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13 results on '"Otonari, Takatoshi"'

1. Ezetimibe Lipid-Lowering Trial on Prevention of Atherosclerotic Cardiovascular Disease in 75 or Older (EWTOPIA 75): A Randomized, Controlled Trial

Author

Ouchi, Yasuyoshi, Sasaki, Jun, Arai, Hidenori, Yokote, Koutaro, Harada, Kazumasa, Katayama, Yasuo, Urabe, Takao, Uchida, Yasufumi, Hayashi, Masaru, Yokota, Naoto, Nishida, Hirokazu, Otonari, Takatoshi, Arai, Tadashi, Sakuma, Ichiro, Sakabe, Kazuo, Yamamoto, Masayasu, Kobayashi, Takashi, Oikawa, Shinichi, Yamashita, Shizuya, Rakugi, Hiromi, Imai, Takumi, Tanaka, Shiro, Ohashi, Yasuo, Kuwabara, Masanari, and Ito, Hideki

Published
2019
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2. A 52-Week, Randomized, Open-Label, Parallel-Group Comparison of the Tolerability and Effects of Pitavastatin and Atorvastatin on High-Density Lipoprotein Cholesterol Levels and Glucose Metabolism in Japanese Patients with Elevated Levels of Low-Density Lipoprotein Cholesterol and Glucose Intolerance

Author

Sasaki, Jun, Ikeda, Yoshihiko, Kuribayashi, Tadanobu, Kajiwara, Keizou, Biro, Sadatoshi, Yamamoto, Kyosuke, Ageta, Masato, Kobori, Syozou, Saikawa, Tetsunori, Otonari, Takatoshi, and Kono, Suminori

Published
2008
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3. Comparison of three α-glucosidase inhibitors for glycemic control and bodyweight reduction in Japanese patients with obese type 2 diabetes

Author

Sugihara, Hitoshi, primary, Nagao, Mototsugu, additional, Harada, Taro, additional, Nakajima, Yasushi, additional, Tanimura-Inagaki, Kyoko, additional, Okajima, Fumitaka, additional, Tamura, Hideki, additional, Inazawa, Takeshi, additional, Otonari, Takatoshi, additional, Kawakami, Masanobu, additional, and Oikawa, Shinichi, additional

Published
2013
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5. 722 IMPACT OF ANTIHYPERTENSIVE MEDICATION ADHERENCE ON BLOOD PRESSURE CONTROL IN HYPERTENSION

Author

Matsumura, Kiyoshi, primary, Arima, Hisatomi, additional, Tominaga, Mitsuhiro, additional, Ohtsubo, Toshio, additional, Sasaguri, Toshiyuki, additional, Fujii, Koji, additional, Fukuhara, Masayo, additional, Uezono, Keiko, additional, Morinaga, Yuki, additional, Ohta, Yuko, additional, Otonari, Takatoshi, additional, Kawasaki, Junya, additional, Kato, Isao, additional, and Tsuchihashi, Takuya, additional

Published
2012
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6. 859 DOES A COMBINATION PILL OF ANTIHYPERTENSIVE DRUGS IMPROVE MEDICATION ADHERENCE IN JAPANESE?

Author

Matsumura, Kiyoshi, primary, Arima, Hisatomi, additional, Tominaga, Mitsuhiro, additional, Ohtsubo, Toshio, additional, Sasaguri, Toshiyuki, additional, Fujii, Koji, additional, Fukuhara, Masayo, additional, Uezono, Keiko, additional, Morinaga, Yuki, additional, Ohta, Yuko, additional, Otonari, Takatoshi, additional, Kawasaki, Junya, additional, Kato, Isao, additional, and Tsuchihashi, Takuya, additional

Published
2012
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7. Does a Combination Pill of Antihypertensive Drugs Improve Medication Adherence in Japanese?

Author

Matsumura, Kiyoshi, primary, Arima, Hisatomi, additional, Tominaga, Mitsuhiro, additional, Ohtsubo, Toshio, additional, Sasaguri, Toshiyuki, additional, Fujii, Koji, additional, Fukuhara, Masayo, additional, Uezono, Keiko, additional, Morinaga, Yuki, additional, Ohta, Yuko, additional, Otonari, Takatoshi, additional, Kawasaki, Junya, additional, Kato, Isao, additional, and Tsuchihashi, Takuya, additional

Published
2012
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9. Effect of losartan on serum uric acid in hypertension treated with a diuretic: the COMFORT study.

Author

Matsumura, Kiyoshi, Arima, Hisatomi, Tominaga, Mitsuhiro, Ohtsubo, Toshio, Sasaguri, Toshiyuki, Fujii, Koji, Fukuhara, Masayo, Uezono, Keiko, Morinaga, Yuki, Ohta, Yuko, Otonari, Takatoshi, Kawasaki, Junya, Kato, Isao, and Tsuchihashi, Takuya

Subjects
LOSARTAN, SERUM, URIC acid, HYPERTENSION, THERAPEUTICS, DIURETICS, ANGIOTENSIN II, DRUG efficacy, THIAZIDES
Abstract

It has been shown that losartan, an angiotensin II receptor blocker (ARB), reduces serum uric acid levels. However, the effects of losartan on serum uric acid levels in the patients treated with a thiazide diuretic have not been fully elucidated. We have investigated the effects of losartan compared with other ARBs on blood variables and blood pressure control in hypertensive patients treated with a thiazide diuretic using data from the COMFORT study. The present analysis included a total of 118 hypertensive subjects on combination treatment with ARBs except for losartan and a diuretic who were randomly assigned to a daily regimen of a combination pill (losartan 50 mg/hydrochlorothiazide 12.5 mg) or to continuation of two pills, an ARB except for losartan and a diuretic. Blood pressures were evaluated at 1, 3, and 6 months after randomization and changes in blood variables including serum uric acid were evaluated during 6 months treatment period. Mean follow-up blood pressure levels were not different between the combination pill (losartan treatment) group and the control (ARBs except for losartan) group. On the other hand, serum uric acid significantly decreased in the combination pill group compared with the control group (−0.44 versus + 0.10 mg/dl; p = 0.01), although hematocrit, serum creatinine, sodium and potassium were not different between the groups. These results suggest that the treatment regimen switched from a combination therapy of ARBs except for losartan and a diuretic to a combination pill (losartan/ hydrochlorothiazide) decreases serum uric acid without affecting blood pressure control. [ABSTRACT FROM AUTHOR]

Published
2015
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10. Comparison of three α-glucosidase inhibitors for glycemic control and bodyweight reduction in Japanese patients with obese type 2 diabetes.

Author

Sugihara, Hitoshi, Nagao, Mototsugu, Harada, Taro, Nakajima, Yasushi, Tanimura‐Inagaki, Kyoko, Okajima, Fumitaka, Tamura, Hideki, Inazawa, Takeshi, Otonari, Takatoshi, Kawakami, Masanobu, and Oikawa, Shinichi

Subjects
CARBOHYDRATE intolerance, GLUCOSIDASE inhibitors, GLYCEMIC index, BODY weight, DIABETES
Abstract

Aims/Introduction α-Glucosidase inhibitors (α GIs) are widely used for the primary treatment of type 2 diabetes. We compared the clinical effects of three α GIs (miglitol, acarbose and voglibose) in patients with obese type 2 diabetes. Materials and Methods Japanese patients ( n = 81) with obese type 2 diabetes (body mass index [ BMI] ≥25 kg/m2) were enrolled in this multicenter, open-label study. The participants were randomized into the miglitol ( n = 18), acarbose ( n = 22), voglibose ( n = 19) or control ( n = 22) groups. Glycemic control (fasting blood glucose and glycated hemoglobin [HbA1c]), bodyweight, BMI, serum insulin, serum lipids (low-density lipoprotein and high-density lipoprotein cholesterol, and triacylglycerols) and adipocytokines (leptin and adiponectin) were evaluated every 4 weeks for 12 weeks. Results In the miglitol group, Hb A1c was improved significantly from the baseline at all points. The changes in Hb A1c at 8 and 12 weeks from baseline were greater in the miglitol group than the control group. The voglibose group showed significant improvements in Hb A1c at 12 weeks. Bodyweight and BMI were decreased significantly in the miglitol group. In addition, significant correlations were observed between the decrements in Hb A1c and bodyweights over 12 weeks in the miglitol ( r = 0.759, P < 0.001) and voglibose groups ( r = 0.667, P = 0.002). Serum lipid and adipocytokine levels were not altered in any groups. Conclusions α GIs, especially miglitol, can effectively control blood glucose and bodyweight in obese type 2 diabetes. This study was registered with UMIN (no. UMIN000006465). [ABSTRACT FROM AUTHOR]

Published
2014
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12. A Double-Blind Comparative Study of Aspoxicillin and Piperacillin in the Treatment of Respiratory Tract Infections

Author

SAITO, Akira, primary, ISHIKAWA, Kiyofumi, additional, NAKAYAMA, Ichiro, additional, TOMIZAWA, Masumi, additional, ABE, Morikuni, additional, SHIBAKI, Hidetoshi, additional, CHIMOTO, Takehisa, additional, TANAKA, Masahiro, additional, ITO, Choei, additional, TAKEUCHI, Keisuke, additional, KOJIMA, Aiji, additional, SHIMOYAMA, Kazuo, additional, TAKASHIRO, Yoshinobu, additional, OHNISHI, Shinji, additional, SHINOHARA, Masahide, additional, UJIIE, Akira, additional, YAJIMA, Osamu, additional, NAGAHAMA, Fumio, additional, NISHIHARA, Hisaji, additional, SASAKI, Yuichi, additional, NAKABAYASHI, Takehito, additional, KOROKU, Tetsuji, additional, KURODA, Rensuke, additional, SHIMOMURA, Jutaro, additional, OSHIMA, Shin-ichi, additional, ONODERA, Sokichi, additional, SASAKI, Nobuhiro, additional, SUZUKI, Akira, additional, NATSUIZAKA, Tohru, additional, HIRAGA, Yohmei, additional, KIKUCHI, Kohki, additional, YAMAMOTO, Asako, additional, KIKUIRI, Tsuyoshi, additional, MURAKAMI, Tadashi, additional, TSUCHIHASHI, Kazufumi, additional, TAKEBE, Kazuo, additional, OKAMOTO, Katsuhiro, additional, TOSHIDA, Shuichiro, additional, OHMI, Tadanao, additional, TAKAHASHI, Shuichi, additional, KARIYA, Katsutoshi, additional, ONUMA, Tomio, additional, OCHIAI, Shigeru, additional, KUMASAKA, Yoshihiro, additional, YANAGIYA, Shigetoshi, additional, UEHARA, Osamu, additional, WATABIKI, Yasukimi, additional, MASAKI, Naoyoshi, additional, TAMURA, Toyoichi, additional, TAMAZAWA, Naoki, additional, INOOKA, Hajime, additional, TAMURA, Masao, additional, ITOH, Takashi, additional, TAKEUCHI, Ken-ichi, additional, OGATA, Ryoji, additional, KOMURO, Jun, additional, ITOH, Hiroaki, additional, TAKISHIMA, Tamotsu, additional, TANNO, Yasuo, additional, KONNO, Kiyoshi, additional, OHIZUMI, Kotaro, additional, WATANABE, Akira, additional, KASHIWAGI, Makoto, additional, TOGASHI, Hideo, additional, SATO, Hidetaka, additional, HAYASHI, Masato, additional, ITOH, Tsugushi, additional, HAYASHI, Izumi, additional, SEKINE, Osamu, additional, USUDA, Yoshimaru, additional, AOKI, Nobuki, additional, YAMASAKU, Fusanosuke, additional, SUZUKI, Yasutoshi, additional, KATSU, Masataka, additional, ADACHI, Masanori, additional, MASHIMO, Keimei, additional, UKAI, Tetsuro, additional, ITOH, Chizuru, additional, SAITO, Atsushi, additional, MIYAHARA, Tadashi, additional, TANIMOTO, Hiroichi, additional, TACHIBANA, Akio, additional, NAKAMORI, Yoshitaka, additional, CHONABAYASHI, Naohiko, additional, YOSHIMURA, Kunihiko, additional, KABE, Junzaburo, additional, ISHIBASHI, Hiroyoshi, additional, IKEMOTO, Hideo, additional, WATANABE, Kazuyoshi, additional, NAKAGAWA, Keiichi, additional, KOYAMA, Masaru, additional, KIN, Kohjin, additional, UEDA, Masami, additional, IIJIMA, Fukuo, additional, AKIYOSHI, Ryuji, additional, FUNATSU, Yuzo, additional, HIGASHI, Fuyuhiko, additional, KOBAYASHI, Hiroyuki, additional, OSHITANI, Hiroshi, additional, FUJIMORI, Ippei, additional, KOBAYASHI, Yoshio, additional, NAKAMURA, Yasushi, additional, FUKAYA, Kazufuto, additional, TAKAGI, Kenzo, additional, YAMAKAWA, Ikuo, additional, HARA, Michihiro, additional, SATAKE, Tatsuo, additional, TAKEUCHI, Toshihiko, additional, KATO, Masahito, additional, KITAURA, Saburo, additional, HANAKI, Hidekazu, additional, YAMAMOTO, Toshiyuki, additional, SUZUKI, Kanzo, additional, KISHIMOTO, Akihiko, additional, ABE, Youichi, additional, TORIGAI, Katsutaka, additional, OHYAMA, Kaoru, additional, SUZUKI, Kuninori, additional, OHYA, Nobuo, additional, HAYASE, Mitsuru, additional, MAEKAWA, Nobuo, additional, NAKANISHI, Michiyasu, additional, AOKI, Kohei, additional, MATSUBARA, Tsuneo, additional, IKEDA, Nobuaki, additional, IWATA, Takekuni, additional, INABA, Nobuo, additional, TSUJINO, Hiroyuki, additional, OKAMOTO, Yuruko, additional, MAEHARA, Keigo, additional, YOSHIOKA, Muneto, additional, IIDA, Yube, additional, OKUBO, Hiroshi, additional, UEDA, Yoshihiro, additional, MIKI, Fumio, additional, TAKAMATSU, Kenji, additional, MIYAMOTO, Osamu, additional, TSUBURA, Eiro, additional, GOTO, Toshihiro, additional, TAMURA, Masakazu, additional, SOEJIMA, Rinzo, additional, NIKI, Yoshito, additional, WATANABE, Masatoshi, additional, YAMAKIDO, Michio, additional, HAYASHI, Kanoko, additional, SAWAE, Yoshiro, additional, KUSABA, Tomohiro, additional, KASHIWAGI, Seizaburo, additional, UEDA, Akira, additional, OKADA, Kaoru, additional, ONO, Michio, additional, TAKII, Masahide, additional, OTONARI, Takatoshi, additional, HARA, Kohei, additional, YAMAGUCHI, Keizo, additional, SUZUYAMA, Yoji, additional, SHIGENO, Yoshiteru, additional, WATANABE, Koichi, additional, NAGASAWA, Masao, additional, MATSUMOTO, Keizo, additional, SHISHIDO, Harumi, additional, TAKAHASHI, Atsushi, additional, TAKASUGI, Masakazu, additional, TAMAKI, Shigeru, additional, KIMURA, Hisao, additional, ANDO, Masayuki, additional, SUGIMOTO, Mineharu, additional, SUGA, Moritaka, additional, TOKUNAGA, Katsumasa, additional, FUKUDA, Yasutsugu, additional, and TOKUOMI, Haruhiko, additional

Published
1985
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13. Is the reno-protective effect of valsartan dose dependent? A comparative study of 80 and 160 mg day(-1).

Author

Saikawa T, Sasaki J, Biro S, Kono S, Otonari T, and Ikeda Y

Subjects
Aged, Albuminuria drug therapy, Blood Urea Nitrogen, Collagen Type IV urine, Creatinine blood, Diabetes Mellitus, Type 2 drug therapy, Diabetes Mellitus, Type 2 physiopathology, Diabetic Nephropathies drug therapy, Diabetic Nephropathies physiopathology, Female, Humans, Male, Middle Aged, Valine administration & dosage, Valsartan, beta 2-Microglobulin urine, Angiotensin II Type 1 Receptor Blockers administration & dosage, Antihypertensive Agents administration & dosage, Blood Pressure drug effects, Hypertension drug therapy, Kidney drug effects, Tetrazoles administration & dosage, Valine analogs & derivatives
Abstract

Whether the reno-protective effect of angiotensin receptor blockers is dose dependent is unknown for the Japanese population. We sought to elucidate the dose-dependent reno-protective effects of valsartan in Japanese hypertensive patients with albuminuria. This was a multi-center, open-label, parallel-group trial. A total of 181 patients were randomized to receive either 80 (n=89) or 160 mg day(-1) (n=92) of valsartan for 24 weeks. Then, the effects on blood pressure, urinary albumin excretion (UAE), type IV collagen and beta(2)-microglobulin (beta2MG) were determined. Systolic and diastolic blood pressures decreased substantially by almost the same extent in the low-dose and high-dose groups, showing no inter-group difference during the treatment. The UAE value decreased significantly by 35% in both groups. Urinary excretion of beta2MG was significantly decreased in the high-dose group (17%), but not in the low-dose group (13%), although the decrease was not significantly different between the two groups (P=0.74). Urinary excretion of type IV collagen decreased non-significantly by 10% in the low-dose group and by 8% in the high-dose group, showing no significant inter-group difference (P=0.78). Low (80 mg day(-1)) and high (160 mg day(-1)) doses of valsartan showed a similar effect of lowering blood pressure. The high dose of valsartan resulted in a slightly greater decrease in urinary beta2MG, but it was inconclusive whether the high dose was more reno-protective as compared with the low dose.

Published
2010
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