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We provide a technique for resolving intermediate-separation binaries stars with medium-sized telescopes (i.e. diameter less than or equal to 2.5 m) at wavelengths around 825 nm in the super-resolution range (i.e. below the limit defined by the Rayleigh criterion). We combined two well-known algorithms that have been applied to reduce the halo in lucky imaging observations: COvariancE of Lucky Images (COELI) and the Lucky Imaging Speckle Suppression Algorithm (LISSA). We reviewed the fundamentals of both algorithms and describe a new technique called Lucky Imaging Super resolution Technique (LIST), which is optimized for peak highlighting within the first ring of the Airy pattern. To validate the technique, we carried out several observing campaigns of well-known binary stars with FastCam on the 1.52 m TCS and 2.56 m NOT. The projected angular separation between objects was resolved by applying LIST with a result below 0.15". It can go down to approximately 0.05", given the limitations of the detector plate scale. This is, to our knowledge, the first time that binary companions with such small angular separations have been detected using only lucky imaging at optical wavelengths. The average accuracy achieved for the angular separation measurement is 16 mas with NOT and is 20 mas with TCS. The average accuracy obtained for the position angle measurement is $9.5^o$ for NOT and $11^o$ for TCS. We also made an attempt to measure the relative brightnesses of the binary components, obtaining results that are compatible with literature measurements. Lucky imaging, in combination with speckle suppression and a covariance analysis, can allow the resolution of multiple point sources below the diffraction limit of 2-m class telescopes. However, it should be noted that measurements in the super-resolution regime are less sensitive than those above the first Airy ring., Comment: Accepted for publication in Astronomy and Astrophysics. Abstract abbreviated to comply with arXiv requirements

Background: The worst outcomes of diabetic retinopathy (DR) can be prevented by implementing DR screening programs assisted by AI. At the University Hospital of Navarre (HUN), Spain, general practitioners (GPs) grade fundus images in an ongoing DR screening program, referring to a second screening level (ophthalmologist) target patients. Methods: After collecting their requirements, HUN decided to develop a custom AI tool, called NaIA-RD, to assist their GPs in DR screening. This paper introduces NaIA-RD, details its implementation, and highlights its unique combination of DR and retinal image quality grading in a single system. Its impact is measured in an unprecedented before-and-after study that compares 19,828 patients screened before NaIA-RD's implementation and 22,962 patients screened after. Results: NaIA-RD influenced the screening criteria of 3/4 GPs, increasing their sensitivity. Agreement between NaIA-RD and the GPs was high for non-referral proposals (94.6% or more), but lower and variable (from 23.4\% to 86.6%) for referral proposals. An ophthalmologist discarded a NaIA-RD error in most of contradicted referral proposals by labeling the 93% of a sample of them as referable. In an autonomous setup, NaIA-RD would have reduced the study visualization workload by 4.27 times without missing a single case of sight-threatening DR referred by a GP. Conclusion: DR screening was more effective when supported by NaIA-RD, which could be safely used to autonomously perform the first level of screening. This shows how AI devices, when seamlessly integrated into clinical workflows, can help improve clinical pathways in the long term.

In the ELTs era, where the need for versatile and innovative solutions to produce very high spatial resolution images has become a major issue, the search of synergies with other science fields seems a logic step. One of the considered alternatives to reach high-resolution images is the use of several frames of the same target, this approach is known as fusion Super-Resolution in the state of the art. Here, we propose the use of the super-resolution techniques based on structural similarity and initially developed for submarine environments. Accordingly, innovative algorithms are implemented in order to process the science images from an Adaptive Optics system to obtain diffraction-limited images in the optical wavelengths., Comment: 4 pages, 3 figures

The TP3-WFS (Two Pupil Plane Positions Wavefront Sensor) is, to the best of the authors' knowledge, the first physical implementation of the geometrical wavefront reconstruction algorithm that has been tested in a telescope as part of an actual AO-enabled instrument. The main advantage of this algorithm is that it theoretically provides a fairly good reconstruction accuracy even under very low levels of light, in the order of a few hundreds of photons. This paper presents the first control-related results obtained at the William Herschel Telescope (WHT). Such results demonstrate the feasibility of this novel WFS as part of a real-time AO control loop., Comment: 4 pages, 3 figures

As a consequence of the evolution in the design and of the modularity of its components, AOLI for the William Herschel Telescope (WHT 4.2m) is much smaller and more efficient than its previous designs. This success has leaded us to plan to condense it even more to get a portable and easy to integrate system, ALIOLI (Adaptive and Lucky Imaging Optics Lightweight Instrument). It consists of a DM+WFS module with a lucky imaging science camera attached. ALIOLI is an AO instrument for the 1-2m class telescopes which will also be used as on-sky testbench for AO developments. Here we describe the setup to be installed at the 1.5m Telescopio Carlos S\'anchez (TCS) at the Spanish Observatorio del Teide (Tenerife, Canary Islands)., Comment: 4 pages, 5 figures, conference

Here we present the Adaptive Optics Lucky Imager (AOLI), a state-of-the-art instrument which makes use of two well proved techniques, Lucky Imaging (LI) and Adaptive Optics (AO), to deliver diffraction limited imaging at visible wavelengths, 20 mas, from ground-based telescopes. Thanks to its revolutionary TP3-WFS, AOLI shall have the capability of using faint reference stars. In the extremely-big telescopes era, the combination of techniques and the development of new WFS systems seems the clue key for success. We give details of the integration and verification phases explaining the defiance that we have faced and the innovative and versatile solutions for each of its subsystems that we have developed, providing also very fresh results after its first fully-working observing run at the William Herschel Telescope (WHT)., Comment: 6 pages, 6 figures, conference. arXiv admin note: text overlap with arXiv:1703.09354, arXiv:1608.04806

We report the development of a 4-color simultaneous camera for the 1.52~m Telescopio Carlos S\'anchez (TCS) in the Teide Observatory, Canaries, Spain. The new instrument, named MuSCAT2, has a capability of 4-color simultaneous imaging in $g$ (400--550 nm), $r$ (550--700 nm), $i$ (700--820 nm), and $z_s$ (820--920 nm) bands. MuSCAT2 equips four 1024$\times$1024 pixel CCDs, having a field of view of 7.4$\times$7.4 arcmin$^2$ with a pixel scale of 0.44 arcsec per pixel. The principal purpose of MuSCAT2 is to perform high-precision multi-color exoplanet transit photometry. We have demonstrated photometric precisions of 0.057%, 0.050%, 0.060%, and 0.076% as root-mean-square residuals of 60~s binning in $g$, $r$, $i$ and $z_s$ bands, respectively, for a G0 V star WASP-12 ($V=11.57\pm0.16$). MuSCAT2 has started science operations since January 2018, with over 250 telescope nights per year. MuSCAT2 is expected to become a reference tool for exoplanet transit observations, and will substantially contribute to the follow-up of the TESS and PLATO space missions., Comment: 21 pages, 13 figures, 5 tables, Published in JATIS on Dec 27, 2018, the open access article is available http://dx.doi.org/10.1117/1.JATIS.5.1.015001

In the framework of the Gravitational LENses and DArk MAtter (GLENDAMA) project, we present a database of nine gravitationally lensed quasars (GLQs) that have two or four images brighter than $r$ = 20 mag and are located in the northern hemisphere. This new database consists of a rich variety of follow-up observations included in the GLENDAMA global archive, which is publicly available online and contains 6557 processed astronomical frames of the nine lens systems over the period 1999$-$2016. In addition to the GLQs, our archive also incorporates binary quasars, accretion-dominated radio-loud quasars, and other objects, where about 50% of the non-GLQs were observed as part of a campaign to identify GLQ candidates. Most observations of GLQs correspond to an ongoing long-term macro-programme with 2$-$10 m telescopes at the Roque de los Muchachos Observatory, and these data provide information on the distribution of dark matter at all scales. We outline some previous results from the database, and we additionally obtain new results for several GLQs that update the potential of the tool for astrophysical studies., Comment: Accepted to A&A; 32 pages. Tables 4-6, 8-11 and 13-16 are only available in electronic form at the CDS and https://grupos.unican.es/glendama/LQLM_results.htm

The Adaptive Optics Lucky Imager (AOLI) is a new instrument designed to combine adaptive optics (AO) and lucky imaging (LI) techniques to deliver high spatial resolution in the visible, 20 mas, from ground-based telescopes. Here we present details of the integration and verification phases explaining the defiance that we have faced and the innovative and versatile solution of modular integration for each of its subsystems that we have developed. Modularity seems a clue key for opto-mechanical integration success in the extremely-big telescopes era. We present here the very fresh preliminary results after its first fully-working observing run on the WHT., Comment: 5 pages, 3 figures

AOLI (Adaptive Optics Lucky Imager) is a state-of-art instrument that combines adaptive optics (AO) and lucky imaging (LI) with the objective of obtaining diffraction limited images in visible wavelength at mid- and big-size ground-based telescopes. The key innovation of AOLI is the development and use of the new TP3-WFS (Two Pupil Plane Positions Wavefront Sensor). The TP3-WFS, working in visible band, represents an advance over classical wavefront sensors such as the Shack-Hartmann WFS (SH-WFS) because it can theoretically use fainter natural reference stars, which would ultimately provide better sky coverages to AO instruments using this newer sensor. This paper describes the software, algorithms and procedures that enabled AOLI to become the first astronomical instrument performing real-time adaptive optics corrections in a telescope with this new type of WFS, including the first control-related results at the William Herschel Telescope (WHT)., Comment: 15 pages, 18 figures, Accepted 2017 January 27

The FastCam instrument platform, jointly developed by the IAC and the UPCT, allows, in real-time, acquisition, selection and storage of images with a resolution that reaches the diffraction limit of medium-sized telescopes. FastCam incorporates a specially designed software package to analyse series of tens of thousands of images in parallel with the data acquisition at the telescope. Wide FastCam is a new instrument that, using the same software for data acquisition, does not look for lucky imaging but fast observations in a much larger field of view. Here we describe the commissioning process and first observations with Wide FastCam at the Telescopio Carlos S\'anchez (TCS) in the Observatorio del Teide., Comment: 7 pages, 8 figures, Proc. SPIE. 9908, Ground-based and Airborne Instrumentation for Astronomy VI, 99082O. (August 09, 2016)

The Adaptive Optics Lucky Imager, AOLI, is an instrument developed to deliver the highest spatial resolution ever obtained in the visible, 20 mas, from ground-based telescopes. In AOLI a new philosophy of instrumental prototyping has been applied, based on the modularization of the subsystems. This modular concept offers maximum flexibility regarding the instrument, telescope or the addition of future developments., Comment: 10 pages, 8 figures, Proc. SPIE 9908, Ground-based and Airborne Instrumentation for Astronomy VI, 99082Z (August 9, 2016)

We present eight monitoring seasons of the four brightest images of the gravitational lens SDSS J1004+4112 observed between December 2003 and October 2010. Using measured time delays for the images A, B and C and the model predicted time delay for image D we have removed the intrinsic quasar variability, finding microlensing events of about 0.5 and 0.7 mag of amplitude in the images C and D. From the statistics of microlensing amplitudes in images A, C, and D, we have inferred the half-light radius (at {\lambda} rest = 2407 {\AA}) for the accretion disk using two different methods, $R_{1/2}=8.7^{+18.5}_{-5.5} \sqrt{M/0.3 M_\odot}$ (histograms product) and $R_{1/2} = 4.2^{+3.2}_{-2.2} \sqrt{M/0.3 M_\odot}$ light-days ($\chi^2$). The results are in agreement within uncertainties with the size predicted from the black hole mass in SDSS J1004+4112 using the thin disk theory.

The combination of Lucky Imaging with a low order adaptive optics system was demonstrated very successfully on the Palomar 5m telescope nearly 10 years ago. It is still the only system to give such high-resolution images in the visible or near infrared on ground-based telescope of faint astronomical targets. The development of AOLI for deployment initially on the WHT 4.2 m telescope in La Palma, Canary Islands, will be described in this paper. In particular, we will look at the design and status of our low order curvature wavefront sensor which has been somewhat simplified to make it more efficient, ensuring coverage over much of the sky with natural guide stars as reference object. AOLI uses optically butted electron multiplying CCDs to give an imaging array of 2000 x 2000 pixels., Comment: 7 pages, 5 figures, SPIE conference 9908, Edinburgh,June 2016. arXiv admin note: substantial text overlap with arXiv:1408.0117, arXiv:1207.4065

We report high spatial resolution i' band imaging of the multiple T Tauri system LkH$\alpha$ 262/LkH$\alpha$ 263 obtained during the first commissioning period of the Adaptive Optics Lucky Imager (AOLI) at the 4.2 m William Herschel Telescope, using its Lucky Imaging mode. AOLI images have provided photometry for each of the two components LkH$\alpha$ 263 A and B (0.41 arcsec separation) and marginal evidence for an unresolved binary or a disc in LkH$\alpha$ 262. The AOLI data combined with previously available and newly obtained optical and infrared imaging show that the three components of LkH$\alpha$ 263 are co-moving, that there is orbital motion in the AB pair, and, remarkably, that LkH$\alpha$ 262-263 is a common proper motion system with less than 1 mas/yr relative motion. We argue that this is a likely five-component gravitationally bounded system. According to BT-settl models the mass of each of the five components is close to 0.4 M$_{\odot}$ and the age is in the range 1-2 Myr. The presence of discs in some of the components offers an interesting opportunity to investigate the formation and evolution of discs in the early stages of multiple very low-mass systems. In particular, we provide tentative evidence that the disc in 263C could be coplanar with the orbit of 263AB., Comment: 11 pages, 7 figures, Accepted 2016 May 4

In this paper we present the Adaptive Optics Lucky Imager (AOLI), a state-of-the-art instrument which makes use of two well proved techniques for extremely high spatial resolution with ground-based telescopes: Lucky Imaging (LI) and Adaptive Optics (AO). AOLI comprises an AO system, including a low order non-linear curvature wavefront sensor together with a 241 actuators deformable mirror, a science array of four 1024x1024 EMCCDs, allowing a 120x120 down to 36x36 arcseconds field of view, a calibration subsystem and a powerful LI software. Thanks to the revolutionary WFS, AOLI shall have the capability of using faint reference stars ({\it I\/} $\sim$ 16.5-17.5), enabling it to be used over a much wider part of the sky than with common Shack-Hartmann AO systems. This instrument saw first light in September 2013 at William Herschel Telescope. Although the instrument was not complete, these commissioning demonstrated its feasibility, obtaining a FWHM for the best PSF of 0.151$\pm$0.005 arcsec and a plate scale of 55.0$\pm$0.3 mas/pixel. Those observations served us to prove some characteristics of the interesting multiple T Tauri system LkH$\alpha$ 262-263, finding it to be gravitationally bounded. This interesting multiple system mixes the presence of proto-planetary discs, one proved to be double, and the first-time optically resolved pair LkH$\alpha$ 263AB (0.42 arcsec separation)., Comment: 6 pages, 4 figures

The Liverpool Telescope is one of the world's premier facilities for time domain astronomy. The time domain landscape is set to radically change in the coming decade, with surveys such as LSST providing huge numbers of transient detections on a nightly basis; transient detections across the electromagnetic spectrum from other facilities such as SVOM, SKA and CTA; and the era of `multi-messenger astronomy', wherein events are detected via non-electromagnetic means, such as gravitational wave emission. We describe here our plans for Liverpool Telescope 2: a new robotic telescope designed to capitalise on this new era of time domain astronomy. LT2 will be a 4-metre class facility co-located with the LT at the Observatorio del Roque de Los Muchachos on the Canary island of La Palma. The telescope will be designed for extremely rapid response: the aim is that the telescope will take data within 30 seconds of the receipt of a trigger from another facility. The motivation for this is twofold: firstly it will make it a world-leading facility for the study of fast fading transients and explosive phenomena discovered at early times. Secondly, it will enable large-scale programmes of low-to-intermediate resolution spectral classification of transients to be performed with great efficiency. In the target-rich environment of the LSST era, minimising acquisition overheads will be key to maximising the science gains from any follow-up programme. The telescope will have a diverse instrument suite which is simultaneously mounted for automatic changes, but it is envisaged that the primary instrument will be an intermediate resolution, optical/infrared spectrograph for scientific exploitation of transients discovered with the next generation of synoptic survey facilities. In this paper we outline the core science drivers for the telescope, and the requirements for the optical and mechanical design., Comment: 53 pages including 7 figures and 1 table. Accepted by Experimental Astronomy. First revision modified in light of comments from the anonymous referee. This revision fixed some minor typographical errors introduced in the first revision

Lucky Imaging combined with a low order adaptive optics system has given the highest resolution images ever taken in the visible or near infrared of faint astronomical objects. This paper describes a new instrument that has already been deployed on the WHT 4.2m telescope on La Palma, with particular emphasis on the optical design and the predicted system performance. A new design of low order wavefront sensor using photon counting CCD detectors and multi-plane curvature wavefront sensor will allow virtually full sky coverage with faint natural guide stars. With a 2 x 2 array of 1024 x 1024 photon counting EMCCDs, AOLI is the first of the new class of high sensitivity, near diffraction limited imaging systems giving higher resolution in the visible from the ground than hitherto been possible from space., Comment: 8 pages, 6 figures, SPIE conference 9147, paper 64, Montreal 2014

We present twelve years of monitoring of the gravitational lens Q0142-100 from the Teide Observatory. The data, taken from 1999 to 2010, comprise 105 observing nights with the IAC80 telescope. The application of the delta2-method to the dataset leads to a value of the time delay between both components of the system of 72+/-22 days (68 per cent confidence level), consistent within the uncertainties with the latest previous results. With this value in mind a possible microlensing event is detected in Q0142-100., Comment: 12 figures. Accepted for publication in The Astrophysical Journal

The highest resolution images ever taken in the visible were obtained by combining Lucky Imaging and low order adaptive optics. This paper describes a new instrument to be deployed on the WHT 4.2m and GTC 10.4 m telescopes on La Palma, with particular emphasis on the optical design and the expected system performance. A new design of low order wavefront sensor using photon counting CCD detectors and multi-plane curvature wavefront sensor will allow dramatically fainter reference stars to be used, allowing virtually full sky coverage with a natural guide star. This paper also describes a significant improvements in the efficiency of Lucky Imaging, important advances in wavefront reconstruction with curvature sensors and the results of simulations and sensitivity limits. With a 2 x 2 array of 1024 x 1024 photon counting EMCCDs, AOLI is likely to be the first of the new class of high sensitivity, near diffraction limited imaging systems giving higher resolution in the visible from the ground than hitherto been possible from space., Comment: SPIE vol 8446, 2012

The Adaptive Optics Lucky Imager (AOLI) is a new instrument under development to demonstrate near diffraction limited imaging in the visible on large ground-based telescopes. We present the adaptive optics system being designed for the instrument comprising a large stroke deformable mirror, fixed component non-linear curvature wavefront sensor and photon-counting EMCCD detectors. We describe the optical design of the wavefront sensor where two photoncounting CCDs provide a total of four reference images. Simulations of the optical characteristics of the system are discussed, with their relevance to low and high order AO systems. The development and optimisation of high-speed wavefront reconstruction algorithms are presented. Finally we discuss the results of simulations to demonstrate the sensitivity of the system., Comment: 10 pages. To be published in Proc SPIE 8447: Adaptive Optics Systems III

We present high-resolution I-band imaging of the core of the globular cluster M15 obtained at the 2.5 m Nordic Optical Telescope with FastCam, a low readout noise L3CCD based instrument. Short exposure times (30 ms) were used to record 200000 images (512 x 512 pixels each) over a period of 2 hours 43 min. The lucky imaging technique was then applied to generate a final image of the cluster centre with FWHM ~ 0".1 and 13" x 13" FoV. We obtained a catalogue of objects in this region with a limiting magnitude of I=19.5. I-band photometry and astrometry are reported for 1181 stars. This is the deepest I-band observation of the M15 core at this spatial resolution. Simulations show that crowding is limiting the completeness of the catalogue. At shorter wavelengths, a similar number of objects has been reported using HST/WFPC observations of the same field. The cross-match with the available HST catalogues allowed us to produce colour-magnitude diagrams where we identify new Blue Straggler star candidates and previously known stars of this class., Comment: 11 pages, 15 figures. Accepted for publication in Monthly Notices of the Royal Astronomical Society

The potential of combining Adaptive Optics (AO) and Lucky Imaging (LI) to achieve high precision astrometry and differential photometry in the optical is investigated by conducting observations of the close 0\farcs1 brown dwarf binary GJ569Bab. We took 50000 $I$-band images with our LI instrument FastCam attached to NAOMI, the 4.2-m William Herschel Telescope (WHT) AO facility. In order to extract the most of the astrometry and photometry of the GJ569Bab system we have resorted to a PSF fitting technique using the primary star GJ569A as a suitable PSF reference which exhibits an $I$-band magnitude of $7.78\pm0.03$. The AO+LI observations at WHT were able to resolve the binary system GJ569Bab located at $4\farcs 92 \pm 0\farcs05$ from GJ569A. We measure a separation of $98.4 \pm 1.1$ mas and $I$-band magnitudes of $13.86 \pm 0.03$ and $14.48 \pm 0.03$ and $I-J$ colors of 2.72$\pm$0.08 and 2.83$\pm$0.08 for the Ba and Bb components, respectively. Our study rules out the presence of any other companion to GJ569A down to magnitude I$\sim$ 17 at distances larger than 1\arcsec. The $I-J$ colors measured are consistent with M8.5-M9 spectral types for the Ba and Bb components. The available dynamical, photometric and spectroscopic data are consistent with a binary system with Ba being slightly (10-20%) more massive than Bb. We obtain new orbital parameters which are in good agreement with those in the literature., Comment: 13 pages, 9 figures, 7 tables, in press in MNRAS

High contrast imaging at optical wavelengths is limited by the modest correction of conventional near-IR optimized AO systems.We take advantage of new fast and low-readout-noise detectors to explore the potential of fast imaging coupled to post-processing techniques to detect faint companions to stars at small separations. We have focused on I-band direct imaging of the previously detected brown dwarf binary HD130948BC,attempting to spatially resolve the L2+L2 benchmark system. We used the Lucky-Imaging instrument FastCam at the 2.5-m Nordic Telescope to obtain quasi diffraction-limited images of HD130948 with ~0.1" resolution.In order to improve the detectability of the faint binary in the vicinity of a bright (I=5.19 \pm 0.03) solar-type star,we implemented a post-processing technique based on wavelet transform filtering of the image which allows us to strongly enhance the presence of point-like sources in regions where the primary halo dominates. We detect for the first time the BD binary HD130948BC in the optical band I with a SNR~9 at 2.561"\pm 0.007" (46.5 AU) from HD130948A and confirm in two independent dataset that the object is real,as opposed to time-varying residual speckles.We do not resolve the binary, which can be explained by astrometric results posterior to our observations that predict a separation below the NOT resolution.We reach at this distance a contrast of dI = 11.30 \pm 0.11, and estimate a combined magnitude for this binary to I = 16.49 \pm 0.11 and a I-J colour 3.29 \pm 0.13. At 1", we reach a detectability 10.5 mag fainter than the primary after image post-processing. We obtain on-sky validation of a technique based on speckle imaging and wavelet-transform processing,which improves the high contrast capabilities of speckle imaging.The I-J colour measured for the BD companion is slightly bluer, but still consistent with what typically found for L2 dwarfs(~3.4-3.6)., Comment: accepted in A\&A

In this paper, we present an original observational approach, which combines, for the first time, traditional speckle imaging with image post-processing to obtain in the optical domain diffraction-limited images with high contrast (1e-5) within 0.5 to 2 arcseconds around a bright star. The post-processing step is based on wavelet filtering an has analogy with edge enhancement and high-pass filtering. Our I-band on-sky results with the 2.5-m Nordic Telescope (NOT) and the lucky imaging instrument FASTCAM show that we are able to detect L-type brown dwarf companions around a solar-type star with a contrast DI~12 at 2" and with no use of any coronographic capability, which greatly simplifies the instrumental and hardware approach. This object has been detected from the ground in J and H bands so far only with AO-assisted 8-10 m class telescopes (Gemini, Keck), although more recently detected with small-class telescopes in the K band. Discussing the advantage and disadvantage of the optical regime for the detection of faint intrinsic fluxes close to bright stars, we develop some perspectives for other fields, including the study of dense cores in globular clusters. To the best of our knowledge this is the first time that high contrast considerations are included in optical speckle imaging approach., Comment: Proceedings of SPIE conference - Ground-based and Airborne Instrumentation for Astronomy III (Conference 7735), San Diego 2010

We estimate the fraction of mass that is composed of compact objects in gravitational lens galaxies. This study is based on microlensing measurements (obtained from the literature) of a sample of 29 quasar image pairs seen through 20 lens galaxies. We determine the baseline for no microlensing magnification between two images from the ratios of emission line fluxes. Relative to this baseline, the ratio between the continua of the two images gives the difference in microlensing magnification. The histogram of observed microlensing events peaks close to no magnification and is concentrated below 0.6 magnitudes, although two events of high magnification, $\Delta m \sim 1.5$, are also present. We study the likelihood of the microlensing measurements using frequency distributions obtained from simulated microlensing magnification maps for different values of the fraction of mass in compact objects, $\alpha$. The concentration of microlensing measurements close to $\Delta m \sim 0$ can be explained only by simulations corresponding to very low values of $\alpha$ (10% or less). A maximum likelihood test yields $\alpha=0.05_{-0.03}^{+0.09}$ (90% confidence interval) for a quasar continuum source of intrinsic size $r_{s_0}\sim 2.6 \cdot 10^{15} \rm cm$. Regarding the current controversy about Milky Way/LMC and M31 microlensing studies, our work supports the hypothesis of a very low content in MACHOS (Massive Compact Halo Objects).

We present integral field spectroscopic observations of the quadruple-lensed QSO SDSS 1004+4112 taken with the fiber system INTEGRAL at the William Herschel Telescope on 2004 January 19. In May 2003 a blueward enhancement in the high ionization lines of SDSS 1004+4112A was detected and then faded. Our observations are the first to note a second event of similar characteristics less than one year after. Although initially attributed to microlensing, the resemblance among the spectra of both events and the absence of microlensing-induced changes in the continuum of component A are puzzling. The lack of a convincing explanation under the microlensing or intrinsic variability hypotheses makes the observed enhancements particularly relevant, calling for close monitoring of this object., Comment: 4 pages, 5 figures