Search

Your search keyword '"Otto, Bradley A."' showing total 486 results
Start Over Author "Otto, Bradley A."
486 results on '"Otto, Bradley A."'

14. How Does Oxymetazoline Change Nasal Aerodynamics and Symptomatology in Patients with Turbinate Hypertrophy?

Author

Root, Zachary T., Lepley, Thomas J., Wu, Zhenxing, Chapman, Robbie J., Schneller, Aspen R., Formanek, Veronica L., Kelly, Kathleen M., Otto, Bradley A., and Zhao, Kai

Abstract

Objectives: Oxymetazoline relieves nasal obstructive symptoms via vasoconstriction, however, the changes in nasal structures and aerodynamics that impact symptoms the most remain unclear. Methods: This prospective, longitudinal, and single blinded cohort study applied Computational Fluid Dynamic (CFD) modeling based on CT scans at baseline and post‐oxymetazoline on 13 consecutive patients with chronic nasal obstruction secondary to inferior turbinate hypertrophy from a tertiary medical center. To account for placebo effect, a sham saline spray was administered with subject blindfolded prior to oxymetazoline, with 30 min rest in between. Nasal Obstruction Symptom Evaluation (NOSE) and unilateral Visual Analogue Scale (VAS) scores of nasal obstructions were collected at baseline, after sham, and 30 min after oxymetazoline. Results: Both VAS and NOSE scores significantly improved from baseline to post‐oxymetazoline (NOSE: 62.3 ± 12.4 to 31.5 ± 22.5, p < 0.01; VAS: 5.27 ± 2.63 to 3.85 ± 2.59, p < 0.05), but not significantly from baseline to post‐sham. The anatomical effects of oxymetazoline were observed broadly throughout the entire length of the inferior and middle turbinates (p < 0.05). Among many variables that changed significantly post‐oxymetazoline, only decreased nasal resistance (spearman r = 0.4, p < 0.05), increased regional flow rates (r = −0.3 to −0.5, p < 0.05) and mucosal cooling heat flux (r = −0.42, p < 0.01) in the inferior but not middle turbinate regions, and nasal valve Wall Shear Stress (WSS r = −0.43, p < 0.05) strongly correlated with symptom improvement. Conclusion: Oxymetazoline broadly affects the inferior and middle turbinates, however, symptomatic improvement appears to be driven more by global nasal resistance and regional increases in airflow rate, mucosal cooling, and WSS, especially near the head of the inferior turbinate. Level of Evidence: 3: Well‐designed, prospective, single blinded cohort trial. Laryngoscope, 134:1100–1106, 2024 [ABSTRACT FROM AUTHOR]

Published
2024
Full Text
View/download PDF

15. Intraoperative Ultrasound-Assisted Endoscopic Endonasal Resection of a Rathke's Cleft Cyst in an Atypical Location: Using a Novel Small Ultrasound Probe.

Author

Khaleghi, Mehdi, Otto, Bradley, Carrau, Ricardo, and Prevedello, Daniel

Subjects
*ENDOSCOPIC surgery, *ENDOSCOPIC ultrasonography, *CYSTS (Pathology), *ULTRASONIC imaging, *INTERNAL carotid artery, *SPHENOID sinus
Abstract

This article discusses the use of intraoperative ultrasound (IUS) as an adjunct to the endoscopic endonasal approach (EEA) for the surgical resection of skull base lesions. The authors present a case study where a novel small-probe IUS was used to assist in the resection of a recurrent Rathke's cleft cyst (RCC) located in an atypical retrosellar region. The small-probe IUS provided real-time imaging feedback and enhanced visualization, allowing for accurate localization of the cyst and surrounding neurovascular structures. The authors conclude that IUS is a promising surgical adjunct that can potentially increase the extent of resection and decrease operation times. [Extracted from the article]

Published
2024
Full Text
View/download PDF

16. Retrosellar Rathke's Cleft Cyst: A Systematic Review of the Literature and Report of a Case.

Author

Khaleghi, Mehdi, Vignolles-Jeong, Joshua, Otto, Bradley, Carrau, Ricardo, and Prevedello, Daniel

Subjects
ARACHNOID cysts, CYSTS (Pathology), PITUITARY gland, PATIENT experience
Abstract

This article provides a systematic literature review of intracranial ectopic Rathke's cleft cysts (RCCs), which are benign congenital lesions located in the sellar and suprasellar regions. The authors present a case of a symptomatic ectopic retrosellar RCC that caused extensive clival erosion. The study includes data on patient demographics, clinical presentation, and treatment details. Surgical approaches varied depending on the cyst's location, and gross total resection was achieved in the majority of cases. The article concludes that further research is needed to better understand the natural history and long-term outcomes of these cysts. [Extracted from the article]

Published
2024
Full Text
View/download PDF

17. Hypothyroidism Following Endoscopic Endonasal Resection of Thyrotropin-Secreting Pituitary Adenoma: A Case Series.

Author

Munjal, Vikas, Carlstrom, Lucas P., Finger, Guilherme, Ghalib, Luma, Kelly, Kathleen, Otto, Bradley A., Carrau, Ricardo, and Prevedello, Daniel M.

Subjects
ENDOSCOPIC surgery, PITUITARY tumors, THYROID gland, HYPOTHYROIDISM, RHINORRHEA, THYROTROPIN receptors, THYROID gland function tests
Abstract

This article discusses the occurrence of hypothyroidism following endoscopic endonasal resection of thyrotropin-secreting pituitary adenomas (TSHomas). The study conducted a retrospective review of patients who underwent this surgical procedure and found that postoperative hypothyroidism was a common outcome. The article emphasizes the importance of recognizing this potential outcome for appropriate postoperative management and patient counseling. The authors suggest that further research and larger case series are needed to gain more insights into the mechanism and peri-operative management of these patients. [Extracted from the article]

Published
2024
Full Text
View/download PDF

19. 3D Printing as a Planning Tool to Optimize Sinonasal Irrigation.

Author

Lepley, Thomas J., Kim, Kanghyun, Ardizzone, Melissa, Kelly, Kathleen M., Otto, Bradley A., and Zhao, Kai

Subjects
EVALUATION of medical care, MAXILLARY sinus, NASAL irrigation, PARANASAL sinuses, SPHENOID sinus, HEAD, SINUSITIS, RESEARCH funding, THREE-dimensional printing
Abstract

Background: Topical sinus irrigation plays a critical role in the management of sinonasal diseases. Yet, the penetration of irrigant to targeted sinuses may be highly variable and difficult to predict. Here, we investigate the use of 3D printing as a planning tool to optimize outcomes. Methods: Eight post-operative models were 3D printed with a FormLabs Form3 printer based on individual CT scans. Irrigations were performed and video recorded with a squeeze bottle attached via silicon water-tight seal, in 4 head positions: 45° to-the-side, 90° to-the-side, 45° forward and 45° to-the-side, and 90° forward, with irrigation fluid entering the upper (conventional) or lower (backfill) nostrils. Results: Significant individual variations were observed in sinus penetration as a function of head position. In general, the maxillary sinus was the easiest to irrigate in most head positions (P <.05), followed by frontal and ethmoid, with sphenoid being the most difficult. Both the 90°-to-the-side and the 90°-forward positions were significantly more effective than the others (P <.05), with 90°-forward better for frontal sinuses and 90°-to-the-side superior for all other sinuses. The backfill was significantly superior to conventional technique in head positions involving a side tilt (P <.05). Conclusion: Variations in technique and position significantly impacted irrigation outcome. Backfill irrigation that pushes fluid against gravity to pool around the ostium, seems to provide overall better outcomes. This study demonstrates the advantage of 3D printing as a rapid planning tool to guide irrigation strategies. [ABSTRACT FROM AUTHOR]

Published
2023
Full Text
View/download PDF

22. Nasoseptal Flap Skills Training Using 3D Simulation and a Cadaveric Model

Author

Naksen, Pakjira, additional, Sirirungreung, Anupong, additional, Kantiwong, Anupong, additional, Salem, Eman H., additional, Alsavaf, Mohammad Bilal, additional, Fadel, Michael, additional, Otto, Bradley A., additional, VanKoevering, Kyle K., additional, Prasittivatechakool, Kajohnkiat, additional, and Carrau, Ricardo L., additional

Published
2023
Full Text
View/download PDF

25. Intraoperative Predictor of Remission in Cushing Disease

Author

Zachariah, Marcus A., primary, Cua, Santino, additional, Muhlestein, Whitney E., additional, Otto, Bradley A., additional, Carrau, Ricardo L., additional, Kirschner, Lawrence S., additional, Ghalib, Luma M., additional, Lonser, Russell R., additional, Hardesty, Douglas A., additional, and Prevedello, Daniel M., additional

Published
2022
Full Text
View/download PDF

27. International Tuberculum Sellae Meningioma Study: Preoperative Grading Scale to Predict Outcomes and Propensity-Matched Outcomes by Endonasal Versus Transcranial Approach

Author

Magill, Stephen T., Schwartz, Theodore H., Couldwell, William T., Gardner, Paul A., Heilman, Carl B., Sen, Chandranath, Akagami, Ryojo, Cappabianca, Paolo, Prevedello, Daniel M., McDermott, Michael W., Przybylowski, Colin J., Almefty, Kaith K., Patel, Akash J., Khan, A. Basit, Wu, Kyle C., Bi, Wenya Linda, Dunn, Ian F., Mamelak, Adam N., Ehsan, Mohammad U., Bruce, Jeffrey N., Englander, Zachary K., Wang, Linda M., Youngerman, Brett, Anand, Vijay K., Kacker, Ashutosh, Tabaee, Abtin, Clarke, David B., Walling, Simon A., Hebb, Andrea L. O., Macki, Mohamed, Anand, Sharath K., Rock, Jack P., Baskin, David S., Yewah Gwei, Larisse K., Guthikonda, Bharat, Kosty, Jennifer, Nanda, Anil, Sun, Hai, Culicchia, Frank, Morrow, Kevin, Fannin, Erin, Germanwala, Anand V., Prabhu, Vikram C., Patel, Chirag R., Chaichana, Kaisorn, Quinones-Hinojosa, Alfredo, ReFaey, Karim, Chandler, James P., Fernandez, Luis G., Oyon, Daniel E., Youngblood, Mark W., Golfinos, John G., Placantonakis, Dimitris G., Pacione, Donato, Delavari, Nader, Albonette-Felicio, Thiago, Otto, Bradley A., Carrau, Ricardo L., Han, Seunggu J., Shahin, Maryam N., Brahimaj, Bledi C., Beer-Furlan, André, Byrne, Richard W., Munich, Stephan A., Munoz, Lorenzo F., Liu, James K., Zhao, Kevin, Agarwalla, Pankaj K., Hsueh, Wayne D., Eloy, Jean Anderson, Chang, Steven D., Meola, Antonio, Teng, Hao, Goulart, Carlos R., Rai, Shawn S., Chin, Lawrence S., Ahye, Nicholas, Weaver, Michael, Mangham, William M., Michael, L. Madison, Robertson, Jon H., Dowd, Richard S., Amenta, Peter S., Scullen, Tyler A., de Divitiis, Oreste, Solari, Domenico, Cavallo, Luigi M., Makarenko, Serge, Rizzuto, Michael, Prakash, Swetha, Chen, William C., El-Sayed, Ivan H., Nguyen, Minh P., Morshed, Ramin A., Theodosopoulos, Philip V., Aghi, Manish K., Santarius, Thomas, Stastna, Daniela, Williams, Brian J., Andaluz, Norberto, Adappa, Nithin D., Palmer, James N., Grady, M. Sean, Lee, John Y. K., Buch, Love, Sharma, Nikhil, Joshi, Disha, Champagne, Pierre-Olivier, Valappil, Benita, Kumar, Jay I., Agarwalla, Pankaj K., Agazzi, Siviero, van Loveren, Harry, Zada, Gabriel, Strickland, Benjamin, Garrett, Norman E., Plitt, Aaron R., Barnett, Samuel L., Mickey, Bruce E., Garzon-Muvdi, Tomas, Nassiri, Farshad, Gentili, Fred, Kalyvas, Aristotelis, Zadeh, Gelareh, Karsy, Michael, Sayyahmelli, Sima, Baskaya, Mustafa K., Morone, Peter J., Cavallo, Claudio, Sylvester, Peter T., and Chicoine, Michael R.

Published
2023
Full Text
View/download PDF

28. International Tuberculum Sellae Meningioma Study: Surgical Outcomes and Management Trends

Author

Magill, Stephen T., Schwartz, Theodore H., Couldwell, William T., Gardner, Paul A., Heilman, Carl B., Sen, Chandranath, Akagami, Ryojo, Cappabianca, Paolo, Prevedello, Daniel M., McDermott, Michael W., Przybylowski, Colin J., Almefty, Kaith K., Patel, Akash J., Khan, A. Basit, Wu, Kyle C., Bi, Wenya Linda, Dunn, Ian F., Mamelak, Adam N., Ehsan, Mohammad U., Bruce, Jeffrey N., Englander, Zachary K., Wang, Linda M., Youngerman, Brett, Anand, Vijay K., Kacker, Ashutosh, Tabaee, Abtin, Clarke, David B., Walling, Simon A., Hebb, Andrea L. O., Macki, Mohamed, Anand, Sharath K., Rock, Jack P., Baskin, David S., Yewah Gwei, Larisse K., Guthikonda, Bharat, Kosty, Jennifer, Nanda, Anil, Sun, Hai, Culicchia, Frank, Morrow, Kevin, Fannin, Erin, Germanwala, Anand V., Prabhu, Vikram C., Patel, Chirag R., Chaichana, Kaisorn, Quinones-Hinojosa, Alfredo, ReFaey, Karim, Chandler, James P., Fernandez, Luis G., Oyon, Daniel E., Youngblood, Mark W., Golfinos, John G., Placantonakis, Dimitris G., Pacione, Donato, Delavari, Nader, Albonette-Felicio, Thiago, Otto, Bradley A., Carrau, Ricardo L., Han, Seunggu J., Shahin, Maryam N., Brahimaj, Bledi C., Beer-Furlan, André, Byrne, Richard W., Munich, Stephan A., Munoz, Lorenzo F., Liu, James K., Zhao, Kevin, Agarwalla, Pankaj K., Hsueh, Wayne D., Eloy, Jean Anderson, Chang, Steven D., Meola, Antonio, Teng, Hao, Goulart, Carlos R., Rai, Shawn S., Chin, Lawrence S., Ahye, Nicholas, Weaver, Michael, Mangham, William M., Michael, L. Madison, Robertson, Jon H., Dowd, Richard S., Amenta, Peter S., Scullen, Tyler A., de Divitiis, Oreste, Solari, Domenico, Cavallo, Luigi M., Makarenko, Serge, Rizzuto, Michael, Prakash, Swetha, Chen, William C., El-Sayed, Ivan H., Nguyen, Minh P., Morshed, Ramin A., Theodosopoulos, Philip V., Aghi, Manish K., Santarius, Thomas, Stastna, Daniela, Williams, Brian J., Andaluz, Norberto, Adappa, Nithin D., Palmer, James N., Grady, M. Sean, Lee, John Y. K., Buch, Love, Sharma, Nikhil, Joshi, Disha, Champagne, Pierre-Olivier, Valappil, Benita, Kumar, Jay I., Agarwalla, Pankaj K., Agazzi, Siviero, van Loveren, Harry, Zada, Gabriel, Strickland, Benjamin, Garrett, Norman E., Plitt, Aaron R., Barnett, Samuel L., Mickey, Bruce E., Garzon-Muvdi, Tomas, Nassiri, Farshad, Gentili, Fred, Kalyvas, Aristotelis, Zadeh, Gelareh, Neurosurgery, Division of, Hospital, Toronto Western, Toronto, University of, Toronto, Ontario, Karsy, Canada; Michael, Sayyahmelli, Sima, Baskaya, Mustafa K., Morone, Peter J., Cavallo, Claudio, Sylvester, Peter T., and Chicoine, Michael R.

Published
2023
Full Text
View/download PDF

35. Machine Learning–Based Analysis and Prediction of Unplanned 30-Day Readmissions After Pituitary Adenoma Resection: A Multi-Institutional Retrospective Study With External Validation

Author

Crabb, Brendan T., primary, Hamrick, Forrest, additional, Campbell, Justin M., additional, Vignolles-Jeong, Joshua, additional, Magill, Stephen T., additional, Prevedello, Daniel M., additional, Carrau, Ricardo L., additional, Otto, Bradley A., additional, Hardesty, Douglas A., additional, Couldwell, William T., additional, and Karsy, Michael, additional

Published
2022
Full Text
View/download PDF

41. List of Contributors

Author

Abdo do Seixo Kadri, Paulo, primary, Adamo, Matthew A., additional, Adamski, Jennifer, additional, Al-Mefty, Osama, additional, Ali, Arif N., additional, Aquilina, Kristian, additional, Balogun, James A., additional, Barkhoudarian, Garni, additional, Bartels, Ute, additional, Bi, Wenya Linda, additional, Bouffet, Eric, additional, Bradley, Julie A., additional, Brem, Henry, additional, Cappabianca, Paolo, additional, Carrau, Ricardo L., additional, Couldwell, William T., additional, Curran, Walter J., additional, Del Basso De Caro, Maria Laura, additional, Ding, Dale, additional, Di Somma, Alberto, additional, Ditzel Filho, Leo F.S., additional, Dlouhy, Brian J., additional, Dunn, Ian F., additional, Evans, James J., additional, Ferreira, Manuel, additional, Friedman, David P., additional, Funaki, Takeshi, additional, Gandhe, Ashish R., additional, Gandhi, Ravi H., additional, Gooch, M. Reid, additional, Indelicato, Daniel J., additional, Jallo, George, additional, Jamshidi, Ali O., additional, Jane, John, additional, Jimenez, Rachel, additional, Jones, David, additional, Kelly, Daniel F., additional, Kenning, Tyler J., additional, Kerr, Edward E., additional, Kim, Irene, additional, Klibanski, Anne, additional, Kondziolka, Douglas, additional, Krisht, Khaled M., additional, Laws, Edward R., additional, Lee, Cheng-Chia, additional, Louis, Robert G., additional, Lunsford, L. Dade, additional, MacDonald, Shannon M., additional, Mantovani, Alessandra, additional, Margetis, Konstantinos, additional, Maria Cavallo, Luigi, additional, Martins, Carolina, additional, McCrea, Heather J., additional, Mehta, Gautam U., additional, Monaco, Edward A., additional, Müller, Hermann L., additional, Niranjan, Ajay, additional, Niu, Guilian, additional, Oldfield, Edward H., additional, Otto, Bradley A., additional, Payner, Troy D., additional, Peris-Celda, Maria, additional, Pinheiro-Neto, Carlos D., additional, Prevedello, Daniel M., additional, Qian, Jiang, additional, Rhoton, Albert L., additional, Rubin, Benjamin A., additional, Rutka, James T., additional, Schwartz, Theodore H., additional, Sekhar, Laligam N., additional, Sergott, Robert C., additional, Sethi, Roshan V., additional, Sheehan, Jason P., additional, Shekhtman, Eugenia, additional, Sivakumar, Walavan, additional, Solari, Domenico, additional, Souweidane, Mark, additional, Tempel, Zachary, additional, Teo, Charles, additional, Theodosopoulos, Philip V., additional, Thompson, Dominic, additional, Tritos, Nicholas A., additional, Uribe, Rafael, additional, Valentine, Rowan, additional, Wen, Hung Tzu, additional, Wisoff, Jeffrey H., additional, Yachnis, Anthony T., additional, and Yang, Tong, additional

Published
2015
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results