38 results on '"Ottoni SL"'
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2. Prospective trial of a uniform protocol for managing infants with neurogenic bladder.
- Author
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Macedo A Jr, Campelo TR, Aragon RG, Macedo EL, Garrone G, Ottoni SL, and Leal da Cruz M
- Subjects
- Humans, Prospective Studies, Female, Male, Infant, Meningomyelocele complications, Meningomyelocele surgery, Clinical Protocols, Infant, Newborn, Urologic Surgical Procedures methods, Follow-Up Studies, Urinary Bladder, Neurogenic surgery, Urinary Bladder, Neurogenic diagnosis, Urinary Bladder, Neurogenic therapy, Urinary Bladder, Neurogenic etiology
- Abstract
Introduction: Since the Management of Myelomeningocele Study (MOMS) publication in 2011 we have designed a prospective protocol for surveillance of neurogenic bladder according to the Leal da Cruz categorization system (J Urol, 2015) that guides us on treatment. Our institution was the precursor of in-utero myelomeningocele (MMC) in Latin America, so our database was biased mostly for patients that underwent fetal surgery for MMC closure. We have demonstrated that in-utero MMC closure does not improve bladder function in opposition to the data from the urological branch of the MOMS study (10), but our control group was based on a historical cohort, before the onset of in-utero MMC repair in our division (15) Since 2018, we have identified an increasing number of referrals of postnatal operated MMC patients to our group just for urological follow up. We decided then to start this prospective protocol for all neurogenic patients and provide a contemporary database to record differences in early bladder function, presence of hydronephrosis and vesicoureteral reflux, treatment, initial outcome and indication of surgery among three mains groups (in-utero MMC repair, post-natal repair and miscellaneous other cases of neurogenic bladder). We want to present preliminary data of this cohort in the period of time 2018 to 2023 (5 years). There was not an exclusion criteria, all patients with neuropathic bladder were included in this study., Materials and Methods: We evaluated our database of all neurogenic bladder (NB) patients aged <1 year who started urological treatment in our institution from 2018. We evaluated diagnosis, age at first visit, clinical data, prevalence of hydronephrosis and (vesicoureteral reflux) VUR, bladder pattern according to the Leal da Cruz categorization system (1), treatment, time of follow-up, number of clinical visits and (urodynamic evaluation) UE performed, final bladder status and surgeries performed., Results: We identified 43 were aged <1 year with a mean age of 4.5 months (median 3.5) at first urological appointment. Diagnosis was myelomeningocele in 33 patients and miscellaneous in 10. From the MMC group, 24 were operated in-utero and 9 post-natal. The initial bladder pattern in the whole group showed 23 (53.5%) high risk, 11 normal (25.6%), 5 underactive bladder (11.6%) and 4 incontinent (9.3%). Mean follow-up was 24 months, mean age at last UE (cases with minimum of 2): 37 months, mean UE per patient: 2. At present, 28 patients perform clean intermittent catheterization (CIC), 23 with anticholinergics and 15 are only under surveillance. VUR was seen in 11/43 cases: 25.6%. Urological surgery has been performed in 4 patients: bladder augmentation in 3 and vesicostomy in 1. Bladder categorization for high-risk and normal patterns were respectively 62.5% and 25% for in utero and 44.4% and 22.2% for postnatal repair and detailed statistical analysis did not present statistical significance of in utero and postnatal groups., Conclusion: Our study can conclude in a contemporary prospective study the findings of elevated incidence of high-risk patterns irrespectively of in-utero or post-natal repair (62.5% and 44.4%). We acknowledge that even though this is not new information and besides the still limited follow up, this cohort is one of the very few that follow and compare in one single institution with comparable UE for in-utero and post-natal MMC repair population, having also a miscellaneous group of NB as a pictorial report of also a similar initial distribution of bladder patterns. We plan to report in the future in a larger cohort the continuation of this study., (Copyright © 2024. Published by Elsevier Ltd.)
- Published
- 2024
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3. Macedo ileal catheterizable reservoir adding the scissors maneuver of channel continence: Long term follow-up.
- Author
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Macedo A Jr, Ottoni SL, Garrone G, Campelo TR, Aragon RG, Macedo EL, and Leal da Cruz M
- Subjects
- Humans, Follow-Up Studies, Male, Female, Ileum surgery, Urinary Catheterization methods, Retrospective Studies, Time Factors, Child, Child, Preschool, Treatment Outcome, Urinary Bladder surgery, Adolescent, Urologic Surgical Procedures methods, Urinary Reservoirs, Continent
- Abstract
Introduction: The Macedo ileal catheterizable channel was published in 2000 and consists of an enterocystoplasty with a catheterizable channel that precludes the need of the appendix for the efferent channel. After 25 years of experience with this technique, we decided to review our experience in a select subgroup of cases performed and followed exclusively by the author in a non-teaching hospital facility after the latest modifications of the procedure., Materials and Methods: Since 2008, we have refined our technique with the following modifications: small skin transverse incision instead of longitudinal one, with a semicircular flap for further stoma creation in the midline and importantly the scissors maneuver. This maneuver consists of crossing two 2 cm rectus abdominis muscle flaps in the midline to create a neosphincter over the catheterizable channel. Follow-up was defined as the interval between the date of surgery and last visit to the clinic. We defined stoma continence if the dry interval between catheterization was 4hs. Early and late complications were reported as well as the reintervention rate. Additional procedures in association with bladder augmentation were also appointed., Results: We have treated 49 patients. Indications were spinal dysraphism (71.4%), mainly myelomeningocele (65.3%), and others (PUV, exstrophy, anorectal anomalies). Urodynamic evaluation showed bladder pressure of high risk for upper urinary tract involvement (66%), urinary incontinence (24.5%), conversion of incontinent urinary diversion (3.8%), one exstrophy patient not considered (1.9%). Mean age at surgery was 88 months (7.3 years), 21 patients had additional surgeries in addition to Macedo ileal catheterizable channel: Macedo-Malone LACE procedure in 21 patients and bladder neck surgery to improve continence in 5 patients. Urinary stoma continence was 93.9% (46/49) after first surgery, one patient had a serous line valve revised, two patients still leak after 2 h and await revision. Overall enterocystoplasty complications rate was 12.24% and consisted of urinary leakage in 3 cases and channel/stoma stricture in 3 cases. All patients treated for sphincteric deficiency associated with bladder reconstruction are continent per urethra. Urinary stoma revision for stricture was done in 2 cases and consisted on suprafascial approach and reanastomosis, one patient resolved with dilatation of the channel to the stoma. Mean follow up is 100 months (8.3 years)., Conclusion: We confirmed in a long term follow-up based on face-to-face visits with 8.3 years mean follow-up that the Macedo procedure associated with the scissors maneuver is associated with 93.9% continence of the stoma. Overall complications rate was 12.24%. The cosmetic aspect with a small transverse incision and a midline stoma is another strength of the technique., (Copyright © 2024 Journal of Pediatric Urology Company. Published by Elsevier Ltd. All rights reserved.)
- Published
- 2024
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4. Myelomeningocele operated in utero and the incontinent bladder pattern: Mid-term follow up of a prospective study.
- Author
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Macedo A Jr, Ottoni SL, Garrone G, Campelo TR, Aragon RG, Correa R, Balladares RJ, Macedo EL, and Leal da Cruz M
- Abstract
Introduction: In-utero myelomeningocele repair is the gold standard treatment after the publication of the MOMS trial. We have performed a retrospective analysis from our prospective in-utero myelomeningocele closure database (started in 2011), and selected only patients with the incontinent bladder pattern according to the Leal da Cruz categorization (Leal da Cruz, et al. J Urol 2015) to review mid-term clinical outcomes., Material and Methods: We identified 30 patients with leaking pressure under 40 cmH20 (incontinent pattern) at first urodynamic evaluation (UE) from the whole cohort of 129 patients who underwent in-utero myelomeningocele closure. We selected patients with a minimum active follow-up of 48 weeks (4 years) to provide mid-term data. Patients were followed according to the same protocol with the proposal of yearly sonogram and UE. All clinical and radiological data were reviewed., Results: We found 11 patients, with a mean age of 10.2 years old, median age at diagnosis of 19 weeks, surgery performed at 25.6 weeks and birth at 33.2 weeks. The mean follow-up was 81.73 months (6.81 years). Mean age at first urological evaluation was 5 months, and UE was 5.6 months. Febrile UTI incidence in the whole observation period was 27.3%. The average initial DLPP was 30 cmH2O. 71.4% of the patients had bladder capacity less than 50% of the expected age. Bladder compliance could not be determined in 63.7% of cases due to leakage. A total of 5.7 urodynamic studies per patient were performed. Surgery was recommended for 8 patients and done in 4 (36.3%). Surgery consisted of Macedo catheterizable reservoir and Macedo-Malone ACE, associated with urethral sling (2 patients) and bladder neck closure (2). It took an average of 5 UE before the final surgical decision was confirmed. Last urodynamic study showed persistent leakage and low DLPP in 3 patients, normal bladder pressure in 2 (under CIC and anticholinergics), and 1 patient changed his bladder pattern into a high risk group. All operated patients are fully continent (urinary >4hs) and fecal., Conclusion: Despite initially presenting a low risk for the most patients, we found surgery in 36.3% (4/11) and if we considered all cases with surgery indication proposed to treat urinary incontinence it would be even higher (72.7%)., (Copyright © 2024 Journal of Pediatric Urology Company. Published by Elsevier Ltd. All rights reserved.)
- Published
- 2024
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5. The GUDplay technique: A shift of paradigm in glans reconstruction for midshaft and penoscrotal hypospadias with moderate chordee. A proposal of a new approach.
- Author
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Macedo A Jr, Ottoni SL, Garrone G, Aragon RG, Campelo TR, Macedo EL, and Leal da Cruz M
- Subjects
- Male, Humans, Child, Preschool, Scrotum surgery, Surgical Flaps, Hypospadias surgery, Urologic Surgical Procedures, Male methods, Penis surgery, Penis abnormalities, Plastic Surgery Procedures methods, Urethra surgery, Urethra abnormalities
- Abstract
Introduction: After 5 years experience with the GUD (glandular urethral disassembly) technique for distal hypospadias, we present the GUDplay technique, incorporating Thiersch-Duplay tubularization of the plate till the coronal area, disassembling the glans aggressively and refurbishing the glans., Methods: We defined the urethral plate and designed an inverted Y incision to open the glans in two wings. The glans was entirely detached from the corpora to gain a great mobility that allowed minor cranial mobilization of the urethra and caudal rotation of the wings. In sequence, there are well-known steps: Duplay urethroplasty, spongioblasts and a Dartos flap to cover the neourethra. The glans was connected to the urethra by 6.0 PDS sutures except in the ventral meatus and the glans wings are joined in the midline., Results: The 5-year-old patient had midshaft hypospadias without previous surgery. The catheter was removed after a week and the healing appears to be good., Discussion: We combined principles of total glans deconstruction in association to Duplay tubularization and then lifted it up to the tip of the glans divided in two wide and mobile wings. We have treated a small series of 6 cases without complications and mean follow-up of 6.2 months., (Copyright © 2024 Journal of Pediatric Urology Company. Published by Elsevier Ltd. All rights reserved.)
- Published
- 2024
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6. Buccal mucosa graft vaginoplasty: A viable option demonstrated step-by-step.
- Author
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Macedo A, Ottoni SL, Jordan Balladares R, Correa R, Garrone G, and Leal da Cruz M
- Subjects
- Adolescent, Humans, Female, Infant, Child, Vagina surgery, Surgical Flaps transplantation, Rectum surgery, Mouth Mucosa transplantation, Plastic Surgery Procedures
- Abstract
Introduction: Persistent cloaca, defined as confluence of the rectum, the vagina and the urethra into a single common channel, has an estimated incidence of 1/50,000 live births. We describe the buccal mucosa graft vaginoplasty for a 11 year old female with cloaca, who underwent at the age of 11 months a Peña repair. We performed the vaginoplasty after the onset of uterine pain due to the beginning of menstruation., Material and Methods: We accessed the lower lip for superficial dissection to harvest the graft. The donor site has been kept with as much submucosal fat as possible to avoid damage to the buccinatoria muscles. A second graft was further obtained from the cheek. Both grafts were submitted to multiple small sections to produce a mesh graft and increase its size. A arciform incision anterior to the anal canal and posterior to the urethra was performed followed by consecutive dissection with eletrocautery to gain profundity. The mesh-graft was placed over the neovaginal cavity and sutured with 4.0 PDS monofilament suture used to suture and then quilt the graft in place. The vaginal capacity was confirmed by ease of a two-digit insertion. Haemostasis was confirmed before the insertion of a soft vaginal mold. The patient remained with an indwelling urinary catheter. The mold was equivalent to 24Fr and had 13 cm of profundity and Foley tube were removed after 14 days postoperatively., Results: Patient had an excellent postoperative course and had been instructed to perform vaginal dilatation every 3 h during the day. Current follow up is 10 months., Discussion: Buccal mucosal grafting has advantages over the use of keratinized skin flaps and intestinal flaps. Buccal mucosa is ideal for female genital reconstruction, given its color, texture, lack of hair and mild mucous production. In our particular case, we connected the neovagina after two months of adequate healing to the native 1⁄3 through laparoscopic approach., Conclusions: BMG vaginoplasty is a viable alternative to treat females with cloaca at adolescence., (Copyright © 2023 Journal of Pediatric Urology Company. Published by Elsevier Ltd. All rights reserved.)
- Published
- 2023
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7. In utero myelomeningocele repair and high-risk bladder pattern. a prospective study.
- Author
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Macedo A Jr, Ottoni SL, Moron A, Cavalheiro S, and da Cruz ML
- Subjects
- Humans, Infant, Prospective Studies, Urinary Bladder surgery, Urodynamics, Meningomyelocele complications, Meningomyelocele surgery, Urinary Bladder, Neurogenic surgery
- Abstract
Objectives: High-risk bladder pattern can be defined by Urodynamic Evaluation (UE) as overactive bladder with detrusor leak point pressure higher than 40 cmH2O and/or higher filling pressures also above 40 cmH2O. We wanted to evaluate response to treatment in myelomeningocele patients operated in utero in this subgroup., Patients and Methods: From our prospective cohort of in utero MMC we have identified patients in the high-risk group. Treatment consisted of anticholinergics (Oxybutynin 0.2 mg/Kg) 2 or 3 times daily in association with CIC. At every UE, patients were reclassified in high-risk or low-risk patterns. Patients not responding were proposed bladder reconstruction or diversion according to age., Results: Between 2011 to 2020, we have been following 121 patients and 60 (49.6%) of them were initially categorized as high-risk. The initial UE was performed at a mean age of 7.9 months and detrusor overactivity was found in 83.3% (mean maximum pressure of 76.5cmH20). When evaluating patients with 2 or more UE, we identified 44 patients (follow-up: 36.8months). It was observed in the group of patients who underwent 2 to 5 UE, that response to treatment was validated by the finding of 40% of low-risk bladder patterns in the second UE and between 62% to 64% in the third to the fifth UE. The incidence of surgery was 13.3%., Conclusions: Early urological treatment of high-risk bladder pattern was effective in approximately 60%. We reinforce the need to correctly treat every patient with myelomeningocele, in accordance with UE, whether undergoing in utero or postnatal treatment., Competing Interests: None declared., (Copyright® by the International Brazilian Journal of Urology.)
- Published
- 2022
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8. Complete diphallia: How to proceed?
- Author
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Macedo A Jr, Ottoni SL, Camilato PCB, Ganchozo HSC, Garrone G, Marcondes RM, and Leal da Cruz M
- Subjects
- Child, Preschool, Humans, Magnetic Resonance Imaging, Male, Penis abnormalities, Penis diagnostic imaging, Penis surgery, Urethra abnormalities, Urethra diagnostic imaging, Urethra surgery, Urinary Bladder, Penile Diseases
- Abstract
Introduction: Diphallia is a rare anomaly. It has a range of appearances from a small accessory penile to complete duplication., Methods: We present a 2 year-old boy with complete penile duplication. The left penile was the largest. NMR (Nuclear Magnetic Resonance) suggested one corporal body for each penile and VCUG (Voiding Cystourethrogram) showed a normal urethra in the right penile and stricture at glandular and mid penile urethra of the left penis. A Y confluence to bulbar urethra was observed confirming only one prostate and bladder., Results: The cystoscopy through the right penile identified the urethral confluence in the bulbar area. We performed a meatotomy in the left penile to insert the cystoscope and confirmed the blind ending urethra. We decided to remove this penile. The penile was degloved entirely and clamped and took out the corpora at the base., Discussion: Diphallia can have three presentations: only glans duplication, bifid diphallia and complete diphallia (two corpora cavernosa and a corpus spongiosum for each penile). In our case, each penile presented only one corpora cavernosa and the decision taken was based on urethral patency., Conclusion: The treatment should always be planned individually whereas associated anomalies with the goal of attaining satisfactory functional and cosmetic results., (Copyright © 2022 Journal of Pediatric Urology Company. Published by Elsevier Ltd. All rights reserved.)
- Published
- 2022
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9. High grade persistent ventral curvature after multiple hypospadias surgery: how to correct?
- Author
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Macedo A Jr, Ottoni SL, Garrone G, and da Cruz ML
- Subjects
- Adolescent, Humans, Infant, Male, Penis surgery, Treatment Outcome, Urethra surgery, Urologic Surgical Procedures, Male methods, Hypospadias surgery, Plastic Surgery Procedures methods
- Abstract
Introduction: A challenging situation in proximal hypospadias is the presentation of patients with successful urethroplasty but with persistent or recurrent ventral curvature (VC) after multiple hypospadias repair., Materials and Methods: We present a 13 year-old boy with 7 previous surgeries (long TIP, Duplay, meatoplasty) to treat hypospadias presenting with 60 degrees of VC, in spite of a well-accepted coronally neomeatus. We degloved the penis and artificial erection clearly appointed corporal disproportion causing curvature. We disconnected urethra from corpora. After excision of remnant fibrotic tissue, there was a residual curvature so a lenghtening corporoplasty with dermal graft from groin was performed. We have adjusted the urethral meatus position into a proximal penile shaft. We used a buccal mucosa graft placed in an inverted U-shape position planning a second stage urethroplasty (1). An indwelling silicone Foley tube was left for one week. The patient was discharged the day after surgery., Results: The aspect after corporoplasty proved satisfactory curvature correction. Patient had an excellent outcome and is scheduled for a second-stage after 6 months., Discussion: Snodgrass and Bush (2) reported that on 73 patients with an average of 2.7 operations for proximal shaft to perineal hypospadias; of which, 83% had VC at re-operation averaging 50°. We do believe that some good results with minimal dorsal plicature may recur in adolescence and therefore when these procedures may be considered, they should be performed by classic Nesbit technique (3). Otherwise, the choice for primary ventral lengthening should be taken., Conclusion: Severe curvature associated with hypospadias should undergo a major procedure at early stage to avoid decompensation after dorsal plicature in adolescence. We had a very satisfactory result, the patient awaits the second stage procedure (Figure-1)., Competing Interests: None declared., (Copyright® by the International Brazilian Journal of Urology.)
- Published
- 2022
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10. The Macedo-Malone antegrade colonic enema: A minimal invasive technique that precludes appendix use.
- Author
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Macedo Júnior A, Garrone G, Ottoni SL, de Mattos RM, and Leal da Cruz M
- Subjects
- Colon, Constipation surgery, Enema methods, Humans, Appendix surgery, Fecal Incontinence surgery
- Abstract
Introduction: Antegrade continence enema (ACE) is recommended for patients with fecal incontinence/constipation refractory to conservative management. The Malone ACE utilizes the appendix as a catheterizable channel whereas the Macedo-Malone (MM) precludes the use of the appendix. We aimed to illustrate the MM procedure., Methods: The left colon is brought out through a small transverse incision on the upper left abdomen and a 3-cm transverse flap in a tenia is created. A 12-Fr silicone Foley catheter is placed on the mucosal surface of the flap to allow creating a tubular conduit. After closure of the anterior wall colonic, the continence valve mechanism is produced by embedding the tube over a serous lined tunnel created by interrupted sutures. The distal portion of the tube is anastomosed into a V shape to the skin flap to avoid stoma stenosis., Discussion: The advantage of this technique is the all-the time availability for not requiring the appendix which some authors prefer to use for urinary reconstruction. In a previous study, we have shown that the MM produces a high rate (89%) of fecal continence (Mean follow-up: 75 months)., Conclusion: We are convinced that this procedure can be incorporated into fecal incontinence/constipation armamentarium., (Copyright © 2021 Journal of Pediatric Urology Company. Published by Elsevier Ltd. All rights reserved.)
- Published
- 2022
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11. In utero myelomeningocele repair and incidence of lower urinary tract surgery. Results of a prospective study.
- Author
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Macedo A Jr, Ottoni SL, Garrone G, Moron A, Cavalheiro S, and Leal da Cruz M
- Subjects
- Child, Preschool, Humans, Incidence, Infant, Prospective Studies, Retrospective Studies, Urodynamics, Meningomyelocele epidemiology, Meningomyelocele surgery, Urinary Bladder
- Abstract
Introduction: The purpose of this study was to determine the incidence of lower urinary tract surgery in patients with myelomeningocele (MMC) operated in utero as well as in the subgroup of patients with a minimum age of 5 years., Methods: We use a previously published protocol to categorize bladder patterns and propose the treatment: high risk pattern-anticholinergics and clean intermittent catheterization (CIC); incontinent and normal patterns-clinical surveillance and underactivity pattern- CIC. Non-response to clinical treatment with maintenance of detrusor pressure higher than 40 cmH20 with worsening of hydronephrosis or recurrent urinary infection were imperative indications for surgery and urinary incontinence due to sphincter deficiency and leakage pressure below 40 cmH20 in patients aged 5 years and older were possible indications too. We identified the prevalence of urinary tract surgery and concomitant treatment of constipation and refractory fecal incontinence by convenience, the technique performed and surgery outcomes., Results: A total of 122 patients are part of the prospective protocol. The first UE was performed in 119 patients (median age of 4 months). The categorization of the bladder pattern was high risk in 52.1%, incontinent in 25.2%, hypocontractile 4.2% and normal in 18.5%. Current follow-up was 29.9 months (1-99 months). Surgery was performed on 10 patients (8.4%): 3 vesicostomies, 2 surgeries to treat vesicoureteral reflux, 6 bladder augmentations, 3 ACE and a sling surgery. Considering only patients older than 5 years, we identified 65 patients and seven surgeries performed (10.8%)., Discussion: Most bladder reconstruction studies are case series of single institutions or cooperative services, most of which are retrospective. The prospective clinical interpretation and imaging and urodynamic exams over time allowed us prospectively to define the risk of surgery in patients with myelomeningocele operated in utero. It must be considered that the response to the initial urological treatment and even the failure that leads to the need for surgery have to be evaluated in a context of follow-up time. For this reason we have studied separately patients over 5 years-old and also the group considered to be at greatest risk for surgery, the high-risk group of the categorization already described., Conclusion: We found an incidence of 10.8% of surgeries in patients over 5 years-old and 12.9% for the high-risk group. This information may be useful to educate parents when stating urological treatment., (Copyright © 2021 Journal of Pediatric Urology Company. Published by Elsevier Ltd. All rights reserved.)
- Published
- 2021
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12. A different approach to distal hypospadias repair: The GUD (glandular urethral disassembly) technique.
- Author
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Macedo A Jr, Ottoni SL, Di Migueli RDD, de Mattos RM, Garrone G, and Leal da Cruz M
- Subjects
- Humans, Infant, Male, Penis surgery, Treatment Outcome, Urethra surgery, Urologic Surgical Procedures, Male, Hypospadias surgery
- Abstract
Introduction: Distal hypospadias represent the most frequent clinical presentation of hypospadias. In spite of more than 300 techniques available, there is not an ideal approach. We have proposed an alternative procedure based on the combination of minor urethral mobilization and major glans deconstruction and partial disassembly from the corpora, the GUD technique. We want to present our clinical experience with the procedure and describe it in detail., Methods: The technique consists of disconnecting the spongious tissue and the distal urethra from the corpora and detaching partially the glans as well, from 2 to 10 o'clock. The glans is opened in midline and the procedure combines cranially mobilization of urethra with caudal and medial rotation of glans wings to refurbish the glans correcting the hypospadia without urethroplasty., Results: We have treated 164 patients with distal hypospadia. Median age at the surgery was 22.4 months (1-184 months). The meatal position after penile degloving was coronal at 108 cases, subcoronal at 54 and 2 patients presented megameatus and intact foreskin. Three patients (1.8%) had mild penoscrotal transposition in addition to hypospadia. Twenty-eight patients were treated as a secondary repair (17%). We found complications in 6 patients (3.6%) consisting of five fistulas (3%) and three glans dehiscence (1.8%). Two patients had both complications. Follow up was 21 months (1-42 months) and the median follow-up time was 18 months., Discussion: We acknowledge that this procedure is intended only to distal hypospadias (coronal and subcoronal). We stress that the GUD procedure can be performed irrespectively of any urethral plate "quality" as it does not require a minimum glans width as the TIP repair. Moreover, there is no need for preoperative testosterone treatment. The absence of suture and urethroplasty minimizes the risk of coronal fistulas after surgery., Conclusions: We believe that this procedure is a viable alternative to distal hypospadias repair., Competing Interests: Conflict of interest None., (Copyright © 2021 Journal of Pediatric Urology Company. Published by Elsevier Ltd. All rights reserved.)
- Published
- 2021
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13. A salvage procedure for redo penile prosthesis implantation in phalloplasty (De castro technique) for congenital aphallia.
- Author
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Macedo A Jr, Ottoni SL, de Castro R, Garrone G, and Leal da Cruz M
- Subjects
- Humans, Male, Patient Satisfaction, Penis surgery, Prosthesis Implantation, Erectile Dysfunction, Penile Diseases, Penile Implantation, Penile Prosthesis, Gender-Affirming Surgery
- Abstract
Introduction: We present a different salvage procedure for penile prosthesis implantation in a De Castro neophallus., Methods: A patient with congenital aphallia had been operated at the age of 11. Ten years later he had two non successful attempts of prosthesis implantation. Surgery consisted of adapting the implants into the aortic graft and folding it in the middle over the cylinders to reinforce its strength., Results: Patient had a successful postoperative course and has now 6 months of follow-up., Discussion: In a systematic review of penile prosthetic outcomes and complications in gender-affirming surgery, most of the prostheses were inflatable (83.6%) and single-cylinder (61.0%). At a mean follow-up of 3.0 years: 36.2% of prosthesis complications, 60.0% of patients had their original implant present and 83.9% reported achieving penetration. We decided to use vascular grafts as a scaffold because of former non successful attempts., Conclusion: The use of vascular prosthesis as a device to implant the penile prosthesis seems to be a safe and effective alternative in an attempt to offer erectile function to the neophallus in case of congenital aphallia., Competing Interests: Conflicts of interest None., (Copyright © 2021 Journal of Pediatric Urology Company. Published by Elsevier Ltd. All rights reserved.)
- Published
- 2021
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14. Conversion of vesicostomy into continent catheterizable reservoirs in myelomeningocele.
- Author
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Macedo A Jr, Ottoni SL, Garrone G, Mattos RM, and da Cruz ML
- Abstract
Competing Interests: None declared.
- Published
- 2021
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15. A simple way to treat penile concealing due to webbed penis.
- Author
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Macedo A Jr, Ottoni SL, Garrone G, de Mattos RM, and da Cruz ML
- Abstract
Competing Interests: None declared.
- Published
- 2021
- Full Text
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16. The GUD technique: glandar urethral disassembly. An alternative for distal hypospadias repair.
- Author
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Macedo A Jr., Ottoni SL, Garrone G, Liguori R, Mattos RM, and da Cruz ML
- Subjects
- Humans, Infant, Male, Penis surgery, Urethra surgery, Urologic Surgical Procedures, Male, Hypospadias surgery, Plastic Surgery Procedures
- Abstract
Introduction: We present an alternative procedure for distal hypospadias consisting of urethral mobilization and partial glandar disassembly, namely GUD (glandar urethral disassembly) technique., Materials and Methods: A subcoronal circumcision exposes distal dysplastic urethra. We incise the Buck´s fascia on both sides of urethra releasing it partially from the corpora. We keep a thin bridge of urethral plate to the glans and disassembly almost completely the glans from the corpora, except for the bridge. The glans is incised creating two wide wings that are extremely mobile. The urethra is mobilized, advanced and sutured to the tip of the glans. The glans wings embrace the distal urethra producing a conical glans., Discussion: Koff et al. published a modification of the Barcat technique known as extensive urethral mobilization and confirmed excellent cosmetic and functional results on 168 patients with only 3.5% of reoperation. This procedure has several modifications but none has reported an aggressive disconnection of corpora to the glans, but simply incising two glans wings. Mitchell & Blagi and Perovic et al. reported on complete penile disassembly for epispadia repair as a way to complete release of the rotation of the penis and treat dorsal chordee. We joined these two procedures to propose the GUD technique. The rationale for this procedure is to avoid suture urethroplasty and create a more conical and cosmetic glans., Conclusion: We are convinced that this operation can be regarded as a genuine alternative to distal hypospadias (coronal and subcoronal) but should not be addressed to midshaft forms., Competing Interests: None declared., (Copyright® by the International Brazilian Journal of Urology.)
- Published
- 2020
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17. Robotic-assisted excision of a prostatic utricle cyst in a 12-month boy with proximal hypospadia and 45X0/ 46XY karyotype.
- Author
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Macedo A Jr, Del Debbio Di Migueli R, Ottoni SL, Leal da Cruz M, and Manzano JP
- Subjects
- Humans, Karyotype, Male, Saccule and Utricle, Urethra, Cysts surgery, Hypospadias genetics, Hypospadias surgery, Robotic Surgical Procedures
- Abstract
Introduction: Prostatic utricle cysts result from incomplete regression of Mullerian duct structures and occur most frequently in males with perineal or peno-scrotal hypospadias. Utricular cysts may present with various signs and symptoms including urinary tract infection, pain and post-void incontinence, a palpable abdominal mass or recurrent epididymitis., Material and Methods: We present a 12 months boy we treated due to proximal hypospadias in two stages, in association to a dysplastic undescended testis that was excised. The karyotype of the patient was 45X0/46XY and after successful hypospadias treatment, the mother complained of purulent discharge in the diapers. A sonogram showed a large cyst behind the bladder with heterogeneous content. The diagnosis of utricle cyst was confirmed by a NMR with detailed anatomy and low confluence of the neck of the cyst to the urethra., Results: We performed a robotic excision of the cyst consisting of careful dissection between bladder and rectum and a safe ligation of the communication of it to the urethra., Conclusion: Patient outcome was uneventful. To the best of our knowledge this is the youngest patient with utricle cyst treated with robotic approach reported in the literature., Competing Interests: Conflicts of interest None., (Copyright © 2020 Journal of Pediatric Urology Company. Published by Elsevier Ltd. All rights reserved.)
- Published
- 2020
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18. The search for continence in bladder exstrophy: Bladder neck transection and Macedo catheterizable reservoir to augment the nativebladder.
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Macedo A Jr, Ottoni SL, Garrone G, Mattos RM, and Leal da Cruz M
- Subjects
- Child, Humans, Male, Retrospective Studies, Urologic Surgical Procedures, Bladder Exstrophy surgery, Urinary Reservoirs, Continent
- Abstract
Introduction: Bladder exstrophy remains one of the most challenging abnormalities in pediatric urology. We propose bladder neck transection and bladder augmentation with a catheterizeable reservoir technique to achieve continence after previous anatomic reconstruction in stages., Methods: At the age of 5-6 years, we offer the transection of bladder neck and enterocystoplasty to achieve continence. We report on a 6-year-old boy that underwent this procedure. We perform the reservoir from ileum according to Macedo-technique that constructs a catheterizeable channel from the same bowel segment. The continence mechanism of the efferent tube is based on angulation and a serous lined tunnel created with 3.0 prolene sutures. The stoma is placed in the midline., Results: Patient had an uneventful evolution and is continent performing CIC every 4 h with 9 months of follow up., Discussion: In spite of continuous development of bladder exstrophy surgery, the urethral continence and voluntary micturition is still not possible in the majority of patients. We discuss with our patients honestly and offer this method as a viable alternative to achieve continence., Conclusion: In our experience, most patients accept urethral transection and suprapubic CIC when educated about results with other alternatives of bladder neck plasty., (Copyright © 2020 Journal of Pediatric Urology Company. Published by Elsevier Ltd. All rights reserved.)
- Published
- 2020
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19. The GUD technique: Glandular urethral disassembly for distal hypospadias repair.
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Macedo A Jr, Ottoni SL, and Leal da Cruz M
- Subjects
- Humans, Infant, Male, Penis surgery, Urethra surgery, Urologic Surgical Procedures, Male, Hypospadias surgery, Plastic Surgery Procedures
- Abstract
Introduction: We present an alternative procedure for distal hypospadias consisting of urethral mobilization and glandular disassembly, named GUD-technique., Material and Methods: After circumcision and exposure of distal dysplastic urethra, it is entirely mobilized from corpora and glans. Glans is deconstructed and incised in midline producing two wings almost not connected to glandular urethra at all. The urethra is then mobilized cranially and sutured to the tip of glans. Glans wings embrace the distal urethra producing a refurbished conical glans., Discussion: Koff et al. published a technique consisting of extensive urethral mobilization for hypospadias repair. Mitchell & Blagi and Perovic et al. reported on complete penile disassembly for epispadia repair as a way to complete release of the rotation of the penis and treat chordee bringing the urethra to a more functional location. We incorporated these two principles in GUD. The rationale is to avoid suture urethroplasty, simply repositioning the mobilized urethra distally and working aggressively on glans disassembly creating a more conical and cosmetic glans. The aggressive deconstruction of glans makes this technique unique., Conclusion: We are convinced that this operation can be regarded as a genuine alternative to distal hypospadias after performing 100 cases in 3 years of experience., (Copyright © 2020 Journal of Pediatric Urology Company. Published by Elsevier Ltd. All rights reserved.)
- Published
- 2020
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20. A Comparative Analysis of Bladder Pattern of Patients who Underwent In Utero Versus Postnatal Myelomeningocele Repair.
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Parizi JLG, Leal da Cruz M, Andrade MC, Garrone G, Ottoni SL, Cavalheiro S, Moron A, and Macedo A Jr
- Subjects
- Female, Humans, Hydronephrosis epidemiology, Infant, Infant, Newborn, Male, Pregnancy, Retrospective Studies, Urinary Tract Infections epidemiology, Vesico-Ureteral Reflux epidemiology, Fetus surgery, Meningomyelocele surgery, Postoperative Complications epidemiology
- Abstract
Purpose: In utero myelomeningocele closure is a valid alternative to postnatal repair with unclear benefits to bladder function. We compared bladder status in patients who underwent fetal myelomeningocele surgery versus postnatal repair., Materials and Methods: We retrospectively reviewed our database, with group 1 consisting of in utero surgery and group 2 consisting of postnatal repair. Group 3 was a subgroup of group 2, including patients initially presenting at age less than 12 months. We recorded medical history, radiological investigation with renal ultrasonography, voiding cystourethrography, urodynamic evaluation and clinical outcome of the bladder pattern after treatment., Results: We identified 88 patients in group 1, 86 in group 2 and 38 in group 3. The incidence of urinary tract infection was higher in the postnatal period (45% vs 20%). Hydronephrosis occurred in 20.7%, 22.6% and 28.9% of patients in groups 1, 2 and 3, respectively. Vesicoureteral reflux was diagnosed in 15% in all groups. Urodynamic data showed a higher prevalence of detrusor overactivity in group 1 and no difference in other urodynamic parameters. The high risk bladder pattern at initial evaluation occurred in 56%, 50% and 46% of patients in groups 1, 2 and 3, respectively. There was a trend to decrease the percentages of the high risk bladder pattern and to increase the normal pattern after treatment in all groups., Conclusions: In utero repair did not improve urological parameters compared to repair in the postnatal period.
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- 2020
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21. In utero myelomeningocoele repair and urological outcomes: the first 100 cases of a prospective analysis. Is there an improvement in bladder function?
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Macedo A Jr, Ottoni SL, Garrone G, Liguori R, Cavalheiro S, Moron A, and Leal Da Cruz M
- Subjects
- Female, Humans, Infant, Infant, Newborn, Meningomyelocele diagnostic imaging, Meningomyelocele embryology, Meningomyelocele surgery, Prospective Studies, Vesico-Ureteral Reflux diagnostic imaging, Vesico-Ureteral Reflux embryology, Fetal Therapies methods, Meningomyelocele physiopathology, Ultrasonography, Prenatal, Urodynamics physiology, Vesico-Ureteral Reflux physiopathology
- Abstract
Objectives: To evaluate the first 100 cases of in utero myelomeningocoele (MMC) repair and urological outcomes in a prospective analysis aiming to define possible improvement in bladder function., Patients and Methods: We used a protocol consisting of a detailed medical history, urinary tract ultrasonography, voiding cystourethrography, and urodynamic evaluation. Patients were categorised into four groups: normal, high risk (overactive bladder with a detrusor leak-point pressure >40 cm H
2 O and high filling pressures also >40 cm H2 O), incontinent, and underactivity (underactive bladder with post-void residual urine), and patients were treated accordingly., Results: We evaluated 100 patients, at a mean age of 5.8 months (median 4 months), classified as high risk in 52.6%, incontinent in 27.4%, with underactive bladder in 4.2%, and only 14.7% had a normal bladder profile. Clean intermittent catheterisation was initiated in 57.3% of the patients and anticholinergics in 52.6%. Antibiotic prophylaxis was initiated in 19.1% of the patients presenting with vesico-ureteric reflux., Conclusion: The high incidence of abnormal bladder patterns suggests little benefit of in utero MMC surgery concerning the urinary tract., (© 2018 The Authors BJU International © 2018 BJU International.)- Published
- 2019
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22. Urinary and Fecal Continence in 5-Year-Old Patients Who Underwent in utero Myelomeningocele Repair: A Prospective Study.
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Macedo A Jr, Cavalheiro S, Moron A, Lobountchenko T, Dini FS, Ottoni SL, Garrone G, Ligori R, and Leal da Cruz M
- Subjects
- Age Factors, Child, Preschool, Databases, Factual, Defecation, Fecal Incontinence physiopathology, Fecal Incontinence therapy, Female, Fetal Therapies adverse effects, Gestational Age, Humans, Male, Meningomyelocele complications, Meningomyelocele diagnostic imaging, Meningomyelocele physiopathology, Prospective Studies, Risk Factors, Treatment Outcome, Ultrasonography, Prenatal, Urinary Incontinence physiopathology, Urinary Incontinence therapy, Urodynamics, Fecal Incontinence etiology, Fetal Therapies methods, Meningomyelocele surgery, Urinary Incontinence etiology, Urogenital Surgical Procedures adverse effects
- Abstract
Introduction: After the successful results of in utero myelomeningocele (MMC) repair presented by the Management of Myelomeningocele Study, the concept of fetal surgery was introduced in our institution in 2011. Since then, we have been able to follow prospectively a group of patients with attention to urological care. In the present study, we were interested in estimating urinary and fecal continence in this new subset of patients., Material and Methods: We selected from our database patients aged 5 years or older for evaluation of urinary and fecal continence. We reviewed all charts and completed a questionnaire to study aspects of urinary and fecal continence., Results: We identified 14 patients, i.e., 4 (28.6%) males and 10 (71.4%) females. The mean age at MMC surgery was 25.6 gestational weeks. The uro-dynamic class was high-risk in 6 (42.9%), incontinent in 4 (28.6%), hypocontractile in 1 (7.1%), and normal in 3 (21.4%) patients. Three patients had undergone surgery (2 augmentations, i.e., 1 in association with a left colon ACE Macedo-Malone procedure and 1 mini-sling urethroplasty). Twelve patients underwent clean intermittent catheterization (CIC) (85.7%). Only 3 (21.4%) patients had no urinary leakage. Eleven patients (78.6%) used diapers. Eight patients (57.2%) underwent retrograde rectal irrigation and 11 (78.6%) complained of fecal loss. Eleven patients (78.6%) did not report an impact on their self-esteem., Conclusion: Despite the use of CIC in 85.7% of the cases, the continence rate in MMC patients operated on in utero was low and 78.6% of the patients used diapers. This data can be used to educate parents about future conditions of their 5-year-old children and may stimulate the debate regarding further attempts (surgical or not) to improve fecal and urinary continence., (© 2019 S. Karger AG, Basel.)
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- 2019
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23. An unusual presentation of urethral duplication presenting with chronic bladder retention, left scrotal transposition and left renal agenesis.
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Macedo A Jr, da Cruz ML, Parizi JLG, Martins GMC, Liguori R, Ottoni SL, Leslie B, and Garrone G
- Subjects
- Chronic Disease, Humans, Hypospadias complications, Infant, Newborn, Kidney surgery, Kidney Diseases complications, Kidney Diseases surgery, Male, Urinary Retention complications, Congenital Abnormalities surgery, Hypospadias surgery, Kidney abnormalities, Kidney Diseases congenital, Urethra abnormalities, Urinary Retention surgery
- Abstract
Introduction and Objective: Urethral duplication is a rare congenital anomaly, with roughly 200 cases reported in the literature (1). It is more frequent in males, with few cases reported in females. The clinical presentation differs according to the anatomical variant present. The duplication most commonly occurs in the sagittal plane with one urethra located ventrally and the other dorsally (2). Usually the ventral urethra is the more functional of both. Duplications occurring in the coronal plane are quite rare and they are usually associated with bladder duplication (3). The purpose of this paper was to present a video of a boy with an unusual urethral duplication form., Materials and Methods: Patient was born premature due to oligohydramnios at 7 months-gestational age and he has initial diagnosis of hypospadia. Since then, he presented at least 7 febrile UTI and mother complained of difficult micturition and a presence of a mass at lower abdomen. Patient was referred to our institution and we identified urethral duplication with a glandar and scrotal meatus, palpable bladder and left penile-hemiscrotum transposition. US and CT-scan showed left kidney agenesis and overdistended bladder. VCUG and retrograde urethrography showed duplication, presence of contrast in the seminal vesicles and complete catheterizing of both urethras was not possible., Results: The topic urethra was dysplastic and not patent to a 4Fr plastic tube so we were unable to access it endoscopically. We performed initially a Mitrofanoff procedure to allow CIC and treat chronic retention. Six months later, we assessed both urethras surgically and concluded that dorsal urethra was dysplastic after 3cm still in the penile area and scrotal urethra was not possible to be catheterized. We excised the ventral urethra because of dribbling complaints up to bulbar area and reconstructed the scrotal transposition, keeping the topic urethra for cosmetic issues. Patient had excellent outcome, performs CIC every 4 hours and has not presented further UTI episodes., Discussion and Conclusion: The urethral duplication is an anomaly that has multiple anatomical presentations. There are several theories about the etiology, but none can explain all types of presentations. There is also more than one rating available, and the Effmann classification is the most detailed. The case exemplifies this varied spectrum of anatomic urethral duplication. It resembles the urethral duplication type IIa-Y, however, ventral urethra meatus was located in penoscrotal area and both urethras were at least partially hypoplastic/dysplastic associated with obstruction and bladder retention. In determining how to best manage a patient with Y-type urethral duplication, the caliber and quality of the orthotopic urethra must first be assessed. Published reports suggest that best outcomes are those using the ventral duplicated urethra for the reconstruction (4). In this case, none of urethras were functional and a supravesical outlet channel had to be provided. The treatment of this condition requires an individualized planning and a vast technical knowledge of reconstructive surgery., Competing Interests: Conflict of interest: None declared., (Copyright® by the International Brazilian Journal of Urology.)
- Published
- 2018
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24. Y-type urethral duplication with rectal implantation of the urethra: Which is the best approach?
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Macedo A Jr, Ottoni SL, Leal da Cruz M, Pompermaier JA, Silva MIS, Liguori R, and Garrone G
- Subjects
- Follow-Up Studies, Humans, Infant, Male, Patient Positioning, Penis surgery, Prone Position, Rare Diseases, Rectum abnormalities, Risk Assessment, Treatment Outcome, Urinary Tract Infections prevention & control, Urogenital Abnormalities diagnosis, Urologic Surgical Procedures, Male methods, Plastic Surgery Procedures methods, Recovery of Function physiology, Rectum surgery, Urethra abnormalities, Urethra surgery, Urogenital Abnormalities surgery
- Abstract
Introduction: Y-type urethral duplication describes the condition in which a functional urethra is implanted in the rectum, and there is also a dysplastic topic urethra which produces mostly urinary dribbling. These patients are at risk of urinary tract complications and UTI. We aimed to present the surgical steps of a case treated by ASTRA approach in which we separated the urethra from the rectum and created a perineal urethrostomy., Material and Methods: We treated a 5-month-old boy with Y-type (IIA-2) urethral duplication, in whom the orthotopic urethra was patent just in the penile segment. The patient had urinary flow per anus and minimal dribbling through the orthotopic urethra. We performed a combined cystoscopy with retrograde urethrogram and managed to catheterize the dysplastic urethra with a guide-wire that showed ectopic implantation in the prostatic urethra, below the bladder neck. We performed an ASTRA procedure to separate the urethra from the rectum. The urethral stump was further mobilized to the perineum and anastomosed to a perineal skin flap to create a stoma and minimize the risk of stricture., Results: The patient was followed at 2 month-intervals, and at 6 months follow-up had an excellent outcome., Conclusion: The ASTRA approach proved to be an excellent alternative for Y-type urethral duplication with functional urethra implanted in the rectum. We believe that further efforts to reconstruct the urethra should be avoided, with a better and simpler option being to create a definitive perineal urethrostomy., (Copyright © 2017 Journal of Pediatric Urology Company. Published by Elsevier Ltd. All rights reserved.)
- Published
- 2018
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25. The anterior sagittal transrectal approach (ASTRA) for cases associated with rectal implantation of the urethra: A retrospective review of six cases.
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Macedo A Jr, Silva MIS, Pompermaier JA, Ottoni SL, de Castro R, and Leal da Cruz M
- Subjects
- Child, Preschool, Humans, Infant, Male, Retrospective Studies, Urologic Surgical Procedures methods, Rectum abnormalities, Rectum surgery, Urethra abnormalities, Urethra surgery
- Abstract
Introduction: Severe genital abnormalities such as urogenital sinus and urethral duplication with ectopic urethra in the rectum represent a major challenge in reconstructive urology., Objective: We aimed to review our cases presenting with functional ectopic urethra implanted in the rectum that were treated through an ASTRA approach., Methods: We reviewed the medical records of all patients who had undergone an ASTRA approach from 2005-2016. We collected data with interest to primary diagnosis, clinical presentation, additional procedure, immediate clinical outcome, complications, bowel habits after surgery, voiding and bladder emptying pattern and long term follow-up., Results: Since 2005, we treated 6 cases using this method, consisting of 3 patients with congenital aphallia and 3 with Y-type urethral duplication. Two aphallia patients underwent De Castro's neophalloplasty with simultaneous anastomosis of proximal urethra to a tubed buccal mucosa neourethra and one had a neophalloplasty with transverse skin flaps and primary perineal urethrostomy. Two patients with Y-type urethral duplication had a complete urethroplasty performed (one end-to-end anastomosis and a two-stage repair). Last patient had a definitive perineal urethrostomy. At mean follow-up of 83.5 meses, only one patient voids through the urethra, four have a Mitrofanoff channel and two have a perineal urethrostomy. Immediate follow-up was uneventful and none of our patients had any bowel complications nor fecal incontinence., Discussion: Domini et al. were the first proponents of the anterior sagittal transanorectal approach (ASTRA) as an alternative to classic Peña approach. Later, De Castro popularized specifically this technique as a relevant part of his neophalloplasty procedure to treat congenital aphallia. We did not find in this series any complications related to ASTRA technique in regards to bowel habits, fecal incontinence or infection but most of cases we tried to create a new anterior urethra and connect to the proximal stump failed. Moreover, we are skeptic to support simultaneous urethral repair when there is a dysplastic bulbar segment between the proximal stump and the end of the penile urethra normally at penoscrotal junction area by urethral duplication. Treatment at two-stages is also prone to fail in the midterm. At end, most of them will have either a Mitrofanoff or perineal urethral stoma as shown in our data., Conclusion: The ASTRA approach proved to be useful for cases of rectal implantation of the urethra. No complications related to anterior sphincter incision were documented. We believe it should be regarded as the treatment of choice for cases alike ours., (Copyright © 2017 Journal of Pediatric Urology Company. Published by Elsevier Ltd. All rights reserved.)
- Published
- 2017
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26. A 4-Year Prospective Urological Assessment of In Utero Myelomeningocele Repair-Does Gestational Age at Birth Have a Role in Later Neurogenic Bladder Pattern?
- Author
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Leal da Cruz M, Liguori R, Garrone G, Ottoni SL, Cavalheiro S, Moron AF, and Macedo A Jr
- Subjects
- Child, Preschool, Female, Gestational Age, Humans, Infant, Infant, Newborn, Infant, Premature, Male, Prospective Studies, Time Factors, Treatment Outcome, Fetus surgery, Meningomyelocele surgery, Urinary Bladder, Neurogenic epidemiology, Urinary Bladder, Neurogenic etiology
- Abstract
Purpose: Premature delivery is a major complication of in utero myelomeningocele repair. The prematurity rate in MOMS (Management of Myelomeningocele Study) was 79%, with a mean gestational age at birth of 34 weeks. We speculated that prematurity could also influence urological outcome in patients operated on prenatally for myelomeningocele., Materials and Methods: Beginning in November 2011, we prospectively followed a population of patients with myelomeningocele who had undergone in utero repair., Results: We compared patients based on gestational age at birth, ie younger than 34 weeks (group 1, 42 patients) and 34 weeks or older (group 2, 37 patients). Mean gestational age at birth was 28.3 weeks (range 25 to 33) in group 1 and 35.2 weeks (34 to 38) in group 2. Of the cases 47.5% in group 1 were classified as high risk, 35% as incontinent, 10% as hypocontractile and 7.5% as normal. By comparison, 54.5% of cases in group 2 were classified as high risk, 33.3% as incontinent and 12.1% as normal. Differences between the groups were not statistically significant. Mean followup was 27.9 months in group 1 and 24.3 months in group 2., Conclusions: Our results show that gestational age at birth has little impact on bladder pattern. These data reinforce the need to follow this population closely., (Copyright © 2017 American Urological Association Education and Research, Inc. Published by Elsevier Inc. All rights reserved.)
- Published
- 2017
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27. Megalourethra and urethrorectal fistula: a rare presentation and a challenging reconstruction.
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Macedo A Jr, Ottoni SL, Parizi JL, Martins GM, Garrone G, and Cruz ML
- Subjects
- Humans, Infant, Male, Reproducibility of Results, Treatment Outcome, Plastic Surgery Procedures methods, Rectal Fistula surgery, Urethra abnormalities, Urethra surgery, Urethral Diseases surgery, Urinary Fistula surgery
- Published
- 2017
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28. Left-colon antegrade enema (LACE): Long-term experience with the Macedo-Malone approach.
- Author
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Anselmo CB, do Amaral RD, Oliveira DE, da Cruz ML, Liguori R, Garrone G, Leslie B, Ottoni SL, Ortiz V, and Macedo A Jr
- Subjects
- Adolescent, Adult, Child, Child, Preschool, Enema adverse effects, Fecal Incontinence etiology, Female, Follow-Up Studies, Humans, Incidence, Male, Meningomyelocele complications, Meningomyelocele surgery, Patient Compliance, Reoperation statistics & numerical data, Retrospective Studies, Treatment Outcome, Young Adult, Colon, Enema methods, Fecal Incontinence therapy
- Abstract
Aims: We evaluated the long-term results with a left antegrade continence enema (LACE) approach: "Macedo-Malone (MM) procedure" to define parameters such as clinical durability of the technique and patients' compliance with the method., Methods: We reviewed the medical records of all patients that underwent the MM procedure in our institution since 2001 and conducted a telephonic interview to investigate the use of the enema and satisfaction with the procedure., Results: Thirty-five MM procedures were performed, but eight patients lost to follow-up were excluded. Fifteen patients (55%) were female. Myelomeningocele was the clinical diagnoses in 25 (93%). Mean age at surgery was 9 years (3-27 years) and mean follow-up was 75 months (median: 56 months). The indication for LACE was clinically intractable constipation with fecal leakage. Most patients still used the stoma regularly to do the enema (74%). Mean washout time was 27 min (2-90 min). The revision rate due to stenosis was 22.2% (6/27) and all underwent suprafascial revision. We performed one classical MACE by infrafascial approach as a salvage procedure. Overall reoperation rate was 25.8% and fecal continence was 89%. There were no reports of leakage through the stoma. Among patients who still used the stoma, 74% were satisfied with surgery and would strongly recommend the procedure to another patient., Conclusions: The MM procedure is a straightforward procedure, which can be performed in 15-20 min, avoids additional entero-entero anastomosis, precludes the use of the appendix, and has shown comparable results to either "classical" MACE or other LACE variants. Neurourol. Urodynam. 36:111-115, 2017. © 2015 Wiley Periodicals, Inc., (© 2015 Wiley Periodicals, Inc.)
- Published
- 2017
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29. Neophalloplasty in boys with aphallia: A systematic review.
- Author
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Oliveira DE, da Cruz ML, Liguori R, Garrone G, Leslie B, Ottoni SL, Souza GR, Ortiz V, de Castro R, and Macedo A Jr
- Subjects
- Child, Humans, Male, Penile Diseases congenital, Penis surgery, Penile Diseases surgery, Penis abnormalities, Plastic Surgery Procedures methods, Urologic Surgical Procedures, Male methods
- Abstract
Objective: Aphallia is a rare penile congenital abnormality. The aim of this systematic review was to assess all available literature on neophalloplasty in infancy with an interest in technical alternatives and clinical outcome., Materials and Methods: We performed a Pubmed search using the terms: neophalloplasty, neophallus, and phalloplasty, and selected articles that presented technical alternatives for penile construction in cases of penile dysgenesis, especially aphallia in children and/or adolescents., Results: A total of 319 articles were identified in the initial search. Among the different techniques presented in 19 papers collected, we categorized reconstructive procedures into two groups: microsurgical and non-microsurgical techniques. Among the microsurgical techniques, procedures such as the osteocutaneous fibular flap (n = 18), the myocutaneous latissimus dorsi flap (n = 24), and the radial forearm free flap (n = 293) were reported. Among the non-microsurgical techniques, we found a wider range of technical options (6 in total). Most were based on groin, abdominal, and scrotal flaps. Long-term reports on the functionability of the neophallus and psychological aspects of the patients are lacking., Conclusion: In assessing recent literature, it seems rational that neophalloplasty should be regarded as the preferred strategy for boys born with aphallia, in opposition to female gender assignment., (Copyright © 2015 Journal of Pediatric Urology Company. Published by Elsevier Ltd. All rights reserved.)
- Published
- 2016
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30. Primary congenital bladder diverticula: Where does the ureter drain?
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Macedo A Jr, Garrone G, Ottoni SL, Oliveira DE, Souza GR, and Cruz ML
- Subjects
- Adolescent, Child, Child, Preschool, Diverticulum diagnosis, Diverticulum physiopathology, Female, Follow-Up Studies, Humans, Infant, Male, Retrospective Studies, Treatment Outcome, Urinary Bladder diagnostic imaging, Urinary Bladder physiopathology, Urography, Cystoscopy methods, Diverticulum surgery, Drainage methods, Urinary Bladder abnormalities, Urinary Bladder surgery, Urodynamics physiology
- Abstract
Background: Primary congenital bladder diverticulum (PCBD) is related to a deficient detrusor layer allowing out-pouching of the bladder mucosa through the inadequate muscularis wall. We aimed to review our experience with symptomatic PCBD in order to correlate clinical findings with anatomical aspects and to present late outcome., Materials and Methods: We reviewed all patients operated in our institution since 2004. We evaluated the charts for complaints, radiological exams, method of treatment, complications and length of follow-up., Results: We treated 10 cases (11 renal units - [RU]), predominantly males (9/10), mean age at surgery of 5.3 years. All patients had significant urological complaints presenting either with antenatal hydronephrosis (4) or febrile urinary tract infection (5) and urinary retention in one. The ureter was found implanted inside the diverticulum in 8/11 RU. An extravesical psoas-hitch ureteroneocystostomy and diverticulum resection was performed in 10/11 cases, whereas 1 case was treated intravesically based on surgeon's preference without performing cystoscopy. Mean follow-up was 34.1 months (1-120) without complications., Conclusions: PCBD is an uncommon diagnosis and has a high probability of drainage inside the diverticulum (72.7%). We recommend the extravesical approach associated with diverticulectomy and ureteroneocystostomy as the preferred technique to treat this abnormality.
- Published
- 2015
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31. Categorization of bladder dynamics and treatment after fetal myelomeningocele repair: first 50 cases prospectively assessed.
- Author
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Leal da Cruz M, Liguori R, Garrone G, Leslie B, Ottoni SL, Carvalheiro S, Moron AF, Ortiz V, and Macedo A Jr
- Subjects
- Fetal Diseases diagnostic imaging, Fetal Diseases physiopathology, Humans, Hydronephrosis diagnostic imaging, Hydronephrosis physiopathology, Hydronephrosis surgery, Prospective Studies, Treatment Outcome, Ultrasonography, Prenatal, Urinary Tract physiopathology, Urodynamics, Fetal Diseases surgery, Meningomyelocele physiopathology, Meningomyelocele surgery, Urinary Bladder physiopathology
- Abstract
Purpose: We categorized bladder patterns and principles of treatment applied to patients who underwent myelomeningocele repair during gestation in a prospective urological assessment., Materials and Methods: We performed urinary tract ultrasound, voiding cystourethrogram and urodynamic evaluation. We then categorized patients into 4 patterns, including normal, high risk (overactive bladder with detrusor leak point pressure greater than 40 cm H2O and high filling pressure also greater than 40 cm H2O), incontinent and underactive bladder., Results: A total of 51 patients were enrolled in study at the first medical appointment. Urodynamic evaluation was done in 48 of these patients as the initial investigation, enabling attribution of a bladder pattern. The high risk pattern was found in 27 patients (56.2%), 18 were incontinent and 1 had an underactive bladder. Only 2 patients (4.2%) in this series had a normal bladder., Conclusions: Of patients who underwent myelomeningocele closure during gestation 93.7% had significant lower urinary tract dysfunction consisting of high bladder pressure or incontinence. These data reinforce the absolute need to follow these patients closely. The potential benefits of fetal surgery in the urinary tract remain to be proved., (Copyright © 2015 American Urological Association Education and Research, Inc. Published by Elsevier Inc. All rights reserved.)
- Published
- 2015
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32. Total urogenital mobilization by CAH: a step-by-step illustration of the technique.
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Macedo A Jr, Leal da Cruz M, Liguori R, Trivelato R, Ottoni SL, Oliveira DE, Souza GR, and Ortiz V
- Subjects
- 46, XX Disorders of Sex Development complications, Adrenal Hyperplasia, Congenital complications, Female, Humans, Infant, 46, XX Disorders of Sex Development surgery, Adrenal Hyperplasia, Congenital surgery, Endoscopy methods, Urogenital Surgical Procedures methods
- Abstract
Introduction: Congenital adrenal hyperplasia (CAH) resulting from deficient 21-hydroxylase activity is an autosomal recessive disorder with an incidence of 1:5000-25,000 in Caucasian populations. Despite various techniques to treat CAH, total urogenital mobilization (TUM) has gained popularity. This technique has low morbidity, and can be performed by the perineal route with the patient in the dorsal lithotomy position without the need to separate the urethra from the vagina. We aim to demonstrate in this video the TUM technique step by step., Methods: A 9-month-old child, born with ambiguous genitalia (Prader 3) with a 46XX karyotype and CAH diagnosis presented to our facility. Endoscopy showed a 2-cm common channel., Results and Discussion: The patient was treated as described in the video and she had an uneventful clinical outcome with complete healing. TUM is an excellent alternative for treating CAH., (Copyright © 2015 Journal of Pediatric Urology Company. Published by Elsevier Ltd. All rights reserved.)
- Published
- 2015
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33. Long-term results with a one-stage complex primary hypospadias repair strategy (the three-in-one technique).
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Macedo A Jr, Liguori R, Ottoni SL, Garrone G, Damazio E, Mattos RM, and Ortiz V
- Subjects
- Anastomosis, Surgical, Humans, Male, Plastic Surgery Procedures methods, Treatment Outcome, Hypospadias surgery, Mouth Mucosa transplantation, Penis surgery, Urologic Surgical Procedures, Male methods
- Abstract
Purpose: Complex primary hypospadias repair that warrants urethral plate division is treated mostly in two steps, not necessarily in two surgeries. Our aim was to review long-term results with a one-stage strategy based on reconstruction of the urethral plate with buccal mucosa graft and onlay transverse preputial flap anastomosis protected by a tunica vaginalis flap (the three-in-one concept)., Material and Methods: We were able to report on 35 patients operated for primary scrotal, penoscrotal and perineal hypospadias between March 2002 and June 2008. We reviewed all charts and had phone interviews with patients not seen for the last 24 months. We investigated parameters such as UTI occurrence, fistula, residual curvature, meatal stenosis, urethral diverticula, dehiscence, orchitis and parental perception., Results: Surgical complications occurred in 13 patients (37%): 4 meatal stenosis, 4 diverticula, 5 fistulae and 2 residual penile curvatures (total 42%). Meatal dilatation was successful in 2 cases, reflected in fistula resolution. The reoperation rate was 31.5% consisting mostly of simple procedures like fistula closure, meatotomy and penile curvature release, and complex diverticula repair in 4 cases. Parental perception was excellent for 57% (20 patients) and good or acceptable for the remaining. Mean follow-up was 4.6 years., Conclusions: The one-step strategy is associated with 68.5% success in a single operation, whereas 31.5% will need a second repair. We recognize that meatal problems are mostly associated with fistulae and diverticula; therefore, we recommend a final acceptable proximal glandar opening that will not compromise the neourethra., (Copyright © 2011 Journal of Pediatric Urology Company. Published by Elsevier Ltd. All rights reserved.)
- Published
- 2011
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34. Bladder hemangiomas and Proteus syndrome: a rare clinical association.
- Author
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Macedo A Jr, Ottoni SL, Barroso U Jr, and Ortiz V
- Subjects
- Child, Female, Humans, Hemangioma complications, Proteus Syndrome complications, Urinary Bladder Neoplasms complications
- Abstract
A case of bladder hemangiomas in association with Proteus syndrome (PS) is described. PS is a rare hamartomatous disorder and comprises an association of verrucous epidermal nevi, infantile hemangiomas, lipoma-like subcutaneous hamartomas and asymmetrical overgrowth of almost any part of the body. To our knowledge, this is the second case reported of hematuria associated with bladder hemangiomas in PS., (Copyright (c) 2009 Journal of Pediatric Urology Company. Published by Elsevier Ltd. All rights reserved.)
- Published
- 2010
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- View/download PDF
35. Is continent urinary diversion feasible in children under five years of age?
- Author
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Barbosa LL, Liguori R, Ottoni SL, Barroso U Jr, Ortiz V, and Macedo A Jr
- Subjects
- Child, Preschool, Feasibility Studies, Female, Humans, Infant, Male, Retrospective Studies, Treatment Outcome, Urinary Diversion adverse effects, Urinary Diversion methods, Urinary Reservoirs, Continent adverse effects
- Abstract
Purpose: To review our clinical experience with urinary continent catheterizable reservoir in children under five years of age., Materials and Methods: A total of 23 patients (16 males, 7 females) with a median age of 3.64 years were evaluated. Among these, 6 (26.08%) had a posterior urethral valve, 9 (39.13%) myelomeningocele, 4 (17.39%) bladder exstrophy, 2 (8.69%) genitourinary rabdomyosarcoma, 1 (4.34%) had spinal tumor and 1 (4.34%) an ano-rectal anomaly., Results: Perioperative complications were observed in four patients consisting of one febrile urinary tract infection, one partial operative wound dehiscence, one partial stomal dehiscence and one vesico-cutaneous fistula after a secondary exstrophy repair. The overall long-term complications rate was 40.90% and consisted of two stomal stenoses (9.09%), one neobladder mucosal extrusion (4.54%), three neobladder calculi (13.63%) and persistence of urinary incontinence in three patients (13.63%). The overall surgical revision was 36.36% and final continence rate was 95.45% with mean follow-up of 39.95 months, Conclusion: Continent urinary diversion is technically feasible even in small children, with acceptable rates of complications.
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- 2009
- Full Text
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36. Transverse testicular ectopia and persistent Müllerian duct syndrome.
- Author
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Macedo A Jr, Barroso U Jr, Ottoni SL, and Ortiz V
- Subjects
- Cryptorchidism diagnostic imaging, Cryptorchidism surgery, Disorders of Sex Development surgery, Hernia, Inguinal surgery, Humans, Infant, Male, Mullerian Ducts pathology, Mullerian Ducts surgery, Scrotum abnormalities, Scrotum diagnostic imaging, Scrotum surgery, Testis diagnostic imaging, Testis surgery, Ultrasonography, Urologic Surgical Procedures, Male, Cryptorchidism pathology, Disorders of Sex Development pathology, Hernia, Inguinal pathology, Mullerian Ducts abnormalities, Testis abnormalities
- Published
- 2009
- Full Text
- View/download PDF
37. Histological evaluation of an alternative method of neophalloplasty based on two lower abdominal skin flaps and simultaneous buccal mucosa graft in the ventral surface of the neophallus (two-stage urethroplasty): experimental study in rabbits.
- Author
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Barbosa LL, Ottoni SL, Sollerman da Costa M, Oliva de Souza P, Venerando da Silva PS, Delcelo R, Ortiz V, de Castro R, and Macedo Júnior A
- Subjects
- Animals, Biopsy, Graft Survival, Male, Models, Animal, Mouth Mucosa cytology, Neovascularization, Physiologic, Penis abnormalities, Rabbits, Rectus Abdominis surgery, Surgical Flaps pathology, Surgical Wound Dehiscence, Transplantation, Autologous, Urethra cytology, Mouth Mucosa transplantation, Penis surgery, Surgical Flaps blood supply, Urethra surgery, Urologic Surgical Procedures, Male methods
- Abstract
Objective: To evaluate, in an experimental study in rabbits, a new model of neophalloplasty based on two lower abdominal skin flaps and ventral buccal mucosa graft for planned two-stage urethroplasty procedure., Material and Methods: Sixteen rabbits were operated and divided into four equal groups which were sacrificed at 2, 4, 8 and 12 weeks. The inflammatory pattern, presence of sub-epithelial fibrosis and epithelial changes in the grafted area were evaluated histologically., Results: There were no deaths and no dehiscence of the wound was seen. One animal in the 2-week group developed an ulcer in the grafted area. We found minimal contracture of the neophallus, but this was not statistically significant between groups. Buccal mucosa graft showed good uptake in all groups, with vascular support from subcutaneous tissue of the flaps. The grafted area developed epithelial metaplasia, showing a decrease in cell layers with time, with disappearance of the sub-epithelial papillae and appearance of stratum granulosum and keratinization of the epithelial graft surface. A decrease in sub-epithelial fibrosis with replacement of immature by mature (eosinophilic) collagen was found. In the later groups was also observed an important decrease in inflammatory response, and the chorion of the grafted area presented a dilated capillary network, indicating that the process of neoangiogenesis was effective., Conclusion: Buccal mucosa displayed histological integration in the abdominal flaps with epithelial metaplasia in all groups. The surgical aspect of the neophallus was cosmetically acceptable, with minimal contracture.
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- 2009
- Full Text
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38. Elective appendicovesicostomy in association with Monfort abdominoplasty in the treatment of prune belly syndrome.
- Author
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Liguori R, Barroso U Jr, Matos JT, Ottoni SL, Garrone G, Demarchi GT, Ortiz V, and Macedo A Jr
- Subjects
- Adolescent, Child, Child, Preschool, Elective Surgical Procedures, Humans, Infant, Male, Patient Satisfaction, Postoperative Complications, Plastic Surgery Procedures, Urinary Catheterization, Urinary Tract Infections prevention & control, Abdominal Muscles surgery, Appendectomy methods, Prune Belly Syndrome surgery, Urinary Diversion methods
- Abstract
Objective: To evaluate the role of elective appendicovesicostomy in association with Monfort abdominoplasty to avoid urinary tract infection (UTI) and renal damage in the post-operative follow-up of patients with prune belly syndrome., Materials and Methods: We followed 4 patients operated in our institution (UNIFESP) (Monfort, orchidopexy and Mitrofanoff) and compared them to 2 patients treated similarly, but without an appendicovesicostomy, in a second institution (UFBA). We evaluated postoperative clinical complications, UTI and preservation of renal parenchyma. Patients were followed as outpatients with urinalysis, ultrasonography (US) and occasionally with renal scintigraphy., Results: Mean follow-up was 23.5 months. Immediate post-operative course was uneventful. We observed that only one patient with the Mitrofanoff channel persisted with UTI, while the 2 patients used as controls persisted with recurrent pyelonephritis (> 2 UTI year)., Conclusion: Our data suggest that no morbidity was added by the appendicovesicostomy to immediate postoperative surgical recovery and that this procedure may have a beneficial effect in reducing postoperative UTI events and their consequences by reducing the postvoid residuals in the early abdominoplasty follow-up. However, we recognize that the series is small and only a longer follow-up with a larger number of patients will allow us to confirm our suppositions. We could not make any statistically significant assumptions regarding differences in renal preservation due to the same limitations.
- Published
- 2006
- Full Text
- View/download PDF
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