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Abstract Background Genome-wide association studies have identified ATP2B4 as a severe malaria resistance gene. Recently, 8 potential causal regulatory variants have been shown to be associated with severe malaria. Methods Genotyping of rs10900585, rs11240734, rs1541252, rs1541253, rs1541254, rs1541255, rs10751450, rs10751451 and rs10751452 was performed in 154 unrelated individuals (79 controls and 75 mild malaria patients). rs10751450, rs10751451 and rs10751452 were genotyped by Taqman assays, whereas the fragment of the ATP2B4 gene containing the remaining SNPs was sequenced. Logistic regression analysis was used to assess the association between the SNPs and mild malaria. Results The results showed that mild malaria was associated with rs10900585, rs11240734, rs1541252, rs1541253, rs1541254, rs1541255, rs10751450, rs10751451 and rs10751452. The homozygous genotypes for the major alleles were associated with an increased risk of mild malaria. Furthermore, the haplotype containing the major alleles and that containing the minor alleles were the most frequent haplotypes. Individuals with the major haplotypes had a significantly higher risk of mild malaria compared to the carriers of the minor allele haplotype. Conclusions ATP2B4 polymorphisms that have been associated with severe malaria are also associated with mild malaria.

Abstract Introduction Long-term exposure to high-risk human papillomavirus (Hr-HPV) is a well-known necessary condition for development of cervical cancer. The aim of this study is to screen for Hr-HPV using vaginal self-sampling, which is a more effective approach to improve women’s adherence and increase screening rates. Methods This pilot study included a total of 100 Women living with HIV (WLWHIV), recruited from the Center for Listening, Care, Animation, and Counseling of People Living with HIV in Bamako. Hr-HPV genotyping was performed on Self-collected samples using the Cepheid GeneXpert instrument. Results The median age of WLWHIV was 44 (interquartile range [IQR], 37–50) years. Approximately 92% of the study participants preferred self-sampling at the clinic, and 90% opted to receive result notifications via mobile phone contact. The overall prevalence of Hr-HPV among study participants was 42.6%, and the most frequent Hr-HPV sub-types observed were HPV18/45 (19.1%), HPV31/35/33/52/58 (13.8%), and HPV39/68/56/66 (12.8%), followed by HPV16 (5.3%), and HPV51/59 (5.3%). WLWHIV under 35 years of age had a higher frequency of Hr-HPV compared to their older counterparts, with rates of 30% versus 11.1% (p = 0.03). The duration of antiretroviral treatment showed an inverse association with Hr-HPV negativity, with patients on treatment for 15 (IQR, 10–18) years versus 12 (IQR = 7–14) years for Hr-HPV positive patients (95% CI [1.2–5.8], t = 3.04, p = 0.003). WLWHIV with baseline CD4 T-Cell counts below 200 exhibited a higher frequency of Hr-HPV compared to those with baseline CD4 T-Cell counts above 200 (17.9% versus 1.9%, p = 0.009). However, other demographics and clinical factors, such as marital status, age of sexual debut, parity, education, history of abortion, history of preeclampsia, and cesarean delivery, did not influence the distribution of Hr-HPV genotypes. Conclusion Our findings indicate that WLWHIV under the age of 35 years old exhibited the highest prevalence of Hr-HPV infection, with HPV18/45 being the most prevalent subtype. Additionally, WLWHIV with baseline CD4 T-Cell counts below 200 showed the highest infection rates.

Spatio-temporal analysis of rainfall trends in a watershed is an effective tool for sustainable water resources management, as it allows for an understanding of the impacts of these changes at the watershed scale. The objective of the present study is to analyze the impacts of climate change on the availability of surface water resources in the Nakanbe–Wayen watershed over the period from 1981 to 2020. The analysis was conducted on in situ rainfall data collected from 14 meteorological stations distributed throughout the watershed and completed with CHIRPS data. Ten precipitation indices, recommended by the ETCCDI (Expert Team on Climate Change Detection and Indices), were calculated using the RClimDex package. The results show changes in the distribution of annual precipitation and an increasing trend in annual precipitation. At the same time, a trend towards an increase in the occurrence and intensity of extreme events was also observed over the last 4 decades. In light of these analyses, it should be emphasized that the increase in precipitation observed in the Nakanbe–Wayen watershed is induced by the increase in the occurrence and intensity of events, as a trend towards an increase in persistent drought periods (CDD) is observed. This indicates that the watershed is suffering from water scarcity. Water stress and water-related hazards have a major impact on communities and ecosystems. In these conditions of vulnerability, the development of risk-management strategies related to water resources is necessary, especially at the local scale. This should be formulated in light of observed and projected climate extremes in order to propose an appropriate and anticipated management strategy for climate risks related to water resources at the watershed scale.

Methylenetetrahydrofolate reductase (MTHFR) plays a major role in the metabolism of folates and homocysteine, which in turn can affect gene expression and ultimately promote the development of breast cancer. Thus, mutations in the MTHFR gene could influence homocysteine, methionine, and S-adenosylmethionine levels and, indirectly, nucleotide levels. Imbalance in methionine and S-adenosylmethionine synthesis affects protein synthesis and methylation. These changes, which affect gene expression, may ultimately promote the development of breast cancer. We therefore hypothesized that such mutations could also play an important role in the occurrence and pathogenesis of breast cancer in a Malian population. In this study, we used the PCR-RFLP technique to identify the different genotypic profiles of the C677T MTHFR polymorphism in 127 breast cancer women and 160 healthy controls. The genotypic distribution of the C677T polymorphism in breast cancer cases was 88.2% for CC, 11.0% for CT, and 0.8% for TT. Healthy controls showed a similar distribution with 90.6% for CC, 8.8% for CT, and 0.6% for TT. We found no statistical association between the C677T polymorphism and breast cancer risk for the codominant models CT and TT p>0.05. The same trend was observed when the analysis was extended to other genetic models, including dominant (p = 0.50), recessive (p = 0.87), and additive (p = 0.50) models. The C677T polymorphism of MTHFR gene did not influence the risk of breast cancer in the Malian samples.

This research note proposes a reflection on indigenous urbanities and environmental governance. In Canada, the scientific literature has extensively studied the models of governance and the co-management of resources in indigenous territories, emphasizing their important natural resources and the existence of cosmologies that can contribute in an alternative way to collective action in the face of contemporary socio-ecological challenges. While most indigenous people in Quebec live outside the reserve, little work has been dedicated to the governance models involving indigenous people in urban areas, and even less on the environment. The dominant modes of governance have also been criticized on the grounds that they risk perpetuating unequal frameworks of collaboration and hindering truly inclusive governance. One of the reasons for this is that colonial power structures tend to disqualify alternative epistemologies and practices. In this regard, the urban context requires a reconsideration of the issues associated with governance in the face of contemporary socio-ecological challenges due to the diversity of actors involved, which is what this article focuses on by critically examining the relevant literature. The presence of Aboriginal people in Canada's major urban centers is not new, and their absence from environmental governance seems to reflect a lack of recognition of this reality and the exclusion of their perspectives. To remedy this, urban governance should be rethought from the point of view of the representativeness of the different voices as well as alternative models of considering the commonality that Aboriginal people can enrich the city with.

This article explores the controversy surrounding Canada’s seal hunt and the related “anti-sealing” media campaigns since the 1960s. Based on this case, it proposes to engage in an epistemological and critical reflection on contemporary socio-ecological challenges and human-environmental relationships that require a shift in thinking from the dominant discourses on injunctions to global political actions for “conservation” and “animal welfare”. This reflection is based on the Inuit’s agentivity in this controversy since the moral dimension of the seal hunting issue has contributed to making their voice inaudible and has effectively affected their communities. The subaltern Inuit counter-narrative contributes to grasping the unthought of the dominant discourses in the media sphere and challenges us with regard to the representations of a practice deemed immoral by some, but held as perfectly ethical by others.

In this paper, we position the societal expectation of the ‘grateful refugee’ in the larger European script of placing migrant help and integration. We ask how might we re-imagine geographies of migrant ‘help’ so as to break with the dominant ontologies of places as sites embedded within the nation-state and the accompanying relations of power which displace the migrant in a perpetual penumbra of gratefulness? By montaging a series of contrapuntal vignettes of borderlands producing Europe, we examine the moral geographies of help and debt and how geographical imaginations of place and place-identities of practices of refugee-help today are entangled with mid-20th century wartime aid. Drawing inspiration from the negritude movement, we argue that such ‘untimely articulations’ produce ‘sites of décalage’ where Europe (as manifesting in such entangled moral geo-histories of help) is no longer Europe, suggesting an initial vocabulary for a radical politics of place.

Abstract Background The effect of the p.Arg72Pro variant of the P53 gene on the risk of development ofbreast cancer remains variable in populations. However, the use ofstrategies such aspoolingage-matched controls with disease may provide a consistent meta-analysis. Our goal was to perform a meta-analysis in order to assess the association of p.Arg72Pro variant of P53 gene with the risk of breast cancer. Methods Databases such as PubMed, Genetics Medical Literature, Harvard University Library, Web of Science and Genesis Library were used to search articles. Case-control studies with age-matched on breast cancer havingevaluated the genotype frequencies of the TP53 p.Arg72Pro polymorphism were selected. The fixed and random effects (Mantel-Haenszel) were calculated using pooled odds ratio of 95% CI to determine the risk of disease. Inconsistency was calculated to determine heterogeneity among the studies. The publication bias was estimated using the funnel plot. Results Twenty-one publications with 7841 cases and 8876 controls were evaluated in this meta-analysis. Overall, our results suggested that TP53 p.Arg72Pro was associated with the risk of breast cancer for the dominant model (OR = 1.09, 95% CI = 1.02–1.16, P = 0.01) and the additive model (OR = 1.09, 95% CI = 1.01–1.17, P = 0.03), but not for the recessive model (OR = 1.07, 95% CI = 0.97–1.18, P = 0.19). According to the ethnic group analysis, Pro allele was associated with the risk of breast cancer in Caucasians for the dominant model and additive model (P = 0.02), and Africans for the recessive model and additive model (P = 0.03). Conclusions This meta-analysis found a significant association between TP53 p.Arg72Pro polymorphism and the risk of breast cancer. Individuals carrying at least one Pro allele were more likely to have breast cancer than individuals harboring the Arg allele.

Abstract Background Breast cancer, the most common tumor in women in Mali and worldwide has been linked to several risk factors, including genetic factors, such as the PIN3 16-bp duplication polymorphism of TP53. The aim of our study was to evaluate the role of the PIN3 16-bp duplication polymorphism in the susceptibility to breast cancer in the Malian population and to perform a meta-analysis to better understand the correlation with data from other populations. Methods We analyzed the PIN3 16-bp duplication polymorphism in blood samples of 60 Malian women with breast cancer and 60 healthy Malian women using PCR. In addition, we performed a meta-analysis of case-control study data from international databases, including Pubmed, Harvard University Library, Genetics Medical Literature Database, Genesis Library and Web of Science. Overall, odds ratio (OR) with 95% CI from fixed and random effects models were determined. Inconsistency was used to assess heterogeneity between studies and publication bias was estimated using the funnel plot. Results In the studied Malian patients, a significant association of PIN3 16-bp duplication polymorphism with breast cancer risk was observed in dominant (A1A2 + A2A2 vs. A1A1: OR = 2.26, CI 95% = 1.08–4.73; P = 0.02) and additive (A2 vs. A1: OR = 1.87, CI 95% = 1.05–3.33; P = 0.03) models, but not in the recessive model (P = 0.38). In the meta-analysis, nineteen (19) articles were included with a total of 6018 disease cases and 4456 controls. Except for the dominant model (P = 0.15), an increased risk of breast cancer was detected with the recessive (OR = 1.46, 95% CI = 1.15–1.85; P = 0.002) and additive (OR = 1.11, 95% CI = 1.02–1.19; P = 0.01) models. Conclusion The case-control study showed that PIN3 16-bp duplication polymorphism of TP53 is a significant risk factor for breast cancer in Malian women. These findings are supported by data from the meta-analysis carried out on different ethnic groups around the world.

A literature review showed some discrepancies regarding the association of -592C/A with the risk of cervical cancer. To allow more precise analysis of the data by increasing the number of cases studied and more acceptable generalization by considering results from different sources, the present meta-analysis was performed on available published studies that explored the relationship between SNP-592C/A of the IL-10 gene and the risk of cervical cancer. Eleven available studies, including 4187 cases and 3311 controls, were included in this study investigating the relationship between the -592C/A polymorphism of IL-10 and cervical cancer risk. Fixed-effects or random-effects models were performed with pooled odds ratios (ORs). Heterogeneity and bias tests were performed by the inconsistency test and funnel plot, respectively. The overall analysis showed an increased susceptibility to cervical cancer with the -592C/A polymorphism of the IL-10 gene for the recessive model (OR = 1.30, 95% CI = 1.14–1.49), dominant model (OR = 1.36, 95% CI = 1.09–1.70), and additive model (OR = 1.25, 95% CI = 1.09–1.44). Regarding ethnicity, a significant association of the -592C/A polymorphism of the IL-10 gene was linked to an elevated risk of cervical cancer for all genetic models (recessive, dominant, and additive) in the Asian populations and for the recessive and additive models in Caucasians with P

In this empirical study, we collected about 6.8 million tweets that mentioned “fake news”, and we extracted references to climate change and/or global warming to understand the public discourses around these two issues. Using a mixed method, the study’s findings show that there is a clear politically polarized discussion on climate change. We found that the majority of tweets focus on the United States context though references to other Western coutnries are often made. The anti-Liberal or anti-Democratic online community was more active on Twitter than the anti-conservative or anti-Republican community. Also, more than half the examined most retweeted posts contained claims about climate change being a natural cycle or even denying it exists, while about a third of these tweets stated that climate change was anthropogenic. The implications of the study are discussed, we argue that fake news as a term has a hollow meaning as it is used as a buzzword to discredit opponents and further the political agenda of different parties not only in the United States but also in other Western countries like Australia.

INTRODUCTION: Currently, the non-steroid anti-inflammatory drugs constitute a veritable object of auto medication throughout the world. The goal of this study was to evaluate the endoscopic and clinical aspects of gastro-duodenal ulcer secondary to taking of non-steroid anti-inflammatory of various sources. METHODS: this was a cross-sectional study which conducted between July 2016 and December 2017. All adult patients admitted to hospital for clinical symptoms suggestive of gastroduodenal involvement after taking anti-inflammatory drugs and having undergone upper digestive endoscopy were included in this study. Data analysis was done with Epi-info version 7 Software. RESULTS: a total of 114 patients were included, the mean age was 47.18±26 years with a male predominance (64.9%). Among the patients, only 1.75% had taken a non-steroid anti-inflammatory (NSAIDs) from pharmacy. The NSAIDs used were of different types: diclofenac, aceclofenac, aspirin and non-selective NSAIDs. For each drug used, more than half were derived from the streets. Clinically we noted: the dyspepsia (38.58%), hemorrhages (11.40%), the ulcerous syndrome (77.19%), haematemesis (19.29%), haematemesis associated with melena (37.71%), and the rectorrhagia in 6.14 of cases. The specific endoscopic lesions were bulbar ulcer (45.61%), gastric ulcers (20.17%), antral ulcerations (5.26%) and acute gastritis (9.64%), esophagitis (7.89%), esophageal varices (6.14%), and uncomplicated hiatal hernia in 7.01% of cases. CONCLUSION: the serious gastroduodenal lesions observed in this study and due to use of NSAIDs are mainly attributable to unauthorized molecules due to safety concerns. It would be necessary to conduct sensitization days at the community level and in each health facility.

Les cardiopathies congénitales surviennent dans 0.5-1% des naissances. La prise en charge d’enfants souffrant de malformation cardiaque nécessite un centre adapté, un matériel médical adéquat et des connaissances particulières tant sur le plan anesthésique que chirurgical. L’objectif de ce travail était d’évaluer la prise en charge anesthésique de ces cardiopathies dans notre centre après une première année d’activité et de comparer les résultats obtenus aux données de la littérature. Nous avons mené une étude rétrospective, descriptive sur une année allant de janvier à décembre 2017. Ont été inclus tous les patients opérés au cours de cette période pour une cure de cardiopathie congénitale sous circulation extracorporelle. Nous avons colligé 80 dossiers de patients opérés pour une cardiopathie congénitale. Parmi ces 80 patients, 60 ont été opéré sous CEC soit un taux de 75%. L’âge moyen de nos patients était de 7,41 ans avec un sex- ratio de 1,22. La durée de la CEC était en moyenne de 82,82 mn et la durée moyenne du clampage aortique était de 58,31 mn. 70% des patients ont eu des catécholamines en fin d’intervention. La complication la plus fréquente en post opératoire était la défaillance cardiaque droite (69%). La durée moyenne de séjour en réanimation était de 4,33 jours. Nous avons noté le décès d’un patient portant la mortalité à 1,6%. Les cardiopathies congénitales sont complexes et très variables. Avec l’amélioration des techniques de prise en charge, leur morbi-mortalité a fortement diminué.

La COVID-19 est due au virus SRAS-CoV-2 génétiquement semblable au virus du syndrome respiratoire aigu sévère (SRAS). En pédiatrie, les formes cliniques ont un caractère bénin. En Guinée, suite à la pandémie du COVID-19 dont l´épicentre était Conakry, des cas pédiatriques ont été observés au CTEPI de Donka. L´objectif de cette étude était de déterminer leur profil épidémiologique. Etude transversale de type descriptif de 04 mois chez les enfants de 0 à 16 ans admis au CTEPI Donka. Sur 7308 patients provenant principalement des 5 communes de Conakry hospitalisés au CTEPI, 189 étaient âgés de 0 à 16 ans, soit 2, 59%. La tranche de 0-4 ans était plus représentée (38,62%) avec un sex-ratio (F/M) de 1,52; 62,96% étaient des élèves, 70% des enfants résidaient à Conakry, 28,57% des mères étaient des marchandes et personnes contactes dans 39,68%; 37,57% des pères étaient des fonctionnaires, 2,65% des enfants avaient des antécédents de drépanocytose et 1,59% de rhinite allergique. Les cas asymptomatiques représentaient 52,38% et les cas confirmés 74, 6%; les symptômes étaient: fièvre, rhinorrhée, céphalées, toux, douleurs abdominales, éternuement, diarrhée, asthénie physique. La proportion des cas pédiatriques infectés au COVID-19 au CTEPI de Donka est faible. Les enfants de 5 ans et plus sont plus concernés et près de 50% était asymptomatique. Les symptômes dominants sont: fièvre, céphalées, rhinorrhée, toux, douleurs abdominales, éternuement, diarrhée, asthénie physique.

The presence of Helicobacter pylori is a major contributor to the genesis of peptic ulcer disease, although its role in the pathogenesis of ulcer in cirrhotic patients is yet to be well established. The aim of this work is to determine the prevalence of gastroduodenal lesions associated with histologically confirmed Helicobacter pylori in cirrhotic patients. This was a retrospective study witch conducted from January 2017 to May 2018 at Sikasso Hospital. The inclusion criteria were: presence of cirrhosis, endoscopic gastroduodenal lesions for which histological confirmation of the presence of Helicobacter pylori biopsies was made. The collected data was analyzed by Epi Info software version 7.0. Thirty four patients have been included, the mean age was 38±17 years and a male/female sex ratio of 2.09. Gastrointestinal symptoms included epigastralgia (26.47%), nausea (8.82%), early postprandial vomiting (5.88%) and hematemesis (8.82%). Esophagogastroduodenoscopy revealed esophageal varices in 47%, which 1 case of esophageal varices grade III with red signs, 5.88% grade II with red signs, 8.82% grade I without red signs. A case of portal hypertension gastropathy was noted in 12 patients and gastroduodenal lesions in 33%. Anatomopathological examination of the biopsies revealed Helicobacter pylori in 57%, active chronic gastritis in 44.11% and chronic gastritis with intestinal metaplasia in 2.94% of cases. This study reveals a fairly high frequency of Helicobacter pylori in digestive lesions observed in cirrhotic patients. Helicobacter pylori infection in cirrhotic patients requires urgent therapeutic management to prevent the possible hemorrhagic complications.

This article focuses on the rise of the environmental theme in international communication institutions and discourses. Through a content analysis of a body of theoretical work and institutional documents dating back to the 1970s, the author traces the main stages of the rise of environment as an object of concern in international communication research. It appears that development and environmental issues have emerged with a certain time lag and that the communication dimension has long remained peripheral for environmental issues while it was quickly central to development issues. Focusing on the historical mobilization of the question of “resources”, the author shows that, while it is central today for the paradigm of “sustainable development”, its genealogy is older since it has previously structured the stakes around information flows (information paradigm: C4D) and orbits and frequencies (telecommunication paradigm: ICT4D) before applying to the environmental question (ecological paradigm). The author relies on this critical genealogy of the epistemic and institutional constitution of the field of research to suggest a normative model based on an ethic of responsibility (inspired by Hans Jonas) and on two metaconditions: a horizontal principle of participation (communicative) and a principle of resilience (ecological).

The heterogeneous reaction of NO2on Saharan sand collected from different locations has been studied at 298 K and 25% relative humidity using a horizontal coated-wall flow tube. The sand samples originated from Mauritania, Algeria, Morocco and Tunisia and were taken as simplified proxies for mineral dust. While the uptake in the dark was always very small, a photo-enhanced uptake of NO2was observed on all four samples showing that natural minerals do have a photochemical activity. The uptake coefficient γBETwas measured for all sands. In the dark, the γBETvalues are (1.60 ± 0.24) × 10−8, (0.43 ± 0.06) × 10−8, (0.94 ± 0.14) × 10−8and (0.59 ± 0.09) × 10−8for the samples from Mauritania, Algeria, Morocco and Tunisia, respectively. Under realistic atmospheric conditions, the observed photo-enhancement leads to uptake coefficients of (1.46 ± 0.21) × 10−7, (0.35 + 0.05) × 10−7, (1.30 ± 0.19) × 10−7and (0.89 ± 0.13) × 10−7, respectively, i.e.an enhancement factor ranging from 8 to 15. This study shows that the photochemistry of natural minerals will impact significantly on the heterogeneous chemistry of NO2. [ABSTRACT FROM AUTHOR]

This work is based on weather data from Ouagadougou and Ouahigouya to examine the changes that have affected rainfall, relative humidity (RH) and potential evapotranspiration (FTE) and the impact of these changes on the duration of favorable periods for rainfed crops growth from 1956 to 2015. Pettitt's test and Hubert's segmentation procedure revealed several breaks of homogeneity localized in : (i) 1981 (Ouagadougou), 1973 and 1995 (Ouahigouya) for rainfall, (ii) 1984 (Ouagadougou) for HR, (iii) 1985 and 1994 (Ouagadougou), 1978 and 1992 (Ouahigouya) for ETP. This climatic dynamic goes with a shortening of the wet season duration of -25 % in Ouagadougou and -3 % in Ouahigouya. This shortening is mainly due to the decrease in the duration of the wet periods, which fell by -37 % in Ouagadougou and -12 % in Ouahigouya. Similarly, the duration of the active vegetation period decreased from 102 days before break to 48 days after break (-59 % decrease) in Ouagadougou and from 67 days before break to 21 days after break (-38 % decrease) in Ouahigouya. The diagnosis of climate variability and its impact on the duration of rainfed crops growth periods across the country will better characterize agro-climatic dynamics in order to guide the development of appropriate adaptation strategies.

Building on an in-depth analysis of the core literature grappling with the philosophical problematization of communication, this article examines the oft-asserted interdisciplinary nature of communication studies by assessing some of its underlying presuppositions at the ontological and epistemological levels. The article evaluates the coherence of our fragmented discipline through the articulation of the categories of the One and the Multiple in ontological and epistemological directions. In doing so, the recurrent conception of communication studies as an interdiscipline is criticized while recognizing the importance of undertaking interdisciplinary research within the field. Are especially considered the historical roots of interdisciplinary advocacies, namely the institutional demands for interdisciplinarity that have often resulted in conceptions of communication studies by communication scholars themselves as a crossroads or a service discipline. Building from Ernst Cassirer’s developments regarding the “theory of the concept’’, the author contends in the final section of the paper that the solution to the lack of coherence of the field lies in the necessity for communication studies to discipline themselves in order for the research undertaken within the field to acquire a common framework of intelligibility.

The study aims to identify areas where agro-pastoralists access to water during the dry season in the drainage basin of the river Goudébo. The approach is the spatial reference analysis AMC-RS based on Geographic Information System and Multi-Criteria Analysis. Water points used for different needs (boulis, drillings, ponds, tanks, sumps, wells and dams) were identified with the people. Cartographic documents and field surveys have constitute, through the GIS, a map database of these elements. Taking into account the travel times allowed a spatial representation of the accessibility to water points. The AMC-RS were made from the results of GIS, on the basis of criteria proposed by the people during the interviewing sessions. The results of the analysis gave 7.4 % of areas with a high level of aggregate access to different types of water point. These relatively small areas are circumscribed around 40 % of the villages. The importance taken by dams, and particularly that of Yakouta, puts the problem of the management of their feed area in the future.geographic information system, multi-criteria analysis, access to water, Burkina Faso

The hermeticism and aphoristic style of Marshall McLuhan probably affected the scientific reception of his work. Nevertheless, the writings of the Canadian author still continue to attract both criticisms and praise. In this paper, we provide a brief account of his contribution. After reviewing some of the ideas of thinkers to whom McLuhan himself is indebted, we address the posterity of his writings and evoke the most recurrent criticisms of his work. The paper ends by mentioning how McLuhan imported approaches mobilized in literary theory in the 1930s into media analysis and by calling on Harold Innis’ approach to complement that of McLuhan.

'Superior mesenteric artery syndrome is a rare complication occurring after surgical treatment for scoliosis. Surgical correction of the scoliotic spine produces vertical traction on the mesenteric artery and the narrowing of the aortomesenteric angle, hence the compression of the third part of the duodenum causing the syndrome. We here report the case of a young girl with an early form of superior mesenteric artery syndrome secondary to surgical correction of idiopathic scoliosis. The patient underwent posterior spinal fusion for idiopathic scoliosis. On the third postoperative day she experienced uncontrollable vomiting associated with no evacuation of faeces and no passing of flatus. Urgent abdominal CT scan was performed which allowed the diagnosis of superior mesenteric artery syndrome. Treatment consisted in the rest of the digestive tract associated with early parenteral nutrition and correction of fluid and electrolyte imbalances. Lacking evidence of clinical improvement, surgical indication was posed. The evolution was favourable with an uneventful postoperative recovery and the resumption of adequate food intake on the fourth postoperative day. The patient was discharged on the seventh postoperative day. Contributing factors are young age, long-limbed morphotype with BMI below 18. CT scan shows an important gastric dilatation associated with complete halt of the third part of the duodenum. The treatment is multidisciplinary, medical (first-line treatment) and surgical (if medical treatment do not help). A better knowledge of the predictors of medical treatment failure would reduce the length of hospital stay.

Abstract Background Although considered a public health issue in Senegal, the actual incidence and mortality from snakebite are not known. In the present study, an epidemiological survey was carried out in Kédougou region, southeastern Senegal, where envenomations, particularly by Echisocellatus, are frequent and severe. Methods Three sources of data were used: records from health centers and reports by health professionals; traditional healers; and household surveys. Results The annual incidence and mortality provided by health centers were 24.4 envenomations and 0.24 deaths per 100,000 population, respectively. The annual incidence recorded by traditional healers was 250 bites per 100,000 inhabitants, but the number of deaths was unknown. Finally, the household surveys reported an annual incidence of 92.8 bites per 100,000 inhabitants and an annual mortality rate of 2.2 deaths per 100,000 inhabitants. The differences in incidence and mortality between the different methods were explained by significant bias, resulting in particular from the complex patient's healthcare-seeking behavior. The incidence provided by health records should be used to specify the immediate quantitative requirements of antivenoms and places where they should be available first. Conclusion Mandatory reporting of cases would improve the management of envenomation by simplifying epidemiological surveys. Patients' preference for traditional medicine should prompt health authorities to urge traditional healers to refer patients to health centers according to defined clinical criteria (mainly edema and bleeding or neurotoxic symptoms). Finally, household surveys were likely to reflect the actual epidemiological situation. Poison Control Center of Senegal should continue its work to sensitize stakeholders and train health staff.

This article establishes a dialogue between the work of Jack Goody and that of Harold Innis and Clarisse Herrenschmidt. First, the concepts of modes of communication and technologies of the intellect elaborated by Goody are contrasted with the development of media by Innis. The two authors’ approaches to knowledge and power are analyzed through the emphasis placed on written culture by Goody and on monopolies of knowledge by Innis. The paper reviews convergences and differences with regard to both the production of the social and cognitive processes. Goody's contribution is then analyzed in relation to the more recent work of Herrenschmidt who, by pluralizing and historicizing writing, highlights the question of the code that is central to computer writing. This three-way dialogue through the mediating figure of Goody sheds original light on relationships between media and society.

Long-chain fatty acids (FAs) are the major substrates fueling brown adipose tissue (BAT) thermogenesis. Investigation of mouse models has previously called into question the contribution of brown adipocyte intracellular lipolysis to cold-induced non-shivering thermogenesis. Here, we determined the role of the lipolytic enzymes, adipose triglyceride lipase (ATGL) and hormone-sensitive lipase (HSL), in BAT thermogenesis. Brown fat from mice with inducible brown-adipocyte-specific deletion of ATGL and HSL (BAHKO) is hypertrophied with increased lipid droplet size and preserved mitochondria area and density. Maintenance of body temperature during cold exposure is compromised in BAHKO mice in the fasted but not in the fed state. This altered response to cold is observed in various thermal and nutritional conditions. Positron emission tomography-computed tomography using [ 11 C]-acetate and [ 11 C]-palmitate shows abolished cold-induced BAT oxidative activity and impaired FA metabolism in BAHKO mice. Our findings show that brown adipocyte intracellular lipolysis is required for BAT thermogenesis., Competing Interests: Declaration of interests The authors declare no competing interests., (Copyright © 2024 The Author(s). Published by Elsevier Inc. All rights reserved.)