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2. Clinical characteristics and factors related to infection with SCCmec type II and IV Methicillin-resistant Staphylococcus aureus in a Japanese secondary care facility: a single-center retrospective study

Author

Nakano, Yuki, Murata, Masayuki, Matsumoto, Yuji, Toyoda, Kazuhiro, Ota, Azusa, Yamasaki, Sho, Otakeno, Hisao, Yokoo, Kenjo, Shimono, Nobuyuki, Nakano, Yuki, Murata, Masayuki, Matsumoto, Yuji, Toyoda, Kazuhiro, Ota, Azusa, Yamasaki, Sho, Otakeno, Hisao, Yokoo, Kenjo, and Shimono, Nobuyuki

Abstract

Objectives: Differences in virulence genes, including psm-mec , which is a phenol-soluble modulin-mec (PSM-mec) encoding gene, of predominant staphylococcal cassette chromosome mec (SCCmec) types II and IV Methicillin-resistant Staphylococcus aureus (MRSA) may contribute to the virulence and clinical features of MRSA in Japan. We aimed to clarify the clinical characteristics and risk factors of infection among SCCmec types II and IV MRSA isolates from a Japanese secondary acute care hospital. / Methods: We analysed 58 SCCmec type II and 83 SCCmec type IV MRSA isolates collected from blood, central venous catheter tips, deep or superficial tissues, and sputum. / Results: SCCmec type II MRSA risk factors for progression to infection were seb , enterotoxin gene cluster, psm-me c mutation, and vancomycin minimum inhibitory concentrations (MIC) of 1 or 2 mg/L as viru- lence factors (adjusted odds ratio [aOR] = 11.8; 95% confidence interval [CI]: 2.49–77.7; P = 0.004); solid tumour was a host factor (aOR = 25.9; 95% CI: 3.66–300; P = 0.003). SCCmec type IV MRSA risk fac- tors were sea, cna , and vancomycin MIC of 1 or 2 mg/L as virulence factors (aOR = 3.14; 95% CI: 1.06–10.6; P = 0.049) and intravascular indwelling catheter as host factors (aOR = 3.78; 95% CI: 1.03–14.5; P = 0.045). Compared with SCCmec type II, SCCmec type IV MRSA resulted in more frequent bloodstream infections and higher Sequential Organ Failure Assessment scores. / Conclusion: We found that factors related to virulence genes and bacteriological and host characteristics are associated with SCCmec types II and IV MRSA infection and severity. These risk factors may be useful criteria for designing infection control programs.

Published
2023

3. Effects of gene–lifestyle interactions on obesity based on a multi-locus risk score: A cross-sectional analysis

Author

Nakamura, Sho, primary, Fang, Xuemin, additional, Saito, Yoshinobu, additional, Narimatsu, Hiroto, additional, Ota, Azusa, additional, Ikezaki, Hiroaki, additional, Shimanoe, Chisato, additional, Tanaka, Keitaro, additional, Kubo, Yoko, additional, Tsukamoto, Mineko, additional, Tamura, Takashi, additional, Hishida, Asahi, additional, Oze, Isao, additional, Koyanagi, Yuriko N., additional, Nakamura, Yohko, additional, Kusakabe, Miho, additional, Takezaki, Toshiro, additional, Nishimoto, Daisaku, additional, Suzuki, Sadao, additional, Otani, Takahiro, additional, Kuriyama, Nagato, additional, Matsui, Daisuke, additional, Kuriki, Kiyonori, additional, Kadota, Aya, additional, Nakamura, Yasuyuki, additional, Arisawa, Kokichi, additional, Katsuura-Kamano, Sakurako, additional, Nakatochi, Masahiro, additional, Momozawa, Yukihide, additional, Kubo, Michiaki, additional, Takeuchi, Kenji, additional, and Wakai, Kenji, additional

Published
2023
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5. A case of severe COVID-19 with pulmonary thromboembolism related to heparin-induced thrombocytopenia during prophylactic anticoagulation therapy

Author

Sasaki, Kosaku, primary, Murata, Masayuki, additional, Nakamura, Keiji, additional, Matsumoto, Yuji, additional, Nakashima, Yuko, additional, Yamasaki, Sho, additional, Ota, Azusa, additional, Hiramine, Satoshi, additional, Takayama, Koji, additional, Ikezaki, Hiroaki, additional, Toyoda, Kazuhiro, additional, Ogawa, Eiichi, additional, and Shimono, Nobuyuki, additional

Published
2022
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7. Clinical characteristics and factors related to infection with SCCmectype II and IV Methicillin-resistant Staphylococcus aureusin a Japanese secondary care facility: a single-center retrospective study

Author

Nakano, Yuki, Murata, Masayuki, Matsumoto, Yuji, Toyoda, Kazuhiro, Ota, Azusa, Yamasaki, Sho, Otakeno, Hisao, Yokoo, Kenjo, and Shimono, Nobuyuki

Abstract

•SCCmectype IV MRSA was prevalent in our hospital, but not as traditionally defined.•The proportion of psm-mecmutation in SCCmectype II MRSA harboring sebwas 89%.•SCCmectype IV MRSA harbored seaand cna(83%) but not PVL genes (lukF-PV/lukS-PV).•SCCmectype IV MRSA causes severe conditions and frequent bloodstream infections.•Infection factors were psm-mecmutation (type II MRSA), seaand cna(type IV MRSA).

Published
2022
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9. Mitochondrial nucleoid morphology and respiratory function are altered in Drp1-deficient HeLa cells.

Author

Ota, Azusa, Ishihara, Takaya, and Ishihara, Naotada

Subjects
*NUCLEOIDS, *HELA cells, *MITOCHONDRIAL DNA, *MORPHOLOGY, *OXYGEN consumption, *GENOME editing, *MITOCHONDRIA
Abstract

Mitochondria are dynamic organelles that frequently divide and fuse with each other. The dynamin-related GTPase protein Drp1 has a key role in mitochondrial fission. To analyse the physiological roles of Drp1 in cultured human cells, we analysed Drp1-deficient HeLa cells established by genome editing using CRISPR/Cas9. Under fluorescent microscopy, not only mitochondria were elongated but their DNA (mtDNA) nucleoids were extremely enlarged in bulb-like mitochondrial structures ('mito-bulbs') in the Drp1-deficient HeLa cells. We further found that respiratory activity, as measured by oxygen consumption rates, was severely repressed in Drp1-deficient HeLa cells and that this was reversible by the co-repression of mitochondrial fusion factors. Although mtDNA copy number was not affected, several respiratory subunits were repressed in Drp1-deficient HeLa cells. These results suggest that mitochondrial fission is required for the maintenance of active respiratory activity and the morphology of mtDNA nucleoids in human cells. [ABSTRACT FROM AUTHOR]

Published
2020
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