30 results on '"Otoshi R"'
Search Results
2. Impact of Deep-learning-based Lung Imaging Analysis for Estimation of Pulmonary Hypertension in Idiopathic Pulmonary Fibrosis
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Fujimoto, K., primary, Kitamura, H., additional, Tagami, Y., additional, Otoshi, R., additional, Niwa, T., additional, Baba, T., additional, Okudela, K., additional, Ito, K., additional, Iwasawa, T., additional, Natsume, Y., additional, and Ogura, T., additional
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- 2024
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3. Direct Comparison Between Pathological Diagnosis of Cryobiopsy and Surgical Lung Biopsy for Interstitial Lung Disease
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Baba, T., primary, Takemura, T., additional, Okudela, K., additional, Asaoka, M., additional, Katano, T., additional, Matama, G., additional, Aiko, N., additional, Isomoto, K., additional, Horio, Y., additional, Uchida, Y., additional, Otoshi, R., additional, Tabata, E., additional, Shintani, R., additional, Okabayashi, H., additional, Ikeda, S., additional, Niwa, T., additional, Oda, T., additional, Okuda, R., additional, Sekine, A., additional, Kitamura, H., additional, Komatsu, S., additional, Hagiwara, E., additional, and Ogura, T., additional
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- 2019
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4. Low Starting-Dosage Reduce the Early Termination of Nintedanib in Patients with Idiopathic Pulmonary Fibrosis
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Ikeda, S., primary, Sekine, A., additional, Baba, T., additional, Katano, T., additional, Matama, G., additional, Aiko, N., additional, Isomoto, K., additional, Otoshi, R., additional, Tabata, E., additional, Shintani, R., additional, Niwa, T., additional, Oda, T., additional, Okuda, R., additional, Kitamura, H., additional, and Ogura, T., additional
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- 2019
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5. Drug-related pneumonitis caused by amikacin liposome inhalation suspension: One pathologically proven case and single-center experience.
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Kaneko T, Otoshi R, Sekine A, Baba T, Yamada C, Haga S, Tagami Y, Sawazumi T, Takemura T, Komatsu S, Hagiwara E, and Ogura T
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- Humans, Male, Administration, Inhalation, Aged, Female, Retrospective Studies, Middle Aged, Suspensions, Tomography, X-Ray Computed, Alveolitis, Extrinsic Allergic chemically induced, Leukocyte Count, Anti-Bacterial Agents administration & dosage, Anti-Bacterial Agents adverse effects, Acute Lung Injury etiology, Acute Lung Injury diagnostic imaging, Amikacin administration & dosage, Amikacin adverse effects, Liposomes, Eosinophils pathology
- Abstract
Amikacin liposome inhalation suspension (ALIS) is known to cause drug-related pneumonitis, which has been described as "hypersensitivity pneumonitis (HP)". However, its clinical and pathological characteristics have never been reported. We retrospectively evaluated 18 patients treated with ALIS. Three (16.7%) patients developed HP-pattern pneumonitis on high-resolution computed tomography. Serum eosinophil counts were elevated up to above 1000/μL in these three patients, which decreased with ALIS discontinuation only. Of note, the specimen obtained by transbronchial lung cryobiopsy in one patient revealed a mild degree of lymphocyte and eosinophil infiltration. Rather, the findings of acute lung injury such as an edematous thickening of the alveolar walls, and an accumulation of foamy degenerative macrophages in the alveolar lumina was prominent. A pulmonary alveolar proteinosis reaction was also observed. HP-pattern pneumonitis due to ALIS may pathologically correspond to acute lung injury and a pulmonary alveolar proteinosis reaction despite increasing serum eosinophil counts., Competing Interests: Declaration of competing interest The authors have no conflicts of interest to declare., (Copyright © 2024. Published by Elsevier B.V.)
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- 2024
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6. Successful pembrolizumab treatment for microsatellite instability-high thymoma: A case report.
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Kaneko T, Sekine A, Komatsu S, Otoshi R, Haga S, Tagami Y, Kaneko T, and Ogura T
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- Humans, Treatment Outcome, Antineoplastic Combined Chemotherapy Protocols therapeutic use, Male, Carboplatin administration & dosage, Middle Aged, Antineoplastic Agents, Immunological therapeutic use, Antineoplastic Agents, Immunological administration & dosage, Female, Antibodies, Monoclonal, Humanized administration & dosage, Antibodies, Monoclonal, Humanized therapeutic use, Thymoma drug therapy, Thymoma genetics, Microsatellite Instability, Thymus Neoplasms drug therapy, Thymus Neoplasms genetics, Thymus Neoplasms pathology
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Microsatellite instability (MSI) is a valuable biomarker for immune checkpoint inhibitors. We report the first case of MSI-high thymoma successfully treated with pembrolizumab. This patient had pleural dissemination and was treated with two cytotoxic chemotherapy regimens including carboplatin and paclitaxel combination therapy and pemetrexed, which did not have the desired effect. Because MSI status was high by using the surgical specimen, pembrolizumab was administered as 3rd line chemotherapy. After three courses, the pleural lesions dramatically shrunk, which confirmed a partial response. Although MSI-high thymoma is rare, our results suggest the necessity to evaluate MSI status in patients with thymoma., Competing Interests: Declaration of competing interest The authors have no conflicts of interest., (Copyright © 2024 The Japanese Respiratory Society. Published by Elsevier B.V. All rights reserved.)
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- 2024
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7. Spontaneous regression of acute fibrinous organizing pneumonia induced by COVID-19 vaccination: A case report.
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Haga S, Otoshi R, Sekine A, Kaneko T, Yamada C, Baba T, Komatsu S, Sawazumi T, Takemura T, and Ogura T
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- Female, Humans, Adult, COVID-19 Vaccines adverse effects, Remission, Spontaneous, COVID-19, Pneumonia, Organizing Pneumonia
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A 42-year-old woman visited our hospital with complaints of fever, muscle pain, and dyspnea one week after receiving the coronavirus disease 2019 (COVID-19) vaccine. Chest high-resolution computed tomography showed a patchy consolidation and ground-glass attenuation in the both lungs, consistent with acute interstitial pneumonia. Transbronchial lung cryobiopsy revealed organizing pneumonia with marked intra-alveolar fibrin, and pathologically diagnosed as acute fibrinous organizing pneumonia (AFOP). Other causative diseases such as dermatomyositis was clinically ruled out, and COVID-19 vaccine-induced AFOP was diagnosed. Physician should check the history of COVID-19 vaccination when encountering a case of AFOP with an unknown cause., Competing Interests: Declaration of competing interest The authors have no conflicts of interest., (Copyright © 2024. Published by Elsevier B.V.)
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- 2024
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8. Treatment Strategies for Non-Small-Cell Lung Cancer with Comorbid Respiratory Disease; Interstitial Pneumonia, Chronic Obstructive Pulmonary Disease, and Tuberculosis.
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Otoshi R, Ikeda S, Kaneko T, Sagawa S, Yamada C, Kumagai K, Moriuchi A, Sekine A, Baba T, and Ogura T
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Non-small cell lung cancer (NSCLC) patients are often complicated by other respiratory diseases, including interstitial pneumonia (IP), chronic obstructive pulmonary disease (COPD), and pulmonary tuberculosis (TB), and the management of which can be problematic. NSCLC patients with IP sometimes develop fatal acute exacerbation induced by pharmacotherapy, and the establishment of a safe treatment strategy is desirable. For advanced NSCLC with IP, carboplatin plus nanoparticle albumin-bound paclitaxel is a relatively safe and effective first-line treatment option. Although the safety of immune checkpoint inhibitors (ICIs) for these populations remains controversial, ICIs have the potential to provide long-term survival. The severity of COPD is an important prognostic factor in NSCLC patients. Although COPD complications do not necessarily limit treatment options, it is important to select drugs with fewer side effects on the heart and blood vessels as well as the lungs. Active TB is complicated by 2-5% of NSCLC cases during their disease course. Since pharmacotherapy, especially ICIs, reportedly induces the development of TB, the possibility of developing TB should always be kept in mind during NSCLC treatment. To date, there is no coherent review article on NSCLC with these pulmonary complications. This review article summarizes the current evidence and discusses future prospects for treatment strategies for NSCLC patients complicated with IP, severe COPD, and TB.
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- 2024
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9. Concordance between transbronchial lung cryobiopsy and surgical lung biopsy in patients with idiopathic multicentric Castleman disease: A report of four cases.
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Otoshi R, Kitamura H, Baba T, Muraoka T, Sekine A, Takemura T, Okudela K, Sawazumi T, and Ogura T
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- Male, Female, Humans, Adult, Retrospective Studies, Bronchoscopy, Lung pathology, Biopsy, Immunoglobulin G, Castleman Disease diagnosis, Castleman Disease surgery, Castleman Disease pathology
- Abstract
Background: Idiopathic multicentric Castleman disease (iMCD) is a rare polyclonal lymphoproliferative disease often associated with pulmonary involvement. Recently, transbronchial lung cryobiopsy (TBLC) has been reported to be useful for the diagnosis of diffuse interstitial lung disease. However, there have been no reports of pathological assessment of TBLC for iMCD., Method: To clarify the efficacy of TBLC in the diagnosis of iMCD, we retrospectively reviewed four iMCD patients who had undergone both TBLC and surgical lung biopsy (SLB)., Results: The median age was 44 years; 2 males and 2 females. Two or three TBLC specimens were taken from each patient. All patients had no complications other than minimal bleeding. The size of the TBLC specimens was approximately 5-6 × 3-4 mm, and the alveolar region, and centrilobular and perilobular areas were adequately sampled. As with SLB, the extent of lung lesions and inflammatory cell infiltration could be sufficiently evaluated by TBLC. The presence of lymphoid follicles could also be assessed by TBLC; however, the germinal centers with lymphoid follicles were difficult to evaluate. The TBLC specimens could also be evaluated for immunostaining, especially IgG4 immunostaining, to rule out IgG4-related lung disease. Pulmonary pathological grading showed a high concordance rate between major pathological findings of TBLC and SLB. The pathologist's confidence level of TBLC for the diagnosis of iMCD was high in all cases., Conclusions: TBLC exhibits a high concordance rate with SLB in the pathological evaluation of iMCD, which may be useful for the diagnosis of iMCD., Competing Interests: Conflict of Interest The authors have no conflicts of interest., (Copyright © 2023. Published by Elsevier B.V.)
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- 2024
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10. Radiological and Pathological Features of Cyst Formation in Idiopathic Multicentric Castleman Disease.
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Otoshi R, Sekine A, Muraoka T, Iwasawa T, Takemura T, Matsushita S, Okudela K, Kitamura H, Baba T, and Ogura T
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- Male, Female, Humans, Adult, Retrospective Studies, Castleman Disease diagnostic imaging, Castleman Disease pathology, Lung Diseases pathology, Cysts pathology
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Introduction: Idiopathic multicentric Castleman disease (MCD) has been reported to form lung cysts at a relatively high rate. However, the radiological and pathological features of cystic formation in MCD are unclear., Methods: To clarify these questions, we retrospectively investigated the radiological and pathological findings of cysts in MCD patients. Eight consecutive patients who underwent surgical lung biopsies in our center from 2000 to 2019 were included., Results: The median age was 44.5 years, with three males and five females. On the initial computed tomography, cyst formation was found in seven patients (87.5%). All of the cysts were multiple, round, and thin walled, accompanying ground-glass attenuation (GGA) around cysts. In six patients (75%), cysts increased during their clinical courses, and the new cysts had emerged from GGA, although GGA was improved by treatment. In all four cases, whose pulmonary cysts could be pathologically evaluated, a marked plasma cell infiltration around the cyst wall, and loss of elastic fibers of the alveolar wall were observed., Conclusions: Pulmonary cysts emerged in the area of GGA pathologically consistent with plasma cell infiltration. Cysts in MCD may be formed by the loss of elastic fibers due to marked plasma cell infiltration and may be considered irreversible changes.
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- 2023
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11. Successful Treatment of Chylothorax and Chylopericardium by Radiotherapy in Lung Cancer.
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Shintani R, Sekine A, Murohashi K, Otoshi R, Kasuya T, Oda T, Baba T, Komatsu S, Ogura T, and Inoue Y
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- Humans, Male, Middle Aged, Vena Cava, Superior, Chylothorax diagnostic imaging, Chylothorax etiology, Lung Neoplasms complications, Lung Neoplasms radiotherapy, Lymphadenopathy complications, Pericardial Effusion diagnostic imaging, Pericardial Effusion etiology, Superior Vena Cava Syndrome etiology
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A 58-year-old man was diagnosed with stage IVB lung adenocarcinoma in the right upper lobe and underwent systemic chemotherapy. Seven months after the diagnosis, large left pleural and pericardial effusion was detected. The patient developed both chylothorax and chylopericardium following superior vena cava (SVC) obstruction with mediastinal lymphadenopathy caused by lung carcinoma. Since conservative treatment of the chyle leakage was ineffective, we administered radiotherapy to treat the SVC obstruction and mediastinal lymphadenopathy. After radiotherapy, the chylothorax and chylopericardium gradually resolved, and no further chyle leaks were identified on follow-up computed tomography. This case indicates that radiotherapy can be used to ameliorate lung cancer-related chylothorax and chylopericardium.
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- 2022
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12. Asbestos exposure and tuberculous pleurisy as developmental causes of progressive unilateral upper-lung field pulmonary fibrosis radiologically consistent with pleuroparenchymal fibroelastosis.
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Sekine A, Hagiwara E, Iwasawa T, Otoshi R, Erina T, Shintani R, Okabayashi H, Ikeda S, Oda T, Okuda R, Kitamura H, Baba T, Komatsu S, and Ogura T
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- Humans, Lung diagnostic imaging, Male, Pleura diagnostic imaging, Asbestos, Pulmonary Fibrosis, Tuberculosis, Pleural diagnostic imaging
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Background: Unilateral upper-lung field pulmonary fibrosis (upper-PF), which is radiologically consistent with pleuroparenchymal fibroelastosis, develops after thoracic surgery. In most patients with unilateral upper-PF, aberrant intra-/extra thoracic air commonly emerges and an autopsy shows chronic pleuritis, which indicates that pleural involvement is associated with upper-PF development. If so, there may be patients with unilateral upper-PF who have a history of pleural involvement, including tuberculous pleurisy (TP) or asbestos exposure (AE). This study aimed to examine this supposition., Methods: We examined the radiological reports of all consecutive patients from 2012 to 2018 to investigate whether there were patients having unilateral upper-PF and a history of TP or AE., Results: Eight patients were included in the study. Five patients had a history of TP, and the remaining three had that of AE. All patients were men and had respiratory symptoms, and seven patients presented with restrictive ventilatory impairment. The interval between TP or last AE and upper-PF development was long, with a median of over 20 years. The upper-PF lesion was commonly located in the right lung, and aberrant intrathoracic air was observed in five patients during their clinical course. Additionally, the upper-PF lesion transformed into a cystic lesion in six patients, which resulted in Aspergillus infection in two patients. The prognosis was poor, with a median overall survival of 38 months., Conclusions: Unilateral upper-PF developed even in patients with a history of pleural involvement. Our results indicate that pleural involvement plays an important role in the development of unilateral upper-PF., Competing Interests: Conflict of Interest All authors have no conflict of interest related to this study to declare., (Copyright © 2021 The Japanese Respiratory Society. Published by Elsevier B.V. All rights reserved.)
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- 2021
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13. Serum Krebs von den Lungen-6 levels are associated with mortality and severity in patients with coronavirus disease 2019.
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Yamaya T, Hagiwara E, Baba T, Kitayama T, Murohashi K, Higa K, Sato Y, Otoshi R, Tabata E, Shintani R, Okabayashi H, Ikeda S, Niwa T, Nakazawa A, Oda T, Okuda R, Sekine A, Kitamura H, Komatsu S, and Ogura T
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- Biomarkers, Humans, Mucin-1, Retrospective Studies, SARS-CoV-2, Severity of Illness Index, COVID-19
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Background: The serum Krebs von den Lungen-6 (KL-6) level is a predictive factor for acute respiratory distress syndrome (ARDS). The development of ARDS has been reported in patients with coronavirus disease 2019 (COVID-19). This study aimed to determine whether serum KL-6 levels are associated with mortality and severity in patients with COVID-19., Methods: Among 361 Japanese patients with COVID-19 who were hospitalized at Kanagawa Cardiovascular and Respiratory Center between February 2020 and December 2020, 356 patients with data on serum KL-6 levels were enrolled and their medical records were retrospectively analyzed., Results: A negative correlation was observed between KL-6 levels and the ratio of the arterial partial pressure of oxygen to the fraction of inspired oxygen on admission. The KL-6 levels on admission and the maximal KL-6 levels were higher in patients with severe disease (n = 60) than in those with nonsevere disease (n = 296). Furthermore, the maximal KL-6 levels were higher in nonsurvivors (n = 6) than in survivors (n = 350). In nonsurvivors, the KL-6 levels increased as the disease progressed. The optimal cutoff value of the maximal KL-6 level for discriminating between survivors and nonsurvivors was 684 U/mL, with a sensitivity of 83.3%, a specificity of 90.5%, and an area under the curve of 0.89., Conclusions: The serum KL-6 level was associated with disease severity. Patients with KL-6 levels ≥684 U/mL had a significantly poorer outcome than those with KL-6 levels <684 U/mL., Competing Interests: Conflict of Interest The authors declare no conflicts of interest, (Copyright © 2021. Published by Elsevier B.V.)
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- 2021
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14. Coronary artery disease and heart failure in patients with idiopathic pulmonary fibrosis.
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Kato S, Kitamura H, Hayakawa K, Fukui K, Tabata E, Otoshi R, Iwasawa T, Utsunomiya D, Kimura K, Tamura K, and Ogura T
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- Aged, Coronary Angiography, Humans, Male, Middle Aged, Prognosis, Retrospective Studies, Coronary Artery Disease diagnosis, Coronary Artery Disease epidemiology, Heart Failure diagnosis, Heart Failure epidemiology, Idiopathic Pulmonary Fibrosis complications, Idiopathic Pulmonary Fibrosis diagnosis, Idiopathic Pulmonary Fibrosis epidemiology, Lung Diseases, Interstitial
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The aim of this study was to investigate the prevalence and prognostic value of coronary artery disease (CAD) and heart failure (HF) in patients with idiopathic pulmonary fibrosis (IPF). Thirteen hundred and fifty-eight patients with interstitial lung disease [851 (62%) males, mean age: 68 ± 10 years] were retrospectively analyzed. CAD was defined as (1) the presence of a clinical diagnosis of angina pectoris, (2) clinical diagnosis of a myocardial infarction, and (3) coronary angiography showing ≥ 1 vessel with a stenosis of > 75%. The definition of HF was made according to the modified Framingham criteria. Compared to the non-IPF group (n = 790), the IPF group (n = 568) had a significantly higher prevalence of CAD (9.3% vs. 4.4%, p < 0.001) and HF (8.2% vs. 3.7%, p < 0.001). During a median follow-up of 1.6 years, 152 deaths were identified. The patients with HF had a significantly worse prognosis than those without HF both in the non-IPF group and IPF group (both p < 0.05). However, the prognosis did not significantly differ between the patients with CAD and those without CAD both in the non-IPF group and IPF group. The presence of HF was an independent predictor of death in the IPF [hazard ratio (HR) 3.67, 95% confidence interval (CI) 1.57-8.56, p = 0.0025] and non-IPF (HR 5.07, 95% CI 1.44-17.86, p = 0.011) patients. The prevalence of CAD and HF was significantly higher in IPF than non-IPF patients. In addition, the presence of HF was a significant prognostic factor for both IPF and non-IPF patients. These results indicated that the importance of HF as a comorbidity for patients with ILD.
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- 2021
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15. Clinical characteristics of Japanese patients with moderate to severe COVID-19.
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Otoshi R, Hagiwara E, Kitayama T, Yamaya T, Higa K, Murohashi K, Sato Y, Tabata E, Shintani R, Okabayashi H, Ikeda S, Niwa T, Nakazawa A, Oda T, Okuda R, Sekine A, Kitamura H, Baba T, Komatsu S, and Ogura T
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- Adult, Age Factors, Aged, Aged, 80 and over, Aspartate Aminotransferases blood, C-Reactive Protein analysis, Female, Humans, Japan epidemiology, L-Lactate Dehydrogenase blood, Lymphocyte Count, Male, Middle Aged, Retrospective Studies, SARS-CoV-2, Severity of Illness Index, COVID-19 diagnosis, COVID-19 pathology
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Introduction: Although several reports on the risk factors for severe disease of COVID-19 already exist, reports on effective early indicators are still limited, especially from Japan. This study was conducted to clarify the patient's characteristics whose disease progressed to severe status., Methods: The medical records of all consecutive 300 Japanese patients hospitalized at our institution between February and November 2020 were retrospectively reviewed. The clinical characteristics were evaluated to compare between mild (no oxygen needed), moderate (oxygen needs of 1-4 L/min), and severe diseases (oxygen needs of 5 L/min or more)., Results: The median age was 68 years old, with 123 (41.0%) males and 177 (59.0%) females. Of these, 199 patients (66.3%), 55 patients (18.3%), 46 patients (15.3%) patients were in the mild disease, moderate disease, severe disease groups, respectively. Patients with severe disease were more likely to be older, have more comorbidities, and tended to have higher body mass index. In laboratory data, lymphocyte count, levels of C-reactive protein (CRP), LDH, and AST on admission were significantly associated with the severity. In multivariate analysis, age and CRP were the independent risk factors for severe disease (OR = 1.050, 1.130, respectively). The optimal cut-off value for age was 74 years old and that for CRP was 3.15 mg/dL., Conclusions: Age and CRP were independently associated with disease severity of COVID-19 in multivariate analysis. Additionally, the numbers of underlying disease, lymphocyte count, and inflammatory markers such as LDH and D-dimer may also be related to disease severity., Competing Interests: Declaration of competing interest All of the authors report they have no conflict of interest to disclose., (Copyright © 2021 Japanese Society of Chemotherapy and The Japanese Association for Infectious Diseases. Published by Elsevier Ltd. All rights reserved.)
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- 2021
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16. Diverse Pathological Findings of Interstitial Lung Disease in a Patient with Dyskeratosis Congenita.
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Otoshi R, Baba T, Shintani R, Kitamura H, Yamaguchi Y, Hamanoue H, Mizuguchi T, Matsumoto N, Okudela K, Takemura T, and Ogura T
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- Adult, Biopsy, Cell Cycle Proteins genetics, Humans, Leukoplakia, Oral, Lung, Male, Nuclear Proteins, Dyskeratosis Congenita complications, Dyskeratosis Congenita diagnosis, Dyskeratosis Congenita genetics, Lung Diseases, Interstitial diagnosis, Lung Diseases, Interstitial genetics
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A 42-year-old man with a history of surgery for tongue cancer was referred to our hospital due to an abnormal chest shadow. High-resolution computed tomography showed lower lobe reticulation. A physical examination revealed nail dystrophy, oral leukoplakia, and reticulated hypopigmentation. Lung biopsy revealed subpleural and perilobular fibrosis, suggestive of usual interstitial pneumonia. However, multiple pathological findings, including homogenous fibrosis and cell infiltration in the centrilobular region, which were compatible with nonspecific interstitial pneumonia, and bronchiolitis were also seen. Genetic testing showed a hemizygous missense mutation in the DKC1 gene, and the patient was diagnosed with dyskeratosis congenita. Although anti-fibrotic therapy was initiated, the patient's respiratory function has continued to decrease.
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- 2021
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17. Outcome of early-stage combination treatment with favipiravir and methylprednisolone for severe COVID-19 pneumonia: A report of 11 cases.
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Murohashi K, Hagiwara E, Kitayama T, Yamaya T, Higa K, Sato Y, Otoshi R, Shintani R, Okabayashi H, Ikeda S, Niwa T, Nakazawa A, Oda T, Okuda R, Sekine A, Kitamura H, Baba T, Komatsu S, Iwasawa T, Kaneko T, and Ogura T
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- Amides, Antiviral Agents therapeutic use, Humans, Pyrazines, SARS-CoV-2, Treatment Outcome, COVID-19, Methylprednisolone
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Although the use of corticosteroids is not recommended in the World Health Organization statement for the treatment of coronavirus disease 2019 (COVID-19), steroid therapy may be indicated for critical cases in specific situations. Here, we report the successful treatment of 11 cases of severe COVID-19 pneumonia with favipiravir and methylprednisolone. All cases were severe and patients required oxygen administration or had a blood oxygen saturation ≤93% on room air. All were treated with favipiravir and methylprednisolone, and 10 of 11 patients responded well and required no further oxygen supplementation or ventilator management. This study shows the importance of the early-stage use of a combination of favipiravir and methylprednisolone in severe cases to achieve a favorable clinical outcome., Competing Interests: Conflict of Interest None of the authors have any real or perceived conflicts of interest to declare regarding the subject of this manuscript., (Copyright © 2020 The Japanese Respiratory Society. Published by Elsevier B.V. All rights reserved.)
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- 2020
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18. Relationship of flow-volume curve pattern on pulmonary function test with clinical and radiological features in idiopathic pulmonary fibrosis.
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Nakagawa H, Otoshi R, Isomoto K, Katano T, Baba T, Komatsu S, Hagiwara E, Nakano Y, Kuwahira I, and Ogura T
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- Aged, Female, Humans, Idiopathic Pulmonary Fibrosis mortality, Male, Middle Aged, Retrospective Studies, Survival Analysis, Idiopathic Pulmonary Fibrosis pathology, Idiopathic Pulmonary Fibrosis physiopathology, Lung pathology, Lung physiopathology, Respiratory Function Tests, Tomography, X-Ray Computed
- Abstract
Background: The flow-volume (FV) curve pattern in the pulmonary function test (PFT) for obstructive lung diseases is widely recognized. However, there are few reports on FV curve pattern in idiopathic pulmonary fibrosis (IPF). In this study, we investigated the relationship between FV curve pattern and clinical or radiological features in IPF., Methods: The FV curves on PFTs and chest high-resolution computed tomography (HRCT) images of 130 patients with IPF were retrospectively evaluated. The FV curves were divided into four groups based on the presence or absence of the convex and concave patterns: convex/concave, non-convex/concave, convex/non-concave, and non-convex/non-concave. Using a computer-aided system, CT honeycombing area (%HA) and subtracted low attenuation area (%sLAA) were quantitatively measured. To assess the distribution of CT findings, the lung area was divided into upper, lower, central, and peripheral areas. The relationships of FV curve patterns with patient characteristics, spirometry results, and quantitative CT findings were evaluated., Results: The patients with convex pattern was identified in 93 (71.5%) and concave pattern in 72 (55.4%). Among the four groups, patients with the convex/non-concave pattern had significantly lower forced vital capacity (FVC) and higher %HA of the upper/peripheral lung area (p = 0.018, and p = 0.005, respectively). The convex/non-concave pattern was a significant predictor of mortality for IPF (hazard ratio, 2.19; p = 0.032)., Conclusions: Patients with convex/non-concave pattern in FV curve have lower FVC and poorer prognosis with distinct distribution of fibrosis. Hence, FV curve pattern might be a useful predictor of mortality in IPF.
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- 2020
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19. Small-cell lung carcinoma transformation of lung adenocarcinoma diagnosed by pericardial effusion: A case report.
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Otoshi R, Sekine A, Okudela K, Asaoka M, Sato Y, Ikeda S, Baba T, Komatsu S, Hagiwara E, and Ogura T
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The present report describes a case of a 68-year-old male patient with epidermal growth factor receptor (EGFR)-mutant non-small cell lung carcinoma (NSCLC). After cytotoxic chemotherapy of three regimens following 22 months of treatment with EGFR-tyrosine kinase inhibitors (EGFR-TKIs), including osimertinib, the patient underwent S-1 treatment. Despite a decrease in carcinoembryonic antigen 1 month after initiating S-1 treatment, the patient developed cardiac tamponade. The evaluation of pericardial effusion confirmed small-cell lung carcinoma (SCLC) transformation. Subsequently, a combination therapy of carboplatin and etoposide was administered, which led to a marked improvement in imaging. In patients with NSCLC who develop pericardial effusion after long-term EGFR-TKI therapy, including osimertinib treatment, it is important to investigate whether SCLC transformation occurs or not as a treatable entity., (Copyright: © Otoshi et al.)
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- 2020
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20. Miliary lung metastases from ROS1-rearranged lung adenocarcinoma: A case report.
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Otoshi R, Sekine A, Okudela K, Katano T, Asaoka M, Ikeda S, Baba T, Komatsu S, Hagiwara E, and Takashi O
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Miliary lung metastases are a rare form of metastasis of non-small-cell lung carcinoma. Miliary lung metastases commonly develop in lung adenocarcinoma with epidermal growth factor receptor mutation. In the present study, we present a case of miliary lung metastases from lung adenocarcinoma with ROS1 rearrangement. The patient, who had a history of surgery for stage IIIA lung adenocarcinoma, presented to our hospital with cough, dyspnea, and severe hypoxia. Chest computed tomography showed numerous tiny, randomly distributed nodules throughout both lungs. No metastases were observed in other organs. Molecular profiling of the surgical specimens was positive for ROS1 rearrangement. The results suggest that chest physicians should be aware that miliary lung metastases can develop in patients with lung adenocarcinoma with ROS1 rearrangement., (Copyright © 2020, Spandidos Publications.)
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- 2020
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21. Effectiveness and Safety of Bronchial Thermoplasty in the Treatment of Severe Asthma with Smoking History: A Single-Center Experience.
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Otoshi R, Baba T, Aiko N, Tabata E, Sadoyama S, Nakagawa H, Sekine A, Komatsu S, Hagiwara E, and Ogura T
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- Adult, Female, Humans, Male, Middle Aged, Retrospective Studies, Asthma etiology, Asthma therapy, Bronchial Thermoplasty methods, Smoking adverse effects
- Abstract
Introduction: Bronchial thermoplasty (BT) improves asthma-related quality of life and decreases the number of asthma exacerbations. However, the effectiveness of BT in the treatment of severe asthma with smoking history is unclear because previous studies have excluded patients with smoking history of more than 10 pack-years., Objective: The aim of the study was to clarify the effectiveness and safety of BT for severe asthma with smoking history., Methods: We retrospectively reviewed patients who received BT and compared its effectiveness and safety with and without smoking history., Results: Seven patients were assigned to the smoking group and 9 to the nonsmoking group. Before BT, despite Global Initiative for Asthma step 4 or 5 treatment including oral corticosteroids (OCS) or monoclonal antibody drugs, most patients in both groups had asthma-related symptoms every day (85.7 vs. 77.8%; p = 0.475) and frequent asthma exacerbations. After BT, in the smoking group, 3 patients could discontinue or reduce OCS and all 3 patients treated with monoclonal antibody drugs could discontinue them. In the smoking group, 6 patients (85.7%) experienced a reduction in the rate of symptoms, of which 3 patients (42.9%) had a disappearance of symptoms, similar to the nonsmoking group. BT was effective in 5 patients (83.3%) in the smoking group and 6 patients (75.0%) in the nonsmoking group. There were no severe complications., Conclusions: BT was found to be effective and safe for treatment of severe asthma with smoking history. Our results suggest that BT may be a therapeutic option for asthma-chronic obstructive pulmonary disease overlap., (© 2020 S. Karger AG, Basel.)
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- 2020
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22. Effectiveness of mepolizumab for eosinophilic pneumonia following bronchial thermoplasty.
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Otoshi R, Baba T, Komatsu S, Asaoka M, Hagiwara E, and Ogura T
- Abstract
A 57-year-old woman with poorly controlled diabetes was admitted to our hospital for additional treatment of severe asthma. Although bronchial thermoplasty was performed in the both upper lobes, cough and dyspnoea gradually appeared 2 weeks later. High-resolution computed tomography revealed thickness of intralobular septa and a diffuse ground-glass attenuation in the lung fields. Laboratory examination revealed elevated levels of serum eosinophils and total immunoglobulin E. Bronchoalveolar lavage fluid showed a remarkable increase of eosinophils as high as 48.5%, then eosinophilic pneumonia was diagnosed. Although treatment with steroids resulted in an improvement of eosinophilic pneumonia, the treatment was discontinued after 4 days because it worsened her diabetic condition. Since eosinophilic pneumonia recurred after discontinuing steroid, mepolizumab was administered, which subsequently improved her disease condition. Clinicians should be aware that bronchial thermoplasty can lead to eosinophilic pneumonia and mepolizumab might be an effective treatment in this setting., (© 2019 The Authors. Respirology Case Reports published by John Wiley & Sons Australia, Ltd on behalf of The Asian Pacific Society of Respirology.)
- Published
- 2019
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23. Pemetrexed-induced Interstitial Lung Disease Mimicking Hypersensitivity Pneumonia: A Pathologically Proven Case.
- Author
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Otoshi R, Sekine A, Hagiwara E, Okudela K, Katano T, Aiko N, Matama G, Isomoto K, Ikeda S, Baba T, Komatsu S, and Ogura T
- Subjects
- Biopsy, Diagnosis, Differential, Dyspnea etiology, Female, Humans, Lung Diseases, Interstitial complications, Lung Diseases, Interstitial diagnosis, Lung Diseases, Interstitial pathology, Middle Aged, Tomography, X-Ray Computed, Adenocarcinoma of Lung drug therapy, Alveolitis, Extrinsic Allergic diagnosis, Antineoplastic Agents adverse effects, Lung Diseases, Interstitial chemically induced, Lung Neoplasms drug therapy, Pemetrexed adverse effects
- Abstract
We herein report a 45-year-old woman with lung adenocarcinoma stage IV (cT4N3M1a). She was treated with pemetrexed (PEM) monotherapy following four cycles of first-line treatment with carboplatin, paclitaxel, and veliparib. After three cycles of PEM treatment, she presented with dyspnea, and chest computed tomography showed diffuse ground-glass attenuation (GGA), suggesting hypersensitivity pneumonia (HP). Bronchoalveolar lavage revealed a marked increase in lymphocytes (90.5%), and a transbronchial lung biopsy confirmed lymphocytic alveolitis with granuloma. Because her symptoms and diffuse GGA were spontaneously resolved with PEM discontinuation alone, PEM-induced interstitial lung disease was diagnosed. Chest physicians should be aware that PEM can induce HP-type interstitial lung disease.
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- 2019
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24. Evaluation of changes in the serum levels of Krebs von den Lungen-6 and surfactant protein-D over time as important biomarkers in idiopathic fibrotic nonspecific interstitial pneumonia.
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Yamakawa H, Hagiwara E, Ikeda S, Iwasawa T, Otoshi R, Tabata E, Okuda R, Sekine A, Baba T, Iso S, Okudela K, Takemura T, and Ogura T
- Subjects
- Aged, Biomarkers blood, Disease Progression, Female, Humans, Male, Middle Aged, Predictive Value of Tests, Retrospective Studies, Time Factors, Idiopathic Interstitial Pneumonias diagnosis, Idiopathic Pulmonary Fibrosis diagnosis, Mucin-1 blood, Pulmonary Surfactant-Associated Protein D blood
- Abstract
Background: Some cases of idiopathic fibrotic nonspecific interstitial pneumonia (f-NSIP) show a progressive course that is similar to that of idiopathic pulmonary fibrosis. However, it is difficult to predict poor patient outcomes. This study aimed to evaluate whether serial changes in serum levels of Krebs von den Lungen-6 (KL-6) and surfactant protein-D (SP-D) can predict disease progression., Methods: We retrospectively analyzed the medical records of 75 patients with idiopathic f-NSIP. Disease behavior was categorized into two groups depending on long-term change of pulmonary function: progressive type (≥5%/year relative decline in the slope of forced vital capacity [FVC] and/or ≥7.5%/year relative decline in the slope of %diffusing capacity of the lung for carbon monoxide [%D
LCO ]) and stable type. Levels of KL-6 and SP-D and results of pulmonary function tests, which were performed parallelly, were reviewed and analyzed using a linear mixed-effects model., Results: The study subjects comprised 62 patients with stable type and 13 patients with progressive type disease behavior. Among these subjects, 50 patients fulfilled the diagnostic criteria of interstitial pneumonia with autoimmune features (IPAF). Serum levels of both KL-6 and SP-D at baseline showed a negative correlation with %DLCO , but not with FVC, and these biomarkers were not related to disease progression. Persistently high levels of KL-6 and SP-D correlated with progressive type disease behavior in idiopathic (non-IPAF) f-NSIP., Conclusions: Changes in serum KL-6 and SP-D levels over time may provide useful predictive information on disease behavior during treatment in patients with idiopathic f-NSIP and especially in those with non-IPAF f-NSIP., (Copyright © 2019 The Japanese Respiratory Society. Published by Elsevier B.V. All rights reserved.)- Published
- 2019
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25. Clinical characteristics and early outcomes of patients newly diagnosed with pulmonary Mycobacterium avium complex disease.
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Hagiwara E, Katano T, Isomoto K, Otoshi R, Yamakawa H, Okuda R, Sekine A, Baba T, Komatsu S, and Ogura T
- Subjects
- Adult, Age Factors, Aged, Aged, 80 and over, Antibiotics, Antitubercular administration & dosage, Antibodies, Bacterial blood, Biomarkers blood, Clarithromycin administration & dosage, Female, Humans, Immunoglobulin A blood, Incidental Findings, Male, Middle Aged, Mycobacterium avium Complex immunology, Mycobacterium avium-intracellulare Infection diagnosis, Mycobacterium avium-intracellulare Infection epidemiology, Mycobacterium avium-intracellulare Infection microbiology, Radiography, Thoracic, Retrospective Studies, Treatment Outcome, Tuberculosis, Pulmonary diagnosis, Tuberculosis, Pulmonary epidemiology, Tuberculosis, Pulmonary microbiology, Young Adult, Mycobacterium avium-intracellulare Infection drug therapy, Tuberculosis, Pulmonary drug therapy
- Abstract
Background: The incidence of asymptomatic pulmonary Mycobacterium avium complex (MAC) disease appears to be increasing. This study aimed to determine the clinical characteristics and examine early outcomes of patients newly diagnosed with MAC disease., Methods: We retrospectively reviewed the medical records of all 184 patients newly diagnosed with MAC disease between April 2013 and March 2015 at our hospital. Culture conversion, defined as at least two consecutive negative cultures, was used as the early outcome measure., Results: Of 184 patients, 45 were male and 139 were female, with a mean age of 70 years. Abnormal chest shadow found during an annual health check-up (58 patients) or incidentally during visits for other diseases (72 patients), was the major reason for referral to hospital, typically with no symptoms. Anti-MAC IgA antibody was positive in 64.5% of patients, and the positive rate was associated with the extent of lesions. Clarithromycin-based multi-drug chemotherapy was initiated in 111 patients. Culture conversion was achieved in 61 of 82 (74.4%) patients who were able to continue multi-drug chemotherapy. Patients who achieved culture conversion were more likely to be younger, female, and have a lower smear grade and nodular-bronchiectatic type. Multivariate logistic regression analysis identified patient age and smear grade as predictive variables., Conclusions: Abnormal chest shadow found during health check-up was the major reason for hospital visits, and most were asymptomatic. Culture conversion was achieved in three-fourths of patients treated, and was associated with age and smear grade, supporting early intervention at a younger age., (Copyright © 2018 The Japanese Respiratory Society. Published by Elsevier B.V. All rights reserved.)
- Published
- 2019
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26. Anti-Ku antibody-positive desquamative interstitial pneumonia.
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Otoshi R, Yamakawa H, Takemura T, Katano T, Aiko N, Matama G, Isomoto K, Baba T, Hagiwara E, and Ogura T
- Abstract
A 66-year-old man, an ex-smoker, was referred to our hospital for slightly progressive respiratory symptoms of cough and dyspnea on exertion and chest abnormal shadow. Chest high-resolution computed tomography showed wide-ranging ground-glass attenuation and reticulation with lower lobe predominance. Bronchoalveolar lavage (BAL) fluid revealed a marked increase in lymphocytes (53.0%), and a surgical lung biopsy revealed a pattern of desquamative interstitial pneumonia (DIP) with hyperplasia of the lymphoid follicles. His serum was positive for anti-Ku and anti-SS-A antibodies, and he had signs (such as Raynaud's phenomenon, joint pain, and mechanic's hand) suspicious of connective tissue disease (CTD) although a definitive diagnosis of CTD had not been established. On the basis of the findings in our patient obtained from the serologic domain, BAL, and pathological examination, clinicians should consider the important correlation of DIP with CTD as well as with smoking.
- Published
- 2018
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27. The Spontaneous Regression of Grade 3 Methotrexate-related Lymphomatoid Granulomatosis: A Case Report and Literature Review.
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Aiko N, Sekine A, Umeda S, Katano T, Matama G, Isomoto K, Otoshi R, and Ogura T
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- Aged, Humans, Lymphomatoid Granulomatosis diagnostic imaging, Lymphomatoid Granulomatosis pathology, Male, Multiple Pulmonary Nodules diagnostic imaging, Multiple Pulmonary Nodules pathology, Neoplasm Grading, Radiography, Remission, Spontaneous, Withholding Treatment, Antimetabolites, Antineoplastic therapeutic use, Lymphomatoid Granulomatosis drug therapy, Methotrexate therapeutic use, Multiple Pulmonary Nodules drug therapy
- Abstract
Lymphomatoid granulomatosis (LYG) is a rare lung disorder diagnosed by radiological imaging of multiple pulmonary nodules and occasionally induced by methotrexate (MTX) use. To date, the treatment of LYG has not been standardized. We herein report the case of a patient with grade 3 MTX-related LYG who presented a bulky lung mass. Importantly, the disease condition only improved after the discontinuation of MTX and remained stable for more than 1 year. Chest physicians should be aware that LYG can develop as a single lung mass and spontaneously regress, even without aggressive chemotherapy, following the cessation of MTX.
- Published
- 2018
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28. Interstitial lung disease associated with anti-citrullinated peptide/protein antibody-positive anti-synthetase syndrome.
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Yamakawa H, Hagiwara E, Iwasawa T, Otoshi R, Tabata E, Ikeda S, Okuda R, Baba T, Iso S, Okudela K, Takemura T, Sato S, and Ogura T
- Abstract
Little has been reported on the characteristics of interstitial lung disease (ILD) associated with anti-citrullinated peptide/protein antibody (ACPA)-positive anti-synthetase syndrome (ASS). We sought to investigate the clinical, radiologic, and pathologic features of patients with ILD associated with ACPA-positive ASS. Medical records of seven ILD patients with positive results of both ACPA and anti-aminoacyl-tRNA synthetase antibody were retrospectively reviewed. Five patients had clinical symptoms associated with ASS other than ILD. On high-resolution computed tomography (HRCT) analysis, a nonspecific interstitial pneumonia (NSIP) pattern was shown in 3 patients and NSIP with organizing pneumonia (OP) overlap in 2 patients. Coronal slices of these 5 patients showed lower lung disease predominance with traction caudally on major fissures due to lower lobe volume loss. These were features that could commonly be observed in ASS-associated ILD. Pathological findings available for 3 patients showed NSIP. The characteristics of ILD associated with ACPA-positive ASS appear to be similar to those of ILD associated with ASS, but not to rheumatoid arthritis (RA) or ACPA, especially in terms of the radiological findings., Competing Interests: Conflicts of Interest: All work was performed at the Kanagawa Cardiovascular and Respiratory Center. The authors have no conflicts of interest to declare.
- Published
- 2018
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29. Predictive Factors for the Long-Term Deterioration of Pulmonary Function in Interstitial Lung Disease Associated with Anti-Aminoacyl-tRNA Synthetase Antibodies.
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Yamakawa H, Hagiwara E, Kitamura H, Iwasawa T, Otoshi R, Aiko N, Katano T, Shintani R, Ikeda S, Okuda R, Sekine A, Baba T, Iso S, Kuwano K, Sato S, and Ogura T
- Subjects
- Aged, Anti-Inflammatory Agents therapeutic use, Disease Progression, Female, Humans, Lung Diseases, Interstitial diagnostic imaging, Lung Diseases, Interstitial drug therapy, Lung Diseases, Interstitial immunology, Male, Middle Aged, Radiography, Thoracic, Respiratory Function Tests, Retrospective Studies, Tomography, X-Ray Computed, Amino Acyl-tRNA Synthetases immunology, Lung physiopathology, Lung Diseases, Interstitial physiopathology
- Abstract
Background: Little has been reported on long-term pulmonary function trends among patients with interstitial lung disease associated with anti-aminoacyl-tRNA synthetase antibodies (ARS-ILD)., Objectives: To clarify the factors predictive of progression in ARS-ILD based on patients' initial clinical and radiological features., Methods: The clinical courses of 88 patients with > 1 year of follow-up data on pulmonary function tests (PFTs) were retrospectively analyzed. Disease behavior was categorized into three groups: (1) improved or (2) worsened (defined as increases or decreases, respectively, of > 10% in forced vital capacity and > 15% in %diffusing capacity of lung carbon monoxide) or (3) stable based on PFT changes compared between 1-year results as the initial data and results at 3 years to assess the long-term course., Results: In the initial course of 75 patients with ARS-ILD who received anti-inflammatory therapy within 6 months after diagnosis, 48 patients (64.0%) improved and 6 patients (8.0%) worsened. The radiological patterns in the patients with ARS-ILD included nonspecific interstitial pneumonia (NSIP) in 46.7% and NSIP with organizing pneumonia overlap in 52.0% of the cases. One-third of the initially improved patients who worsened over the long-term course were assigned to the unstable group. By multivariate logistic analysis, middle lobe traction bronchiectasis was a significant predictive factor for the patients in the unstable group., Conclusions: Most patients with ARS-ILD receiving anti-inflammatory therapy had improved or remained stable in the first year. However, over the long-term course, some patients worsened despite their initial improvement. Even though the extent of the disease is limited, middle lobe traction bronchiectasis in ARS-ILD may be a useful predictor of poor long-term disease behavior., (© 2018 S. Karger AG, Basel.)
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- 2018
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30. A case of relapsed lung abscess caused by Eubacterium brachy infection following an initial diagnosis of pulmonary actinomycosis.
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Yamakawa H, Hagiwara E, Hayashi M, Katano T, Isomoto K, Otoshi R, Shintani R, Ikeda S, Tanaka K, and Ogura T
- Abstract
We report a rare case of lung abscess due to Eubacterium brachy . In this case, an analysis of the aspirate from frank pus revealed Gram-positive coccobacilli. We initially strongly suspected lung abscess associated with actinomycosis because of the chronic/recurrent clinical course and radio-pathological findings such as a granuloma lesion. Although a biochemical analysis revealed Actinomyces sp., 16S rRNA gene sequencing and a phylogenetic tree analysis of the isolated strain confirmed the presence of E. brachy . Some cases previously diagnosed as actinomycosis might be correctly diagnosed as E. brachy infection. Clinicians should be aware that additional studies using 16S rRNA gene sequencing are needed to clarify whether pulmonary infection associated with E. brachy is a similar entity to that of chronic granulomatous infection disease in pulmonary actinomycosis.
- Published
- 2017
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