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16. Rectifying Electron-Transport Properties through Stacks of Aromatic Molecules Inserted into a Self-Assembled Cage

Author

Fujii, Shintaro, Tada, T., Komoto, Y., Osuga, T., Murase, T., Fujita, M., and Kiguchi, M.

Subjects
Chemistry, Conductance, Biasing, General Chemistry, Biochemistry, Molecular physics, Electron transport chain, Catalysis, Colloid and Surface Chemistry, Rectification, Computational chemistry, Molecule, Electronics, Break junction, Cage
Abstract

Aromatic stacks formed through self-assembly are promising building blocks for the construction of molecular electronic devices with adjustable electronic functions, in which noncovalently bound π-stacks act as replaceable modular components. Here we describe the electron-transport properties of single-molecule aromatic stacks aligned in a self-assembled cage, using scanning probe microscopic and break junction methods. Same and different modular aromatic pairs are noncovalently bound and stacked within the molecular cage holder, which leads to diverse electronic functions. The insertion of same pairs induces high electronic conductivity (10(-3)-10(-2) G0, G0 = 2e(2)/h), while different pairs develop additional electronic rectification properties. The rectification ratio was, respectively, estimated to be 1.4-2 and10 in current-voltage characteristics and molecular orientation-dependent conductance measurements at a fixed bias voltage. Theoretical calculations demonstrate that this rectification behavior originates from the distinct stacking order of the internal aromatic components against the electron-transport direction and the corresponding lowest unoccupied molecular orbital conduction channels localized on one side of the molecular junctions.

Published
2015

20. Serial measurement of pancreatic lipase immunoreactivity concentration in dogs with immune-mediated disease treated with prednisolone

Author

1000050431333, Ohta, H., Morita, T., Yokoyama, N., Osuga, T., 1000020302614, Sasaki, N., 1000030637046, Morishita, K., 1000080625898, Nakamura, K., 1000070261336, Takiguchi, M., 1000050431333, Ohta, H., Morita, T., Yokoyama, N., Osuga, T., 1000020302614, Sasaki, N., 1000030637046, Morishita, K., 1000080625898, Nakamura, K., 1000070261336, and Takiguchi, M.

Abstract

Objectives: In this pilot study, serum canine pancreatic lipase immunoreactivity was measured repeatedly in dogs with various immune-mediated diseases that were treated with immunosuppressive doses of prednisolone. Methods: Ten client-owned dogs with newly diagnosed immune-mediated disease that had normal canine pancreatic lipase immunoreactivity concentrations (200 mu g/l) were treated with 2 to 2.2 mg/kg prednisolone orally once daily as the initial treatment. Serum samples were obtained from each of the dogs prior to treatment and at 1- to 4-week intervals during immunosuppressive treatment. The highest canine pancreatic lipase immunoreactivity concentration detected during immunosuppressive treatment was defined as the peak canine pancreatic lipase immunoreactivity. Results: Peak canine pancreatic lipase immunoreactivity concentrations were classified as normal in two dogs, questionable (201 to 399 mu g/l) in three dogs, and abnormal (≥400 mu g/l) in five dogs. Peak canine pancreatic lipase immunoreactivity concentrations were significantly higher than baseline canine pancreatic lipase immunoreactivity concentrations but there was no evidence of clinical pancreatitis. Clinical Significance: It remains unclear whether the five of 10 dogs with elevated canine pancreatic lipase immunoreactivity during prednisone treatment had subclinical pancreatitis or whether the abnormal results were a consequence of prednisolone administration.

Published
2017

21. Serial measurement of pancreatic lipase immunoreactivity concentration in dogs with immune-mediated disease treated with prednisolone

Author

Ohta, H., Morita, T., Yokoyama, N., Osuga, T., Sasaki, N., Morishita, K., Nakamura, K., Takiguchi, M., Ohta, H., Morita, T., Yokoyama, N., Osuga, T., Sasaki, N., Morishita, K., Nakamura, K., and Takiguchi, M.

Abstract

Objectives: In this pilot study, serum canine pancreatic lipase immunoreactivity was measured repeatedly in dogs with various immune-mediated diseases that were treated with immunosuppressive doses of prednisolone. Methods: Ten client-owned dogs with newly diagnosed immune-mediated disease that had normal canine pancreatic lipase immunoreactivity concentrations (200 mu g/l) were treated with 2 to 2.2 mg/kg prednisolone orally once daily as the initial treatment. Serum samples were obtained from each of the dogs prior to treatment and at 1- to 4-week intervals during immunosuppressive treatment. The highest canine pancreatic lipase immunoreactivity concentration detected during immunosuppressive treatment was defined as the peak canine pancreatic lipase immunoreactivity. Results: Peak canine pancreatic lipase immunoreactivity concentrations were classified as normal in two dogs, questionable (201 to 399 mu g/l) in three dogs, and abnormal (≥400 mu g/l) in five dogs. Peak canine pancreatic lipase immunoreactivity concentrations were significantly higher than baseline canine pancreatic lipase immunoreactivity concentrations but there was no evidence of clinical pancreatitis. Clinical Significance: It remains unclear whether the five of 10 dogs with elevated canine pancreatic lipase immunoreactivity during prednisone treatment had subclinical pancreatitis or whether the abnormal results were a consequence of prednisolone administration.

Published
2017

25. Prognostic Value of Right Ventricular Tei Index in Dogs with Myxomatous Mitral Valvular Heart Disease

Author

1000080625898, Nakamura, K., Morita, T., Osuga, T., 1000030637046, Morishita, K., 1000020302614, Sasaki, N., 1000050431333, Ohta, H., 1000070261336, Takiguchi, M., 1000080625898, Nakamura, K., Morita, T., Osuga, T., 1000030637046, Morishita, K., 1000020302614, Sasaki, N., 1000050431333, Ohta, H., 1000070261336, and Takiguchi, M.

Abstract

Background: The right ventricular (RV) Tei index (TX) has a significant correlation with the severity of pulmonary hypertension. However, the role of RV dysfunction in dogs with myxomatous mitral valvular heart disease (MMVD) has not been addressed. Objectives: To investigate the correlation between right ventricular Tei-index (RVTX) and the prognosis for dogs with MMVD. Animals: Thirty client-owned dogs with MMVD. Methods: Clinical cohort study. Dogs were divided into two groups on the basis of the onset of cardiac-related death within 1 year of the first echocardiographic examination. Physical examination and echocardiographic variables were compared between the groups. Receiver operating characteristic (ROC) curves and multivariate logistic analysis were used to assess the comparative accuracy when identifying dogs with cardiac-related death. Results: The highest accuracy was obtained for RVTX with an area under the ROC curve (AUC) of 0.95 (95% confidence interval [CI] 0.81-0.99) followed by the left atrial to aortic root ratio with an AUC of 0.91 (95% CI 0.74-0.98), peak early diastolic mitral inflow velocity with an AUC of 0.84 (95% CI 0.64-0.94), and Doppler estimates of systolic pulmonary artery pressure with an AUC of 0.84 (95% CI 0.61-0.95). According to the multivariate logistic regression analysis, RVTX was the only independent correlate of cardiac-related death within 1 year. Conclusions and Clinical Importance: Right ventricular Tei-index has a strong correlation with the prognosis for dogs with MMVD. The most significant independent predictor of death was RVTX in this study.

Published
2016

26. Prognostic Value of Right Ventricular Tei Index in Dogs with Myxomatous Mitral Valvular Heart Disease

Author

Nakamura, K., Morita, T., Osuga, T., Morishita, K., Sasaki, N., Ohta, H., Takiguchi, M., Nakamura, K., Morita, T., Osuga, T., Morishita, K., Sasaki, N., Ohta, H., and Takiguchi, M.

Abstract

Background: The right ventricular (RV) Tei index (TX) has a significant correlation with the severity of pulmonary hypertension. However, the role of RV dysfunction in dogs with myxomatous mitral valvular heart disease (MMVD) has not been addressed. Objectives: To investigate the correlation between right ventricular Tei-index (RVTX) and the prognosis for dogs with MMVD. Animals: Thirty client-owned dogs with MMVD. Methods: Clinical cohort study. Dogs were divided into two groups on the basis of the onset of cardiac-related death within 1 year of the first echocardiographic examination. Physical examination and echocardiographic variables were compared between the groups. Receiver operating characteristic (ROC) curves and multivariate logistic analysis were used to assess the comparative accuracy when identifying dogs with cardiac-related death. Results: The highest accuracy was obtained for RVTX with an area under the ROC curve (AUC) of 0.95 (95% confidence interval [CI] 0.81-0.99) followed by the left atrial to aortic root ratio with an AUC of 0.91 (95% CI 0.74-0.98), peak early diastolic mitral inflow velocity with an AUC of 0.84 (95% CI 0.64-0.94), and Doppler estimates of systolic pulmonary artery pressure with an AUC of 0.84 (95% CI 0.61-0.95). According to the multivariate logistic regression analysis, RVTX was the only independent correlate of cardiac-related death within 1 year. Conclusions and Clinical Importance: Right ventricular Tei-index has a strong correlation with the prognosis for dogs with MMVD. The most significant independent predictor of death was RVTX in this study.

Published
2016

29. Abstracts of Selected Papers Presented at the 28th Annual Meeting of the Japanese Society of Gastroenterology Kanazawa, Japan, October 1–3,1986

Author

Tozuka, S., Esumi, M., Uchida, T., Shikata, T., Ogata, N., Kamimura, T., Ichida, F., Hamada, C., Matsumoto, Hisashi, Yoneyama, T., Miyamura, T., Mitamura, K., Osuga, T., Yaginuma, K., Morishima, T., Koike, K., Hino, Okio, Fujise, K., Nagamori, S., Kameda, H., Yokosuka, Osamu, Omata, Masao, Murakami, Seishi, Torino, T., Nakamura, T., Nagaya, A., Matsubara, K., Kimura, Akira, Sasagawa, Tsutomu, Higashi, A., Watanabe, Y., Iwashita, A., Yao, T., Imamura, K., Hibi, T., Watanabe, M., Asakura, H., Tsuchiya, M., Hiwatashi, Nobuo, Miura, Masaaki, Sasaki, I., Funayama, Y., Sato, T., Wang, C. Y., Huang, L. H., Wang, T. H., Sung, J. L., Hsu, S. C., How, S. W., Kobayashi, Kenzo, Nakamura, Hironobu, Taguchi, Tetsuo, Jinno, Kenji, Yumoto, Yasuhiro, Tanaka, Yutaka, Mitomi, Toshio, Ryu, Munemasa, Nagashima, Tohru, Majima, Yasuo, Tanikawa, Kyuichi, Fukuda, Yoshihiro, Hiraoka, Masahiro, Onishi, Saburo, Saibara, Toshiji, Imawari, Michio, Ishikawa, Takashi, Shimada, Tatsuji, Nakao, Norio, Kobayashi, Kenichi, Yamasaki, Susumu, Hasegawa, Hiroshi, Takayasu, Kenichi, Muramatsu, Yukio, Kinoshita, Hiroaki, Sakai, Katsuji, Higashi, Shunsaku, Mizumoto, Ryuji, Fujihara, Shiro, Okamoto, Eizo, Ochiai, Atsushi, Tahara, Eiichi, Yokota, Takashi, Takahashi, Toshio, Sunagawa, Masakatsu, Endo, Mitsuo, Imai, Kohzoh, Yachi, Akira, Hiraiwa, Nozomu, Fukuda, Yoshihiro, Chung, Yong-Suk, Satake, Katsusuke, Sugano, Kokichi, Ohkura, Hisanao, Takemori, Yasuhiro, Sawabu, Norio, Fujiyama, Shigetoshi, Morishita, Takafumi, Okuda, Hiroaki, and Obata, Hiroshi

Published
1987
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30. Transcranial Doppler Ultrasound Examination in Dogs with Suspected Intracranial Hypertension Caused by Neurologic Diseases.

Author

Sasaoka, K., Osuga, T., Morita, T., Yokoyama, N., Sasaki, N., Ohta, H., Takiguchi, M., Nakamura, K., and Morishita, K.

Subjects
*TRANSCRANIAL Doppler ultrasonography, *DIAGNOSIS of dog diseases, *INTRACRANIAL hypertension, *DIAGNOSIS of neurological disorders, *MAGNETIC resonance imaging, *BLOOD flow, *CROSS-sectional method, *DIAGNOSIS
Abstract

Background: Transcranial Doppler ultrasound examination (TCD) is a rapid, noninvasive technique used to evaluate cerebral blood flow and is useful for the detection of intracranial hypertension in humans. However, the clinical usefulness of TCD in diagnosing intracranial hypertension has not been demonstrated for intracranial diseases in dogs. Objectives: To determine the association between the TCD variables and intracranial hypertension in dogs with intracranial diseases. Animals: Fifty client‐owned dogs with neurologic signs. Methods: Cross‐sectional study. All dogs underwent TCD of the basilar artery under isoflurane anesthesia after magnetic resonance imaging (MRI). Dogs were classified into 3 groups based on MRI findings: no structural diseases (group I), structural disease without MRI evidence of intracranial hypertension (group II), and structural disease with MRI evidence of intracranial hypertension (group III). The TCD vascular resistance variables (resistive index [RI], pulsatility index [PI], and the ratio of systolic to diastolic mean velocity [Sm/Dm]) were measured. Results: Fifteen, 22, and 13 dogs were classified into groups I, II, and III, respectively. Dogs in group III had significantly higher Sm/Dm (median, 1.78; range, 1.44–2.58) than those in group I (median, 1.63; range, 1.43–1.75) and group II (median, 1.62; range, 1.27–2.10). No significant differences in RI and PI were identified among groups. Conclusions and Clinical Importance: Our findings suggest that increased Sm/Dm is associated with MRI findings of suspected intracranial hypertension in dogs with intracranial diseases and that TCD could be a useful tool to help to diagnose intracranial hypertension. [ABSTRACT FROM AUTHOR]

Published
2018
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31. General lectures (II)

Author

Karasawa, Y., Ōnuma, H., Suzuki, H., Okazaki, T., Yasui, A., Murakami, T., Furuya, K., Ohtsuki, M., Furuya, K., Ohtsuki, M., Sata, H., Kondo, T., Takada, H., Kawaguchi, K., Sai, S., Takeda, S., Kitagawa, M., Morooka, T., Shiraishi, T., Namiki, M., Kawauchi, H., Nakagawa, K., Kuramata, H., Yamaguchi, Y., Kabakino, T., Inokuchi, T., Wakisaka, J., Yamauchi, Y., Debuchi, T., Ogo, W., Yamasaki, C., Sigemori, M., Hashimoto, K., Shirozu, T., Kaibara, N., Inokuchi, K., Soejima, K., Hiyama, T., Wakita, M., Ikemoto, T., Hayasaka, H., Fukui, S., Takeda, T., Aoyama, N., Takada, Y., Saheki, Y., Yoshida, Y., Minagawa, K., Okuyama, T., Yamamitsu, S., Konishi, Y., Ishimatsu, N., Murai, S., Nukaga, A., Toyama, S., Watanabe, Y., Mizushima, N., Abe, M., Maruyama, K., Yoshino, K., Suzuki, T., Akisato, K., Kitajima, M., Tabata, T., Hashimoto, M., Tanaka, T., Nakagawa, Y., Ishii, Y., Inoue, M., Katayama, S., Nakano, Y., Fukuda, M., Takaki, M., Hyodo, H., Kobayashi, J., Nishikawa, H., Morimoto, K., Takagi, T., Sako, S., Tomoda, H., Soejima, K., Furusawa, M., Inokuchi, K., Sassa, R., Unuma, T., Iwase, T., Yoshioka, T., Kusakabe, M., Iio, M., Kobayashi, S., Kizu, M., Kasugai, T., Yoshida, K., Kembo, T., Yoshida, T., Suga, Y., Suguro, T., Kono, Y., Mitsui, S., Nagamachi, Y., Nakamura, T., Suto, H., Higuchi, T., Kobayashi, J., Onai, M., Isizuka, K., Takei, A., Simoda, M., Sekiguchi, T., Shichijo, K., Akashi, Y., Mori, K., Ogasawara, K., Tanaka, R., Yoshikawa, K., Takahashi, T., Ogata, T., Tanaka, S., Seito, T., Matsuda, H., Imajo, T., Moriyasu, K., Takata, Y., Kamei, H., Murai, H., Takemitsu, T., Kanemitsu, T., Ishii, M., Imaizumi, M., Kondo, T., Inada, M., Glass, G. B. J., Ebata, K., Yamanaka, N., Watanabe, S., Yoshida, Y., Mori, H., Tsukasa, S., Sato, H., Chuman, Y., Nakahara, N., Taniguchi, H., Ehira, S., Hori, M., Irisa, T., Yokoyama, H., Kunieda, T., Ogushi, Y., Kawakami, K., Kuroda, M., Kuroda, M., Sasaki, D., SŌma, S., Yanagiya, S., Munakata, A., Matsunaga, F., Abiko, M., Ohuchi, H., Tai, C., Kawashima, T., Oosawa, W., Asakura, H., Senba, H., Hatayama, T., Yukawa, K., Konishi, T., Miyata, M., Shimazu, H., Kinoshita, T., Nukada, K., Yamagishi, T., Harada, K., Nakano, S., Yoshioka, T., Sakai, T., Shindo, K., Fukushima, K., Odagiri, S., Tarao, K., Saito, Y., Ohara, K., Sasaki, S., Tomoda, T., Kaneda, N., Yamaguchi, H., Hayashi, T., Tanaka, T., Suzuki, J., Kofune, Y., Urase, A., Yamagata, A., Sugino, N., Hatano, M., Oshima, K., Tanabe, T., Ohto, M., Okuda, K., Mitani, E., Yamamoto, S., Kobayashi, K., Ono, T., Kamata, T., Mohri, S., Makiishi, H., Kitano, A., Suga, Y., Tatumi, S., Mizuno, S., Tsumori, K., Shimizu, T., Nomatsu, K., Hiratsuka, H., Ichinose, M., Asakura, H., Morishita, T., Morita, A., Matsuzaki, S., Oda, M., Kamegaya, K., Tuchiya, M., Sambe, K., Murakami, Y., Machii, A., Nitta, Y., Aiso, Y., Kitahara, N., Sato, M., Yoshizawa, Y., Hishinuma, Y., Nagasako, H., Nao, Y., Harada, H., Mishima, K., Yamagata, Y., Mandai, M., Kondo, Y., Uchida, Y., Takizawa, S., Kinoshita, S., Kurihara, T., Sakumoto, K., Okamoto, H., Sakurai, S., Ishitobi, S., Tanaka, H., Ishihara, K., Kuno, N., Kasugai, T., Aoki, I., Kizu, M., Nakano, S., Suzuki, T., Horiguchi, Y., Kitamura, K., Miwa, M., Okada, K., Takeda, T., Endo, Y., Tatsuta, M., Morii, T., Okuda, S., Tamura, H., Fukuda, K., Sato, K., Koizumi, K., Takebe, T., Yamagata, S., Noda, S., Toda, Y., Hayakawa, T., Nakajima, S., Hitokawa, S., Nakano, S., Suzuki, T., Takeda, T., Sawabu, N., Hirose, S., Takada, A., Takeuchi, J., Kuniyasu, Y., Kakehi, H., Uchiyama, G., Arimizu, N., Okuda, K., Ohto, M., Kuroda, T., Saishyo, H., Tanabe, T., Takashima, T., Shin, M., Akashi, M., Moriyama, T., Uchimura, M., Tsuchiya, R., Kakizaki, G., Noto, N., Oizumi, T., Soeno, T., Maeta, T., Saito, T., Naito, S., Saito, T., Shimizu, K., Nakajima, T., Tanaka, M., Kin, T., Sugiyama, S., Takayama, H., Tomono, T., Kamijo, N., Kimura, Y., Matsuo, T., Shimada, M., Terashima, B., Oda, M., Furuta, S., Kashiwabara, K., Oka, S., Sugiura, M., Karasawa, M., Ito, K., Takei, K., Ishihara, Y., Kuroda, A., Sato, N., Noro, T., Ishikawa, H., Tajima, Y., Hashihira, S., Nishii, T., Mori, R., Takeda, Y., Yamadori, T., Wakabayashi, A., Iwata, S., Shiraso, M., Tokutake, K., Sato, H., Matsuno, S., Haga, N., Saito, Y., Suda, Y., Sato, T., Kuroda, T., Tsunoda, T., Kamata, T., Kanno, H., Aneha, Y., Kikuchi, K., Abe, M., Imamura, K., Kondo, O., Yuki, Y., Omata, S., Okamoto, S., Nagahara, H., Motoyama, H., Watanabe, H., Maekawa, T., Miyakawa, T., Watanabe, Y., Anazawa, Y., Murakami, T., Motoyama, T., Kawamura, T., Kusaka, Y., Sugiura, M., Shima, F., Abe, S., Ichihara, S., Nomura, M., Ushiyama, T., Futagawa, S., Ishida, M., Obata, G., Sugiyama, Y., Suzuki, K., Abo, M., Takeuchi, M., Tann, E., Kimura, K., Iwaya, A., Takahashi, H., Ono, K., Inoue, J., Miyaishi, S., Sasaki, T., Kuroyanagi, Y., Sato, T., Kato, H., Kido, C., Hibino, K., Kishikawa, M., Takeuchi, T., Murate, H., Tanabe, A., Kozuka, M., Ito, M., Kato, N., Yazaki, Y., Goto, K., Miyaji, M., Suzuki, K., Ito, K., Yokoi, J., Endo, I., Kato, S., Miyazaki, M., Murayama, N., Kawamura, A., Ono, T., Ohto, M., Murohisa, B., Uchimura, M., Hirai, S., Akashi, M., Furukawa, M., Nakashima, G., Furuse, H., Tsuchiya, R., Fukuda, T., Hanyu, F., Sakakibara, N., Suzuki, H., Ide, H., Momma, K., Nagashima, H., Matsushiro, T., Suzuki, N., Saitoh, T., Nakamura, N., Takahashi, W., Maeta, T., Hatanaka, T., Kobayashi, N., Sato, T., Hagano, M., Furusawa, T., Osuga, T., Portman, O. W., Ogata, T., Tanaka, S., Takahashi, K., Kibayashi, H., Yamazaki, H., Komaki, K., Tanimura, H., Hikasa, Y., Ogawa, R., Nakagawa, H., Osada, M., Koizumi, H., Katayama, M., Sakamoto, H., Manome, T., Sesoko, M., Kobayashi, M., Komine, Y., Saito, Y., Watanabe, N., Okabe, Y., Ogino, M., Naruke, T., Hoshika, T., Miyano, T., Tsuneoka, K., Kitajima, S., Nakada, I., Sasamori, Y., Munakata, H., Tanaka, K., Oguro, H., Numata, T., Oh-Uti, K., Yoshida, Y., Goto, S., Yanagiya, S., Takashina, K., Matsunaga, F., Sasaki, G., Kimura, A., Sasagawa, T., Takahashi, G., Sugiyama, H., Iwaki, K., Okada, S., Koizumi, H., Iwasaki, M., Kawashima, Y., Kaneda, H., Takahashi, K., Honda, T., Ariga, K., Sa, Woo pak, Hozawa, H., Hiratsuka, H., Susuki, T., Kato, Y., Mizuno, T., Oya, H., Yoshino, S., and Hattori, T.

Published
1973
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32. 2298 Docetaxel, cisplatin and S-1 (DCS) combination chemotherapy for gastric cancer patients with peritoneal metastasis: a multi-institute retrospective study

Author

Sato, Y., primary, Ohnuma, H., additional, Hirakawa, M., additional, Osuga, T., additional, Okagawa, Y., additional, Sagawa, T., additional, Takahashi, Y., additional, Takahashi, M., additional, Maeda, M., additional, Katsuki, S., additional, Hirayama, M., additional, Kikuchi, S., additional, Murase, K., additional, Takada, K., additional, Sato, T., additional, Miyanishi, K., additional, Kobune, M., additional, Takimoto, R., additional, Takayama, T., additional, and Kato, J., additional

Published
2015
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34. Prognostic Value of Left Atrial Function in Dogs with Chronic Mitral Valvular Heart Disease

Author

Nakamura, K., Osuga, T., Morishita, K., Suzuki, S., Morita, T., Yokoyama, N., 1000050431333, Ohta, H., 1000040322846, Yamasaki, M., 1000070261336, Takiguchi, M., Nakamura, K., Osuga, T., Morishita, K., Suzuki, S., Morita, T., Yokoyama, N., 1000050431333, Ohta, H., 1000040322846, Yamasaki, M., 1000070261336, and Takiguchi, M.

Abstract

Background: A strong correlation between left atrial (LA) dysfunction and the severity of cardiac disease has been described in human patients with various cardiac diseases. The role of LA dysfunction in dogs with chronic mitral valvular heart disease (CMVHD) has not been addressed. Objectives: To investigate the correlation between LA function and the prognosis of dogs with CMVHD. Animals: Thirty-eight client-owned dogs with CMVHD. Methods: Prospective clinical cohort study. Dogs were divided into 2 groups (survivors and nonsurvivors) based on the onset of cardiac-related death within 1year. Physical examination and echocardiographic variables were compared between the groups. For the assessment of the comparative accuracy in identifying patients with cardiac-related death, receiver operating characteristic (ROC) curves and multivariate logistic analysis were used. Results: The highest accuracy was obtained for the LA active fractional area change (LA-FAC(act)), with an area under the ROC curve (AUC) of 0.95, followed by the left atrial to aortic root ratio (LA/Ao), with an AUC of 0.94; peak early diastolic mitral inflow velocity (E), with an AUC of 0.85; and LA total fractional area change (LA-FAC(total)), with an AUC of 0.85. In the multivariate logistic regression analysis, LA-FAC(act) emerged as the only independent correlate of cardiac-related death within 1year (odds ratio=1.401, P=.002). Conclusions and Clinical Importance: Regarding both the size and function, the LA has a strong correlation with the prognosis of dogs with CMVHD. The most significant independent predictor of mortality in this study was LA-FAC(act).

Published
2014

37. Early skin toxicity predicts better outcomes, and early tumor shrinkage predicts better response after cetuximab treatment in advanced colorectal cancer

Author

Kogawa, T., primary, Doi, A., additional, Shimokawa, M., additional, Fouad, T. M., additional, Osuga, T., additional, Tamura, F., additional, Mizushima, T., additional, Kimura, T., additional, Abe, S., additional, Ihara, H., additional, Kukitsu, T., additional, Sumiyoshi, T., additional, Yoshizaki, N., additional, Hirayama, M., additional, Sasaki, T., additional, Kawarada, Y., additional, Kitashiro, S., additional, Okushiba, S., additional, Kondo, H., additional, and Tsuji, Y., additional

Published
2014
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39. Magnetic resonance imaging of molecular transport in living morning glory stems

Author

Gussoni M., Greco F., Vezzoli A., Osuga T., and Zetta L.

Subjects
Quantitative Biology::Tissues and Organs
Abstract

MRI was applied to investigate the transport pathways in Morning Glory plant stems. The study was carried out on living plants without affecting their integrity. The architecture of a dicotyledonous plant was deeply characterized: the root system structure and the vascular bundle location were identified, the presence of central voids caused by cell maturation and loss were observed in the stem. Molecular transport components were recognized, by observing the concentration profile of a tracer, which changed with time after its absorption by the plant roots. MRI analysis revealed the presence of an axial transport as the progress of the tracer front through the vascular bundles and a radial molecular transport from the vascular bundles toward the surface of the stem. As a result, the tracer molecular transport formed the parabolic tracer front (PTF). A model was built up through the analysis of the PTF that consisted of an axial front at the peak position and a radial front at the width of the parabolic tail. PTF analysis revealed differences between the tracer transport velocities in the axial and the radial directions in the plant stem. The model revealed that the width of the parabolic tail reflected the magnitudes of diffusion and permeation of the tracer in the plant stem.

Published
2001

40. Fucosylated TGF-β receptors transduces a signal for epithelial–mesenchymal transition in colorectal cancer cells

Author

Hirakawa, M, primary, Takimoto, R, additional, Tamura, F, additional, Yoshida, M, additional, Ono, M, additional, Murase, K, additional, Sato, Y, additional, Osuga, T, additional, Sato, T, additional, Iyama, S, additional, Miyanishi, K, additional, Takada, K, additional, Hayashi, T, additional, Kobune, M, additional, and Kato, J, additional

Published
2013
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43. Quantitative Contrast-enhanced Ultrasonographic Assessment of Naturally Occurring Pancreatitis in Dogs.

Author

Lim, S.Y., Nakamura, K., Morishita, K., Sasaki, N., Murakami, M., Osuga, T., Yokoyama, N., Ohta, H., Yamasaki, M., and Takiguchi, M.

Subjects
PANCREATITIS diagnosis, DOG diseases, ULTRASONIC imaging, HISTOPATHOLOGY, VETERINARY medicine, NECROSIS
Abstract

Background Quantitative contrast-enhanced ultrasonography ( CEUS) can detect pancreatic perfusion changes in experimentally induced canine pancreatitis. However, its usefulness in detecting perfusion changes in naturally occurring pancreatitis is unclear. Hypothesis/Objectives To determine the feasibility of using CEUS to detect pancreatic and duodenal perfusion changes in naturally occurring canine pancreatitis. Animals Twenty-three client-owned dogs with pancreatitis, 12 healthy control dogs. Methods Dogs diagnosed with pancreatitis were prospectively included. CEUS of the pancreas and duodenum were performed. Time-intensity curves were created from regions of interest in the pancreas and duodenum. Five perfusion parameters were obtained for statistical analyses: time to initial up-slope, peak time ( Tp), time to wash-out ( TTW), peak intensity ( PI), and area under the curve ( AUC). Results For the pancreas, Tp of the pancreatitis group was prolonged when compared to controls (62 ± 11 seconds versus 39 ± 13 seconds; P < .001). TTW also was prolonged but not significantly (268 ± 69 seconds versus 228 ± 47 seconds; P = .47). PI and AUC were increased when compared to controls (95 ± 15 versus 78 ± 13 MPV; P = .009 and 14,900 ± 3,400 versus 11,000 ± 2,800 MPV*s; P = .013, respectively). For the duodenum, PI and AUC were significantly increased in the pancreatitis group when compared to controls. Conclusions and Clinical Importance Contrast-enhanced ultrasonography can detect pancreatic perfusion changes in naturally occurring canine pancreatitis characterized by delayed peak with prolonged hyperechoic enhancement of the pancreas on CEUS. Additionally, duodenal perfusion changes secondary to pancreatitis were observed. [ABSTRACT FROM AUTHOR]

Published
2015
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46. Fucosylated TGF-β receptors transduces a signal for epithelial-mesenchymal transition in colorectal cancer cells.

Author

Hirakawa, M, Takimoto, R, Tamura, F, Yoshida, M, Ono, M, Murase, K, Sato, Y, Osuga, T, Sato, T, Iyama, S, Miyanishi, K, Takada, K, Hayashi, T, Kobune, M, and Kato, J

Subjects
COLON cancer, CANCER cell proliferation, TRANSFORMING growth factors, CELLULAR signal transduction, EPITHELIAL cells, MESENCHYMAL stem cells
Abstract

Background:Transforming growth factor-β (TGF-β) is a major inducer of epithelial-mesenchymal transition (EMT) in different cell types. TGF-β-mediated EMT is thought to contribute to tumour cell spread and metastasis. Sialyl Lewis antigens synthesised by fucosyltransferase (FUT) 3 and FUT6 are highly expressed in patients with metastatic colorectal cancer (CRC) and are utilised as tumour markers for cancer detection and evaluation of treatment efficacy. However, the role of FUT3 and FUT6 in augmenting the malignant potential of CRC induced by TGF-β is unclear.Methods:Colorectal cancer cell lines were transfected with siRNAs for FUT3/6 and were examined by cell proliferation, invasion and migration assays. The expression and phosphorylation status of TGF-β downstream molecules were analysed by western blot. Fucosylation of TGF-β receptor (TβR) was examined by lectin blot analysis.Results:Inhibition of FUT3/6 expression by siRNAs suppressed the fucosylation of type I TβR and phosphorylation of the downstream molecules, thereby inhibiting the invasion and migration of CRC cells by EMT.Conclusion:Fucosyltransferase 3/6 has an essential role in cancer cell adhesion to endothelial cells by upregulation of sialyl Lewis antigens and also by enhancement of cancer cell migration through TGF-β-mediated EMT. [ABSTRACT FROM AUTHOR]

Published
2014
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