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7. Neutral selection and clonal expansion during the development of colon cancer metastasis.

Author

Lei, Xuelian, Yamamoto, Daisuke, Kitamura, Hirotaka, Kita, Kenji, Inaki, Noriyuki, Murakami, Kazuhiro, Nakayama, Mizuho, Oshima, Hiroko, and Oshima, Masanobu

Subjects
LIVER metastasis, LIVER cancer, COLON cancer, CANCER invasiveness, METASTASIS
Abstract

Intratumour heterogeneity has been shown to play a role in the malignant progression of cancer. The clonal evolution in primary cancer has been well studied, however, that in metastatic tumorigenesis is not fully understood. In this study, we established human colon cancer-derived organoids and investigated clonal dynamics during liver metastasis development by tracking barcode-labelled subclones. Long-term subclone co-cultures showed clonal drift, with a single subclone becoming dominant in the cell population. Interestingly, the selected subclones were not always the same, suggesting that clonal selection was not based on cell intrinsic properties. Furthermore, liver tumours developed by co-transplantation of organoid subclones into the immunodeficient mouse spleen showed a progressive drastic reduction in clonal diversity, and only one or two subclones predominated in the majority of large metastatic tumours. Importantly, selections were not limited to particular subclones but appeared to be random. A trend towards a reduction in clonal diversity was also found in liver metastases of multiple colour-labelled organoids of mouse intestinal tumours. Based on these results, we propose a novel mechanism of metastasis development, i.e. a subclone population of the disseminated tumour cells in the liver is selected by neutral selection during colonization and constitutes large metastatic tumours. [ABSTRACT FROM AUTHOR]

Published
2024
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10. Identification of uromodulin deposition in the stroma of perinephric fibromyxoid nephrogenic adenoma by mass spectrometry

Author

Yoshimura, Kaori, primary, Ito, Yukinobu, additional, Suzuki, Mina, additional, Horie, Masafumi, additional, Nishiuchi, Takumi, additional, Shintani‐Domoto, Yukako, additional, Shigehara, Kazuyoshi, additional, Oshima, Hiroko, additional, Oshima, Masanobu, additional, Goto, Akiteru, additional, Nojima, Takayuki, additional, Tsuzuki, Toyonori, additional, Mizokami, Atsushi, additional, Ikeda, Hiroko, additional, and Maeda, Daichi, additional

Published
2024
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19. Contributors

Author

Balasubramanian, Adithya, primary, Bijlsma, Maarten F., additional, Bougen-Zhukov, Nicola, additional, Boussioutas, Alex, additional, Busuttil, Rita A., additional, Carneiro, Fátima, additional, Chuang, Linda Shyue Huey, additional, Davis, Jeremy L., additional, Dawson, Ruby, additional, Dings, Mark P.G., additional, Douchi, Daisuke, additional, Echizen, Kanae, additional, Ferrero, Richard L., additional, Frentzas, Sophia, additional, Guilford, Parry, additional, Gullo, Irene, additional, Han, Tae-Su, additional, Hatakeyama, Masanori, additional, Ito, Yoshiaki, additional, Jenkins, Brendan J., additional, John, Alexius, additional, Jones, David W., additional, Ju, Xiaoli, additional, Kaneda, Atsushi, additional, Koulis, Athanasios, additional, Li, Wenzhe, additional, Lum, Caroline, additional, Matsuo, Junichi, additional, Noto, Jennifer M., additional, Okabe, Atsushi, additional, Oliveira, Carla, additional, Oshima, Hiroko, additional, Oshima, Masanobu, additional, Segelov, Eva, additional, van der Post, Rachel S., additional, van Dieren, Jolanda M., additional, Vermeulen, Louis, additional, and Zavros, Yana, additional

Published
2021
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23. Artists' groups in Japan and the UK and their impact on the creative individual

Author

Oshima, Hiroko and Dye, David

Subjects
708, W100 Fine Art, W200 Design studies
Abstract

The aim of this thesis is to give an alternative insight to the existing concept of individuality in visual art through an examination of the meaning of being individual for visual art practitioners, particularly for those who operate in an artists’ group setting. This research project is a critique of the seemingly unchallenged emphasis on the individuality and its strong association with creativity in the current British art schools. Cultivating individuality is one of the most important aims in both British and Japanese institutions where I have trained as an artist. Nevertheless, my group-oriented cultural background and my membership of an artists’ group studying in an individually-oriented environment raise questions challenging the meaning of being an individual itself. This thesis has no methodology set up at the beginning, which would usually be the case in a conventional academic thesis. Instead, the thesis develops thought experiments to examine what ‘individual’ means in order to arrive at methodology towards the end. Moreover, this piece of practiceled research is not about the contents of my practice but about the group feeling underlying my practice as an individual fine art practitioner. The investigation into the relational idea of the self of Zen, followed by Charles Sanders Peirce’s semiotics of the Universe of Three Categories, provide the research with a useful visual thinking tool: the triadic diagram. The investigation into the meaning of the individual develops further through an exploration of the concept of ‘groupness’. Definitions of the term are carefully unfolded until the terminology allows us to contemplate different senses of the individual: singularity- and groupness- oriented individual. As a result of the thought experiments examining different ideas of one’s individuality, there emerge several action research practice-led methodologies for the fine art practitioner working in a group situation. One methodology brings groupness into my individual practice, and another introduces groupness situations to other practitioners. The contribution of this thesis is to provide a basis for fine art practitioners like myself to revalue their individuality in harmony with their group membership.

Published
2010

31. Supplementary Table S1 from Myeloid Differentiation Factor 88 Signaling in Bone Marrow–Derived Cells Promotes Gastric Tumorigenesis by Generation of Inflammatory Microenvironment

Author

Maeda, Yusuke, primary, Echizen, Kanae, primary, Oshima, Hiroko, primary, Yu, Liang, primary, Sakulsak, Natthiya, primary, Hirose, Osamu, primary, Yamada, Yoichi, primary, Taniguchi, Tadatsugu, primary, Jenkins, Brendan J., primary, Saya, Hideyuki, primary, and Oshima, Masanobu, primary

Published
2023
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32. Data from Ink4a/Arf-Dependent Loss of Parietal Cells Induced by Oxidative Stress Promotes CD44-Dependent Gastric Tumorigenesis

Author

Seishima, Ryo, primary, Wada, Takeyuki, primary, Tsuchihashi, Kenji, primary, Okazaki, Shogo, primary, Yoshikawa, Momoko, primary, Oshima, Hiroko, primary, Oshima, Masanobu, primary, Sato, Toshiro, primary, Hasegawa, Hirotoshi, primary, Kitagawa, Yuko, primary, Goldenring, James R., primary, Saya, Hideyuki, primary, and Nagano, Osamu, primary

Published
2023
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33. Supplementary Methods and Figure legend from Ink4a/Arf-Dependent Loss of Parietal Cells Induced by Oxidative Stress Promotes CD44-Dependent Gastric Tumorigenesis

Author

Seishima, Ryo, primary, Wada, Takeyuki, primary, Tsuchihashi, Kenji, primary, Okazaki, Shogo, primary, Yoshikawa, Momoko, primary, Oshima, Hiroko, primary, Oshima, Masanobu, primary, Sato, Toshiro, primary, Hasegawa, Hirotoshi, primary, Kitagawa, Yuko, primary, Goldenring, James R., primary, Saya, Hideyuki, primary, and Nagano, Osamu, primary

Published
2023
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34. Data from Stemness Is Enhanced in Gastric Cancer by a SET/PP2A/E2F1 Axis

Author

Enjoji, Shuhei, primary, Yabe, Ryotaro, primary, Tsuji, Shunya, primary, Yoshimura, Kazuhiro, primary, Kawasaki, Hideyoshi, primary, Sakurai, Masashi, primary, Sakai, Yusuke, primary, Takenouchi, Hiroko, primary, Yoshino, Shigefumi, primary, Hazama, Shoichi, primary, Nagano, Hiroaki, primary, Oshima, Hiroko, primary, Oshima, Masanobu, primary, Vitek, Michael P., primary, Matsuura, Tetsuya, primary, Hippo, Yoshitaka, primary, Usui, Tatsuya, primary, Ohama, Takashi, primary, and Sato, Koichi, primary

Published
2023
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35. Supplementary Information from Myeloid Differentiation Factor 88 Signaling in Bone Marrow–Derived Cells Promotes Gastric Tumorigenesis by Generation of Inflammatory Microenvironment

Author

Maeda, Yusuke, primary, Echizen, Kanae, primary, Oshima, Hiroko, primary, Yu, Liang, primary, Sakulsak, Natthiya, primary, Hirose, Osamu, primary, Yamada, Yoichi, primary, Taniguchi, Tadatsugu, primary, Jenkins, Brendan J., primary, Saya, Hideyuki, primary, and Oshima, Masanobu, primary

Published
2023
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36. Supplemental Figure S1 from Ink4a/Arf-Dependent Loss of Parietal Cells Induced by Oxidative Stress Promotes CD44-Dependent Gastric Tumorigenesis

Author

Seishima, Ryo, primary, Wada, Takeyuki, primary, Tsuchihashi, Kenji, primary, Okazaki, Shogo, primary, Yoshikawa, Momoko, primary, Oshima, Hiroko, primary, Oshima, Masanobu, primary, Sato, Toshiro, primary, Hasegawa, Hirotoshi, primary, Kitagawa, Yuko, primary, Goldenring, James R., primary, Saya, Hideyuki, primary, and Nagano, Osamu, primary

Published
2023
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37. Supplementary Figure 1 from Myeloid Differentiation Factor 88 Signaling in Bone Marrow–Derived Cells Promotes Gastric Tumorigenesis by Generation of Inflammatory Microenvironment

Author

Maeda, Yusuke, primary, Echizen, Kanae, primary, Oshima, Hiroko, primary, Yu, Liang, primary, Sakulsak, Natthiya, primary, Hirose, Osamu, primary, Yamada, Yoichi, primary, Taniguchi, Tadatsugu, primary, Jenkins, Brendan J., primary, Saya, Hideyuki, primary, and Oshima, Masanobu, primary

Published
2023
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38. Supplementary Figure 5 from Myeloid Differentiation Factor 88 Signaling in Bone Marrow–Derived Cells Promotes Gastric Tumorigenesis by Generation of Inflammatory Microenvironment

Author

Maeda, Yusuke, primary, Echizen, Kanae, primary, Oshima, Hiroko, primary, Yu, Liang, primary, Sakulsak, Natthiya, primary, Hirose, Osamu, primary, Yamada, Yoichi, primary, Taniguchi, Tadatsugu, primary, Jenkins, Brendan J., primary, Saya, Hideyuki, primary, and Oshima, Masanobu, primary

Published
2023
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39. Supplementary information from Stemness Is Enhanced in Gastric Cancer by a SET/PP2A/E2F1 Axis

Author

Enjoji, Shuhei, primary, Yabe, Ryotaro, primary, Tsuji, Shunya, primary, Yoshimura, Kazuhiro, primary, Kawasaki, Hideyoshi, primary, Sakurai, Masashi, primary, Sakai, Yusuke, primary, Takenouchi, Hiroko, primary, Yoshino, Shigefumi, primary, Hazama, Shoichi, primary, Nagano, Hiroaki, primary, Oshima, Hiroko, primary, Oshima, Masanobu, primary, Vitek, Michael P., primary, Matsuura, Tetsuya, primary, Hippo, Yoshitaka, primary, Usui, Tatsuya, primary, Ohama, Takashi, primary, and Sato, Koichi, primary

Published
2023
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40. Figure S5 from Combined Mutation of Apc, Kras, and Tgfbr2 Effectively Drives Metastasis of Intestinal Cancer

Author

Sakai, Eri, primary, Nakayama, Mizuho, primary, Oshima, Hiroko, primary, Kouyama, Yuta, primary, Niida, Atsushi, primary, Fujii, Satoshi, primary, Ochiai, Atsushi, primary, Nakayama, Keiichi I., primary, Mimori, Koshi, primary, Suzuki, Yutaka, primary, Hong, Chang Pyo, primary, Ock, Chan-Young, primary, Kim, Seong-Jin, primary, and Oshima, Masanobu, primary

Published
2023
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41. Table S2 from Combined Mutation of Apc, Kras, and Tgfbr2 Effectively Drives Metastasis of Intestinal Cancer

Author

Sakai, Eri, primary, Nakayama, Mizuho, primary, Oshima, Hiroko, primary, Kouyama, Yuta, primary, Niida, Atsushi, primary, Fujii, Satoshi, primary, Ochiai, Atsushi, primary, Nakayama, Keiichi I., primary, Mimori, Koshi, primary, Suzuki, Yutaka, primary, Hong, Chang Pyo, primary, Ock, Chan-Young, primary, Kim, Seong-Jin, primary, and Oshima, Masanobu, primary

Published
2023
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42. Data from Inflammasome Adaptor ASC Suppresses Apoptosis of Gastric Cancer Cells by an IL18-Mediated Inflammation-Independent Mechanism

Author

Deswaerte, Virginie, primary, Nguyen, Paul, primary, West, Alison, primary, Browning, Alison F., primary, Yu, Liang, primary, Ruwanpura, Saleela M., primary, Balic, Jesse, primary, Livis, Thaleia, primary, Girard, Charlotte, primary, Preaudet, Adele, primary, Oshima, Hiroko, primary, Fung, Ka Yee, primary, Tye, Hazel, primary, Najdovska, Meri, primary, Ernst, Matthias, primary, Oshima, Masanobu, primary, Gabay, Cem, primary, Putoczki, Tracy, primary, and Jenkins, Brendan J., primary

Published
2023
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43. Data from Combined Mutation of Apc, Kras, and Tgfbr2 Effectively Drives Metastasis of Intestinal Cancer

Author

Sakai, Eri, primary, Nakayama, Mizuho, primary, Oshima, Hiroko, primary, Kouyama, Yuta, primary, Niida, Atsushi, primary, Fujii, Satoshi, primary, Ochiai, Atsushi, primary, Nakayama, Keiichi I., primary, Mimori, Koshi, primary, Suzuki, Yutaka, primary, Hong, Chang Pyo, primary, Ock, Chan-Young, primary, Kim, Seong-Jin, primary, and Oshima, Masanobu, primary

Published
2023
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44. Supplementary Data from Inflammasome Adaptor ASC Suppresses Apoptosis of Gastric Cancer Cells by an IL18-Mediated Inflammation-Independent Mechanism

Author

Deswaerte, Virginie, primary, Nguyen, Paul, primary, West, Alison, primary, Browning, Alison F., primary, Yu, Liang, primary, Ruwanpura, Saleela M., primary, Balic, Jesse, primary, Livis, Thaleia, primary, Girard, Charlotte, primary, Preaudet, Adele, primary, Oshima, Hiroko, primary, Fung, Ka Yee, primary, Tye, Hazel, primary, Najdovska, Meri, primary, Ernst, Matthias, primary, Oshima, Masanobu, primary, Gabay, Cem, primary, Putoczki, Tracy, primary, and Jenkins, Brendan J., primary

Published
2023
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47. Supplementary Figure S3 from Suppressing TGFβ Signaling in Regenerating Epithelia in an Inflammatory Microenvironment Is Sufficient to Cause Invasive Intestinal Cancer

Author

Oshima, Hiroko, primary, Nakayama, Mizuho, primary, Han, Tae-Su, primary, Naoi, Kuniko, primary, Ju, Xiaoli, primary, Maeda, Yusuke, primary, Robine, Sylvie, primary, Tsuchiya, Kiichiro, primary, Sato, Toshiro, primary, Sato, Hiroshi, primary, Taketo, Makoto Mark, primary, and Oshima, Masanobu, primary

Published
2023
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49. Data from Suppressing TGFβ Signaling in Regenerating Epithelia in an Inflammatory Microenvironment Is Sufficient to Cause Invasive Intestinal Cancer

Author

Oshima, Hiroko, primary, Nakayama, Mizuho, primary, Han, Tae-Su, primary, Naoi, Kuniko, primary, Ju, Xiaoli, primary, Maeda, Yusuke, primary, Robine, Sylvie, primary, Tsuchiya, Kiichiro, primary, Sato, Toshiro, primary, Sato, Hiroshi, primary, Taketo, Makoto Mark, primary, and Oshima, Masanobu, primary

Published
2023
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50. Supplementary Figure Legends from Suppressing TGFβ Signaling in Regenerating Epithelia in an Inflammatory Microenvironment Is Sufficient to Cause Invasive Intestinal Cancer

Author

Oshima, Hiroko, primary, Nakayama, Mizuho, primary, Han, Tae-Su, primary, Naoi, Kuniko, primary, Ju, Xiaoli, primary, Maeda, Yusuke, primary, Robine, Sylvie, primary, Tsuchiya, Kiichiro, primary, Sato, Toshiro, primary, Sato, Hiroshi, primary, Taketo, Makoto Mark, primary, and Oshima, Masanobu, primary

Published
2023
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