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5. The Outcome after Laser Therapy of Monochorionic Twin Pregnancies Complicated by Twin-Twin Transfusion Syndrome with Coexistent Selective Fetal Growth Restriction.

Author

Ortiz, Javier U., Guggenberger, Johanna, Graupner, Oliver, Ostermayer, Eva, Kuschel, Bettina, and Lobmaier, Silvia M.

Subjects
FETOFETAL transfusion, FETAL growth retardation, MULTIPLE pregnancy, MONOZYGOTIC twins, LASER therapy, PREGNANCY complications, FETOSCOPY
Abstract

Background: Most previous studies evaluated outcomes of twin–twin transfusion syndrome (TTTS) without considering the coexistence of selective fetal growth restriction (sFGR). The objectives of this study were to compare twin survival and pregnancy complications after laser therapy of TTTS with and without sFGR. Methods: For this purpose, a retrospective cohort study including 98 monochorionic diamniotic twins and three dichorionic triamniotic triplets treated in a single tertiary center was conducted. Results: Overall, 46 twins had selective fetal growth restriction (26 type I, 13 type II, 7 type III). At birth, donor survival (61% vs. 91%), double survival (57% vs. 82%), and overall survival (75% vs. 88%) were significantly lower in the group with coexistent sFGR. Recipient survival (89% vs. 86%), miscarriage (7% vs. 2%), PPROM < 32 weeks (48% vs. 29%), and preterm delivery < 32 weeks (52% vs. 45%) were not significantly higher in the group with coexistent sFGR. Donor twins with sFGR type I (69% vs. 91%) and types II–III (50% vs. 91%) showed significantly lower survival than those without sFGR. Multivariate regression analysis identified sFGR and its subtypes as independent predictors of donor demise. Conclusions: the coexistence of sFGR in TTTS pregnancies was associated with poor donor outcomes and is probably the most important predictor of donor survival. [ABSTRACT FROM AUTHOR]

Published
2024
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6. Application of the INTERGROWTH-21st chart compared to customized growth charts in fetuses with left heart obstruction: late trimester biometry, cerebroplacental hemodynamics and perinatal outcome

Author

Graupner, Oliver, Helfrich, Franziska, Ostermayer, Eva, Lobmaier, Silvia M., Ortiz, Javier U., Ewert, Peter, Wacker-Gussmann, Annette, Haller, Bernhard, Axt-Fliedner, Roland, Enzensberger, Christian, Abel, Kathrin, Karge, Anne, Oberhoffer, Renate, and Kuschel, Bettina

Published
2019
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10. 2 year neurodevelopmental and intermediate perinatal outcomes in infants with very preterm fetal growth restriction (TRUFFLE): a randomised trial

Author

Lees, Christoph C, Marlow, Neil, van Wassenaer-Leemhuis, Aleid, Arabin, Birgit, Bilardo, Caterina M, Brezinka, Christoph, Calvert, Sandra, Derks, Jan B, Diemert, Anke, Duvekot, Johannes J, Ferrazzi, Enrico, Frusca, Tiziana, Ganzevoort, Wessel, Hecher, Kurt, Martinelli, Pasquale, Ostermayer, Eva, Papageorghiou, Aris T, Schlembach, Dietmar, Schneider, K T M, Thilaganathan, Baskaran, Todros, Tullia, Valcamonico, Adriana, Visser, Gerard H A, and Wolf, Hans

Published
2015
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11. Perinatal and 2-year neurodevelopmental outcome in late preterm fetal compromise: the TRUFFLE 2 randomised trial protocol

Author

Mylrea-Foley, Bronacha, Thornton, Jim G, Mullins, Edward, Marlow, Neil, Hecher, Kurt, Ammari, Christina, Arabin, Birgit, Berger, Astrid, Bergman, Eva, Bhide, Amarnath, Bilardo, Caterina, Binder, Julia, Breeze, Andrew, Brodszki, Jana, Calda, Pavel, Cannings-John, Rebecca, Černý, Andrej, Cesari, Elena, Cetin, Irene, Dall'Asta, Andrea, Diemert, Anke, Ebbing, Cathrine, Eggebø, Torbjørn, Fantasia, Ilaria, Ferrazzi, Enrico, Frusca, Tiziana, Ghi, Tullio, Goodier, Jenny, Greimel, Patrick, Gyselaers, Wilfried, Hassan, Wassim, Von Kaisenberg, Constantin, Kholin, Alexey, Klaritsch, Philipp, Krofta, Ladislav, Lindgren, Peter, Lobmaier, Silvia, Marsal, Karel, Maruotti, Giuseppe M, Mecacci, Federico, Myklestad, Kirsti, Napolitano, Raffaele, Ostermayer, Eva, Papageorghiou, Aris, Potter, Claire, Prefumo, Federico, Raio, Luigi, Richter, Jute, Sande, Ragnar Kvie, Schlembach, Dietmar, Schleußner, Ekkehard, Stampalija, Tamara, Thilaganathan, Basky, Townson, Julia, Valensise, Herbert, Visser, Gerard Ha, Wee, Ling, Wolf, Hans, Lees, TRUFFLE 2 Collaborators List: Andrea Smith, Christoph C., Andrew, Sharp, Andy, Simm, Angela, Ramoni, Barry, Lloyd, Bianca, Masturzo, Christine, Morfeld, Christopher, Lloyd, Claudia, Seidig, Danielle, Thornton, Elena, Mantovani, Emanuela, Taricco, Bertucci, Emma, Erich, Cosmi, Eva, Ostermayer, Ferenc, Macsali, Ferrari, Francesca, Francesco, D'Antonio, Francesco, Picciotto, Gareth, Waring, Georgios, Rembouskos, Giuseppe, Cali, Giuseppe, Rizzo, Grazia Maria Tiralongo, Ilaria, Fantasia, Ilaria Giuditta Ramezzana, Ilenia, Mappa, Ioannis, Kyvernitakis, Iris, Derwig, Iris, Dressler-Steinbach, Jiří, Vojěch, Jørgen, Linde, Julia, Binder, Karen, Melchiorre, Kate, Walker, Kinga, Chalubinski, Kristiina, Rull, Kristina, Kernell, Lars, Brodowski, Laura, Sarno, Ligita, Jokibkiene, Liina, Rajasalu, Lina-Ana, Fryszer, Louisa, Jones, Magdalena, Bednarek-Jędrzejek, Makrina, Savvidou, Maria, Stefopoulou, Marianna, Rambaldi, Mark, Kilby, Nia, Jones, Nicola, Fratelli, Nishigandh, Deole, Patrick, Greimel, Petra, Pateisky, Pilar, Palmrich, Ralf, Schild, Roland, Devlieger, Sabina, Ondrová, Sarah, Gumpert, Sasha, Taylor, Saskia, Schmidt, Sebastian, Kwiatkowski, Serena, Caterina, Serena, Ottanelli, Serena, Simeone, Sergio, Ferrazzani, Silvia, Salvi, Silvia, Visentin, Sofia, Amylidi-Mohr, Spyros, Bakalis, Stefan, Verlohren, Susanne, Dargel, Sven, Kehl, Tanja, Groten, Tatjana, Radaelli, Tinne, Mesens, Tiziana, Fanelli, Torbjørn, Eggebø, Tullio, Ghi, Tuuli, Haabpiht, Wassim, Hassan, Yvonne, Heiman, Zulfiya, Khodzhaeva, Baskaran, Thilaganathan, Christoph, Brezinka, Sanne, Gordijn, Wessel, Ganzevoort, Abin Thomas Andrea Smith, Abin, Thomas, Mylrea-Foley, Bronacha, Thornton, Jim G, Mullins, Edward, Marlow, Neil, Hecher, Kurt, Ammari, Christina, Arabin, Birgit, Berger, Astrid, Bergman, Eva, Bhide, Amarnath, Bilardo, Caterina, Binder, Julia, Breeze, Andrew, Brodszki, Jana, Calda, Pavel, Cannings-John, Rebecca, Černý, Andrej, Cesari, Elena, Cetin, Irene, Dall'Asta, Andrea, Diemert, Anke, Ebbing, Cathrine, Eggebø, Torbjørn, Fantasia, Ilaria, Ferrazzi, Enrico, Frusca, Tiziana, Ghi, Tullio, Goodier, Jenny, Greimel, Patrick, Gyselaers, Wilfried, Hassan, Wassim, Von Kaisenberg, Constantin, Kholin, Alexey, Klaritsch, Philipp, Krofta, Ladislav, Lindgren, Peter, Lobmaier, Silvia, Marsal, Karel, Maruotti, Giuseppe M, Mecacci, Federico, Myklestad, Kirsti, Napolitano, Raffaele, Ostermayer, Eva, Papageorghiou, Ari, Potter, Claire, Prefumo, Federico, Raio, Luigi, Richter, Jute, Sande, Ragnar Kvie, Schlembach, Dietmar, Schleußner, Ekkehard, Stampalija, Tamara, Thilaganathan, Basky, Townson, Julia, Valensise, Herbert, Visser, Gerard Ha, Wee, Ling, Wolf, Han, Lees, Christoph C, Obstetrics and gynaecology, Amsterdam Reproduction & Development (AR&D), and National Institute for Health Research

Subjects
fetal medicine, Cardiotocography, PREDICTION, 610 Medicine & health, Reproduktionsmedicin och gynekologi, TRUFFLE 2 Collaborators List, Ultrasonography, Prenatal, 1117 Public Health and Health Services, Fetal, Medicine, General & Internal, AGE, Heart Rate, Pregnancy, Obstetrics, Gynecology and Reproductive Medicine, General & Internal Medicine, GROWTH RESTRICTION, Humans, Prenatal, Child, Randomized Controlled Trials as Topic, maternal medicine, Obstetrics and gynaecology, ultrasonography, Science & Technology, Fetal Growth Retardation, Infant, Newborn, Infant, 1103 Clinical Sciences, General Medicine, Heart Rate, Fetal, Newborn, ddc, DOPPLER, Fetal Weight, Settore MED/40, Female, Premature Birth, Life Sciences & Biomedicine, 1199 Other Medical and Health Sciences, Human
Abstract

IntroductionFollowing the detection of fetal growth restriction, there is no consensus about the criteria that should trigger delivery in the late preterm period. The consequences of inappropriate early or late delivery are potentially important yet practice varies widely around the world, with abnormal findings from fetal heart rate monitoring invariably leading to delivery. Indices derived from fetal cerebral Doppler examination may guide such decisions although there are few studies in this area. We propose a randomised, controlled trial to establish the optimum method of timing delivery between 32 weeks and 36 weeks 6 days of gestation. We hypothesise that delivery on evidence of cerebral blood flow redistribution reduces a composite of perinatal poor outcome, death and short-term hypoxia-related morbidity, with no worsening of neurodevelopmental outcome at 2 years.Methods and analysisWomen with non-anomalous singleton pregnancies 32+0 to 36+6 weeks of gestation in whom the estimated fetal weight or abdominal circumference is Ethics and disseminationThe Study Coordination Centre has obtained approval from London-Riverside Research Ethics Committee (REC) and Health Regulatory Authority (HRA). Publication will be in line with NIHR Open Access policy.Trial registration numberMain sponsor: Imperial College London, Reference: 19QC5491. Funders: NIHR HTA, Reference: 127 976. Study coordination centre: Imperial College Healthcare NHS Trust, Du Cane Road, London, W12 0HS with Centre for Trials Research, College of Biomedical & Life Sciences, Cardiff University. IRAS Project ID: 266 400. REC reference: 20/LO/0031. ISRCTN registry: 76 016 200.

Published
2022

16. Phase-rectified signal averaging method to predict perinatal outcome in infants with very preterm fetal growth restriction- a secondary analysis of TRUFFLE-trial

Author

Bilardo, Caterina M., Brezinka, Christoph, Diemert, Anke, Derks, Jan B., Schlembach, Dietmar, Todros, Tullia, Valcamonico, Adriana, Marlow, Neil, van Wassenaer-Leemhuis, Aleid, Lobmaier, Silvia M., Mensing van Charante, Nico, Ferrazzi, Enrico, Giussani, Dino A., Shaw, Caroline J., Müller, Alexander, Ortiz, Javier U., Ostermayer, Eva, Haller, Bernhard, Prefumo, Federico, Frusca, Tiziana, Hecher, Kurt, Arabin, Birgit, Thilaganathan, Baskaran, Papageorghiou, Aris T., Bhide, Amarnath, Martinelli, Pasquale, Duvekot, Johannes J., van Eyck, Jim, Visser, Gerard H.A., Schmidt, Georg, Ganzevoort, Wessel, Lees, Christoph C., and Schneider, Karl T.M.

Published
2016
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17. Fetal Cardiac Services during the COVID-19 Pandemic: How Does It Affect Parental Counseling?

Author

Kovacevic, Alexander, primary, Bär, Stefan, additional, Starystach, Sebastian, additional, Elsässer, Michael, additional, van der Locht, Thomas, additional, Mohammadi Motlagh, Aida, additional, Ostermayer, Eva, additional, Oberhoffer-Fritz, Renate, additional, Ewert, Peter, additional, Gorenflo, Matthias, additional, and Wacker-Gussmann, Annette, additional

Published
2021
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19. Parents’ Perspectives on Counseling for Fetal Heart Disease: What Matters Most?

Author

Kovacevic, Alexander;Wacker-Gussmann, Annette;Bär, Stefan;Elsässer, Michael;Mohammadi Motlagh, Aida;Ostermayer, Eva;Oberhoffer-Fritz, Renate;Ewert, Peter;Gorenflo, Matthias;Starystach, Sebastian and Kovacevic, Alexander;Wacker-Gussmann, Annette;Bär, Stefan;Elsässer, Michael;Mohammadi Motlagh, Aida;Ostermayer, Eva;Oberhoffer-Fritz, Renate;Ewert, Peter;Gorenflo, Matthias;Starystach, Sebastian

Published
2021

21. Diagnostic accuracy of random massively parallel sequencing for non-invasive prenatal detection of common autosomal aneuploidies: a collaborative study in Europe

Author

Stumm, Markus, Entezami, Michael, Haug, Karsten, Blank, Cornelia, Wüstemann, Max, Schulze, Bernt, Raabe-Meyer, Gisela, Hempel, Maja, Schelling, Markus, Ostermayer, Eva, Langer-Freitag, Sabine, Burkhardt, Tilo, Zimmermann, Roland, Schleicher, Tina, Weil, Bernd, Schöck, Ulrike, Smerdka, Patricia, Grömminger, Sebastian, Kumar, Yadhu, and Hofmann, Wera

Published
2014
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22. Comparative analysis of 2-year outcomes in GRIT and TRUFFLE trials

Author

Ganzevoort, W., Thornton, J. G., Marlow, N., Thilaganathan, B., Arabin, B., Prefumo, F., Lees, C., Wolf, H., Van Bulck, B, Kalakoutis, G M, Sak, P, Schneider, K T M, Karpathios, S E, Major, T, Todros, T, Arduini, D, Flumini, C, Tenore, A C, Roncaglia, N, Frusca, T, Ferretti, G, Weinans, M J N, Roosmalen, J, Slikke, J W, Geijn, H, Pernet, P J M, Wolf, H, Stigter, R H, Wilczynski, J, Vasco, E, Abdullah, M, Novak‐Antolic, Z, Danielian, P, Jenkinson, S D, Welch, C R, Griffin, C, Gee, H, Tuffnell, D, Cresswell, J, Tariq, T, Sengupta, B, Tydeman, G, Churchill, D, Bewley, S, Fusi, L, Lindow, S W, Johal, W, Fairlie, F M, Neales, K, Mason, G, Scudamore, I, Konje, J, Walkinshaw, S A, Griffiths, M, Dawson, A, Mires, G, Johanson, R, Fraser, R B, Ibbs, P Hendy, Steel, S A, Ramsay, M, Robins, J B, Heard, M J, Tonge, H M, Manyonda, I T, Walker, J, Maresh, M, Yoong, A, Soothill, P, Cameron, H, Byrne, D, Beattie, B, Bober, S, Van Damme, M, Kyriakides, S, Pokorna, P, Zimmerman, A, Tsitsikas, H, Mani, E, Bosisio, P, Mastritta, E, Nicocia, M, Fabris, C, Eken, P, De Vries, L, Kubicka, Z, Ramalho, R, Rashid, M, Cerar‐Kornhauser, L, Thomas, S, Elliman, A, Sim, T, Swaminathan, S, Walker, L, McCormick, D, Sibanda, Z, Hughes, J, Kilding, J, O'Hara, A, Harpin, V, Porter, N, Pandey, S, Murtagh, K, Burton, K, MacGregor, R, Stewart, B, Klenke, H, Hallam, P, Kai, N, Graham, M, Harrison, A, Saharia, E, McGhee, T, Rowsell, P, Howie, P, Parmar, Max, Field, D, Grant, A, Steer, P, Breart, G, Levene, M, Torgeson, D, Kitzinger, S, Marlowe, N, Wolke, Dieter, Johnson, A, Arabin, Birgit, Bilardo, Caterina M, Brezinka, Christoph, Cornette, Jerome M J, Derks, Jan B, Diemert, Anke, Duvekot, Johannes J, Ferrazzi, Enrico, Fratelli, Nicola, Frusca, Tiziana, Ganzevoort, Wessel, Hecher, Kurt, Leemhuis, Aleid, Lees, Christoph C, Lobmaier, Silvia, Marlow, Neil, Martinelli, Pasquale, Maso, Gianpaolo, Missfelder‐Lobos, Hannah, Napolitano, Raffaele, Ostermayer, Eva, Papageorghiou, Aris T, Prefumo, Federico, Schlembach, Dietmar, Thilaganathan, Baskaran, Todros, Tullia, Valcamonico, Adriana, Visser, Gerard H A, Wolf, Hans, Kingdom, John, Marsal, Karel, Thornton, Jim, Valensise, Herbert, Athena Institute, APH - Global Health, APH - Quality of Care, Obstetrics and gynaecology, Papageorghiou, AT, Obstetrics and Gynaecology, AR&D - Amsterdam Reproduction & Development, and APH - Digital Health

Subjects
short‐term variation, Technology, FLOW, INFANTS, cardiotocography, ductus venosus, fetal growth restriction, monitoring, short-term variation, Umbilical Arteries, Cohort Studies, 0302 clinical medicine, Obstetrics and gynaecology, Pregnancy, GROWTH RESTRICTION, Cardiotocography, 030212 general & internal medicine, Randomized Controlled Trials as Topic, Fetal Growth Retardation, 030219 obstetrics & reproductive medicine, Radiological and Ultrasound Technology, medicine.diagnostic_test, Obstetrics, Radiology, Nuclear Medicine & Medical Imaging, short term variation, Pregnancy Outcome, Obstetrics & Gynecology, Obstetrics and Gynecology, Gestational age, General Medicine, Original Papers, TRUFFLE Study Group, Settore MED/40, Pulsatile Flow, Gestation, Female, Life Sciences & Biomedicine, INTERVENTION, Blood Flow Velocity, Ductus venosus, Cohort study, medicine.medical_specialty, Birth weight, FETAL HEART-RATE, Ultrasonography, Prenatal, 03 medical and health sciences, SDG 3 - Good Health and Well-being, FETUSES, medicine, Humans, Radiology, Nuclear Medicine and imaging, Obstetrics & Reproductive Medicine, Fetal Death, GRIT Study Group, Original Paper, Fetus, Science & Technology, business.industry, Infant, Newborn, Acoustics, Reproductive Medicine, 1114 Paediatrics and Reproductive Medicine, business
Abstract

Objective To explore the effect on perinatal outcome of different fetal monitoring strategies for early‐onset fetal growth restriction (FGR). Methods This was a cohort analysis of individual participant data from two European multicenter trials of fetal monitoring methods for FGR: the Growth Restriction Intervention Study (GRIT) and the Trial of Umbilical and Fetal Flow in Europe (TRUFFLE). All women from GRIT (n = 238) and TRUFFLE (n = 503) who were randomized between 26 and 32 weeks' gestation were included. The women were grouped according to intervention and monitoring method: immediate delivery (GRIT) or delayed delivery with monitoring by conventional cardiotocography (CTG) (GRIT), computerized CTG (cCTG) only (GRIT and TRUFFLE) or cCTG and ductus venosus (DV) Doppler (TRUFFLE). The primary outcome was survival without neurodevelopmental impairment at 2 years of age. Results Gestational age at delivery and birth weight were similar in both studies. Fetal death rate was similar between the GRIT and TRUFFLE groups, but neonatal and late death were more frequent in GRIT (18% vs 6%; P, This article's abstract has been translated into Spanish and Chinese. Follow the links from the http://onlinelibrary.wiley.com/doi/10.1002/uog.20354/abstract to view the translations. This article has been selected for Journal Club. Click https://www.isuog.org/resource/uog-journal-club-January-2020.html to view slides and discussion points.

Published
2020

23. Fetal Cardiac Services during the COVID-19 Pandemic: How Does It Affect Parental Counseling?

Author

Kovacevic, Alexander;Bär, Stefan;Starystach, Sebastian;Elsässer, Michael;van der Locht, Thomas;Mohammadi Motlagh, Aida;Ostermayer, Eva;Oberhoffer-Fritz, Renate;Ewert, Peter;Gorenflo, Matthias;Wacker-Gussmann, Annette and Kovacevic, Alexander;Bär, Stefan;Starystach, Sebastian;Elsässer, Michael;van der Locht, Thomas;Mohammadi Motlagh, Aida;Ostermayer, Eva;Oberhoffer-Fritz, Renate;Ewert, Peter;Gorenflo, Matthias;Wacker-Gussmann, Annette

Published
2020

25. Objective Assessment of Counselling for Fetal Heart Defects: An Interdisciplinary Multicenter Study

Author

Kovacevic, Alexander, primary, Bär, Stefan, additional, Starystach, Sebastian, additional, Simmelbauer, Andreas, additional, Elsässer, Michael, additional, Müller, Andreas, additional, Mohammadi Motlagh, Aida, additional, Oberhoffer-Fritz, Renate, additional, Ostermayer, Eva, additional, Ewert, Peter, additional, Gorenflo, Matthias, additional, and Wacker-Gussmann, Annette, additional

Published
2020
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26. Objective Assessment of Counselling for Fetal Heart Defects: An Interdisciplinary Multicenter Study

Author

Kovacevic, Alexander;Bär, Stefan;Starystach, Sebastian;Simmelbauer, Andreas;Elsässer, Michael;Müller, Andreas;Mohammadi Motlagh, Aida;Oberhoffer-Fritz, Renate;Ostermayer, Eva;Ewert, Peter;Gorenflo, Matthias;Wacker-Gussmann, Annette and Kovacevic, Alexander;Bär, Stefan;Starystach, Sebastian;Simmelbauer, Andreas;Elsässer, Michael;Müller, Andreas;Mohammadi Motlagh, Aida;Oberhoffer-Fritz, Renate;Ostermayer, Eva;Ewert, Peter;Gorenflo, Matthias;Wacker-Gussmann, Annette

Published
2019

29. Application of the INTERGROWTH-21st chart compared to customized growth charts in fetuses with left heart obstruction: late trimester biometry, cerebroplacental hemodynamics and perinatal outcome

Author

Graupner, Oliver;Helfrich, Franziska;Ostermayer, Eva;Lobmaier, Silvia M.;Ortiz, Javier U.;Ewert, Peter;Wacker-Gussmann, Annette;Haller, Bernhard;Axt-Fliedner, Roland;Enzensberger, Christian;Abel, Kathrin;Karge, Anne;Oberhoffer, Renate;Kuschel, Bettina and Graupner, Oliver;Helfrich, Franziska;Ostermayer, Eva;Lobmaier, Silvia M.;Ortiz, Javier U.;Ewert, Peter;Wacker-Gussmann, Annette;Haller, Bernhard;Axt-Fliedner, Roland;Enzensberger, Christian;Abel, Kathrin;Karge, Anne;Oberhoffer, Renate;Kuschel, Bettina

Published
2018

30. Outcome in early-onset fetal growth restriction is best combining computerized fetal heart rate analysis with ductus venosus Doppler: insights from the Trial of Umbilical and Fetal Flow in Europe

Author

Frusca, Tiziana, primary, Todros, Tullia, additional, Lees, Christoph, additional, Bilardo, Caterina M., additional, Hecher, Kurt, additional, Visser, Gerard H.A., additional, Papageorghiou, Aris T., additional, Marlow, Neil, additional, Thilaganathan, Baskaran, additional, van Wassenaer-Leemhuis, Aleid, additional, Marsal, Karel, additional, Arabin, Birgit, additional, Brezinka, Christoph, additional, Derks, Jan B., additional, Diemert, Anke, additional, Duvekot, Johannes J., additional, Ferrazzi, Enrico, additional, Ganzevoort, J.W., additional, Martinelli, Pasquale, additional, Ostermayer, Eva, additional, Schlembach, Dietmar, additional, Valensise, Herbert, additional, Thornton, Jim, additional, and Wolf, Hans, additional

Published
2018
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31. Phase-rectified signal averaging method to predict perinatal outcome in infants with very preterm fetal growth restriction- a secondary analysis of TRUFFLE-trial

Author

Lobmaier, Silvia M., primary, Mensing van Charante, Nico, additional, Ferrazzi, Enrico, additional, Giussani, Dino A., additional, Shaw, Caroline J., additional, Müller, Alexander, additional, Ortiz, Javier U., additional, Ostermayer, Eva, additional, Haller, Bernhard, additional, Prefumo, Federico, additional, Frusca, Tiziana, additional, Hecher, Kurt, additional, Arabin, Birgit, additional, Thilaganathan, Baskaran, additional, Papageorghiou, Aris T., additional, Bhide, Amarnath, additional, Martinelli, Pasquale, additional, Duvekot, Johannes J., additional, van Eyck, Jim, additional, Visser, Gerard H.A., additional, Schmidt, Georg, additional, Ganzevoort, Wessel, additional, Lees, Christoph C., additional, Schneider, Karl T.M., additional, Bilardo, Caterina M., additional, Brezinka, Christoph, additional, Diemert, Anke, additional, Derks, Jan B., additional, Schlembach, Dietmar, additional, Todros, Tullia, additional, Valcamonico, Adriana, additional, Marlow, Neil, additional, and van Wassenaer-Leemhuis, Aleid, additional

Published
2016
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32. Phase-rectified signal averaging method to predict perinatal outcome in infants with very preterm fetal growth restriction- a secondary analysis of TRUFFLE-trial

Author

Lobmaier, Silvia M., Mensing van Charante, Nico, Ferrazzi, Enrico, Giussani, Dino A., Shaw, Caroline J., Müller, Alexander, Ortiz, Javier U., Ostermayer, Eva, Haller, Bernhard, Prefumo, Federico, Frusca, Tiziana, Hecher, Kurt, Arabin, Birgit, Thilaganathan, Baskaran, Papageorghiou, Aris T., Bhide, Amarnath, Martinelli, Pasquale, Duvekot, Johannes J., van Eyck, Jim, Visser, Gerard H A, Schmidt, Georg, Ganzevoort, Wessel, Lees, Christoph C., Schneider, Karl T M, Bilardo, Caterina M., Brezinka, Christoph, Diemert, Anke, Derks, Jan B., Schlembach, Dietmar, Todros, Tullia, Valcamonico, Adriana, Marlow, Neil, van Wassenaer-Leemhuis, Aleid, Lobmaier, Silvia M., Mensing van Charante, Nico, Ferrazzi, Enrico, Giussani, Dino A., Shaw, Caroline J., Müller, Alexander, Ortiz, Javier U., Ostermayer, Eva, Haller, Bernhard, Prefumo, Federico, Frusca, Tiziana, Hecher, Kurt, Arabin, Birgit, Thilaganathan, Baskaran, Papageorghiou, Aris T., Bhide, Amarnath, Martinelli, Pasquale, Duvekot, Johannes J., van Eyck, Jim, Visser, Gerard H A, Schmidt, Georg, Ganzevoort, Wessel, Lees, Christoph C., Schneider, Karl T M, Bilardo, Caterina M., Brezinka, Christoph, Diemert, Anke, Derks, Jan B., Schlembach, Dietmar, Todros, Tullia, Valcamonico, Adriana, Marlow, Neil, and van Wassenaer-Leemhuis, Aleid

Published
2016

33. Phase-rectified signal averaging method to predict perinatal outcome in infants with very preterm fetal growth restriction- a secondary analysis of TRUFFLE-trial

Author

MS Verloskunde, Other research (not in main researchprogram), Lobmaier, Silvia M., Mensing van Charante, Nico, Ferrazzi, Enrico, Giussani, Dino A., Shaw, Caroline J., Müller, Alexander, Ortiz, Javier U., Ostermayer, Eva, Haller, Bernhard, Prefumo, Federico, Frusca, Tiziana, Hecher, Kurt, Arabin, Birgit, Thilaganathan, Baskaran, Papageorghiou, Aris T., Bhide, Amarnath, Martinelli, Pasquale, Duvekot, Johannes J., van Eyck, Jim, Visser, Gerard H A, Schmidt, Georg, Ganzevoort, Wessel, Lees, Christoph C., Schneider, Karl T M, Bilardo, Caterina M., Brezinka, Christoph, Diemert, Anke, Derks, Jan B., Schlembach, Dietmar, Todros, Tullia, Valcamonico, Adriana, Marlow, Neil, van Wassenaer-Leemhuis, Aleid, MS Verloskunde, Other research (not in main researchprogram), Lobmaier, Silvia M., Mensing van Charante, Nico, Ferrazzi, Enrico, Giussani, Dino A., Shaw, Caroline J., Müller, Alexander, Ortiz, Javier U., Ostermayer, Eva, Haller, Bernhard, Prefumo, Federico, Frusca, Tiziana, Hecher, Kurt, Arabin, Birgit, Thilaganathan, Baskaran, Papageorghiou, Aris T., Bhide, Amarnath, Martinelli, Pasquale, Duvekot, Johannes J., van Eyck, Jim, Visser, Gerard H A, Schmidt, Georg, Ganzevoort, Wessel, Lees, Christoph C., Schneider, Karl T M, Bilardo, Caterina M., Brezinka, Christoph, Diemert, Anke, Derks, Jan B., Schlembach, Dietmar, Todros, Tullia, Valcamonico, Adriana, Marlow, Neil, and van Wassenaer-Leemhuis, Aleid

Published
2016

34. 2 year neurodevelopmental and intermediate perinatal outcomes in infants with very preterm fetal growth restriction (TRUFFLE) : A randomised trial

Author

Lees, Christoph C., Marlow, Neil, Van Wassenaer-Leemhuis, Aleid, Arabin, Birgit, Bilardo, Caterina M., Brezinka, Christoph, Calvert, Sandra, Derks, Jan B., Diemert, Anke, Duvekot, Johannes J., Ferrazzi, Enrico, Frusca, Tiziana, Ganzevoort, Wessel, Hecher, Kurt, Martinelli, Pasquale, Ostermayer, Eva, Papageorghiou, Aris T., Schlembach, Dietmar, Schneider, K. T M, Thilaganathan, Baskaran, Todros, Tullia, Valcamonico, Adriana, Visser, Gerard H A, Wolf, Hans, Aktas, Ayse, Borgione, Silvia, Chaoui, Rabih, Cornette, Jerome M J, Diehl, Thilo, Van Eyck, Jim, Fratelli, Nicola, Van Haastert, Inge Lot, Lobmaier, Silvia, Lopriore, Enrico, Missfelder-Lobos, Hannah, Mansi, Giuseppina, Martelli, Paola, Maso, Gianpaolo, Maurer-Fellbaum, Ute, Van Charante, Nico Mensing, De Tollenaer, Susanne Mulder, Napolitano, Raffaele, Oberto, Manuela, Oepkes, Dick, Ogge, Giovanna, Van Der Post, Joris, Prefumo, Federico, Preston, Lucy, Raimondi, Francesco, Reiss, Irwin K M, Scheepers, H. C J, Schuit, Ewoud, Skabar, Aldo, Spaanderman, Marc, Weisglas-Kuperus, Nynke, Zimmermann, Andrea, Moore, Tamanna, Johnson, Samantha, Rigano, Serena, Lees, Christoph C., Marlow, Neil, Van Wassenaer-Leemhuis, Aleid, Arabin, Birgit, Bilardo, Caterina M., Brezinka, Christoph, Calvert, Sandra, Derks, Jan B., Diemert, Anke, Duvekot, Johannes J., Ferrazzi, Enrico, Frusca, Tiziana, Ganzevoort, Wessel, Hecher, Kurt, Martinelli, Pasquale, Ostermayer, Eva, Papageorghiou, Aris T., Schlembach, Dietmar, Schneider, K. T M, Thilaganathan, Baskaran, Todros, Tullia, Valcamonico, Adriana, Visser, Gerard H A, Wolf, Hans, Aktas, Ayse, Borgione, Silvia, Chaoui, Rabih, Cornette, Jerome M J, Diehl, Thilo, Van Eyck, Jim, Fratelli, Nicola, Van Haastert, Inge Lot, Lobmaier, Silvia, Lopriore, Enrico, Missfelder-Lobos, Hannah, Mansi, Giuseppina, Martelli, Paola, Maso, Gianpaolo, Maurer-Fellbaum, Ute, Van Charante, Nico Mensing, De Tollenaer, Susanne Mulder, Napolitano, Raffaele, Oberto, Manuela, Oepkes, Dick, Ogge, Giovanna, Van Der Post, Joris, Prefumo, Federico, Preston, Lucy, Raimondi, Francesco, Reiss, Irwin K M, Scheepers, H. C J, Schuit, Ewoud, Skabar, Aldo, Spaanderman, Marc, Weisglas-Kuperus, Nynke, Zimmermann, Andrea, Moore, Tamanna, Johnson, Samantha, and Rigano, Serena

Published
2015

35. 2 year neurodevelopmental and intermediate perinatal outcomes in infants with very preterm fetal growth restriction (TRUFFLE): A randomised trial

Author

MS Verloskunde, Other research (not in main researchprogram), UMC Utrecht, Brain, Epi Methoden Team 1, Lees, Christoph C., Marlow, Neil, Van Wassenaer-Leemhuis, Aleid, Arabin, Birgit, Bilardo, Caterina M., Brezinka, Christoph, Calvert, Sandra, Derks, Jan B., Diemert, Anke, Duvekot, Johannes J., Ferrazzi, Enrico, Frusca, Tiziana, Ganzevoort, Wessel, Hecher, Kurt, Martinelli, Pasquale, Ostermayer, Eva, Papageorghiou, Aris T., Schlembach, Dietmar, Schneider, K. T M, Thilaganathan, Baskaran, Todros, Tullia, Valcamonico, Adriana, Visser, Gerard H A, Wolf, Hans, Aktas, Ayse, Borgione, Silvia, Chaoui, Rabih, Cornette, Jerome M J, Diehl, Thilo, Van Eyck, Jim, Fratelli, Nicola, Van Haastert, Inge Lot, Lobmaier, Silvia, Lopriore, Enrico, Missfelder-Lobos, Hannah, Mansi, Giuseppina, Martelli, Paola, Maso, Gianpaolo, Maurer-Fellbaum, Ute, Van Charante, Nico Mensing, De Tollenaer, Susanne Mulder, Napolitano, Raffaele, Oberto, Manuela, Oepkes, Dick, Ogge, Giovanna, Van Der Post, Joris, Prefumo, Federico, Preston, Lucy, Raimondi, Francesco, Reiss, Irwin K M, Scheepers, H. C J, Schuit, Ewoud, Skabar, Aldo, Spaanderman, Marc, Weisglas-Kuperus, Nynke, Zimmermann, Andrea, Moore, Tamanna, Johnson, Samantha, Rigano, Serena, MS Verloskunde, Other research (not in main researchprogram), UMC Utrecht, Brain, Epi Methoden Team 1, Lees, Christoph C., Marlow, Neil, Van Wassenaer-Leemhuis, Aleid, Arabin, Birgit, Bilardo, Caterina M., Brezinka, Christoph, Calvert, Sandra, Derks, Jan B., Diemert, Anke, Duvekot, Johannes J., Ferrazzi, Enrico, Frusca, Tiziana, Ganzevoort, Wessel, Hecher, Kurt, Martinelli, Pasquale, Ostermayer, Eva, Papageorghiou, Aris T., Schlembach, Dietmar, Schneider, K. T M, Thilaganathan, Baskaran, Todros, Tullia, Valcamonico, Adriana, Visser, Gerard H A, Wolf, Hans, Aktas, Ayse, Borgione, Silvia, Chaoui, Rabih, Cornette, Jerome M J, Diehl, Thilo, Van Eyck, Jim, Fratelli, Nicola, Van Haastert, Inge Lot, Lobmaier, Silvia, Lopriore, Enrico, Missfelder-Lobos, Hannah, Mansi, Giuseppina, Martelli, Paola, Maso, Gianpaolo, Maurer-Fellbaum, Ute, Van Charante, Nico Mensing, De Tollenaer, Susanne Mulder, Napolitano, Raffaele, Oberto, Manuela, Oepkes, Dick, Ogge, Giovanna, Van Der Post, Joris, Prefumo, Federico, Preston, Lucy, Raimondi, Francesco, Reiss, Irwin K M, Scheepers, H. C J, Schuit, Ewoud, Skabar, Aldo, Spaanderman, Marc, Weisglas-Kuperus, Nynke, Zimmermann, Andrea, Moore, Tamanna, Johnson, Samantha, and Rigano, Serena

Published
2015

36. 2 Year Neurodevelopmental and Intermediate Perinatal Outcomes in Infants With Very Preterm Fetal Growth Restriction (TRUFFLE)

Author

Lees, Christoph C., primary, Marlow, Neil, additional, van Wassenaer-Leemhuis, Aleid, additional, Arabin, Birgit, additional, Bilardo, Caterina M., additional, Brezinka, Christoph, additional, Calvert, Sandra, additional, Derks, Jan B., additional, Diemert, Anke, additional, Duvekot, Johannes J., additional, Ferrazzi, Enrico, additional, Frusca, Tiziana, additional, Ganzevoort, Wessel, additional, Hecher, Kurt, additional, Martinelli, Pasquale, additional, Ostermayer, Eva, additional, Papageorghiou, Aris T., additional, Schlembach, Dietmar, additional, Schneider, K. T. M., additional, Thilaganathan, Baskaran, additional, Todros, Tullia, additional, Valcamonico, Adriana, additional, Visser, Gerard H. A., additional, and Wolf, Hans, additional

Published
2015
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37. Diagnostic accuracy of random massively parallel sequencing for non-invasive prenatal detection of common autosomal aneuploidies: a collaborative study in Europe

Author

Stumm, Markus, primary, Entezami, Michael, additional, Haug, Karsten, additional, Blank, Cornelia, additional, Wüstemann, Max, additional, Schulze, Bernt, additional, Raabe-Meyer, Gisela, additional, Hempel, Maja, additional, Schelling, Markus, additional, Ostermayer, Eva, additional, Langer-Freitag, Sabine, additional, Burkhardt, Tilo, additional, Zimmermann, Roland, additional, Schleicher, Tina, additional, Weil, Bernd, additional, Schöck, Ulrike, additional, Smerdka, Patricia, additional, Grömminger, Sebastian, additional, Kumar, Yadhu, additional, and Hofmann, Wera, additional

Published
2013
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38. The role of genetics in fetal bradycardia.

Author

Westphal, Dominik, Shoukier, Mouneef, Zuther, Ines, Schramm, Thomas, Hauser, Michael, Ostermayer, Eva, Hessling, Gabriele, Fritz, Renate Oberhoffer, and Gussmann, Annette Wacker

Published
2022

47. Prognostic Value of Cerebroplacental Ratio in Appropriate-for-Gestational-Age Fetuses Before Induction of Labor in Late-Term Pregnancies.

Author

Ortiz JU, Graupner O, Flechsenhar S, Karge A, Ostermayer E, Abel K, Kuschel B, and Lobmaier SM

Subjects
Infant, Newborn, Pregnancy, Female, Humans, Prognosis, Retrospective Studies, Fetal Distress, Prospective Studies, Fetus, Umbilical Arteries diagnostic imaging, Ultrasonography, Prenatal, Pulsatile Flow, Labor, Induced, Pregnancy Outcome, Cesarean Section
Abstract

Purpose:  To evaluate the relationship between cerebroplacental ratio (CPR) and the need for operative delivery due to intrapartum fetal compromise (IFC) and adverse perinatal outcome (APO) in appropriate-for-gestational-age (AGA) late-term pregnancies undergoing induction of labor. The predictive performance of CPR was also assessed., Materials and Methods:  Retrospective study including singleton AGA pregnancies that underwent elective induction of labor between 41 + 0 and 41 + 6 weeks and were delivered before 42 + 0 weeks. IFC was defined as persistent pathological CTG or pathological CTG and fetal scalp pH < 7.20. Operative delivery included instrumental vaginal delivery (IVD) and cesarean section (CS). APO was defined as a composite of umbilical artery pH < 7.20, Apgar score < 7 at 5 minutes, and admission to the neonatal intensive care unit for > 24 hours., Results:  The study included 314 women with 32 (10 %) IVDs and 49 (16 %) CSs due to IFC and 85 (27 %) APO cases. Fetuses with CPR < 10 th percentile showed a significantly higher rate of operative delivery for IFC (40 % (21/52) vs. 23 % (60/262); p = 0.008) yet not a significantly higher rate of APO (31 % (16/52) vs. 26 % (69/262); p = 0.511). The predictive values of CPR for operative delivery due to IFC and APO showed sensitivities of 26 % and 19 %, specificities of 87 % and 84 %, positive LRs of 2.0 and 1.2, and negative LRs of 0.85 and 0.96, respectively., Conclusion:  Low CPR in AGA late-term pregnancies undergoing elective induction of labor was associated with a higher risk of operative delivery for IFC without increasing the APO rate. However, the predictive value of CPR was poor., Competing Interests: The authors declare that they have no conflict of interest., (Thieme. All rights reserved.)

Published
2023
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48. Perinatal and 2-year neurodevelopmental outcome in late preterm fetal compromise: the TRUFFLE 2 randomised trial protocol.

Author

Mylrea-Foley B, Thornton JG, Mullins E, Marlow N, Hecher K, Ammari C, Arabin B, Berger A, Bergman E, Bhide A, Bilardo C, Binder J, Breeze A, Brodszki J, Calda P, Cannings-John R, Černý A, Cesari E, Cetin I, Dall'Asta A, Diemert A, Ebbing C, Eggebø T, Fantasia I, Ferrazzi E, Frusca T, Ghi T, Goodier J, Greimel P, Gyselaers W, Hassan W, Von Kaisenberg C, Kholin A, Klaritsch P, Krofta L, Lindgren P, Lobmaier S, Marsal K, Maruotti GM, Mecacci F, Myklestad K, Napolitano R, Ostermayer E, Papageorghiou A, Potter C, Prefumo F, Raio L, Richter J, Sande RK, Schlembach D, Schleußner E, Stampalija T, Thilaganathan B, Townson J, Valensise H, Visser GH, Wee L, Wolf H, and Lees CC

Subjects
Cardiotocography, Child, Female, Fetal Growth Retardation, Fetal Weight, Heart Rate, Fetal physiology, Humans, Infant, Infant, Newborn, Pregnancy, Randomized Controlled Trials as Topic, Premature Birth, Ultrasonography, Prenatal
Abstract

Introduction: Following the detection of fetal growth restriction, there is no consensus about the criteria that should trigger delivery in the late preterm period. The consequences of inappropriate early or late delivery are potentially important yet practice varies widely around the world, with abnormal findings from fetal heart rate monitoring invariably leading to delivery. Indices derived from fetal cerebral Doppler examination may guide such decisions although there are few studies in this area. We propose a randomised, controlled trial to establish the optimum method of timing delivery between 32 weeks and 36 weeks 6 days of gestation. We hypothesise that delivery on evidence of cerebral blood flow redistribution reduces a composite of perinatal poor outcome, death and short-term hypoxia-related morbidity, with no worsening of neurodevelopmental outcome at 2 years., Methods and Analysis: Women with non-anomalous singleton pregnancies 32+0 to 36+6 weeks of gestation in whom the estimated fetal weight or abdominal circumference is <10th percentile or has decreased by 50 percentiles since 18-32 weeks will be included for observational data collection. Participants will be randomised if cerebral blood flow redistribution is identified, based on umbilical to middle cerebral artery pulsatility index ratio values. Computerised cardiotocography (cCTG) must show normal fetal heart rate short term variation (≥4.5 msec) and absence of decelerations at randomisation. Randomisation will be 1:1 to immediate delivery or delayed delivery (based on cCTG abnormalities or other worsening fetal condition). The primary outcome is poor condition at birth and/or fetal or neonatal death and/or major neonatal morbidity, the secondary non-inferiority outcome is 2-year infant general health and neurodevelopmental outcome based on the Parent Report of Children's Abilities-Revised questionnaire., Ethics and Dissemination: The Study Coordination Centre has obtained approval from London-Riverside Research Ethics Committee (REC) and Health Regulatory Authority (HRA). Publication will be in line with NIHR Open Access policy., Trial Registration Number: Main sponsor: Imperial College London, Reference: 19QC5491. Funders: NIHR HTA, Reference: 127 976. Study coordination centre: Imperial College Healthcare NHS Trust, Du Cane Road, London, W12 0HS with Centre for Trials Research, College of Biomedical & Life Sciences, Cardiff University. IRAS Project ID: 266 400. REC reference: 20/LO/0031. ISRCTN registry: 76 016 200., Competing Interests: Competing interests: All authors have completed the ICMJE uniform disclosure form at www.icmje.org/coidisclosure.pdfanddeclare: no financial relationships with any organisations that might have an interest in the submitted work in the previous 3 years; no other relationships or activities that could appear to have influenced the submitted work., (© Author(s) (or their employer(s)) 2022. Re-use permitted under CC BY. Published by BMJ.)

Published
2022
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