Search

Your search keyword '"Outi Leskinen"' showing total 3 results
Start Over Author "Outi Leskinen"
3 results on '"Outi Leskinen"'

1. Impaired Bone Health in Children With Biliary Atresia

Author

Satu Ruuska, Kaija-Leena Kolho, Anna Hagfors, Hannu Jalanko, Outi Leskinen, Saila Laakso, and Mikko P. Pakarinen

Subjects
Pediatrics, medicine.medical_specialty, Adolescent, Bone density, medicine.medical_treatment, Rickets, Liver transplantation, 03 medical and health sciences, Absorptiometry, Photon, 0302 clinical medicine, Biliary Atresia, Bone Density, Biliary atresia, Interquartile range, 030225 pediatrics, Humans, Medicine, Child, Finland, Retrospective Studies, Bone mineral, business.industry, Gastroenterology, Infant, Gestational age, Bone fracture, medicine.disease, 3. Good health, Pediatrics, Perinatology and Child Health, 030211 gastroenterology & hepatology, business
Abstract

OBJECTIVES The aim of the study was to examine the frequency of rickets and bone fractures and to assess areal bone mineral density (aBMD) in childhood among patients with biliary atresia (BA). METHODS We gathered data on all patients diagnosed with BA in Finland that survived to ≥1 year of age between 1 January 2000 to 30 June 2018. Data on gestational age, birth weight, postsurgical medications, and history of rickets and bone fractures were collected retrospectively. Serum levels of 25-hydroxyvitamin D [25(OH)D] postportoenterostomy (PE) were collected. Plain radiographs and dual energy X-ray absorptiometry (DXA) measurements of study subjects were reviewed. RESULTS Out of 49 patients, 7 (14%) were diagnosed with rickets during infancy. Clearance of jaundice [odds ratio 0.055, 95% confidence interval [CI] 0.00266-0.393; P

Published
2020
Full Text
View/download PDF

2. Incidence and long-term outcomes of surgically treated childhood hepatic malignancies in Finland

Author

Jukka Kanerva, Heikki Mäkisalo, Maria Hukkinen, Tea Soini, Timo Jahnukainen, Mikko P. Pakarinen, Markku Heikinheimo, Toivo Tiusanen, Outi Leskinen, Children's Hospital, HUS Children and Adolescents, Helsinki University Hospital Area, Clinicum, Lastenkirurgian yksikkö, HUS Medical Imaging Center, HUS Abdominal Center, IV kirurgian klinikka, Department of Surgery, and Helsinki One Health (HOH)

Subjects
medicine.medical_specialty, Hepatoblastoma, medicine.medical_treatment, Liver transplantation, Malignancy, Gastroenterology, liver cancer, 03 medical and health sciences, 0302 clinical medicine, children, Interquartile range, 3123 Gynaecology and paediatrics, Internal medicine, medicine, Undifferentiated (Embryonal) Sarcoma, Humans, Child, Finland, Aged, 030304 developmental biology, 0303 health sciences, liver transplantation, business.industry, Incidence, Incidence (epidemiology), Liver Neoplasms, HEPATOBLASTOMA, Infant, General Medicine, hepatocellular carcinoma, medicine.disease, LIVER-TRANSPLANTATION, CANCER, TUMORS, 3. Good health, Treatment Outcome, Child, Preschool, 030220 oncology & carcinogenesis, Hepatocellular carcinoma, Pediatrics, Perinatology and Child Health, SURVIVAL, Liver cancer, business, SYSTEM
Abstract

Aim To analyse incidence, treatment and outcomes of paediatric liver malignancies in Finland during 1987-2017. Methods Medical records and national cancer registry data of 47 children with liver malignancies were reviewed. Survival was calculated with the Kaplan-Meier method. Results During follow-up, liver malignancy incidence remained stable at 1.1:10(6). Altogether, 42 patients with hepatoblastoma (n = 24), hepatocellular carcinoma (n = 11) and undifferentiated embryonal sarcoma (n = 7) underwent surgery at median age 4.6 (interquartile range, 2.0-9.6) years and were followed up for 13 (7.0-19) years. Cumulative 5-year survival was 86% for hepatoblastoma, 41% for hepatocellular carcinoma and 67% for undifferentiated embryonal sarcoma. Five-year survival was decreased among hepatoblastoma patients aged >= 2.4 years (73% versus 100%, P = .040), with PRETreatment EXTent of disease IV (PRETEXT, 60% vs 100%, P = .004), and with recurrent disease (67% vs 88%, P = .029). Recurrent/residual disease associated with decreased 5-year survival in hepatocellular carcinoma (0% vs 83%, P = .028). Survival was similar among 19 transplanted and 23 resected patients. In total, 14 deaths occurred either for the underlying malignancy (n = 8), adverse effects of chemotherapy (n = 5) or unrelated reasons (n = 1). Conclusion Outcomes for PRETEXT I-III hepatoblastoma and un-metastasized hepatocellular carcinoma were encouraging. Adverse effects of chemotherapy significantly contributed to mortality.

Published
2020

3. Effect of Wilms tumor histology on response to neoadjuvant chemotherapy

Author

Seppo Taskinen, Minna Koskenvuo, Outi Leskinen, Jouko Lohi, Mervi Taskinen, Lastenkirurgian yksikkö, Children's Hospital, Clinicum, HUS Children and Adolescents, HUS Medical Imaging Center, Department of Diagnostics and Therapeutics, Department of Pathology, Medicum, Helsinki University Hospital Area, Hematologian yksikkö, Department of Oncology, Lastentautien yksikkö, and HUS Comprehensive Cancer Center

Subjects
Male, medicine.medical_treatment, SURGICAL COMPLICATIONS, Kidney, Nephrectomy, PREDICT, IMMEDIATE NEPHRECTOMY, 0302 clinical medicine, Wilms' tumor, 3123 Gynaecology and paediatrics, Antineoplastic Combined Chemotherapy Protocols, Preoperative chemotherapy, Tumor volume, Child, Neoadjuvant therapy, UKW3, medicine.diagnostic_test, PREOPERATIVE CHEMOTHERAPY, General Medicine, Kidney Neoplasms, Neoadjuvant Therapy, 3. Good health, Treatment Outcome, 030220 oncology & carcinogenesis, Child, Preschool, BIOPSY, TRIAL, Female, Radiology, NEPHROBLASTOMA, medicine.medical_specialty, Histology, Wilms Tumor, 03 medical and health sciences, 030225 pediatrics, Biopsy, medicine, MANAGEMENT, Chemotherapy, Humans, Retrospective Studies, business.industry, Infant, Retrospective cohort study, medicine.disease, 3126 Surgery, anesthesiology, intensive care, radiology, Pediatrics, Perinatology and Child Health, VOLUME, Surgery, business
Abstract

Purpose: To evaluate the association between Wilms tumor histology at diagnosis and the change in Wilms' tumor volume during preoperative chemotherapy. Methods: We included all the 52 patients operated for Wilms tumor at 1988-2015, who had both pathology samples and either CT or MRI-images before and after preoperative chemotherapy, available for reevaluation. Results: The median tumor volume was 586 ml (IQR 323-903) at diagnosis. The median change in tumor volume was -68% (IQR -85 to -40, p

Published
2018

Catalog

Books, media, physical & digital resources
See catalog results