Cigoli, Vittorio, Facchin, Federica, Cigoli, Vittorio (ORCID:0000-0002-1136-3830), and Facchin, Federica (ORCID:0000-0001-8944-1440)

Abstract

N/A

Published
2016

36. Mensbeelden en strafrecht (foto- en interviewboek)

Author

Claessen, J., Jacobs, Pauline, Meijer, S., Ouwerkerk, J, Sub Strafrecht, Montaigne Centrum voor Rechtspleging en conflictoplossing, and UU LEG LAW Landelijke Onderzoekschool Rechten van de Mens

Published
2014

37. Mensbeelden in het strafrecht

Author

Meijer, S., Ouwerkerk, J., Claessen, J.A.A.C., Jacobs, P., Criminal Law, Network Institute, Communication Choices, Content and Consequences (CCCC), Empirical and Normative Studies, and Kooijmans Institute

Published
2014

38. Pedofielen blijven mensen

Author

Claessen, J.A.A.C., Ouwerkerk, J., de Haas, A., Criminal Law and Criminology, RS: FdR RvdM Strafrecht en Crim., RS: FdR Strafrecht en Criminologie, and RS: FdR Institute MCfHR

Published
2013

48. Inleiding

Author

Claessen, J.A.A.C., Ouwerkerk, J., de Wit, Th., Jacobs, P., Meijer, S., Criminal Law and Criminology, RS: FdR RvdM Strafrecht en Crim., RS: FdR Strafrecht en Criminologie, and RS: FdR Institute MCfHR

Published
2013

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