10 results on '"Ouédraogo, Espérance"'
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2. Assessment of Recovery Time, Worsening, and Death among Inpatients and Outpatients with COVID-19, Treated with Hydroxychloroquine or Chloroquine plus Azithromycin Combination in Burkina Faso
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Rouamba, Toussaint, Ouédraogo, Esperance, Barry, Houreratou, Yaméogo, Nobila Valentin, Sondo, Apoline, Boly, Rainatou, Zoungrana, Jacques, Ouédraogo, Abdoul Risgou, Tahita, Marc Christian, Poda, Armel, Diendéré, Arnaud Eric, Ouedraogo, Abdoul-Salam, Valea, Innocent, Traoré, Isidore, Tarnagda, Zekiba, Drabo, Maxime K, and Tinto, Halidou
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- 2022
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3. Safety of Chloroquine or Hydroxychloroquine Plus Azithromycin for the Treatment of COVID-19 Patients in Burkina Faso: An Observational Prospective Cohort Study
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Rouamba, Toussaint, primary, Barry, Houreratou, additional, Ouédraogo, Espérance, additional, Tahita, Marc Christian, additional, Yaméogo, Nobila Valentin, additional, Poda, Armel, additional, Diendéré, Eric Arnaud, additional, Ouedraogo, Abdoul-Salam, additional, Valea, Innocent, additional, Koné, Amariane M, additional, Thiombiano, Cherileila, additional, Traoré, Isidore, additional, Tarnagda, Zekiba, additional, Sawadogo, Serge Aimé, additional, Gansané, Zakaria, additional, Kambiré, Yibar, additional, Sanou, Idrissa, additional, Barro-Traoré, Fatou, additional, Drabo, Maxime K, additional, and Tinto, Halidou, additional
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- 2021
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4. Seasonal performance of a malaria rapid diagnosis test at community health clinics in a malaria-hyperendemic region of Burkina Faso
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Diarra Amidou, Nébié Issa, Tiono Alfred, Sanon Souleymane, Soulama Issiaka, Ouédraogo Alphonse, Gansané Adama, Yaro Jean B, Ouédraogo Espérance, Traoré Alfred S, and Sirima Sodiomon B
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Malaria diagnosis ,Transmission season ,RDT ,OptiMAL ,Infectious and parasitic diseases ,RC109-216 - Abstract
Abstract Backgound Treatment of confirmed malaria patients with Artemisinin-based Combination Therapy (ACT) at remote areas is the goal of many anti-malaria programs. Introduction of effective and affordable malaria Rapid Diagnosis Test (RDT) in remote areas could be an alternative tool for malaria case management. This study aimed to assess performance of the OptiMAL dipstick for rapid malaria diagnosis in children under five. Methods Malaria symptomatic and asymptomatic children were recruited in a passive manner in two community clinics (CCs). Malaria diagnosis by microscopy and RDT were performed. Performance of the tests was determined. Results RDT showed similar ability (61.2%) to accurately diagnose malaria as microscopy (61.1%). OptiMAL showed a high level of sensitivity and specificity, compared with microscopy, during both transmission seasons (high & low), with a sensitivity of 92.9% vs. 74.9% and a specificity of 77.2% vs. 87.5%. Conclusion By improving the performance of the test through accurate and continuous quality control of the device in the field, OptiMAL could be suitable for use at CCs for the management and control of malaria.
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- 2012
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5. Haemoglobin variants and Plasmodium falciparum malaria in children under five years of age living in a high and seasonal malaria transmission area of Burkina Faso
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Bougouma Edith C, Tiono Alfred B, Ouédraogo Alphonse, Soulama Issiaka, Diarra Amidou, Yaro Jean-Baptiste, Ouédraogo Espérance, Sanon Souleymane, Konaté Amadou T, Nébié Issa, Watson Nora L, Sanza Megan, Dube Tina JT, and Sirima Sodiomon B
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Plasmodium falciparum ,Malaria ,Haemoglobin abnormalities ,Children ,Epidemiology ,Burkina Faso ,Arctic medicine. Tropical medicine ,RC955-962 ,Infectious and parasitic diseases ,RC109-216 - Abstract
Abstract Background Genetic factors play a key role in determining resistance/susceptibility to infectious disease. Susceptibility of the human host to malaria infection has been reported to be influenced by genetic factors, which could be confounders if not taken into account in the assessment of the efficacy of interventions against malaria. This study aimed to assess the relationship between haemoglobin genotypes and malaria in children under five years in a site being characterized for future malaria vaccine trials. Methods The study population consisted of 452 children living in four rural villages. Hb genotype was determined at enrolment. Clinical malaria incidence was evaluated over a one-year period using combined active and passive surveillance. Prevalence of infection was evaluated via bi-annual cross-sectional surveys. At each follow-up visit, children received a brief clinical examination and thick and thin blood films were prepared for malaria diagnosis. A clinical malaria was defined as Plasmodium falciparum parasitaemia >2,500 parasites/μl and axillary temperature ≥37.5°C or reported fever over the previous 24 hours. Results Frequencies of Hb genotypes were 73.2% AA; 15.0% AC; 8.2% AS; 2.2% CC; 1.1% CS and 0.2% SS. Prevalence of infection at enrolment ranged from 61.9%-54.1% among AA, AC and AS children. After one year follow-up, clinical malaria incidence (95% CI) (episodes per person-year) was 1.9 (1.7-2.0) in AA, 1.6 (1.4-2.1) in AC, and 1.7 (1.4-2.0) in AS children. AC genotype was associated with lower incidence of clinical malaria relative to AA genotype among children aged 1–2 years [rate ratio (95% CI) 0.66 (0.42-1.05)] and 2–3 years [rate ratio (95% CI) 0.37 (0.18-0.75)]; an association of opposite direction was however apparent among children aged 3–4 years. AS genotype was associated with lower incidence of clinical malaria relative to AA genotype among children aged 2–3 years [rate ratio (95% CI) 0.63 (0.40-1.01)]. Conclusions In this cohort of children, AC or AS genotype was associated with lower risk of clinical malaria relative to AA genotype only among children aged one to three years. It would be advisable for clinical studies of malaria in endemic regions to consider haemoglobin gene differences as a potentially important confounder, particularly among younger children.
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- 2012
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6. Haematological parameters, natural regulatory CD4 + CD25 + FOXP3+ T cells and γδ T cells among two sympatric ethnic groups having different susceptibility to malaria in Burkina Faso
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Sanou Guillaume S, Tiendrebeogo Régis W, Ouédraogo André L, Diarra Amidou, Ouédraogo Alphonse, Yaro Jean-Baptiste, Ouédraogo Espérance, Verra Federica, Behr Charlotte, Troye-Blomberg Marita, Modiano David, Dolo Amagana, Torcia Maria G, Traoré Yves, Sirima Sodiomon B, and Nébié Issa
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Medicine ,Biology (General) ,QH301-705.5 ,Science (General) ,Q1-390 - Abstract
Abstract Background Fulani ethnic group individuals are less susceptible than sympatric Mossi ethnic group, in term of malaria infection severity, and differ in antibody production against malaria antigens. The differences in susceptibility to malaria between Fulani and Mossi ethnic groups are thought to be regulated by different genetic backgrounds and offer the opportunity to compare haematological parameters, Tregs and γδT cell profiles in seasonal and stable malaria transmission settings in Burkina Faso. The study was conducted at two different time points i.e. during the high and low malaria transmission period. Results Two cross-sectional surveys were undertaken in adults above 20 years belonging either to the Fulani or the Mossi ethnic groups 1) at the peak of the malaria transmission season and 2) during the middle of the low malaria transmission season. Full blood counts, proportions of Tregs and γδ T cells were measured at both time-points. As previously shown the Fulani and Mossi ethnic groups showed a consistent difference in P. falciparum infection rates and parasite load. Differential white blood cell counts showed that the absolute lymphocyte counts were higher in the Mossi than in the Fulani ethnic group at both time points. While the proportion of CD4+CD25high was higher in the Fulani ethnic group at the peak of malaria transmission season (p = 0.03), no clear pattern emerged for T regulatory cells expressing FoxP3+ and CD127low. However CD3+γδ+ subpopulations were found to be higher in the Fulani compared to the Mossi ethnic group, and this difference was statistically significant at both time-points (p = 0.004 at low transmission season and p = 0.04 at peak of transmission). Conclusion Our findings on regulatory T cell phenotypes suggest an interesting role for immune regulatory mechanisms in response to malaria. The study also suggests that TCRγδ + cells might contribute to the protection against malaria in the Fulani ethnic group involving their reported parasite inhibitory activities.
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- 2012
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7. Intermittent Preventive Treatment of Malaria Provides Substantial Protection against Malaria in Children Already Protected by an Insecticide-Treated Bednet in Burkina Faso: A Randomised, Double-Blind, Placebo-Controlled Trial
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Konaté, Amadou T., Yaro, Jean Baptiste, Ouédraogo, Amidou Z., Diarra, Amidou, Gansané, Adama, Soulama, Issiaka, Kangoyé, David T., Kaboré, Youssouf, Ouédraogo, Espérance, Ouédraogo, Alphonse, Tiono, Alfred B., Ouédraogo, Issa N., Chandramohan, Daniel, Cousens, Simon, Milligan, Paul J., Sirima, Sodiomon B., Greenwood, Brian, and Diallo, Diadier A.
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Public Health and Epidemiology/Infectious Diseases ,Amodiaquine ,Infant ,Malaria ,Antimalarials ,Drug Combinations ,Pyrimethamine ,Double-Blind Method ,Child, Preschool ,parasitic diseases ,Burkina Faso ,Sulfadoxine ,Humans ,Insecticide-Treated Bednets ,Research Article - Abstract
A randomized trial reported by Diadier Diallo and colleagues shows that intermittent preventive treatment for malaria in children who are protected from mosquitoes using insecticide-treated bednets provides substantial protection from malaria., Background Intermittent preventive treatment of malaria in children (IPTc) is a promising new approach to the control of malaria in areas of seasonal malaria transmission but it is not known if IPTc adds to the protection provided by an insecticide-treated net (ITN). Methods and Findings An individually randomised, double-blind, placebo-controlled trial of seasonal IPTc was conducted in Burkina Faso in children aged 3 to 59 months who were provided with a long-lasting insecticide-treated bednet (LLIN). Three rounds of treatment with sulphadoxine pyrimethamine plus amodiaquine or placebos were given at monthly intervals during the malaria transmission season. Passive surveillance for malaria episodes was established, a cross-sectional survey was conducted at the end of the malaria transmission season, and use of ITNs was monitored during the intervention period. Incidence rates of malaria were compared using a Cox regression model and generalized linear models were fitted to examine the effect of IPTc on the prevalence of malaria infection, anaemia, and on anthropometric indicators. 3,052 children were screened and 3,014 were enrolled in the trial; 1,505 in the control arm and 1,509 in the intervention arm. Similar proportions of children in the two treatment arms were reported to sleep under an LLIN during the intervention period (93%). The incidence of malaria, defined as fever or history of fever with parasitaemia ≥5,000/µl, was 2.88 (95% confidence interval [CI] 2.70–3.06) per child during the intervention period in the control arm versus 0.87 (95% CI 0.78–0.97) in the intervention arm, a protective efficacy (PE) of 70% (95% CI 66%–74%) (p, Editors' Summary Background Malaria accounts for one in five of all childhood deaths in Africa and of the one million annual malarial deaths world-wide, over 75% occur in African children under 5 years old. Malaria also causes severe morbidity in children, such as anemia, low birth weight, and neurological problems, which compromise the health and development of millions of children living in malaria endemic areas. As much of the impact of malaria on African children can be effectively prevented, significant efforts have been made in recent years to improve malaria control, such as the implementation of intermittent preventive treatment of malaria. Intermittent preventive treatment (IPT) involves administration of antimalarial drugs at defined time intervals to individuals, regardless of whether they are known to be infected with malaria, to prevent morbidity and mortality. IPT was initially recommended for pregnant women and recently this strategy was extended to include infants (IPTi). Now, there is also IPT of malaria in children (IPTc), which is designed to protect against malaria during the high malaria transmission season. Why Was This Study Done? Large clinical trials have shown that IPTc involving the administration of two to three doses of an antimalarial drug (sulphadoxine pyrimethamine [SP] and artesunate [AS] or amodiaquine [AQ]) during the high malaria transmission season effectively reduces the incidence of malaria. However, these studies were conducted in countries where the use of insecticide-treated bednets—an intervention that provides at least 50% protection against morbidity from malaria and is the main tool used for malaria control in most of sub-Saharan Africa—was relatively low. Therefore, it is unclear whether IPTc will be as effective in children who sleep under insecticide-treated bednets as has been previously shown in communities where insecticide-treated bednet usage is low. So to determine the answer to this important question, the researchers conducted a randomized, placebo-controlled trial of IPTc with SP + AQ (chosen because of the effectiveness of this combination in a pilot study) in children who slept under an insecticide-treated bednet in an area of seasonal malaria transmission in Burkina Faso. What Did the Researchers Do and Find? The researchers enrolled 3,014 eligible children aged 3–59 months into a randomized double-blind, placebo-controlled trial during the 2008 malaria transmission season in Burkina Faso. All children were given a long-lasting insecticide-treated bednet at the start of the study with instructions to their family on the correct use of the net. Children were then randomized into two arms—1,509 were allocated to the intervention group and 1,505 to the control group—to receive three courses of IPTc with SP plus AQ or placebos given at monthly intervals during the peak malaria transmission season. The researchers monitored the incidence of malaria throughout the malaria season and also monitored the use of long-lasting insecticide-treated bednets throughout the study period. In addition, researchers conducted a cross-sectional survey in 150 randomly selected children every week and in every child enrolled in the trial 6 weeks after the last course of IPTc, to measure their temperature, height and weight, and blood hemoglobin and parasite count levels. The number of children who slept under their long-lasting insecticide-treated bednet was similar in both arms. During the intervention period, the researchers found that the incidence of clinical malaria (defined as fever or a history of fever and the presence of at least 5,000 asexual forms of P. falciparum per microliter) was 2.88 in the control arm versus 0.87 in the intervention arm—giving a protective efficacy of 70%. There were 13 cases of severe malaria in the control arm and four in the IPTc arm—a 69% reduction in incidence. Additionally, all-cause hospital admission rate was reduced by 46%. At the end of the malaria transmission period, IPTc reduced the proportion of children infected with malaria parasites by 73% and reduced anemia by 33%. In addition, IPTc appeared to reduce the risk of wasting (risk ratio = 0.79) and of being underweight (risk ratio = 0.84). However, children who received IPTc were almost three times more likely to vomit than children who received placebo but there were no drug-related serious adverse events. What Do These Findings Mean? The results of this study show that in peak malarial transmission season in Burkina Faso, IPTc provides substantial additional protection against episodes of clinical malaria, severe malaria, and all-cause hospital admissions in children sleeping under long-lasting insecticide-treated bednets. In addition, intermittent preventive treatment of malaria with SP plus AQ appears to be safe for use in children. Additional Information Please access these websites via the online version of this summary at http://dx.doi.org/10.1371/journal.pmed.1000408. This topic is further discussed in two PLoS Medicine research articles: Dicko et al. and Bojang et al., and in a PLoS Medicine Perspective by Beeson Roll Back Malaria has information about malaria in children, including intervention strategies UNICEF also provides comprehensive information about malaria in children The Intermittent Preventive Treatment in Infants Consortium (ipti) provides information on intermittent preventive treatment in infants Roll Back Malaria has an information sheet on insecticide-treated bednets
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- 2011
8. Morbidity from Malaria in Children in the Year after They Had Received Intermittent Preventive Treatment of Malaria: A Randomised Trial
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Konaté, Amadou T., primary, Yaro, Jean Baptiste, additional, Ouédraogo, Amidou Z., additional, Diarra, Amidou, additional, Gansané, Adama, additional, Soulama, Issiaka, additional, Kangoyé, David T., additional, Kaboré, Youssouf, additional, Ouédraogo, Espérance, additional, Ouédraogo, Alphonse, additional, Tiono, Alfred B., additional, Ouédraogo, Issa N., additional, Chandramohan, Daniel, additional, Cousens, Simon, additional, Milligan, Paul J., additional, Sirima, Sodiomon B., additional, Greenwood, Brian M., additional, and Diallo, Diadier A., additional
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- 2011
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9. Correction: Safety and Immunogenicity of the Malaria Vaccine Candidate MSP3 Long Synthetic Peptide in 12–24 Months-Old Burkinabe Children
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Sirima, Sodiomon B., primary, Tiono, Alfred B., additional, Ouédraogo, Alphonse, additional, Diarra, Amidou, additional, Ouédraogo, André Lin, additional, Yaro, Jean Baptiste, additional, Ouédraogo, Espérance, additional, Gansané, Adama, additional, Bougouma, Edith C., additional, Konaté, Amadou T., additional, Kaboré, Youssouf, additional, Traoré, Abdoulaye, additional, Roma, Chilengi, additional, Soulama, Issiaka, additional, Luty, Adrian J. F., additional, Druilhe, Pierre, additional, Cousens, Simon, additional, and Nébié, Issa, additional
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- 2010
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10. Safety and Immunogenicity of the Malaria Vaccine Candidate MSP3 Long Synthetic Peptide in 12–24 Months-Old Burkinabe Children
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Sirima, Sodiomon B., primary, Tiono, Alfred B., additional, Ouédraogo, Alphonse, additional, Diarra, Amidou, additional, Ouédraogo, André Lin, additional, Yaro, Jean Baptiste, additional, Ouédraogo, Espérance, additional, Gansané, Adama, additional, Bougouma, Edith C., additional, Konaté, Amadou T., additional, Kaboré, Youssouf, additional, Traoré, Abdoulaye, additional, Roma, Chilengi, additional, Soulama, Issiaka, additional, Luty, Adrian J. F., additional, Cousens, Simon, additional, and Nébié, Issa, additional
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- 2009
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