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Your search keyword '"Osteointegration oxidative stress"' showing total 2 results
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2 results on '"Osteointegration oxidative stress"'

1. The performance of a scaffold bioglass-chitosan in the treatment of bone defect.

Author

Boulila, Salha, Oudadesse, Hassane, Kallel, Rim, Ghrab, Ferdaws, Lefeuvre, Bertrand, Boudawara, Tahia, Elfeki, Abdelfattah, and Elfeki, Hafed

Subjects
*BONE abnormalities, *CHITOSAN, *OSSEOINTEGRATION, *CIPROFLOXACIN, *TISSUE scaffolds
Abstract

The present research work is an in vivo study that aimed to evaluate the potential role of bioglass-chitosan (BG-CS) and bioglass-chitosan-20%ciprofloxacin (BG-CS-20Cip) in antioxidant profile and osteointegration. These scaffolds were implanted in the defect bone of femoral condyles in ovariectomized rats. The treatment with BG-CS-20Cip has shown a significantly higher stress proteins concentration in comparison with that implanted with BG-CS group. The thiol and vitamin C in BG-CS-20Cip group were significantly enhanced when compared with those in BG-CS group. The histological and physicochemical analyses highlight the BG-CS implications in the bone construction. This property was found to decrease with the presence of ciprofloxacin that caused the delay of this phenomenon. ICP-OES has revealed that the introduction of this antibiotic to the composite led to decrease bone mineralization by evaluating Ca/P ratio. The SEM results have confirmed a progressive degradation of BG-CS and BG-CS-20Cip. However, such bioresorbability and bioactivity of BG-CS was proven to be faster than those of BG-CS-20Cip. Therefore, the incorporation of ciprofloxacin in BG-CS was characterized by a delaying effect of composite dissolution and the formation of apatitic phase. The development of BG-CS as a therapeutic biomaterial protector against oxidative stress is likely to make an effective choice for the application in tissue engineering. [ABSTRACT FROM AUTHOR]

Published
2018
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2. The performance of a scaffold bioglass-chitosan in the treatment of bone defect

Author

Hafed Elfeki, Hassane Oudadesse, Ferdaws Ghrab, Bertrand Lefeuvre, Rim Kallel, Tahia Boudawara, Abdelfattah Elfeki, Salha Boulila, Institut des Sciences Chimiques de Rennes (ISCR), Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie du CNRS (INC)-Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Ecole Nationale Supérieure de Chimie de Rennes (ENSCR)-Institut National des Sciences Appliquées - Rennes (INSA Rennes), Institut National des Sciences Appliquées (INSA)-Université de Rennes (UNIV-RENNES)-Institut National des Sciences Appliquées (INSA), Université de Sfax - University of Sfax, Tunisian Ministry of Higher Education and Scientific Research, Tunisian Ministry of Public Health, University of Rennes 1, CNRS France, Université de Rennes (UR)-Institut National des Sciences Appliquées - Rennes (INSA Rennes), and Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Ecole Nationale Supérieure de Chimie de Rennes (ENSCR)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)

Subjects
0301 basic medicine, Antioxidant, Polymers and Plastics, medicine.medical_treatment, 02 engineering and technology, medicine.disease_cause, Bioactivity, Osseointegration, Chitosan, 03 medical and health sciences, chemistry.chemical_compound, Tissue engineering, In vivo, Ciprofloxacin, Materials Chemistry, medicine, [CHIM]Chemical Sciences, Osteointegration oxidative stress, Biomaterial, Bioglass, General Chemistry, 021001 nanoscience & nanotechnology, Condensed Matter Physics, 030104 developmental biology, chemistry, Ovariectomized rat, 0210 nano-technology, Oxidative stress, Biomedical engineering
Abstract

International audience; The present research work is an in vivo study that aimed to evaluate the potential role of bioglass-chitosan (BG-CS) and bioglass-chitosan-20%ciprofloxacin (BG-CS-20Cip) in antioxidant profile and osteointegration. These scaffolds were implanted in the defect bone of femoral condyles in ovariectomized rats. The treatment with BG-CS-20Cip has shown a significantly higher stress proteins concentration in comparison with that implanted with BG-CS group. The thiol and vitamin C in BG-CS-20Cip group were significantly enhanced when compared with those in BG-CS group. The histological and physicochemical analyses highlight the BG-CS implications in the bone construction. This property was found to decrease with the presence of ciprofloxacin that caused the delay of this phenomenon. ICP-OES has revealed that the introduction of this antibiotic to the composite led to decrease bone mineralization by evaluating Ca/P ratio. The SEM results have confirmed a progressive degradation of BG-CS and BG-CS-20Cip. However, such bioresorbability and bioactivity of BG-CS was proven to be faster than those of BG-CS-20Cip. Therefore, the incorporation of ciprofloxacin in BG-CS was characterized by a delaying effect of composite dissolution and the formation of apatitic phase. The development of BG-CS as a therapeutic biomaterial protector against oxidative stress is likely to make an effective choice for the application in tissue engineering.

Published
2018
Full Text
View/download PDF

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