228 results on '"Otto, Michael J."'
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2. Molecular Characterization of HIV-2 (ROD) Protease Following PCR Cloning from Virus Infected H9 Cells
3. The Site of Attachment in Human Rhinovirus 14 for Antiviral Agents that Inhibit Uncoating
4. Rational Design of Potent, Bioavailable, Nonpeptide Cyclic Ureas as HIV Protease Inhibitors
5. The Site of Attachment in Human Rhinovirus 14 for Antiviral Agents That Inhibit Uncoating
6. Discovery and Development of PSI-6130/RG7128
7. In vitro Selection of HCV Replicons with Reduced Sensitivity to PSI-352938, A Cyclicphosphate Prodrug of β-d-2′-α-F-2′-β-C-Methylguanosine: 10
8. Synthesis and anti-viral activity of a series of d- and l-2′-deoxy-2′-fluororibonucleosides in the subgenomic HCV replicon system
9. Clevudine: a potent inhibitor of hepatitis B virus in vitro and in vivo
10. New nucleoside reverse transcriptase inhibitors for the treatment of HIV infections
11. Rational design of potent, bioavailable, nonpeptide cyclic ureas as HIV protease inhibitors
12. In vitro susceptibility of clinical isolates of HIV-1 to XM323, a non-peptidyl HIV protease inhibitor
13. Antiviral Activity of Iodinated Pyrimidine Deoxyribonucleosides
14. Overview of the Possible Targets for Viral Chemotherapy
15. β-d-2′-α-F-2′-β-C-Methyl-6-O-substituted 3′,5′-cyclic phosphate nucleotide prodrugs as inhibitors of hepatitis C virus replication: A structure–activity relationship study
16. Inhibition of hepatitis C virus NS5A by fluoro-olefin based γ-turn mimetics
17. Phenylpropenamide derivatives: Anti-hepatitis B virus activity of the Z isomer, SAR and the search for novel analogs
18. The Mechanism of Action of β-d-2′-Deoxy-2′-Fluoro-2′-C-Methylcytidine Involves a Second Metabolic Pathway Leading to β-d-2′-Deoxy-2′-Fluoro-2′-C-Methyluridine 5′-Triphosphate, a Potent Inhibitor of the Hepatitis C Virus RNA-Dependent RNA Polymerase▿
19. Synthesis and anti-HCV activity of 3′,4′-oxetane nucleosides
20. 2′-Deoxy-2′-α-fluoro-2′-β- C-methyl 3′,5′-cyclic phosphate nucleotide prodrug analogs as inhibitors of HCV NS5B polymerase: Discovery of PSI-352938
21. A Rapid Microtiter Assay for Duck Hepatitis Virus Reverse Transcriptase
22. Molecular and Structural Basis for the Roles of Hepatitis C Virus Polymerase NS5B Amino Acids 15, 223, and 321 in Viral Replication and Drug Resistance
23. Inhibition of Human Hepatitis B Virus Replication by AT-61, a Phenylpropenamide Derivative, Alone and in Combination with (−)β-l-2′,3′-Dideoxy-3′-Thiacytidine
24. Development of an in vitro assay for the investgation of metabolism induced drug hepatotoxicity
25. Metabolic Activation of the Anti-Hepatitis C Virus Nucleotide Prodrug PSI-352938
26. Structure of Hepatitis C Virus Polymerase in Complex with Primer-Template RNA
27. Genotype and Subtype Profiling of PSI-7977 as a Nucleotide Inhibitor of Hepatitis C Virus
28. Phosphoramidate Prodrugs of (−)-β-D-(2R,4R)-dioxolane-thymine (DOT) as Potent Anti-HIV Agents
29. Hepatitis C Virus Nucleotide Inhibitors PSI-352938 and PSI-353661 Exhibit a Novel Mechanism of Resistance Requiring Multiple Mutations within Replicon RNA
30. Inhibition of Hepatitis C Virus Replicon RNA Synthesis by PSI-352938, a Cyclic Phosphate Prodrug of β- d -2′-Deoxy-2′-α-Fluoro-2′-β- C -Methylguanosine
31. Discovery of PSI-353661, a Novel Purine Nucleotide Prodrug for the Treatment of HCV Infection
32. Mechanism of Activation of PSI-7851 and Its Diastereoisomer PSI-7977
33. Discovery of a β-d-2′-Deoxy-2′-α-fluoro-2′-β-C-methyluridine Nucleotide Prodrug (PSI-7977) for the Treatment of Hepatitis C Virus
34. PSI-7851, a Pronucleotide of β- d -2′-Deoxy-2′-Fluoro-2′- C -Methyluridine Monophosphate, Is a Potent and Pan-Genotype Inhibitor of Hepatitis C Virus Replication
35. 2-chloro-3-pyridin-3-yl-5,6,7,8-tetrahydroindolizine-1-carboxamide (CMV423), a new lead compound for the treatment of human cytomegalovirus infections
36. The Mechanism of Action of β- d -2′-Deoxy-2′-Fluoro-2′- C -Methylcytidine Involves a Second Metabolic Pathway Leading to β- d -2′-Deoxy-2′-Fluoro-2′- C -Methyluridine 5′-Triphosphate, a Potent Inhibitor of the Hepatitis C Virus RNA-Dependent RNA Polymerase
37. Synthesis and Biological Activity of 5′,9-Anhydro-3-purine-isonucleosides as Potential anti-Hepatitis C Virus Agents.
38. Mechanism of Action of (-)-(2R,4R)-1-(2-hydroxymethyl-1,3-dioxolan-4-yl)thymine as an anti-HIV agent
39. Mechanism of Activation of β- d -2′-Deoxy-2′-Fluoro-2′- C -Methylcytidine and Inhibition of Hepatitis C Virus NS5B RNA Polymerase
40. Clevudine: a potent inhibitor of hepatitis B virusin vitroandin vivo
41. Inhibition of Hepatitis C Replicon RNA Synthesis by β-D-2′-deoxy-2′-fluoro-2′-C-Methylcytidine: A Specific Inhibitor of Hepatitis C Virus Replication
42. Synthesis and antiviral activity of 2′-deoxy-2′-fluoro-2′-C-methyl purine nucleosides as inhibitors of hepatitis C virus RNA replication
43. Synthesis and Structure−Activity Relationships of Novel Anti-hepatitis C Agents: N3,5‘-Cyclo-4-(β-d-ribofuranosyl)-vic-triazolo[4,5-b]pyridin-5-one Derivatives
44. Synthesis and Anti-Hcv Activity of N 9, 5′-Cyclo-3-(β-D-Ribofuranosyl)-8-Azapurin-2-One Derivatives
45. Cytostatic 6-Arylpurine Nucleosides. 6. SAR in Anti-HCV and Cytostatic Activity of Extended Series of 6-Hetarylpurine Ribonucleosides
46. Design, Synthesis, and Antiviral Activity of 2‘-Deoxy-2‘-fluoro-2‘-C-methylcytidine, a Potent Inhibitor of Hepatitis C Virus Replication
47. N 4-Hydroxycytosine Dioxolane Nucleosides and Their Activity Against Hepatitis B Virus
48. SYNTHESIS AND IN VITRO ANTI-HCV ACTIVITY OF β-D- and L-2′-DEOXY-2′-FLUORORIBONUCLEOSIDES
49. Comparative Pharmacokinetics of Racivir®, (±)-β-2′,3′-Dideoxy-5-Fluoro-3′-Thiacytidine in Rats, Rabbits, Dogs, Monkeys and HIV-Infected Humans
50. Synthesis of 5′,9-anhydro-3-(β-d-ribofuranosyl)xanthine, and 3,5′-anhydro-xanthosine as potential anti-hepatitis C virus agents
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