170 results on '"Ota, Vanessa Kiyomi"'
Search Results
2. miR-9-5p is Downregulated in Serum Extracellular Vesicles of Patients Treated with Biperiden After Traumatic Brain Injury
- Author
-
Villena-Rueda, Beatriz Enguidanos, Kajitani, Gustavo Satoru, Ota, Vanessa Kiyomi, Honorato-Mauer, Jessica, Santoro, Marcos Leite, Bugiga, Amanda Victória Gomes, Rosa, Joice Santos, Asprino, Paula Fontes, Meneghetti, Paula, Torrecilhas, Ana Claudia, Intasqui, Paula, Bertolla, Ricardo Pimenta, Foresti, Maira Licia, da Graça Naffah-Mazzacoratti, Maria, de Moraes Mello, Luiz Eugênio Araújo, and Belangero, Sintia Iole
- Published
- 2024
- Full Text
- View/download PDF
3. Alterations in microRNA of extracellular vesicles associated with major depression, attention-deficit/hyperactivity and anxiety disorders in adolescents
- Author
-
Honorato-Mauer, Jessica, Xavier, Gabriela, Ota, Vanessa Kiyomi, Chehimi, Samar Nasser, Mafra, Fernanda, Cuóco, Cássia, Ito, Lucas Toshio, Ormond, Rafaella, Asprino, Paula Fontes, Oliveira, Adrielle, Bugiga, Amanda Victoria Gomes, Torrecilhas, Ana Claudia, Bressan, Rodrigo, Manfro, Gisele Gus, Miguel, Euripedes Constantino, Rohde, Luis Augusto, Pan, Pedro Mario, Salum, Giovanni Abrahão, Pellegrino, Renata, Belangero, Sintia, and Santoro, Marcos Leite
- Published
- 2023
- Full Text
- View/download PDF
4. Systems-Level Analysis of Genetic Variants Reveals Functional and Spatiotemporal Context in Treatment-resistant Schizophrenia
- Author
-
Talarico, Fernanda, Costa, Giovany Oliveira, Ota, Vanessa Kiyomi, Santoro, Marcos Leite, Noto, Cristiano, Gadelha, Ary, Bressan, Rodrigo, Azevedo, Hatylas, and Belangero, Sintia Iole
- Published
- 2022
- Full Text
- View/download PDF
5. Mapping genomic loci implicates genes and synaptic biology in schizophrenia
- Author
-
Trubetskoy, Vassily, Pardiñas, Antonio F., Qi, Ting, Panagiotaropoulou, Georgia, Awasthi, Swapnil, Bigdeli, Tim B., Bryois, Julien, Chen, Chia-Yen, Dennison, Charlotte A., Hall, Lynsey S., Lam, Max, Watanabe, Kyoko, Frei, Oleksandr, Ge, Tian, Harwood, Janet C., Koopmans, Frank, Magnusson, Sigurdur, Richards, Alexander L., Sidorenko, Julia, Wu, Yang, Zeng, Jian, Grove, Jakob, Kim, Minsoo, Li, Zhiqiang, Voloudakis, Georgios, Zhang, Wen, Adams, Mark, Agartz, Ingrid, Atkinson, Elizabeth G., Agerbo, Esben, Al Eissa, Mariam, Albus, Margot, Alexander, Madeline, Alizadeh, Behrooz Z., Alptekin, Köksal, Als, Thomas D., Amin, Farooq, Arolt, Volker, Arrojo, Manuel, Athanasiu, Lavinia, Azevedo, Maria Helena, Bacanu, Silviu A., Bass, Nicholas J., Begemann, Martin, Belliveau, Richard A., Bene, Judit, Benyamin, Beben, Bergen, Sarah E., Blasi, Giuseppe, Bobes, Julio, Bonassi, Stefano, Braun, Alice, Bressan, Rodrigo Affonseca, Bromet, Evelyn J., Bruggeman, Richard, Buckley, Peter F., Buckner, Randy L., Bybjerg-Grauholm, Jonas, Cahn, Wiepke, Cairns, Murray J., Calkins, Monica E., Carr, Vaughan J., Castle, David, Catts, Stanley V., Chambert, Kimberley D., Chan, Raymond C. K., Chaumette, Boris, Cheng, Wei, Cheung, Eric F. C., Chong, Siow Ann, Cohen, David, Consoli, Angèle, Cordeiro, Quirino, Costas, Javier, Curtis, Charles, Davidson, Michael, Davis, Kenneth L., de Haan, Lieuwe, Degenhardt, Franziska, DeLisi, Lynn E., Demontis, Ditte, Dickerson, Faith, Dikeos, Dimitris, Dinan, Timothy, Djurovic, Srdjan, Duan, Jubao, Ducci, Giuseppe, Dudbridge, Frank, Eriksson, Johan G., Fañanás, Lourdes, Faraone, Stephen V., Fiorentino, Alessia, Forstner, Andreas, Frank, Josef, Freimer, Nelson B., Fromer, Menachem, Frustaci, Alessandra, Gadelha, Ary, Genovese, Giulio, Gershon, Elliot S., Giannitelli, Marianna, Giegling, Ina, Giusti-Rodríguez, Paola, Godard, Stephanie, Goldstein, Jacqueline I., González Peñas, Javier, González-Pinto, Ana, Gopal, Srihari, Gratten, Jacob, Green, Michael F., Greenwood, Tiffany A., Guillin, Olivier, Gülöksüz, Sinan, Gur, Raquel E., Gur, Ruben C., Gutiérrez, Blanca, Hahn, Eric, Hakonarson, Hakon, Haroutunian, Vahram, Hartmann, Annette M., Harvey, Carol, Hayward, Caroline, Henskens, Frans A., Herms, Stefan, Hoffmann, Per, Howrigan, Daniel P., Ikeda, Masashi, Iyegbe, Conrad, Joa, Inge, Julià, Antonio, Kähler, Anna K., Kam-Thong, Tony, Kamatani, Yoichiro, Karachanak-Yankova, Sena, Kebir, Oussama, Keller, Matthew C., Kelly, Brian J., Khrunin, Andrey, Kim, Sung-Wan, Klovins, Janis, Kondratiev, Nikolay, Konte, Bettina, Kraft, Julia, Kubo, Michiaki, Kučinskas, Vaidutis, Kučinskiene, Zita Ausrele, Kusumawardhani, Agung, Kuzelova-Ptackova, Hana, Landi, Stefano, Lazzeroni, Laura C., Lee, Phil H., Legge, Sophie E., Lehrer, Douglas S., Lencer, Rebecca, Lerer, Bernard, Li, Miaoxin, Lieberman, Jeffrey, Light, Gregory A., Limborska, Svetlana, Liu, Chih-Min, Lönnqvist, Jouko, Loughland, Carmel M., Lubinski, Jan, Luykx, Jurjen J., Lynham, Amy, Macek, Jr, Milan, Mackinnon, Andrew, Magnusson, Patrik K. E., Maher, Brion S., Maier, Wolfgang, Malaspina, Dolores, Mallet, Jacques, Marder, Stephen R., Marsal, Sara, Martin, Alicia R., Martorell, Lourdes, Mattheisen, Manuel, McCarley, Robert W., McDonald, Colm, McGrath, John J., Medeiros, Helena, Meier, Sandra, Melegh, Bela, Melle, Ingrid, Mesholam-Gately, Raquelle I., Metspalu, Andres, Michie, Patricia T., Milani, Lili, Milanova, Vihra, Mitjans, Marina, Molden, Espen, Molina, Esther, Molto, María Dolores, Mondelli, Valeria, Moreno, Carmen, Morley, Christopher P., Muntané, Gerard, Murphy, Kieran C., Myin-Germeys, Inez, Nenadić, Igor, Nestadt, Gerald, Nikitina-Zake, Liene, Noto, Cristiano, Nuechterlein, Keith H., O’Brien, Niamh Louise, O’Neill, F. Anthony, Oh, Sang-Yun, Olincy, Ann, Ota, Vanessa Kiyomi, Pantelis, Christos, Papadimitriou, George N., Parellada, Mara, Paunio, Tiina, Pellegrino, Renata, Periyasamy, Sathish, Perkins, Diana O., Pfuhlmann, Bruno, Pietiläinen, Olli, Pimm, Jonathan, Porteous, David, Powell, John, Quattrone, Diego, Quested, Digby, Radant, Allen D., Rampino, Antonio, Rapaport, Mark H., Rautanen, Anna, Reichenberg, Abraham, Roe, Cheryl, Roffman, Joshua L., Roth, Julian, Rothermundt, Matthias, Rutten, Bart P. F., Saker-Delye, Safaa, Salomaa, Veikko, Sanjuan, Julio, Santoro, Marcos Leite, Savitz, Adam, Schall, Ulrich, Scott, Rodney J., Seidman, Larry J., Sharp, Sally Isabel, Shi, Jianxin, Siever, Larry J., Sigurdsson, Engilbert, Sim, Kang, Skarabis, Nora, Slominsky, Petr, So, Hon-Cheong, Sobell, Janet L., Söderman, Erik, Stain, Helen J., Steen, Nils Eiel, Steixner-Kumar, Agnes A., Stögmann, Elisabeth, Stone, William S., Straub, Richard E., Streit, Fabian, Strengman, Eric, Stroup, T. Scott, Subramaniam, Mythily, Sugar, Catherine A., Suvisaari, Jaana, Svrakic, Dragan M., Swerdlow, Neal R., Szatkiewicz, Jin P., Ta, Thi Minh Tam, Takahashi, Atsushi, Terao, Chikashi, Thibaut, Florence, Toncheva, Draga, Tooney, Paul A., Torretta, Silvia, Tosato, Sarah, Tura, Gian Battista, Turetsky, Bruce I., Üçok, Alp, Vaaler, Arne, van Amelsvoort, Therese, van Winkel, Ruud, Veijola, Juha, Waddington, John, Walter, Henrik, Waterreus, Anna, Webb, Bradley T., Weiser, Mark, Williams, Nigel M., Witt, Stephanie H., Wormley, Brandon K., Wu, Jing Qin, Xu, Zhida, Yolken, Robert, Zai, Clement C., Zhou, Wei, Zhu, Feng, Zimprich, Fritz, Atbaşoğlu, Eşref Cem, Ayub, Muhammad, Benner, Christian, Bertolino, Alessandro, Black, Donald W., Bray, Nicholas J., Breen, Gerome, Buccola, Nancy G., Byerley, William F., Chen, Wei J., Cloninger, C. Robert, Crespo-Facorro, Benedicto, Donohoe, Gary, Freedman, Robert, Galletly, Cherrie, Gandal, Michael J., Gennarelli, Massimo, Hougaard, David M., Hwu, Hai-Gwo, Jablensky, Assen V., McCarroll, Steven A., Moran, Jennifer L., Mors, Ole, Mortensen, Preben B., Müller-Myhsok, Bertram, Neil, Amanda L., Nordentoft, Merete, Pato, Michele T., Petryshen, Tracey L., Pirinen, Matti, Pulver, Ann E., Schulze, Thomas G., Silverman, Jeremy M., Smoller, Jordan W., Stahl, Eli A., Tsuang, Debby W., Vilella, Elisabet, Wang, Shi-Heng, Xu, Shuhua, Adolfsson, Rolf, Arango, Celso, Baune, Bernhard T., Belangero, Sintia Iole, Børglum, Anders D., Braff, David, Bramon, Elvira, Buxbaum, Joseph D., Campion, Dominique, Cervilla, Jorge A., Cichon, Sven, Collier, David A., Corvin, Aiden, Curtis, David, Forti, Marta Di, Domenici, Enrico, Ehrenreich, Hannelore, Escott-Price, Valentina, Esko, Tõnu, Fanous, Ayman H., Gareeva, Anna, Gawlik, Micha, Gejman, Pablo V., Gill, Michael, Glatt, Stephen J., Golimbet, Vera, Hong, Kyung Sue, Hultman, Christina M., Hyman, Steven E., Iwata, Nakao, Jönsson, Erik G., Kahn, René S., Kennedy, James L., Khusnutdinova, Elza, Kirov, George, Knowles, James A., Krebs, Marie-Odile, Laurent-Levinson, Claudine, Lee, Jimmy, Lencz, Todd, Levinson, Douglas F., Li, Qingqin S., Liu, Jianjun, Malhotra, Anil K., Malhotra, Dheeraj, McIntosh, Andrew, McQuillin, Andrew, Menezes, Paulo R., Morgan, Vera A., Morris, Derek W., Mowry, Bryan J., Murray, Robin M., Nimgaonkar, Vishwajit, Nöthen, Markus M., Ophoff, Roel A., Paciga, Sara A., Palotie, Aarno, Pato, Carlos N., Qin, Shengying, Rietschel, Marcella, Riley, Brien P., Rivera, Margarita, Rujescu, Dan, Saka, Meram C., Sanders, Alan R., Schwab, Sibylle G., Serretti, Alessandro, Sham, Pak C., Shi, Yongyong, St Clair, David, Stefánsson, Hreinn, Stefansson, Kari, Tsuang, Ming T., van Os, Jim, Vawter, Marquis P., Weinberger, Daniel R., Werge, Thomas, Wildenauer, Dieter B., Yu, Xin, Yue, Weihua, Holmans, Peter A., Pocklington, Andrew J., Roussos, Panos, Vassos, Evangelos, Verhage, Matthijs, Visscher, Peter M., Yang, Jian, Posthuma, Danielle, Andreassen, Ole A., Kendler, Kenneth S., Owen, Michael J., Wray, Naomi R., Daly, Mark J., Huang, Hailiang, Neale, Benjamin M., Sullivan, Patrick F., Ripke, Stephan, Walters, James T. R., and O’Donovan, Michael C.
- Published
- 2022
- Full Text
- View/download PDF
6. The impact of neighborhood context on telomere length: A systematic review
- Author
-
Coimbra, Bruno Messina, Carvalho, Carolina Muniz, van Zuiden, Mirjam, Williamson, Rachel E., Ota, Vanessa Kiyomi, Mello, Andrea Feijó, Belangero, Sintia Iole, Olff, Miranda, and Mello, Marcelo Feijó
- Published
- 2022
- Full Text
- View/download PDF
7. Aging biological markers in a cohort of antipsychotic-naïve first-episode psychosis patients
- Author
-
Talarico, Fernanda, Xavier, Gabriela, Ota, Vanessa Kiyomi, Spindola, Leticia M., Maurya, Pawan Kumar, Tempaku, Priscila Farias, Moretti, Patrícia S., Gadelha, Ary, Noto, Mariane, Noto, Cristiano, Cordeiro, Quirino, Bressan, Rodrigo A., de Jong, Simone, Santoro, Marcos L., Breen, Gerome, and Belangero, Sintia I.
- Published
- 2021
- Full Text
- View/download PDF
8. BDNF in antipsychotic naive first episode psychosis: Effects of risperidone and the immune-inflammatory response system
- Author
-
Noto, Mariane Nunes, Maes, Michael, Vargas Nunes, Sandra Odebrecht, Ota, Vanessa Kiyomi, Cavalcante, Daniel, Oliveira, Giovany, Rossaneis, Ana C., Verri, Waldiceu A., Jr., Cordeiro, Quirino, Belangero, Sintia Iole, Gadelha, Ary, Noto, Cristiano, and Bressan, Rodrigo Affonseca
- Published
- 2021
- Full Text
- View/download PDF
9. Association between polymorphism in gene related to the dopamine circuit and motivations for drinking in patients with alcohol use disorder
- Author
-
Céspedes, Isabel Cristina, Ota, Vanessa Kiyomi, Mazzotti, Diego Robles, Wscieklica, Tatiana, Conte, Rafael, Galduróz, José Carlos Fernandes, Varela, Patrícia, Pesquero, João Bosco, and Souza-Formigoni, Maria Lucia Oliveira
- Published
- 2021
- Full Text
- View/download PDF
10. A systematic review on the effects of social discrimination on telomere length
- Author
-
Coimbra, Bruno Messina, Carvalho, Carolina Muniz, Ota, Vanessa Kiyomi, Vieira-Fonseca, Tamiris, Bugiga, Amanda, Mello, Andrea Feijó, Mello, Marcelo Feijó, and Belangero, Sintia Iole
- Published
- 2020
- Full Text
- View/download PDF
11. miR-9-5p is downregulated in serum extracellular vesicles of patients treated with biperiden after traumatic brain injury
- Author
-
Villena-Rueda, Beatriz Enguidanos, primary, Kajitani, Gustavo, additional, Ota, Vanessa Kiyomi, additional, Honorato-Mauer, Jessica, additional, Santoro, Marcos Leite, additional, Bugiga, Amanda Victória Gomes, additional, Rosa, Joice Santos, additional, Asprino, Paula Fontes, additional, Torrecilhas, Ana Claudia Trocoli, additional, Intasqui, Paula, additional, Bertolla, Ricardo Pimenta, additional, Foresti, Maira Lucia, additional, Naffah-Mazzacoratti, Maria Graça, additional, Mello, Luiz Eugênio Araújo Moraes, additional, and Belangero, Sintia Iole, additional
- Published
- 2023
- Full Text
- View/download PDF
12. Activation of the immune-inflammatory response system and the compensatory immune-regulatory system in antipsychotic naive first episode psychosis
- Author
-
Noto, Mariane Nunes, Maes, Michael, Nunes, Sandra Odebrecht Vargas, Ota, Vanessa Kiyomi, Rossaneis, Ana C., Verri, Waldiceu A., Jr, Cordeiro, Quirino, Belangero, Sintia Iole, Gadelha, Ary, Bressan, Rodrigo Affonseca, and Noto, Cristiano
- Published
- 2019
- Full Text
- View/download PDF
13. F2. LONG-TERM EFFECTS OF ADVERSE CHILDHOOD EXPERIENCES ON THE MICRORNA PROFILE OF WOMEN AND THEIR NEWBORNS
- Author
-
Kajitani, Gustavo, primary, Rosa, Joice, additional, Micali, Danilo, additional, Ota, Vanessa Kiyomi, additional, Mercuri, Rafael Luiz Vieira, additional, Bugiga, Amanda Victória Gomes, additional, Silva, Ivaldo, additional, Milani, Ana Carolina Coelho, additional, Parente, Camilla Correia, additional, Asprino, Paula Fontes, additional, Galante, Pedro Alexandre Favoretto, additional, Duarte, Cristiane Seixas, additional, Posner, Jonathan, additional, Jackowski, Andrea Parolin, additional, and Belangero, Síntia Iole, additional
- Published
- 2023
- Full Text
- View/download PDF
14. Effects of the brain-derived neurotropic factor variant Val66Met on cortical structure in late childhood and early adolescence
- Author
-
de Araujo, Celia Maria, Zugman, Andre, Swardfager, Walter, Belangero, Sintia Iole Nogueira, Ota, Vanessa Kiyomi, Spindola, Leticia Maria, Hakonarson, Hakon, Pellegrino, Renata, Gadelha, Ary, Salum, Giovanni Abrahão, Pan, Pedro Mario, de Moura, Luciana Monteiro, Del Aquilla, Marco, Picon, Felipe Almeida, Amaro, Edson, Jr., Sato, João Ricardo, Brietzke, Elisa, Grassi-Oliveira, Rodrigo, Rohde, Luis Augusto P., Miguel, Euripedes Constantino, Bressan, Rodrigo A., and Jackowski, Andrea Parolin
- Published
- 2018
- Full Text
- View/download PDF
15. Leukocyte telomere length variation in different stages of schizophrenia
- Author
-
Maurya, Pawan Kumar, Rizzo, Lucas Bortolotto, Xavier, Gabriela, Tempaku, Priscila Farias, Ota, Vanessa Kiyomi, Santoro, Marcos L., Spíndola, Letícia M., Moretti, Patrícia S., Mazzotti, Diego R., Gadelha, Ary, Gouvea, Eduardo S., Noto, Cristiano, Maes, Michael, Cordeiro, Quirino, Bressan, Rodrigo A., Brietzke, Elisa, and Belangero, Sintia Iole
- Published
- 2018
- Full Text
- View/download PDF
16. Gene expression changes associated with trajectories of psychopathology in a longitudinal cohort of children and adolescents
- Author
-
Ota, Vanessa Kiyomi, Santoro, Marcos Leite, Spindola, Leticia Maria, Pan, Pedro Mario, Simabucuro, Andressa, Xavier, Gabriela, Vieira-Fonseca, Tamiris, Zanardo, Evelin Aline, dos Santos, Felipe Rodolfo Camargo, Schäfer, Julia Luiza, Kulikowski, Leslie Domenici, Galante, Pedro A. F., Asprino, Paula Fontes, Brietzke, Elisa, Grassi-Oliveira, Rodrigo, Rohde, Luis Augusto, Miguel, Euripedes Constantino, Gadelha, Ary, Mari, Jair Jesus, Bressan, Rodrigo Affonseca, Salum, Giovanni Abrahao, and Belangero, Sintia Iole
- Published
- 2020
- Full Text
- View/download PDF
17. Gene expression in blood of children and adolescents: Mediation between childhood maltreatment and major depressive disorder
- Author
-
Spindola, Leticia Maria, Pan, Pedro Mario, Moretti, Patricia Natalia, Ota, Vanessa Kiyomi, Santoro, Marcos Leite, Cogo-Moreira, Hugo, Gadelha, Ary, Salum, Giovanni, Manfro, Gisele Gus, Mari, Jair Jesus, Brentani, Helena, Grassi-Oliveira, Rodrigo, Brietzke, Elisa, Miguel, Euripedes Constantino, Rohde, Luis Augusto, Sato, João Ricardo, Bressan, Rodrigo Affonseca, and Belangero, Sintia Iole
- Published
- 2017
- Full Text
- View/download PDF
18. Genome-wide investigation of schizophrenia associated plasma Ndel1 enzyme activity
- Author
-
Gadelha, Ary, Coleman, Jonathan, Breen, Gerome, Mazzoti, Diego Robles, Yonamine, Camila M., Pellegrino, Renata, Ota, Vanessa Kiyomi, Belangero, Sintia Iole, Glessner, Joseph, Sleiman, Patrick, Hakonarson, Hakon, Hayashi, Mirian A.F., and Bressan, Rodrigo A.
- Published
- 2016
- Full Text
- View/download PDF
19. Increased expression of NDEL1 and MBP genes in the peripheral blood of antipsychotic-naïve patients with first-episode psychosis
- Author
-
Ota, Vanessa Kiyomi, Noto, Cristiano, Santoro, Marcos Leite, Spindola, Leticia Maria, Gouvea, Eduardo Sauerbronn, Carvalho, Carolina Muniz, Santos, Camila Maurício, Xavier, Gabriela, Higuchi, Cinthia Hiroko, Yonamine, Camila, Moretti, Patricia Natalia, Abílio, Vanessa Costhek, Hayashi, Mirian Akemi F., Brietzke, Elisa, Gadelha, Ary, Cordeiro, Quirino, Bressan, Rodrigo Affonseca, and Belangero, Sintia Iole
- Published
- 2015
- Full Text
- View/download PDF
20. Gene expression over the course of schizophrenia: from clinical high-risk for psychosis to chronic stages
- Author
-
Ota, Vanessa Kiyomi, Moretti, Patricia Natalia, Santoro, Marcos Leite, Talarico, Fernanda, Spindola, Leticia Maria, Xavier, Gabriela, Carvalho, Carolina Muniz, Marques, Diogo Ferri, Costa, Giovany Oliveira, Pellegrino, Renata, de Jong, Simone, Cordeiro, Quirino, Hakonarson, Hakon, Breen, Gerome, Noto, Cristiano, Bressan, Rodrigo Affonseca, Gadelha, Ary, Jesus Mari, Jair de, and Belangero, Sintia I.
- Published
- 2019
- Full Text
- View/download PDF
21. Oxidative stress in drug naïve first episode psychosis and antioxidant effects of risperidone
- Author
-
Noto, Cristiano, Ota, Vanessa Kiyomi, Gadelha, Ary, Noto, Mariane Nunes, Barbosa, Décio Sabbatini, Bonifácio, Kamila Landucci, Nunes, Sandra Odebrecht, Cordeiro, Quirino, Belangero, Sintia Iole, Bressan, Rodrigo Affonseca, Maes, Michael, and Brietzke, Elisa
- Published
- 2015
- Full Text
- View/download PDF
22. Lowered paraoxonase 1 (PON1) activity is associated with increased cytokine levels in drug naïve first episode psychosis
- Author
-
Brinholi, Francis Fregonesi, Noto, Cristiano, Maes, Michael, Bonifácio, Kamila Landucci, Brietzke, Elisa, Ota, Vanessa Kiyomi, Gadelha, Ary, Cordeiro, Quirino, Belangero, Sintia Iole, Bressan, Rodrigo Affonseca, Vargas, Heber Odebrecht, Higachi, Luciana, de Farias, Carine Coneglian, Moreira, Estefânia Gastaldello, and Barbosa, Décio Sabbatini
- Published
- 2015
- Full Text
- View/download PDF
23. Effects of depression on the cytokine profile in drug naïve first-episode psychosis
- Author
-
Noto, Cristiano, Ota, Vanessa Kiyomi, Santoro, Marcos Leite, Ortiz, Bruno B., Rizzo, Lucas B., Higuchi, Cinthia Hiroko, Cordeiro, Quirino, Belangero, Sintia Iole, Bressan, Rodrigo Affonseca, Gadelha, Ary, Maes, Michael, and Brietzke, Elisa
- Published
- 2015
- Full Text
- View/download PDF
24. Expression profile of neurotransmitter receptor and regulatory genes in the prefrontal cortex of spontaneously hypertensive rats: Relevance to neuropsychiatric disorders
- Author
-
Santoro, Marcos Leite, Santos, Camila Maurício, Ota, Vanessa Kiyomi, Gadelha, Ary, Stilhano, Roberta Sessa, Diana, Mariana Cepollaro, Silva, Patrícia Natália, Spíndola, Letícia Maria Nery, Melaragno, Maria Isabel, Bressan, Rodrigo Affonseca, Han, Sang Won, Abílio, Vanessa Costhek, and Belangero, Sintia Iole
- Published
- 2014
- Full Text
- View/download PDF
25. Changes in gene expression and methylation in the blood of patients with first-episode psychosis
- Author
-
Ota, Vanessa Kiyomi, Noto, Cristiano, Gadelha, Ary, Santoro, Marcos Leite, Spindola, Leticia Maria, Gouvea, Eduardo Sauerbronn, Stilhano, Roberta Sessa, Ortiz, Bruno Bertolucci, Silva, Patricia Natalia, Sato, João Ricardo, Han, Sang Won, Cordeiro, Quirino, Bressan, Rodrigo Affonseca, and Belangero, Sintia Iole
- Published
- 2014
- Full Text
- View/download PDF
26. Early life adversity, genomic plasticity, and psychopathology
- Author
-
Turecki, Gustavo, Ota, Vanessa Kiyomi, Belangero, Sintia Iole, Jackowski, Andrea, and Kaufman, Joan
- Published
- 2014
- Full Text
- View/download PDF
27. Evaluation of neurotransmitter receptor gene expression identifies GABA receptor changes: A follow-up study in antipsychotic-naïve patients with first-episode psychosis
- Author
-
Ota, Vanessa Kiyomi, Noto, Cristiano, Gadelha, Ary, Santoro, Marcos Leite, Ortiz, Bruno Bertolucci, Andrade, Elvis Henrique, Tasso, Brazilio Carvalho, Spindola, Leticia Maria Nery, Silva, Patricia Natalia, Abílio, Vanessa Costhek, Smith, Marília de Arruda Cardoso, Sato, João Ricardo, Brietzke, Elisa, Cordeiro, Quirino, Bressan, Rodrigo Affonseca, and Belangero, Sintia Iole
- Published
- 2014
- Full Text
- View/download PDF
28. Effect of antipsychotic drugs on gene expression in the prefrontal cortex and nucleus accumbens in the spontaneously hypertensive rat (SHR)
- Author
-
Santoro, Marcos Leite, Ota, Vanessa Kiyomi, Stilhano, Roberta Sessa, Silva, Patrícia Natália, Santos, Camila Maurício, Diana, Mariana Cepollaro, Gadelha, Ary, Bressan, Rodrigo Affonseca, Melaragno, Maria Isabel, Han, Sang Won, Abílio, Vanessa Costhek, and Belangero, Sintia Iole
- Published
- 2014
- Full Text
- View/download PDF
29. Depression, Cytokine, and Cytokine by Treatment Interactions Modulate Gene Expression in Antipsychotic Naïve First Episode Psychosis
- Author
-
Noto, Cristiano, Ota, Vanessa Kiyomi, Santoro, Marcos Leite, Gouvea, Eduardo Sauerbronn, Silva, Patricia Natalia, Spindola, Leticia Maria, Cordeiro, Quirino, Bressan, Rodrigo Affonseca, Gadelha, Ary, Brietzke, Elisa, Belangero, Sintia Iole, and Maes, Michael
- Published
- 2016
- Full Text
- View/download PDF
30. Shorter Telomeres Related to Posttraumatic Stress Disorder Re-experiencing Symptoms in Sexually Assaulted Civilian Women
- Author
-
Carvalho, Carolina Muniz, primary, Coimbra, Bruno Messina, additional, Xavier, Gabriela, additional, Bugiga, Amanda V. G., additional, Fonseca, Tamiris, additional, Olff, Miranda, additional, Polimanti, Renato, additional, Mello, Andrea Feijó, additional, Ota, Vanessa Kiyomi, additional, Mello, Marcelo Feijó, additional, and Belangero, Sintia Iole, additional
- Published
- 2022
- Full Text
- View/download PDF
31. Mapping genomic loci prioritises genes and implicates synaptic biology in schizophrenia
- Author
-
Trubetskoy, Vassily, Pardinas, Antonio, Qi, Ting, Panagiotaropoulou, Georgia, Awasthi, Swapnil, Bigdeli, Tim B., Bryois, Julien, Chen, Chia-Yen, Dennison, Charlotte A., Hall, Lynsey, Lam, Max, Watanabe, Kyoto, Frei, Oleksandr, Ge, Tian, Harwood, Janet C., Koopmans, Frank, Magnusson, Sigurdur, Richards, Alexander L., Sidorenko, Julia, Wu, Yang, Zeng, Jian, Grove, Jakob, Kim, Minsoo, Li, Zhiqiang, Voloudakis, Georgios, Zhang, Wen, Adams, Mark, Agartz, Ingrid, Atkinson, Elizabeth G., Agerbo, Esben, Al Eissa, Mariam, Albus, Margot, Alexander, Madeline, Alizadeh, Behrooz Z., Alptekin, Köksal, Als, Thomas D., Amin, Farooq, Arolt, Volker, Arrojo, Manuel, Athanasiu, Lavinia, Azevedo, Maria Helena, Bacanu, Silviu A., Bass, Nicholas J., Begemann, Martin, Belliveau, Richard A., Bene, Judit, Benyamin, Beben, Bergen, Sarah E., Blasi, Giuseppe, Bobes, Julio, Bonassi, Stefano, Braun, Alice, Affonseca Bressan, Rodrigo, Bromet, Evelyn J., Bruggeman, Richard, Buckley, Peter F., Buckner, Randy L., Bybjerg-Grauholm, Jonas, Cahn, Wiepke, Cairns, Murray J., Calkins, Monica E., Carr, Vaughan J., Castle, David, Catts, Stanley V., Chambert, Kimberley D., Chan, Raymond C. K., Chaumette, Boris, Cheng, Wei, Cheung, Eric F. C., Chong, Siow Ann, Cohen, David, Consoli, Angele, Cordeiro, Quirino, Costas, Javier, Curtis, Charles, Davidson, Michael, Davis, Kenneth L., De Haan, Lieuwe, Degenhardt, Franziska, DeLisi, Lynn E., Demontis, Ditte, Dickerson, Faith, Dikeos, Dimitris, Dinan, Timothy, Djurovic, Srdjan, Duan, Jubao, Ducci, Giuseppe, Dudbridge, Frank, Eriksson, Johan G., Fananas, Lourdes, Faraone, Stephen V., Fiorentino, Alessia, Forstner, Andreas, Frank, Josef, Freimer, Nelson B., Fromer, Menachem, Frustaci, Alessandra, Gadelha, Ary, Genovese, Giulio, Gershon, Elliot S., Giannitelli, Marianna, Giegling, Ina, Giusti-Rodríguez, Paola, Godard, Stephanie, Goldstein, Jacqueline I., González Peñas, Javier, González-Pinto, Ana, Gopa, Srihari, Gratten, Jacob, Green, Michael F., Greenwood, Tiffany A., Guillin, Olivier, Gülöksüz, Sinan, Gur, Raquel E., Gur, Ruben C., Gutiérrez, Blanca, Hahn, Eric, Hakonarson, Hakon, Haroutunian, Vahram, Hartmann, Annette M., Harvey, Carol, Hayward, Caroline, Henskens, Frans A., Herms, Stefan, Hoffmann, Per, Howrigan, Daniel P., Ikeda, Masashi, Iyegbe, Conrad, Joa, Inge, Julià, Antonio, Kähler, Anna K., Kam-Thong, Tony, Kamatani, Yoichiro, Karachanak-Yankova, Sena, Kebir, Oussama, Keller, Matthew C., Kelly, Brian J., Khrunin, Andrey, Kim, Sung-Wan, Klovins, Janis, Kondratiev, Nikolay, Konte, Bettina, Kraft, Julia, Kubo, Michiaki, Kučinskas, Vaidutis, Ausrele Kučinskiene, Zita, Kusumawardhani, Agung, Kuzelov a-Ptackova, Hana, Land, Stefano, Lazzeroni, Laura C., Lee, Phil H., Legge, Sophie E., Lehrer, Douglas S., Lencer, Rebecca, Lerer, Bernard, Li, Miaoxin, Lieberman, Jeffrey, Light, Gregory A., Limborska, Svetlana, Liu, Chih-Min, Lönnqvist, Jouko, Loughland, Carmel M., Lubiski, Jan, Luykx, Jurjen J., Lynham, Amy, Macel Jr., Milan, Mackinnon, Andrew, Magnusson, Patrik K. E., Maher, Brion S., Maier, Wolfgang, Malaspina, Dolores, Mallet, Jacques, Marder, Stephen R., Marsal, Sara, Martin, Alicia R., Martorell, Lourdes, Mattheisen, Manuel, McCarley, Robert W., McDonald, Colm, McGrath, John J., Medeiros, Helena, Meier, Sandra, Melegh, Bela, Melle, Ingrid, Mesholam-Gately, Raquelle I., Metspalu, Andres, Michie, Patricia T., Milani, Lili, Milanova, Vihara, Mitjans, Marina, Molden, Espen, Molina, Esther, Molto, María Dolores, Mondelli, Valeria, Moreno, Carmen, Morley, Christopher P., Muntané, Gerard, Murphy, Kieran C., Myin-Germeys, Inez, Nenadić, Igor, Nestadt, Gerald, Nikitina-Zake, Liene, Noto, Cristiano, Neuchterlein, Keith H., O'Brien, Niamh Louise, O'Neill, F. Anthony., Oh, Sang-Yun, Olincy, Ann, Ota, Vanessa Kiyomi, Pantelis, Christos, Papadimitrou, George N., Paredella, Mara, Paurio, Tiina, Pellegrino, Renata, Periyasamy, Sathish, Perkins, Diana O., Pfuhlmann, Bruno, Pietilainen, Olli, Pimm, Jonathan, Porteous, David, Powell, John, Quattrone, Diego, Quested, Digby, Radant, Allen D., Rampino, Antonio, Rapaport, Mark H., Rautanen, Anna, Reichenberg, Abraham, Roe, Cheryl, Roffman, Joshua L., Roth, Julian, Rothermundt, Matthias, Rutten, Bart P. F., Saker-Delye, Safaa, Salomaa, Veiko, Sanjuan, Julio, Santoro, Marcos Leite, Savitz, Adam, Schall, Ulrich, Scott, Rodney J., Seidman, Larry J., Sharp, Sally Isabel, Shi, Jianxin, Sigurdsson, Engilbert, Sim, Kang, Skarabis, Nora, Slominsky, Petr, So, Hon-Cheong, Sobell, Janet L., Soderman, Erik, Stain, Helen J., Steen, Nils Eiel, Steixner-Kumar, Agnes, Stogmann, Elisabeth, Stone, William S., Straub, Richard E., Streit, Fabian, Stregman, Eric, Stroup, T. Scott, Subramaniam, Mythily, Sugar, Catherine A., Suvisaari, Jaana, Svrakic, Dragan M., Swerdlow, Neal R., Szatkiewicz, Jin P., Ta, Thi Minh Tam, and Takahashi, Atsushi
- Abstract
Schizophrenia has a heritability of 60–80%1, much of which is attributable to common risk alleles. Here, in a two-stage genome-wide association study of up to 76,755 individuals with schizophrenia and 243,649 control individuals, we report common variant associations at 287 distinct genomic loci. Associations were concentrated in genes that are expressed in excitatory and inhibitory neurons of the central nervous system, but not in other tissues or cell types. Using fine-mapping and functional genomic data, we identify 120 genes (106 protein-coding) that are likely to underpin associations at some of these loci, including 16 genes with credible causal non-synonymous or untranslated region variation. We also implicate fundamental processes related to neuronal function, including synaptic organization, differentiation and transmission. Fine-mapped candidates were enriched for genes associated with rare disruptive coding variants in people with schizophrenia, including the glutamate receptor subunit GRIN2A and transcription factor SP4, and were also enriched for genes implicated by such variants in neurodevelopmental disorders. We identify biological processes relevant to schizophrenia pathophysiology; show convergence of common and rare variant associations in schizophrenia and neurodevelopmental disorders; and provide a resource of prioritized genes and variants to advance mechanistic studies.
- Published
- 2022
32. Mapping genomic loci implicates genes and synaptic biology in schizophrenia
- Author
-
Medical Research Council (UK), National Natural Science Foundation of China, Royal Society (UK), Chinese Academy of Sciences, Shanghai Science and Technology Committee, Research Council of Norway, European Commission, Fundação de Amparo à Pesquisa do Estado de São Paulo, Ministerio de Ciencia e Innovación (España), Instituto de Salud Carlos III, Comunidad de Madrid, Fundación Alicia Koplowitz, Fundación Alonso Lozano, Mental Health Research UK, Wellcome Trust, Brain and Behavior Research Foundation, NIHR Biomedical Research Centre (UK), University College London, Generalitat Valenciana, Trubetskoy, Vassily, Pardiñas, Antonio F., Qi, Ting, Panagiotaropoulou, Georgia, Awasthi, Swapnil, Bigdeli, Tim B., Bryois, Julien, Chen, Chia-Yen, Dennison, Charlotte A., Hall, Lynsey S., Lam, Max, Curtis, Charles, Nikitina-Zake, Liene, Davidson, Michael, Joa, Inge, Davis, Kenneth L., Yolken, Robert, Murray, Robin M., de Haan, Lieuwe, Legge, Sophie E., Serretti, Alessandro, van Os, Jim, Smoller, Jordan W., Agartz, Ingrid, Alizadeh, Behrooz Z., Degenhardt, Franziska, DeLisi, Lynn E., Demontis, Ditte, Dickerson, Faith, Zai, Clement C., Dikeos, Dimitris, Dinan, Timothy, Henskens, Frans A., Vaaler, Arne, Noto, Cristiano, Nimgaonkar, Vishwajit, Rautanen, Anna, Lehrer, Douglas S., Djurovic, Srdjan, Duan, Jubao, Julià, Antonio, Stahl, Eli A., Zhou, Wei, Vawter, Marquis P., Toncheva, Draga, Webb, Bradley T., Ducci, Giuseppe, Dudbridge, Frank, Eriksson, Johan G., Fañanas Saura, Lourdes, Goldstein, Jacqueline I., Faraone, Stephen V., Lencer, Rebecca, Moreno, Carmen, Bacanu, Silviu A., Fiorentino, Alessia, Calkins, Monica E., Mitjans, Marina, Forstner, Andreas, Nuechterlein, Keith H., Frank, Josef, Tsuang, Debby W., Freimer, Nelson B., Tooney, Paul A., Belangero, Sintia Iole, Weinberger, Daniel R., Fromer, Menachem, Ge,Tian, Adolfsson, Rolf, Hakonarson, Hakon, Zhu, Feng, Frustaci, Alessandra, Nöthen, Markus M., Gadelha, Ary, Genovese, Giulio, Gershon, Elliot S., Quattrone, Diego, Kähler, Anna K., Kam-Thong, Tony, van Amelsvoort, Therese, Vilella, Elisabet, Molden, Espen, O'Brien, Niamh Louise, Zimprich, Fritz, Kamatani, Yoichiro, Braun, Alice, Melegh, Bela, Pirinen, Matti, Karachanak-Yankova, Sena, Ophoff, Roel A., Kebir, Oussama, Lerer, Bernard, Nordentoft, Merete, Fanous, Ayman H., Reichenberg, Abraham, Li, Miaoxin, Periyasamy, Sathish, Lieberman, Jeffrey, Werge, Thomas, Light, Gregory A., Limborska, Svetlana, Tosato, Sarah, Liu, Chih-Min, Olincy, Ann, Magnusson, Sigurdur, Gareeva, Anna, Bressan, Rodrigo Affonseca, Lönnqvist, Jouko, Roe, Cheryl, Cheng, Wei, Athanasiu, Lavinia, Gutiérrez, Blanca, Harvey, Carol, Loughland, Carmel M., Lubinski, Jan, Luykx, Jurjen J., Lynham, Amy, Gawlik, Micha, Macek, Milan, Mackinnon, Andrew, Buxbaum, Joseph D., Tura, Gian Battista, Bromet, Evelyn J., Atbaşoğlu, Eşref Cem, Roffman, Joshua L., Magnusson, Patrik K. E., Maher, Brion S., Ota, Vanessa Kiyomi, Paciga, Sara A., Gejman, Pablo V., Arango, Celso, Forti, Marta Di, Maier, Wolfgang, Richards, Alexander L., Malaspina, Dolores, Mallet, Jacques, Metspalu, Andres, Marder, Stephen R., Li, Zhiqiang, Takahashi, Atsushi, Marsal, Sara, Kučinskiene, Zita Ausrele, Suvisaari, Jaana, Martin, Alicia R., Turetsky, Bruce I., Martorell, Lourdes, Palotie, Aarno, Mattheisen, Manuel, Baune, Bernhard T., Saka, Meram C., McCarley, Robert W., Giusti-Rodríguez, Paola, Riley, Brien P., Murphy, Kieran C., Gill, Michael, McDonald, Colm, Bruggeman, Richard, McGrath, John J., Sidorenko, Julia, Medeiros, Helena, Pantelis, Christos, Grove, Jakob, Campion, Dominique, Pato, Carlos N., Svrakic, Dragan M., Üçok, Alp, Glatt, Stephen J., Papadimitriou, George N., Khrunin, Andrey, Straub, Richard E., Parellada, Mara, Buckley, Peter F., Paunio, Tiina, Roth, Julian, Morgan, Vera A., Wildenauer, Dieter B., Ayub, Muhammad, Rothermundt, Matthias, Weiser, Mark, Rutten, Bart P. F., Saker-Delye, Safaa, Salomaa, Veikko, Børglum, Anders D., Sanjuán, Julio, van Winkel, Ruud, González Peñas, Javier, Yu, Xin, Kim, Sung-Wan, Santoro, Marcos Leite, Benner, Christian, Ikeda, Masashi, Morley, Christopher P., Zeng, Jian, Savitz, Adam, Schall, Ulrich, Scott, Rodney J., Voloudakis, Georgios, Yue, Weihua, Seidman, Larry J., Sharp, Sally Isabel, Alptekin, Köksal, Klovins, Janis, Amin, Farooq, Bertolino, Alessandro, Shi, Jianxin, Siever, Larry J., Atkinson, Elizabeth G., Buckner, Randy L., Holmans, Peter A., Rivera, Margarita, Sigurdsson, Engilbert, González-Pinto, Ana, Sim, Kang, Skarabis, Nora, Stroup, T Scott, Slominsky, Petr, Guillin, Olivier, Wang, Shi-Heng, So, Hon-Cheong, Quested, Digby, Sobell, Janet L., Braff, David, Zhang, Wen, Bybjerg-Grauholm, Jonas, Söderman, Erik, Rujescu, Dan, Chambert, Kimberley D., Stain, Helen J., Melle, Ingrid, Carr, Vaughan J, Pocklington, Andrew J., Steen, Nils Eiel, Harwood, Janet, Steixner-Kumar, Agnes A., Gopal, Srihari, Stögmann, Elisabeth, Veijola, Juha, Watanabe, Kyoko, Sham, Pak C., Cahn, Wiepke, Bramon, Elvira, Roussos, Panos, Waddington, John, Perkins, Diana O., Pato, Michele T., Walter, Henrik, Kondratiev, Nikolay, Waterreus, Anna, Al Eissa, Mariam, Bobes, Julio, Golimbet, Vera, Black, Donald W., Als, Thomas D., Bray, Nicholas J., Breen, Gerome, Buccola, Nancy G., Sanders, Alan R., Byerley, William F., Cervilla, Jorge A., Michie, Patricia T., Pfuhlmann, Bruno, Chen, Wei J., Hong, Kyung Sue, O'Neill, F Anthony, Terao, Chikashi, Green, Michael F., Cloninger, C. Robert, Crespo-Facorro, Benedicto, Donohoe, Gary, Gülöksüz, Sinan, Freedman, Robert, Albus, Margot, Hayward, Caroline, Pietiläinen, Olli, Herms, Stefan, Hultman, Christina M., Galletly, Cherrie, Gandal, Michael J., Hahn, Eric, Konte, Bettina, Castle, David, Gennarelli, Massimo, Milani, Lili, Hougaard, David M., Hwu, Hai-Gwo, Pulver, Ann E., Jablensky, Assen V., Molina, Esther, Qin, Shengying, McCarroll, Steven A., Moran, Jennifer L., Azevedo, Maria Helena, Gur, Rachel E., Kraft, Julia, Mors, Ole, Catts, Stanley V., Lazzeroni, Laura C., Mortensen, Preben B., Streit, Fabian, Kusumawardhani, Agung, Alexander, Madeline, Godard, Stephanie, Müller-Myhsok, Bertram, Milanova, Vihra, Neil, Amanda L., Cichon, Sven, Giannitelli, Marianna, Cheung, Eric F. C., Kubo, Michiaki, Schwab, Sibylle G., Collier, David A., Williams, Nigel M., Morris, Derek W., Corvin, Aiden, Pimm, Jonathan, Curtis, David, Haroutunian, Vahram, Keller, Matthew C., Vassos, Evangelos, Hyman, Steven E., Iwata, Nakao, Jönsson, Erik G., Kahn, René S., Chan, Raymond C. K., Kennedy, James L., Shi, Yongyong, Adams, Mark, Witt, Stephanie H., Khusnutdinova, Elza, Verhage, Matthijs, Xu, Shuhua, Wu, Yang, Kirov, George, Arolt, Volker, Knowles, James A., Moltó, Maria Dolores, Krebs, Marie-Odile, Hartmann, Annette M., Nestadt, Gerald, Wormley, Brandon K., Bass, Nicholas J., Laurent-Levinson, Claudine, Lee, Jimmy, Muntané, Gerard, Porteous, David, Kuzelova-Ptackova, Hana, Lencz, Todd, Subramaniam, Mythily, Levinson, Douglas F., Li, Qingqin S., Liu, Jianjun, Swerdlow, Neal R., Cairns, Murray J., Malhotra, Anil K., Malhotra, Dheeraj, Iyegbe, Conrad, Mondelli, Valeria, Kim, Minsoo, Arrojo, Manuel, Landi, Stefano, McIntosh, Andrew M., Petryshen, Tracey L., Radant, Allen D., Frei, Oleksandr, Mesholam-Gately, Raquelle I., McQuillin, Andrew, Sugar, Catherine A., Menezes, Paulo Rossi, St Clair, David, Meier, Sandra, Powell, John, Chaumette, Boris, Stefansson, Hreinn, Domenici, Enrico, Bonassi, Stefano, Stefánsson, Kári, Wu, Jing Qin, Tsuang, Ming T., Myin-Germeys, Inez, Pellegrino, Renata, Visscher, Peter M., Yang, Jian, Posthuma, Danielle, Andreassen, Ole A., Koopmans, Frank, Kendler, Kenneth S., Chong, Siow Ann, Gur, Ruben C., Ehrenreich, Hannelore, Owen, Michael J., Rietschel, Marcella, Gratten, Jacob, Wray, Naomi R., Hoffmann, Per, Daly, Mark J., Szatkiewicz, Jin P., Huang, Hailiang, Nenadić, Igor, Torretta, Silvia, Escott-Price, Valentina, Neale, Benjamin M., Begemann, Martin, Thibaut, Florence, Agerbo, Esben, Rampino, Antonio, Sullivan, Patrick F., Schulze, Thomas G., Ripke, Stephan, Walters, James T. R., O'Donovan, Michael C., Kučinskas, Vaidutis, Belliveau, Richard A., Bene, Judit, Oh, Sang-Yun, Ta, Thi Minh Tam, Greenwood, Tiffany A., Howrigan, Daniel P., Rapaport, Mark H., Benyamin, Beben, Mowry, Bryan J., Giegling, Ina, Strengman, Eric, Bergen, Sarah E., Silverman, Jeremy M., Blasi, Giuseppe, Cohen, David, Stone, William S., Xu, Zhida, Lee, Phil H., Consoli, Angèle, Kelly, Brian J.., Cordeiro, Quirino, Esko, Tõnu, Costas, Javier, Medical Research Council (UK), National Natural Science Foundation of China, Royal Society (UK), Chinese Academy of Sciences, Shanghai Science and Technology Committee, Research Council of Norway, European Commission, Fundação de Amparo à Pesquisa do Estado de São Paulo, Ministerio de Ciencia e Innovación (España), Instituto de Salud Carlos III, Comunidad de Madrid, Fundación Alicia Koplowitz, Fundación Alonso Lozano, Mental Health Research UK, Wellcome Trust, Brain and Behavior Research Foundation, NIHR Biomedical Research Centre (UK), University College London, Generalitat Valenciana, Trubetskoy, Vassily, Pardiñas, Antonio F., Qi, Ting, Panagiotaropoulou, Georgia, Awasthi, Swapnil, Bigdeli, Tim B., Bryois, Julien, Chen, Chia-Yen, Dennison, Charlotte A., Hall, Lynsey S., Lam, Max, Curtis, Charles, Nikitina-Zake, Liene, Davidson, Michael, Joa, Inge, Davis, Kenneth L., Yolken, Robert, Murray, Robin M., de Haan, Lieuwe, Legge, Sophie E., Serretti, Alessandro, van Os, Jim, Smoller, Jordan W., Agartz, Ingrid, Alizadeh, Behrooz Z., Degenhardt, Franziska, DeLisi, Lynn E., Demontis, Ditte, Dickerson, Faith, Zai, Clement C., Dikeos, Dimitris, Dinan, Timothy, Henskens, Frans A., Vaaler, Arne, Noto, Cristiano, Nimgaonkar, Vishwajit, Rautanen, Anna, Lehrer, Douglas S., Djurovic, Srdjan, Duan, Jubao, Julià, Antonio, Stahl, Eli A., Zhou, Wei, Vawter, Marquis P., Toncheva, Draga, Webb, Bradley T., Ducci, Giuseppe, Dudbridge, Frank, Eriksson, Johan G., Fañanas Saura, Lourdes, Goldstein, Jacqueline I., Faraone, Stephen V., Lencer, Rebecca, Moreno, Carmen, Bacanu, Silviu A., Fiorentino, Alessia, Calkins, Monica E., Mitjans, Marina, Forstner, Andreas, Nuechterlein, Keith H., Frank, Josef, Tsuang, Debby W., Freimer, Nelson B., Tooney, Paul A., Belangero, Sintia Iole, Weinberger, Daniel R., Fromer, Menachem, Ge,Tian, Adolfsson, Rolf, Hakonarson, Hakon, Zhu, Feng, Frustaci, Alessandra, Nöthen, Markus M., Gadelha, Ary, Genovese, Giulio, Gershon, Elliot S., Quattrone, Diego, Kähler, Anna K., Kam-Thong, Tony, van Amelsvoort, Therese, Vilella, Elisabet, Molden, Espen, O'Brien, Niamh Louise, Zimprich, Fritz, Kamatani, Yoichiro, Braun, Alice, Melegh, Bela, Pirinen, Matti, Karachanak-Yankova, Sena, Ophoff, Roel A., Kebir, Oussama, Lerer, Bernard, Nordentoft, Merete, Fanous, Ayman H., Reichenberg, Abraham, Li, Miaoxin, Periyasamy, Sathish, Lieberman, Jeffrey, Werge, Thomas, Light, Gregory A., Limborska, Svetlana, Tosato, Sarah, Liu, Chih-Min, Olincy, Ann, Magnusson, Sigurdur, Gareeva, Anna, Bressan, Rodrigo Affonseca, Lönnqvist, Jouko, Roe, Cheryl, Cheng, Wei, Athanasiu, Lavinia, Gutiérrez, Blanca, Harvey, Carol, Loughland, Carmel M., Lubinski, Jan, Luykx, Jurjen J., Lynham, Amy, Gawlik, Micha, Macek, Milan, Mackinnon, Andrew, Buxbaum, Joseph D., Tura, Gian Battista, Bromet, Evelyn J., Atbaşoğlu, Eşref Cem, Roffman, Joshua L., Magnusson, Patrik K. E., Maher, Brion S., Ota, Vanessa Kiyomi, Paciga, Sara A., Gejman, Pablo V., Arango, Celso, Forti, Marta Di, Maier, Wolfgang, Richards, Alexander L., Malaspina, Dolores, Mallet, Jacques, Metspalu, Andres, Marder, Stephen R., Li, Zhiqiang, Takahashi, Atsushi, Marsal, Sara, Kučinskiene, Zita Ausrele, Suvisaari, Jaana, Martin, Alicia R., Turetsky, Bruce I., Martorell, Lourdes, Palotie, Aarno, Mattheisen, Manuel, Baune, Bernhard T., Saka, Meram C., McCarley, Robert W., Giusti-Rodríguez, Paola, Riley, Brien P., Murphy, Kieran C., Gill, Michael, McDonald, Colm, Bruggeman, Richard, McGrath, John J., Sidorenko, Julia, Medeiros, Helena, Pantelis, Christos, Grove, Jakob, Campion, Dominique, Pato, Carlos N., Svrakic, Dragan M., Üçok, Alp, Glatt, Stephen J., Papadimitriou, George N., Khrunin, Andrey, Straub, Richard E., Parellada, Mara, Buckley, Peter F., Paunio, Tiina, Roth, Julian, Morgan, Vera A., Wildenauer, Dieter B., Ayub, Muhammad, Rothermundt, Matthias, Weiser, Mark, Rutten, Bart P. F., Saker-Delye, Safaa, Salomaa, Veikko, Børglum, Anders D., Sanjuán, Julio, van Winkel, Ruud, González Peñas, Javier, Yu, Xin, Kim, Sung-Wan, Santoro, Marcos Leite, Benner, Christian, Ikeda, Masashi, Morley, Christopher P., Zeng, Jian, Savitz, Adam, Schall, Ulrich, Scott, Rodney J., Voloudakis, Georgios, Yue, Weihua, Seidman, Larry J., Sharp, Sally Isabel, Alptekin, Köksal, Klovins, Janis, Amin, Farooq, Bertolino, Alessandro, Shi, Jianxin, Siever, Larry J., Atkinson, Elizabeth G., Buckner, Randy L., Holmans, Peter A., Rivera, Margarita, Sigurdsson, Engilbert, González-Pinto, Ana, Sim, Kang, Skarabis, Nora, Stroup, T Scott, Slominsky, Petr, Guillin, Olivier, Wang, Shi-Heng, So, Hon-Cheong, Quested, Digby, Sobell, Janet L., Braff, David, Zhang, Wen, Bybjerg-Grauholm, Jonas, Söderman, Erik, Rujescu, Dan, Chambert, Kimberley D., Stain, Helen J., Melle, Ingrid, Carr, Vaughan J, Pocklington, Andrew J., Steen, Nils Eiel, Harwood, Janet, Steixner-Kumar, Agnes A., Gopal, Srihari, Stögmann, Elisabeth, Veijola, Juha, Watanabe, Kyoko, Sham, Pak C., Cahn, Wiepke, Bramon, Elvira, Roussos, Panos, Waddington, John, Perkins, Diana O., Pato, Michele T., Walter, Henrik, Kondratiev, Nikolay, Waterreus, Anna, Al Eissa, Mariam, Bobes, Julio, Golimbet, Vera, Black, Donald W., Als, Thomas D., Bray, Nicholas J., Breen, Gerome, Buccola, Nancy G., Sanders, Alan R., Byerley, William F., Cervilla, Jorge A., Michie, Patricia T., Pfuhlmann, Bruno, Chen, Wei J., Hong, Kyung Sue, O'Neill, F Anthony, Terao, Chikashi, Green, Michael F., Cloninger, C. Robert, Crespo-Facorro, Benedicto, Donohoe, Gary, Gülöksüz, Sinan, Freedman, Robert, Albus, Margot, Hayward, Caroline, Pietiläinen, Olli, Herms, Stefan, Hultman, Christina M., Galletly, Cherrie, Gandal, Michael J., Hahn, Eric, Konte, Bettina, Castle, David, Gennarelli, Massimo, Milani, Lili, Hougaard, David M., Hwu, Hai-Gwo, Pulver, Ann E., Jablensky, Assen V., Molina, Esther, Qin, Shengying, McCarroll, Steven A., Moran, Jennifer L., Azevedo, Maria Helena, Gur, Rachel E., Kraft, Julia, Mors, Ole, Catts, Stanley V., Lazzeroni, Laura C., Mortensen, Preben B., Streit, Fabian, Kusumawardhani, Agung, Alexander, Madeline, Godard, Stephanie, Müller-Myhsok, Bertram, Milanova, Vihra, Neil, Amanda L., Cichon, Sven, Giannitelli, Marianna, Cheung, Eric F. C., Kubo, Michiaki, Schwab, Sibylle G., Collier, David A., Williams, Nigel M., Morris, Derek W., Corvin, Aiden, Pimm, Jonathan, Curtis, David, Haroutunian, Vahram, Keller, Matthew C., Vassos, Evangelos, Hyman, Steven E., Iwata, Nakao, Jönsson, Erik G., Kahn, René S., Chan, Raymond C. K., Kennedy, James L., Shi, Yongyong, Adams, Mark, Witt, Stephanie H., Khusnutdinova, Elza, Verhage, Matthijs, Xu, Shuhua, Wu, Yang, Kirov, George, Arolt, Volker, Knowles, James A., Moltó, Maria Dolores, Krebs, Marie-Odile, Hartmann, Annette M., Nestadt, Gerald, Wormley, Brandon K., Bass, Nicholas J., Laurent-Levinson, Claudine, Lee, Jimmy, Muntané, Gerard, Porteous, David, Kuzelova-Ptackova, Hana, Lencz, Todd, Subramaniam, Mythily, Levinson, Douglas F., Li, Qingqin S., Liu, Jianjun, Swerdlow, Neal R., Cairns, Murray J., Malhotra, Anil K., Malhotra, Dheeraj, Iyegbe, Conrad, Mondelli, Valeria, Kim, Minsoo, Arrojo, Manuel, Landi, Stefano, McIntosh, Andrew M., Petryshen, Tracey L., Radant, Allen D., Frei, Oleksandr, Mesholam-Gately, Raquelle I., McQuillin, Andrew, Sugar, Catherine A., Menezes, Paulo Rossi, St Clair, David, Meier, Sandra, Powell, John, Chaumette, Boris, Stefansson, Hreinn, Domenici, Enrico, Bonassi, Stefano, Stefánsson, Kári, Wu, Jing Qin, Tsuang, Ming T., Myin-Germeys, Inez, Pellegrino, Renata, Visscher, Peter M., Yang, Jian, Posthuma, Danielle, Andreassen, Ole A., Koopmans, Frank, Kendler, Kenneth S., Chong, Siow Ann, Gur, Ruben C., Ehrenreich, Hannelore, Owen, Michael J., Rietschel, Marcella, Gratten, Jacob, Wray, Naomi R., Hoffmann, Per, Daly, Mark J., Szatkiewicz, Jin P., Huang, Hailiang, Nenadić, Igor, Torretta, Silvia, Escott-Price, Valentina, Neale, Benjamin M., Begemann, Martin, Thibaut, Florence, Agerbo, Esben, Rampino, Antonio, Sullivan, Patrick F., Schulze, Thomas G., Ripke, Stephan, Walters, James T. R., O'Donovan, Michael C., Kučinskas, Vaidutis, Belliveau, Richard A., Bene, Judit, Oh, Sang-Yun, Ta, Thi Minh Tam, Greenwood, Tiffany A., Howrigan, Daniel P., Rapaport, Mark H., Benyamin, Beben, Mowry, Bryan J., Giegling, Ina, Strengman, Eric, Bergen, Sarah E., Silverman, Jeremy M., Blasi, Giuseppe, Cohen, David, Stone, William S., Xu, Zhida, Lee, Phil H., Consoli, Angèle, Kelly, Brian J.., Cordeiro, Quirino, Esko, Tõnu, and Costas, Javier
- Abstract
Schizophrenia has a heritability of 60-80%1, much of which is attributable to common risk alleles. Here, in a two-stage genome-wide association study of up to 76,755 individuals with schizophrenia and 243,649 control individuals, we report common variant associations at 287 distinct genomic loci. Associations were concentrated in genes that are expressed in excitatory and inhibitory neurons of the central nervous system, but not in other tissues or cell types. Using fine-mapping and functional genomic data, we identify 120 genes (106 protein-coding) that are likely to underpin associations at some of these loci, including 16 genes with credible causal non-synonymous or untranslated region variation. We also implicate fundamental processes related to neuronal function, including synaptic organization, differentiation and transmission. Fine-mapped candidates were enriched for genes associated with rare disruptive coding variants in people with schizophrenia, including the glutamate receptor subunit GRIN2A and transcription factor SP4, and were also enriched for genes implicated by such variants in neurodevelopmental disorders. We identify biological processes relevant to schizophrenia pathophysiology; show convergence of common and rare variant associations in schizophrenia and neurodevelopmental disorders; and provide a resource of prioritized genes and variants to advance mechanistic studies.
- Published
- 2022
33. Obsessive-compulsive symptoms, polygenic risk score, and thalamic development in children from the Brazilian High-Risk Cohort for Mental Conditions (BHRCS)
- Author
-
Salto, Ana Beatriz Ravagnani, Santoro, Marcos Leite, Hoexter, Marcelo Queiroz, Jackowski, Andrea Parolin, Pan, Pedro Mario, Rosário, Maria Conceição do, Belangero, Síntia Iole Nogueira, Alvarenga, Pedro Gomes de, Doretto, Victoria Fogaça, Fumo, Afonso Mazine Tiago, Batistuzzo, Marcelo Camargo, Barros, Pedro Macul Ferreira de, Timpano, Kiara R., Ota, Vanessa Kiyomi Arashiro, Rohde, Luis Augusto Paim, Miguel, Eurípedes Constantino, Leckman, James F., and Zugman, André
- Subjects
Transtorno obsessivo-compulsivo ,Obsessive-compulsive symptoms ,Magnetic resonance imaging ,Thalamus ,Polygenic risk score ,Imageamento por ressonância magnética ,Obsessive-compulsive disorder ,Neuroimaging ,Neuroimagem ,OCD-PRS ,Tálamo ,Herança multifatorial ,MRI - Abstract
Background: Thalamic volume measures have been linked to obsessive-compulsive disorder (OCD) in children and adolescents. However, it is unclear if alterations in thalamic volumes occur before or after symptom onset and if there is a relation to the presence of sub-clinical obsessive-compulsive symptoms (OCS). Here, we explore the relationship between OCS and the rate of thalamic volume change in a cohort of children and youth at high risk to develop a mental disorder. A secondary aim was to determine if there is a relationship between OCS and the individual’s OCD polygenic risk score (OCD-PRS) and between the rate of thalamic volume change and the OCD-PRS. Methods: The sample included 378 children enrolled in the longitudinal Brazilian High-Risk Cohort for Mental Conditions. Participants were assessed for OCS and the symmetrized percent change (SPC) of thalamic volume across two time-points separated by 3 years, along with the OCD-PRS. Zero-altered negative binomial models were used to analyze the relationship between OCS and thalamic SPC. Multiple linear regressions were used to examine the relationship between thalamic SPC and OCD-PRS. Results: A significant relationship between OCS and the right thalamus SPC (p = 0.042) was found. There was no significant relationship between changes in thalamic volume SPC and OCD-PRS. Conclusions: The findings suggest that changes in the right thalamic volume over the course of 3 years in children may be associated to OCS. Future studies are needed to confirm these results and further characterize the specific nature of OCS symptoms associated with thalamic volumes.
- Published
- 2021
34. APOA1/A5 Variants and Haplotypes as a Risk Factor for Obesity and Better Lipid Profiles in a Brazilian Elderly Cohort
- Author
-
Chen, Elizabeth Suchi, Furuya, Tatiane Katsue, Mazzotti, Diego Robles, Ota, Vanessa Kiyomi, Cendoroglo, Maysa Seabra, Ramos, Luiz Roberto, Araujo, Lara Quirino, Burbano, Rommel Rodriguez, and de Arruda Cardoso Smith, Marília
- Published
- 2010
- Full Text
- View/download PDF
35. A Systematic Review of LINE-1 Methylation Profile in Psychiatric Disorders
- Author
-
Alves, Vitória Rodrigues Guimarães, Micali, Danilo, Ota, Vanessa Kiyomi, Bugiga, Amanda Victória Gomes, Muniz Carvalho, Carolina, and Belangero, Sintia Iole
- Abstract
Introduction:Long interspersed nuclear elements (LINEs) are endogenous retrotransposable elements. A few studies have linked the methylation pattern of LINE-1 to different mental disorders (e.g., post-traumatic stress disorder [PTSD], autism spectrum disorder [ASD], panic disorder [PD]). We sought to unify the existing knowledge in the field and provide a better understanding of the association between mental disorders and LINE-1 methylation. Methods:A systematic review was executed with 12 eligible articles according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. Results:For psychotic disorders, PTSD, ASD, and PD, lower LINE-1 methylation levels were detected, whereas for mood disorders, the findings are controversial. The studies were conducted with subjects aged 18–80 years. Peripheral blood samples were utilized in 7/12 articles. Conclusion:Although most studies have shown that LINE-1 hypomethylation was associated with mental disorders, there were still some divergences (i.e., hypermethylation associated with mental disorders). These studies suggest that LINE-1 methylation may be an important factor related to the development of mental disorders and highlight the need to better comprehend the biological mechanisms underlying the role of LINE-1 in mental disorders pathophysiology.
- Published
- 2022
- Full Text
- View/download PDF
36. Gene expression changes associated with trajectories of psychopathology in a longitudinal cohort of children and adolescents
- Author
-
Ota, Vanessa Kiyomi Arashiro, Schafer, Julia Luiza, Rohde, Luis Augusto Paim, Salum Junior, Giovanni Abrahão, and Belangero, Síntia Iole Nogueira
- Subjects
Criança ,Expressão gênica ,Adolescente ,Psicopatologia - Abstract
We aimed to identify blood gene expression patterns associated to psychopathological trajectories retrieved from a large community, focusing on the emergence and remission of general psychiatric symptoms. Hundred and three individuals from the Brazilian High-Risk Cohort Study (BHRCS) for mental disorders were classified in four groups according to Child Behavior Checklist (CBCL) total score at the baseline (w0) and after 3 years (w1): low–high (L–H) (N = 27), high–low (H–L) (N = 12), high–high (H–H) (N = 34) and low–low (L–L) groups (N = 30). Blood gene expression profile was measured using Illumina HT-12 Beadchips, and paired analyses comparing w0 and w1 were performed for each group. Results: 98 transcripts were differentially expressed comparing w0 and w1 in the L-H, 33 in the H–L, 177 in the H–H and 273 in the L–L. Of these, 66 transcripts were differentially expressed exclusively in the L–H; and 6 only in the H–L. Cross-Lagged Panel Models analyses revealed that RPRD2 gene expression at w1 might be influenced by the CBCL score at w0. Moreover, COX5B, SEC62, and NDUFA2 were validated with another technique and were also differentially regulated in postmortem brain of subjects with mental disorders, indicating that they might be important not only to specific disorders, but also to general psychopathology and symptoms trajectories. Whereas genes related to metabolic pathways seem to be associated with the emergence of psychiatric symptoms, mitochondrial inner membrane genes might be important over the course of normal development. These results suggest that changes in gene expression can be detected in blood in different psychopathological trajectories.
- Published
- 2020
37. APOA4 Polymorphism as a Risk Factor for Unfavorable Lipid Serum Profile and Depression: A Cross-Sectional Study
- Author
-
Ota, Vanessa Kiyomi, Chen, Elizabeth Suchi, Ejchel, Tatiana Flank, Furuya, Tatiane Katsue, Mazzotti, Diego Robles, Cendoroglo, Maysa Seabra, Ramos, Luiz Roberto, Araujo, Lara Quirino, Burbano, Rommel Rodriguez, and Smith, Marília de Arruda Cardoso
- Published
- 2011
- Full Text
- View/download PDF
38. DGCR2 influences cortical thickness through a mechanism independent of schizophrenia pathogenesis
- Author
-
Belangero, Sintia Iole, Ota, Vanessa Kiyomi, Gadelha, Ary, Berberian, Arthur Almeida, Assunção-Leme, Idaiane Batista de, Noto, Cristiano, Christofolini, Denise Maria, Bellucco, Fernanda Teixeira, Santoro, Marcos Leite, Mazzotti, Diego Robles, Zugman, André, Melaragno, Maria Isabel, Smith, Marilia Arruda Cardoso, Pellegrino, Renata, Hakonarson, Hakon, Cordeiro, Quirino, Moretti, Patricia Natalia, Bressan, Rodrigo Affonseca, Mari, Jair de Jesus, and Jackowski, Andrea Parolin
- Published
- 2019
- Full Text
- View/download PDF
39. Is treatment-resistant schizophrenia associated with distinct neurobiological callosal connectivity abnormalities?
- Author
-
Assunção-Leme, Idaiane Batista, primary, Zugman, André, additional, de Moura, Luciana Monteiro, additional, Sato, João Ricardo, additional, Higuchi, Cinthia, additional, Ortiz, Bruno Bertolucci, additional, Noto, Cristiano, additional, Ota, Vanessa Kiyomi, additional, Belangero, Sintia Iole, additional, Bressan, Rodrigo A., additional, Crossley, Nicolas A., additional, Jackowski, Andrea P., additional, and Gadelha, Ary, additional
- Published
- 2020
- Full Text
- View/download PDF
40. LINE-1 hypomethylation is associated with poor risperidone response in a first episode of psychosis cohort
- Author
-
Marques, Diogo Ferri, primary, Ota, Vanessa Kiyomi, additional, Santoro, Marcos Leite, additional, Talarico, Fernanda, additional, Costa, Giovany Oliveira, additional, Spindola, Leticia Maria, additional, Cogo-Moreira, Hugo, additional, Carvalho, Carolina Muniz, additional, Xavier, Gabriela, additional, Cavalcante, Daniel Azevedo, additional, Gadelha, Ary, additional, Noto, Cristiano, additional, Cordeiro, Quirino, additional, Bressan, Rodrigo Affonseca, additional, Moretti, Patricia Natalia, additional, and Belangero, Sintia Iole, additional
- Published
- 2020
- Full Text
- View/download PDF
41. Is treatment-resistant schizophrenia associated with distinct neurobiological callosal connectivity abnormalities?
- Author
-
Assunção-Leme, Idaiane Batista, Zugman, André, de Moura, Luciana Monteiro, Sato, João Ricardo, Higuchi, Cinthia, Ortiz, Bruno Bertolucci, Noto, Cristiano, Ota, Vanessa Kiyomi, Belangero, Sintia Iole, Bressan, Rodrigo A., Crossley, Nicolas A., Jackowski, Andrea P., and Gadelha, Ary
- Abstract
AbstractBackgroundResistance to antipsychotic treatment affects up to 30% of patients with schizophrenia. Although the time course of development of treatment-resistant schizophrenia (TRS) varies from patient to patient, the reasons for these variations remain unknown. Growing evidence suggests brain dysconnectivity as a significant feature of schizophrenia. In this study, we compared fractional anisotropy (FA) of brain white matter between TRS and non–treatment-resistant schizophrenia (non-TRS) patients. Our central hypothesis was that TRS is associated with reduced FA values.MethodsTRS was defined as the persistence of moderate to severe symptoms after adequate treatment with at least two antipsychotics from different classes. Diffusion-tensor brain MRI obtained images from 34 TRS participants and 51 non-TRS. Whole-brain analysis of FA and axial, radial, and mean diffusivity were performed using Tract-Based Spatial Statistics (TBSS) and FMRIB’s Software Library (FSL), yielding a contrast between TRS and non-TRS patients, corrected for multiple comparisons using family-wise error (FWE) < 0.05.ResultsWe found a significant reduction in FA in the splenium of corpus callosum (CC) in TRS when compared to non-TRS. The antipsychotic dose did not relate to the splenium CC.ConclusionOur results suggest that the focal abnormality of CC may be a potential biomarker of TRS.
- Published
- 2021
- Full Text
- View/download PDF
42. Neurotransmitter receptor and regulatory gene expression in peripheral blood of Brazilian drug-naïve first-episode psychosis patients before and after antipsychotic treatment
- Author
-
Ota, Vanessa Kiyomi, Noto, Cristiano, Gadelha, Ary, Santoro, Marcos Leite, Silva, Patricia Natalia, Melaragno, Maria Isabel, Smith, Marília de Arruda Cardoso, Cordeiro, Quirino, Bressan, Rodrigo Affonseca, and Belangero, Sintia Iole
- Published
- 2013
- Full Text
- View/download PDF
43. Vascular loops in the anterior inferior cerebellar artery, as identified by magnetic resonance imaging, and their relationship with otologic symptoms
- Author
-
Abreu Junior, Luiz de, primary, Kuniyoshi, Cristina Hiromi, additional, Wolosker, Angela Borri, additional, Borri, Maria Lúcia, additional, Antunes, Augusto, additional, Ota, Vanessa Kiyomi Arashiro, additional, and Uchida, Daniela, additional
- Published
- 2016
- Full Text
- View/download PDF
44. DRD1 rs4532 polymorphism: A potential pharmacogenomic marker for treatment response to antipsychotic drugs
- Author
-
Ota, Vanessa Kiyomi, Spíndola, Letícia Nery, Gadelha, Ary, Santos Filho, Airton Ferreira dos, Santoro, Marcos Leite, Christofolini, Denise Maria, Bellucco, Fernanda Teixeira, Ribeiro-dos-Santos, Ândrea Kely, Santos, Sidney, Mari, Jair de Jesus, Melaragno, Maria Isabel, Bressan, Rodrigo Affonseca, Smith, Marilia de Arruda Cardoso, and Belangero, Sintia Iole
- Published
- 2012
- Full Text
- View/download PDF
45. Schizophrenia and 22q11 deletion syndrome: Characterization of relevant genes
- Author
-
Ota, Vanessa Kiyomi Arashiro [UNIFESP], Universidade Federal de São Paulo (UNIFESP), and Smith, Marilia de Arruda Cardoso [UNIFESP]
- Subjects
Genes ,Schizophrenia ,DiGeorge Syndrome ,Polimorfismo genético ,Esquizofrenia ,Polymorphism, genetic ,Síndrome de DiGeorge - Abstract
Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) Introdução: A esquizofrenia é o transtorno mental mais grave e incapacitante entre os distúrbios psiquiátricos. Ela é uma doença complexa e com fenótipo heterogêneo. Dentre os fatores genéticos que parecem ter um papel na etiologia da esquizofrenia está a deleção 22q11.2. Objetivos: Investigar alterações cromossômicas, polimorfismos dos genes UFD1L e ZDHHC8, mutações no gene TBX1 e variações no número de cópias na esquizofrenia e na síndrome da deleção 22q11.2, e correlacionar com achados de avaliações genético-clínicas, psiquiátricas, neuropsicológicas e de neuroimagem. Métodos: Um total de 200 portadores de esquizofrenia, 200 indivíduos controles e 10 portadores do fenótipo clínico da síndrome da deleção 22q11.2, mas sem a deleção, participaram do presente estudo. Os pacientes com esquizofrenia foram estudados por citogenética clássica e Multiplex Ligation-dependent probe amplification. Os polimorfismos rs5992403 (gene UFD1L) e rs175174 (gene ZDHHC8) foram investigados em pacientes com esquizofrenia e controles por meio de PCR em tempo real com sonda TaqMan. Outros polimorfismos do gene UFD1L foram analisados, rs5746744 e rs1547931, por Restriction Fragment Length Polymorphism. Mutações no gene TBX1 foram investigadas em portadores do fenótipo clínico da síndrome da deleção 22q11.2, mas sem a deleção, por meio de sequenciamento genômico. As variações no número de cópias foram analisadas por meio da metodologia de array em pools. Os pacientes com esquizofrenia também foram avaliados por testes neuropsicológicos e por neuroimagem estrutural. Resultados: Todos os cariótipos estudados foram normais. Foi encontrada um paciente com a deleção de 1,5 megabases na região 22q11.2. Os polimorfismos rs5992403 (UFD1L) e rs175174 (ZDHHC8) foram associados com a idade de acometimento da esquizofrenia. Além disso, todos os polimorfismos investigados parecem desempenhar um papel na morfologia cerebral e em habilidades cognitvas. Nenhuma mutação foi encontrada no gene TBX1, apenas polimorfismos, em portadores do fenótipo clínico da 22q11DS. Foram encontradas três regiões amplificadas em pools de DNAs de portadores de esquizofrenia: 1p36.32, 2q37.3 e 22q11.21. Conclusões: O estudo permitiu avaliar a participação de fatores genéticos em determinadas características da esquizofrenia, propiciando um melhor entendimento sobre a etiologia e fisiopatologia dessa doença complexa. Background: Schizophrenia is a severe, persistent, debilitating and poorly understood psychiatric disorder. It is a complex disease with heterogeneous fenotype. Among the genetic factors that might have a role in schizophrenia, it is included 22q11.2 deletion. Objectives: We aimed to investigate chromosomal abnormalities, UFD1L and ZDHHC8 polymorphisms, TBX1 mutations and copy number variations in schizophrenia and 22q11.2 deletion syndrome and associate them with clinical genetics, psychiatric, neuropsychological and neuroimaging data. Methodology: A total of 200 schizophrenia patients, 200 healthy controls and 10 patients who have the 22q11.2 syndrome phenotype but no detectable deletion were selected. Schizophrenia patients were investigated through classical karyotyping by G-banding and Multiplex Ligationdependent probe amplification. UFD1L rs5992403 and ZDHHC8 rs175174 polymorphisms were genotyped in schizophrenia patients and healthy controls by Real Time PCR using TaqMan. UFD1L rs5746744 and rs1547931 polymorphisms were genotyped by Restriction Fragment Length Polymorphism. Tbx1 mutations were investigated in patients who have the 22q11.2 syndrome phenotype but no detectable deletion by sequencing. Affymetrix 6.0 microarrays in a pool of DNA samples was used to detect copy number variations. Schizophrenia patients were evaluated by neuropsychological tests and structural neuroimaging. Results: All karyotypes were normal. One patient presented a 1.5 megabases deletion in 22q11.2 region. UFD1L rs5992403 and ZDHHC8 rs175174 polymorphisms were associated with age at onset of schizophrenia. Moreover, all studied polymorphisms may have a role in brain morphology and cognition. No mutation, only polymorphisms, in TBX1 gene was found in 22q11.2 patients. Three regions were amplified in DNA pools of schizophrenia patients: 1p36.32, 2q37.3 e 22q11.21. Conclusion: This study evaluated the role of genetic factors in some schizophrenia fenotypes, providing a better understanding of its etiology and pathophysiology. FAPESP: 2008/56464-7 TEDE BV UNIFESP: Teses e dissertações
- Published
- 2011
46. Depression, Cytokine, and Cytokine by Treatment Interactions Modulate Gene Expression in Antipsychotic Naïve First Episode Psychosis
- Author
-
Noto, Cristiano, primary, Ota, Vanessa Kiyomi, additional, Santoro, Marcos Leite, additional, Gouvea, Eduardo Sauerbronn, additional, Silva, Patricia Natalia, additional, Spindola, Leticia Maria, additional, Cordeiro, Quirino, additional, Bressan, Rodrigo Affonseca, additional, Gadelha, Ary, additional, Brietzke, Elisa, additional, Belangero, Sintia Iole, additional, and Maes, Michael, additional
- Published
- 2015
- Full Text
- View/download PDF
47. High predictive value of immune-inflammatory biomarkers for schizophrenia diagnosis and association with treatment resistance
- Author
-
Noto, Cristiano, primary, Maes, Michael, additional, Ota, Vanessa Kiyomi, additional, Teixeira, Antônio Lúcio, additional, Bressan, Rodrigo Affonseca, additional, Gadelha, Ary, additional, and Brietzke, Elisa, additional
- Published
- 2015
- Full Text
- View/download PDF
48. The UFD1L rs5992403 polymorphism is associated with age at onset of schizophrenia
- Author
-
Ota, Vanessa Kiyomi, Belangero, Sintia Iole, Gadelha, Ary, Bellucco, Fernanda Teixeira, Christofolini, Denise Maria, Mancini, Tatiane Iris, Ribeiro-dos-Santos, Ândrea Kelly, Santos, Sidney Emanuel, de Jesus Mari, Jair, Bressan, Rodrigo Affonseca, Melaragno, Maria Isabel, and de Arruda Cardoso Smith, Marilia
- Published
- 2010
- Full Text
- View/download PDF
49. Association of APOE, GCPII and MMP9 polymorphisms with common diseases and lipid levels in an older adult/elderly cohort
- Author
-
Mazzotti, Diego Robles, primary, Singulane, Cristiane Carvalho, additional, Ota, Vanessa Kiyomi, additional, Rodrigues, Thiago Potrich, additional, Furuya, Tatiane Katsue, additional, de Souza, Fernando José, additional, Cordeiro, Bruna Grassiela, additional, de Oliveira Amaral, Camilla Magalhães, additional, Chen, Elizabeth Suchi, additional, Jacomini, Anielli, additional, de Arruda Cardoso Smith, Marilia, additional, and Borsatto-Galera, Bianca, additional
- Published
- 2014
- Full Text
- View/download PDF
50. Linkage Replication for Chromosomal Region 13q32 in Schizophrenia: Evidence from a Brazilian Pilot Study on Early Onset Schizophrenia Families
- Author
-
Gadelha, Ary, primary, Ota, Vanessa Kiyomi, additional, Cano, Jose Paya, additional, Melaragno, Maria Isabel, additional, Smith, Marilia A. C., additional, de Jesus Mari, Jair, additional, Bressan, Rodrigo A., additional, Belangero, Sintia Iole, additional, and Breen, Gerome, additional
- Published
- 2012
- Full Text
- View/download PDF
Catalog
Discovery Service for Jio Institute Digital Library
For full access to our library's resources, please sign in.