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3. Risk factors for severe morbidity and definitive stoma after elective surgery for sigmoid diverticulitis: a multicenter national cohort study

Author

Sabbagh, C., Beyer-Berjot, L., Ouaissi, M., Zerbib, P., Bridoux, V., Manceau, G., Karoui, M., Panis, Y., Buscail, E., Venara, A., Khaoudy, I., Gaillard, M., Ortega-Deballon, P., Viennet, M., Thobie, A., Menahem, B., Eveno, C., Bonnel, C., Mabrut, J.-Y., Badic, B., Godet, C., Eid, Y., Duchalais, E., Lakkis, Z., Cotte, E., Laforest, A., Defourneaux, V., Maggiorri, L., Rebibo, L., Christou, N., Talal, A., Mege, D., Bonnamy, C., Germain, A., Mauvais, F., Tresallet, C., Ahmed, O., Regimbeau, J.-M., Roudie, J., Laurent, A., Trilling, B., Bertrand, M., Massalou, D., Romain, B., Tranchart, H., Giger, U., Dejardin, O., Pellegrin, A., and Alves, A.

Published
2024
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4. High infection rates of Triatoma dimidiata are associated with low levels of Trypanosoma cruzi seroprevalence in Pedro Carbo, Ecuador. Use of a tc24 gene-based PCR approach

Author

Guevara A.G., Garzón E., Bowen C., Córdova X., Gómez E., and Ouaissi A.

Subjects
Chagas’ disease, Trypanosoma cruzi, Triatoma dimidiata, vectorial capacity, polymerase chain reaction, Ecuador, Infectious and parasitic diseases, RC109-216
Abstract

In control programs for vectorial transmission of Chagas’ disease, conventional microscopic procedures are generally performed to determine baseline levels of infectivity of vectors. Reported here are data using Polymerase Chain Reaction in the detection of Trypanosoma cruzi in Triatoma dimidiata, one of the principal vectors of Chagas’ disease in Ecuador. The microscopy and PCR techniques showed a high percentage of vector infection in Pedro Carbo, province of Guayas (Ecuador), with 44.16 % and 46.13 % positive insects, respectively. This contrasted with the very low Chagas seropositivity recorded (0.5 %). Since T. dimidiata was the only vector of the Chagas’ disease found in Pedro Carbo and looking at the vector behavior, our data suggest that despite the high T. dimidiata infection, the low Chagas seropositivity detected is closely associated with the epidemiological and ecological context of T. dimidiata in Pedro Carbo.

Published
2005
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5. Preliminary results of random amplification of polymorphic DNA among Triatominae of the phyllosoma complex (Hemiptera, Reduviidae)

Author

Brenière Simone F, Taveira Bruno, Bosseno, Ordoñez Rosalinda, Lozano-Kasten Felipe, Magallón-Gastélum Ezequiel, Ouaissi Ali, and Ramsey Janine

Subjects
Triatominae, phyllosoma complex, random amplification of polymorphic DNA, phylogeny, Mexico, Microbiology, QR1-502, Infectious and parasitic diseases, RC109-216
Abstract

In Mexico, Triatoma longipennis (Usinger), Triatoma picturata (Usinger), and Triatoma pallidipennis (Stal), primary Chagas disease vector species of the phyllosoma complex, were analyzed by randomly amplified polymorphic DNA (RAPD). Sixteen decametric primers resolved individual profiles not identical, but partially discriminative between species. Analysis based on pairwise presence/absence comparisons between the three species was performed using three primers and two outgroup species Triatoma infestans (Klug) and Triatoma barberi (Usinger). Fifty-three bands in total were scored, although only two bands were constant among the three phyllosoma complex species. Two other bands were constant only for T. longipennis and T. picturata together, and not present in T. pallidipennis. Neighbor Joining tree and the multiple correspondence analysis discriminated T. pallidipennis clearly from the other two species, although there was overlap between T. longipennis and T. picturata. The results indicate a close relationship between the studied species and support the hypothesis of their recent evolution. The suitability of RAPD to discern populations within the species is discussed.

Published
2003

6. Severe postoperative morbidity after left colectomy for sigmoid diverticulitis without splenic flexure mobilization. Results of a multicenter cohort study with propensity score analysis

Author

Barraud, Alexis, Sabbagh, Charles, Beyer-Berjot, Laura, Ouaissi, Mehdi, Zerbib, Philippe, Bridoux, Valérie, Manceau, Gilles, Panis, Yves, Buscail, Etienne, Venara, Aurélien, Khaoudy, Iman, Gaillard, Martin, Viennet, Manon, Thobie, Alexandre, Menahem, Benjamin, Eveno, Clarisse, Bonnel, Catherine, Mabrut, Jean-Yves, Badic, Bogdan, Godet, Camille, Eid, Yassine, Duchalais, Emilie, Lakkis, Zaher, Cotte, Eddy, Laforest, Anaïs, Defourneaux, Véronique, Maggiori, Léon, Rebibo, Lionel, Christou, Niki, Talal, Ali, Mege, Diane, Bonnamy, Cécile, Germain, Adeline, Mauvais, François, Tresallet, Christophe, Roudie, Jean, Laurent, Alexis, Trilling, Bertrand, Bertrand, Martin, Massalou, Damien, Romain, Benoit, Tranchart, Hadrien, Pellegrin, Alexandra, Briant, Anais R., Parienti, Jean Jacques, and Alves, Arnaud

Published
2024
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8. Risk factors for emergency surgery for diverticulitis: A retrospective multicentric French study at 41 hospitals

Author

Jeanne, Dembinski, Gillet, Julien, Hamy, Antoine, Lahmidi, Amine, Sebbagh, Mohamed, Bres, Antoine, Girard, Nicolas, Desjouis, Aurélie, Ainseba, Nadjib, Epailly, Julien, Huysman, Fabienne, Dezeustre, Maud, Doussot, Alexandre, Turco, Célia, Bourrhis, Diane, Godet, Camille, Finocchi, Morgane, Marion, Yoan, Lebreton, Gil, Benard, Flavie, Pineau, Elodie, Bouvier, Véronique, Ortega-Deballon, Pablo, Moreno-Lopez, Nathan, Rat, Patrick, Makar, Bassem, Fara, Paola, Pompilio, Marc, Hertault, Hugo, Guezennec, Corentin, Saida, Habchi, Brinza, Alexandre, Plard, Laurent, Ailhaud, Antoine, Gutierrez, Léa, Venchiarutti, Vincent, Faucheron, Jean-Luc, Morin, Bertrand, Pech de la Clause, Bertrand, Voitellier, Eglantine, Gagnat, Guillaume, Noiret, Barbara, Laroye, Constance, Piessen, Guillaume, Lécolle, Katia, Robert, Jean, Nzamushelepanmabla, Engel, Perrine, Mathonnet, Muriel, Rodriguez, Cyprien, Makki, Ammar, Couchard, Anne-Cécile, Duramé, François, Marceau, Cécile, Paquet, Jean-Christophe, Kepenekian, Vahan, Passot, Guillaume, Glehen ; Ninon Wallach, Olivier, Mohkam, Kayvan, Blanc, Marie-Caroline, Berdah, Stéphane, Aubert, Mathilde, Ayav, Ahmet, Chanty, Hervé, Didier, Alexandre, Vigneron, Estelle, Périard, Noémie, Thaumoux, Marie, Grenouilloux, Océane, Fall, Seila, Thomareis, Sophoclis, Marsollier, Chloé, Prud’homme, Michel, Antonopulos, Christos, Msika, Simon, Monsinjon, Marie, Giacca, Massimo, Cazelles, Antoine, Karoui, Mehdi, Malerba, Valentina, Dagher, Ibrahim, de Angelis, Nicola, Brunetti, Francesco, Ahmed, Omar, Ferraz, Jean-Marc, Ramjaun, Yassir, Denet, Christine, Fuchs, Basile, Pietrasz, Daniel, Raimbert, Pénélope, Benedetti, Juliette, Coton, Chloé, Corte, Hélène, Medrignac, Aude, Chavrier, Daphné, Girard, Robin, Berthelot, Julia, Monge, Matthieu, Papet, Eloïse, Pinson, Jean, Dolbeau, Elise, Tuech, Jean-Jacques, Chautard, Julien, Boullier, Mathilde, Goujard, François, Perrot, Laurent, Loge, Ludovic, Petiot, Jean-Michel, Manfredelli, Simone, Charleux-Muller, Diane, Sauvinet, Guillaume, Bertin, Jean-Baptiste, Vincent, Louis, Simeu, Blandine, Delhorme, Jean-Baptiste, Brigand, Cécile, Rohr, Serge, Bouchet, Manon, Duffas, Jean-Pierre, Ghouti, Laurent, Philis, Antoine, Portier, Guillaume, Karam, Elias, Michot, Nicolas, Artus, Alice, Mauny, Emilien, Bourbao-Tournois, Céline, Barbin, Hugo, Thiery, Julien, Sabbagh, Charles, Beyer-Berjot, Laura, Ouaissi, Mehdi, Zerbib, Philippe, Valérie, Bridoux, Manceau, Gilles, Panis, Yves, Buscail, Etienne, Venara, Aurélien, Khaoudy, Iman, Gaillard, Martin, Viennet, Manon, Thobie, Alexandre, Menahem, Benjamin, Eveno, Clarisse, Bonnel, Catherine, Mabrut, Jean-Yves, Badic, Bogdan, Eid, Yassine, Duchalais, Emilie, Lakkis, Zaher, Cotte, Eddy, Laforest, Anaïs, Desfourneaux-Denis, Véronique, Maggiori, Léon, Rebibo, Lionel, Niki, Christou, Talal, Ali, Mege, Diane, Bonnamy, Cécile, Germain, Adeline, Mauvais, François, Tresallet, Christophe, Roudie, Jean, Laurent, Alexis, Trilling, Bertrand, Bertrand, Martin, Massalou, Damien, Romain, Benoit, Tranchart, Hadrien, Pellegrin, Alexandra, Dejardin, Olivier, and Alves, Arnaud

Published
2024
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9. Impact of the first wave of COVID-19 epidemy on the surgical management of sigmoid diverticular disease in France: National French retrospective study

Author

Gil, Camille, Beyer-Bergeot, Laura, Sabbagh, Charles, Zerbib, Philippe, Bridoux, Valérie, Manceau, Gilles, Panis, Yves, Buscail, Etienne, Venara, Aurélien, Khaoudy, Iman, Gaillard, Martin, Viennet, Manon, Thobie, Alexandre, Menahem, Benjamin, Eveno, Clarisse, Bonnel, Catherine, Mabrut, Jean-Yves, Badic, Bodgan, Godet, Camille, Eid, Yassine, Duchalais, Emilie, Lakkis, Zaher, Cotte, Eddy, Laforest, Anais, Defourneaux, Véronique, Maggiori, Léon, Rebibo, Lionel, Christou, Niki, Talal, Ali, Mege, Diane, Bonnamy, Cécile, Germain, Adeline, Mauvais, François, Tresallet, Christophe, Roudie, Jean, Laurent, Alexis, Trilling, Bertrand, Bertrand, Martin, Massalou, Damien, Romain, Benoit, Tranchart, Hadrien, Giger, Urs, Alves, Arnaud, and Ouaissi, Mehdi

Published
2023
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11. The Angers CT Score is a Risk Factor for the Failure of the Conservative Management of Adhesive Small Bowel Obstruction: A Prospective Observational Multicentric Study

Author

Paisant, Anita, Burgmaier, Jeanne, Calame, Paul, Loison, Mélanie, Molière, Sébastien, Brigand, Cécile, Belabbas, Dihia, Duchalais, Emilie, Regimbeau, Jean-Marc, Yzet, Thierry, Alves, Arnaud, Fohlen, Audrey, Bergeat, Damien, Vauclair, Estelle, Pellegrini, Julie, Ragot, Emilia, Lansier, Alexandre, Abet, Emeric, Nevot, Alexandre, Rousset, Pascal, Ouaissi, Mehdi, Besson, Marie, Ronot, Maxime, Giacca, Massimo, Girard, Edouard, Tessier, Yann, Massalou, Damien, Poirier, Florent, Lakkis, Zaher, Aubé, Christophe, Hamel, Jean Francois, Passot, Guillaume, and Venara, Aurélien

Published
2023
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13. Performance of different nebulizers in clinical use for Pressurized Intraperitoneal Aerosol Chemotherapy (PIPAC).

Author

Daniel Göhler, Kathrin Oelschlägel, Mehdi Ouaissi, and Urs Giger-Pabst

Subjects
Medicine, Science
Abstract

ObjectiveTechnical ex-vivo comparison of commercial nebulizer nozzles used for Pressurized Intraperitoneal Aerosol Chemotherapy (PIPAC).MethodsThe performance of four different commercial nebulizer nozzles (Nebulizer; HurriChemTM; MCR-4 TOPOL®; QuattroJet) was analysed concerning: i) technical design and principle of operation, ii) operational pressure as function of the liquid flow rate, iii) droplet size distribution via laser diffraction spectrometry, iv) spray cone angle, spray cone form as well as horizontal drug deposition by image-metric analyses and v) chemical resistance via exposing to a cytostatic solution and chemical composition by means of spark optical emission spectral analysis.ResultsThe Nebulizer shows quasi an identical technical design and thus also a similar performance (e.g., mass median droplet size of 29 μm) as the original PIPAC nozzles (MIP/ CapnoPen). All other nozzles show more or less a performance deviation to the original PIPAC nozzles. The HurriChemTM has a similar design and principle of operation as the Nebulizer, but provides a finer aerosol (22 μm). The principle of operation of MCR-4 TOPOL® and QuattroJet differ significantly from that of the original PIPAC nozzle technology. The MCR-4 TOPOL® offers a hollow spray cone with significantly larger droplets (50 μm) than the original PIPAC nozzles. The QuattroJet generates an aerosol (22 μm) similar to that of the HurriChemTM but with improved spatial drug distribution.ConclusionThe availability of new PIPAC nozzles is encouraging but can also have a negative impact if their performance and efficacy is unknown. It is recommended that PIPAC nozzles that deviate from the current standard should be subject to bioequivalence testing and implementation in accordance with the IDEAL-D framework prior to routine clinical use.

Published
2024
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14. Is Delaying a Coloanal Anastomosis the Ideal Solution for Rectal Surgery?: Analysis of a Multicentric Cohort of 564 Patients From the GRECCAR

Author

Collard, Maxime K., Rullier, Eric, Tuech, Jean-Jacques, Sabbagh, Charles, Souadka, Amine, Loriau, Jérome, Faucheron, Jean-Luc, Benoist, Stéphane, Dubois, Anne, Dumont, Frédéric, Germain, Adeline, Manceau, Gilles, Marchal, Frédéric, Sourrouille, Isabelle, Lakkis, Zaher, Lelong, Bernard, Derieux, Simon, Piessen, Guillaume, Laforest, Anaïs, Venara, Aurélien, Prudhomme, Michel, Brigand, Cécile, Duchalais, Emilie, Ouaissi, Mehdi, Lebreton, Gil, Rouanet, Philippe, Mège, Diane, Pautrat, Karine, Reynolds, Ian S., Pocard, Marc, Parc, Yann, Denost, Quentin, and Lefevre, Jérémie H.

Published
2023
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17. Prognostic value of primary tumor sidedness in patients with non-metastatic IBD related CRC – Is it the exception to the rule?

Author

Kamphues, Carsten, Lefevre, Jeremie H., Wang, Jane, Amini, Neda, Beaugerie, Laurent, Kuehn, Florian, Park, Sang Hyoung, Andreatos, Nikolaos, Lauscher, Johannes C., Enea, Diana, Lehmann, Kai S., Peru, Nicolas, Weixler, Benjamin, Kirchgesner, Julien, Degro, Claudius E., Pozios, Ioannis, van Beekum, Cornelius J., Schölch, Sebastian, Zambonin, Daniela, Schineis, Christian, Loch, Florian N., Geka, Despoina, Theoxari, Maria, Wu, Bin, Wang, Pei-Pei, Antoniou, Efstathios, Pikoulis, Emmanouil, Moussata, Driffa, Theodoropoulos, George, Ouaissi, Mehdi, Seeliger, Hendrik, Inaba, Yosuke, Scaringi, Stefano, Reißfelder, Christoph, Vilz, Tim O., Lin, Chen, Yang, Suk-Kyun, Beyer, Katharina, Renz, Bernhard W., Sasaki, Kazunari, Margonis, Georgios Antonios, Svrcek, Magali, and Kreis, Martin E.

Published
2022
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18. Role of protective stoma after primary anastomosis for generalized peritonitis due to perforated diverticulitis—DIVERTI 2 (a prospective multicenter randomized trial): rationale and design (nct04604730)

Author

Jean Pinson, Jean-Jacques Tuech, Mehdi Ouaissi, Murielle Mathonnet, François Mauvais, Estelle Houivet, Elie Lacroix, Julie Rondeaux, Charles Sabbagh, and Valérie Bridoux

Subjects
Ileostomy, Perforated diverticulitis, Hartmann’s procedure, Rectosigmoid resection, Peritonitis, Primary anastomosis, Surgery, RD1-811
Abstract

Abstract Background Traditionally, patients with peritonitis Hinchey III and IV due to perforated diverticulitis were treated with Hartmann’s procedure. In the past decade, resection and primary anastomosis have gained popularity over Hartmann’s procedure and recent guidelines recommend Hartmann’s procedure in two situations only: critically ill patients and in selected patients with multiple comorbidity (at high risk of complications). The protective stoma (PS) is recommended after resection with primary anastomosis, however its interest has never been studied. The aim of this trial is to define the role of systematic PS after resection and primary anastomosis for peritonitis Hinchey III and IV due to perforated diverticulitis. Methods/design This DIVERTI 2 trial is a multicenter, randomized, controlled, superiority trial comparing resection and primary anastomosis with (control group) or without (experimental group) PS in patients with peritonitis Hinchey III and IV due to perforated diverticulitis. Primary endpoint is the overall 1 year morbidity according to the Clavien–Dindo classification of surgical complications. All complications occurring during hospitalization will be collected. Late complications occurring after hospitalization will be collected during follow-up. In order to obtain 80% power for a difference given by respective main probabilities of 67% and 47% in the protective stoma and no protective stoma groups respectively, with a two-sided type I error of 5%, 96 patients will have to be included in each group, hence 192 patients overall. Expecting a 5% rate of patients not assessable for the primary end point (lost to follow-up), 204 patients will be enrolled. Secondary endpoints are postoperative mortality, unplanned reinterventions, incisional surgical site infection (SSI), organ/space SSI, wound disruption, anastomotic leak, operating time, length of hospital stay, stoma at 1 year after initial surgery, quality of life, costs and quality-adjusted life years (QALYs). Discussion The DIVERTI 2 trial is a prospective, multicenter, randomized, study to define the best strategy between PS and no PS in resection and primary anastomosis for patients presenting with peritonitis due to perforated diverticulitis. Trial registration ClinicalTrial.gov: NCT04604730 date of registration October 27, 2020. https://clinicaltrials.gov/ct2/show/NCT04604730?recrs=a&cond=Diverticulitis&draw=2&rank=12 .

Published
2022
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19. Development and technical validation of an ultrasound nebulizer to deliver intraperitoneal pressurized aerosols in a rat colon cancer peritoneal metastases model

Author

Jonathan R. Buggisch, Daniel Göhler, Julien Sobilo, Stéphanie Lerondel, Günther A. Rezniczek, Michael Stintz, Andreas Rudolph, Nicolas Tabchouri, Sébastien Roger, Mehdi Ouaissi, and Urs Giger-Pabst

Subjects
Peritoneal metastasis, Human colorectal cancer cells, Orthotopic rat model, Ultrasonic nebulizer, Intraperitoneal pressurized aerosol, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract

Abstract Background/aim To develop and validate a nebulizer device for anti-cancer research on pressurized intraperitoneal aerosol supply in a preclinical peritoneal metastases (PM) rat model. Material and methods For aerosol generation, an ultrasonic nebulizer (USN) was modified. Aerosol analyses were performed ex-vivo by laser diffraction spectrometry (LDS). Intraperitoneal (IP) 99mtechnetium sodium pertechnetate (99mTc) aerosol distribution and deposition were quantified by in-vivo single photon emission computed tomography (SPECT/CT) and compared to liquid IP instillation of equivalent volume/doses of 99mTc with and without capnoperitoneum. PM was induced by IP injection of HCT116-Luc2 human colon cancer cells in immunosuppressed RNU rats. Tumor growth was monitored by bioluminescence imaging (BLI), 18F-FDG positron emission tomography (PET) and tissues examination at necropsy. Results The USN was able to establish a stable and reproducible capnoperitoneum at a pressure of 8 to 10 mmHg. LDS showed that the USN provides a polydisperse and monomodal aerosol with a volume-weighted diameter of 2.6 μm. At a CO2 flow rate of 2 L/min with an IP residence time of 3.9 s, the highest drug deposition efficiency was found to be 15 wt.-%. In comparison to liquid instillation, nebulization showed the most homogeneous IP spatial drug deposition. Compared to BLI, 18F-FDG-PET was more sensitive to detect smaller PM nodules measuring only 1–2 mm in diameter. BLI, 18F-FDG PET and necropsy analyses showed relevant PM in all animals. Conclusions The USN together with the PM rat model are suitable for robust and species-specific preclinical pharmacological studies regarding intraperitoneal delivery of pressurized aerosolized drugs and cancer research.

Published
2022
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31. Severe Optic Neuropathy Induced by Very Prolonged Tedizolid as Suppressive Therapy: Description of a Case Report and Implication for Better Assessment.

Author

Coustilleres, F, Thillard, E M, Khanna, R K, Olivereau, S, Ouaissi, M, Pansu, N, and Lez, M L Le

Subjects
VASCULAR grafts, OXAZOLIDINONES, LINEZOLID, MEDICAL screening, NEUROPATHY
Abstract

The long-term tolerability of linezolid is low because of mitochondrial toxicity, whereas tedizolid may represent a better option for suppressive therapy. We report a first presumed case of tedizolid-associated optic neuropathy after a very prolonged (18-month) intake and believe that screening for optic neuropathy should be considered for patients undergoing tedizolid suppression. [ABSTRACT FROM AUTHOR]

Published
2024
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34. Curcumin and NCLX inhibitors share anti-tumoral mechanisms in microsatellite-instability-driven colorectal cancer

Author

Guéguinou, Maxime, Ibrahim, Sajida, Bourgeais, Jérôme, Robert, Alison, Pathak, Trayambak, Zhang, Xuexin, Crottès, David, Dupuy, Jacques, Ternant, David, Monbet, Valérie, Guibon, Roseline, Flores-Romero, Hector, Lefèvre, Antoine, Lerondel, Stéphanie, Le Pape, Alain, Dumas, Jean-François, Frank, Philippe G., Girault, Alban, Chautard, Romain, Guéraud, Françoise, García-Sáez, Ana J., Ouaissi, Mehdi, Emond, Patrick, Sire, Olivier, Hérault, Olivier, Fromont-Hankard, Gaëlle, Vandier, Christophe, Tougeron, David, Trebak, Mohamed, Raoul, William, and Lecomte, Thierry

Published
2022
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37. Advanced colonic cancer with clinically suspected bladder invasion: Outcomes and prognosis from a multicentric study of 117 patients from the FRENCH research group

Author

Arfa, Sara, Dumont, Paul-Noël, Boullenois, Hortense, Fuks, David, Ouaissi, Mehdi, Benhaim, Leonor, Selvy, Marie, Tuech, Jean-Jacques, Lakkis, Zaher, Lupinacci, Renato, Epin, Antoine, Deguelte, Sophie, Passot, Guillaume, Trilling, Bertrand, Jarlot-Gas, Cécile, Mathonnet, Muriel, Moszkowicz, David, M’Harzi, Leila, Beyer Berjot, Laura, Vuillermet, Cindy, Meillat, Hélène, Manceau, Gilles, Creavin, Ben, Eveno, Clarisse, Benoist, Stéphane, Parc, Yann, and Lefevre, Jérémie H.

Published
2020
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38. Risk factors for emergency surgery for diverticulitis: A retrospective multicentric French study at 41 hospitals.

Author

Godet, Camille, Sabbagh, Charles, Beyer-Berjot, Laura, Ouaissi, Mehdi, Zerbib, Philippe, Valérie, Bridoux, Manceau, Gilles, Panis, Yves, Buscail, Etienne, Venara, Aurélien, Khaoudy, Iman, Gaillard, Martin, Viennet, Manon, Thobie, Alexandre, Menahem, Benjamin, Eveno, Clarisse, Bonnel, Catherine, Mabrut, Jean-Yves, Badic, Bogdan, and Chautard, Julien

Abstract

The observed increase in the incidence of complicated diverticulitis may lead to the performance of more emergency surgeries. This study aimed to assess the rate and risk factors of emergency surgery for sigmoid diverticulitis. The primary outcomes were the rate of emergency surgery for sigmoid diverticulitis and its associated risk factors. The urgent or elective nature of the surgical intervention was provided by the surgeon and in accordance with the indication for surgical treatment. A mixed logistic regression with a random intercept after multiple imputations by the chained equation was performed to consider the influence of missing data on the results. Between 2010 and 2021, 6,867 patients underwent surgery for sigmoid diverticulitis in the participating centers, of which one-third (n = 2317) were emergency cases. In multivariate regression analysis with multiple imputation by chained equation, increasing age, body mass index <18.5 kg/m2, neurologic and pulmonary comorbidities, use of anticoagulant drugs, immunocompromised status, and first attack of sigmoid diverticulitis were independent risk factors for emergency surgery. The likelihood of emergency surgery was significantly more frequent after national guidelines, which were implemented in 2017, only in patients with a history of sigmoid diverticulitis attacks. The present study highlights a high rate (33%) of emergency surgery for sigmoid diverticulitis in France, which was significantly associated with patient features and the first attack of diverticulitis. [ABSTRACT FROM AUTHOR]

Published
2024
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39. Performance of different nebulizers in clinical use for Pressurized Intraperitoneal Aerosol Chemotherapy (PIPAC).

Author

Göhler, Daniel, Oelschlägel, Kathrin, Ouaissi, Mehdi, and Giger-Pabst, Urs

Subjects
NEBULIZERS & vaporizers, AEROSOLS, LASER deposition, CHEMICAL resistance, NOZZLES, CANCER chemotherapy
Abstract

Objective: Technical ex-vivo comparison of commercial nebulizer nozzles used for Pressurized Intraperitoneal Aerosol Chemotherapy (PIPAC). Methods: The performance of four different commercial nebulizer nozzles (Nebulizer; HurriChemTM; MCR-4 TOPOL®; QuattroJet) was analysed concerning: i) technical design and principle of operation, ii) operational pressure as function of the liquid flow rate, iii) droplet size distribution via laser diffraction spectrometry, iv) spray cone angle, spray cone form as well as horizontal drug deposition by image-metric analyses and v) chemical resistance via exposing to a cytostatic solution and chemical composition by means of spark optical emission spectral analysis. Results: The Nebulizer shows quasi an identical technical design and thus also a similar performance (e.g., mass median droplet size of 29 μm) as the original PIPAC nozzles (MIP/ CapnoPen). All other nozzles show more or less a performance deviation to the original PIPAC nozzles. The HurriChemTM has a similar design and principle of operation as the Nebulizer, but provides a finer aerosol (22 μm). The principle of operation of MCR-4 TOPOL® and QuattroJet differ significantly from that of the original PIPAC nozzle technology. The MCR-4 TOPOL® offers a hollow spray cone with significantly larger droplets (50 μm) than the original PIPAC nozzles. The QuattroJet generates an aerosol (22 μm) similar to that of the HurriChemTM but with improved spatial drug distribution. Conclusion: The availability of new PIPAC nozzles is encouraging but can also have a negative impact if their performance and efficacy is unknown. It is recommended that PIPAC nozzles that deviate from the current standard should be subject to bioequivalence testing and implementation in accordance with the IDEAL-D framework prior to routine clinical use. [ABSTRACT FROM AUTHOR]

Published
2024
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41. Chemical/technical risk analysis of a new multi-directional nebulizer (MDN) and its clinical implementation for the safe administration of Pressurized Intraperitoneal Aerosol Chemotherapy (MDN-PIPAC)

Author

Kockelmann, Fabian, primary, Göhler, Daniel, additional, Barbey, Sarah, additional, Gena, Amayu Wakoya, additional, Alsaad, Hayder, additional, Voelker, Conrad, additional, Zieren, Jürgen, additional, Ouaissi, Mehdi, additional, and Giger-Pabst, Urs, additional

Published
2023
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50. Surgical management of obstructive right-sided colon cancer at a national level results of a multicenter study of the French Surgical Association in 776 patients

Author

Berger, Anne, Ouaissi, Mehdi, Codjia, Tatiana, Dazza, Marie, Gagnat, Guillaume, Hamel, Servane, Mallet, Laure, Martre, Paul, Philouze, Guillaume, Roussel, Edouard, Tortajada, Pauline, Dumaine, Anne Stéphanie, Heyd, Bruno, Lakkis, Zaher, Paquette, Brice, de' Angelis, Nicola, Esposito, Francesco, Lizzi, Vincenzo, Michot, Nicolas, Denost, Quentin, Tresallet, Christophe, Tetard, Oriana, Sabbagh, Charles, Rivier, Pauline, Fayssal, Elie, Collard, Maxime, Moszkowicz, David, Peschaud, Frederique, Etienne, Jean Charles, loge, Ludovic, Beyer-Berjot, Laura, Bege, Thierry, Corte, Hélène, Bonnet, Julien, D'Annunzio, Elsa, Humeau, Marine, Issard, Julien, Munoz, Nicolas, Abba, Julio, Jafar, Yaqoub, Lacaze, Laurence, Sage, Pierre Yves, Susoko, Lilija, Trilling, Bertrand, Arvieux, Catherine, Mauvais, François, Severino, Béatrice Ulloa, Pitel, Sophie, Vauchaussade de Chaumont, Arthus, Badic, Bogdan, Blanc, Benjamin, Bert, Marine, Rat, Paul, Ortega-Deballon, Pablo, Chau, Amélie, Dejeante, Clémentine, Mariette, Christophe, Piessen, Guillaume, Grégoire, Emilie, Alfarai, Abdallah, Lefèvre, Jérémie, Cabau, Magali, David, Anaelle, Kadoche, Deborah, Dufour, Fanny, Goin, Géraldine, Goudard, Yvain, Pauleau, Ghislain, Sockeel, Philippe, De la Villeon, Bruno, Pautrat, Karine, Eveno, Clarisse, Brouquet, Antoine, Couchard, Anne Cécile, Balbo, Gregoire, Mabrut, Jean Yves, Bellinger, Justine, Bertrand, Martin, Aumont, Aurélie, Duchalais, Emilie, Messière Adrien Tranchart, Anne-Sophie, Cazauran, Jean-Baptiste, Pichot-Delahaye, Virginie, Dubuisson, Vincent, Maggiori, Leon, Boumediene, Bilem Djawad, Fuks, David, Kahn, Xavier, Huart, Eve, Catheline, Jean Marc, Lailler, Grégory, Baraket, Oussama, Baque, Patrick, Diaz de Cerio, Jean Marie, Bernard Maes, Philippe Mariol, Fernoux, Philippe, Guillem, Philippe, Chatelain, Eric, de Saint Roman, Charlotte, Fixot, Kévin, Mege, Diane, Manceau, Gilles, Bridoux, Valérie, Venara, Aurélien, Voron, Thibault, Brunetti, Francesco, Sielezneff, Igor, and Karoui, Mehdi

Published
2018
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