Search

Your search keyword '"Ottenbrite, R. M."' showing total 49 results
Start Over Author "Ottenbrite, R. M."
49 results on '"Ottenbrite, R. M."'

14. Preparation of Polyimides Utilizing the Diels−Alder Reaction. 1,4-[N,N‘-Bis(butadienyl-2-methyl)diamido]-2,3,5,6- tetramethylbenzenes with Bismaleimides

Author

Smith, J. G., Jr., Sun, F., and Ottenbrite, R. M.

Abstract

Bis(amide-1,3-diene) monomers were prepared from 1,4-[N,N‘- bis(butadienyl-2-methyl)diamino]-2,3,5,6-tetramethylbenzene and several alkyl and aryl acid chlorides. The corresponding poly(amide imide)s were prepared by the Diels−Alder reaction involving these bis(amide-1,3-diene)s with bismaleimides. The polymers exhibited inherent viscosities of 0.21−0.81 dL/g and glass transition temperatures ranging from 202 to 269 °C. Moderate thermal stability was observed by dynamic thermogravimetric analysis, with 10% weight loss occurring between 318 and 350 °C in helium. The polymers were soluble in N,N-dimethylacetamide and chlorinated solvents. Creasable films were obtained by solution casting from chloroform. The chemistry and physical properties of the monomers and polymers are discussed.

Published
1996

25. Kobunshi

Author

Donaruma, L. Guy, primary, Ottenbrite, R. M., additional, and Vogl, Otto, additional

Published
1980
Full Text
View/download PDF

43. Biological activity of maleic anhydride copolymers. I. Biocompatibility and antitumoural effects of maleic anhydride-vinyl acetate, maleic anhydride-methyl methacrylate and maleic anhydride-styrene copolymers.

Author

Uglea CV, Panaitescu L, Spridon D, Ursu D, Popa I, and Ottenbrite RM

Subjects
Animals, Antineoplastic Agents chemistry, Antineoplastic Agents toxicity, Biocompatible Materials chemistry, Biocompatible Materials toxicity, Carcinoma 256, Walker drug therapy, Cell Death drug effects, Humans, Male, Maleates chemistry, Maleates pharmacology, Maleates toxicity, Maleic Anhydrides chemistry, Maleic Anhydrides toxicity, Materials Testing, Methylmethacrylates chemistry, Methylmethacrylates pharmacology, Methylmethacrylates toxicity, Molecular Weight, Organ Size drug effects, Polymers chemistry, Polymers toxicity, Polystyrenes chemistry, Polystyrenes pharmacology, Polystyrenes toxicity, Polyvinyls chemistry, Polyvinyls pharmacology, Polyvinyls toxicity, Rats, Rats, Wistar, Tumor Cells, Cultured, Antineoplastic Agents pharmacology, Biocompatible Materials pharmacology, Maleic Anhydrides pharmacology, Polymers pharmacology
Abstract

A series of maleic anhydride (MA)-vinyl acetate (VA), MA-methyl methacrylate (MM), and MA-styrene (S) copolymers were prepared and characterized. On employing various amounts of initiator, maleic anhydride-vinyl acetate, methyl methacrylate, and styrene copolymers with molecular weights ranging between 18,000 and 200,000 have been obtained. The in vivo and in vitro tests performed on K562 cellular cultures (human chronic myeloid leukemia) have shown that, as a function of the molecular weight, the synthesized copolymers demonstrate a 50% in vitro cytotoxicity and an average tumour regression of maximum 68%.

Published
1996
Full Text
View/download PDF

44. Drug delivery systems based on inorganic materials: I. Synthesis and characterization of a zeolite-cyclophosphamide system.

Author

Uglea CV, Albu I, Vătăjanu A, Croitoru M, Antoniu S, Panaitescu L, and Ottenbrite RM

Subjects
Animals, Carcinoma 256, Walker drug therapy, Male, Rats, Rats, Wistar, Antineoplastic Agents administration & dosage, Cyclophosphamide administration & dosage, Drug Delivery Systems, Materials Testing, Zeolites chemistry
Abstract

Porous material of the CuX zeolite type has been synthesized and used as support for a classic antitumoral drug--cyclophosphamide (CP). The new material obtained represents a physical mixture of the two components. In vivo tests allowed biochemical and anatomopathological evaluation of antitumoral effects determined by oral administration of the CuX zeolite-CP system. Data obtained show that the intensity of the antitumoral effects of the CuX zeolite-CP system is similar as compared to that achieved by CP. A possible advantage of the CuX zeolite-CP system is the continual maintenance in the blood of a CP concentration ranging between 100 and 1,000 ng ml-1 plasma.

Published
1994
Full Text
View/download PDF

46. Some biologically active copolymers of maleic anhydride.

Author

Ottenbrite RM and Kaplan AM

Subjects
Animals, Carcinoma, Ehrlich Tumor drug therapy, Cytotoxicity, Immunologic drug effects, Mice, Molecular Weight, Polymers, Pyran Copolymer pharmacology, Structure-Activity Relationship, Antineoplastic Agents, Furans pharmacology, Macrophage Activation drug effects, Maleic Anhydrides pharmacology
Published
1985
Full Text
View/download PDF

47. Macrophage activation and antitumor activity of cyclohexyl-1,3-dioxepin and 4-methyl-2-pentonyl maleic anhydride copolymers.

Author

Kaplan AM, Kuus K, and Ottenbrite RM

Subjects
Animals, Ascites pathology, Blood Cell Count, Cytotoxicity, Immunologic drug effects, Female, Macrophages enzymology, Mice, Mice, Inbred C57BL, Molecular Weight, Neoplasms, Experimental drug therapy, Peroxidases metabolism, Polyelectrolytes, Structure-Activity Relationship, Antineoplastic Agents, Furans pharmacology, Macrophage Activation drug effects, Macrophages drug effects, Maleic Anhydrides pharmacology, Polymers pharmacology
Published
1985
Full Text
View/download PDF

48. In situ activation of murine peritoneal macrophages by cyclohexyl-1,3-dioxepin and 4-methyl-2-pentenoyl maleic anhydride copolymers.

Author

Kuus K, Ottenbrite RM, and Kaplan AM

Subjects
5'-Nucleotidase, Animals, Cytotoxicity, Immunologic drug effects, Female, Immunotherapy, Leukocytes drug effects, Lung Neoplasms therapy, Macrophages physiology, Mice, Mice, Inbred C57BL, Nucleotidases metabolism, Peroxidases metabolism, Macrophage Activation drug effects, Polymers pharmacology
Abstract

Peritoneal macrophages (PM theta) from mice treated intraperitoneally with the unique polyanionic compounds cyclohexyl-1,3-dioxepin maleic anhydride copolymer (CDA-MA) and 4-methyl-2-pentenoyl maleic anhydride copolymer (MP-MA) had tumoricidal activity against Lewis lung tumor cells. 5'-Nucleotidase ectoenzyme activity, which had previously been associated only with nontumoricidal, resident PM theta, was elevated in tumoricidal PM theta elicited with CDA-MA and MP-MA. Cell counts and differentials performed on peripheral blood leukocytes and PM theta populations from CDA-MA- and MP-MA--treated mice more closely corresponded to those of normal mice than mice treated with the conventional PM theta-activating agents pyran and Corynebacterium parvum. In addition, the lysosomal peroxidase activity in PM theta after administration of CDA-MA and MP-MA remained at levels comparable with normal resident PM theta, while an influx of peroxidase-positive macrophages was observed after administration of pyran and C. parvum. Inoculation of CDA-MA and MP-MA into mice bearing Lewis lung carcinoma showed a significant increase in median survival time compared with control mice, as well as an increase in the percentage of mice that survived greater than 90 days. Taken together, these data suggest that CDA-MA and MP-MA activated PM theta in situ and prolonged survival against primary transplanted Lewis lung carcinoma.

Published
1985

49. Polymaleic anhydride: effects on the immune system and Friend leukemia disease of mice.

Author

Goodell EM, Ottenbrite RM, and Munson AE

Subjects
Animals, Friend murine leukemia virus, Hypersensitivity, Delayed immunology, Leukemia, Experimental immunology, Male, Mice, Phagocytosis drug effects, Antibody Formation drug effects, Furans analogs & derivatives, Furans pharmacology, Furans therapeutic use, Immunity, Cellular drug effects, Leukemia, Experimental prevention & control, Maleic Anhydrides analogs & derivatives, Maleic Anhydrides pharmacology, Maleic Anhydrides therapeutic use, Polymers pharmacology, Polymers therapeutic use
Published
1978

Catalog

Books, media, physical & digital resources
See catalog results