1,195 results on '"Oshimura, Mitsuo"'
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2. Characterization of human anti-EpCAM antibodies for developing an antibody–drug conjugate
3. Full-length human dystrophin on human artificial chromosome compensates for mouse dystrophin deficiency in a Duchenne muscular dystrophy mouse model
4. Co-treatment of CHO cells with Taxol and reversine improves micronucleation and microcell-mediated chromosome transfer efficiency
5. Establishment of an antibody specific for AMIGO2 improves immunohistochemical evaluation of liver metastases and clinical outcomes in patients with colorectal cancer
6. Efficient human-like antibody repertoire and hybridoma production in trans-chromosomic mice carrying megabase-sized human immunoglobulin loci
7. Panel of human cell lines with human/mouse artificial chromosomes
8. Humanized liver TK-NOG mice with functional deletion of hepatic murine cytochrome P450s as a model for studying human drug metabolism
9. Developing a workflow for the isolation of hybridoma cells producing fully human antigen-specific antibodies using a surface IgG detection method
10. Engineering of human induced pluripotent stem cells via human artificial chromosome vectors for cell therapy and disease modeling
11. Evidence for divergence of DNA methylation maintenance and a conserved inhibitory mechanism from DNA demethylation in chickens and mammals
12. Transchromosomic technology for genomically humanized animals
13. Humanized UGT2 and CYP3A transchromosomic rats for improved prediction of human drug metabolism
14. Construction of stable mouse artificial chromosome from native mouse chromosome 10 for generation of transchromosomic mice
15. Treatment of CHO cells with Taxol and reversine improves micronucleation and microcell-mediated chromosome transfer efficiency
16. A luciferase complementation assay system using transferable mouse artificial chromosomes to monitor protein–protein interactions mediated by G protein-coupled receptors
17. Transmission of Genomic Instability from a Single Irradiated Human Chromosome to the Progeny of Unirradiated Cells
18. Complete Absence of Cockayne Syndrome Group B Gene Product Gives Rise to UV-Sensitive Syndrome but Not Cockayne Syndrome
19. Potential Usage of Human Artificial Chromosome for Regenerative Medicine
20. Development of Caco-2 cells co-expressing CYP3A4 and NADPH-cytochrome P450 reductase using a human artificial chromosome for the prediction of intestinal extraction ratio of CYP3A4 substrates
21. Development of Caco-2 cells expressing four CYPs via a mammalian artificial chromosome
22. DNA-PKcs is Critical for Telomere Capping
23. An efficient protein production system via gene amplification on a human artificial chromosome and the chromosome transfer to CHO cells
24. Double Trans-Chromosomic Mice: Maintenance of Two Individual Human Chromosome Fragments Containing Ig Heavy and κ Loci and Expression of Fully Human Antibodies
25. Loss of Imprinting of a Paternally Expressed Transcript, with Antisense Orientation to K v LQT1, Occurs Frequently in Beckwith-Wiedemann Syndrome and Is Independent of Insulin-Like Growth Factor II Imprinting
26. Combinations of chromosome transfer and genome editing for the development of cell/animal models of human disease and humanized animal models
27. Overexpression screen of chromosome 21 genes reveals modulators of Sonic hedgehog signaling relevant to Down syndrome
28. Data from Systematic Analysis of Compounds Specifically Targeting Telomeres and Telomerase for Clinical Implications in Cancer Therapy
29. Supplementary Data from Systematic Analysis of Compounds Specifically Targeting Telomeres and Telomerase for Clinical Implications in Cancer Therapy
30. Supplementary Figures 1-2 from Genetic Instability Caused by Loss of MutS Homologue 3 in Human Colorectal Cancer
31. Supplementary Table 1 from Genetic Instability Caused by Loss of MutS Homologue 3 in Human Colorectal Cancer
32. Data from CTCFL/BORIS Is a Methylation-Independent DNA-Binding Protein That Preferentially Binds to the Paternal H19 Differentially Methylated Region
33. Supplementary Figures 1-6, Methods and Materials from CTCFL/BORIS Is a Methylation-Independent DNA-Binding Protein That Preferentially Binds to the Paternal H19 Differentially Methylated Region
34. Dynamics of epigenetic regulation at the single-cell level
35. Production of a Human Cell Line with a Plant Chromosome
36. Hypermetabolism in mice carrying a near complete human chromosome 21
37. Highly sensitive luciferase reporter assay using a potent destabilization sequence of calpain 3
38. Analysis of in vitro and in vivo metabolism of zidovudine and gemfibrozil in trans‐chromosomic mouse line expressing human UGT2 enzymes
39. Growth Control of Mammalian Cells via a Human Artificial Chromosome Harboring a Chimeric Receptor
40. Reversible immortalisation enables genetic correction of human muscle progenitors and engineering of next‐generation human artificial chromosomes for Duchenne muscular dystrophy
41. Evaluation of 4β-Hydroxycholesterol and 25-Hydroxycholesterol as Endogenous Biomarkers of CYP3A4: Study with CYP3A-Humanized Mice
42. Development of a High-Sensitivity Quantitation Method for Arginine Vasopressin by High-Performance Liquid Chromatography Tandem Mass Spectrometry, and Comparison with Quantitative Values by Radioimmunoassay
43. Overexpression screen of chromosome 21 genes reveals modulators of Sonic hedgehog signaling relevant to Down syndrome
44. An improved TK-NOG mouse as a novel platform for humanized liver that overcomes limitations in both male and female animals
45. Multiple expression cassette exchange via TP901‐1, R4, and Bxb1 integrase systems on a mouse artificial chromosome
46. Mouse embryonic stem cells with a multi-integrase mouse artificial chromosome for transchromosomic mouse generation
47. Bioluminescence imaging of bone formation using hairless osteocalcin-luciferase transgenic mice
48. A pathway from chromosome transfer to engineering resulting in human and mouse artificial chromosomes for a variety of applications to bio-medical challenges
49. A transchromosomic rat model with human chromosome 21 shows robust Down syndrome features
50. An improved TK-NOG mouse as a novel platform for humanized liver that overcomes limitations in both male and female animals
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