4,390 results on '"Outcome Assessment (Health Care)"'
Search Results
2. Prospective Registry of Mobilization-, Routine- and Outcome Data of Intensive Care Patients (MOBDB)
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Stefan Schaller, Senior Specialist Intensive Care
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- 2023
3. How intervention studies measure the effectiveness of medication safety-related clinical decision support systems in primary and long-term care: a systematic review
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David Lampe, John Grosser, Dennis Grothe, Birthe Aufenberg, Daniel Gensorowsky, Julian Witte, and Wolfgang Greiner
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Systematic review ,Medical Order Entry systems ,Decision support systems, clinical ,Outcome Assessment (Health Care) ,Medication errors ,Primary Health Care ,Computer applications to medicine. Medical informatics ,R858-859.7 - Abstract
Abstract Background Medication errors and associated adverse drug events (ADE) are a major cause of morbidity and mortality worldwide. In recent years, the prevention of medication errors has become a high priority in healthcare systems. In order to improve medication safety, computerized Clinical Decision Support Systems (CDSS) are increasingly being integrated into the medication process. Accordingly, a growing number of studies have investigated the medication safety-related effectiveness of CDSS. However, the outcome measures used are heterogeneous, leading to unclear evidence. The primary aim of this study is to summarize and categorize the outcomes used in interventional studies evaluating the effects of CDSS on medication safety in primary and long-term care. Methods We systematically searched PubMed, Embase, CINAHL, and Cochrane Library for interventional studies evaluating the effects of CDSS targeting medication safety and patient-related outcomes. We extracted methodological characteristics, outcomes and empirical findings from the included studies. Outcomes were assigned to three main categories: process-related, harm-related, and cost-related. Risk of bias was assessed using the Evidence Project risk of bias tool. Results Thirty-two studies met the inclusion criteria. Almost all studies (n = 31) used process-related outcomes, followed by harm-related outcomes (n = 11). Only three studies used cost-related outcomes. Most studies used outcomes from only one category and no study used outcomes from all three categories. The definition and operationalization of outcomes varied widely between the included studies, even within outcome categories. Overall, evidence on CDSS effectiveness was mixed. A significant intervention effect was demonstrated by nine of fifteen studies with process-related primary outcomes (60%) but only one out of five studies with harm-related primary outcomes (20%). The included studies faced a number of methodological problems that limit the comparability and generalizability of their results. Conclusions Evidence on the effectiveness of CDSS is currently inconclusive due in part to inconsistent outcome definitions and methodological problems in the literature. Additional high-quality studies are therefore needed to provide a comprehensive account of CDSS effectiveness. These studies should follow established methodological guidelines and recommendations and use a comprehensive set of harm-, process- and cost-related outcomes with agreed-upon and consistent definitions. Prospero registration CRD42023464746
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- 2024
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- View/download PDF
4. How intervention studies measure the effectiveness of medication safety-related clinical decision support systems in primary and long-term care: a systematic review.
- Author
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Lampe, David, Grosser, John, Grothe, Dennis, Aufenberg, Birthe, Gensorowsky, Daniel, Witte, Julian, and Greiner, Wolfgang
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CLINICAL decision support systems , *LONG-term health care , *MEDICATION error prevention , *CLINICAL trials - Abstract
Background: Medication errors and associated adverse drug events (ADE) are a major cause of morbidity and mortality worldwide. In recent years, the prevention of medication errors has become a high priority in healthcare systems. In order to improve medication safety, computerized Clinical Decision Support Systems (CDSS) are increasingly being integrated into the medication process. Accordingly, a growing number of studies have investigated the medication safety-related effectiveness of CDSS. However, the outcome measures used are heterogeneous, leading to unclear evidence. The primary aim of this study is to summarize and categorize the outcomes used in interventional studies evaluating the effects of CDSS on medication safety in primary and long-term care. Methods: We systematically searched PubMed, Embase, CINAHL, and Cochrane Library for interventional studies evaluating the effects of CDSS targeting medication safety and patient-related outcomes. We extracted methodological characteristics, outcomes and empirical findings from the included studies. Outcomes were assigned to three main categories: process-related, harm-related, and cost-related. Risk of bias was assessed using the Evidence Project risk of bias tool. Results: Thirty-two studies met the inclusion criteria. Almost all studies (n = 31) used process-related outcomes, followed by harm-related outcomes (n = 11). Only three studies used cost-related outcomes. Most studies used outcomes from only one category and no study used outcomes from all three categories. The definition and operationalization of outcomes varied widely between the included studies, even within outcome categories. Overall, evidence on CDSS effectiveness was mixed. A significant intervention effect was demonstrated by nine of fifteen studies with process-related primary outcomes (60%) but only one out of five studies with harm-related primary outcomes (20%). The included studies faced a number of methodological problems that limit the comparability and generalizability of their results. Conclusions: Evidence on the effectiveness of CDSS is currently inconclusive due in part to inconsistent outcome definitions and methodological problems in the literature. Additional high-quality studies are therefore needed to provide a comprehensive account of CDSS effectiveness. These studies should follow established methodological guidelines and recommendations and use a comprehensive set of harm-, process- and cost-related outcomes with agreed-upon and consistent definitions. Prospero registration: CRD42023464746 [ABSTRACT FROM AUTHOR]
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- 2024
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5. Providing evidence for content validity of the most frequently used hip specific recovery outcome measures in hip fracture studies: an International Classification of Functioning approach.
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Randa, Lora, Sharma-Sharma, Shubhangi, Franz, Martina, and Auais, Mohammad
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HIP fractures , *CINAHL database , *PHYSICIANS' attitudes , *TREATMENT effectiveness , *SYSTEMATIC reviews , *MEDLINE , *CONVALESCENCE , *HEALTH outcome assessment , *ONLINE information services , *NOSOLOGY ,RESEARCH evaluation - Abstract
We established the most commonly used clinician and patient-reported hip fracture outcome measures as of 2022, assessed their content validity using an International Classification of Functioning, Disability and Health (ICF) framework, and operationalized these results to contribute to an updated hip fracture core set. A literature search was conducted to identify articles utilizing outcome measures related to hip fracture. A total of five outcome measures were identified, linked to the ICF, and assessed for content validity via bandwidth percent, content density, and content diversity. Outcome measures were linked to 191 ICF codes, most of which were associated with Activities and Participation. Notably, no outcome measure contained concepts linked to Personal Factors and Environmental Factors were underrepresented across all outcome measures. The modified Harris Hip Score had the highest content diversity (0.67), the Hip Disability and Osteoarthritis Outcome Score had the highest bandwidth of ICF content coverage (2.48), and the Oxford Hip Score had the highest content density (2.92). These results clarify the clinical applicability of outcome measures and guide development of hip fracture outcomes that allow providers to assess the complex role of social, environmental, and personal factors in patient rehabilitation. Hip fracture is a complex and disabling pathology predominantly affecting older adults and represents a public health problem. There are a variety of outcome measures used to assess a patient's recovery following a hip fracture, each with distinctive objectives and modes of administration. Content validity metrics associated with the Harris Hip Score suggest it would be a suitable outcome measure during early-stage recovery, whereas the modified Harris Hip Score may be more suitable for tracking long-term recovery tracking. Choosing an outcome measure most appropriate for a hip fracture patient is an individualized decision that must consider aspects such as age, activity level, needs, and environmental factors. [ABSTRACT FROM AUTHOR]
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- 2024
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6. Towards a core outcome set for dysarthria after stroke: What should we measure?
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Mitchell, Claire, Woodward-Nutt, Kate, Dancer, Annette, Taylor, Stephen, Bugler, Joe, Bowen, Audrey, Conroy, Paul, Whelan, Brooke-Mai, Wallace, Sarah J, El Kouaissi, Sabrina, and Kirkham, Jamie
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WORLD Wide Web , *CONSENSUS (Social sciences) , *DYSARTHRIA , *RESEARCH funding , *EVALUATION of medical care , *DESCRIPTIVE statistics , *SURVEYS , *STROKE patients , *MEDICAL needs assessment , *DELPHI method , *HEALTH outcome assessment , *PSYCHOSOCIAL factors - Abstract
Objective: To identify and agree on what outcome domains should be measured in research and clinical practice when working with stroke survivors who have dysarthria. Design: Delphi process, two rounds of an online survey followed by two online consensus meetings. Setting: UK and Australia. Participants: Stroke survivors with experience of dysarthria, speech and language therapists/pathologists working in stroke and communication researchers. Methods: Initial list of outcome domains generated from existing literature and with our patient and public involvement group to develop the survey. Participants completed two rounds of this survey to rate importance. Outcomes were identified as 'in', 'unclear' or 'out' from the second survey. All participants were invited to two consensus meetings to discuss these results followed by voting to identify critically important outcome domains for a future Core Outcome Set. All outcomes were voted on in the consensus meetings and included if 70% of meeting participants voted 'yes' for critically important. Results: In total, 148 surveys were fully completed, and 28 participants attended the consensus meetings. A core outcome set for dysarthria after stroke should include four outcome domains: (a) intelligibility of speech, (b) ability to participate in conversations, (c) living well with dysarthria, (d) skills and knowledge of communication partners (where relevant). Conclusions: We describe the consensus of 'what' speech outcomes after stroke are valued by all stakeholders including those with lived experience. We share these findings to encourage the measurement of these domains in clinical practice and research and for future research to identify 'how' best to measure these outcomes. [ABSTRACT FROM AUTHOR]
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- 2024
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7. Colorectal cancer treatment outcomes during the pandemic: Our experience of COVID‐19 at a tertiary referral center.
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Kei, Christy, Gartrell, Richard, Arafat, Yasser, Degabriele, Elizabeth, Yeung, Josephine, Chan, Steven, Faragher, Ian, and Yeung, Justin M. C.
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COVID-19 pandemic , *COLORECTAL cancer , *COVID-19 , *CANCER treatment , *PANDEMICS - Abstract
Backgrounds: The coronavirus disease 2019 (COVID‐19) has led to major shifts in the management of colorectal cancer (CRC). This study aims to identify the impact and early outcomes of COVID‐19 following CRC management at a tertiary referral center in Victoria, Australia. Methods: This was a retrospective study, utilizing the Australian Comprehensive Cancer Outcomes and Research Database and inpatient records. Patients presenting for CRC management at our institution were identified coinciding with the first Victorian outbreak of COVID‐19 (March 26 to September 26, 2020) (COVID). Management decisions including chemoradiotherapy utilization and surgical outcomes were analyzed within 6 months and compared with the corresponding period in 2019 (pre‐COVID). Results: A total of 276 patients were included in this study (147 pre‐COVID period, 129 COVID period). During the COVID period, more patients (47.6% vs. 60.5%; p = 0.033) presented symptomatically and less for surveillance (10.9% vs. 2.3%; p < 0.01). Eighty‐four pre‐COVID and 69 COVID period patients proceeded to surgery. The average time from diagnosis date to surgery was 15.6 days less during the COVID period. There were no significant differences in postoperative utilization of higher care (p = 0.74), complications (p = 0.93), median hospital length of stay (p = 0.67), 30‐day readmission (p = 0.50), or 30‐day reoperation (p = 0.74). In 1.6% of cases, pandemic impacts resulted in a change in management. Conclusion: Presentation of patients with CRC varied, with a significant increase in symptomatic presentations and decreased numbers for surveillance. Through flexibility and change in practice, our institution helped improve access to surgical intervention and oncological therapies. Further prospective work is required to identify long‐term outcomes and characterize the effects of ongoing disruptions. [ABSTRACT FROM AUTHOR]
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- 2024
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8. Predicting Discharge Destination in Older People From Acute General Medical Wards: A Systematic Review of the Psychometric Properties of 23 Assessment Tools.
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D'Souza, Aruska N., Granger, Catherine L., Leggett, Nina E., Tomkins, Melanie S., Kay, Jacqueline E., and Said, Catherine M.
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MEDICAL information storage & retrieval systems ,FAMILY medicine ,RESEARCH methodology evaluation ,CINAHL database ,RESEARCH evaluation ,QUESTIONNAIRES ,DISCHARGE planning ,SYSTEMATIC reviews ,MEDLINE ,PSYCHOMETRICS ,BARTHEL Index ,HEALTH outcome assessment ,PATIENT satisfaction ,HOSPITAL wards ,OLD age - Abstract
Background: Predicting discharge in older people from general medicine wards is challenging. It requires consideration of function, mobility, and cognitive levels, which vary within the cohort and may fluctuate over a short period. A previous systematic review identified 23 assessment tools associated with discharge destination in this cohort; however, the psychometric properties of these tools have not been explored. Purpose: To evaluate, synthesize, and compare the psychometric properties of 23 assessment tools used to predict discharge destination from acute general medical wards. Methods: Four databases were systematically searched: Medline (Ovid), Embase (Ovid), Cumulative Index of Nursing and Allied Health Literature (CINAHL), and Evidence-Based Medicine Review databases. Studies were included if participants were from general medicine or acute geriatric wards and investigated at least one psychometric property (reliability, internal consistency, measurement error, responsiveness, hypothesis testing, and structural or criterion validity) in 23 previously identified assessment tools. Data were extracted and methodological quality were assessed independently by 2 assessors using the COnsensus-based Standards for selection of health Measure INstruments (COSMIN) checklist. As per the COSMIN checklist, results were rated against "sufficient," "insufficient," or "indeterminate." Results: Forty-one studies were included. The de Morton Mobility Index (DEMMI) was the most rigorously evaluated assessment tool; it scored "sufficient" psychometric properties in 5 of 7 psychometric categories. The Alpha Functional Independence Measure (AlphaFIM), Barthel Index, and Mini-Mental State Examination (MMSE) demonstrated "sufficient" psychometric properties in at least 3 psychometric categories. The remainder of the tools (n = 19, 83%) had "sufficient" psychometric properties in 2 or fewer psychometric categories. Discussion and Conclusion: Based on current evidence, out of 23 assessment tools associated with discharge destination in acute general medicine, the DEMMI has the strongest psychometric properties. Other tools with substantial evidence in this cohort include the AlphaFIM, MMSE, and Barthel Index. Research is required to thoroughly evaluate the psychometric properties of the remaining tools, which have been insufficiently researched to date. Results can be used by physical therapists to guide selection of appropriate tools to assess mobility and predict discharge destination. Trial Registration: A priori, PROSPERO (CRD 42017064209). [ABSTRACT FROM AUTHOR]
- Published
- 2024
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9. Early Prediction of Poststroke Rehabilitation Outcomes Using Wearable Sensors.
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O'Brien, Megan K, Lanotte, Francesco, Khazanchi, Rushmin, Shin, Sung Yul, Lieber, Richard L, Ghaffari, Roozbeh, Rogers, John A, and Jayaraman, Arun
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STROKE prognosis , *MEDICAL protocols , *RESEARCH funding , *WEARABLE technology , *FUNCTIONAL status , *EVALUATION of medical care , *DESCRIPTIVE statistics , *DIAGNOSIS , *GAIT in humans , *DECISION making , *ASSISTIVE technology , *STROKE rehabilitation , *MACHINE learning , *COMPUTER assisted instruction , *ACCIDENTAL falls , *POSTURAL balance , *ALGORITHMS - Abstract
Objective Inpatient rehabilitation represents a critical setting for stroke treatment, providing intensive, targeted therapy and task-specific practice to minimize a patient's functional deficits and facilitate their reintegration into the community. However, impairment and recovery vary greatly after stroke, making it difficult to predict a patient's future outcomes or response to treatment. In this study, the authors examined the value of early-stage wearable sensor data to predict 3 functional outcomes (ambulation, independence, and risk of falling) at rehabilitation discharge. Methods Fifty-five individuals undergoing inpatient stroke rehabilitation participated in this study. Supervised machine learning classifiers were retrospectively trained to predict discharge outcomes using data collected at hospital admission, including patient information, functional assessment scores, and inertial sensor data from the lower limbs during gait and/or balance tasks. Model performance was compared across different data combinations and was benchmarked against a traditional model trained without sensor data. Results For patients who were ambulatory at admission, sensor data improved the predictions of ambulation and risk of falling (with weighted F1 scores increasing by 19.6% and 23.4%, respectively) and maintained similar performance for predictions of independence, compared to a benchmark model without sensor data. The best-performing sensor-based models predicted discharge ambulation (community vs household), independence (high vs low), and risk of falling (normal vs high) with accuracies of 84.4%, 68.8%, and 65.9%, respectively. Most misclassifications occurred with admission or discharge scores near the classification boundary. For patients who were nonambulatory at admission, sensor data recorded during simple balance tasks did not offer predictive value over the benchmark models. Conclusion These findings support the continued investigation of wearable sensors as an accessible, easy-to-use tool to predict the functional recovery after stroke. Impact Accurate, early prediction of poststroke rehabilitation outcomes from wearable sensors would improve our ability to deliver personalized, effective care and discharge planning in the inpatient setting and beyond. [ABSTRACT FROM AUTHOR]
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- 2024
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10. Heterogeneity of Tasks and Outcome Measures in Dual Tasking Studies in Children With Cerebral Palsy: A Scoping Review.
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Rubsam, Meaghan, Girolami, Gay L, and Bhatt, Tanvi
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EVALUATION of medical care , *ONLINE information services , *CINAHL database , *SYSTEMATIC reviews , *POSTURAL balance , *FUNCTIONAL status , *TASK performance , *HUMAN multitasking , *WALKING , *CEREBRAL palsy , *COGNITIVE testing , *LITERATURE reviews , *MEDLINE , *MOTOR ability , *CHILDREN - Abstract
Objective The aims of this scoping review are to examine the available literature regarding dual tasking in children with cerebral palsy (CP) and to identify and categorize both the motor and cognitive tasks and outcome measures used primarily through the International Classification of Functioning, Disability, and Health model. Methods Five electronic databases were searched. Studies were included if they: (1) were published in English; (2) included at least 1 group of children or adolescents with a diagnosis of CP; (3) assessed dual tasking as part of the study; (4) reported the method for performing the dual task; and (5) reported the outcome measures utilized. Results Twenty-three studies with 439 children with CP were included. All studies utilized motor activities as the primary task, including walking, balance, and a functional transition. Motor secondary tasks occurred in 10 studies, cognitive secondary tasks in 12 studies, and 1 study used both. Forty-one outcome measures over 23 studies assessed the body structure and function domain, 7 measures over 6 studies assessed activity limitations, and 2 outcomes over 2 studies assessed participation. Conclusion The 23 included studies demonstrated heterogeneity in the age and function of participants, secondary tasks, and outcome measures. Future studies on dual tasking in children with CP should consider the difficulty of the primary motor or cognitive task and compare secondary tasks to establish this contribution to motor performance. Studies should incorporate activity and participation measures to assess meaningful functional outcomes. Impact Children with CP experience challenges when exposed to dual task situations. This scoping review highlights the importance of considering multiple factors when designing dual tasking studies involving children with CP to facilitate results translation, improved participation, and enhanced function. Similarly, studies should utilize activity and participation outcomes to assess quality of life. [ABSTRACT FROM AUTHOR]
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- 2024
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11. The Psychometric Properties of the 9-Item Vestibular Activities Avoidance Instrument.
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Dunlap, Pamela M, Alradady, Fai A, Costa, Claudia M, Delitto, Anthony, Terhorst, Lauren, Sparto, Patrick J, Furman, Joseph M, Marchetti, Gregory F, Staab, Jeffrey P, Chueh, Jasmine, and Whitney, Susan L
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STATISTICS , *PHOBIAS , *CONFIDENCE , *STATISTICAL reliability , *CONFIDENCE intervals , *PREDICTIVE tests , *RESEARCH methodology evaluation , *RESEARCH methodology , *DIZZINESS , *FUNCTIONAL status , *SELF-perception , *POSTURAL balance , *HEALTH outcome assessment , *VESTIBULAR apparatus diseases , *MANN Whitney U Test , *PSYCHOMETRICS , *AVOIDANCE (Psychology) , *PSYCHOLOGICAL tests , *CRONBACH'S alpha , *RISK assessment , *BODY movement , *QUESTIONNAIRES , *DESCRIPTIVE statistics , *INTRACLASS correlation , *MENTAL depression , *DISABILITIES , *DATA analysis software , *DATA analysis , *ANXIETY , *PAIN catastrophizing , *RECEIVER operating characteristic curves , *SENSITIVITY & specificity (Statistics) , *PREDICTIVE validity , *EVALUATION ,RESEARCH evaluation - Abstract
Objective The purpose of this study was to establish the psychometric properties of the 9-Item Vestibular Activities Avoidance Instrument (VAAI-9), a patient-reported outcome measure developed to identify fear avoidance beliefs in persons with vestibular disorders. Methods This prospective cohort study included 100 participants 18 years and older seeking care at a balance disorders clinic for dizziness. Participants completed the VAAI-9, the Dizziness Handicap Inventory (DHI), and other patient-reported outcomes at the initial visit and the 3-month follow-up. To measure test–retest reliability, the VAAI-9 was completed again 5 days after the initial visit and was analyzed using a 2-way mixed ICC for absolute agreement. Internal consistency was determined using the Cronbach alpha. The Spearman correlation coefficient was used to assess convergent validity of the VAAI-9 with other outcomes. Receiver operating characteristic curves were used to identify baseline VAAI-9 cutoff scores for those who reported mild (DHI ≤ 30) or moderate or severe (DHI > 30) perceived disability at the 3-month follow-up. Results The mean age of the study cohort was 49 (SD = 16) years; 73 (73%) were women. Seventy-one participants completed the 5-day follow-up, and 68 completed the 3-month follow-up. The VAAI-9 demonstrated excellent internal consistency (α = 0.91) and test–retest reliability (ICC = 0.90). Baseline VAAI-9 scores had moderate to strong associations with other outcome measures at baseline and 3 months. A baseline VAAI-9 score of 26 or higher had a sensitivity of 80.6% and a specificity of 78.4% for identifying a DHI score of >30 at 3 months (area under the curve = 0.86). Conclusions The results provide evidence of excellent reliability and validity for the 9-item VAAI in persons with vestibular disorders. A baseline VAAI-9 score of ≥26 identified individuals at risk of persistent moderate to severe disability due to dizziness. Impact Initial levels of fear avoidance beliefs measured using the VAAI-9 provided important prognostic information about outcomes for persons with vestibular symptoms. [ABSTRACT FROM AUTHOR]
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- 2023
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12. Assessing the Measurement Properties of the Self-Administered Amyotrophic Lateral Sclerosis Functional Rating Scale–Revised (ALSFRS-R): A Rasch Analysis.
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Mehdipour, Ava, Teshler, Lizabeth, Bello-Haas, Vanina Dal, Richardson, Julie, Beauchamp, Marla, Turnbull, John, Chum, Marvin, Johnston, Wendy, O'Connell, Colleen, Luth, Westerly, and Kuspinar, Ayse
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STATISTICS , *DISEASE progression , *RELIABILITY (Personality trait) , *STATISTICAL reliability , *RESEARCH methodology evaluation , *MOTOR neuron diseases , *HEALTH outcome assessment , *FUNCTIONAL assessment , *SELF medication , *PSYCHOMETRICS , *AMYOTROPHIC lateral sclerosis , *CHI-squared test , *DATA analysis , *DISEASE management , *EVALUATION - Abstract
Objective The self-administered version of the Amyotrophic Lateral Sclerosis Functional Rating Scale–Revised (ALSFRS-R) is used to monitor function and disease progression in individuals with amyotrophic lateral sclerosis (ALS). However, the performance of the self-administered ALSFRS-R has not been assessed using Rasch Measurement Theory. Therefore, the purpose of this study was to examine the psychometric properties of the self-administered ALSFRS-R using Rasch analysis. Methods Rasch analysis was performed on self-administered ALSFRS-R data from individuals with ALS across Canada. The following 6 aspects of Rasch analysis were examined using RUMM2030: fit via residuals and chi-square statistics, targeting via person-item threshold maps, dependency via item residual correlations, unidimensionality through principal components analysis of residuals, reliability via person separation index, and stability through differential item functioning analyses for sex, age, and language. Results Analysis was performed on 122 participants (mean age: 52.9 years; 62.8% men). The overall scale demonstrated good fit, reliability, and stability; however, multidimensionality was found. To address this issue, items were divided into 3 subscales (bulbar, motor, and respiratory function), and Rasch analysis was performed for each subscale. The subscales demonstrated good fit, reliability, stability, and unidimensionality. However, there were still issues with item dependency for all subscale and targeting for bulbar and respiratory subscales. Conclusions The self-administered ALSFRS-R is reliable, internally valid, and stable across sex, age, and language subgroups; however, it is recommended that the ALSFRS-R be scored by subscale. Future studies can look at revising and/or adding items to tackle misfit, redundancy, and ceiling effects. Impact Self-administered measures are simple to administer and inexpensive. The self-administered ALSFRS-R was found to be psychometrically sound and can be used as a tool to monitor disease progression and function in ALS. [ABSTRACT FROM AUTHOR]
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- 2023
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13. Assessing evidence to improve population health and wellbeing
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Aceijas, Carmen
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Evidence-based medicine -- Case studies ,Evidence-based medicine -- Methodology ,Public health -- Evaluation ,Public health -- Research -- Methodology ,Public Health ,Outcome Assessment (Health Care) - Abstract
Summary: Written to support practitioners undertaking a Masters in public health, this book considers the main concepts, issues and methodologies of the second core competence of the Public Health Skills and Career Framework: 'Assessment of evidence of the effectiveness of interventions, programmes and services to improve population health and wellbeing'. Coverage includes the theoretical definition of evidence and its use in public health, the role of critical appraisal methods and tools in evidence assessment and how Effectiveness, Efficiency and Quality inform evidence. The book is packed with case studies and activities to help link theory and practice and prompt personal reflection.
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- 2011
14. Cases on health outcomes and clinical data mining : studies and frameworks.
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Cerrito, Patricia B.
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Data mining ,Outcome assessment (Medical care) ,Outcome Assessment (Health Care) ,Data Mining -- methods ,Models, Statistical - Abstract
Summary: "Because so much data is now becoming readily available to investigate health outcomes, it is important to examine just how statistical models are used to do this. This book studies health outcomes research using data mining techniques"--Provided by publisher.
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- 2010
15. What outcomes do studies use to measure the impact of prognostication on people with advanced cancer? Findings from a systematic review of quantitative and qualitative studies.
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Spooner, Caitlin, Vivat, Bella, White, Nicola, Bruun, Andrea, Rohde, Gudrun, Kwek, Pei Xing, and Stone, Patrick
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PSYCHOLOGY information storage & retrieval systems , *CINAHL database , *MEDICAL databases , *CAREGIVER attitudes , *WELL-being , *HOSPICE care , *MEDICAL information storage & retrieval systems , *SPIRITUALITY , *SYSTEMATIC reviews , *METASTASIS , *HEALTH outcome assessment , *CANCER relapse , *COGNITION , *TREATMENT effectiveness , *PATIENTS' attitudes , *LIFE , *RESEARCH funding , *TUMORS , *MEDLINE , *PALLIATIVE treatment - Abstract
Background: Studies evaluating the impact of prognostication in advanced cancer patients vary in the outcomes they measure, and there is a lack of consensus about which outcomes are most important. Aim: To identify outcomes previously reported in prognostic research with people with advanced cancer, as a first step towards constructing a core outcome set for prognostic impact studies. Design: A systematic review was conducted and analysed in two subsets: one qualitative and one quantitative. (PROSPERO ID: CRD42022320117; 29/03/2022). Data sources: Six databases were searched from inception to September 2022. We extracted data describing (1) outcomes used to measure the impact of prognostication and (2) patients' and informal caregivers' experiences and perceptions of prognostication in advanced cancer. We classified findings using the Core Outcome Measures in Effectiveness Trials (COMET) initiative taxonomy, along with a narrative description. We appraised retrieved studies for quality, but quality was not a basis for exclusion. Results: We identified 42 eligible studies: 32 quantitative, 6 qualitative, 4 mixed methods. We extracted 70 outcomes of prognostication in advanced cancer and organised them into 12 domains: (1) survival; (2) psychiatric outcomes; (3) general outcomes; (4) spiritual/religious/existential functioning/wellbeing, (5) emotional functioning/wellbeing; (6) cognitive functioning; (7) social functioning; (8) global quality of life; (9) delivery of care; (10) perceived health status; (11) personal circumstances; and (12) hospital/hospice use. Conclusion: Outcome reporting and measurement varied markedly across the studies. A standardised approach to outcome reporting in studies of prognosis is necessary to enhance data synthesis, improve clinical practice and better align with stakeholders' priorities. [ABSTRACT FROM AUTHOR]
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- 2023
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16. Radiographic predictors of occult intracranial involvement in olfactory neuroblastoma patients.
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Geltzeiler, Mathew, Choby, Garret W., Ji, Keven Seung Yong, JessMace, C., Almeida, Joao Paulo, de Almeida, John, Champagne, Pierre‐Olivier, Chan, Erik, Ciporen, Jeremy N., Chaskes, Mark B., Cornell, Sarah, Drozdowski, Veronica, Fernandez‐Miranda, Juan, Gardner, Paul A., Hwang, Peter H., Kalyvas, Aristotelis, Kong, Keonho A., McMillan, Ryan A., Nayak, Jayakar V., and Patel, Chirag
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SKULL base , *OLFACTORY bulb , *CRIBRIFORM plate , *MAGNETIC resonance imaging , *OCCULTISM , *SMELL disorders , *NEUROBLASTOMA - Abstract
Background: Traditional management of olfactory neuroblastoma (ONB) includes margin‐negative resection with removal of cribriform plate, dura, and olfactory bulb, regardless of intracranial disease. This approach may be overtreating certain patients. Our investigation examines risk factors associated with occult intracranial disease to optimize therapeutic outcomes. Methods: This retrospective, multi‐institutional cohort study examined clinical covariates associated with occult intracranial involvement. Patient demographics, staging, Hyam's grade, and pathologic involvement of dura, olfactory bulb/tract, and brain were collected. Diagnostic imaging was reviewed. Positive and negative predictive value (NPV) were estimated along with effect size estimates. Cox hazard regression examined associations with overall survival (OS) and disease‐free survival (DFS). Results: A total of 224 subjects with new diagnoses of ONB (2005–2021) were identified. Skull base bone involvement on computed tomography (CT) had the highest NPV for pathologic dura (88.0%), olfactory bulb (88%), and brain involvement (97.3%). Hyam's grade category was significantly associated with dural involvement (φC = 0.26; 95% confidence interval [CI]: 0.16, 0.42). Subjects without radiologic skull base involvement (n = 66) had pathologic positivity of 12.1%. Within this subgroup, Hyam's grade was clinically significant for dural positivity (φ = 0.34; 95% CI: −0.12, 0.71) with 28.6% involvement in high grade tumors. Neither clinical nor pathologic positivity of intracranial structures were associated with significantly different OS or DFS. Conclusions: Both CT and magnetic resonance imaging (MRI) had reasonably good NPV for involvement of dura and olfactory bulb. Higher Hyam's grade was associated with dural involvement. Patients with low‐grade tumors not involving the skull base may be suitable for avoiding skull base resection; however, further investigation is warranted. [ABSTRACT FROM AUTHOR]
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- 2023
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17. Significant Clinical Improvement Was Predicted in a Cohort of Patients With Low Back Pain Early in the Care Process.
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Brennan, Gerard P, Snow, Greg, Minick, Kate I, and Stevans, Joel M
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LUMBAR pain , *PREDICTIVE tests , *SCIENTIFIC observation , *NURSING care plans , *PHYSICAL therapy , *RETROSPECTIVE studies , *QUESTIONNAIRES , *MEDICAL appointments , *PREDICTION models , *STATISTICAL models , *LOGISTIC regression analysis , *DECISION making in clinical medicine , *RECEIVER operating characteristic curves , *LONGITUDINAL method , *PAIN management - Abstract
Objective The purpose of this study was to determine the proportion of patients with low back pain who achieved clinical improvement in disability within 3 or 6 physical therapy visits, identify factors that predicted improvement, and predict the probability of improvement by the third and sixth visits. Methods This retrospective, observational study looked at patients (N = 6523) who completed a numeric pain scale and Modified Low Back Disability Questionnaire (MDQ) at every visit. Four prediction models were developed: 30% improvement by visit 3 and by visit 6 and 50% improvement by visit 3 and by visit 6. A logistic regression model was fit to predict patients' improvement in disability using the MDQ. Predictive models used age, disability scores, sex, symptom duration, and payer type as factors. Receiver operating characteristic curves and area under the curve were computed for the models. Nomograms illustrate the relative impacts of the predictor variables. Results Disability improved 30% in 42.7% of patients by visit 3 and 49% by visit 6. Disability improved 50% in 26% of patients by visit 3 and 32.9% by visit 6. First visit score (MDQ1) was strongest factor to predict 30% improvement by visit 3. The visit 3 score (MDQ3) was strongest factor to predict a 30% or 50% improvement by visit 6. The combination of MDQ1 and MDQ3 scores was strongest overall predictive factor for visit 6. The area under the curve values for models using only the MDQ1 and MDQ3 scores to predict 30% or 50% improvement by the sixth visit were 0.84 and 0.85, respectively, representing excellent overall diagnostic accuracy of the prediction models. Conclusion Excellent discrimination to predict patients' significant clinical improvement by visit 6 using 2 outcome scores was demonstrated. Gathering outcomes routinely enhances assessment of prognosis and clinical decision making. Impact Understanding prognosis of clinical improvement supports physical therapists' contribution to value-based care. [ABSTRACT FROM AUTHOR]
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- 2023
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18. Effect of sarcopenia on survival outcomes in patients with nasopharyngeal and sinonasal cancer.
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Kim, Jee‐Hong, Mualla, Rula, Mace, Jess C., Santucci, Nicole M., Hill, Matthew J., Pfeifer, Hailey, Olson, Brennan, Li, Ryan J., Colaianni, Alessandra, Andersen, Peter E., Smith, Timothy L., Clayburgh, Daniel R., and Geltzeiler, Mathew
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HEAD & neck cancer , *SARCOPENIA , *NASOPHARYNX cancer , *SURVIVAL rate , *OVERALL survival , *TREATMENT effectiveness - Abstract
Establishment and validation of pre-therapy cervical vertebrae muscle quantification as a prognostic marker of sarcopenia in patients with head and neck cancer. Keywords: neoplasms; outcome assessment (health care); sarcopenia; survival EN neoplasms outcome assessment (health care) sarcopenia survival 1554 1557 4 07/26/23 20230801 NES 230801 INTRODUCTION Sarcopenia is characterized by low skeletal muscle mass (SMM), combined with low physical performance, and serves as a measure of functional impairment, physical disability, and frailty.[1] Sarcopenia has been shown to be a significant negative predictor of long-term, overall survival (OS) in patients undergoing major head and neck cancer surgery.[[2]] Currently there is a lack of evidence that identifies sarcopenia as a significant predictor of mortality, specifically in sinonasal carcinoma (SNC) and nasopharyngeal carcinoma (NPC). [Extracted from the article]
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- 2023
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19. Inferior mesenteric artery revascularization can supplement salvage of mesenteric ischemia
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Zach M. Feldman, MD, MPH, MSc, Brandon J. Sumpio, MD, Young Kim, MD, MS, Christopher J. Kwolek, MD, MBA, Glenn M. LaMuraglia, MD, Mark F. Conrad, MD, MMSc, and Sunita D. Srivastava, MD
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Inferior ,Mesenteric artery ,Mesenteric ischemia ,Mesenteric vascular insufficiency ,Outcome assessment (health care) ,Thrombosis ,Surgery ,RD1-811 ,Diseases of the circulatory (Cardiovascular) system ,RC666-701 - Abstract
The inferior mesenteric artery (IMA) has often been overlooked in favor of the celiac or superior mesenteric artery in arterial mesenteric ischemia, owing to the typically robust visceral collateral networks. In the present report, we have described a case series of patients in whom “salvage” revascularization of the IMA was performed after attempted celiac or superior mesenteric artery revascularization had been unsuccessful. The restored IMA inflow had resolved the symptoms for three patients. However, sole IMA revascularization was insufficient to reverse the course for two other patients with severe acute-on-chronic mesenteric ischemia. The IMA should be considered for salvage revascularization in the appropriate clinical scenario.
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- 2023
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20. Relative contribution of acute cognitive and motor functioning on community integration 1 year after moderate-severe TBI.
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Swank, Chad, Esterov, Dmitry, Bennett, Monica, Hammond, Flora M., and Dams-O'Connor, Kristen
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INJURY risk factors , *INTERVIEWING , *SURGICAL complications , *FUNCTIONAL assessment , *RISK assessment , *INDEPENDENT living , *DESCRIPTIVE statistics , *RESEARCH funding , *EMPLOYMENT , *AUTOMOBILE driving , *REHABILITATION , *COGNITIVE testing , *ODDS ratio , *REHABILITATION for brain injury patients , *MOTOR ability , *SECONDARY analysis - Abstract
The objective of this study was to understand the relative contribution of acute motor versus cognitive functioning on community integration 1 year after moderate-severe traumatic brain injury (TBI). Secondary data analysis of 779 participants in the TBI Model Systems National Database who experienced a moderate-severe TBI requiring inpatient rehabilitation. Participants were categorized into four groups: low motor/low cognition, low motor/high cognition, high motor/low cognition, or high motor/high cognition. Community integration outcomes measured 1 year post-TBI included the Participation Assessment with Recombined Tools-Objective (PART-O), driving status, Supervision Rating Scale, residence, re-injury, and employment status. Participants with both high motor/high cognition had higher scores on the PART-O total score (p < 0.001), living independently (p = 0.023), living in a private residence (p = 0.002), and being employed (p = 0.026) at 1 year. Participants with high motor/high cognition and high motor/low cognition had higher odds of driving (p = 0.001 and p = 0.034, respectively) when compared to low motor/low cognition. All groups relative to the low motor/low cognition group had higher odds of being re-injured. High motor and high cognitive function at rehabilitation are associated with favorable community integration outcomes 1 year post-injury, though greater participation afforded by high function may confer elevated risk of re-injury. [ABSTRACT FROM AUTHOR]
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- 2023
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21. When 'good' is not good enough: a retrospective Rasch analysis study of the Berg Balance Scale for persons with Multiple Sclerosis.
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Caselli, Serena, Sabattini, Loredana, Cattaneo, Davide, Jonsdottir, Johanna, Brichetto, Giampaolo, Pozzi, Stefania, Lugaresi, Alessandra, and La Porta, Fabio
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MULTIPLE sclerosis ,PEOPLE with disabilities ,RETROSPECTIVE studies ,RASCH models ,PHYSICAL mobility ,REHABILITATION centers - Abstract
Background: The Berg Balance Scale (BBS) is one of the most used tools to quantify balance in Persons with Multiple Sclerosis, a population at high risk of falling. Aim: To evaluate the measurement characteristics of the BBS in Multiple Sclerosis through Rasch analysis. Design: Retrospective study. Setting: Outpatients in three Italian Rehabilitation centers. Population: Eight hundred and fourteen persons with Multiple Sclerosis able to stand independently for more than 3 s. Methods: The sample (N = 1,220) was split into one validating (B1) and three confirmatory subsamples. Following the Rasch analysis performed on B1, the item estimates were exported and anchored to the three confirmatory subsamples. After obtaining the same final solution across all samples, we studied the convergent and discriminant validity of the final BBS-MS using the EDSS, the ABC scale, and the number of falls. Results: The base analysis on the B1 subsample failed the monotonicity, local independence, and unidimensionality requirements and did not fit the Rasch model. After grouping locally dependent items, the BBS-MS fitted the model (X28 = 23.8; p = 0.003) and satisfied all requirements for adequate internal construct validity (ICV). However, it was mistargeted to the sample, given the striking prevalence of higher scores (targeting index 1.922) with a distribution-independent Person Separation Index sufficient for individual measurements (0.962). The B1 item estimates were anchored to the confirmatory samples with confirmation of adequate fit (X2 = [19.0, 22.8], value of ps = [0.015, 0.004]) and satisfaction of all ICV requirements for all subsamples. The final BBS-MS directly correlated with the ABC scale (rho = 0.523) and inversely with EDSS (rho = -0.573). The BBS-MS estimates significantly differed across groups according to the pre-specified hypotheses (between the three EDSS groups, between the ABC cut-offs, distinguishing 'fallers' vs. 'non-fallers', and between the 'low' vs. 'moderate' vs. 'high' levels of physical functioning; and, finally, between 'no falls' vs. 'one or more falls'). Conclusion: This study supports the internal construct validity and reliability of the BBS-MS in an Italian multicentre sample of persons with Multiple Sclerosis. However, as the scale is slightly mistargeted to the sample, it represents a candidate tool to assess balance, mainly in more disabled people with an advanced walking disability. [ABSTRACT FROM AUTHOR]
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- 2023
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22. Dental Health Services Victoria value‐based health care principles for oral health models of care.
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Lin, Clare Elizabeth, Nguyen, Tan Minh, McGrath, Roisin, Patterson, Amy, and Hall, Martin
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DENTAL care ,VALUE-based healthcare ,DENTAL auxiliary personnel ,HEALTH care reform ,MEDICAL care ,ORAL health - Abstract
Background: Efforts to progress oral healthcare reform can be challenging with competing interests of governments and service providers to achieve the intended outcomes. The value‐based health care approach has been adopted in many areas of healthcare but has had limited applications to oral healthcare systems. Dental Health Services Victoria, an Australian state government funded entity, commenced its journey to value‐based health care in 2016, to shift away from traditional dental service models that reward activity and volume towards a stronger emphasis on value and outcomes. Aims: To maintain the value‐based health care agenda focus, Dental Health Services Victoria developed three key principles, which can be adopted by other organisations engaged in reforming oral healthcare, to improve the oral health for the population it serves. Materials & Methods: In 2018, Dental Health Services Victoria developed a value‐based health care framework, which has informed strategic organisation priorities for action. In 2023, the following three key principles are identified as being essential to support the operationalisation and development of effective models of oral healthcare: Principle 1 – Care is co‐designed with the person or population Principle 2 – Prevention and early intervention are prioritised. Principle 3 – Consistent measurement of health outcomes and costs are embedded. Discussion: The exploration of the three key principles is an important communication tool to translate value‐based health care into practice with key stakeholders. Further work is required to socialise them to within dental teams. Conclusion: Organisations looking to commence the value‐based health care agenda can apply Dental Health Services Victoria's three key principles as a first step. [ABSTRACT FROM AUTHOR]
- Published
- 2023
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23. The clinical aspects ot the sulphonylurea compounds from the position of the cardioprotective approach at patient with type 2 diabetes, using glucocardiomonitoring
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N. A. Chernikova, L. L. Kamynina, A. S. Аmetov, and D. A. Sychov
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type 2 diabetes mellitus ,cardiovascular diseases ,outcome assessment (health care) ,sulfonylurea compounds ,glyburide ,gliсlazide ,continuous glucose monitoring ,time in range ,electrocardiography ,ambulatory ,Nutritional diseases. Deficiency diseases ,RC620-627 - Abstract
BACKGRAUND: Now the trend of Type 2 Diabetes Mellitus (T2DM) management from glucocentric to cardioprotective approach take place, and it especially relevant for the multiple group of patients with T2DM using Sulphonylurea (SU). Meanwhile the synchronized glucocardiomonitoring allowed to providing the accurate information about the cardiometabolic status of patients with T2DM.AIMS: Using the professional glucocardiomonitoring for T2DM-SU patients to investigate the relation between the glycemic variability, integral glycemic parameters and proarrhythmogenic cardiovascular events and the long-term cardiovascular outcomes.MATERIALS AND METHODS: In the observational (randomised for inclusion of patients) controlled trial the SU-patients with the T2DM duration 9,8±6,6 years were included, whom the professional glucocardiomonitoring had been made during 5 days and then the fatal and non-fatal cardiovascular events had been investigated during 5 years. RESULTS: From 283 patients with T2DM 154 patients (the basic group) used gliclazide (original drug Diabeton MB), 129 patients (the control group) used glibenclamide. The relation between the rising of the glycemic variability and cardiovascular events (the prolongation QT interval, the ST depression (dST), ventricular arrhythmias (VAs)) were demonstrated. At the basic and the control groups the coefficient of variation (CV) was 23,0±8,1 and 30,1±10,7% respectively (p 4 mmol/L/hr — 2,3±3,6 and 3,5±4,3 (p=0,010), the minimal glycemia level — 4,6±1,0 and 3,9±1,4 mmol/L (p=0,001). The followed differences of cardiovascular parameters were determined: QTc — 412±24 and 423±28 ms (p=0,001), dST — 0,052 [0; 0,275] and 0,109 [0; 0,422] (ratio, p=0,012), VAs — 2,2 [0; 5,9] and 3,5 [0; 8,3] (cases/pts, p=0,008). The long-term cardiovascular outcomes from the gliclazide and glibenclamide therapy (cases/100 pts-years): the total and cardiovascular death — 0,12 [0; 1,74] and 0,76 [0; 4,62] (p=0,062), cardiovascular death -0,12 [0; 1,74] and 0,62 [0; 4,08] (p=0,122), myocardial infarction — 1,56 [0; 6,94] and 2,00 [0; 8,02] (p=0,193), stroke — 0,78 [0; 4,66] and 0,76 [0; 4,62] (p=0,169), chronic heart failure — 0,52 [0; 3,72] and 1,24 [0; 6,06] (p=0,095), MACE — 2,46 [0; 10,1] и 2,62 [0; 9,38] (p=0,095), severe hypoglycemia at home — 2,46 [0; 9,12] и 7,24 [0; 16,68] (p
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- 2022
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24. Content and Clinical Validation of the Nursing Outcome "Health Literacy Behaviour": A Validation Protocol.
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Correro-Bermejo, Alba, Fernández-Gutiérrez, Martina, Poza-Méndez, Miriam, and Bas-Sarmiento, Pilar
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EVALUATION of medical care ,NURSING ,NOSOLOGY ,HEALTH literacy - Abstract
Health literacy (HL) is a result of health promotion and education that has been included as a nursing intervention since 2013. It was proposed, as a nursing activity, to "determine health literacy status at initiation of contact with the patient through informal and/or formal assessments". Because of that, the outcome 'Health Literacy Behaviour' has been incorporated in the sixth edition of the Nursing Outcomes Classification (NOC). It collects the patient's different HL levels and allows them to be identified and evaluated in a social and health context. Nursing outcomes are helpful and provide relevant information for the evaluation of nursing interventions. Objectives: To validate the contents of the nursing outcome 'Health Literacy Behaviour (2015)' in order to use them in nursing care plans, and to evaluate their psychometric properties, application level, and effectiveness in nursing care to detect low health literacy patients. Methods: a methodological two-phased study: (1) an exploratory study and content validation by expert consensus, who will evaluate revised content of nursing outcomes; (2) methodological design by clinical validation. Conclusion: The validation of this nursing outcome in NOC will enable the generation of a helpful tool that would facilitate nurses to set individualised and efficient care interventions and identify low health literacy populations. [ABSTRACT FROM AUTHOR]
- Published
- 2023
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25. A comparative analysis of endoscopic sinus surgery versus biologics for treatment of chronic rhinosinusitis with nasal polyposis.
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Miglani, Amar, Soler, Zachary M., Smith, Timothy L., Mace, Jess C, and Schlosser, Rodney J.
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ENDOSCOPIC surgery , *NASAL polyps , *DUPILUMAB , *SINUSITIS , *BIOTHERAPY , *OMALIZUMAB - Abstract
Background: Comparative effectiveness research between endoscopic sinus surgery (ESS) and biologic therapy for severe chronic rhinosinusitis with nasal polyposis (CRSwNP) is a nascent field as new therapeutic modalities become clinically available. Methods: A prospective, multicenter cohort of CRSwNP patients, undergoing ESS between 2011 and 2019, were compared to phase‐3 biologic trial data. Patients undergoing ESS received baseline nasal endoscopy quantified via Lund‐Kennedy (LK) grading. Patients meeting inclusion criteria, modified from Dupilumab‐LIBERTY‐NP‐24&52, omalizumab‐POLYP‐1&2, and Mepolizumab‐SYNAPSE clinical trials, were included in this study. Baseline characteristics and outcome measures were compared between these cohorts at 24 weeks and 52 weeks, when possible. Results: A total of 111 CRSwNP patients met modified inclusion criteria. There were no statistically significant differences in baseline age, sex, asthma status, aspirin‐exacerbated respiratory disease status, smell identification, LK‐polyp score, and Lund‐Mackay computed tomography (CT) scores between ESS and biologic groups. At 24 weeks, ESS demonstrated significantly greater improvements in 22‐item Sino‐Nasal Outcome Test (SNOT‐22) compared to one (of two) dupilumab trials (p < 0.05) and both omalizumab trials (p < 0.001). ESS associated with significantly lower nasal polyp scores (NPS) compared to dupilumab (p < 0.001) and omalizumab (p < 0.001), despite comparable improvements in smell identification (p > 0.05). At 52 weeks, ESS resulted in statistically similar improvement in SNOT‐22 scores compared to dupilumab (p = 0.21), but NPS remained significantly lower in the ESS group compared to dupilumab (p < 0.001) and mepolizumab (p < 0.001). Conclusion: At 24 weeks and 52 weeks, ESS offers comparable SNOT‐22 improvements compared to dupilumab. ESS and dupilumab offer comparable improvement in smell identification at 24 weeks. Compared to omalizumab, ESS offers superior SNOT‐22 improvements. ESS offers significantly greater reductions in polyp size compared to omalizumab, dupilumab, and mepolizumab therapies. [ABSTRACT FROM AUTHOR]
- Published
- 2023
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- View/download PDF
26. When ‘good’ is not good enough: a retrospective Rasch analysis study of the Berg Balance Scale for persons with Multiple Sclerosis
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Serena Caselli, Loredana Sabattini, Davide Cattaneo, Johanna Jonsdottir, Giampaolo Brichetto, Stefania Pozzi, Alessandra Lugaresi, and Fabio La Porta
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Multiple Sclerosis ,postural balance [MeSH] ,neurological rehabilitation (MeSH) ,outcome assessment (health care) ,psychometrics ,Neurology. Diseases of the nervous system ,RC346-429 - Abstract
BackgroundThe Berg Balance Scale (BBS) is one of the most used tools to quantify balance in Persons with Multiple Sclerosis, a population at high risk of falling.AimTo evaluate the measurement characteristics of the BBS in Multiple Sclerosis through Rasch analysis.DesignRetrospective study.SettingOutpatients in three Italian Rehabilitation centers.PopulationEight hundred and fourteen persons with Multiple Sclerosis able to stand independently for more than 3 s.MethodsThe sample (N = 1,220) was split into one validating (B1) and three confirmatory subsamples. Following the Rasch analysis performed on B1, the item estimates were exported and anchored to the three confirmatory subsamples. After obtaining the same final solution across all samples, we studied the convergent and discriminant validity of the final BBS-MS using the EDSS, the ABC scale, and the number of falls.ResultsThe base analysis on the B1 subsample failed the monotonicity, local independence, and unidimensionality requirements and did not fit the Rasch model. After grouping locally dependent items, the BBS-MS fitted the model (χ28 = 23.8; p = 0.003) and satisfied all requirements for adequate internal construct validity (ICV). However, it was mistargeted to the sample, given the striking prevalence of higher scores (targeting index 1.922) with a distribution-independent Person Separation Index sufficient for individual measurements (0.962). The B1 item estimates were anchored to the confirmatory samples with confirmation of adequate fit (χ2 = [19.0, 22.8], value of ps = [0.015, 0.004]) and satisfaction of all ICV requirements for all subsamples. The final BBS-MS directly correlated with the ABC scale (rho = 0.523) and inversely with EDSS (rho = −0.573). The BBS-MS estimates significantly differed across groups according to the pre-specified hypotheses (between the three EDSS groups, between the ABC cut-offs, distinguishing ‘fallers’ vs. ‘non-fallers’, and between the ‘low’ vs. ‘moderate’ vs. ‘high’ levels of physical functioning; and, finally, between ‘no falls’ vs. ‘one or more falls’).ConclusionThis study supports the internal construct validity and reliability of the BBS-MS in an Italian multicentre sample of persons with Multiple Sclerosis. However, as the scale is slightly mistargeted to the sample, it represents a candidate tool to assess balance, mainly in more disabled people with an advanced walking disability.
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- 2023
- Full Text
- View/download PDF
27. Effect and Associated Factors of the Clinical Pharmacy Model in the Incidence of Medical Errors (EACPharModel)
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Hospital Pablo Tobón Uribe
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- 2020
28. Real-time demonstration of a mHealth app designed to reduce college students hazardous drinking.
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Kazemi, Donna M, Borsari, Brian, Levine, Maureen J, Shehab, Mohamed, Nelson, Monica, Dooley, Beau, Stinson, Betria, Fang, Fang, and Li, Shaoyu
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Humans ,Alcoholism ,Focus Groups ,Telemedicine ,Students ,Adult ,Outcome Assessment (Health Care) ,Patient Acceptance of Health Care ,Female ,Male ,Young Adult ,Motivational Interviewing ,Mobile Applications ,Alcohol Drinking in College ,Ecological Momentary Assessment ,Outcome Assessment ,Health Care ,SmarTrek ,mHealth ,alcohol misuse ,motivational interviewing ,ecological momentary intervention ,Psychiatry ,Psychology - Abstract
Heavy alcohol use is a serious health issue in the United States with consequences such as illness, injury, and death. College students are among the most vulnerable to problems associated with risky drinking. This demographic is known as the Net Generation because members have grown up with digital technologies such as smartphones and apps. Thus, mobile health (mHealth) applications, successful in the delivery of health information and interventions to tech-savvy individuals, are a promising means of reaching them. To that end, we developed a smartphone application (SmarTrek) that targets college students and aims to reduce risky alcohol use. SmarTrek features are easy to use and have interactive components including text messages that incorporate motivational interviewing and ecological momentary interventions. We conducted iterative theater testing, field testing, and focus groups to evaluate the acceptability of SmarTrek with college students. We identified salient issues that might arise from SmarTrek use and modified the app based on feedback from participants. Participants were assigned to 2 groups (Group 1 [n = 4] and Group 2 [n = 6]). At baseline, participants completed 2 standardized surveys. Following their field testing, each group of participants was then invited to a focus group session of the app in which they provided feedback. The majority of participants (90%) agreed that SmarTrek was easy to use and that the information provided was useful and had a positive effect on decreasing their drinking. (PsycINFO Database Record (c) 2019 APA, all rights reserved).
- Published
- 2019
29. Long-Term Survivorship Care After Cancer Treatment - Summary of a 2017 National Cancer Policy Forum Workshop.
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Kline, Ronald M, Arora, Neeraj K, Bradley, Cathy J, Brauer, Eden R, Graves, Darci L, Lunsford, Natasha Buchanan, McCabe, Mary S, Nasso, Shelley Fuld, Nekhlyudov, Larissa, Rowland, Julia H, Schear, Rebekkah M, and Ganz, Patricia A
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Humans ,Neoplasms ,Risk Factors ,Mental Health ,Socioeconomic Factors ,Outcome Assessment (Health Care) ,Quality Improvement ,Cancer Survivors ,Survivorship ,Outcome Assessment ,Health Care ,Oncology and Carcinogenesis ,Oncology & Carcinogenesis - Abstract
The National Cancer Policy Forum of the National Academies of Sciences, Engineering and Medicine sponsored a workshop on July 24 and 25, 2017 on Long-Term Survivorship after Cancer Treatment. The workshop brought together diverse stakeholders (patients, advocates, academicians, clinicians, research funders, and policymakers) to review progress and ongoing challenges since the Institute of Medicine (IOM)'s seminal report on the subject of adult cancer survivors published in 2006. This commentary profiles the content of the meeting sessions and concludes with recommendations that stem from the workshop discussions. Although there has been progress over the past decade, many of the recommendations from the 2006 report have not been fully implemented. Obstacles related to the routine delivery of standardized physical and psychosocial care services to cancer survivors are substantial, with important gaps in care for patients and caregivers. Innovative care models for cancer survivors have emerged, and changes in accreditation requirements such as the Commission on Cancer's (CoC) requirement for survivorship care planning have put cancer survivorship on the radar. The Center for Medicare & Medicaid Innovation's Oncology Care Model (OCM), which requires psychosocial services and the creation of survivorship care plans for its beneficiary participants, has placed increased emphasis on this service. The OCM, in conjunction with the CoC requirement, is encouraging electronic health record vendors to incorporate survivorship care planning functionality into updated versions of their products. As new models of care emerge, coordination and communication among survivors and their clinicians will be required to implement patient- and community-centered strategies.
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- 2018
30. Considerations from the 2017 IMFAR Preconference on Measuring Meaningful Outcomes from School-Age to Adulthood.
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Bal, Vanessa H, Hendren, Robert L, Charman, Tony, Abbeduto, Leonard, Kasari, Connie, Klinger, Laura Grofer, Ence, Whitney, Glavin, Tara, Lyons, Gregory, and Rosenberg, Erin
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Humans ,Research ,Internationality ,Adolescent ,Adult ,Child ,Societies ,Medical ,Outcome Assessment (Health Care) ,Female ,Male ,Young Adult ,Autism Spectrum Disorder ,lifespan ,outcome ,stakeholders ,strengths ,Outcome Assessment ,Health Care ,Autism ,Pediatric ,Intellectual and Developmental Disabilities (IDD) ,Brain Disorders ,Mental Health ,Clinical Research ,Societies ,Medical ,Outcome Assessment ,Health Care ,Developmental & Child Psychology ,Clinical Sciences ,Neurosciences ,Psychology - Abstract
The autism spectrum disorder (ASD) research community is increasingly considering the importance of measuring outcomes that are meaningful to individuals with ASD and their families. The 2017 IMFAR preconference aimed to gain the perspectives of how to define and measure "meaningful outcomes" from 280 participants, including people with ASD and their families, service providers, and researchers. Six themes were identified: (a) the definition of "outcome" varies by context and perspective; (b) the need to broaden the scope of what researchers measure; (c) the need for new assessment tools; (d) the need to expand data analytic methods; (e) where to focus (with emphasis on considering different developmental stages and aspects of diversity); and (f) a need for community partnerships to bridge research and daily practice. The challenge that the research community now faces is how to move the evidence base for clinical practice forward while keeping alive the divergence of views and considerations that are relevant for thinking about complex outcomes for the highly heterogeneous group of individuals with ASD. This commentary provides recommendations, with an emphasis on lifespan viewpoints that encompass individual strengths and preferences. Autism Research 2018, 11: 1446-1454. © 2018 International Society for Autism Research, Wiley Periodicals, Inc. LAY SUMMARY: The 2017 IMFAR preconference aimed to gain the perspectives of how to define and measure "meaningful outcomes" from a variety of stakeholders. This commentary outlines the six themes identified from keynote and panel presentations and audience-participated discussions. Recommendations are made to emphasize perspectives that look across the lifespan and encompass individual strengths and preferences.
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- 2018
31. Measurement of Mobility and Physical Function in Patients Hospitalized With Hip Fracture: A Systematic Review of Instruments and Their Measurement Properties.
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Rix, Alana, Lawrence, Drew, Raper, Eleanor, Calthorpe, Sara, Holland, Anne E, and Kimmel, Lara A
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CINAHL database , *PREDICTIVE tests , *MEDICAL information storage & retrieval systems , *SYSTEMATIC reviews , *HIP fractures , *HEALTH outcome assessment , *HOSPITAL care , *PHYSICAL mobility , *DESCRIPTIVE statistics , *MEDLINE ,RESEARCH evaluation - Abstract
Objective Hip fractures are common and significantly impact mobility and physical function. Measurement of patient progress post hip fracture in the acute hospital setting is important to monitor early recovery and outcomes. The objective of this systematic review was to assess the measurement properties (reliability, validity, responsiveness), interpretability, and clinical utility of instruments used to measure mobility and physical function in patients with hip fracture in the acute hospital setting. Methods Three databases (MEDLINE, Embase, and CINAHL) were searched. Studies reporting direct clinician assessment instruments to measure mobility or physical function in patients with hip fracture were included. Data were extracted by 2 reviewers, and the quality of each study was determined using the COnsensus-based Standards for the selection of health Measurement INstruments risk of bias checklist. Results Sixty-eight studies were included with 19 measurement instruments identified. The most frequently used instruments were the Timed "Up & Go" Test (TUG) (19 studies), Barthel Index (BI) (18 studies), Cumulated Ambulation Score (CAS) (18 studies), and Functional Independence Measure (FIM) (14 studies). All 4 of these instruments demonstrated good predictive validity (clinical outcomes and mortality) and responsiveness over time (effect sizes 0.63–2.79). The BI and CAS also had good reliability (intraclass correlation coefficient [ICC] >0.70). Floor effects were demonstrated for the TUG, CAS, and FIM (16%–60% of patients). The TUG, CAS, and BI all had good clinical utility. Conclusion Depending on the context (use by treating clinicians, research, benchmarking), 1 or a combination of the BI, CAS, and TUG provide robust measurement of mobility and physical function for patients with hip fracture in the acute hospital setting. Impact This study identified 3 instruments suitable for measuring mobility and physical function in hospitalized patients following hip fracture. This provides clinicians with tools to measure patient progress and benchmark across sites to improve patient outcomes. [ABSTRACT FROM AUTHOR]
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- 2023
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32. Partial and complete explantation of aortic endografts in the modern era.
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Feldman, Zach M., Kim, Daniel, Roddy, Connor, Sumpio, Brandon J., DeCarlo, Charles S., Kwolek, Christopher J., LaMuraglia, Glenn M., Eagleton, Matthew J., Mohebali, Jahan, and Srivastava, Sunita D.
- Abstract
Despite the progressive advancement of devices for endovascular aortic repair (EVAR), endografts continue to fail, requiring explant. We present a single-institutional experience of EVAR explants, characterizing modern failure modes, presentation, and outcomes for partial and complete EVAR explantation. A retrospective analysis was performed of all EVARs explanted at an urban quaternary center from 2001 to 2020, with one infected endograft excluded. Patient and graft characteristics, indications, and perioperative and long-term outcomes were analyzed. Partial versus complete explants were performed per surgeon discretion without a predefined protocol. This process was informed by patient risk factors; asymptomatic, symptomatic, or ruptured aneurysm presentation; and anatomical or intraoperative factors, including endoleak type. From 2001 to 2020, 52 explants met the inclusion and exclusion criteria. More than one-half (57.7%) were explants of EVAR devices placed at outside institutions, designated nonindex explants. Most patients were male (86.5%), the median age was 74 years (interquartile range, 70-78 years). More than one-half (61.5%) were performed in the second decade of the study period. The most commonly explanted grafts were Gore Excluder (n = 9 grafts), Cook Zenith (n = 8), Endologix AFX (n = 7), Medtronic Endurant (n = 5), and Medtronic Talent (n = 5). Most grafts (78.8%) were explanted for neck degeneration or sac expansion. Five were explanted for initial seal failure, five for symptomatic expansion, and seven for rupture. The median implant duration was 4.2 years, although ranging widely (interquartile range, 2.6-5.1 years), but similar between index and nonindex explants (4.2 years vs 4.1 years). Partial explantation was performed in 61.5%, with implant duration slightly lower, 3.2 years versus 4.4 years for complete explants. Partial explantation was more frequent in index explants (68.2% vs 56.7%). The median length of stay was 8 days. The median intensive care unit length of stay was 3 days, without significant differences in nonindex explants (4 days vs 3 days) and partial explants (4 days vs 3 days). Thirty-day mortality occurred in two nonindex explants (one partial and one complete explant). Thirty-day readmission was similar between partial and complete explants (9.7% vs 5.0%), without accounting for nonindex readmissions. Long-term survival was comparable between partial and complete explants in Cox regression (hazard ratio, 2.45; 95% confidence interval, 0.79-7.56; P =.12). Explants of EVAR devices have increased over time at our institution. Partial explant was performed in more than one-half of cases, per operating surgeon discretion, demonstrating higher blood loss, more frequent acute kidney injury, and longer intensive care unit stays, however with comparable short-term mortality and long-term survival. [ABSTRACT FROM AUTHOR]
- Published
- 2023
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33. Clinical Properties of the 6-Clicks and Functional Status Score for the ICU in a Hospital in the United Arab Emirates.
- Author
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Thrush, Aaron and Steenbergen, Emma
- Abstract
• Both instruments are responsive to measure mobility among hospitalized adults. • The Activity Measure for Post-Acute Care Inpatient Mobility Short Form has more disadvantageous floor and ceiling effects. • Minimal detectable change for the Activity Measure for Post-Acute Care Inpatient Mobility Short Form is 4.3 and for the Functional Status Score for the Intensive Care Unit is 3.9. To determine measurement properties of the Activity Measure for Post-Acute Care Inpatient Mobility Short Form (6-clicks) and Functional Status Score for the Intensive Care Unit (FSS-ICU). Retrospective analysis of scores from a cohort of patients over 24 months. Outcome measures were administered to patients referred to physical therapy on admission and discharge. Tertiary care hospital in the United Arab Emirates. 2793 adults referred to physical therapy; 62% were male, with a median age of 58 (interquartile range=44-70) and the median length of stay was 14 days (interquartile range=8-28). Not applicable. Instruments' clinical measurement properties: (1) responsiveness as per mean change and effect size; (2) floor and ceiling effects; and (3) minimal important difference. Results were analyzed for the whole group as well as 3 subgroups: patients with stroke as primary diagnosis (n = 644), discharged from heart and vascular floors (n = 642), and discharged from medical floors (n = 554). The mean change and effect size (Cohen's d) for the 6-clicks were +8.3 (±8.6) and 0.97, and for the FSS-ICU they were +6.8 (±7.8) and 0.87, respectively. 6-Clicks had a floor effect on admission among patients with stroke (16.9%) and patients discharged from medical floors (19.3%), as well as a ceiling effect on discharge (25.5% in the whole group). The FSS-ICU had a ceiling effect on discharge (23.2% in whole group). The estimated minimal important difference for the 6-clicks was 4.3, and for the FSS-ICU it was 3.9. Both instruments demonstrate good responsiveness in adults hospitalized in the United Arab Emirates. The FSS-ICU exhibited several advantages in performance that suggest greater clinical utility than the 6-clicks. Minimal important differences were generated, which has not been previously reported for the 6-clicks. [ABSTRACT FROM AUTHOR]
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- 2022
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34. Prioritizing outcome measures after aneurysmal subarachnoid hemorrhage: A q-sort survey of patients, health care providers and researchers.
- Author
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Andersen, Christopher R., Presseau, Justin, Saigle, Victoria, Fitzgerald, Emily, Lamanna, Madeline, Talbot, Phil, Delaney, Anthony, and English, Shane W.
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MEDICAL personnel ,SUBARACHNOID hemorrhage ,PATIENT surveys ,PRINCIPAL components analysis - Abstract
Objective: To understand which outcomemeasures patients and their families, health care providers, and researchers prioritize after aneurysmal subarachnoid hemorrhage (aSAH). Methods: We conducted a cross-sectional q-sort survey with participants from three key stakeholder groups. Potential outcomes were identified from interviews and focus groups. Participants were purposively sampled to achieve diversity based on stakeholder group, geography, and profession. Respondents sorted 27 outcomes in a quasi-normally distributed grid (Q-Sort) from most to least important. Principal components analysis was used to determine similarities in the way participants sorted the outcome measures resulting in distinct groupings. Overall rankings were also reported. Results: 112 participants were invited. 70 responded and 64 participants from 25 different countries completed a Q-sort. Balanced stakeholder representation was achieved. Five distinct patterns were identified based on survival, pathophysiological, psychological, resource use, and functional outcome measures. Quality of life as reported by the patient was the highest ranked outcomemeasure followed by independence and functionalmeasures. Survival and biomedical outcomes were ranked in the middle and cost measures last. Conclusions: In this diverse sample of key stakeholders, we characterized several distinct perspectives with respect to outcome measure selection in aSAH.We did not identify a clear pattern of opinion based on stakeholder group or other participant characteristics. Patient-reported measure of quality of life was ranked the most important overall with function and independence also highly rated. These results will assist study design and informeorts to improve outcome selection in aSAH research. [ABSTRACT FROM AUTHOR]
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- 2022
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35. Evaluation of Effectiveness of a Community-Based Intervention for Control of Dengue Virus Vector, Ouagadougou, Burkina Faso.
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Ouédraogo, Samiratou, Benmarhnia, Tarik, Bonnet, Emmanuel, Somé, Paul-André, Barro, Ahmed S, Kafando, Yamba, Soma, Diloma Dieudonné, Dabiré, Roch K, Saré, Diane, Fournet, Florence, and Ridde, Valéry
- Subjects
Animals ,Humans ,Dengue Virus ,Dengue ,Epidemiologic Research Design ,Disease Vectors ,Mosquito Control ,Geography ,Community Health Services ,Preventive Health Services ,Outcome Assessment (Health Care) ,Burkina Faso ,Mosquito Vectors ,Aedes aegypti ,arbovirus ,community-based ,dengue ,effectiveness ,intervention ,mosquitoes ,sub-Saharan Africa ,vector-borne disease ,viruses ,Outcome Assessment ,Health Care ,Outcome Assessment ,Health Care ,Microbiology ,Clinical Sciences ,Medical Microbiology ,Public Health and Health Services - Abstract
We evaluated the effectiveness of a community-based intervention for dengue vector control in Ouagadougou, the capital city of Burkina Faso. Households in the intervention (n = 287) and control (n = 289) neighborhoods were randomly sampled and the outcomes collected before the intervention (October 2015) and after the intervention (October 2016). The intervention reduced residents' exposure to dengue vector bites (vector saliva biomarker difference -0.08 [95% CI -0.11 to -0.04]). The pupae index declined in the intervention neighborhood (from 162.14 to 99.03) and increased in the control neighborhood (from 218.72 to 255.67). Residents in the intervention neighborhood were less likely to associate dengue with malaria (risk ratio 0.70 [95% CI 0.58-0.84]) and had increased knowledge about dengue symptoms (risk ratio 1.44 [95% CI 1.22-1.69]). Our study showed that well-planned, evidence/community-based interventions that control exposure to dengue vectors are feasible and effective in urban settings in Africa that have limited resources.
- Published
- 2018
36. Engagement in PCORnet Research Networks.
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Kim, Katherine K and Helfand, Mark
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Humans ,Evidence-Based Medicine ,Patient Selection ,Quality of Life ,Patient Participation ,Patient-Centered Care ,Outcome Assessment (Health Care) ,United States ,Comparative Effectiveness Research ,Outcome Assessment ,Health Care ,Outcome Assessment ,Health Care ,Public Health And Health Services ,Applied Economics ,Health Policy & Services ,Public Health and Health Services - Published
- 2018
37. The Cost of Caring: Economic Vulnerability, Serious Emotional Distress, and Poor Health Behaviors Among Paid and Unpaid Family and Friend Caregivers.
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Hoffman, Geoffrey J and Wallace, Steven P
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Humans ,Health Surveys ,Stress ,Psychological ,Health Behavior ,Family ,Aged ,Middle Aged ,Caregivers ,Friends ,Salaries and Fringe Benefits ,Home Care Agencies ,Outcome Assessment (Health Care) ,United States ,California ,Female ,Male ,Interviews as Topic ,Economic Status ,Medicaid ,caregiving formal ,consumer-driven programs ,distress ,health behavior ,Gerontology ,Clinical Sciences ,Cognitive Sciences - Abstract
This study examined differences between paid and unpaid family/friend caregivers to better understand the consumer-driven caregiving workforce. We compared economic vulnerability, unhealthy behavior, and serious emotional distress for 475 paid and 10,500 unpaid family/friend informal caregivers from the 2009 California Health Interview Survey. We then estimated whether caregiver status moderated the relationship between economic vulnerability and health outcomes. Compared to unpaid family/friend caregivers, paid family/friend caregivers had a 27% greater risk ( p = .002) of economic vulnerability. Among all family/friend caregivers, the probabilities of serious emotional distress and unhealthy behaviors increased by >100% and 28% for those with the greatest compared to the least economic vulnerability, and caregiver type did not moderate these relationships. To address economic and health vulnerabilities of paid informal caregivers, policy makers might increase wages in consumer-driven programs. These changes could prove beneficial to both paid informal caregivers and their care recipients, while reducing long-term inefficiencies in consumer-driven programs.
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- 2018
38. Radiomics for Response and Outcome Assessment for Non-Small Cell Lung Cancer.
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Shi, Liting, He, Yaoyao, Yuan, Zilong, Benedict, Stanley, Valicenti, Richard, Qiu, Jianfeng, and Rong, Yi
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Humans ,Carcinoma ,Non-Small-Cell Lung ,Lung Neoplasms ,Image Interpretation ,Computer-Assisted ,Diagnostic Imaging ,Radiation Oncology ,Outcome Assessment (Health Care) ,Data Mining ,Precision Medicine ,NSCLC ,chemotherapy ,radiomics ,radiotherapy ,response assessment ,systemic therapy ,Outcome Assessment ,Health Care ,Carcinoma ,Non-Small-Cell Lung ,Image Interpretation ,Computer-Assisted ,Outcome Assessment ,Health Care ,Oncology and Carcinogenesis ,Oncology & Carcinogenesis - Abstract
Routine follow-up visits and radiographic imaging are required for outcome evaluation and tumor recurrence monitoring. Yet more personalized surveillance is required in order to sufficiently address the nature of heterogeneity in nonsmall cell lung cancer and possible recurrences upon completion of treatment. Radiomics, an emerging noninvasive technology using medical imaging analysis and data mining methodology, has been adopted to the area of cancer diagnostics in recent years. Its potential application in response assessment for cancer treatment has also drawn considerable attention. Radiomics seeks to extract a large amount of valuable information from patients' medical images (both pretreatment and follow-up images) and quantitatively correlate image features with diagnostic and therapeutic outcomes. Radiomics relies on computers to identify and analyze vast amounts of quantitative image features that were previously overlooked, unmanageable, or failed to be identified (and recorded) by human eyes. The research area has been focusing on the predictive accuracy of pretreatment features for outcome and response and the early discovery of signs of tumor response, recurrence, distant metastasis, radiation-induced lung injury, death, and other outcomes, respectively. This review summarized the application of radiomics in response assessments in radiotherapy and chemotherapy for non-small cell lung cancer, including image acquisition/reconstruction, region of interest definition/segmentation, feature extraction, and feature selection and classification. The literature search for references of this article includes PubMed peer-reviewed publications over the last 10 years on the topics of radiomics, textural features, radiotherapy, chemotherapy, lung cancer, and response assessment. Summary tables of radiomics in response assessment and treatment outcome prediction in radiation oncology have been developed based on the comprehensive review of the literature.
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- 2018
39. Improving risk prediction model quality in the critically ill: data linkage study
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Paloma Ferrando-Vivas, Manu Shankar-Hari, Karen Thomas, James C Doidge, Fergus J Caskey, Lui Forni, Steve Harris, Marlies Ostermann, Ivan Gornik, Naomi Holman, Nazir Lone, Bob Young, David Jenkins, Stephen Webb, Jerry P Nolan, Jasmeet Soar, Kathryn M Rowan, and David A Harrison
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cardiopulmonary resuscitation ,critical care ,heart arrest ,hospital mortality ,intensive care ,models, statistical ,outcome assessment (health care) ,prognosis ,risk adjustment ,routine data ,Medicine (General) ,R5-920 ,Public aspects of medicine ,RA1-1270 - Abstract
Background: A previous National Institute for Health and Care Research study [Harrison DA, Ferrando-Vivas P, Shahin J, Rowan KM. Ensuring comparisons of health-care providers are fair: development and validation of risk prediction models for critically ill patients. Health Serv Deliv Res 2015;3(41)] identified the need for more research to understand risk factors and consequences of critical care and subsequent outcomes. Objectives: First, to improve risk models for adult general critical care by developing models for mortality at fixed time points and time-to-event outcomes, end-stage renal disease, type 2 diabetes, health-care utilisation and costs. Second, to improve risk models for cardiothoracic critical care by enhancing risk factor data and developing models for longer-term mortality. Third, to improve risk models for in-hospital cardiac arrest by enhancing risk factor data and developing models for longer-term mortality and critical care utilisation. Design: Risk modelling study linking existing data. Setting: NHS adult critical care units and acute hospitals in England. Participants: Patients admitted to an adult critical care unit or experiencing an in-hospital cardiac arrest. Interventions: None. Main outcome measures: Mortality at hospital discharge, 30 days, 90 days and 1 year following critical care unit admission; mortality at 1 year following discharge from acute hospital; new diagnosis of end-stage renal disease or type 2 diabetes; hospital resource use and costs; return of spontaneous circulation sustained for > 20 minutes; survival to hospital discharge and 1 year; and length of stay in critical care following in-hospital cardiac arrest. Data sources: Case Mix Programme, National Cardiac Arrest Audit, UK Renal Registry, National Diabetes Audit, National Adult Cardiac Surgery Audit, Hospital Episode Statistics and Office for National Statistics. Results: Data were linked for 965,576 critical care admissions between 1 April 2009 and 31 March 2016, and 83,939 in-hospital cardiac arrests between 1 April 2011 and 31 March 2016. For admissions to adult critical care units, models for 30-day mortality had similar predictors and performance to those for hospital mortality and did not reduce heterogeneity. Models for longer-term outcomes reflected increasing importance of chronic over acute predictors. New models for end-stage renal disease and diabetes will allow benchmarking of critical care units against these important outcomes and identification of patients requiring enhanced follow-up. The strongest predictors of health-care costs were prior hospitalisation, prior dependency and chronic conditions. Adding pre- and intra-operative risk factors to models for cardiothoracic critical care gave little improvement in performance. Adding comorbidities to models for in-hospital cardiac arrest provided modest improvements but were of greater importance for longer-term outcomes. Limitations: Delays in obtaining linked data resulted in the data used being 5 years old at the point of publication: models will already require recalibration. Conclusions: Data linkage provided enhancements to the risk models underpinning national clinical audits in the form of additional predictors and novel outcomes measures. The new models developed in this report may assist in providing objective estimates of potential outcomes to patients and their families. Future work: (1) Develop and test care pathways for recovery following critical illness targeted at those with the greatest need; (2) explore other relevant data sources for longer-term outcomes; (3) widen data linkage for resource use and costs to primary care, outpatient and emergency department data. Study registration: This study is registered as NCT02454257. Funding details: This project was funded by the National Institute for Health and Care Research (NIHR) Health and Social Care Delivery Research programme and will be published in full in Health and Social Care Delivery Research; Vol. 10, No. 39. See the NIHR Journals Library website for further project information.
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- 2022
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40. Prioritizing outcome measures after aneurysmal subarachnoid hemorrhage: A q-sort survey of patients, health care providers and researchers
- Author
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Christopher R. Andersen, Justin Presseau, Victoria Saigle, Emily Fitzgerald, Madeline Lamanna, Phil Talbot, Anthony Delaney, and Shane W. English
- Subjects
subarachnoid hemorrhage ,core outcome set (COS) ,patient reported outcome measure (PROM) ,Q-method analysis ,outcome assessment (health care) ,stroke ,Neurology. Diseases of the nervous system ,RC346-429 - Abstract
ObjectiveTo understand which outcome measures patients and their families, health care providers, and researchers prioritize after aneurysmal subarachnoid hemorrhage (aSAH).MethodsWe conducted a cross-sectional q-sort survey with participants from three key stakeholder groups. Potential outcomes were identified from interviews and focus groups. Participants were purposively sampled to achieve diversity based on stakeholder group, geography, and profession. Respondents sorted 27 outcomes in a quasi-normally distributed grid (Q-Sort) from most to least important. Principal components analysis was used to determine similarities in the way participants sorted the outcome measures resulting in distinct groupings. Overall rankings were also reported.Results112 participants were invited. 70 responded and 64 participants from 25 different countries completed a Q-sort. Balanced stakeholder representation was achieved. Five distinct patterns were identified based on survival, pathophysiological, psychological, resource use, and functional outcome measures. Quality of life as reported by the patient was the highest ranked outcome measure followed by independence and functional measures. Survival and biomedical outcomes were ranked in the middle and cost measures last.ConclusionsIn this diverse sample of key stakeholders, we characterized several distinct perspectives with respect to outcome measure selection in aSAH. We did not identify a clear pattern of opinion based on stakeholder group or other participant characteristics. Patient-reported measure of quality of life was ranked the most important overall with function and independence also highly rated. These results will assist study design and inform efforts to improve outcome selection in aSAH research.
- Published
- 2022
- Full Text
- View/download PDF
41. Evaluation of water fluoridation scheme in Cumbria: the CATFISH prospective longitudinal cohort study
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Michaela Goodwin, Richard Emsley, Michael P Kelly, Matt Sutton, Martin Tickle, Tanya Walsh, William Whittaker, and Iain A Pretty
- Subjects
fluoride ,water fluoridation ,school ,child ,prevalence ,incidence ,dental caries ,cost of illness ,public health ,england ,oral ,dental care ,dentists ,cost savings ,primary health care ,humans ,outcome assessment (health care) ,Public aspects of medicine ,RA1-1270 - Abstract
Background: Water fluoridation was introduced in the UK against a background of high dental decay within the population. Levels of decay have dramatically reduced over the last 40 years following widespread use of fluoride toothpaste. Objective: The aim of the CATFISH (Cumbrian Assessment of Teeth a Fluoride Intervention Study for Health) study was to address the question of whether or not the addition of fluoride to community drinking water, in a contemporary population, lead to a reduction in the number of children with caries and, if so, is this reduction cost-effective? Design: A longitudinal prospective cohort design was used in two distinct recruited populations: (1) a birth cohort to assess systemic and topical effects of water fluoridation and (2) an older school cohort to assess the topical effects of drinking fluoridated water. Setting: The study was conducted in Cumbria, UK. Broadly, the intervention group (i.e. individuals receiving fluoridated drinking water) were from the west of Cumbria and the control group were from the east of Cumbria. Participants: Children who were lifetime residents of Cumbria were recruited. For the birth cohort, children were recruited at birth (2014–15), and followed until age 5 years. For the older school cohort, children were recruited at age 5 years (2013–14) and followed until the age of 11 years. Intervention: The provision of a ‘reintroduced fluoridated water scheme’. Main outcome measures: The primary outcome measure was the presence or absence of decay into dentine in the primary teeth (birth cohort) and permanent teeth (older school cohort). The cost per quality-adjusted life-year was also assessed. Results: In the birth cohort (n = 1444), 17.4% of children in the intervention group had decay into dentine, compared with 21.4% of children in the control group. The evidence, after adjusting for deprivation, age and sex, with an adjusted odds ratio of 0.74 (95% confidence interval 0.56 to 0.98), suggested that water fluoridation was likely to have a modest beneficial effect. There was insufficient evidence of difference in the presence of decay in children in the older school cohort (n = 1192), with 19.1% of children in the intervention group having decay into dentine, compared with 21.9% of children in the control group (adjusted odds ratio 0.80, 95% confidence interval 0.58 to 1.09). The intervention was found to be likely to be cost-effective for both the birth cohort and the older school cohort at a willingness-to-pay threshold of £20,000 per quality-adjusted life-year. There was no significant difference in the performance of water fluoridation on caries experience across deprivation quintiles. Conclusions: The prevalence of caries and the impact of water fluoridation was much smaller than previous studies have reported. The intervention was effective in the birth cohort group; however, the importance of the modest absolute reduction in caries (into dentine) needs to be considered against the use of other dental caries preventative measures. Longer-term follow-up will be required to fully understand the balance of benefits and potential risks (e.g. fluorosis) of water fluoridation in contemporary low-caries populations. Limitations: The low response rates to the questionnaires reduced their value for generalisations. The observed numbers of children with decay and the postulated differences between the groups were far smaller than anticipated and, consequently, the power of the study was affected (i.e. increasing the uncertainty indicated in the confidence intervals). Study registration: This study is registered as Integrated Research Application System 131824 and 149278. Funding: This project was funded by the National Institute for Health and Care Research (NIHR) Public Health Research programme and will be published in full in Public Health Research; Vol. 10, No. 11. See the NIHR Journals Library website for further project information.
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- 2022
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42. Religiosity and Religious Coping in Patients with COPD: A Cross-Sectional Comparison Between Brazil and the Netherlands and Associations with Physical and Psychological Health.
- Author
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Mesquita, Rafael, da Silva, Guilherme P. F., do Nascimento, Francisco Alessandro Braga, Holanda, Marcelo Alcantara, Mont'Alverne, Daniela Gardano Bucharles, de Oliveira Junior, Paulo Vinicius, Janssen, Daisy J. A., and Pereira, Eanes Delgado Barros
- Subjects
- *
WELL-being , *CROSS-sectional method , *COMPARATIVE studies , *OBSTRUCTIVE lung diseases , *BODY movement , *DESCRIPTIVE statistics , *QUALITY of life , *EXERCISE intensity , *PSYCHOLOGICAL adaptation , *RELIGION - Abstract
This study aimed to compare religiosity and religious coping (RC) between Brazilian and Dutch patients with chronic obstructive pulmonary disease (COPD) and to examine associations with physical and psychological health. Religiosity, RC, and physical and psychological health were cross-sectionally assessed in 161 patients with COPD (74 from Brazil and 87 from the Netherlands). Brazilian participants showed the greatest religiosity (p < 0.05), and weak correlations were observed between religiosity/RC and exercise capacity and quality of life (p < 0.05 for all analyses). Brazilian patients with COPD had higher religiosity than Dutch patients, and religiosity correlated with functional exercise capacity and quality of life. [ABSTRACT FROM AUTHOR]
- Published
- 2022
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43. RESULTADOS TERAPÊUTICOS DA HOMEOPATIA EM PACIENTES SUSPEITOS OU CONFIRMADOS DE COVID-19.
- Author
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DANTAS, FLÁVIO
- Abstract
Infection in humans caused by the SARS-CoV-2 virus (COVID-19), diagnosed as pneumonia of unknown cause originally in the city of Wuhan (China) in December 2019, was considered a pandemic by the World Health Organization. Its transmissibility seems to be quite high, affecting almost two million people worldwide and causing more than 130 thousand deaths. It appeared in Brazil in February 2020, initially in the city of São Paulo. It affects more severely the elderly and people with some comorbidities (such as cardiovascular diseases, high blood pressure, diabetes, malignancy, chronic obstructive pulmonary disease and cerebrovascular disease, among others), with a rich clinical symptomatology. Empirical treatments are being tested in more rigorous clinical trials. In the absence of a vaccine to protect the healthy, the strategy of social isolation and treatment with general and / or advanced support measures has been adopted. In this context, it is worth investigating the potential contribution of homeopathy for relieving the distressing symptoms caused by coronavirus in its initial phase, together with monitoring and recording outcomes collected by homeopathic doctors. This national study intends to collect information from suspected or confirmed cases of COVID-19 patients, during the current pandemic in Brazil. The patients will be attended by experienced homeopathic doctors with the prescription of remedies according to the symptoms presented by the patient in the pandemic. All homeopathic medicines are described in the Brazilian Homeopathic Pharmacopoeia. The effects on patients' health status will be evaluated by means of scores and clinical scales, together with measures on safety, duration of the disease and medicines better related with good results. A standardized and specific questionnaire for COVID-19 had been designed and will be available on google forms to be filled out by doctors during the study. The data will be stored in electronic spreadsheets and will be analyzed using descriptive and inferential statistical techniques. All patient data will be collected in a completely anonymous way to protect patients' privacy. Patients will be identified exclusively by an alphanumeric code, to be registered in doctors' medical records. Given the pandemic situation, in cases in which face-to-face health care is not obligatory, an information sheet about the study will be sent to the patient in order to get the informed consent. Teleconsultations will take place in some cases for follow-up of patients. In addition to enlarge telemedicine applications for homeopathy, this project also aims to collect useful information that could be used in future randomized and controlled multicenter trials to evaluate the role of homeopathy in epidemic or transmissible diseases. It could also be helpful for designing clinical studies using homeopathic medicines in other diseases or health problems. [ABSTRACT FROM AUTHOR]
- Published
- 2022
44. Multimodal Ambulatory Monitoring of Daily Activity and Health-Related Symptoms in Community-Dwelling Survivors of Stroke: Feasibility, Acceptability, and Validity.
- Author
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Lau, Stephen C.L., Connor, Lisa Tabor, King, Allison A., and Baum, Carolyn M.
- Abstract
To examine the feasibility, acceptability, and validity of multimodal ambulatory monitoring, which combines accelerometry with ecological momentary assessment (EMA), to assess daily activity and health-related symptoms among survivors of stroke. Prospective cohort study involving 7 days of ambulatory monitoring; participants completed 8 daily EMA surveys about daily activity and symptoms (mood, cognitive complaints, fatigue, pain) while wearing an accelerometer. Participants also completed retrospective assessments and an acceptability questionnaire. Community. Forty survivors of stroke (N=40). Not applicable. Feasibility was determined using attrition rate and compliance. Acceptability was reported using the acceptability questionnaire. Convergent and discriminant validity were determined by the correlations between ambulatory monitoring and retrospective self-reports. Criterion validity was determined by the concordance between accelerometer-measured and EMA-reported daily activity. All participants completed the study (attrition rate=0%). EMA and accelerometer compliance were 93.6 % and 99.7%, respectively. Participants rated their experience with multimodal ambulatory monitoring positively. They were highly satisfied (mean, 4.8/5) and confident (mean, 4.7/5) in using ambulatory monitoring and preferred it over traditional retrospective assessments (mean, 4.7/5). Multimodal ambulatory monitoring estimates correlated with retrospective self-reports of the same and opposing constructs in the predicted directions (r =−0.66 to 0.72, P <.05). More intense accelerometer-measured physical activity was observed when participants reported doing more physically demanding activities and vice versa. Findings support the feasibility, acceptability, and validity of multimodal ambulatory monitoring in survivors of mild stroke. Multimodal ambulatory monitoring has potential to provide a more complete understanding of survivors' daily activity in the context of everyday life. [ABSTRACT FROM AUTHOR]
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- 2022
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45. Made to measure--Selecting outcomes in aneurysmal subarachnoid hemorrhage research.
- Author
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Andersen, Christopher R., English, Shane W., and Delaney, Anthony
- Subjects
SUBARACHNOID hemorrhage ,PATIENT reported outcome measures - Abstract
There has been limited new high-level evidence generated to guide aneurysmal subarachnoid hemorrhage (aSAH) management in the past decade. The choice of outcome measures used in aSAH clinical trials may be one of the factors hindering progress. In this narrative review we consider the current process for determining "what" to measure in aSAH and identify some of the shortcomings of these approaches. A consideration of the unique clinical course of aSAH is then discussed and how this impacts on selecting the best timepoints to assess change in the chosen constructs. We also review the how to critically appraise different measurement instruments and some of the issues with how these are applied in the context of aSAH. We conclude with current initiatives to improve outcome selection in aSAH and future directions in the research agenda. [ABSTRACT FROM AUTHOR]
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- 2022
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46. Construct Validity of the Revised High-Level Mobility Assessment Tool for Children Who Are Developing Typically.
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Hill, Bridget, Eldridge, Beverly, and Williams, Gavin
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- *
STATISTICS , *RELIABILITY (Personality trait) , *CONFIDENCE intervals , *CHILD development , *MULTITRAIT multimethod techniques , *PHYSICAL mobility , *DESCRIPTIVE statistics , *CHI-squared test , *DATA analysis , *CHILDREN - Abstract
Objective The aim of this project was to evaluate the construct validity of the high-level mobility assessment tool (HiMAT) for children who are developing typically with no underlying condition that may affect mobility. Methods The HiMAT is a revised 8-item measure of high-level mobility. Rasch analysis was used to assess fit to the Rasch model indicating unidimensionality, person separation index local dependency, targeting of items, and differential item functioning. Results Children with typical development aged 5 to 12 years (n = 1091; 554 girls and 537 boys) were recruited from 8 schools. The mean HiMAT score was 22.4/32 (range, 8–32). Data fit the Rasch model, indicating that the HiMAT was a unidimensional scale assessing a single construct (high-level mobility). The person separation index was.86, indicating good reliability. The skip item exhibited differential item functioning by sex. Although items were well targeted, the fit residual mean for persons was 2.40, indicating most found the tasks easy to complete. Unlike in adult populations, 2 items (walk and walk over obstacle) exhibited local dependency >0.2. Conclusion The HiMAT is a unidimensional targeted performance measure of high-level mobility for children with typical development aged 5 to 12 years. Further examination of the relationship between the test items "walk" and "walk over an obstacle" may be required to ensure that scores on these items are truly independent of one another. [ABSTRACT FROM AUTHOR]
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- 2022
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47. Comparing the Immune-Genomic Effects of Vilazodone and Paroxetine in Late-Life Depression: A Pilot Study.
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Eyre, Harris, Siddarth, Prabha, Cyr, Natalie, Yang, Hongyu, Cole, Steve, Forbes, Malcolm, and Lavretsky, Helen
- Subjects
Humans ,Paroxetine ,Transcription Factor AP-1 ,Antidepressive Agents ,Cytokines ,Follow-Up Studies ,Pilot Projects ,Double-Blind Method ,Gene Expression Profiling ,Patient Compliance ,Depressive Disorder ,Major ,Psychiatric Status Rating Scales ,Gene Expression Regulation ,Aged ,Aged ,80 and over ,Outcome Assessment (Health Care) ,Female ,Male ,Cyclic AMP Response Element-Binding Protein ,Vilazodone Hydrochloride ,geriatric depression ,gene ,antidepressant ,immune ,inflammation ,Psychiatry ,Pharmacology and Pharmaceutical Sciences - Abstract
Vilazodone is a novel antidepressant agent that combines selective serotonin (5-HT) reuptake inhibitor (SSRI) activity and 5-HT(1A) receptor partial agonist activity. A pilot study was conducted to compare vilazodone (novel compound) and paroxetine (gold standard) on antidepressant effects, tolerability, and inflammation and immune modulation. A 12-week, double-blind, randomized clinical trial was conducted with 56 nondemented older adults diagnosed with major depressive disorder (MDD). Between-group differences in mood, tolerability, and safety, as well as genomic markers of inflammation and immune modulation, were examined. Both treatment groups demonstrated similar improvement in depressed mood. Leukocyte gene expression profiles demonstrated reduction of specific proinflammatory gene transcripts and bioinformatic indications of reduced nuclear factor kappa B (NF-κB), activator protein (AP)-1, and cAMP response element binding (CREB) activity in the vilazodone group compared to the paroxetine group. Transcript origin analyses implicated monocytes and dendritic cells as the primary cellular origins of transcript reductions in the vilazodone-treated group. Vilazodone's antidepressant effects may be associated with reduction of proinflammatory gene expression and immune modulation. Further research is required.
- Published
- 2017
48. Effects of Exercise Therapy and Soft Brace on Knee Osteoarthritis
- Published
- 2019
49. Sustainably Improving Health Care : Creatively Linking Care Outcomes, System Performance and Professional Development
- Author
-
Paul Batalden, Tina Foster, Paul Batalden, and Tina Foster
- Subjects
- Medical policy--Great Britain, Health Personnel, Outcome Assessment (Health Care)
- Abstract
Culture, Context and Quality in Health Sciences Research, Education, Leadership and Patient Care (Second book in a series of five) Sustainably Improving Health Care promotes the importance of integrating improved care outcomes, system performance, and professional development so that the future of health-care advancement is creative and sustainable. It addresses the challenge of creating and nurturing a culture of continuous improvement that is able to sustain and generate creative professional work for the improvement of health care. Using real-world examples, the book succinctly reveals how the model can be practically applied from a variety of different perspectives.'This book makes the persuasive argument that well-intended efforts to redesign and reform health care will enjoy only short lives without the full commitment and engagement of the health-care worker - the product of the sustainability- and capacity-building engine of professional development.'Dave Davis MD, CCFP, FCFP, in the Foreword'This book is about a model that has emerged from our own work, our observations of the work of colleagues and others, and our refl ections about the requirements for the future of the continual improvement of health care. We explore its origins, its content and manifestations, and its implications, particularly for health professional leaders interested in the ongoing improvement of health care. Form and vitality develop in the model as it engages reality - the reality of trying to create cultures of sustainable, generative approaches to the ongoing improvement of health care.'From the Preface
- Published
- 2022
50. Made to measure—Selecting outcomes in aneurysmal subarachnoid hemorrhage research
- Author
-
Christopher R. Andersen, Shane W. English, and Anthony Delaney
- Subjects
subarachnoid hemorrhage ,outcome assessment (health care) ,core outcome set (COS) ,measurement instruments ,patient reported outcome measures ,stroke ,Neurology. Diseases of the nervous system ,RC346-429 - Abstract
There has been limited new high-level evidence generated to guide aneurysmal subarachnoid hemorrhage (aSAH) management in the past decade. The choice of outcome measures used in aSAH clinical trials may be one of the factors hindering progress. In this narrative review we consider the current process for determining “what” to measure in aSAH and identify some of the shortcomings of these approaches. A consideration of the unique clinical course of aSAH is then discussed and how this impacts on selecting the best timepoints to assess change in the chosen constructs. We also review the how to critically appraise different measurement instruments and some of the issues with how these are applied in the context of aSAH. We conclude with current initiatives to improve outcome selection in aSAH and future directions in the research agenda.
- Published
- 2022
- Full Text
- View/download PDF
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