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294 results on '"Osti, Mattia Falchetto"'

1. Re-irradiation for recurrent intracranial meningiomas: Analysis of clinical outcomes and prognostic factors

Author

Desideri, Isacco, Morelli, Ilaria, Banini, Marco, Greto, Daniela, Visani, Luca, Nozzoli, Filippo, Caini, Saverio, Della Puppa, Alessandro, Livi, Lorenzo, Perini, Zeno, Zivelonghi, Emanuele, Bulgarelli, Giorgia, Pinzi, Valentina, Navarria, Pierina, Clerici, Elena, Scorsetti, Marta, Ascolese, Anna Maria, Osti, Mattia Falchetto, Anselmo, Paola, Amelio, Dante, Minniti, Giuseppe, and Scartoni, Daniele

Published
2024
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2. PERSIAN trial (NCT05717660): an ongoing randomized trial testing androgen deprivation therapy, apalutamide and stereotactic body radiotherapy. An alternative “triplet” for oligometastatic hormone sensitive prostate cancer patients

Author

Francolini, Giulio, Porreca, Angelo, Facchini, Gaetano, Santini, Daniele, Bruni, Alessio, Simoni, Nicola, Trovò, Marco, Osti, Mattia Falchetto, Fornarini, Giuseppe, Sisani, Michele, Di Cataldo, Vanessa, Detti, Beatrice, Garlatti, Pietro, Bertini, Niccolò, Serni, Sergio, Minervini, Andrea, and Livi, Lorenzo

Published
2024
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3. Management of radiation-induced oral mucositis in head and neck cancer patients: a real-life survey among 25 Italian radiation oncology centers

Author

Bergamaschi, Luca, Vincini, Maria Giulia, Zaffaroni, Mattia, Pepa, Matteo, Angelicone, Ilaria, Astone, Antonio, Bergamini, Cristiana, Buonopane, Sergio, Conte, Mario, De Rosa, Nicola, Deantoni, Chiara, Dell’Oca, Italo, Di Gennaro, Davide, Di Muzio, Nadia, Osti, Mattia Falchetto, Federico, Manuela, Ferini, Gianluca, Franzese, Ciro, Gatti, Marco, Grillo, Antonietta, Iorio, Vincenzo, Manzo, Roberto, Marmiroli, Luca, Martin, Giuseppe, Mazzuca, Federica, Molinaro, Maria Angela, Muto, Matteo, Pacelli, Roberto, Pepe, Alfonsina, Perillo, Annarita, Russo, Donatella, Salerno, Francesca, Spadaro, Pietro, Viola, Anna, Iorio, Giuseppe Carlo, Muto, Paolo, Ricardi, Umberto, and Alterio, Daniela

Published
2024
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5. A predictive model of polymetastatic disease from a multicenter large retrospectIve database on colorectal lung metastases treated with stereotactic ablative radiotherapy: The RED LaIT-SABR study

Author

Nicosia, Luca, Franceschini, Davide, Perrone-Congedi, Francesca, Molinari, Alessandro, Gerardi, Marianna Alessandra, Rigo, Michele, Mazzola, Rosario, Perna, Marco, Scotti, Vieri, Fodor, Andrei, Iurato, Aurelia, Pasqualetti, Francesco, Gadducci, Giovanni, Chiesa, Silvia, Niespolo, Rita Marina, Bruni, Alessio, Cappelli, Anna, D'Angelo, Elisa, Borghetti, Paolo, Di Marzo, Alessandro, Ravasio, Andrea, De Bari, Berardino, Sepulcri, Matteo, Aiello, Dario, Mortellaro, Gianluca, Sangalli, Claudia, Franceschini, Marzia, Montesi, Giampaolo, Aquilanti, Francesco Maria, Lunardi, Gianluigi, Valdagni, Riccardo, Fazio, Ivan, Scarzello, Giovanni, Vavassori, Vittorio, Maranzano, Ernesto, Maria Magrini, Stefano, Arcangeli, Stefano, Gambacorta, Maria Antonietta, Valentini, Vincenzo, Paiar, Fabiola, Ramella, Sara, Di Muzio, Nadia Gisella, Loi, Mauro, Jereczek-Fossa, Barbara Alicja, Casamassima, Franco, Osti, Mattia Falchetto, Scorsetti, Marta, and Alongi, Filippo

Published
2023
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10. Leptomeningeal Carcinomatosis in Early Gastric Cancer: A Case Report and Literature Review.

Author

Lucarini, Alessio, Arrivi, Giulia, Liotta, Elena, Li Causi, Francesco Saverio, Di Cicco, Leonardo, Mazzuca, Federica, Osti, Mattia Falchetto, Balducci, Genoveffa, and Mercantini, Paolo

Subjects
WEIGHT loss, CYTOLOGY, ABDOMEN, STOMACH tumors, DIFFERENTIAL diagnosis, ASTHENIA, BRAIN, COMPUTED tomography, MENINGEAL cancer, MAGNETIC resonance imaging, METASTASIS, GASTROSCOPY, CACHEXIA, DEGLUTITION disorders, HEALTH care teams, COMORBIDITY, DISEASE complications
Abstract

Leptomeningeal carcinomatosis (LC) is a rare site of metastasis in solid tumors, and it is associated with poor prognosis due to disabling symptoms and a scarcity of treatment options. This condition is an uncommon entity in gastric cancer (GC). We present a case of primary LC manifestation in a patient with an incidental diagnosis of localized node-negative GC. We additionally perform a literature review and discuss the diagnostic and therapeutic challenges. In conclusion, LC from GC represents a rare condition with a dramatic prognosis. Its diagnosis might be very challenging. A multidisciplinary approach appears to be the best strategy for the management of LC from GC. [ABSTRACT FROM AUTHOR]

Published
2024
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13. Low Anterior Resection Syndrome (LARS) after Surgery for Rectal Cancer: An Inevitable Price to Pay for Survival, or a Preventable Complication?

Author

Muttillo, Edoardo Maria, primary, La Franca, Alice, additional, Coppola, Alessandro, additional, Li Causi, Francesco Saverio, additional, Checchelani, Marzia, additional, Ceccacci, Alice, additional, Castagnola, Giorgio, additional, Garbarino, Giovanni Maria, additional, Osti, Mattia Falchetto, additional, Balducci, Genoveffa, additional, and Mercantini, Paolo, additional

Published
2023
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14. Response to Tugcu et al

Author

Desideri, Isacco, Morelli, Ilaria, Banini, Marco, Greto, Daniela, Visani, Luca, Nozzoli, Filippo, Caini, Saverio, Della Puppa, Alessandro, Livi, Lorenzo, Perini, Zeno, Zivelonghi, Emanuele, Bulgarelli, Giorgia, Pinzi, Valentina, Navarria, Pierina, Clerici, Elena, Scorsetti, Marta, Ascolese, Anna Maria, Osti, Mattia Falchetto, Anselmo, Paola, Amelio, Dante, Minniti, Giuseppe, and Scartoni, Daniele

Published
2024
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18. Time to surgery and pathologic complete response after neoadjuvant chemoradiation in rectal cancer: A population study on 2094 patients

Author

Macchia, Gabriella, Gambacorta, Maria Antonietta, Masciocchi, Carlotta, Chiloiro, Giuditta, Mantello, Giovanna, di Benedetto, Maika, Lupattelli, Marco, Palazzari, Elisa, Belgioia, Liliana, Bacigalupo, Almalina, Sainato, Aldo, Montrone, Sabrina, Turri, Lucia, Caroli, Angela, De Paoli, Antonino, Matrone, Fabio, Capirci, Carlo, Montesi, Giampaolo, Niespolo, Rita Marina, Osti, Mattia Falchetto, Caravatta, Luciana, Galardi, Alessandra, Genovesi, Domenico, Rosetto, Maria Elena, Boso, Caterina, Sciacero, Piera, Giaccherini, Lucia, Parisi, Salvatore, Fontana, Antonella, Filippone, Francesco Romeo, Picardi, Vincenzo, Morganti, Alessio Giuseppe, and Valentini, Vincenzo

Published
2017
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19. Apalutamide and stereotactic body radiation therapy for low-burden, metastatic, hormone-sensitive prostate cancer: A randomized trial (PERSIAN).

Author

Francolini, Giulio, Porreca, Angelo, Facchini, Gaetano, Santini, Daniele, Bruni, Alessio, Simoni, Nicola, Trovò, Marco, Osti, Mattia Falchetto, Fornarini, Giuseppe, Sisani, Michele, Di Cataldo, Vanessa, Detti, Beatrice, Garlatti, Pietro, Bertini, Niccolò, Burchini, Luca, Frosini, Giulio, Bonaparte, Ilaria, Serni, Sergio, Minervini, Andrea, and Livi, Lorenzo

Published
2024
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20. Preoperative Intensified Chemoradiation with Intensity-Modulated Radiotherapy and Simultaneous Integrated Boost Combined with Capecitabine in Locally Advanced Rectal Cancer: Long-Term Outcomes of a Real-Life Multicenter Study.

Author

Lupattelli, Marco, Palazzari, Elisa, Polesel, Jerry, Chiloiro, Giuditta, Angelicone, Ilaria, Panni, Valeria, Caravatta, Luciana, Di Biase, Saide, Macchia, Gabriella, Niespolo, Rita Marina, Franco, Pierfrancesco, Epifani, Valeria, Meldolesi, Elisa, de Giacomo, Flavia, Lucarelli, Marco, Montesi, Giampaolo, Mantello, Giovanna, Innocente, Roberto, Osti, Mattia Falchetto, and Gambacorta, Maria Antonietta

Subjects
THERAPEUTIC use of antimetabolites, PREOPERATIVE care, RESEARCH, CONFIDENCE intervals, RECTUM tumors, RETROSPECTIVE studies, MAGNETIC resonance imaging, POSITRON emission tomography computed tomography, TUMOR classification, CHEMORADIOTHERAPY, TREATMENT effectiveness, RADIATION doses, DESCRIPTIVE statistics, KAPLAN-Meier estimator, RADIOTHERAPY, DATA analysis software, ODDS ratio, PROPORTIONAL hazards models, EVALUATION
Abstract

Simple Summary: Preoperative chemoradiation (CRT) for rectal cancer with the intensification of radiotherapy (RT) using dose escalation to the tumor volume has been shown effective in improving tumor regression with high compliance to treatment and low toxicity rates. Most dose-escalation trials used conventional 3D conformal RT with concurrent capecitabine. More recently, phase I-II trials investigated intensified RT programs with advanced intensity-modulated RT and simultaneous boost (IMRT-SIB) supported by image-guided RT (IGRT) techniques, highlighting their feasibility and promising activity. However, only limited data on long-term outcomes are available. We analyzed the long-term results of a retrospective, multicenter experience with preoperative capecitabine-based CRT intensification with IMRT-SIB in real-life clinical practice in 10 Italian institutions. The use of moderate IMRT-SIB dose intensification with a full dose of concurrent capecitabine was safe and well tolerated. In addition, an organ preservation strategy has been shown feasible in carefully selected, responsive patients with a promising long-term rectal preservation rate. Long-term local control, progression-free and overall survival rates compared favorably with conventional CRT trials. Given the higher incidence of distant metastases in the subset of high-risk patients, the incorporation of IMRT-SIB and capecitabine with a more effective systemic therapy component may represent a new area of investigational interest while the use of IMRT-SIB and capecitabine in a primarily organ-preservation strategy may be a valuable option for low-intermediate-risk patients. Background: Despite the feasibility and promising activity data on intensity-modulated RT and simultaneous integrated boost (IMRT-SIB) dose escalation in preoperative chemoradiation (CRT) for locally advanced rectal cancer (LARC), few data are currently available on long-term outcomes. Patients and Methods: A cohort of 288 LARC patients with cT3-T4, cN0-2, cM0 treated with IMRT-SIB and capecitabine from March 2013 to December 2019, followed by a total mesorectal excision (TME) or an organ-preserving strategy, was collected from a prospective database of 10 Italian institutions. A dose of 45 Gy in 25 fractions was prescribed to the tumor and elective nodes, while the SIB dose was prescribed according to the clinical practice of each institution on the gross tumor volume (GTV). Concurrent capecitabine was administered at a dose of 825 mg/m2 twice daily, 7 days a week. The primary objective of the study was to evaluate long-term outcomes in terms of local control (LC), progression-free survival (PFS) and overall survival (OS). The secondary objective was to confirm the previously reported feasibility, safety and efficacy (pCR, TRG1-2 and downstaging rates) of the treatment in a larger patient population. Results: All patients received a dose of 45 Gy to the tumor and elective nodes, while the SIB dose ranged from 52.5 Gy to 57.5 Gy (median 55 Gy). Acute gastrointestinal and hematologic toxicity rates of grade 3–4 were 5.7% and 1.8%, respectively. At preoperative restaging, 36 patients (12.5%) with complete or major clinical responses (cCR or mCR) were offered an organ-preserving approach with local excision (29 patients) or a watch and wait strategy (7 patients). The complete pathologic response rate (pCR) in radically operated patients was 25.8%. In addition, 4 TME patients had pT0N1 and 19 LE patients had pT0Nx, corresponding to an overall pT0 rate of 31.3%. Of the 36 patients selected for organ preservation, 7 (19.5%) required the completion of TME due to unfavorable pathologic features after LE or tumor regrowth during W-W resulting in long-term rectal preservation in 29 of 288 (10.1%) of the total patient population. Major postoperative complications occurred in 14.2% of all operated patients. At a median follow-up of 50 months, the 5-year PFS and OS rates were 72.3% (95% CI: 66.3–77.4) and 85.9% (95% CI: 80.2–90.1), respectively. The 5-year local recurrence (LR) rate was 9.2% (95% CI: 6.0–13.2), while the distant metastasis (DM) rate was 21.3% (95% CI: 16.5–26.5). The DM rate was 24.5% in the high-risk subset compared to 16.2% in the low-intermediate risk group (p = 0.062) with similar LR rates (10% and 8%, respectively). On multivariable analysis, cT4 and TRG3–5 were significantly associated with worse PFS, OS and metastasis-free survival. Conclusions: Preoperative IMRT-SIB with the moderate dose intensification of 52.5–57.5 Gy (median 55 Gy) and the full dose of concurrent capecitabine confirmed to be feasible and effective in our real-life clinical practice. Organ preservation was shown to be feasible in carefully selected, responsive patients. The favorable long-term survival rates highlight the efficacy of this intensified treatment program. The incorporation of IMRT-SIB with a more effective systemic therapy component in high-risk patients could represent a new area of investigational interest. [ABSTRACT FROM AUTHOR]

Published
2023
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21. Efficacy of Residual Site Radiation Therapy (ISRT) in Patients with Primary Mediastinal Lymphoma with Deauville Score 4 Following R-CHT: Results of a Retrospective Mono Institutional Study

Author

Facondo, Giuseppe, primary, Serio, Mattia, additional, Vullo, Gianluca, additional, Bianchi, Maria Paola, additional, Pelliccia, Sabrina, additional, Di Rocco, Alice, additional, Lanzolla, Tiziana, additional, Valeriani, Maurizio, additional, Di Napoli, Arianna, additional, Tafuri, Agostino, additional, Martelli, Maurizio, additional, Osti, Mattia Falchetto, additional, and De Sanctis, Vitaliana, additional

Published
2023
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22. Lymph Node Metastasis in Extraperitoneal Rectal Cancer After Neoadjuvant Therapy: An Unsolved Problem?

Author

LA FRANCA, ALICE, primary, MUTTILLO, EDOARDO MARIA, additional, MADAFFARI, ISABELLA, additional, MASSIMI, FANNY, additional, LONGO, GIUSEPPE, additional, CECCACCI, ALICE, additional, ANGELICONE, ILARIA, additional, DE GIACOMO, FLAVIA, additional, SPERDUTI, ISABELLA, additional, BALDUCCI, GENOVEFFA, additional, OSTI, MATTIA FALCHETTO, additional, and MERCANTINI, PAOLO, additional

Published
2023
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23. Clinical Outcomes and Toxicity of CT-guided High Dose-rate Brachytherapy in Women With Locally-advanced Cervical Cancer

Author

DE SANCTIS, VITALIANA, primary, FACONDO, GIUSEPPE, additional, VULLO, GIANLUCA, additional, ANZELLINI, DIMITRI, additional, SANGUINETI, GIUSEPPE, additional, NARDANGELI, ALESSIA, additional, MARMIROLI, LUCA, additional, TORTORETO, FRANCESCA, additional, GENTILE, PIERCARLO, additional, ANNESSI, IVAN, additional, DONATO, VITTORIO, additional, CHIOSTRINI, CINZIA, additional, TOMBOLINI, VINCENZO, additional, DE FELICE, FRANCESCA, additional, VALERIANI, MAURIZIO, additional, and OSTI, MATTIA FALCHETTO, additional

Published
2023
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24. Re-irradiation with curative intent in patients with squamous cell carcinoma of the head and neck: a national survey of usual practice on behalf of the Italian Association of Radiation Oncology (AIRO)

Author

Maddalo, Marta, Bonomo, Pierluigi, Belgioia, Liliana, Bacigalupo, Almalina, Donato, Vittorio, Alterio, Daniela, Orlandi, Ester, Argenone, Angela, Merlotti, Anna, Musio, Daniela, Trignani, Marianna, Ursino, Stefano, Arcangeli, Stefano, Furlan, Carlo, Osti, Mattia Falchetto, and On behalf of the Italian Association of Radiation Oncology (AIRO)

Published
2017
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33. AIRO Breast Cancer Group Best Clinical Practice 2022 Update

Author

Ciabattoni, Antonella, primary, Gregucci, Fabiana, additional, De Rose, Fiorenza, additional, Falivene, Sara, additional, Fozza, Alessandra, additional, Daidone, Antonio, additional, Morra, Anna, additional, Smaniotto, Daniela, additional, Barbara, Raffaele, additional, Lozza, Laura, additional, Vidali, Cristiana, additional, Borghesi, Simona, additional, Palumbo, Isabella, additional, Huscher, Alessandra, additional, Perrucci, Elisabetta, additional, Baldissera, Antonella, additional, Tolento, Giorgio, additional, Rovea, Paolo, additional, Franco, Pierfrancesco, additional, De Santis, Maria Carmen, additional, Grazia, Alfio Di, additional, Marino, Lorenza, additional, Meduri, Bruno, additional, Cucciarelli, Francesca, additional, Aristei, Cynthia, additional, Bertoni, Filippo, additional, Guenzi, Marina, additional, Leonardi, Maria Cristina, additional, Livi, Lorenzo, additional, Nardone, Luigia, additional, De Felice, Francesca, additional, Rosetto, Maria Elena, additional, Mazzuoli, Lidia, additional, Anselmo, Paola, additional, Arcidiacono, Fabio, additional, Barbarino, Rosaria, additional, Martinetti, Mariateresa, additional, Pasinetti, Nadia, additional, Desideri, Isacco, additional, Marazzi, Fabio, additional, Ivaldi, Giovanni, additional, Bonzano, Elisabetta, additional, Cavallari, Monica, additional, Cerreta, Vincenzo, additional, Fusco, Vincenzo, additional, Sarno, Laura, additional, Bonanni, Alessio, additional, Mangiacotti, Maria Grazia, additional, Prisco, Agnese, additional, Buonfrate, Giovanna, additional, Andrulli, Damiana, additional, Fontana, Antonella, additional, Bagnoli, Rita, additional, Marinelli, Luca, additional, Reverberi, Chiara, additional, Scalabrino, Giovanna, additional, Corazzi, Francesca, additional, Doino, Daniela, additional, Di Genesio-Pagliuca, Milena, additional, Lazzari, Mariagrazia, additional, Mascioni, Francesca, additional, Pace, Maria Paola, additional, Mazza, Mirko, additional, Vitucci, Pasquale, additional, Spera, Antonio, additional, Macchia, Gabriella, additional, Boccardi, Mariangela, additional, Evangelista, Giovanna, additional, Sola, Barbara, additional, La Porta, Maria Rosa, additional, Fiorentino, Alba, additional, Levra, Niccolò Giaj, additional, Ippolito, Edy, additional, Silipigni, Sonia, additional, Osti, Mattia Falchetto, additional, Mignogna, Marcello, additional, Alessandro, Marina, additional, Ursini, Lucia Anna, additional, Nuzzo, Marianna, additional, Meattini, Icro, additional, and D’Ermo, Giuseppe, additional

Published
2022
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35. External validation of a composite bio-humoral index in anal cancer patients undergoing concurrent chemoradiation

Author

Franco, Pierfrancesco, Porreca, Annamaria, Mantello, Giovanna, Valvo, Francesca, Gasparini, Lucrezia, Slim, Najla, Manfrida, Stefania, De Felice, Francesca, Gerardi, Marianna A, Vagge, Stefano, Krengli, Marco, Palazzari, Elisa, Osti, Mattia Falchetto, Gonnelli, Alessandra, Catalano, Gianpiero, Pittoni, Patrizia, Ivaldi, Giovani B, Lupattelli, Marco, Rosetto, Maria Elena, Niespolo, Rita Marina, Guido, Alessandra, Durante, Oreste, Macchia, Gabriella, Munoz, Fernando, El Khouzai, Badr, Lucido, Maria Rosaria, Arcadipane, Francesca, Casadei Gardini, Andrea, Maria D'Angelillo, Rolando, Gambacorta, Maria Antonietta, Genovesi, Domenico, Di Nicola, Marta, Caravatta, Luciana, Gambacorta, Maria Antonietta (ORCID:0000-0001-5455-8737), Franco, Pierfrancesco, Porreca, Annamaria, Mantello, Giovanna, Valvo, Francesca, Gasparini, Lucrezia, Slim, Najla, Manfrida, Stefania, De Felice, Francesca, Gerardi, Marianna A, Vagge, Stefano, Krengli, Marco, Palazzari, Elisa, Osti, Mattia Falchetto, Gonnelli, Alessandra, Catalano, Gianpiero, Pittoni, Patrizia, Ivaldi, Giovani B, Lupattelli, Marco, Rosetto, Maria Elena, Niespolo, Rita Marina, Guido, Alessandra, Durante, Oreste, Macchia, Gabriella, Munoz, Fernando, El Khouzai, Badr, Lucido, Maria Rosaria, Arcadipane, Francesca, Casadei Gardini, Andrea, Maria D'Angelillo, Rolando, Gambacorta, Maria Antonietta, Genovesi, Domenico, Di Nicola, Marta, Caravatta, Luciana, and Gambacorta, Maria Antonietta (ORCID:0000-0001-5455-8737)

Abstract

Background and purpose: A prognostic scoring system based on laboratory inflammation parameters, [Hemo-Eosinophils-Inflammation (HEI) index], including baseline hemoglobin level, the systemic inflam-matory index and eosinophil count was recently proposed in patients with squamous cell carcinoma of the anus (ASCC). HEI was shown to discriminate disease-free (DFS) and overall (OS) survival in ASCC patients treated with concurrent chemoradiation (CRT). We tested the accuracy of the model on a mul-ticentric cohort for external validation.Materials and methods: Patients treated with CRT were enrolled. The Kaplan-Meier curves for DFS and OS based on HEI risk group were calculated and the log-rank test was used. Cox proportional hazards models were used to assess the prognostic factors for DFS and OS. The exponential of the regression coefficients provided an estimate of the hazard ratio (HR). For model discrimination, we determined Harrell's C -index, Gonen & Heller K Index and the explained variation on the log relative hazard scale.Results: A total of 877 patients was available. Proportional hazards were adjusted for age, gender, tumor -stage, and chemotherapy. Two-year DFS was 77 %(95 %CI:72.0-82.4) and 88.3 %(95 %CI:84.8-92.0 %) in the HEI high-and low-risk groups. Two-year OS was 87.8 %(95 %CI:83.7-92.0) and 94.2 %(95 %CI:91.5- 97). Multivariate Cox proportional hazards model showed a HR = 2.02(95 %CI:1.25-3.26; p = 0.004) for the HEI high-risk group with respect to OS and a HR = 1.53(95 %CI:1.04-2.24; p = 0.029) for DFS. Harrel C-indexes were 0.68 and 0.66 in the validation dataset, for OS and DFS. Gonen-Heller K indexes were 0.67 and 0.71, respectively.Conclusion: The HEI index proved to be a prognosticator in ASCC patients treated with CRT. Model dis-crimination in the external validation cohort was acceptable.(c) 2022 Elsevier B.V. All rights reserved. Radiotherapy and Oncology 177 (2022) 9-15

Published
2022

37. Clinical Outcomes and Toxicity of CT-guided High Dose-rate Brachytherapy in Women With Locally-advanced Cervical Cancer.

Author

SANCTIS, VITALIANA DE, FACONDO, GIUSEPPE, VULLO, GIANLUCA, ANZELLINI, DIMITRI, SANGUINETI, GIUSEPPE, NARDANGELI, ALESSIA, MARMIROLI, LUCA, TORTORETO, FRANCESCA, GENTILE, PIERCARLO, ANNESSI, IVAN, DONATO, VITTORIO, CHIOSTRINI, CINZIA, TOMBOLINI, VINCENZO, FELICE, FRANCESCA DE, VALERIANI, MAURIZIO, and OSTI, MATTIA FALCHETTO

Subjects
HIGH dose rate brachytherapy, CERVICAL cancer treatment, COMPUTED tomography, EXTERNAL beam radiotherapy, CLINICAL trials
Abstract

Background/Aim: To evaluate the outcome and toxicities in patients with locally advanced cervical cancer (LACC) treated with radiochemotherapy and intracavitary brachytherapy. Patients and Methods: This study included 67 patients with LACC treated between 2010 and 2018. The most represented stage was FIGO IIB. The patients were treated with external beam radiotherapy (EBRT) to the pelvis and boost to the cervix and parametrials. Concomitant chemotherapy (CHT) with cisplatin (CDDP) 40 mg/mq was planned. Subsequently, the patients underwent CT-based endouterine brachytherapy (BT). The response was evaluated at 3 months with PET-CT and/or pelvic magnetic resonance imaging (MRI). Since then, the patients have been followed with clinical instrumental controls every 4 months for the first 2 years and every 6 months for the following 3 years. Local response was assessed with pelvic MRI and/or PET-CT scan at the end of intracavitary BT) according to RECIST 1.1 criteria. Results: The median duration of treatment was 55 days (range=40-73 days). The prescription dose to the planning target volume (PTV) was delivered in 25 to 30 (median 28) daily fractions. The EBRT median dose to the pelvis and gross tumor volume were 50.4 Gy (range=45- 56.25) and 61.6 Gy (range=45-70.4), respectively. The 1- year, 2-year, 3-year, and 5-year overall survival rates were 92.44%, 80.81%, 78.84%, and 76.45% respectively. The actuarial 1-year, 2-year, 3-year, and 5-year disease-free survival rates were 89.5%, 83.6%, 81%, and 78.2% respectively. Conclusion: This study analyzed acute and chronic toxicity, survival, and local control in cervical cancer patients treated with IMRT followed by CT-planned high dose rate-brachytherapy. Patients demonstrated satisfactory outcomes and incidence of acute and late toxicities. [ABSTRACT FROM AUTHOR]

Published
2023
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41. 3137: RADIOABLATION FOR VENTRICULAR TACHYCARDIA: A COHORT MULTICENTER ANALYSIS OF EFFICACY AND HOMOGENEITY

Author

Cellini, Francesco, Narducci, Maria Lucia, Gentile, Piercarlo, Osti, Mattia Falchetto, Simoni, nicola, Fiorentino, Alba, Morganti, Alessio Giuseppe, Bianchi, Stefano, Miccichè, Francesco, Castelluccia, Alessandra, Bencardino, Gianluigi, Perna, francesco, Chiesa, Silvia, Massaccesi, Mariangela, Manfrida, Stefania, Bonaparte, I, Arcelli, alessandra, Priore, A, D’abbiero, Nunzia, Pavone, Chiara, Marchesano, Domenico, Valentini, Vincenzo, Crea, Filippo, Pelargonio, Gemma, and Gambacorta, Maria Antonietta

Published
2024
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43. Rectal cancer response to neoadjuvant chemoradiotherapy evaluated with MRI: Development and validation of a classification algorithm

Author

Rengo, Marco, primary, Landolfi, Federica, additional, Picchia, Simona, additional, Bellini, Davide, additional, Losquadro, Chiara, additional, Badia, Stefano, additional, Caruso, Damiano, additional, Iannicelli, Elsa, additional, Osti, Mattia Falchetto, additional, Tombolini, Vincenzo, additional, Carbone, Iacopo, additional, Giunta, Gaetano, additional, and Laghi, Andrea, additional

Published
2022
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47. Stereotactic and Hypofractionated Radiotherapy Associated With Immune Checkpoint Inhibitor Drugs: Analysis of Local Control, Toxicity, and Outcome in a Single Research Centre Case Study

Author

ANZELLINI, DIMITRI, primary, DE SANCTIS, VITALIANA, additional, VALERIANI, MAURIZIO, additional, REVERBERI, CHIARA, additional, MARINELLI, LUCA, additional, MASSARO, MARIA, additional, VULLO, GIANLUCA, additional, FACONDO, GIUSEPPE, additional, SIGILLO, RICCARDO CARLO, additional, TOSI, EMANUELE, additional, and OSTI, MATTIA FALCHETTO, additional

Published
2021
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49. HYPOFRACTIONATED RADIATION THERAPY (HFRT) OF BREAST/CHEST WALL AND REGIONAL NODES IN LOCALLY ADVANCED BREAST CANCER: TOXICITY PROFILE AND SURVIVAL OUTCOMES IN RETROSPECTIVE MONOISTITUTIONAL STUDY

Author

De Matteis, Sara, primary, Facondo, Giuseppe, additional, Valeriani, Maurizio, additional, Vullo, Gianluca, additional, De Sanctis, Vitaliana, additional, Ascolese, Anna Maria, additional, Campanella, Barbara, additional, Scalabrino, Giovanna, additional, and Osti, Mattia Falchetto, additional

Published
2021
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50. Adjuvant chemoradiotherapy in gastric cancer: a pooled analysis of the AIRO Gastrointestinal Group experience

Author

Mattiucci, Gian Carlo, Valentini, Chiara, DʼAgostino, Giuseppe Roberto, Augurio, Antonietta, Capirci, Carlo, De Paoli, Antonino, Genovesi, Domenico, Huscher, Alessandra, Iannone, Tiziana, Pani, Giuseppe, Rosetto, Maria Elena, Sciacero, Piera, Manfrida, Stefania, Corazzi, Francesca, Fusco, Vincenzo, Luppattelli, Marco, Mangiacotti, Maria Grazia, Melano, Antonella, Murino, Paola, Niespolo, Rita, Osti, Mattia Falchetto, Picardi, Vincenzo, Morganti, Alessio Giuseppe, and Valentini, Vincenzo

Published
2015
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