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Compute eXpress Link (CXL) is a pivotal technology for memory disaggregation in future heterogeneous computing systems, enabling on-demand memory expansion and improved resource utilization. Despite its potential, CXL is in its early stages with limited market products, highlighting the need for a reliable system-level simulation tool. This paper introduces CXL-DMSim, an open-source, high-fidelity full-system simulator for CXL disaggregated memory systems, comparable in speed to gem5. CXL-DMSim includes a flexible CXL memory expander model, device driver, and support for CXL\.io and CXL\.mem protocols. It supports both app-managed and kernel-managed modes, with the latter featuring a NUMA-compatible mechanism. Rigorous verification against real hardware testbeds with FPGA-based and ASIC-based CXL memory prototypes confirms CXL-DMSim's accuracy, with an average simulation error of 4.1%. Benchmark results using LMbench and STREAM indicate that CXL-FPGA memory has approximately ~2.88x higher latency than local DDR, while CXL-ASIC latency is about ~2.18x. CXL-FPGA achieves 45-69% of local DDR's memory bandwidth, and CXL-ASIC reaches 82-83%. The performance of CXL memory is significantly more sensitive to Rd/Wr patterns than local DDR, with optimal bandwidth at a 74%:26% ratio rather than 50%:50% due to the current CXL+DDR controller design. The study also shows that CXL memory can markedly enhance the performance of memory-intensive applications, with the most improvement seen in Viper (~23x) and in bandwidth-sensitive scenarios like MERCI (16%). CXL-DMSim's observability and expandability are demonstrated through detailed case studies, showcasing its potential for research on future CXL-interconnected hybrid memory pools., Comment: 15 pages, 19 figures

In recent years, the rapid aging of the global population has led to an increase in cognitive disorders, such as Alzheimer's disease, presenting significant public health challenges. Although no effective treatments currently exist to reverse Alzheimer's, prevention and early intervention, including cognitive training, are critical. This report explores the potential of AI chatbots in enhancing personalized cognitive training. We introduce ReMe, a web-based framework designed to create AI chatbots that facilitate cognitive training research, specifically targeting episodic memory tasks derived from personal life logs. By leveraging large language models, ReMe provides enhanced user-friendly, interactive, and personalized training experiences. Case studies demonstrate ReMe's effectiveness in engaging users through life recall and open-ended language puzzles, highlighting its potential to improve cognitive training design. Despite promising results, further research is needed to validate training effectiveness through large-scale studies that include cognitive ability evaluations. Overall, ReMe offers a promising approach to personalized cognitive training, utilizing AI capabilities to meet the growing demand for non-pharmacological interventions in cognitive health, with future research aiming to expand its applications and efficacy.

The prompt emission mechanism of gamma-ray bursts (GRBs) is a long-standing open question, and GRBs have been considered as potential sources of high-energy neutrinos. Despite many years of search for the neutrino events associated with GRBs from IceCube, there were no results. However, the absence of search results for neutrinos provides a unique opportunity to constrain the parameter space of GRB jet models. In this paper, we chose four peculiar GRBs with two different types of jet composition to investigate neutrino emission. It is found that only GRB 211211A could be well constrained within the dissipative photosphere model. By adopting the specific parameters of the photosphere, one can obtain $\varepsilon _{\rm p}/\varepsilon_{\rm e}<8$ for $f_{\rm p}>0.2$ from GRB 211211A. For the Internal-collision-induced Magnetic Reconnection and Turbulence (ICMART) model, we can effectively constrain neither GRB 230307A nor GRB 080916C. Moreover, we also investigate the detection prospects of high-energy neutrinos from GRBs and find that it is difficult to detect at least one high-energy neutrino associated with GRBs from the ICMART model even during the IceCube-Gen2 operation. For the GRB 211211A-like events, it is possible to detect at least one neutrino coincident with the gravitational wave during the IceCube-Gen2 operation, if such an event originated from mergers of compact stars within the photosphere dissipation., Comment: 15 pages, 10 figures, matched with the published verison

We calculate the complete $T$ matrices with decuplet contributions for pion-nucleon scattering to order $\mathcal{O}(\epsilon^3)$ in heavy baryon SU(3) chiral perturbation theory. The baryon mass in the chiral limit $M_0$ and the low-energy constants are determined by fitting to phase shifts of $\pi N$, the experimental octet-baryon masses, and the value of $\sigma_{\pi N}$ simultaneously. By using these constants, we obtain the $KN$ $\sigma$ terms, $\sigma_{KN}^{(1)}=(375.07\pm33.02)$ MeV and $\sigma_{KN}^{(2)}=(275.32\pm32.24)$ MeV, with the errors being only statistical. An excellent description of the phase shifts is obtained for all partial waves. We also present results for scattering lengths and scattering volumes. In addition, the convergence of the approach is also discussed., Comment: 29 pages, 6 figures, 5 tables

The crystal structure can be simplified as a periodic point set repeating across the entire three-dimensional space along an underlying lattice. Traditionally, methods for representing crystals rely on descriptors like lattice parameters, symmetry, and space groups to characterize the structure. However, in reality, atoms in material always vibrate above absolute zero, causing continuous fluctuations in their positions. This dynamic behavior disrupts the underlying periodicity of the lattice, making crystal graphs based on static lattice parameters and conventional descriptors discontinuous under even slight perturbations. To this end, chemists proposed the Pairwise Distance Distribution (PDD) method, which has been used to distinguish all periodic structures in the world's largest real materials collection, the Cambridge Structural Database. However, achieving the completeness of PDD requires defining a large number of neighboring atoms, resulting in high computational costs. Moreover, it does not account for atomic information, making it challenging to directly apply PDD to crystal material property prediction tasks. To address these challenges, we propose the atom-Weighted Pairwise Distance Distribution (WPDD) and Unit cell Pairwise Distance Distribution (UPDD) for the first time, incorporating them into the construction of multi-edge crystal graphs. Based on this, we further developed WPDDFormer and UPDDFormer, graph transformer architecture constructed using WPDD and UPDD crystal graphs. We demonstrate that this method maintains the continuity and completeness of crystal graphs even under slight perturbations in atomic positions., Comment: 8 pages, 3 figures

Using Multi-Layer Perceptrons (MLP) and Kolmogorov-Arnold Networks (KAN), we construct a holographic model based on lattice QCD data for the heavy-quark potential in the 2+1 system. The deformation factor $w(r)$ in the metric is obtained using the two types of neural network. First, we numerically obtain $w(r)$ using MLP, accurately reproducing the QCD results of the lattice, and calculate the heavy quark potential at finite temperature and the chemical potential. Subsequently, we employ KAN within the Andreev-Zakharov model for validation purpose, which can analytically reconstruct $w(r)$, matching the Andreev-Zakharov model exactly and confirming the validity of MLP. Finally, we construct an analytical holographic model using KAN and study the heavy-quark potential at finite temperature and chemical potential using the KAN-based holographic model. This work demonstrates the potential of KAN to derive analytical expressions for high-energy physics applications.

Predicting the docking between proteins and ligands is a crucial and challenging task for drug discovery. However, traditional docking methods mainly rely on scoring functions, and deep learning-based docking approaches usually neglect the 3D spatial information of proteins and ligands, as well as the graph-level features of ligands, which limits their performance. To address these limitations, we propose an equivariant transformer neural network for protein-ligand docking pose prediction. Our approach involves the fusion of ligand graph-level features by feature processing, followed by the learning of ligand and protein representations using our proposed TAMformer module. Additionally, we employ an iterative optimization approach based on the predicted distance matrix to generate refined ligand poses. The experimental results on real datasets show that our model can achieve state-of-the-art performance.

Electrification of transport compounded with climate change will transform hourly load profiles and their response to weather. Power system operators and EV charging stakeholders require such high-resolution load profiles for their planning studies. However, such profiles accounting whole transportation sector is lacking. Thus, we present a novel approach to generating hourly electric load profiles that considers charging strategies and evolving sensitivity to temperature. The approach consists of downscaling annual state-scale sectoral load projections from the multi-sectoral Global Change Analysis Model (GCAM) into hourly electric load profiles leveraging high resolution climate and population datasets. Profiles are developed and evaluated at the Balancing Authority scale, with a 5-year increment until 2050 over the Western U.S. Interconnect for multiple decarbonization pathways and climate scenarios. The datasets are readily available for production cost model analysis. Our open source approach is transferable to other regions.

Magnetic resonance spectroscopy (MRS) is an important clinical imaging method for diagnosis of diseases. MRS spectrum is used to observe the signal intensity of metabolites or further infer their concentrations. Although the magnetic resonance vendors commonly provide basic functions of spectra plots and metabolite quantification, the widespread clinical research of MRS is still limited due to the lack of easy-to-use processing software or platform. To address this issue, we have developed CloudBrain-MRS, a cloud-based online platform that provides powerful hardware and advanced algorithms. The platform can be accessed simply through a web browser, without the need of any program installation on the user side. CloudBrain-MRS also integrates the classic LCModel and advanced artificial intelligence algorithms and supports batch preprocessing, quantification, and analysis of MRS data from different vendors. Additionally, the platform offers useful functions: 1) Automatically statistical analysis to find biomarkers for diseases; 2) Consistency verification between the classic and artificial intelligence quantification algorithms; 3) Colorful three-dimensional visualization for easy observation of individual metabolite spectrum. Last, both healthy and mild cognitive impairment patient data are used to demonstrate the functions of the platform. To the best of our knowledge, this is the first cloud computing platform for in vivo MRS with artificial intelligence processing. We have shared our cloud platform at MRSHub, providing free access and service for two years. Please visit https://mrshub.org/software_all/#CloudBrain-MRS or https://csrc.xmu.edu.cn/CloudBrain.html., Comment: 11 pages, 12 figures

Artificial Intelligence (AI) has made incredible progress recently. On the one hand, advanced foundation models like ChatGPT can offer powerful conversation, in-context learning and code generation abilities on a broad range of open-domain tasks. They can also generate high-level solution outlines for domain-specific tasks based on the common sense knowledge they have acquired. However, they still face difficulties with some specialized tasks because they lack enough domain-specific data during pre-training or they often have errors in their neural network computations on those tasks that need accurate executions. On the other hand, there are also many existing models and systems (symbolic-based or neural-based) that can do some domain-specific tasks very well. However, due to the different implementation or working mechanisms, they are not easily accessible or compatible with foundation models. Therefore, there is a clear and pressing need for a mechanism that can leverage foundation models to propose task solution outlines and then automatically match some of the sub-tasks in the outlines to the off-the-shelf models and systems with special functionalities to complete them. Inspired by this, we introduce TaskMatrix.AI as a new AI ecosystem that connects foundation models with millions of APIs for task completion. Unlike most previous work that aimed to improve a single AI model, TaskMatrix.AI focuses more on using existing foundation models (as a brain-like central system) and APIs of other AI models and systems (as sub-task solvers) to achieve diversified tasks in both digital and physical domains. As a position paper, we will present our vision of how to build such an ecosystem, explain each key component, and use study cases to illustrate both the feasibility of this vision and the main challenges we need to address next.

Identifying causal treatment (or exposure) effects in observational studies requires the data to satisfy the unconfoundedness assumption which is not testable using the observed data. With sensitivity analysis, one can determine how the conclusions might change if assumptions are violated to a certain degree. In this paper, we propose a new technique for sensitivity analysis applicable to clusters observational data with a normally distributed or binary outcome. The proposed methods aim to assess the robustness of estimated treatment effects in a single study as well as in multiple studies, i.e., meta-analysis, against unmeasured confounders. Simulations with various underlying scenarios were conducted to assess the performance of our methods. Unlike other existing sensitivity analysis methods, our methods have no restrictive assumptions on the number of unmeasured confounders or on the relationship between measured and unmeasured confounders, and do not exclude possible interactions between measured confounders and the treatment. Our methods are easy to implement using standard statistical software packages.