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18 results on '"Ouattara, Mahamoudou"'

1. Epidemiology of pneumococcal meningitis in sentinel hospital surveillance of Viet Nam, 2015–2018

Author

Nguyen, Dac Trung, Nguyen, Thi Loan, Olmsted, Allison, Duong, Thi Hong, Hoang, Hong Mai, Nguyen, Lien Huong, Ouattara, Mahamoudou, Milucky, Jennifer, Lessa, Fernanda C., Vo, Thi Trang Dai, Phan, Van Thanh, Nguyen, Thi Hien Anh, Pham, Nguyen My Nguyet, Truong, Huu Khanh, Phan, Thi Quynh Tram, Bui, Thi Hong Hoa, Pham, Van Khang, Iijima, Makiko, Le, Binh, Kim, Lindsay, and Farrar, Jennifer Loo

Published
2024
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2. Identification of Streptococcus suis Meningitis by Direct Triplex Real-Time PCR, Burkina Faso

Author

Ouattara, Mahamoudou, Tamboura, Mamadou, Kambire, Dinanibe, Sanou, Mahamoudou, Ouattara, Kalifa, Congo, Malika, Kabore, Adama, Sanou, Soufiane, Kabre, Elie, Sharpley, Sable, Tran, Theresa, Schwartz, Stephanie, Ouangraoua, Soumeya, Ouedraogo, Abdoul-salam, Sangare, Lassana, Ouedraogo-Traore, Rasmata, Whitney, Cynthia G., and Beall, Bernard

Subjects
Diseases, Pork, Resveratrol, Meningitis, Pneumonia, Endocarditis, Pork industry, Swine
Abstract

Streptococcus suis is a commensal organism of the upper respiratory tract of pigs that can occasionally cause severe invasive infections in these animals (1,2). The bacterium also can infect humans [...]

Published
2020
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8. Triplex Direct Quantitative Polymerase Chain Reaction for the Identification of Streptococcus pneumoniae Serotypes

Author

Ouattara, Mahamoudou, primary, Tamboura, Mamadou, additional, Kambiré, Dinanibè, additional, Lê, Kim Anh, additional, Van Phan, Thanh, additional, Velusamy, Srinivasan, additional, Nguyen, Hien Anh, additional, Trang, Dai Vo Thi, additional, Lessa, Fernanda C, additional, Iijima, Makiko, additional, Nguyen, Dac Trung, additional, Schwartz, Stephanie B, additional, McGee, Lesley, additional, Traoré, Rasmata Ouédraogo, additional, and Beall, Bernard, additional

Published
2021
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9. The Global Landscape of Pediatric Bacterial Meningitis Data Reported to the World Health Organization–Coordinated Invasive Bacterial Vaccine-Preventable Disease Surveillance Network, 2014–2019

Author

Nakamura, Tomoka, primary, Cohen, Adam L, additional, Schwartz, Stephanie, additional, Mwenda, Jason M, additional, Weldegebriel, Goitom, additional, Biey, Joseph N M, additional, Katsande, Reggis, additional, Ghoniem, Amany, additional, Fahmy, Kamal, additional, Rahman, Hossam Abdel, additional, Videbaek, Dovile, additional, Daniels, Danni, additional, Singh, Simarjit, additional, Wasley, Annemarie, additional, Rey-Benito, Gloria, additional, de Oliveira, Lucia, additional, Ortiz, Claudia, additional, Tondo, Emmanuel, additional, Liyanage, Jayantha B L, additional, Sharifuzzaman, Mohammad, additional, Grabovac, Varja, additional, Batmunkh, Nyambat, additional, Logronio, Josephine, additional, Heffelfinger, James, additional, Fox, Kimberly, additional, De Gouveia, Linda, additional, von Gottberg, Anne, additional, Du Plessis, Mignon, additional, Kwambana-Adams, Brenda, additional, Antonio, Martin, additional, El Gohary, Samaa, additional, Azmy, Aya, additional, Gamal, Asmaa, additional, Voropaeva, Elena, additional, Egorova, Ekaterina, additional, Urban, Yulia, additional, Duarte, Carolina, additional, Veeraraghavan, Balaji, additional, Saha, Samir, additional, Howden, Ben, additional, Sait, Michelle, additional, Jung, Sangoun, additional, Bae, Songmee, additional, Litt, David, additional, Seaton, Shila, additional, Slack, Mary, additional, Antoni, Sebastien, additional, Ouattara, Mahamoudou, additional, Van Beneden, Chris, additional, and Serhan, Fatima, additional

Published
2021
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12. Triplex real-time PCR assay for the detection of Streptococcus pneumoniae, Neisseria meningitidis and Haemophilus influenzae directly from clinical specimens without extraction of DNA

Author

Ouattara, Mahamoudou, primary, Whaley, Melissa J., additional, Jenkins, Laurel T., additional, Schwartz, Stephanie B., additional, Traoré, Rasmata Ouédraogo, additional, Diarra, Seydou, additional, Collard, Jean-Marc, additional, Sacchi, Claudio T., additional, and Wang, Xin, additional

Published
2019
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13. Continued occurrence of serotype 1 pneumococcal meningitis in two regions located in the meningitis belt in Ghana five years after introduction of 13-valent pneumococcal conjugate vaccine

Author

Bozio, Catherine H., primary, Abdul-Karim, Abass, additional, Abenyeri, John, additional, Abubakari, Braimah, additional, Ofosu, Winfred, additional, Zoya, Justina, additional, Ouattara, Mahamoudou, additional, Srinivasan, Velusamy, additional, Vuong, Jeni T., additional, Opare, David, additional, Asiedu-Bekoe, Franklin, additional, and Lessa, Fernanda C., additional

Published
2018
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14. Molecular Mechanism of Heme Acquisition and Degradation by the Human Pathogen Group A Streptococcus

Author

Ouattara, Mahamoudou

Abstract

Heme is the major iron source for the deadly human pathogen, Group A Streptococcus (GAS). During infection, GAS lyses host cells releasing hemoglobin and other hemoproteins. This dissertation aims to elucidate the general mechanism by which GAS obtains and utilizes heme as an iron source from the host hemoproteins. GAS encodes a heme relay system consisting of Shr, Shp and the SiaABC transporter. We specifically determine the role of Shr in the heme uptake process, by conducting a detailed functional characterization of its constituent domains. We also undertake to solve the long-standing mystery surrounding the catabolism of heme in streptococci. The studies presented herein established Shr as a prototype of a new family of NEAT-containing hemoproteins receptors. They demonstrate its importance in heme acquisition by GAS and provide a molecular model for heme scavenging and transfer by the protein. We show that Shr modulates heme uptake depending on heme availability by a mechanism where NEAT1 facilitates fast heme scavenging and delivery to Shp, whereas NEAT2 serves as a temporary storage for heme on the bacterial surface. Finally, we identified and characterized for the first time, a heme oxygenase (HO) in the Streptococcus genus which was named HupZ. Sequence comparison between HupZ and several HOs from different structural families indicates that this enzyme is unrelated to any of the previously characterized HOs. However, orthologs of the protein are found in other important pathogens. The structure and the catalytic mechanism of HupZ suggest that it is the representative of a new family of flavoenzymes capable of degrading heme using their reduced flavin cofactor as a source of electrons. Overall, this work contributes significant knowledge to the topic of heme utilization by pathogens and importantly, provides new direct evidence that associates flavins with heme metabolism in bacteria. Thus it sets a new direction in the field and lays the ground for future fundamental and applied discoveries.

Published
2013
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15. vanG Element Insertions within a Conserved Chromosomal Site Conferring Vancomycin Resistance to Streptococcus agalactiae and Streptococcus anginosus

Author

Srinivasan, Velusamy, primary, Metcalf, Benjamin J., additional, Knipe, Kristen M., additional, Ouattara, Mahamoudou, additional, McGee, Lesley, additional, Shewmaker, Patricia L., additional, Glennen, Anita, additional, Nichols, Megin, additional, Harris, Carol, additional, Brimmage, Mary, additional, Ostrowsky, Belinda, additional, Park, Connie J., additional, Schrag, Stephanie J., additional, Frace, Michael A., additional, Sammons, Scott A., additional, and Beall, Bernard, additional

Published
2014
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17. A Foreign Protein Incorporated on the Tip of T3 Pili in Lactococcus lactisElicits Systemic and Mucosal Immunity

Author

Quigley, Bernard R., Hatkoff, Matthew, Thanassi, David G., Ouattara, Mahamoudou, Eichenbaum, Zehava, and Scott, June R.

Abstract

ABSTRACTThe use of Lactococcus lactisto deliver a chosen antigen to the mucosal surface has been shown to elicit an immune response in mice and is a possible method of vaccination in humans. The recent discovery on Gram-positive bacteria of pili that are covalently attached to the bacterial surface and the elucidation of the residues linking the major and minor subunits of such pili suggests that the presentation of an antigen on the tip of pili external to the surface of L. lactismight constitute a successful vaccine strategy. As a proof of principle, we have fused a foreign protein (the Escherichia colimaltose-binding protein) to the C-terminal region of the native tip protein (Cpa) of the T3 pilus derived from Streptococcus pyogenesand expressed this fusion protein (MBP*) in L. lactis. We find that MBP* is incorporated into pili in this foreign host, as shown by Western blot analyses of cell wall proteins and by immunogold electron microscopy. Furthermore, since the MBP* on these pili retains its native biological activity, it appears to retain its native structure. Mucosal immunization of mice with this L. lactisstrain expressing pilus-linked MBP* results in production of both a systemic and a mucosal response (IgG and IgA antibodies) against the MBP antigen. We suggest that this type of mucosal vaccine delivery system, which we term UPTOP (for unhindered presentation on tips of pili), may provide an inexpensive and stable alternative to current mechanisms of immunization for many serious human pathogens.

Published
2010
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18. vanGElement Insertions within a Conserved Chromosomal Site Conferring Vancomycin Resistance to Streptococcus agalactiaeand Streptococcus anginosus

Author

Srinivasan, Velusamy, Metcalf, Benjamin J., Knipe, Kristen M., Ouattara, Mahamoudou, McGee, Lesley, Shewmaker, Patricia L., Glennen, Anita, Nichols, Megin, Harris, Carol, Brimmage, Mary, Ostrowsky, Belinda, Park, Connie J., Schrag, Stephanie J., Frace, Michael A., Sammons, Scott A., and Beall, Bernard

Abstract

ABSTRACTThree vancomycin-resistant streptococcal strains carrying vanGelements (two invasive Streptococcus agalactiaeisolates [GBS-NY and GBS-NM, both serotype II and multilocus sequence type 22] and one Streptococcus anginosus[Sa]) were examined. The 45,585-bp elements found within Sa and GBS-NY were nearly identical (together designated vanG-1) and shared near-identity over an ~15-kb overlap with a previously described vanGelement from Enterococcus faecalis. Unexpectedly, vanG-1shared much less homology with the 49,321-bp vanG-2element from GBS-NM, with widely different levels (50% to 99%) of sequence identity shared among 44 related open reading frames. Immediately adjacent to both vanG-1and vanG-2were 44,670-bp and 44,680-bp integrative conjugative element (ICE)-like sequences, designated ICE-r, that were nearly identical in the two group B streptococcal (GBS) strains. The dual vanGand ICE-r elements from both GBS strains were inserted at the same position, between bases 1328 and 1329, within the identical RNA methyltransferase (rumA) genes. A GenBank search revealed that although most GBS strains contained insertions within this specific site, only sequence type 22 (ST22) GBS strains contained highly related ICE-r derivatives. The vanG-1element in Sa was also inserted within this position corresponding to its rumAhomolog adjacent to an ICE-r derivative. vanG-1insertions were previously reported within the same relative position in the E. faecalis rumAhomolog. An ICE-r sequence perfectly conserved with respect to its counterpart in GBS-NY was apparent within the same site of the rumAhomolog of a Streptococcus dysgalactiaesubsp. equisimilisstrain. Additionally, homologous vanG-like elements within the conserved rumAtarget site were evident in Roseburia intestinalis.IMPORTANCEThese three streptococcal strains represent the first known vancomycin-resistant strains of their species. The collective observations made from these strains reveal a specific hot spot for insertional elements that is conserved between streptococci and different Gram-positive species. The two GBS strains potentially represent a GBS lineage that is predisposed to insertion of vanGelements.

Published
2014
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