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21 results on '"Oshiro, Aya"'

4. Supplementary Data from Age-Related EBV-Associated B-Cell Lymphoproliferative Disorders Constitute a Distinct Clinicopathologic Group: A Study of 96 Patients

Author

Oyama, Takashi, primary, Yamamoto, Kazuhito, primary, Asano, Naoko, primary, Oshiro, Aya, primary, Suzuki, Ritsuro, primary, Kagami, Yoshitoyo, primary, Morishima, Yasuo, primary, Takeuchi, Kengo, primary, Izumo, Toshiyuki, primary, Mori, Shigeo, primary, Ohshima, Koichi, primary, Suzumiya, Junji, primary, Nakamura, Naoya, primary, Abe, Masafumi, primary, Ichimura, Koichi, primary, Sato, Yumiko, primary, Yoshino, Tadashi, primary, Naoe, Tomoki, primary, Shimoyama, Yoshie, primary, Kamiya, Yoshikazu, primary, Kinoshita, Tomohiro, primary, and Nakamura, Shigeo, primary

Published
2023
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5. Cytological characteristics of premalignant cervical epithelial lesions in postmenopausal women based on endocrine indices and parakeratosis

Author

Sugisawa, Akiyuki, primary, Toyoda, Zensei, additional, Tanabe, Yasuka, additional, Uehara, Karina, additional, Oshiro, Aya, additional, Yamazato, Reo, additional, Sakamoto, Chiharu, additional, Yogi, Shohei, additional, Kurima, Kiyoto, additional, Kina, Shinichiro, additional, Sakiyama, Michiyo, additional, and Kinjo, Takao, additional

Published
2022
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11. Phase II study of a salvage regimen using cyclophosphamide, high‐dose cytarabine, dexamethasone, etoposide, and rituximab in patients with relapsed or refractory B‐cell non‐Hodgkin's lymphoma

Author

Oki, Yasuhiro, primary, Ogura, Michinori, additional, Kato, Harumi, additional, Kikuchi, Ako, additional, Taji, Hirofumi, additional, Kagami, Yoshitoyo, additional, Oshiro, Aya, additional, Tsujimura, Akane, additional, Yamamoto, Kazuhito, additional, and Morishima, Yasuo, additional

Published
2007
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12. Age-Related EBV-Associated B-Cell Lymphoproliferative Disorders Constitute a Distinct Clinicopathologic Group: A Study of 96 Patients

Author

Oyama, Takashi, primary, Yamamoto, Kazuhito, additional, Asano, Naoko, additional, Oshiro, Aya, additional, Suzuki, Ritsuro, additional, Kagami, Yoshitoyo, additional, Morishima, Yasuo, additional, Takeuchi, Kengo, additional, Izumo, Toshiyuki, additional, Mori, Shigeo, additional, Ohshima, Koichi, additional, Suzumiya, Junji, additional, Nakamura, Naoya, additional, Abe, Masafumi, additional, Ichimura, Koichi, additional, Sato, Yumiko, additional, Yoshino, Tadashi, additional, Naoe, Tomoki, additional, Shimoyama, Yoshie, additional, Kamiya, Yoshikazu, additional, Kinoshita, Tomohiro, additional, and Nakamura, Shigeo, additional

Published
2007
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17. Signet-Ring Cell Lymphoma

Author

NAGASAKI, Akitoshi, primary, OSHIRO, Aya, additional, MIYAGI, Takashi, additional, SAKIHARA, Michiyo, additional, OSHIMA, Koichi, additional, KIKUCHI, Masahiro, additional, OKUDAIRA, Taeko, additional, NAKAZATO, Tetsuro, additional, SHINJO, Tetsuharu, additional, TAIRA, Naoya, additional, TAKASU, Nobuyuki, additional, and MASUDA, Masato, additional

Published
2003
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18. Identification of subtype-specific genomic alterations in aggressive adult T-cell leukemia/lymphoma

Author

Oshiro, Aya, Tagawa, Hiroyuki, Ohshima, Koichi, Karube, Kennosuke, Uike, Naokuni, Tashiro, Yukie, Utsunomiya, Atae, Masuda, Masato, Takasu, Nobuyuki, Nakamura, Shigeo, Morishima, Yasuo, and Seto, Masao

Abstract

Aggressive adult T-cell leukemia/lymphoma (ATLL) such as acute and lymphoma types are fatal diseases with poor prognosis. Although these 2 subtypes feature different clinicopathologic characteristics, no detailed comparative analyses of genomic/genetic alterations have been reported. We performed array-based comparative genomic hybridization for 17 acute and 49 lymphoma cases as well as real-time quantitative polymerase chain reaction (PCR) to identify the target genes of recurrently amplified regions. Comparison of the genome profiles of acute and lymphoma types revealed that the lymphoma type had significantly more frequent gains at 1q, 2p, 4q, 7p, and 7q, and losses of 10p, 13q, 16q, and 18p, whereas the acute type showed a gain of 3/3p. Of the recurrent high-level amplifications found at 1p36, 6p25, 7p22, 7q, and 14q32 in the lymphoma type, we were able to demonstrate that CARMA1is a possible target gene of the 7p22 amplification for the lymphoma type but not for the acute type. Furthermore, we found BCL11Boverexpression in the acute type regardless of the 14q32 gain/amplification, but no or low expression of the gene in the lymphoma type. These results suggest that acute and lymphoma types are genomically distinct subtypes, and thus may develop tumors via distinct genetic pathways.

Published
2006
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19. Array comparative genomic hybridization analysis of PTCL-U reveals a distinct subgroup with genetic alterations similar to lymphoma-type adult T-cell leukemia/lymphoma.

Author

Nakagawa M, Nakagawa-Oshiro A, Karnan S, Tagawa H, Utsunomiya A, Nakamura S, Takeuchi I, Ohshima K, and Seto M

Subjects
Adult, Comparative Genomic Hybridization, Female, Humans, Leukemia-Lymphoma, Adult T-Cell diagnosis, Leukemia-Lymphoma, Adult T-Cell pathology, Lymphoma, T-Cell, Peripheral diagnosis, Lymphoma, T-Cell, Peripheral pathology, Male, Middle Aged, Oligonucleotide Array Sequence Analysis, Prognosis, Chromosome Aberrations, Leukemia-Lymphoma, Adult T-Cell genetics, Lymphoma, T-Cell, Peripheral genetics
Abstract

Purpose: Peripheral T-cell lymphoma, unspecified (PTCL-U) comprises histopathologically and clinically heterogeneous groups. The purpose of this study was to identify subgroups with distinct genetic, histopathologic, and prognostic features., Experimental Design: We used array comparative genomic hybridization (CGH) for high-resolution analysis of 51 PTCL-U patients and the array data for examining possible correlations of histopathologic and clinical features. Moreover, we compared the genetic, histopathologic, and prognostic features of the PTCL-U cases with those of 59 cases of lymphoma-type adult T-cell leukemia/lymphoma (ATLL)., Results: We identified 32 regions with frequent genomic imbalance, 1 region with high copy number gain at 14q32.2, and 1 region with homozygous loss at 9p21.3. Gains of 7p and 7q and loss of 9p21.3 showed a significant association with poor prognosis. PTCL-U cases with genomic imbalance showed distinct histopathologic and prognostic features compared with such cases without alteration and a marked genetic, histopathologic, and prognostic resemblance to lymphoma-type ATLL., Conclusions: The array CGH enabled us to identify the frequently altered genomic regions with strong prognostic power among PTCL-U cases. A correlative analysis using the array CGH data disclosed a subgroup in PTCL-U with genomic alterations and with histopathologic and clinical relevance. In addition to histopathologic similarity, the strong genetic and prognostic resemblance between PTCL-U cases with genomic imbalance detected by array CGH and lymphoma-type ATLL seems to support the notion that the former may constitute a distinct PTCL-U subgroup.

Published
2009
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20. [Epstein-Barr virus (EBV)-associated lymphomas and lymphoproliferative disorders].

Author

Shimoyama Y, Nakamura S, Asano N, Oshiro A, and Oyama T

Subjects
B-Lymphocytes pathology, Hodgkin Disease immunology, Humans, Killer Cells, Natural pathology, Lymphoma, B-Cell immunology, Lymphoma, T-Cell immunology, Lymphoproliferative Disorders immunology, T-Lymphocytes pathology, Herpesvirus 4, Human, Hodgkin Disease virology, Lymphoma, B-Cell virology, Lymphoma, T-Cell virology, Lymphoproliferative Disorders virology
Published
2006

21. [A case of primary malignant lymphoma of the duodenum successfully treated with dose escalating chemotherapy].

Author

Oshiro A, Nagasaki A, Nakachi A, Uchima N, Hasegawa H, Nakazato T, Nakamoto M, Kinjo N, Kinjo F, Taira N, Masuda M, and Takasu N

Subjects
Aged, Doxorubicin analogs & derivatives, Female, Humans, Treatment Outcome, Antineoplastic Combined Chemotherapy Protocols therapeutic use, Cyclophosphamide therapeutic use, Doxorubicin therapeutic use, Duodenal Neoplasms drug therapy, Lymphoma, B-Cell drug therapy, Lymphoma, Large B-Cell, Diffuse drug therapy, Prednisolone therapeutic use, Vincristine therapeutic use
Abstract

A 65-year-old woman with diabetes mellitus was hospitalized for heart failure and anemia in August 2001, and recovered with conservative treatment. An endoscopic examination revealed an ulcerative mass located in the duodenal bulb to the 2nd portion. Abdominal CT scan demonstrated tumor involvement in the pancreas head. The diagnosis of a diffuse large B-cell lymphoma, clinical stage IIE, was made by endoscopic biopsy. Although surgical resection of the localized intestinal tumor would have been a common choice for initial treatment, polychemotherapy was selected; the patient had diabetes mellitus and preferred polychemotherapy to surgical operation. Because of bulky intestinal mass, transmural disease and sensitive histological type, standard-dose chemotherapy was considered to include a high risk of intestinal perforation. We performed dose-escalating chemotherapy: A half dose of THP-COP (pirarubicin, cyclophosphamide, vincristine) was given at the start in October 2001, 60% THP-COP as the next cycle, 80% THP-COP as the 3rd cycle and thereafter. Without serious complications of the intestine, she received a total of 6 cycles of chemotherapy and subsequent involved field radiation. There has been no evidence of recurrence of disease 14 months from the start of chemotherapy. When conditions make surgical treatment difficult, dose-escalating chemotherapy in a treatment cycle may be considered as an alternative.

Published
2003

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