466 results on '"Osborne, Timothy F"'
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2. β-Adrenergic Signal and Epigenomic Regulatory Process for Adaptive Thermogenesis
3. Enhanced SREBP2-driven cholesterol biosynthesis by PKCλ/ι deficiency in intestinal epithelial cells promotes aggressive serrated tumorigenesis
4. Mitochondrial biogenesis in white adipose tissue mediated by JMJD1A-PGC-1 axis limits age-related metabolic disease
5. SREBP signaling is essential for effective B cell responses
6. Cholesterol biosynthesis supports the growth of hepatocarcinoma lesions depleted of fatty acid synthase in mice and humans
7. SCAP deficiency facilitates obesity and insulin resistance through shifting adipose tissue macrophage polarization
8. Therapeutic strategy targeting host lipolysis limits infection by SARS-CoV-2 and influenza A virus
9. MYPT1-PP1β phosphatase negatively regulates both chromatin landscape and co-activator recruitment for beige adipogenesis
10. Distinct subpopulations of human subcutaneous adipose tissue precursor cells revealed by single-cell RNA sequencing
11. Dipyridamole Inhibits Lipogenic Gene Expression by Retaining SCAP-SREBP in the Endoplasmic Reticulum
12. SREBP-2-deficient and hypomorphic mice reveal roles for SREBP-2 in embryonic development and SREBP-1c expression.
13. An Atlas of Promoter Chromatin Modifications and HiChIP Regulatory Interactions in Human Subcutaneous Adipose-Derived Stem Cells
14. Carbon dioxide regulates cholesterol levels through SREBP2
15. SREBP-1a–stimulated lipid synthesis is required for macrophage phagocytosis downstream of TLR4-directed mTORC1
16. Spatiotemporal dynamics of SETD5-containing NCoR–HDAC3 complex determines enhancer activation for adipogenesis
17. Isocitrate dehydrogenase 2 protects mice from high-fat diet-induced metabolic stress by limiting oxidative damage to the mitochondria from brown adipose tissue
18. Lipid balance must be just right to prevent development of severe liver damage
19. Partitioning Circadian Transcription by SIRT6 Leads to Segregated Control of Cellular Metabolism
20. T1R2 receptor-mediated glucose sensing in the upper intestine potentiates glucose absorption through activation of local regulatory pathways
21. Skeletal muscle overexpression of nicotinamide phosphoribosyl transferase in mice coupled with voluntary exercise augments exercise endurance
22. Sterol regulatory element–binding proteins are essential for the metabolic programming of effector T cells and adaptive immunity
23. Genome-wide analysis of hepatic LRH-1 reveals a promoter binding preference and suggests a role in regulating genes of lipid metabolism in concert with FXR
24. Integrated Expression Profiling and Genome-Wide Analysis of ChREBP Targets Reveals the Dual Role for ChREBP in Glucose-Regulated Gene Expression
25. Genome-wide interrogation of hepatic FXR reveals an asymmetric IR-1 motif and synergy with LRH-1
26. Transcriptional Control of Subcutaneous Adipose Tissue by the Transcription Factor CTCF Modulates Heterogeneity in Fat Distribution in Women.
27. An Atlas of Promoter Chromatin Modifications and HiChIP Regulatory Interactions in Human Subcutaneous Adipose-Derived Stem Cells.
28. Two uniquely arranged thyroid hormone response elements in the far upstream 5' flanking region confer direct thyroid hormone regulation to the murine cholesterol 7alpha hydroxylase gene
29. Nutrient Regulation of Gene Expression by the Sterol Regulatory Element Binding Proteins: Increased Recruitment of Gene-Specific Coregulatory Factors and Selective Hyperacetylation of Histone H3 in vivo
30. Specificity in Cholesterol Regulation of Gene Expression by Coevolution of Sterol Regulatory DNA Element and Its Binding Protein
31. Sterol Regulation of Acetyl Coenzyme A Carboxylase: A Mechanism for Coordinate Control of Cellular Lipid
32. SETDB2 Links Glucocorticoid to Lipid Metabolism through Insig2a Regulation
33. Mitochondrial Biogenesis in White Adipose Tissue Mediated by JMJD1A-PGC-1 Axis Limits Age-Related Metabolic Disease
34. Differential open chromatin profile and transcriptomic signature define depot-specific human subcutaneous preadipocytes: primary outcomes
35. SREBP signaling is essential for effective B cell responses
36. Correction: Isocitrate dehydrogenase 2 protects mice from high-fat diet-induced metabolic stress by limiting oxidative damage to the mitochondria from brown adipose tissue
37. Unique role for lncRNA HOTAIR in defining depot-specific gene expression patterns in human adipose-derived stem cells
38. An SREBP-Responsive microRNA Operon Contributes to a Regulatory Loop for Intracellular Lipid Homeostasis
39. SREBPs: metabolic integrators in physiology and metabolism
40. Transcriptional and DNA Methylation Signatures of Subcutaneous Adipose Tissue and Adipose-Derived Stem Cells in PCOS Women
41. A feed-forward loop amplifies nutritional regulation of PNPLA3
42. Genome-Wide Analysis of SREBP-1 Binding in Mouse Liver Chromatin Reveals a Preference for Promoter Proximal Binding to a New Motif
43. COUP-TFII Acts Downstream of Wnt/β-Catenin Signal to Silence PPARγ Gene Expression and Repress Adipogenesis
44. Genome-wide Localization of SREBP-2 in Hepatic Chromatin Predicts a Role in Autophagy
45. Linking Lipid Metabolism to the Innate Immune Response in Macrophages through Sterol Regulatory Element Binding Protein-1a
46. SREBP-1c impairs ULK1 sulfhydration-mediated autophagic flux to promote hepatic steatosis in high-fat-diet-fed mice
47. Domains of Transcription Factor Sp1 Required for Synergistic Activation with Sterol Regulatory Element Binding Protein 1 of Low Density Lipoprotein Receptor Promoter
48. Multiple Genes Encode Nuclear Factor 1-Like Proteins that Bind to the Promoter for 3-hydroxy-3-methylglutaryl-coenzyme A Reductase
49. Mapping a Eukaryotic Promoter: A DNA Sequence Required for in vivo Expression of Adenovirus Pre-Early Functions
50. DNA Methylation as a Marker of Body Shape in Premenopausal Women
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