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599 results on '"Oude Voshaar, Richard C."'

9. The effect of a multicomponent exercise protocol (VIVIFRAIL©) on inflammatory profile and physical performance of older adults with different frailty status: study protocol for a randomized controlled trial

Author

Petrella, Marina, Aprahamian, Ivan, Mamoni, Ronei Luciano, de Vasconcellos Romanini, Carla Fernanda, Lima, Natália Almeida, de Cássio Robello, Everson, da Costa, Daniele Lima, An, Vinicius Nakajima, Aguirre, Bianca Nobre, Galdeano, Júlia Riccetto, Fernandes, Isabela Cunha, Soleman Hernandez, Salma S., Cesari, Matteo, Morley, John E., Izquierdo, Mikel, and Oude Voshaar, Richard C.

Published
2021
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16. Age‐related subtypes of late life depression and mortality: A prospective clinical cohort study.

Author

Lugtenburg, Astrid, Zuidersma, Marij, Rius Ottenheim, Nathaly, Rhebergen, Didi, and Oude Voshaar, Richard C.

Subjects
MORTALITY risk factors, COGNITION disorders, FRAIL elderly, CONFIDENCE intervals, GERIATRIC assessment, RISK assessment, COMPARATIVE studies, MENTAL depression, LONGITUDINAL method, OLD age
Abstract

Objectives: Late Life Depression (LLD) is associated with increased mortality rates, but it remains unclear which depressed patients are at increased risk. This study examined the mortality risk of previously identified subgroups of depressed older patients based on age‐related clinical features (the presence of physical and cognitive frailty). Methods: A six‐year follow‐up of a clinical cohort study including 375 depressed older patients and 132 non‐depressed persons (NESDO). Depressed patients were diagnosed with the Composite International Diagnostic Interview (CIDI) according to DSM‐IV criteria and classified by latent profile analysis on depressive symptom severity, cognitive domains and physical frailty. We estimated the hazard rate of mortality for the four depressed subgroups compared to non‐depressed persons by applying Cox‐regression analyses. Models were adjusted for age, sex and education as confounders and for explanatory variables per pathway in separate models: somatic burden, lifestyle characteristics, vascular burden or inflammation markers. Results: A total of 61/375 (16.3%) depressed patients and 8/132 (6.1%) non‐depressed persons died during the 6‐year follow‐up. Two of the four subgroups (n = 186/375 (50%) of the depressed sample) had a higher hazard rate (HR) for mortality compared to non‐depressed participants, that is, frail‐depressed patients (HR = 5.25, [95%‐CI: 2.13–13.0]) and pure mild depressed patients (HR = 3.32 [95%‐CI: 1.46–7.58]) adjusted for confounders. Adding possible underlying pathways did not explain these associations. Conclusions: Age‐related features (the presence of physical and cognitive frailty) contribute to the increased mortality risk in late‐life depression. Future studies in depressed older patients should study the additional value of a clinical geriatric assessment and integrated treatment aimed to at reduce frailty and ameliorate their mortality risk. Key points: Ageing related features (the presence of physical and cognitive frailty) contribute to the increased mortality risk in late life depressionDepressive symptom severity may not be independent related to the mortality in late‐life depression.Geriatric interventions aimed at reducing frailty in late life depression may ameliorate the mortality risk. [ABSTRACT FROM AUTHOR]

Published
2024
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19. Design and protocol of the multimorbidity and mental health cohort study in frailty and aging (MiMiCS-FRAIL): unraveling the clinical and molecular associations between frailty, somatic disease burden and late life depression

Author

Aprahamian, Ivan, Mamoni, Ronei Luciano, Cervigne, Nilva Karla, Augusto, Taize Machado, Romanini, Carla Vasconcelos, Petrella, Marina, da Costa, Daniele Lima, Lima, Natalia Almeida, Borges, Marcus K., and Oude Voshaar, Richard C.

Published
2020
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22. Well-being, multidisciplinary work and a skillful team: essential elements of successful treatment in severe challenging behavior in dementia.

Author

van Voorden, Gerrie, Koopmans, Raymond T.C.M., Smalbrugge, Martin, Zuidema, Sytse U., van den Brink, Anne M.A., Persoon, Anke, Oude Voshaar, Richard C., and Gerritsen, Debby L.

Subjects
TREATMENT of dementia, WELL-being, MEDICAL quality control, PSYCHIATRIC drugs, ATTITUDES of medical personnel, MEDICAL personnel, PATIENT-centered care, TREATMENT effectiveness, HEALTH care teams, PROFESSIONAL competence, PSYCHOSOCIAL factors, RESEARCH funding, SUCCESS
Abstract

Conceptualize successful treatment of persons with dementia and severe challenging behavior as perceived by professionals. In this concept mapping study 82 experts in dementia care participated. The study followed two phases of data collection: (1) an online brainstorm where participants completed the focus prompt: 'I consider the treatment of people with severe challenging behavior in dementia successful if.'; (2) individual sorting and rating of the collected statements followed by data analysis using multidimensional scaling and hierarchical cluster analysis, resulting in a concept map. Three clusters were identified, the first addressing treatment outcomes and the latter two addressing treatment processes, each divided into sub-clusters: (1) well-being, comprising well-being of the person with dementia and all people directly involved; (2) multidisciplinary analysis and treatment, comprising multidisciplinary analysis, process conditions, reduction in psychotropic drugs, and person-centered treatment; and (3) attitudes and skills of those involved, comprising consistent approach by the team, understanding behavior, knowing how to respond to behavior, and open attitudes. Successful treatment in people with dementia and severe challenging behavior focuses on well-being of all people involved wherein attention to treatment processes including process conditions is essential to achieve this. [ABSTRACT FROM AUTHOR]

Published
2023
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23. Effects of Pharmacogenetic Screening for CYP2D6 Among Elderly Starting Therapy With Nortriptyline or Venlafaxine: A Pragmatic Randomized Controlled Trial (CYSCE Trial)

Author

van der Schans, Jurjen, Hak, Eelko, Postma, Maarten, Breuning, Laura, Brouwers, Jacobus R.B.J., Ditters, Kaspar, Jansen, Paul A.F., Kok, Rob M., Maring, Jan G., van Marum, Rob, Mulder, Hans, Nanninga, Jaap, Oude Voshaar, Richard C., Risselada, Arne J., Vleugel, Liesbeth, Stek, Max, van Schaik, Ron H.N., Berm, Elizabeth J.J., and Wilffert, Bob

Published
2019
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28. Study design of the Routine Outcome Monitoring for Geriatric Psychiatry & Science (ROM-GPS) project; a cohort study of older patients with affective disorders referred for specialised geriatric mental health care

Author

Oude Voshaar, Richard C., Dhondt, Ton D. F., Fluiter, Mario, Naarding, Paul, Wassink, Sanne, Smeets, Maureen M. J., Pelzers, Loeki P. R. M., Lugtenburg, Astrid, Veenstra, Martine, Marijnissen, Radboud M., Hendriks, Gert-Jan, Verlinde, Lia A., Schoevers, Robert A., and van den Brink, Rob H. S.

Published
2019
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30. Feasibility, usability and clinical value of intensive longitudinal diary assessments in older persons with cognitive impairment and depressive symptoms.

Author

Zuidersma, Marij, Müller, Fabiola, Snippe, Evelien, Zuidema, Sytse U., and Oude Voshaar, Richard C.

Subjects
COGNITION disorders, PILOT projects, USER-centered system design, ACTIGRAPHY, DIARY (Literary form), SURVEYS, SLEEP, MENTAL depression, QUESTIONNAIRES, RESEARCH funding
Abstract

To evaluate the feasibility, usability and clinical value of daily diary assessments combined with actigraphy in older persons with cognitive impairment. For 63 days, patients ≥60 years with cognitive impairments filled out a daily diary (including standardized questionnaires and cognitive test battery), and wore an actiwatch (sleep). After the study, participants and clinicians received personal feedback about patterns and daily triggers of depressive symptoms, sleep and cognitive performance. We assessed feasibility (participation rate, compliance and subjective burden), usability (variability and floor- or ceiling effects) and clinical value for patients and their clinicians (questionnaires). Of 96 eligible patients, 13 agreed to participate (13.5%). One patient dropped out after 2 days, another after 37 days, and another did not complete the cognitive test battery. Compliance rate was high (6.7-10% missing values). Subjective burden was relatively low. Time-series data showed sufficient variability and no floor- or ceiling effects, except for one relevant ceiling effect on the One Back task. The personal feedback report was considered insightful by 4 out of 11 participants and 5 out of 7 clinicians. Daily assessments are suitable for a minority of cognitively impaired older persons, but is helpful to increase insight into their symptoms. [ABSTRACT FROM AUTHOR]

Published
2023
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47. The Frail Depressed Patient: A Narrative Review on Treatment Challenges

Author

Aprahamian,Ivan, Borges,Marcus K, Hanssen,Denise J.C., Jeuring,Hans W, and Oude Voshaar,Richard C.

Subjects
Clinical Interventions in Aging
Abstract

Ivan Aprahamian,1,2 Marcus K Borges,3 Denise J C Hanssen,2 Hans W Jeuring,2 Richard C Oude Voshaar2 1Group of Investigation on Multimorbidity and Mental Health in Aging (GIMMA), Geriatrics Division, Department of Internal Medicine, Jundiaí Medical School, Jundiaí, Brazil; 2University of Groningen, University Medical Center Groningen, Department of Psychiatry, Groningen, the Netherlands; 3Federal University of Paraná, Department of Psychiatry, Curitiba, BrazilCorrespondence: Ivan Aprahamian, Group of Investigation on Multimorbidity and Mental Health in Aging (GIMMA), Division of Geriatrics, Department of Internal Medicine, Jundiaí Medical School, Jundiaí, Brazil, Email ivan.aprahamian@gmail.comAbstract: Although the public importance of frailty is widely acknowledged by the World Health Organization, physical frailty is still largely neglected in geriatric mental health care. Firstly in this narrative review, we summarize the knowledge on the epidemiology of the association between depression and frailty, whereafter implications for treatment will be discussed. Even though frailty and depression have overlapping diagnostic criteria, epidemiological studies provide evidence for distinct constructs which are bidirectionally associated. Among depressed patients, frailty has predictive validity being associated with increased mortality rates and an exponentially higher fall risk due to antidepressants. Nonetheless, guidelines on the treatment of depression neither consider frailty for risk stratification nor for treatment selection. We argue that frailty assessment enables clinicians to better target the pharmacological and psychological treatment of depression as well as the need for interventions targeting primarily frailty, for instance, lifestyle interventions and reduction of polypharmacy. Applying a frailty informed framework of depression treatment studies included in a meta-analysis reveals that the benefit–harm ratio of antidepressants given to frail depressed patients can be questioned. Nonetheless, frail-depressed patients should not withhold antidepressants as formal studies are not available yet, but potential adverse effects should be closely monitored. Dopaminergic antidepressants might be preferable when slowness is a prominent clinical feature. Psychotherapy is an important alternative for pharmacological treatment, especially psychotherapeutic approaches within the movement of positive psychology, but this approach needs further study. Finally, geriatric rehabilitation, including physical exercise and nutritional advice, should also be considered. In this regard, targeting ageing-related abnormalities underlying frailty that may also be involved in late-life depression such as low-grade inflammation might be a promising target for future studies. The lack of treatment studies precludes firm recommendations, but more awareness for frailty in mental health care will open a plethora of alternative treatment options to be considered.Keywords: frailty, depression, depressive disorder

Published
2022

48. Huntingtin gene repeat size variations affect risk of lifetime depression

Author

Gardiner, Sarah L., van Belzen, Martine J., Boogaard, Merel W., van Roon-Mom, Willeke M. C., Rozing, Maarten P., van Hemert, Albert M., Smit, Johannes H., Beekman, Aartjan T. F., van Grootheest, Gerard, Schoevers, Robert A., Oude Voshaar, Richard C., Roos, Raymund A. C., Comijs, Hannie C., Penninx, Brenda W. J. H., van der Mast, Roos C., and Aziz, N. Ahmad

Published
2017
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