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12. Comparing the Associations of Dietary Patterns Identified through Principal Component Analysis and Cluster Analysis with Colorectal Cancer Risk: A Large Case–Control Study in China.

Author

Ma, Ting, Tu, Kexin, Ou, Qingjian, Fang, Yujing, and Zhang, Caixia

Abstract

Examining the association between dietary patterns and colorectal cancer (CRC) risk can provide valuable insights beyond the assessment of individual foods or nutrients. However, there is a lack of in-depth analysis of dietary patterns and CRC risk in Chinese populations, and few studies have compared dietary patterns derived from different posteriori methods with the aim of predicting disease risk. The aim of this study was to derive dietary patterns using both principal component analysis (PCA) and cluster analysis (CA) and to assess their respective associations with CRC risk. A large-scale case-control study was conducted in Guangdong Province, China, including 2799 incident colorectal cancer cases and an equal number of frequency-matched controls. Dietary intake information was gathered through the use of a validated food frequency questionnaire. PCA and CA were used to derive dietary patterns. A multivariable logistic regression model was used to calculate the adjusted odds ratio (aOR) and 95% confidence interval (CI). Four major dietary patterns were identified by PCA. CA identified two dietary patterns, referred to as the "Balanced dietary pattern" and the "Refined grain dietary pattern". Notably, there were significant inverse associations between the milk-egg-nut-soy dietary pattern (aOR, 0.51; 95% CI, 0.42, 0.62), the vegetable-fruit dietary pattern (aOR, 0.61; 95%CI, 0.51, 0.74), and the poultry-fish dietary pattern (aOR, 0.81; 95%CI, 0.68, 0.97) and CRC risk. However, the red meat-preserved food dietary pattern was associated with an increased risk of CRC (aOR, 2.99; 95%CI, 2.43, 3.67). When compared with the Refined grain dietary pattern, the Balanced dietary pattern showed a decreased risk of CRC (aOR, 0.59; 95%CI, 0.52, 0.66). The results from the comparison of the two methods indicate that both CA and PCA derived remarkably similar patterns. The combined use of PCA and CA identified consistent underlying patterns, showing comparable associations with CRC risk. These findings suggest that individuals who prefer dietary patterns characterized by a high intake of red meat, preserved food, and refined grains should be cautious about their increased CRC risk. Conversely, dietary patterns rich in fruits, vegetables, and high-quality protein sources are advisable for the prevention of CRC in the Chinese population. [ABSTRACT FROM AUTHOR]

Published
2024
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13. Tumor-derived lactate promotes resistance to bevacizumab treatment by facilitating autophagy enhancer protein RUBCNL expression through histone H3 lysine 18 lactylation (H3K18la) in colorectal cancer.

Author

Li, Weihao, Zhou, Chi, Yu, Long, Hou, Zhenlin, Liu, Huashan, Kong, Lingheng, Xu, Yanbo, He, Jiahua, Lan, Jin, Ou, Qingjian, Fang, Yujing, Lu, Zhenhai, Wu, Xiaojun, Pan, Zhizhong, Peng, Jianhong, and Lin, Junzhong

Subjects
BEVACIZUMAB, COLORECTAL cancer, TUBULINS, PROTEIN expression, AUTOPHAGY, CANCER cell proliferation
Abstract

Bevacizumab plays an important role in the first and second line treatment for metastatic colorectal cancer (CRC). And induction of hypoxia and the tumors response to it plays an important role in determining the efficacy of antiangiogenic therapy while the connection between them remains unclear. Here, we found that lactate accumulated in the tumor environment of CRC and acted as substrates for histone lactylation, and this process was further induced by cellular enhanced glycolysis in hypoxia. We determined that CRC patients resistant to bevacizumab treatment presented with elevated levels of histone lactylation and inhibition of histone lactylation efficiently suppressed CRC tumorigenesis, progression and survival in hypoxia. Histone lactylation promoted the transcription of RUBCNL/Pacer, facilitating autophagosome maturation through interacting with BECN1 (beclin 1) and mediating the recruitment and function of the class III phosphatidylinositol 3-kinase complex, which had a crucial role in hypoxic cancer cells proliferation and survival. Moreover, combining inhibition of histone lactylation and macroautophagy/autophagy with bevacizumab treatment demonstrated remarkable treatment efficacy in bevacizumab-resistance patients-derived pre-clinical models. These findings delivered a new exploration and important supplement of metabolic reprogramming-epigenetic regulation, and provided a new strategy for improving clinical efficacy of bevacizumab in CRC by inhibition of histone lactylation. Abbreviations: 2-DG: 2-deoxy-D-glucose; BECN1: beclin 1; CQ: chloroquine; CRC: colorectal cancer; DMOG: dimethyloxalylglycine; H3K18la: histone H3 lysine 18 lactylation; MAP1LC3B/LC3B: microtubule associated protein 1 light chain 3 beta; Nala: sodium lactate; PDO: patient-derived orgnoid; PDX: patient-derived xenograft; RUBCNL/Pacer: rubicon like autophagy enhancer; SQSTM1/p62: sequestosome 1. [ABSTRACT FROM AUTHOR]

Published
2024
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14. Tumor-derived lactate promotes resistance to bevacizumab treatment by facilitating autophagy enhancer protein RUBCNL expression through histone H3 lysine 18 lactylation (H3K18la) in colorectal cancer

Author

Li, Weihao, primary, Zhou, Chi, additional, Yu, Long, additional, Hou, Zhenlin, additional, Liu, Huashan, additional, Kong, Lingheng, additional, Xu, Yanbo, additional, He, Jiahua, additional, Lan, Jin, additional, Ou, Qingjian, additional, Fang, Yujing, additional, Lu, Zhenhai, additional, Wu, Xiaojun, additional, Pan, Zhizhong, additional, Peng, Jianhong, additional, and Lin, Junzhong, additional

Published
2023
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15. Subconjunctival injection of human umbilical cord mesenchymal stem cells alleviates experimental allergic conjunctivitis via regulating T cell response

Author

Li, Dongli, primary, Ou, Qingjian, additional, Shen, Qi, additional, Lu, Michael Mingze, additional, Xu, Jing-Ying, additional, Jin, Caixia, additional, Gao, Furong, additional, Wang, Juan, additional, Zhang, Jingfa, additional, Zhang, Jieping, additional, Li, Jiao, additional, Lu, Lixia, additional, Xu, Guo-Tong, additional, and Tian, Haibin, additional

Published
2023
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17. Glia maturation factor beta deficiency protects against diabetic osteoporosis by suppressing osteoclast hyperactivity

Author

Shi, Si, primary, Gu, Huijie, additional, Xu, Jinyuan, additional, Sun, Wan, additional, Liu, Caiyin, additional, Zhu, Tong, additional, Wang, Juan, additional, Gao, Furong, additional, Zhang, Jieping, additional, Ou, Qingjian, additional, Jin, Caixia, additional, Xu, Jingying, additional, Chen, Hao, additional, Li, Jiao, additional, Xu, Guotong, additional, Tian, Haibin, additional, and Lu, Lixia, additional

Published
2023
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21. Development and Validation of Serum Nomogram for Colorectal Cancer Screening

Author

Yu, Long, primary, Wang, Hao, additional, Wang, Fu-long, additional, Guo, Jian, additional, Xiao, Binyi, additional, Hou, Zhenlin, additional, Lu, Zhenhai, additional, Pan, Zhizhong, additional, Zhou, Yaxian, additional, Ye, Sibin, additional, Wan, Desen, additional, Lin, Bo, additional, Ou, Qingjian, additional, and Fang, Yujing, additional

Published
2023
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23. Identification of multi-omic biomarkers from Fecal DNA for improved Detection of Colorectal Cancer and precancerous lesions

Author

Fang, Yujing, primary, Peng, Jiaxi, additional, Li, Zhilong, additional, Jiang, Ruijingfang, additional, Lin, Yuxiang, additional, Shi, Ying, additional, Sun, Jianlong, additional, Zhuo, Duan, additional, Ou, Qingjian, additional, Chen, Jiali, additional, Wang, Xiaohan, additional, Cai, Jielun, additional, Zhu, Shida, additional, Wan, Desen, additional, Wang, Yuying, additional, and Lu, Zhenhai, additional

Published
2022
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25. Glia Maturation Factor β as a Novel Independent Prognostic Biomarker and Potential Therapeutic Target of Kidney Renal Clear Cell Carcinoma

Author

Zhu, Tong, primary, Wang, Tianyu, additional, Feng, Zijun, additional, Gao, Furong, additional, Zhang, Jieping, additional, Jin, Caixia, additional, Tian, Haibin, additional, Xu, Jingying, additional, Chen, Hao, additional, Ou, Qingjian, additional, Wang, Juan, additional, Xu, Guotong, additional, and Lu, Lixia, additional

Published
2022
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26. Glia maturation factor-β induces ferroptosis by impairing chaperone-mediated autophagic degradation of ACSL4 in early diabetic retinopathy

Author

Liu, Caiying, primary, Sun, Wan, additional, Zhu, Tong, additional, Shi, Si, additional, Zhang, Jieping, additional, Wang, Juan, additional, Gao, Furong, additional, Ou, Qingjian, additional, Jin, Caixia, additional, Li, Jiao, additional, Xu, Jing-Ying, additional, Zhang, Jingfa, additional, Tian, Haibin, additional, Xu, Guo-Tong, additional, and Lu, Lixia, additional

Published
2022
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28. sj-docx-1-tej-10.1177_20417314221122123 – Supplemental material for Human amniotic epithelial cell-derived extracellular vesicles provide an extracellular matrix-based microenvironment for corneal injury repair

Author

Hu, Shuqin, Wang, Zhe, Jin, Caixia, Chen, Qizhen, Fang, Yuchen, Jin, Jiahui, Chen, Jie, Lu, Lixia, Tian, Haibin, Xu, Jingying, Gao, Furong, Wang, Juan, Zhang, Jieping, Cui, Hong-Ping, Xu, Guo-Tong, and Ou, Qingjian

Subjects
110599 Dentistry not elsewhere classified, FOS: Clinical medicine, FOS: Biological sciences, 69999 Biological Sciences not elsewhere classified
Abstract

Supplemental material, sj-docx-1-tej-10.1177_20417314221122123 for Human amniotic epithelial cell-derived extracellular vesicles provide an extracellular matrix-based microenvironment for corneal injury repair by Shuqin Hu, Zhe Wang, Caixia Jin, Qizhen Chen, Yuchen Fang, Jiahui Jin, Jie Chen, Lixia Lu, Haibin Tian, Jingying Xu, Furong Gao, Juan Wang, Jieping Zhang, Hong-Ping Cui, Guo-Tong Xu and Qingjian Ou in Journal of Tissue Engineering

Published
2022
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29. sj-docx-2-tej-10.1177_20417314221122123 – Supplemental material for Human amniotic epithelial cell-derived extracellular vesicles provide an extracellular matrix-based microenvironment for corneal injury repair

Author

Hu, Shuqin, Wang, Zhe, Jin, Caixia, Chen, Qizhen, Fang, Yuchen, Jin, Jiahui, Chen, Jie, Lu, Lixia, Tian, Haibin, Xu, Jingying, Gao, Furong, Wang, Juan, Zhang, Jieping, Cui, Hong-Ping, Xu, Guo-Tong, and Ou, Qingjian

Subjects
110599 Dentistry not elsewhere classified, FOS: Clinical medicine, FOS: Biological sciences, 69999 Biological Sciences not elsewhere classified
Abstract

Supplemental material, sj-docx-2-tej-10.1177_20417314221122123 for Human amniotic epithelial cell-derived extracellular vesicles provide an extracellular matrix-based microenvironment for corneal injury repair by Shuqin Hu, Zhe Wang, Caixia Jin, Qizhen Chen, Yuchen Fang, Jiahui Jin, Jie Chen, Lixia Lu, Haibin Tian, Jingying Xu, Furong Gao, Juan Wang, Jieping Zhang, Hong-Ping Cui, Guo-Tong Xu and Qingjian Ou in Journal of Tissue Engineering

Published
2022
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30. sj-docx-4-tej-10.1177_20417314221122123 – Supplemental material for Human amniotic epithelial cell-derived extracellular vesicles provide an extracellular matrix-based microenvironment for corneal injury repair

Author

Hu, Shuqin, Wang, Zhe, Jin, Caixia, Chen, Qizhen, Fang, Yuchen, Jin, Jiahui, Chen, Jie, Lu, Lixia, Tian, Haibin, Xu, Jingying, Gao, Furong, Wang, Juan, Zhang, Jieping, Cui, Hong-Ping, Xu, Guo-Tong, and Ou, Qingjian

Subjects
110599 Dentistry not elsewhere classified, FOS: Clinical medicine, FOS: Biological sciences, 69999 Biological Sciences not elsewhere classified
Abstract

Supplemental material, sj-docx-4-tej-10.1177_20417314221122123 for Human amniotic epithelial cell-derived extracellular vesicles provide an extracellular matrix-based microenvironment for corneal injury repair by Shuqin Hu, Zhe Wang, Caixia Jin, Qizhen Chen, Yuchen Fang, Jiahui Jin, Jie Chen, Lixia Lu, Haibin Tian, Jingying Xu, Furong Gao, Juan Wang, Jieping Zhang, Hong-Ping Cui, Guo-Tong Xu and Qingjian Ou in Journal of Tissue Engineering

Published
2022
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32. sj-docx-3-tej-10.1177_20417314221122123 – Supplemental material for Human amniotic epithelial cell-derived extracellular vesicles provide an extracellular matrix-based microenvironment for corneal injury repair

Author

Hu, Shuqin, Wang, Zhe, Jin, Caixia, Chen, Qizhen, Fang, Yuchen, Jin, Jiahui, Chen, Jie, Lu, Lixia, Tian, Haibin, Xu, Jingying, Gao, Furong, Wang, Juan, Zhang, Jieping, Cui, Hong-Ping, Xu, Guo-Tong, and Ou, Qingjian

Subjects
110599 Dentistry not elsewhere classified, FOS: Clinical medicine, FOS: Biological sciences, 69999 Biological Sciences not elsewhere classified
Abstract

Supplemental material, sj-docx-3-tej-10.1177_20417314221122123 for Human amniotic epithelial cell-derived extracellular vesicles provide an extracellular matrix-based microenvironment for corneal injury repair by Shuqin Hu, Zhe Wang, Caixia Jin, Qizhen Chen, Yuchen Fang, Jiahui Jin, Jie Chen, Lixia Lu, Haibin Tian, Jingying Xu, Furong Gao, Juan Wang, Jieping Zhang, Hong-Ping Cui, Guo-Tong Xu and Qingjian Ou in Journal of Tissue Engineering

Published
2022
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33. Identification of Novel Key Molecular Signatures in the Pathogenesis of Experimental Diabetic Kidney Disease

Author

Diao, Meng, primary, Wu, Yimu, additional, Yang, Jialu, additional, Liu, Caiying, additional, Xu, Jinyuan, additional, Jin, Hongchao, additional, Wang, Juan, additional, Zhang, Jieping, additional, Gao, Furong, additional, Jin, Caixia, additional, Tian, Haibin, additional, Xu, Jingying, additional, Ou, Qingjian, additional, Li, Ying, additional, Xu, Guotong, additional, and Lu, Lixia, additional

Published
2022
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34. Human amniotic epithelial cell-derived extracellular vesicles provide an extracellular matrix-based microenvironment for corneal injury repair

Author

Hu, Shuqin, primary, Wang, Zhe, additional, Jin, Caixia, additional, Chen, Qizhen, additional, Fang, Yuchen, additional, Jin, Jiahui, additional, Chen, Jie, additional, Lu, Lixia, additional, Tian, Haibin, additional, Xu, Jingying, additional, Gao, Furong, additional, Wang, Juan, additional, Zhang, Jieping, additional, Cui, Hong-Ping, additional, Xu, Guo-Tong, additional, and Ou, Qingjian, additional

Published
2022
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36. Chaperone-Mediated Autophagy Plays an Important Role in Regulating Retinal Progenitor Cell Homeostasis

Author

Jin, Caixia, primary, Ou, Qingjian, additional, Chen, Jie, additional, Wang, Tao, additional, Zhang, Jieping, additional, Wang, Zhe, additional, Wang, Yuanyuan, additional, Tian, Haibin, additional, Xu, Jing-Ying, additional, Gao, Furong, additional, Wang, Juan, additional, Li, Jiao, additional, Lu, Lixia, additional, and Xu, Guo-Tong, additional

Published
2021
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39. Corrigendum to “Voltage-gated sodium channel Nav1.5 promotes tumor progression and enhances chemosensitivity to 5-fluorouracil in colorectal cancer” [Canc. Lett. 500 (2021) 119-131]

Author

Sui, Qiaoqi, primary, Peng, Jianhong, additional, Han, Kai, additional, Lin, Junzhong, additional, Zhang, Rongxin, additional, Ou, Qingjian, additional, Qin, Jiayi, additional, Deng, Yuxiang, additional, Zhou, Wenhao, additional, Kong, Lingheng, additional, Tang, Jinghua, additional, Xiao, Binyi, additional, Li, Yuan, additional, Yu, Long, additional, Fang, Yujing, additional, Ding, Pei-Rong, additional, and Pan, Zhizhong, additional

Published
2021
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40. Additional file 2 of BMSC-derived extracellular vesicles intervened the pathogenic changes of scleroderma in mice through miRNAs

Author

Jin, Jiahui, Ou, Qingjian, Wang, Zhe, Tian, Haibin, Xu, Jing-Ying, Gao, Furong, Hu, Shuqin, Chen, Jie, Wang, Juan, Zhang, Jieping, Lu, Lixia, Jin, Caixia, Xu, Guo-Tong, and Zhao, Jingjun

Abstract

Additional file 2: Supplemental Fig. 2. BMSC-derived EVs suppress the TGF-β1-induced myofibroblast differentiation of mouse fibroblasts. (a) Protein expression profiles of SSc-related ECM and inflammatory factors in vitro. (b) Proteins related to WNT signaling pathway and TGFβ signaling pathway activation.

Published
2021
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41. Additional file 1 of BMSC-derived extracellular vesicles intervened the pathogenic changes of scleroderma in mice through miRNAs

Author

Jin, Jiahui, Ou, Qingjian, Wang, Zhe, Tian, Haibin, Xu, Jing-Ying, Gao, Furong, Hu, Shuqin, Chen, Jie, Wang, Juan, Zhang, Jieping, Lu, Lixia, Jin, Caixia, Xu, Guo-Tong, and Zhao, Jingjun

Subjects
integumentary system
Abstract

Additional file 1: Supplemental Fig. 1. GO analysis of the DEGs between BLM-induced SSc and control skin and between EV-treated and control skin. (a-b) GO Chord analysis results showing the Gene Ontology functions of differentially expressed genes between BLM-induced SSc skin and normal skin (a) and between BMSC-EV-treated skin and normal skin (b).

Published
2021
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43. Effectively Intervening Epithelial-Mesenchymal Transition of Retinal Pigment Epithelial Cells With a Combination of ROCK and TGF-β Signaling Inhibitors

Author

Chen, Yi, primary, Wu, Binxin, additional, He, Jian Feng, additional, Chen, Jingyao, additional, Kang, Zi Wei, additional, Liu, Dandan, additional, Luo, Junjie, additional, Fang, Kexin, additional, Leng, Xiaoxu, additional, Tian, Haibin, additional, Xu, Jingying, additional, Jin, Caixia, additional, Zhang, Jieping, additional, Wang, Juan, additional, Zhang, Jingfa, additional, Ou, Qingjian, additional, Lu, Lixia, additional, Gao, Furong, additional, and Xu, Guo-Tong, additional

Published
2021
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45. Voltage-gated sodium channel Nav1.5 promotes tumor progression and enhances chemosensitivity to 5-fluorouracil in colorectal cancer

Author

Sui, Qiaoqi, primary, Peng, Jianhong, additional, Han, Kai, additional, Lin, Junzhong, additional, Zhang, Rongxin, additional, Ou, Qingjian, additional, Qin, Jiayi, additional, Deng, Yuxiang, additional, Zhou, Wenhao, additional, Kong, Lingheng, additional, Tang, Jinghua, additional, Xiao, Binyi, additional, Li, Yuan, additional, Yu, Long, additional, Fang, Yujing, additional, Ding, Pei-Rong, additional, and Pan, Zhizhong, additional

Published
2021
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46. Dickkopf 1 impairs the tumor response to PD-1 blockade by inactivating CD8+ T cells in deficient mismatch repair colorectal cancer

Author

Sui, Qiaoqi, primary, Liu, Dingxin, additional, Jiang, Wu, additional, Tang, Jinghua, additional, Kong, Lingheng, additional, Han, Kai, additional, Liao, Leen, additional, Li, Yuan, additional, Ou, Qingjian, additional, Xiao, Binyi, additional, Liu, Guochen, additional, Ling, Yihong, additional, Chen, Jiewei, additional, Liu, Zexian, additional, Zuo, Zhixiang, additional, Pan, Zhizhong, additional, Zhou, Penghui, additional, Zheng, Jian, additional, and Ding, Pei-Rong, additional

Published
2021
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47. Inhibition of PARP activity improves therapeutic effect of ARPE-19 transplantation in RCS rats through decreasing photoreceptor death

Author

Gao, Furong, primary, Li, Zongyi, additional, Kang, Ziwei, additional, Liu, Dandan, additional, Li, Peng, additional, Ou, Qingjian, additional, Xu, Jing-Ying, additional, Li, Weiye, additional, Tian, Haibin, additional, Jin, Caixia, additional, Wang, Juan, additional, Zhang, Jieping, additional, Zhang, Jingfa, additional, Lu, Lixia, additional, and Xu, Guo-Tong, additional

Published
2021
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48. BMSC-Derived Exosomes Intervened the Pathogenic Changes of Scleroderma in Mouse Through Its microRNAs

Author

Jin, Jiahui, primary, OU, Qingjian, additional, Wang, Zhe, additional, Tian, Haibin, additional, Xu, Jingying, additional, Gao, Furong, additional, Hu, Shuqin, additional, Chen, Jie, additional, Wang, Juan, additional, Zhang, Jieping, additional, Lu, Lixia, additional, Jin, Caixia, additional, Xu, Guo-Tong, additional, and Zhao, Jingjun, additional

Published
2021
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