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1. The 2023 yearbook of Neurorestoratology

Author

Huang, Hongyun, Bach, John R., Sharma, Hari Shanker, Chen, Lin, Wu, Ping, Sarnowska, Anna, Otom, Ali, Xue, Mengzhou, Saberi, Hooshang, He, Xijing, Alhawamdeh, Ziad, Kuffler, Damien, Hu, Jianzhong, Siniscalco, Dario, Alvarez, Edgardo O., Li, Mingchang, and Sanberg, Paul R.

Published
2024
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2. Standards for structured reporting of dual-energy X-ray absorptiometry scans: best practice recommendations by the Pan Arab Osteoporosis Society

Author

El Miedany, Yasser, El Gaafary, Maha, Gadallah, Naglaa, Sulimani, Riad, AlAli, Nadia S., Alzoubi, Ziad, Azim, Atef Abdel, Abdulateef, Nizar, Adib, Gemma, Elwy, Mohamed, Al Izzi, Mustafa Khalid, El Maghraoui, Abdellah, Mahran, Safaa, Masri, Basel K., Al Emadi, Samar, Abu-Zaid, Mohammed Hassan, Saba, Elias, Hassan, Waleed, El Rakaawi, Manal, Otom, Ali, and Elwakil, Walaa

Published
2023
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11. Beijing Declaration of International Association of Neurorestoratology (2023 Xi’an Version)

Author

Huang, Hongyun, primary, Chen, Lin, additional, Sanberg, Paul R., additional, Dimitrijevic, Milan, additional, Shetty, Ashok K., additional, Sharma, Hari Shanker, additional, Wu, Ping, additional, Bryukhovetskiy, Andrey, additional, Alzoubi, Ziad M., additional, Chopp, Michael, additional, Young, Wise, additional, Saberi, Hooshang, additional, Moviglia, Gustavo, additional, Sarnowska, Anna, additional, Sharma, Alok, additional, He, Xijing, additional, Muresanu, Dafin F., additional, Jeon, Sang Ryong, additional, Feng, Shiqing, additional, Cho, Kyoung-Suok, additional, Alvarez, Edgardo O., additional, Kuźma-Kozakiewicz, Magdalena, additional, Kuffler, Damien, additional, Otom, Ali, additional, Herrera-Marschitz, Mario, additional, Moniche, Francisco, additional, Koliakos, Georgios, additional, Ao, Qiang, additional, Guo, Xiaodong, additional, von Wild, Klaus R.H., additional, Cheng, Liming, additional, AlZoubi, Adeeb, additional, Zhao, Jianghua, additional, Guo, Xiaoling, additional, Mao, Gengsheng, additional, Han, Fabin, additional, Hu, Yong, additional, Xue, Mengzhou, additional, Song, Jinggui, additional, Zhang, Xinzhong, additional, Chen, Xu, additional, Chen, Lukui, additional, Zheng, Zuncheng, additional, Wang, Dong, additional, Zhang, Wenchuan, additional, Qiao, Liyan, additional, Xiang, Guanghong, additional, Liu, Jing, additional, Zhao, Robert Chunhua, additional, and Zhang, Qiqing, additional

Published
2023
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12. The 2022 yearbook of Neurorestoratology

Author

Huang, Hongyun, primary, Bach, John R., additional, Sharma, Hari Shanker, additional, Saberi, Hooshang, additional, Jeon, Sang Ryong, additional, Guo, Xiaoling, additional, Shetty, Ashok, additional, Hawamdeh, Ziad, additional, Sharma, Alok, additional, Wild, Klaus von, additional, Siniscalco, Dario, additional, Sanberg, Paul R., additional, Hu, Yong, additional, Xue, Mengzhou, additional, Chen, Lin, additional, Han, Fabin, additional, Otom, Ali, additional, Hu, Jianzhong, additional, and Zhang, Qiqing, additional

Published
2023
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13. Beijing declaration of International Association of Neurorestoratology (2023 Xi'an version)

Author

Huang, Hongyun, Chen, Lin, Sanberg, Paul R., Dimitrijevic, Milan, Shetty, Ashok K., Sharma, Hari Shanker, Wu, Ping, Bryukhovetskiy, Andrey, Al-Zoubi, Ziad M., Chopp, Michael, Young, Wise, Saberi, Hooshang, Moviglia, Gustavo, Sarnowska, Anna, Sharma, Alok, He, Xijing, Muresanu, Dafin F., Jeon, Sang Ryong, Feng, Shiqing, Cho, Kyoung-Suok, Alvarez, Edgardo O., Kuzma-Kozakiewicz, Magdalena, Kuffler, Damien, Otom, Ali, Herrera-Marschitz, Mario, Moniche, Francisco, Koliakos, Georgios, Ao, Qiang, Guo, Xiaodong, von Wild, Klaus R. H., Cheng, Liming, Al-Zoubi, Adeeb, Zhao, Jianhua, Guo, Xiaoling, Mao, Gengsheng, Han, Fabin, Hu, Yong, Xue, Mengzhou, Song, Jinggui, Zhang, Xinzhong, Chen, Xu, Chen, Lukui, Zheng, Zuncheng, Wang, Dong, Zhang, Wenchuan, Qiao, Liyan, Xiang, Guanghong, Liu, Jing, Zhao, Robert Chunhua, Zhang, Qiqing, Huang, Hongyun, Chen, Lin, Sanberg, Paul R., Dimitrijevic, Milan, Shetty, Ashok K., Sharma, Hari Shanker, Wu, Ping, Bryukhovetskiy, Andrey, Al-Zoubi, Ziad M., Chopp, Michael, Young, Wise, Saberi, Hooshang, Moviglia, Gustavo, Sarnowska, Anna, Sharma, Alok, He, Xijing, Muresanu, Dafin F., Jeon, Sang Ryong, Feng, Shiqing, Cho, Kyoung-Suok, Alvarez, Edgardo O., Kuzma-Kozakiewicz, Magdalena, Kuffler, Damien, Otom, Ali, Herrera-Marschitz, Mario, Moniche, Francisco, Koliakos, Georgios, Ao, Qiang, Guo, Xiaodong, von Wild, Klaus R. H., Cheng, Liming, Al-Zoubi, Adeeb, Zhao, Jianhua, Guo, Xiaoling, Mao, Gengsheng, Han, Fabin, Hu, Yong, Xue, Mengzhou, Song, Jinggui, Zhang, Xinzhong, Chen, Xu, Chen, Lukui, Zheng, Zuncheng, Wang, Dong, Zhang, Wenchuan, Qiao, Liyan, Xiang, Guanghong, Liu, Jing, Zhao, Robert Chunhua, and Zhang, Qiqing

Published
2023
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14. The 2022 yearbook of neurorestoratology

Author

Huang, Hongyun, Bach, John R., Sharma, Hari Shanker, Saberi, Hooshang, Jeon, Sang Ryong, Guo, Xiaoling, Shetty, Ashok, Hawamdeh, Ziad, Sharma, Alok, von Wild, Klaus, Siniscalco, Dario, Sanberg, Paul R., Hu, Yong, Xue, Mengzhou, Chen, Lin, Han, Fabin, Otom, Ali, Hu, Jianzhong, Zhang, Qiqing, Huang, Hongyun, Bach, John R., Sharma, Hari Shanker, Saberi, Hooshang, Jeon, Sang Ryong, Guo, Xiaoling, Shetty, Ashok, Hawamdeh, Ziad, Sharma, Alok, von Wild, Klaus, Siniscalco, Dario, Sanberg, Paul R., Hu, Yong, Xue, Mengzhou, Chen, Lin, Han, Fabin, Otom, Ali, Hu, Jianzhong, and Zhang, Qiqing

Abstract

There was much progress in the field of Neurorestoratology in the year of 2022. It included highlighting advances in understanding the pathogenesis of neurological diseases, neurorestorative mechanisms, and clinical treatments as compiled in the 2022 yearbook of Neurorestoratology. There is still controversy about whether amyloid b-protein and tau protein deposition are the reasons for or the results of Alzheimer's disease (AD) pathology. The fabricated images in important key articles that speculated on the reasons for AD pathogenesis were found. Cholinergic deficiency and decrease or loss in strength of glutamatergic synapse, limited or failing bidirectional cholinergic upregulation in early cognitive impairment, or progressive posterior-to-anterior cortical cholinergic denervation could result in the appearance of AD. Exploration of neurorestorative mechanisms were found in more detail ways in neuromodulation, immunomodulation, neurogenesis, neural network or circuitry reconstruction, neuroprotection, nervous structural repair, and neuroplasticity. Several kinds of cell therapies for neurological diseases showed neurorestorative effects in open-label and/or non-randomized clinical studies or trials. However, mesenchymal stromal cells and mononuclear cells did not demonstrate neurorestorative effects or improve the quality of life for patients with neurodegenerative diseases or neurotrauma including stroke, spinal cord injury (SCI), and amyotrophic lateral sclerosis in randomized, double-blind, placebo-controlled clinical trials (RDPCTs). Clinical treatments through neurostimulation/neuromodulati on and the brain-computer/ machine interface yielded positive results in AD, Parkinson's disease, stroke, SCI, cerebral palsy, and other diseases in RDPCTs. Neurorestorative surgery, pharmaceutical neurorestorative therapy and other interventions have demonstrated neurorestorative effects for various considered incurable neurological diseases in RDPCTs. Thus, this year, a

Published
2023
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19. The 2019 yearbook of Neurorestoratology

Author

Huang, Hongyun, primary, Chen, Lin, additional, Mao, Gengsheng, additional, Bach, John, additional, Xue, Qun, additional, Han, Fabin, additional, Guo, Xiaoling, additional, Otom, Ali, additional, Chernykh, Elena, additional, Alvarez, Edgardo, additional, Bryukhovetskiy, Andrey, additional, Sarnowaska, Anna, additional, He, Xijing, additional, Dimitrijevic, Milan, additional, Shanti, Ihsan, additional, von Wild, Klaus, additional, Ramón-Cueto, Almudena, additional, Alzoubi, Ziad, additional, Moviglia, Gustavo, additional, Mobasheri, Hamid, additional, Alzoubi, Adeeb, additional, and Zhang, Wenchuan, additional

Published
2020
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20. Clinical Cell Therapy Guidelines for Neurorestoration (IANR/CANR 2017)

Author

Huang, Hongyun, Young, Wise, Chen, Lin, Feng, Shiqing, Al Zoubi, Ziad M., Sharma, Hari Shanker, Saberi, Hooshang, Moviglia, Gustavo A., He, Xijing, Muresanu, Dafin F., Sharma, Alok, Otom, Ali, Andrews, Russell J., Al-Zoubi, Adeeb, Bryukhovetskiy, Andrey S., Chernykh, Elena R., Domanska-Janik, Krystyna, Jafar, Emad, Johnson, W. Eustace, Li, Ying, Li, Daqing, Luan, Zuo, Mao, Gengsheng, Shetty, Ashok K., Siniscalco, Dario, Skaper, Stephen, Sun, Tiansheng, Wang, Yunliang, Wiklund, Lars, Xue, Qun, You, Si-Wei, Zheng, Zuncheng, Dimitrijevic, Milan R., El Masri, W. S., Sanberg, Paul R., Xu, Qunyuan, Luan, Guoming, Chopp, Michael, Cho, Kyoung-Suok, Zhou, Xin-Fu, Wu, Ping, Liu, Kai, Mobasheri, Hamid, Ohtori, Seiji, Tanaka, Hiroyuki, Han, Fabin, Feng, Yaping, Zhang, Shaocheng, Lu, Yingjie, Zhang, Zhicheng, Rao, Yaojian, Tang, Zhouping, Xi, Haitao, Wu, Liang, Shen, Shunji, Xue, Mengzhou, Xiang, Guanghong, Guo, Xiaoling, Yang, Xiaofeng, Hao, Yujun, Hu, Yong, Li, Jinfeng, Ao, Qiang, Wang, Bin, Zhang, Zhiwen, Lu, Ming, Li, Tong, Huang, Hongyun, Young, Wise, Chen, Lin, Feng, Shiqing, Al Zoubi, Ziad M., Sharma, Hari Shanker, Saberi, Hooshang, Moviglia, Gustavo A., He, Xijing, Muresanu, Dafin F., Sharma, Alok, Otom, Ali, Andrews, Russell J., Al-Zoubi, Adeeb, Bryukhovetskiy, Andrey S., Chernykh, Elena R., Domanska-Janik, Krystyna, Jafar, Emad, Johnson, W. Eustace, Li, Ying, Li, Daqing, Luan, Zuo, Mao, Gengsheng, Shetty, Ashok K., Siniscalco, Dario, Skaper, Stephen, Sun, Tiansheng, Wang, Yunliang, Wiklund, Lars, Xue, Qun, You, Si-Wei, Zheng, Zuncheng, Dimitrijevic, Milan R., El Masri, W. S., Sanberg, Paul R., Xu, Qunyuan, Luan, Guoming, Chopp, Michael, Cho, Kyoung-Suok, Zhou, Xin-Fu, Wu, Ping, Liu, Kai, Mobasheri, Hamid, Ohtori, Seiji, Tanaka, Hiroyuki, Han, Fabin, Feng, Yaping, Zhang, Shaocheng, Lu, Yingjie, Zhang, Zhicheng, Rao, Yaojian, Tang, Zhouping, Xi, Haitao, Wu, Liang, Shen, Shunji, Xue, Mengzhou, Xiang, Guanghong, Guo, Xiaoling, Yang, Xiaofeng, Hao, Yujun, Hu, Yong, Li, Jinfeng, Ao, Qiang, Wang, Bin, Zhang, Zhiwen, Lu, Ming, and Li, Tong

Abstract

Cell therapy has been shown to be a key clinical therapeutic option for central nervous system diseases or damage. Standardization of clinical cell therapy procedures is an important task for professional associations devoted to cell therapy. The Chinese Branch of the International Association of Neurorestoratology (IANR) completed the first set of guidelines governing the clinical application of neurorestoration in 2011. The IANR and the Chinese Association of Neurorestoratology (CANR) collaborated to propose the current version "Clinical Cell Therapy Guidelines for Neurorestoration (IANR/CANR 2017)". The IANR council board members and CANR committee members approved this proposal on September 1, 2016, and recommend it to clinical practitioners of cellular therapy. These guidelines include items of cell type nomenclature, cell quality control, minimal suggested cell doses, patient-informed consent, indications for undergoing cell therapy, contraindications for undergoing cell therapy, documentation of procedure and therapy, safety evaluation, efficacy evaluation, policy of repeated treatments, do not charge patients for unproven therapies, basic principles of cell therapy, and publishing responsibility.

Published
2018
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21. Clinical Cell Therapy Guidelines for Neurorestoration (IANR/CANR 2017)

Author

Huang, Hongyun, primary, Young, Wise, additional, Chen, Lin, additional, Feng, Shiqing, additional, Zoubi, Ziad M. Al, additional, Sharma, Hari Shanker, additional, Saberi, Hooshang, additional, Moviglia, Gustavo A., additional, He, Xijing, additional, Muresanu, Dafin F., additional, Sharma, Alok, additional, Otom, Ali, additional, Andrews, Russell J., additional, Al-Zoubi, Adeeb, additional, Bryukhovetskiy, Andrey S., additional, Chernykh, Elena R., additional, Domańska-Janik, Krystyna, additional, Jafar, Emad, additional, Johnson, W. Eustace, additional, Li, Ying, additional, Li, Daqing, additional, Luan, Zuo, additional, Mao, Gengsheng, additional, Shetty, Ashok K., additional, Siniscalco, Dario, additional, Skaper, Stephen, additional, Sun, Tiansheng, additional, Wang, Yunliang, additional, Wiklund, Lars, additional, Xue, Qun, additional, You, Si-Wei, additional, Zheng, Zuncheng, additional, Dimitrijevic, Milan R., additional, Masri, W. S. El, additional, Sanberg, Paul R., additional, Xu, Qunyuan, additional, Luan, Guoming, additional, Chopp, Michael, additional, Cho, Kyoung-Suok, additional, Zhou, Xin-Fu, additional, Wu, Ping, additional, Liu, Kai, additional, Mobasheri, Hamid, additional, Ohtori, Seiji, additional, Tanaka, Hiroyuki, additional, Han, Fabin, additional, Feng, Yaping, additional, Zhang, Shaocheng, additional, Lu, Yingjie, additional, Zhang, Zhicheng, additional, Rao, Yaojian, additional, Tang, Zhouping, additional, Xi, Haitao, additional, Wu, Liang, additional, Shen, Shunji, additional, Xue, Mengzhou, additional, Xiang, Guanghong, additional, Guo, Xiaoling, additional, Yang, Xiaofeng, additional, Hao, Yujun, additional, Hu, Yong, additional, Li, Jinfeng, additional, AO, Qiang, additional, Wang, Bin, additional, Zhang, Zhiwen, additional, Lu, Ming, additional, and Li, Tong, additional

Published
2018
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22. Consensus of Clinical Neurorestorative Progress in Patients With Complete Chronic Spinal Cord Injury

Author

Huang, Hongyun, Sun, Tiansheng, Chen, Lin, Moviglia, Gustavo, Chernykh, Elena, von Wild, Klaus, Deda, Haluk, Kang, Kyung-Sun, Kumar, Anand, Jeon, Sang Ryong, Zhang, Shaocheng, Brunelli, Giorgio, Bohbot, Albert, Soler, Maria Dolors, Li, Jianjun, Cristante, Alexandre Fogaca, Xi, Haitao, Onose, Gelu, Kern, Helmut, Carraro, Ugo, Saberi, Hooshang, Sharma, Hari Shanker, Sharma, Alok, He, Xijing, Muresanu, Dafin, Feng, Shiqing, Otom, Ali, Wang, Dajue, Iwatsu, Koichi, Lu, Jike, Al-Zoubi, Adeeb, Huang, Hongyun, Sun, Tiansheng, Chen, Lin, Moviglia, Gustavo, Chernykh, Elena, von Wild, Klaus, Deda, Haluk, Kang, Kyung-Sun, Kumar, Anand, Jeon, Sang Ryong, Zhang, Shaocheng, Brunelli, Giorgio, Bohbot, Albert, Soler, Maria Dolors, Li, Jianjun, Cristante, Alexandre Fogaca, Xi, Haitao, Onose, Gelu, Kern, Helmut, Carraro, Ugo, Saberi, Hooshang, Sharma, Hari Shanker, Sharma, Alok, He, Xijing, Muresanu, Dafin, Feng, Shiqing, Otom, Ali, Wang, Dajue, Iwatsu, Koichi, Lu, Jike, and Al-Zoubi, Adeeb

Abstract

Currently, there is a lack of effective therapeutic methods to restore neurological function for chronic complete spinal cord injury (SCI) by conventional treatment. Neurorestorative strategies with positive preclinical results have been translated to the clinic, and some patients have gotten benefits and their quality of life has improved. These strategies include cell therapy, neurostimulation or neuromodulation, neuroprosthesis, neurotization or nerve bridging, and neurorehabilitation. The aim of this consensus by 31 experts from 20 countries is to show the objective evidence of clinical neurorestoration for chronic complete SCI by the mentioned neurorestorative strategies. Complete chronic SCI patients are no longer told, "nothing can be done." The clinical translation of more effective preclinical neurorestorative strategies should be encouraged as fast as possible in order to benefit patients with incurable CNS diseases. This manuscript is published as part of the International Association of Neurorestoratology (IANR) special issue of Cell Transplantation.

Published
2014
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25. Consensus of Clinical Neurorestorative Progress in Patients with Complete Chronic Spinal Cord Injury

Author

Huang, Hongyun, primary, Sun, Tiansheng, additional, Chen, Lin, additional, Moviglia, Gustavo, additional, Chernykh, Elena, additional, Von Wild, Klaus, additional, Deda, Haluk, additional, Kang, Kyung-Sun, additional, Kumar, Anand, additional, Jeon, Sang Ryong, additional, Zhang, Shaocheng, additional, Brunelli, Giorgio, additional, Bohbot, Albert, additional, Soler, Maria Dolors, additional, Li, Jianjun, additional, Cristante, Alexandre Fogaça, additional, Xi, Haitao, additional, Onose, Gelu, additional, Kern, Helmut, additional, Carraro, Ugo, additional, Saberi, Hooshang, additional, Sharma, Hari Shanker, additional, Sharma, Alok, additional, He, Xijing, additional, Muresanu, Dafin, additional, Feng, Shiqing, additional, Otom, Ali, additional, Wang, Dajue, additional, Iwatsu, Koichi, additional, Lu, Jike, additional, and Al-Zoubi, Adeeb, additional

Published
2014
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27. THE AWARENESS OF PARENTS OF THE TIME OF ERUPTION OF FIRST PERMANENT MOLAR AND CARIES PREVALENCE IN THIS TOOTH IN CHILDREN IN THE SOUTH OF JORDAN.

Author

JARADAT, TAGREED, GHOZLAN, MOA'TH, SHOWEITER, MARWAN, OTOM, ALI, and KANA'AN, NADEEM

Subjects
PARENTS, MOLARS, DENTAL caries research, CHILDREN, TEETH
Abstract

The main aim of this study was to assess the awareness of parents of the time of eruption of First Permanent Molar and the prevalence of caries in this tooth in children in the south of Jordan. 150 patients (85 females, 65 males) aged between 5-12 years, with mean age (7.6) years formed the study group. Each of them had at least one first permanent molar erupted. They were examined oraly and their parents were interviewed and asked whether they know at what age First Permanent Molar erupts. 82% of the interviewed parents were unaware about the time of eruption of first permanent molar. 54% of the examined children had one or more unsound first permanent molar. 44% of the examined first permanent molars were unsound. DMFT for the First Permanent Molar was (0.17), (0.64), (1.85), and (2.63) at 6, 7, 8 and 9 year old respectively. Parents had little knowledge about the time of eruption of first permanent molar, and, hence, its importance. And there was high caries prevalence in these teeth. [ABSTRACT FROM AUTHOR]

Published
2013

28. Advances in Neurorestoratology-Current status and future developments.

Author

Huang H, Ramon-Cueto A, El Masri W, Moviglia GA, Saberi H, Sharma HS, Otom A, Chen L, Siniscalco D, and Sarnowska A

Subjects
Humans, Nerve Regeneration physiology, Neurogenesis, Neuronal Plasticity, Central Nervous System, Nervous System Diseases therapy
Abstract

Neurorestoratology constitutes a novel discipline aimed at the restoration of damaged neural structures and impaired neurological functions. This area of knowledge integrates and compiles all concepts and strategies dealing with the neurorestoration. Although currently, this discipline has already been well recognized by physicians and scientists throughout the world, this article aimed at broadening its knowledge to the academic circle and the public society. Here we shortly introduced why and how Neurorestoratology was born since the fact that the central nervous system (CNS) can be repaired and the subsequent scientific evidence of the neurorestorative mechanisms behind, such as neurostimulation or neuromodulation, neuroprotection, neuroplasticity, neurogenesis, neuroregeneration or axonal regeneration or sprouting, neuroreplacement, loop reconstruction, remyelination, immunoregulation, angiogenesis or revascularization, and others. The scope of this discipline is the improvement of therapeutic approaches for neurological diseases and the development of neurorestorative strategies through the comprehensive efforts of experts in the different areas and all articulated by the associations of Neurorestoratology and its journals. Strikingly, this article additionally explores the "state of art" of the Neurorestoratology field. This includes the development process of the discipline, the achievements and advances of novel neurorestorative treatments, the most efficient procedures exploring and evaluating outcome after the application of pioneer therapies, all the joining of a multidisciplinary expert associations and the specialized journals being more and more impact. We believe that in a near future, this discipline will evolve fast, leading to a general application of cell-based comprehensive neurorestorative treatments to fulfill functional recovery demands for patients with neurological deficits or dysfunctions., (Copyright © 2023. Published by Elsevier Inc.)

Published
2023
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29. Pan Arab Osteoporosis Society Guidelines for Osteoporosis Management.

Author

Jassim NA, Adib G, Abdul Rahman YA, Gorial FI, Maghraoui A, Al Suhaili AR, Murtaji A, Otom A, Masri B, Saba E, Badran F, Maalouf G, Saleh J, El Muntaser K, Zakraoui L, Al Izzi M, Al Ali N, Sulaimani R, Abdul Majeed S, and Al Emadi S

Abstract

Osteoporosis is the most common bone disease in humans. With its related fragility fracture, it represents a major public health problem in our region, with a significant medical and socio-economic burden. The high prevalence rate of vitamin D deficiency, the increase in life expectancy, the low socioeconomic level and the significant restriction to access to health care in some countries represent the major causes for the increasing prevalence of osteoporosis and incidence of fragility fractures in the Arabic countries. Bone mineral density (BMD) assessment is the gold standard to diagnose osteoporosis. However, a clinical diagnosis of osteoporosis may be made in the presence of a fragility fracture, without BMD measurement. Dual energy x-ray absorptiometry (DXA) is the preferred method for screening bone mineral density. For screening site of measurement, DXA of hip and spine is suggested. BMD assessment is recommended in all women 65 years of age and older and men 70 and older regardless of risk factors. Younger subjects with clinical risk factors and persons with clinical evidence of osteoporosis or diseases leading to osteoporosis should also be screened. These guidelines are aimed to provide to health care professionals in the region of an updated process for the diagnosis and treatment of osteoporosis. It includes risk factors for osteoporosis and the indications for screening, diagnosis of osteoporosis, treatment of osteoporosis in postmenopausal and premenopausal women, and men; in addition to prevention and treatment of glucocorticoid-induced osteoporosis., (© 2017 The Mediterranean Journal of Rheumatology (MJR).)

Published
2017
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30. Botulinum toxin type-A in the management of spastic equinovarus deformity after stroke. Comparison of 2 injection techniques.

Author

Otom AH, Al-Khawaja IM, and Al-Quliti KW

Subjects
Clubfoot etiology, Female, Humans, Injections, Intramuscular methods, Male, Middle Aged, Muscle Spasticity etiology, Neuromuscular Agents administration & dosage, Retrospective Studies, Treatment Outcome, Botulinum Toxins, Type A administration & dosage, Clubfoot drug therapy, Muscle Spasticity drug therapy, Muscle, Skeletal drug effects, Stroke complications
Abstract

Objective: To retrospectively compare 2 injection techniques in the management of spastic equinovarus deformity after stroke., Methods: Patients with stroke were seen at King Hussein Medical Center, Amman, Jordan between January and December 2009. The study design involved an open label retrospective analysis of medical records of 2 groups of comparable age and onset of first stroke. Botulinum toxin was injected into the calf muscles at 2 sites in group I (12 patients) and 4 sites in group II (14 patients). Functional gain was evaluated by the time to walk 10 meters at month one, 3, and 6 compared with baseline., Results: There was significant improvement in walking time in each study group. However, there was no significant difference between the 2 groups as measured by the 10-meter walking time., Conclusion: Fewer injection sites would minimize patient discomfort and possibly the production of antibodies, yielding similar therapeutic effects.

Published
2014

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