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2. News and Notes

Author

Osgood, L. A. and Logan, C. T.

Published
1928

3. Outcomes of obstructed abdominal wall hernia: results from the UK national small bowel obstruction audit

Author

Lee, MJ, Drake, TM, Sayers, AE, Walsh, CJ, Davies, MM, Fearnhead, NS, Abercrombie, J, Acheson, A, Alderson, D, Anderson, I, Bach, S, Davies, M, Hamady, Z, Hind, D, Hollyman, M, Hare, S, Lee, E, Northover, J, Lewis, C, Marriott, P, Maynard, N, Murray, D, Tierney, G, Verjee, A, Wild, J, Abbott, S, Abdulaal, Y, Afshar, S, Ah‐Chuen, J, Ahmed, T, Akhtar, M, Akram, F, Aldred, E, Ali, A, Aly, M, Amajuoyi, A, Amin, V, Anderson, D, Anderson, O, Andreou, A, Ansari, A, Appleton, S, Ardley, R, Arshad, F, Ashour, O, Asour, A, Athem, A, Athersmith, M, Ayoub, F, Azeem, H, Azhar, B, Badenoch, T, Baillie, C, Bandyopadhyay, D, Barker, J, Barker, S, Barkham, B, Baron, R, Barrie, J, Barry‐Yarrow, E, Bashir, G, Battersby, N, Bazoua, G, Behar, N, Bellam, S, Berger, C, Bhandari, S, Bhasin, S, Biggs, S, Bisset, C, Blake, L, Blencowe, N, Boam, T, Boddy, A, Boereboom, C, Bogdan, M, Bogle, R, Bohra, P, Boland, M, Bolkan, H, Borg, C, Boulton, R, Bouras, G, Boyer, M, Boyle, J, Branagan, G, Brewer, H, Briggs, C, Broadhurst, J, Brown, E, Brown, J, Brown, L, Brown, O, Burns, K, Butcher, K, Butler, M, Byrne, B, Campbell, L, Capper, C, Cartmell, M, Cash, T, Chan, S, Chandratreya, N, Chapman, J, Chapman, S, Charalabopoulos, A, Cheek, C, Chok, S, Choong, W, Chow, M, Chowdhury, J, Coe, P, Conaghan, P, Conn, G, Cook, N, Cook, T, Cooper, S, Cornish, J, Cotton, D, Cox, C, Coyne, P, Crook, R, Crozier, J, Cuffolo, G, Cunha, P, Curtis, N, Cutting, J, Da Costa, K, Silva, L, Das, B, Davenport, M, Davies, J, Davies, T, Day, A, Dayal, S, Dean, S, Demetriou, G, Dengu, F, Dennis, R, Dent, H, Dent, P, Deputy, M, Devoto, L, Di Benedetto, G, Dindyal, S, Donnelly, E, Doody, P, Douka, E, Downham, C, Dowson, H, Edent, H, Edgerton, K, Ekpete, N, El Farran, M, Elamin, O, Eljaafari, M, Elsaid, N, El‐Sharif, M, Evans, J, Evans, M, Ewe, R, Ewing, A, Exarchou, K, Fallaize, R, Faoury, M, Farag, S, Farinella, E, Faulkner, G, Ferguson, H, Fisher, O, Fletcher, J, Forouzanfar, A, Foster, A, Fox, R, Francis, N, Fretwell, V, Fung, D, Gammeri, E, Garnham, J, Geraghty, A, Gilbert, A, Gill, C, Gill, M, Gillespie, M, Giordano, P, Glasbey, J, Goh, M, Golder, A, Green, N, Gregoir, T, Grey, T, Groundwater, E, Grove, T, Growcott, S, Gunasekaran, S, Habib, H, Haddow, J, Halahakoon, V, Halkias, C, Hall, C, Hampson, A, Hancock, L, Hanna, T, Hannay, J, Harikrishnan, A, Harries, R, Harris, G, Hartley, J, Harvey, K, Hawkin, P, Hawkins, J, Healy, R, Heard, R, Heartshorne, R, Heller, S, Hendra, L, Herrod, P, Heywood, N, Hicks, G, Hobson, B, Holtham, S, Hope, C, Hopley, P, Hossain, T, Hossaini, S, Howse, F, Hubbard, T, Humphreys, A, Ikram, H, Ioannis, M, Iqbal, M, Iqbal, N, Jain, R, Jatania, J, Jenkinson, P, Jokhan, S, Jones, A, Jones, C, Jones, L, Joshi, H, Joshi, K, Joy, M, Jull, P, Kakaniaris, G, Kallam, R, Kane, E, Kang, P, Kanitkar, R, Kauser, S, Kazmi, F, Kedrzycki, M, Kelly, S, Kendall, J, Khan, M, Khan, T, King, G, Kisiel, A, Kitsis, C, Kolawole, I, Korambayil, S, Kosasih, S, Kosti, A, Kotb, A, Kouris, S, Kshatriya, K, Kumar, S, Lafaurie, G, Lal, R, Lau, A, Lazim, T, Lazzaro, A, Lee, K, Lefroy, R, Leinhardt, D, Lennon, H, Leong, K, Levy, B, Lim, E, Lim, J, Lindley, S, Liu, D, Lloyd, P, Locker, D, Lockwood, S, Lowe, C, Lund, J, Lunevicius, R, Lunt, A, Lutfi, S, Luther, A, Luwemba, S, Mahankali‐Rao, P, Mahroof, S, Mai, D, Majid, S, Malik, A, Malik, K, Mann, K, Mansour, S, Manu, N, Mapara, R, Martin, C, Martin, J, Martin, R, Mason, C, Massey, L, Mathias, J, Mathur, P, Maude, K, McArthur, D, McCain, S, McCluney, S, McFall, M, McIlroy, B, McKay, S, McKinley, N, McNair, A, McWhirter, D, Mekhail, P, Mellor, K, Merchant, J, Merker, L, Messenger, D, Miles, A, Mir, S, Mishra, A, Mistry, P, Miu, V, Moat, M, Mockford, K, Mohamed, E, Mohamed, I, Mondragon‐Pritchard, M, Moore, N, Moretti, L, Morris, H, Morrison, T, Morrison‐Jones, V, Moss, J, Moug, S, Mountford, D, Moynihan, R, Muhammad, K, Muldoon‐Smith, D, Mulholland, J, Mullan, M, Murgitroyd, E, Murugaiyan, K, Myers, A, Mykoniatis, I, Nana, G, Nash, T, Nassar, A, Newton, R, Ng, C, Ng, P, Nguyen, K, Nicholas, F, Noor, M, Nowers, J, Nugent, C, Nunn, A, Nunn, R, Obeid, N, O'Callaghan, J, O'Hara, R, Oke, O, Olivier, J, O'Neill, A, O'Neill, S, Osei‐Bordom, D, Osgood, L, Panagiotopoulos, S, Panchasara, B, Parks, R, Patel, H, Patel, P, Patel, R, Patel, S, Pawelec, K, Payne, C, Pearson, K, Perin, G, Peristerakis, I, Petronio, B, Phelan, L, Phillips, J, Pisaneschi, C, Pitt, J, Plunkett‐Reed, K, Ponchietti, L, Pouzi, A, Pouzi, M, Powell, A, Powell‐Chandler, A, Pranesh, N, Proctor, V, Pywell, S, Qureshi, A, Qureshi, N, Rahman, M, Rai, Z, Ramcharan, S, Rangarajan, K, Rashid, M, Reader, H, Rehman, A, Rehman, S, Rengifo, C, Richards, E, Richardson, N, Robinson, A, Robinson, D, Rossi, B, Rutherford, F, Sadien, I, Saghir, T, Sahnan, K, Salahia, G, Sarveswaran, J, Saunders, M, Scott, B, Scott, K, Seager, A, Seal, S, Sezen, E, Shaban, F, Shah, P, Shahmohammadi, M, Shamsiddinova, A, Shankar, S, Sharpe, A, Shatkar, V, Sheel, A, Shields, T, Shinkwin, M, Shurmer, J, Siddika, A, Siddiqui, S, Simson, R, Sinclair, P, Singh, B, Singh, S, Sivaraj, J, Skaife, P, Skelly, B, Skinner, A, Slim, N, Smart, C, Smart, N, Smith, F, Smith, I, Smith, R, Spence, G, Sreedhar, A, Steinke, J, Stevenson, L, Stewart‐Parker, E, Stott, M, Stubbs, B, Stylianides, N, Subramonia, S, Swinkin, M, Swinscoe, M, Symons, N, Tahir, W, Taj, T, Takacs, K, Tam, J, Tan, K, Tani, S, Tanner, N, Tao, D, Taylor, M, Thava, B, Thippeswamy, K, Thomas, C, Thompson, E, Thompson, R, Thompson‐Reil, C, Thorn, C, Tongo, F, Toth, G, Turnbull, A, Turnbull, J, Valero, C, Boxel, G, Varcada, M, Venn, M, Ventham, N, Venza, M, Vimalachandran, D, Virlos, I, Wade, T, Wafi, A, Waite, K, Walker, M, Walker, N, Walker, T, Walsh, U, Wardle, S, Warner, R, Watfah, J, Watson, N, Watt, J, Watts, J, Wayman, J, Weegenaar, C, West, H, West, M, Whitehurst, L, Whyler, M, Wiggans, M, Wijeyekoon, S, Williams, G, Williams, R, Williamson, A, Williamson, J, Wilson, J, Winter, A, Wolpert, L, Wong, J, Yeap, E, Yeong, T, Zaman, S, Zappa, B, and Zosimas, D

Subjects
Adult, Male, medicine.medical_specialty, National Audit of Small Bowel Obstruction Steering Group and National Audit of Small Bowel Obstruction Collaborators, Incisional hernia, lcsh:Surgery, 030230 surgery, Abdominal wall, 03 medical and health sciences, 0302 clinical medicine, Postoperative Complications, NASBO Collaborators, medicine, Humans, Hernia, Hospital Mortality, General, Emergency Treatment, Aged, Proportional Hazards Models, Aged, 80 and over, Groin, business.industry, Mortality rate, Hazard ratio, West Midlands Research Collaborative, General Medicine, Odds ratio, Original Articles, lcsh:RD1-811, Middle Aged, medicine.disease, Quality Improvement, United Kingdom, Surgery, Hernia, Abdominal, Bowel obstruction, medicine.anatomical_structure, Logistic Models, 030220 oncology & carcinogenesis, Original Article, Female, business, NASBO Steering Group, Intestinal Obstruction
Abstract

Background Abdominal wall hernia is a common surgical condition. Patients may present in an emergency with bowel obstruction, incarceration or strangulation. Small bowel obstruction (SBO) is a serious surgical condition associated with significant morbidity. The aim of this study was to describe current management and outcomes of patients with obstructed hernia in the UK as identified in the National Audit of Small Bowel Obstruction (NASBO). Methods NASBO collated data on adults treated for SBO at 131 UK hospitals between January and March 2017. Those with obstruction due to abdominal wall hernia were included in this study. Demographics, co‐morbidity, imaging, operative treatment, and in‐hospital outcomes were recorded. Modelling for factors associated with mortality and complications was undertaken using Cox proportional hazards and multivariable regression modelling. Results NASBO included 2341 patients, of whom 415 (17·7 per cent) had SBO due to hernia. Surgery was performed in 312 (75·2 per cent) of the 415 patients; small bowel resection was required in 198 (63·5 per cent) of these operations. Non‐operative management was reported in 35 (54 per cent) of 65 patients with a parastomal hernia and in 34 (32·1 per cent) of 106 patients with an incisional hernia. The in‐hospital mortality rate was 9·4 per cent (39 of 415), and was highest in patients with a groin hernia (11·1 per cent, 17 of 153). Complications were common, including lower respiratory tract infection in 16·3 per cent of patients with a groin hernia. Increased age was associated with an increased risk of death (hazard ratio 1·05, 95 per cent c.i. 1·01 to 1·10; P = 0·009) and complications (odds ratio 1·05, 95 per cent c.i. 1·02 to 1·09; P = 0·001). Conclusion NASBO has highlighted poor outcomes for patients with SBO due to hernia, highlighting the need for quality improvement initiatives in this group., This study shows that small bowel obstruction due to abdominal wall hernia is common, typically involves a co‐morbid group of patients and has poor outcomes, including high mortality rates. High mortality from this problem

Published
2020

5. National prospective cohort study of the burden of acute small bowel obstruction

Author

Lee, M. J., Sayers, A. E., Drake, T. M., Marriott, P. J., Anderson, I. D., Bach, S. P., Bradburn, M., Hind, D., Verjee, A., Fearnhead, N. S., Abercrombie, John, Acheson, Austin, Alderson, Derek, Anderson, Iain, Davies, Michael, Hamady, Zaed, Hollyman, Marianne, Hare, Sarah, Lee, Ellen, Northover, John, Lewis, Christopher, McFall, Malcolm, Murugananthan, Aravinth, Murray, David, Singh, Pritam, Tierney, Gillian, Walsh, Ciaran, Wild, Jonathan, Wilson, Timothy, Abbott, S, Abdulaal, Y, Afshar, S, Ah‐Chuen, J, Ahmed, T, Akhtar, M, Akram, F, Aldred, E, Ali, A, Aly, M, Amajuoyi, A, Amin, V, Anderson, D, Anderson, O, Andreou, A, Ansari, A, Appleton, S, Ardley, R, Arshad, F, Ashour, O, Asour, A, Athem, A, Athersmith, M, Ayoub, F, Azeem, H, Azhar, B, Badenoch, T, Baillie, C, Bandyopadhyay, D, Barker, J, Barker, S, Barkham, B, Baron, R, Barrie, J, Barry‐Yarrow, E, Bashir, G, Battersby, N, Bazoua, G, Behar, N, Bellam, S, Berger, C, Bhandari, S, Bhasin, S, Biggs, S, Bisset, C, Blake, L, Blencowe, N, Boam, T, Boddy, A, Boereboom, C, Bogdan, M, Bogle, R, Bohra, P, Boland, M, Bolkan, H, Borg, C, Boulton, R, Bouras, G, Boyer, M, Boyle, J, Branagan, G, Brewer, H, Briggs, C, Broadhurst, J, Brown, E, Brown, J, Brown, L, Brown, O, Burns, K, Butcher, K, Butler, M, Byrne, B, Campbell, L, Capper, C, Cartmell, M, Cash, T, Chan, S, Chandratreya, N, Chapman, J, Chapman, S, Charalabopoulos, A, Cheek, C, Chok, S, Choong, W, Chow, M, Chowdhury, J, Coe, P, Conaghan, P, Conn, G, Cook, N, Cook, T, Cooper, S, Cornish, J, Cotton, D, Cox, C, Coyne, P, Crook, R, Crozier, J, Cuffolo, G, Cunha, P, Curtis, N, Cutting, J, Da Costa, K, Silva, L, Das, B, Davenport, M, Davies, J, Davies, T, Day, A, Dayal, S, Dean, S, Demetriou, G, Dengu, F, Dennis, R, Dent, H, Dent, P, Deputy, M, Devoto, L, Di Benedetto, G, Dindyal, S, Donnelly, E, Doody, P, Douka, E, Downham, C, Dowson, H, Edent, H, Edgerton, K, Ekpete, N, El Farran, M, Elamin, O, Eljaafari, M, Elsaid, N, El‐Sharif, M, Evans, J, Evans, M, Ewe, R, Ewing, A, Exarchou, K, Fallaize, R, Faoury, M, Farag, S, Farinella, E, Faulkner, G, Ferguson, H, Fisher, O, Fletcher, J, Forouzanfar, A, Foster, A, Fox, R, Francis, N, Fretwell, V, Fung, D, Gammeri, E, Garnham, J, Geraghty, A, Gilbert, A, Gill, C, Gill, M, Gillespie, M, Giordano, P, Glasbey, J, Goh, M, Golder, A, Green, N, Gregoir, T, Grey, T, Groundwater, E, Grove, T, Growcott, S, Gunasekaran, S, Habib, H, Haddow, J, Halahakoon, V, Halkias, C, Hall, C, Hampson, A, Hancock, L, Hanna, T, Hannay, J, Harikrishnan, A, Harries, R, Harris, G, Hartley, J, Harvey, K, Hawkin, P, Hawkins, J, Healy, R, Heard, R, Heartshorne, R, Heller, S, Hendra, L, Herrod, P, Heywood, N, Hicks, G, Hobson, B, Holtham, S, Hope, C, Hopley, P, Hossain, T, Hossaini, S, Howse, F, Hubbard, T, Humphreys, A, Ikram, H, Ioannis, M, Iqbal, M, Iqbal, N, Jain, R, Jatania, J, Jenkinson, P, Jokhan, S, Jones, A, Jones, C, Jones, L, Joshi, H, Joshi, K, Joy, M, Jull, P, Kakaniaris, G, Kallam, R, Kane, E, Kang, P, Kanitkar, R, Kauser, S, Kazmi, F, Kedrzycki, M, Kelly, S, Kendall, J, Khan, M, Khan, T, King, G, Kisiel, A, Kitsis, C, Kolawole, I, Korambayil, S, Kosasih, S, Kosti, A, Kotb, A, Kouris, S, Kshatriya, K, Kumar, S, Lafaurie, G, Lal, R, Lau, A, Lazim, T, Lazzaro, A, Lee, K, Lefroy, R, Leinhardt, D, Lennon, H, Leong, K, Levy, B, Lim, E, Lim, J, Lindley, S, Liu, D, Lloyd, P, Locker, D, Lockwood, S, Lowe, C, Lund, J, Lunevicius, R, Lunt, A, Lutfi, S, Luther, A, Luwemba, S, Mahankali‐Rao, P, Mahroof, S, Mai, D, Majid, S, Malik, A, Malik, K, Mann, K, Mansour, S, Manu, N, Mapara, R, Martin, C, Martin, J, Martin, R, Mason, C, Massey, L, Mathias, J, Mathur, P, Maude, K, McArthur, D, McCain, S, McCluney, S, McIlroy, B, McKay, S, McKinley, N, McNair, A, McWhirter, D, Mekhail, P, Mellor, K, Merchant, J, Merker, L, Messenger, D, Miles, A, Mir, S, Mishra, A, Mistry, P, Miu, V, Moat, M, Mockford, K, Mohamed, E, Mohamed, I, Mondragon‐Pritchard, M, Moore, N, Moretti, L, Morris, H, Morrison, T, Morrison‐Jones, V, Moss, J, Moug, S, Mountford, D, Moynihan, R, Muhammad, K, Muldoon‐Smith, D, Mulholland, J, Mullan, M, Murgitroyd, E, Murugaiyan, K, Myers, A, Mykoniatis, I, Nana, G, Nash, T, Nassar, A, Newton, R, Ng, C, Ng, P, Nguyen, K, Nicholas, F, Noor, M, Nowers, J, Nugent, C, Nunn, A, Nunn, R, Obeid, N, O'Callaghan, J, O'Hara, R, Oke, O, Olivier, J, O'Neill, A, O'Neill, S, Osei‐Bordom, D, Osgood, L, Panagiotopoulos, S, Panchasara, B, Parks, R, Patel, H, Patel, P, Patel, R, Patel, S, Pawelec, K, Payne, C, Pearson, K, Perin, G, Peristerakis, I, Petronio, B, Phelan, L, Phillips, J, Pisaneschi, C, Pitt, J, Plunkett‐Reed, K, Ponchietti, L, Pouzi, A, Pouzi, M, Powell, A, Powell‐Chandler, A, Pranesh, N, Proctor, V, Pywell, S, Qureshi, A, Qureshi, N, Rahman, M, Rai, Z, Ramcharan, S, Rangarajan, K, Rashid, M, Reader, H, Rehman, A, Rehman, S, Rengifo, C, Richards, E, Richardson, N, Robinson, A, Robinson, D, Rossi, B, Rutherford, F, Sadien, I, Saghir, T, Sahnan, K, Salahia, G, Sarveswaran, J, Saunders, M, Scott, B, Scott, K, Seager, A, Seal, S, Sezen, E, Shaban, F, Shah, P, Shahmohammadi, M, Shamsiddinova, A, Shankar, S, Sharpe, A, Shatkar, V, Sheel, A, Shields, T, Shinkwin, M, Shurmer, J, Siddika, A, Siddiqui, S, Simson, R, Sinclair, P, Singh, B, Singh, S, Sivaraj, J, Skaife, P, Skelly, B, Skinner, A, Slim, N, Smart, C, Smart, N, Smith, F, Smith, I, Smith, R, Spence, G, Sreedhar, A, Steinke, J, Stevenson, L, Stewart‐Parker, E, Stott, M, Stubbs, B, Stylianides, N, Subramonia, S, Swinkin, M, Swinscoe, M, Symons, N, Tahir, W, Taj, T, Takacs, K, Tam, J, Tan, K, Tani, S, Tanner, N, Tao, D, Taylor, M, Thava, B, Thippeswamy, K, Thomas, C, Thompson, E, Thompson, R, Thompson‐Reil, C, Thorn, C, Tongo, F, Toth, G, Turnbull, A, Turnbull, J, Valero, C, Boxel, G, Varcada, M, Venn, M, Ventham, N, Venza, M, Vimalachandran, D, Virlos, I, Wade, T, Wafi, A, Waite, K, Walker, M, Walker, N, Walker, T, Walsh, U, Wardle, S, Warner, R, Watfah, J, Watson, N, Watt, J, Watts, J, Wayman, J, Weegenaar, C, West, H, West, M, Whitehurst, L, Whyler, M, Wiggans, M, Wijeyekoon, S, Williams, G, Williams, R, Williamson, A, Williamson, J, Wilson, J, Winter, A, Wolpert, L, Wong, J, Yeap, E, Yeong, T, Zaman, S, Zappa, B, Zosimas, D, Moug S Mondragon‐Pritchard, M, Rehan, S, and van Boxel, G

Abstract

Background: \ud Small bowel obstruction is a common surgical emergency, and is associated with high levels of morbidity and mortality across the world. The literature provides little information on the conservatively managed group. The aim of this study was to describe the burden of small bowel obstruction in the UK.\ud \ud Methods: \ud This prospective cohort study was conducted in 131 acute hospitals in the UK between January and April 2017, delivered by trainee research collaboratives. Adult patients with a diagnosis of mechanical small bowel obstruction were included. The primary outcome was in‐hospital mortality. Secondary outcomes included complications, unplanned intensive care admission and readmission within 30 days of discharge. Practice measures, including use of radiological investigations, water soluble contrast, operative and nutritional interventions, were collected.\ud \ud Results: \ud Of 2341 patients identified, 693 (29·6 per cent) underwent immediate surgery (within 24 h of admission), 500 (21·4 per cent) had delayed surgery after initial conservative management, and 1148 (49·0 per cent) were managed non‐operatively. The mortality rate was 6·6 per cent (6·4 per cent for non‐operative management, 6·8 per cent for immediate surgery, 6·8 per cent for delayed surgery; P = 0·911). The major complication rate was 14·4 per cent overall, affecting 19·0 per cent in the immediate surgery, 23·6 per cent in the delayed surgery and 7·7 per cent in the non‐operative management groups (P < 0·001). Cox regression found hernia or malignant aetiology and malnutrition to be associated with higher rates of death. Malignant aetiology, operative intervention, acute kidney injury and malnutrition were associated with increased risk of major complication.\ud \ud Conclusion: \ud Small bowel obstruction represents a significant healthcare burden. Patient‐level factors such as timing of surgery, acute kidney injury and nutritional status are factors that might be modified to improve outcomes.

Published
2019

8. Outcomes following small bowel obstruction due to malignancy in the national audit of small bowel obstruction

Author

Drake, Thomas M., primary, Lee, Matthew J., additional, Sayers, Adele E., additional, Abercrombie, John, additional, Acheson, Austin, additional, Alderson, Derek, additional, Anderson, Iain, additional, Bradburn, Mike, additional, Davies, Michael, additional, Hamady, Zaed, additional, Hind, Daniel, additional, Hollyman, Marianne, additional, Hare, Sarah, additional, Lee, Ellen, additional, Northover, John, additional, Lewis, Christopher, additional, Marriott, Paul J., additional, Maynard, Nick, additional, McFall, Malcolm, additional, Muragananthan, Aravinth, additional, Murray, David, additional, Singh, Pritam, additional, Tierney, Gillian, additional, Verjee, Azmina, additional, Walsh, Ciaran, additional, Wild, Jonathan RL., additional, Wilson, Timothy, additional, Abbott, S., additional, Abdulaal, Y., additional, Afshar, S., additional, Akhtar, M., additional, Anderson, D., additional, Appleton, S., additional, Bandyopadhyay, D., additional, Bashir, G., additional, Behar, N., additional, Bhandari, S., additional, Branagan, G., additional, Boulton, R., additional, Borg, C., additional, Bouras, G., additional, Boyle, J., additional, Brewer, H., additional, Brown, L., additional, Briggs, C., additional, Cartmell, M., additional, Chan, S., additional, Chandratreya, N., additional, Conaghan, P., additional, Cornish, J., additional, Cotton, D., additional, Coyne, P., additional, Crozier, J., additional, Cook, T., additional, Cunha, P., additional, Curtis, N., additional, Day, A., additional, Dayal, S., additional, Dennis, R., additional, Dent, P., additional, Dowson, H., additional, Fallaize, R., additional, Farag, S., additional, El Farran, M., additional, Faulkner, G., additional, Giordano, P., additional, Grey, T., additional, Halahakoon, V., additional, Hannay, J., additional, Harikrishnan, A., additional, Holtham, S., additional, Hawkin, P., additional, Hall, C., additional, Hancock, L., additional, Hartley, J., additional, Howse, F., additional, Kallam, R., additional, Kakaniaris, G., additional, Kelly, S., additional, Lockwood, S., additional, Leinhardt, D., additional, Levy, B., additional, Lal, R., additional, Lazim, T., additional, Lund, J., additional, Lunevicius, R., additional, Mathur, P., additional, Maude, K., additional, McArthur, D., additional, McIlroy, B., additional, Miles, A., additional, Moug, S., additional, Mondragon-Pritchard, M., additional, Messenger, D., additional, Mullan, M., additional, Myers, A., additional, Muhammad, K., additional, Mason, C., additional, Sarveswaran, J., additional, Shatkar, V., additional, Singh, B., additional, Skelly, B., additional, Subramonia, S., additional, Swinscoe, M., additional, Thava, B., additional, Thorn, C., additional, Panagiotopoulos, S., additional, Patel, P., additional, Phillips, J., additional, Peristerakis, I., additional, Qureshi, A., additional, Saunders, M., additional, Shah, P., additional, Sheel, A., additional, Siddiqui, S., additional, Skaife, P., additional, Smart, N., additional, Smith, I., additional, Stevenson, L., additional, Stylianides, N., additional, Steinke, J., additional, Stubbs, B., additional, Thompson, R., additional, Varcada, M., additional, Vimalachandran, D., additional, Virlos, I., additional, Watfah, J., additional, Watson, N., additional, Walker, M., additional, Ventham, N., additional, West, H., additional, Wilson, J., additional, Wijeyekoon, S., additional, Ah-Chuen, J., additional, Ahmed, T., additional, Akram, F., additional, Aldred, E., additional, Ali, A., additional, Aly, M., additional, Amajuoyi, A., additional, Amin, V., additional, Andreou, A., additional, Ansari, A., additional, Ardley, R., additional, Arshad, F., additional, Ashour, O., additional, Asour, A., additional, Ayoub, F., additional, Azeem, H., additional, Azhar, B., additional, Baillie, C., additional, Barker, J., additional, Barkham, B., additional, Baron, R., additional, Barrie, J., additional, Barry-Yarrow, E., additional, Battersby, N., additional, Bazoua, G., additional, Berger, C., additional, Bhasin, S., additional, Biggs, S., additional, Bisset, C., additional, Blencowe, N., additional, Boddy, A., additional, Boereboom, C., additional, Bogdan, M., additional, Bogle, R., additional, Bohra, P., additional, Bolkan, H., additional, Boyer, M., additional, Broadhurst, J., additional, Brown, E., additional, Brown, J., additional, Burns, K., additional, Butcher, K., additional, Capper, C., additional, Cash, T., additional, Chapman, J., additional, Chapman, S., additional, Charalabopoulos, A., additional, Cheek, C., additional, Chok, S., additional, Choong, W., additional, Chowdhury, J., additional, Coe, P., additional, Conn, G., additional, Cook, N., additional, Cooper, S., additional, Cox, C., additional, Crook, R., additional, Cuffolo, G., additional, da Silva, L., additional, Das, B., additional, Davenport, M., additional, Davies, J., additional, Davies, T., additional, Dean, S., additional, Demetriou, G., additional, Dengu, F., additional, Dent, H., additional, Di Benedetto, G., additional, Dindyal, S., additional, Donnelly, E., additional, Douka, E., additional, Downham, C., additional, Edent, H., additional, Edgerton, K., additional, El-Sharif, M., additional, Elamin, O., additional, Elsaid, N., additional, Evans, J., additional, Evans, M., additional, Ewe, R., additional, Ewing, A., additional, Ferguson, H., additional, Fisher, O., additional, Fletcher, J., additional, Forouzanfar, A., additional, Foster, A., additional, Fox, R., additional, Francis, N., additional, Fretwell, V., additional, Fung, D., additional, Gammeri, E., additional, Garnham, J., additional, Geraghty, A., additional, Gilbert, A., additional, Gill, M., additional, Gillespie, M., additional, Glasbey, J., additional, Golder, A., additional, Green, N., additional, Groundwater, E., additional, Grove, T., additional, Habib, H., additional, Haddow, J., additional, Halkias, C., additional, Hampson, A., additional, Hanna, T., additional, Harries, R., additional, Harvey, K., additional, Hawkins, J., additional, Healy, R., additional, Heartshorne, R., additional, Heller, S., additional, Hendra, L., additional, Herrod, P., additional, Heywood, N., additional, Hicks, G., additional, Ng, P., additional, Hope, C., additional, Hopley, P., additional, Hossain, T., additional, Hossaini, S., additional, Hubbard, T., additional, Humphreys, A., additional, Ikram, H., additional, Ioannis, M., additional, Iqbal, M., additional, Jatania, J., additional, Jenkinson, P., additional, Jokhan, S., additional, Jones, A., additional, Jones, C., additional, Jones, L., additional, Joshi, H., additional, Joshi, K., additional, Joy, M., additional, Jull, P., additional, Kane, E., additional, Kanitkar, R., additional, Kauser, S., additional, Kazmi, F., additional, Kedrzycki, M., additional, Kendall, J., additional, Khan, T., additional, King, G., additional, Kisiel, A., additional, Kitsis, C., additional, Kolawole, I., additional, Kosasih, S., additional, Kosti, A., additional, Kotb, A., additional, Lau, A., additional, Lafaurie, G., additional, Lazzaro, A., additional, Lefroy, R., additional, Lennon, H., additional, Leong, K., additional, Lim, E., additional, Lim, J., additional, Lindley, S., additional, Liu, D., additional, Lloyd, P., additional, Locker, D., additional, Lowe, C., additional, Lunt, A., additional, Lutfi, S., additional, Luther, A., additional, Luwemba, S., additional, Mahankali-Rao, P., additional, Mai, D., additional, Majid, S., additional, Malik, A., additional, Manu, N., additional, Mapara, R., additional, Martin, C., additional, Martin, J., additional, Massey, L., additional, Mathias, J., additional, McCain, S., additional, McCluney, S., additional, McNair, A., additional, Mekhail, P., additional, Merchant, J., additional, Merker, L., additional, Mir, S., additional, Mistry, P., additional, Miu, V., additional, Moat, M., additional, Mohamed, E., additional, Mohamed, I., additional, Moore, N., additional, Moretti, L., additional, Morris, H., additional, Morrison, T., additional, Moss, J., additional, Mountford, D., additional, Moynihan, R., additional, Muldoon-Smith, D., additional, Mulholland, J., additional, Murgitroyd, E., additional, Murugaiyan, K., additional, Mykoniatis, I., additional, Nana, G., additional, Nash, T., additional, Nassar, A., additional, Newton, R., additional, Nguyen, K., additional, Nicholas, F., additional, Noor, M., additional, Nowers, J., additional, Nugent, C., additional, Nunn, A., additional, O'Callaghan, J., additional, O'Hara, R., additional, O'Neill, A., additional, Olivier, J., additional, Osei-Bordom, D., additional, Osgood, L., additional, Panchasara, B., additional, Parks, R., additional, Patel, H., additional, Pawelec, K., additional, Payne, C., additional, Pearson, K., additional, Perin, G., additional, Petronio, B., additional, Phelan, L., additional, Pisaneschi, C., additional, Pitt, J., additional, Ponchietti, L., additional, Powell, A., additional, Powell-Chandler, A., additional, Pranesh, N., additional, Proctor, V., additional, Qureshi, N., additional, Rahman, M., additional, Rai, Z., additional, Ramcharan, S., additional, Rangarajan, K., additional, Rashid, M., additional, Reader, H., additional, Rehman, A., additional, Rehan, S., additional, Rengifo, C., additional, Richardson, N., additional, Robinson, A., additional, Robinson, D., additional, Rossi, B., additional, Rutherford, F., additional, Sadien, I., additional, Saghir, T., additional, Sahnan, K., additional, Salahia, G., additional, Scott, B., additional, Scott, K., additional, Seager, A., additional, Seal, S., additional, Sezen, E., additional, Shaban, F., additional, Shahmohammadi, M., additional, Shamsiddinova, A., additional, Shankar, S., additional, Sharpe, A., additional, Shields, T., additional, Shinkwin, M., additional, Shurmer, J., additional, Siddika, A., additional, Simson, R., additional, Singh, S., additional, Sivaraj, J., additional, Skinner, A., additional, Smart, C., additional, Smith, F., additional, Smith, R., additional, Sreedhar, A., additional, Stewart-Parker, E., additional, Stott, M., additional, Symons, N., additional, Taj, T., additional, Tam, J., additional, Tan, K., additional, Tani, S., additional, Tao, D., additional, Thippeswamy, K., additional, Thomas, C., additional, Thompson, E., additional, Thompson-Reil, C., additional, Tongo, F., additional, Toth, G., additional, Turnbull, A., additional, Turnbull, J., additional, Wade, T., additional, Wafi, A., additional, Waite, K., additional, Walker, N., additional, Walker, T., additional, Walsh, U., additional, Wardle, S., additional, Warner, R., additional, Watt, J., additional, Watts, J., additional, Wayman, J., additional, Weegenaar, C., additional, West, M., additional, Whyler, M., additional, Whitehurst, L., additional, Wiggans, M., additional, Williams, G., additional, Williams, R., additional, Williamson, A., additional, Williamson, J., additional, Winter, A., additional, Wolpert, L., additional, Wong, J., additional, van Boxel, G., additional, Yeap, E., additional, Zaman, S., additional, Zappa, B., additional, Zosimas, D., additional, Anderson, O., additional, Athem, A., additional, Athersmith, M., additional, Badenoch, T., additional, Barker, S., additional, Bellam, S., additional, Boam, T., additional, Boland, M., additional, Blake, L., additional, Brown, O., additional, Butler, M., additional, Byrne, B., additional, Campbell, L., additional, Chow, M., additional, Da Costa, K., additional, Cutting, J., additional, Deputy, M., additional, Devoto, L., additional, Doody, P., additional, Ekpete, N., additional, Eljaafari, M., additional, Exarchou, K., additional, Faoury, M., additional, Farinella, E., additional, Gill, C., additional, Goh, M., additional, Gregoir, T., additional, Growcott, S., additional, Gunasekaran, S., additional, Harris, G., additional, Heard, R., additional, Hobson, B., additional, Iqbal, N., additional, Jain, R., additional, Kang, P., additional, Khan, M., additional, Korambayil, S., additional, Kouris, S., additional, Kshatriya, K., additional, Kumar, S., additional, Lee, K., additional, Mahroof, S., additional, Malik, K., additional, Mann, K., additional, Mansour, S., additional, Martin, R., additional, McKay, S., additional, McKinley, N., additional, McWhirter, D., additional, Mellor, K., additional, Mishra, A., additional, Mockford, K., additional, Morrison-Jones, V., additional, Ng, C., additional, Nunn, R., additional, O'Neill, S., additional, Oke, O., additional, Obeid, N., additional, Patel, R., additional, Patel, S., additional, Plunkett-Reed, K., additional, Pouzi, M., additional, Pywell, S., additional, Richards, E., additional, Sinclair, P., additional, Slim, N., additional, Spence, G., additional, Swinkin, M., additional, Tahir, W., additional, Takacs, K., additional, Tanner, N., additional, Taylor, M., additional, Valero, C., additional, Venn, M., additional, Venza, M., additional, Yeong, T., additional, and Fearnhead, Nicola S., additional

Published
2019
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10. Basic Science * 208. Stem Cell Factor Expression is Increased in the Skin of Patients with Systemic Sclerosis and Promotes Proliferation and Migration of Fibroblasts in vitro

Author

Karrar, S., primary, Shiwen, X., additional, Nikotorowicz-Buniak, J., additional, Abraham, D. J., additional, Denton, C., additional, Stratton, R., additional, Bayley, R., additional, Kite, K. A., additional, Clay, E., additional, Smith, J. P., additional, Kitas, G. D., additional, Buckley, C., additional, Young, S. P., additional, Ye, L., additional, Zhang, L., additional, Goodall, J., additional, Gaston, H., additional, Xu, H., additional, Lutalo, P. M., additional, Zhao, Y., additional, Meng Choong, L., additional, Sangle, S., additional, Spencer, J., additional, D'Cruz, D., additional, Rysnik, O. J., additional, McHugh, K., additional, Bowness, P., additional, Rump-Goodrich, L., additional, Mattey, D., additional, Kehoe, O., additional, Middleton, J., additional, Cartwright, A., additional, Schmutz, C., additional, Askari, A., additional, Gardner, D. H., additional, Jeffery, L. E., additional, Raza, K., additional, Sansom, D. M., additional, Fitzpatrick, M., additional, Wallace, G., additional, Young, S., additional, Shaw, J., additional, Hatano, H., additional, Cauli, A., additional, Giles, J. L., additional, Mathieu, A., additional, Kollnberger, S., additional, Webster, S., additional, Ellis, L., additional, O'Brien, L. M., additional, Fitzmaurice, T. J., additional, Nazeer Moideen, A., additional, Evans, L., additional, Osgood, L., additional, Williams, A., additional, Jones, S., additional, Thomas, C., additional, O'Donnell, V., additional, Nowell, M., additional, Ouboussad, L., additional, Savic, S., additional, Dickie, L. J., additional, Hintze, J., additional, Wong, C. H., additional, Cook, G. P., additional, Buch, M., additional, Emery, P., additional, McDermott, M. F., additional, Hardcastle, S. A., additional, Gregson, C. L., additional, Deere, K., additional, Davey Smith, G., additional, Dieppe, P., additional, Tobias, J. H., additional, Dennison, E., additional, Edwards, M., additional, Bennett, J., additional, Coggon, D., additional, Palmer, K., additional, Cooper, C., additional, McWilliams, D., additional, Young, A., additional, Kiely, P. D., additional, Walsh, D., additional, Taylor, H. J., additional, Harding, I., additional, Hutchinson, J., additional, Nelson, I., additional, Blom, A., additional, Tobias, J., additional, Clark, E., additional, Parker, J., additional, Bukhari, M., additional, Jayakumar, K., additional, Kiely, P., additional, Diffin, J., additional, Lunt, M., additional, Marshall, T., additional, Chipping, J., additional, Symmons, D., additional, Verstappen, S., additional, Bluett, J., additional, Bowes, J., additional, Ho, P., additional, McHugh, N., additional, Buden, D., additional, Fitzgerald, O., additional, Barton, A., additional, Glossop, J. R., additional, Nixon, N. B., additional, Emes, R. D., additional, Dawes, P. T., additional, Farrell, W. E., additional, Mattey, D. L., additional, Scott, I. C., additional, Steer, S., additional, Seegobin, S., additional, Hinks, A. M., additional, Eyre, S., additional, Morgan, A., additional, Wilson, A. G., additional, Hocking, L., additional, Wordsworth, P., additional, Worthington, J., additional, Cope, A., additional, Lewis, C. M., additional, Guerra, S., additional, Ahmed, B. A., additional, Abraham, D., additional, Fonseca, C., additional, Robinson, J., additional, Taylor, J., additional, Haroon Rashid, L., additional, Flynn, E., additional, Isaacs, J., additional, Barrett, J. H., additional, Kingston, B., additional, Ahmed, M., additional, Kirwan, J. R., additional, Marshall, R., additional, Chapman, K., additional, Pearson, R., additional, Heycock, C., additional, Kelly, C., additional, Rynne, M., additional, Saravanan, V., additional, Hamilton, J., additional, Saeed, A., additional, Coughlan, R., additional, Carey, J. J., additional, Farah, Z., additional, Matthews, W., additional, Bell, C., additional, Petford, S., additional, Tibbetts, L.-M., additional, Douglas, K. M. J., additional, Holden, W., additional, Ledingham, J., additional, Fletcher, M., additional, Winfield, R., additional, Price, Z., additional, Mackay, K., additional, Dixon, C., additional, Oppong, R., additional, Jowett, S., additional, Nicholls, E., additional, Whitehurst, D., additional, Hill, S., additional, Hammond, A., additional, Hay, E., additional, Dziedzic, K., additional, Righetti, C., additional, Lebmeier, M., additional, Manning, V. L., additional, Hurley, M., additional, Scott, D. L., additional, Choy, E., additional, Bearne, L., additional, Nikiphorou, E., additional, Morris, S., additional, James, D., additional, Wong, E. C., additional, Long, J., additional, Fletcher, A., additional, Holmes, S., additional, Hockey, P., additional, Abbas, M., additional, Chattopadhyay, C., additional, Flint, J., additional, Gayed, M., additional, Schreiber, K., additional, Arthanari, S., additional, Nisar, M., additional, Khamashta, M., additional, Gordon, C., additional, Giles, I., additional, Robson, J., additional, Kiran, A., additional, Maskell, J., additional, Arden, N., additional, Hutchings, A., additional, Emin, A., additional, Culliford, D., additional, Dasgupta, B., additional, Hamilton, W., additional, Luqmani, R., additional, Jethwa, H., additional, Rowczenio, D., additional, Trojer, H., additional, Russell, T., additional, Loeffler, J., additional, Hawkins, P., additional, Lachmann, H., additional, Verma, I., additional, Syngle, A., additional, Krishan, P., additional, Garg, N., additional, McGowan, S. P., additional, Gerrard, D. T., additional, Chinoy, H., additional, Ollier, W. E., additional, Cooper, R. G., additional, Lamb, J. A., additional, Taborda, L., additional, Correia Azevedo, P., additional, Isenberg, D., additional, Leyland, K. M., additional, Judge, A., additional, Hunter, D., additional, Hart, D., additional, Javaid, M. K., additional, Edwards, M. H., additional, Litwic, A. E., additional, Jameson, K. A., additional, Deeg, D., additional, Cushnaghan, J., additional, Aihie Sayer, A., additional, Jagannath, D., additional, Parsons, C., additional, Stoppiello, L., additional, Mapp, P., additional, Ashraf, S., additional, Wilson, D., additional, Hill, R., additional, Scammell, B., additional, Wenham, C., additional, Shore, P., additional, Hodgson, R., additional, Grainger, A., additional, Aaron, J., additional, Hordon, L., additional, Conaghan, P., additional, Bar-Ziv, Y., additional, Beer, Y., additional, Ran, Y., additional, Benedict, S., additional, Halperin, N., additional, Drexler, M., additional, Mor, A., additional, Segal, G., additional, Lahad, A., additional, Haim, A., additional, Rath, U., additional, Morgensteren, D. M., additional, Salai, M., additional, Elbaz, A., additional, Vasishta, V. G., additional, Derrett-Smith, E., additional, Hoyles, R., additional, Khan, K., additional, Ezeonyeji, A., additional, Takhar, G., additional, Ong, V., additional, Loughrey, L., additional, Bissell, L.-A., additional, Hensor, E., additional, Abignano, G., additional, Redmond, A., additional, Del Galdo, F., additional, Hall, F. C., additional, Malaviya, A., additional, Baker, S., additional, Furlong, A., additional, Mitchell, A., additional, Godfrey, A. L., additional, Ruddlesden, M., additional, Hadjinicolaou, A., additional, Hughes, M., additional, Moore, T., additional, O'Leary, N., additional, Tracey, A., additional, Ennis, H., additional, Dinsdale, G., additional, Roberts, C., additional, Herrick, A., additional, Denton, C. P., additional, Guillevin, L., additional, Hunsche, E., additional, Rosenberg, D., additional, Schwierin, B., additional, Scott, M., additional, Krieg, T., additional, Anderson, M., additional, Matucci-Cerinic, M., additional, Alade, R., additional, Xu, S., additional, Nihtyanova, S., additional, Clark, K. E., additional, Tam, F. W. K., additional, Unwin, R., additional, Stratton, R. J., additional, Schreiber, B., additional, Seng Edwin Lim, C., additional, Corsiero, E., additional, Sutcliffe, N., additional, Wardemann, H., additional, Pitzalis, C., additional, Bombardieri, M., additional, Tahir, H., additional, Donnelly, S., additional, Greenwood, M., additional, Smith, T. O., additional, Easton, V., additional, Bacon, H., additional, Jerman, E., additional, Armon, K., additional, Poland, F., additional, Macgregor, A., additional, van der Heijde, D., additional, Sieper, J., additional, Elewaut, D., additional, Pangan, A. L., additional, Nguyen, D., additional, Badenhorst, C., additional, Kirby, S., additional, White, D., additional, Harrison, A., additional, Garcia, J. A., additional, Stebbings, S., additional, MacKay, J. W., additional, Aboelmagd, S., additional, Gaffney, K., additional, Deodhar, A., additional, Braun, J., additional, Mack, M., additional, Hsu, B., additional, Gathany, T., additional, Han, C., additional, Inman, R. D., additional, Cooper-Moss, N., additional, Packham, J., additional, Strauss, V., additional, Freeston, J. E., additional, Coates, L., additional, Nam, J., additional, Moverley, A. R., additional, Helliwell, P., additional, Wakefield, R., additional, Mease, P., additional, Fleischmann, R., additional, Wollenhaupt, J., additional, Kielar, D., additional, Woltering, F., additional, Stach, C., additional, Hoepken, B., additional, Arledge, T., additional, Gladman, D., additional, Coteur, G., additional, Kavanaugh, A., additional, Purcaru, O., additional, McInnes, I., additional, Gottlieb, A. B., additional, Puig, L., additional, Rahman, P., additional, Ritchlin, C., additional, Li, S., additional, Wang, Y., additional, Mendelsohn, A., additional, Doyle, M., additional, Tillett, W., additional, Jadon, D., additional, Shaddick, G., additional, Cavill, C., additional, Robinson, G., additional, Sengupta, R., additional, Korendowych, E., additional, de Vries, C., additional, Thomas, R. C., additional, Shuto, T., additional, Busquets-Perez, N., additional, Marzo-Ortega, H., additional, McGonagle, D., additional, Richards, G., additional, Bingham, S., additional, John Hamlin, P., additional, Adshead, R., additional, Cambridge, S., additional, Suppiah, P., additional, Cullinan, M., additional, Nolan, A., additional, Thompson, W. M., additional, Mathieson, H. R., additional, Mackie, S. L., additional, Bryer, D., additional, Krutikov, M., additional, Gray, L., additional, Bruce, E., additional, Keat, A., additional, Innes, W., additional, Pandit, R., additional, Kay, L., additional, Lapshina, S., additional, Myasoutova, L., additional, Erdes, S., additional, Wallis, D., additional, Waldron, N., additional, Thorne, I., additional, Harris, C., additional, Vohra, K., additional, Khinchi, D., additional, Kaur, L., additional, Jones, A., additional, Harrison, N., additional, Harris, D., additional, Jones, T., additional, Rees, J., additional, Bennett, A., additional, Fazal, S., additional, Tugnet, N., additional, Barkham, N., additional, Basu, N., additional, McClean, A., additional, Harper, L., additional, Amft, E. N., additional, Dhaun, N., additional, Luqmani, R. A., additional, Little, M. A., additional, Jayne, D. R., additional, Flossmann, O., additional, McLaren, J., additional, Kumar, V., additional, Reid, D. M., additional, Macfarlane, G. J., additional, Jones, G., additional, Yates, M., additional, Watts, R. A., additional, Igali, L., additional, Mukhtyar, C., additional, Doll, H., additional, Yew, S., additional, Suppiah, R., additional, Hoglund, P., additional, Jayne, D., additional, Westman, K., additional, Win Maw, W., additional, Patil, P., additional, Williams, M., additional, Adizie, T., additional, Christidis, D., additional, Borg, F., additional, Robertson, A., additional, Croft, A. P., additional, Smith, S., additional, Carr, S., additional, Youssouf, S., additional, Salama, A., additional, Pusey, C., additional, and Morgan, M., additional

Published
2013
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12. THE URINARY EXCRETION OF 17-KETOSTEROIDS BY MEN UNDER FIELD CONDITIONS IN EXTREME COLD

Author

ARMY MEDICAL RESEARCH LAB FORT KNOX KY, Osgood, L. E., Zimmerman, W. J., King, E. W., Diffley, G. H., ARMY MEDICAL RESEARCH LAB FORT KNOX KY, Osgood, L. E., Zimmerman, W. J., King, E. W., and Diffley, G. H.

Abstract

Tests were conducted to determine the excretion of 17-ketosteroids on a group of seven subjects participating in two bivouac exercises, first under conditions of a temperate climate, and later under arctic conditions, which were so designed as to be similar except for the factor of extreme cold. When the excretion of 17-ketosteroids by seven healthy soldiers under field conditions in a temperate climate was compared with their excretion of these substances under field conditions in extreme cold, no significant changes were noted. The determination of the excretion of 17-ketosteroids in the urine did not indicate a stress due to cold under the circumstances described in this report.

Published
1949

13. Visitor account, L. Osgood, 1839 June 28

Author

Osgood, L. and Osgood, L.

Abstract

Autograph document, 17 pages, put together in book form, subheading "Mt. Vernon in 1839 by a Native of this Country," dated at Washington, D.C.

17. Building and measuring infrastructure and capacity for community health assessment and health improvement planning in Florida.

Author

Abarca C, Grigg CM, Steele JA, Osgood L, and Keating H

Subjects
Data Collection, Florida, Internet, Local Government, Organizational Case Studies, Public Health, Community Health Planning organization & administration, Needs Assessment, Program Development
Abstract

Background: COMPASS (Comprehensive Assessment, Strategic Success) is the Florida Department of Health's community health assessment and health improvement planning initiative. Since 2002, COMPASS built state and county health department infrastructure to support a comprehensive, systematic, and integrated approach to community health assessment and planning., Methods: To assess the capacity of Florida's 67 county health departments (CHDs) to conduct community health assessment and planning and to identify training and technical assistance needs, COMPASS surveyed the CHDs using a Web-based instrument annually from 2004 through 2008., Findings: Response rate to the survey was 100 percent annually. In 2007, 96 percent of CHDs reported conducting assessment and planning within the past 3 years; 74 percent used the MAPP (Mobilizing for Action through Planning and Partnerships) framework. Progress was greater for the organizational and assessment phases of the MAPP-based work; only 10 CHDs had identified strategic priorities in 2007, and even fewer had implemented strategies for improving health. In 2007, the most frequently requested types of training were measuring success, developing goals and action plans, and using qualitative data; technical assistance was most frequently requested for program evaluation and writing community health status reports., Conclusions: Florida's CHDs have increased their capacity to conduct community health assessment and planning. Questions remain about sustaining these gains with limited resources.

Published
2009
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18. Galanin attenuates retention of one-trial reward learning.

Author

Malin DH, Novy BJ, Lett-Brown AE, Plotner RE, May BT, Radulescu SJ, Crothers MK, Osgood LD, and Lake JR

Subjects
Animals, Galanin, Injections, Intraventricular, Male, Memory drug effects, Rats, Rats, Inbred Strains, Reward, Discrimination Learning drug effects, Neuropeptides pharmacology, Peptides pharmacology
Abstract

Galanin is a neuropeptide that coexists with acetylcholine in the septohippocampal pathway. Galanin appears to have a negative modulating influence on cholinergic transmission, suggesting that it might interfere with memory formation on a one-trial discriminative reward learning task. The apparatus was a starburst maze with five radiating alleys, one an ascending baited alley. The subjects were 38 two to three month old Sprague-Dawley rats cannulated in the body of the lateral ventricles and deprived to 80% of initial weight. Ten rats were infused i.c.v. over six mins. with 8 micrograms galanin in 24 microliters saline and 10 with saline alone. Twenty mins. after completion of infusion, each rat was placed in the maze and observed under "blind" conditions for number of errors (blind alleys entered) and latency to reach reward. Each rat's speed score was 100 sec./latency. One day later, each rat was retested in the maze. Each rat's retention scores were its decrease in errors and increase in speed between the single training trial and the retention trial. Galanin infused rats showed significantly less retention by both measures. In a second experiment, either the same dose of galanin or saline alone was infused 20 mins. before the retention trial. There was no significant effect, suggesting that galanin may interfere with memory formation rather than memory retrieval or task performance.

Published
1992
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19. Methanesulfonyl fluoride enhances one-trial reward learning in mid-aged rats.

Author

Malin DH, Toups PJ, Osgood LD, Fowler DE, Hunter CL, Arcangeli KR, and Moss DE

Subjects
Aging psychology, Animals, Brain enzymology, Cholinesterases metabolism, Discrimination Learning drug effects, Discrimination Learning physiology, Male, Memory drug effects, Rats, Rats, Inbred Strains, Reward, Stimulation, Chemical, Cholinesterase Inhibitors pharmacology, Learning drug effects, Sulfones pharmacology
Abstract

In previous studies, 18-month-old rats have shown no significant retention 24 hours after the single acquisition trial in a one-trial discriminative reward learning task. In the present study, ten 18-month-old rats pretreated with 0.5 mg/kg MSF IP showed significantly better retention in terms of speed and errors than eleven 18-month-old rats pretreated with injection vehicle alone. However, twelve two-three-month-old rats pretreated with the same dose of MSF failed to show better retention than eleven two-three-month-old rats pretreated with vehicle alone.

Published
1991
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