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4. Supplementary Figure 1 from Salt-Inducible Kinase 2 Regulates Mitotic Progression and Transcription in Prostate Cancer

Author

Bon, Hélène, primary, Wadhwa, Karan, primary, Schreiner, Alexander, primary, Osborne, Michelle, primary, Carroll, Thomas, primary, Ramos-Montoya, Antonio, primary, Ross-Adams, Helen, primary, Visser, Matthieu, primary, Hoffmann, Ralf, primary, Ahmed, Ahmed Ashour, primary, Neal, David E., primary, and Mills, Ian G., primary

Published
2023
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5. Supplementary Table S1 from Salt-Inducible Kinase 2 Regulates Mitotic Progression and Transcription in Prostate Cancer

Author

Bon, Hélène, primary, Wadhwa, Karan, primary, Schreiner, Alexander, primary, Osborne, Michelle, primary, Carroll, Thomas, primary, Ramos-Montoya, Antonio, primary, Ross-Adams, Helen, primary, Visser, Matthieu, primary, Hoffmann, Ralf, primary, Ahmed, Ahmed Ashour, primary, Neal, David E., primary, and Mills, Ian G., primary

Published
2023
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6. Supplementary Figure 8 from Salt-Inducible Kinase 2 Regulates Mitotic Progression and Transcription in Prostate Cancer

Author

Bon, Hélène, primary, Wadhwa, Karan, primary, Schreiner, Alexander, primary, Osborne, Michelle, primary, Carroll, Thomas, primary, Ramos-Montoya, Antonio, primary, Ross-Adams, Helen, primary, Visser, Matthieu, primary, Hoffmann, Ralf, primary, Ahmed, Ahmed Ashour, primary, Neal, David E., primary, and Mills, Ian G., primary

Published
2023
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7. Supplementary Figure Legend from Salt-Inducible Kinase 2 Regulates Mitotic Progression and Transcription in Prostate Cancer

Author

Bon, Hélène, primary, Wadhwa, Karan, primary, Schreiner, Alexander, primary, Osborne, Michelle, primary, Carroll, Thomas, primary, Ramos-Montoya, Antonio, primary, Ross-Adams, Helen, primary, Visser, Matthieu, primary, Hoffmann, Ralf, primary, Ahmed, Ahmed Ashour, primary, Neal, David E., primary, and Mills, Ian G., primary

Published
2023
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8. Supplementary Figure 3 from Salt-Inducible Kinase 2 Regulates Mitotic Progression and Transcription in Prostate Cancer

Author

Bon, Hélène, primary, Wadhwa, Karan, primary, Schreiner, Alexander, primary, Osborne, Michelle, primary, Carroll, Thomas, primary, Ramos-Montoya, Antonio, primary, Ross-Adams, Helen, primary, Visser, Matthieu, primary, Hoffmann, Ralf, primary, Ahmed, Ahmed Ashour, primary, Neal, David E., primary, and Mills, Ian G., primary

Published
2023
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9. Supplementary Figure 5 from Salt-Inducible Kinase 2 Regulates Mitotic Progression and Transcription in Prostate Cancer

Author

Bon, Hélène, primary, Wadhwa, Karan, primary, Schreiner, Alexander, primary, Osborne, Michelle, primary, Carroll, Thomas, primary, Ramos-Montoya, Antonio, primary, Ross-Adams, Helen, primary, Visser, Matthieu, primary, Hoffmann, Ralf, primary, Ahmed, Ahmed Ashour, primary, Neal, David E., primary, and Mills, Ian G., primary

Published
2023
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10. Supplementary Figure 4 from Salt-Inducible Kinase 2 Regulates Mitotic Progression and Transcription in Prostate Cancer

Author

Bon, Hélène, primary, Wadhwa, Karan, primary, Schreiner, Alexander, primary, Osborne, Michelle, primary, Carroll, Thomas, primary, Ramos-Montoya, Antonio, primary, Ross-Adams, Helen, primary, Visser, Matthieu, primary, Hoffmann, Ralf, primary, Ahmed, Ahmed Ashour, primary, Neal, David E., primary, and Mills, Ian G., primary

Published
2023
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11. Supplementary Figure 6 from Salt-Inducible Kinase 2 Regulates Mitotic Progression and Transcription in Prostate Cancer

Author

Bon, Hélène, primary, Wadhwa, Karan, primary, Schreiner, Alexander, primary, Osborne, Michelle, primary, Carroll, Thomas, primary, Ramos-Montoya, Antonio, primary, Ross-Adams, Helen, primary, Visser, Matthieu, primary, Hoffmann, Ralf, primary, Ahmed, Ahmed Ashour, primary, Neal, David E., primary, and Mills, Ian G., primary

Published
2023
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12. Supplementary Figure 7 from Salt-Inducible Kinase 2 Regulates Mitotic Progression and Transcription in Prostate Cancer

Author

Bon, Hélène, primary, Wadhwa, Karan, primary, Schreiner, Alexander, primary, Osborne, Michelle, primary, Carroll, Thomas, primary, Ramos-Montoya, Antonio, primary, Ross-Adams, Helen, primary, Visser, Matthieu, primary, Hoffmann, Ralf, primary, Ahmed, Ahmed Ashour, primary, Neal, David E., primary, and Mills, Ian G., primary

Published
2023
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13. Supplementary Figure 2 from Salt-Inducible Kinase 2 Regulates Mitotic Progression and Transcription in Prostate Cancer

Author

Bon, Hélène, primary, Wadhwa, Karan, primary, Schreiner, Alexander, primary, Osborne, Michelle, primary, Carroll, Thomas, primary, Ramos-Montoya, Antonio, primary, Ross-Adams, Helen, primary, Visser, Matthieu, primary, Hoffmann, Ralf, primary, Ahmed, Ahmed Ashour, primary, Neal, David E., primary, and Mills, Ian G., primary

Published
2023
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14. Additional file 1 of The cost of reducing starting RNA quantity for Illumina BeadArrays: A bead-level dilution experiment

Author

Lynch, Andy G, Hadfield, James, Dunning, Mark J, Osborne, Michelle, Thorne, Natalie P, and Tavaré, Simon

Abstract

Additional file 1: Supplementary material. File giving details of 1) Experimental Design: Array Layout, 2) Lab Methods: Obtaining bead-level data, 3) Lab Methods: Quality assessment metrics, 4) Lab Methods: Quality assessment - comparison with MAQC, 5) Lab Methods: Quality assessment - Association between starting RNA quantity and intensity, 6) Criteria for including bead-types, 7) Results: Detection, 8) Results: Negative controls, 9) Results: Differential expression but no expression, and 10) Results: Differential expression - detection of small changes. (PDF 475 KB)

Published
2021
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16. The androgen receptor fuels prostate cancer by regulating central metabolism and biosynthesis

Author

Massie, Charles E, Lynch, Andy, Ramos‐Montoya, Antonio, Boren, Joan, Stark, Rory, Fazli, Ladan, Warren, Anne, Scott, Helen, Madhu, Basetti, Sharma, Naomi, Bon, Helene, Zecchini, Vinny, Smith, Donna‐Michelle, DeNicola, Gina M, Mathews, Nik, Osborne, Michelle, Hadfield, James, MacArthur, Stewart, Adryan, Boris, Lyons, Scott K, Brindle, Kevin M, Griffiths, John, Gleave, Martin E, Rennie, Paul S, Neal, David E, and Mills, Ian G

Published
2011
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17. The genomic and transcriptomic architecture of 2,000 breast tumours reveals novel subgroups

Author

Curtis, Christina, Shah, Sohrab P., Chin, Suet-Feung, Turashvili, Gulisa, Rueda, Oscar M., Dunning, Mark J., Speed, Doug, Lynch, Andy G., Samarajiwa, Shamith, Yuan, Yinyin, Gräf, Stefan, Ha, Gavin, Haffari, Gholamreza, Bashashati, Ali, Russell, Roslin, McKinney, Steven, Aparicio, Samuel, Brenton, James D., Ellis, Ian, Huntsman, David, Pinder, Sarah, Purushotham, Arnie, Murphy, Leigh, Caldas, Carlos, Bardwell, Helen, Ding, Zhihao, Jones, Linda, Liu, Bin, Papatheodorou, Irene, Sammut, Stephen J., Wishart, Gordon, Chia, Steven, Gelmon, Karen, Speers, Caroline, Watson, Peter, Blamey, Roger, Green, Andrew, Macmillan, Douglas, Rakha, Emad, Gillett, Cheryl, Grigoriadis, Anita, de Rinaldis, Emanuele, Tutt, Andy, Parisien, Michelle, Troup, Sandra, Chan, Derek, Fielding, Claire, Maia, Ana-Teresa, McGuire, Sarah, Osborne, Michelle, Sayalero, Sara M., Spiteri, Inmaculada, Hadfield, James, Bell, Lynda, Chow, Katie, Gale, Nadia, Kovalik, Maria, Ng, Ying, Prentice, Leah, Tavaré, Simon, Markowetz, Florian, Langerød, Anita, Provenzano, Elena, and Børresen-Dale, Anne-Lise

Published
2012
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20. Independence of HIF1a and androgen signaling pathways in prostate cancer

Author

Tran, Maxine GB, primary, Bibby, Becky AS, additional, Yang, Lingjian, additional, Lo, Franklin, additional, Warren, Anne, additional, Shukla, Deepa, additional, Osborne, Michelle, additional, Hadfield, James, additional, Carroll, Thomas, additional, Stark, Rory, additional, Scott, Helen, additional, Ramos-Montoya, Antonio, additional, Massie, Charlie, additional, Maxwell, Patrick, additional, West, Catharine ML, additional, Mills, Ian G., additional, and Neal, David E., additional

Published
2019
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21. The cost of reducing starting RNA quantity for Illumina BeadArrays: A bead-level dilution experiment

Author

Osborne Michelle, Dunning Mark J, Hadfield James, Lynch Andy G, Thorne Natalie P, and Tavaré Simon

Subjects
Biotechnology, TP248.13-248.65, Genetics, QH426-470
Abstract

Abstract Background The demands of microarray expression technologies for quantities of RNA place a limit on the questions they can address. As a consequence, the RNA requirements have reduced over time as technologies have improved. In this paper we investigate the costs of reducing the starting quantity of RNA for the Illumina BeadArray platform. This we do via a dilution data set generated from two reference RNA sources that have become the standard for investigations into microarray and sequencing technologies. Results We find that the starting quantity of RNA has an effect on observed intensities despite the fact that the quantity of cRNA being hybridized remains constant. We see a loss of sensitivity when using lower quantities of RNA, but no great rise in the false positive rate. Even with 10 ng of starting RNA, the positive results are reliable although many differentially expressed genes are missed. We see that there is some scope for combining data from samples that have contributed differing quantities of RNA, but note also that sample sizes should increase to compensate for the loss of signal-to-noise when using low quantities of starting RNA. Conclusions The BeadArray platform maintains a low false discovery rate even when small amounts of starting RNA are used. In contrast, the sensitivity of the platform drops off noticeably over the same range. Thus, those conducting experiments should not opt for low quantities of starting RNA without consideration of the costs of doing so. The implications for experimental design, and the integration of data from different starting quantities, are complex.

Published
2010
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22. Salt-Inducible Kinase 2 Regulates Mitotic Progression and Transcription in Prostate Cancer

Author

Bon, Hélène, primary, Wadhwa, Karan, additional, Schreiner, Alexander, additional, Osborne, Michelle, additional, Carroll, Thomas, additional, Ramos-Montoya, Antonio, additional, Ross-Adams, Helen, additional, Visser, Matthieu, additional, Hoffmann, Ralf, additional, Ahmed, Ahmed Ashour, additional, Neal, David E., additional, and Mills, Ian G., additional

Published
2015
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23. Food Follies: Food Safety for College Students

Author

Osborne, Michelle and Osborne, Michelle

Abstract

This project involves the production and dissemination of a basic food storage and safety course geared toward college students. The course covers basic preparation, sanitation, proper cooking temperatures, chilling and storage, as well as common pathogens to be aware of.

Published
2010

24. Food Follies: Food Safety for College Students

Author

Food Science and Technology, Williams, Robert, Williams, Robert C., Boyer, Renee R., Eifert, Joseph D., Osborne, Michelle, Food Science and Technology, Williams, Robert, Williams, Robert C., Boyer, Renee R., Eifert, Joseph D., and Osborne, Michelle

Abstract

This project involves the production and dissemination of a basic food storage and safety course geared toward college students. The course covers basic preparation, sanitation, proper cooking temperatures, chilling and storage, as well as common pathogens to be aware of.

Published
2010

25. Abstract 1714: Transcriptional networks downstream of the AR identify clinically relevant prostate cancer targets

Author

Massie, Charlie, primary, Lynch, Andy, additional, Stark, Rory, additional, Ramos-Montoya, Anthony, additional, Fazli, Ladan, additional, Warren, Anne, additional, Scott, Helen, additional, Bon, Helene, additional, Sharma, Naomi, additional, Zecchini, Vinny, additional, Matthews, Nik, additional, Osborne, Michelle, additional, Hadfield, James, additional, Swatton, Jane, additional, McArthur, Stewart, additional, Adryan, Boris, additional, Grigorenko, Elena, additional, Watt, Carolyn, additional, McEwan, Iain, additional, Rennie, Paul, additional, Neal, David, additional, and Mills, Ian G., additional

Published
2010
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35. Corporate Social Responsibility: Sexual Exploitation of Children in the Costa Rican Hotel Tourist Industry

Author

Flynn Osborne, Michelle

Subjects
child labor, child sexual exploitation, corporate social responsibility, Costa Rica, human trafficking, Business, Business Administration, Management, and Operations, Business Law, Public Responsibility, and Ethics
Abstract

According to the 2016 International Labour Organization (ILO), more than 168 million children are forced to labor worldwide, and more than half of these children work in some of the worst forms. Sexual exploitation and human trafficking are classified by the ILO as being some of the worst forms of child labor existing in the twenty-first century. Child labor in the worst forms are more prevalent in developing countries due to poverty and lack of education. The United States Department of State monitors human trafficking and child sexual exploitation through an annual Trafficking in Persons Report (TIP). The 2015 TIP report verified that Costa Rica has been downgraded to the Tier 2 Watch List. If by 2016 the TIP report recommendations are not implemented for the prevention of human trafficking and child labor, the country will fall to a Tier 3 List and face possible sanctions from the US and the World Bank. Since the government has failed to implement necessary reforms, Costa Rica is in a dilemma. The tourist industry is a prime source of income for the country while at the same time the hotel industry is a prime source of where child sexual exploitation occurs (Hetter, 2012). Thus, there was a need for research to discover what is the hotel industry’s corporate social responsibility towards the children who are sexually exploited in the Costa Rican hotels.

Published
2016

36. EXPLORATION OF THE RELATIONSHIP BETWEEN PAIN INTENSITY, COMFORT LEVEL AND PATIENT SATISFACTION AMONG ORTHOPEDIC PATIENTS FOLLOWING KNEE SURGERY ON POSTOPERATIVE DAY ONE

Author

Osborne, Michelle

Subjects
Nursing, Health Care, Teaching, pain,pain management, postoperative, surgery,total knee replacement, comfort,comfort intervention, non-pharmacological intervention, healing, comfort theory, and patient satisfaction
Abstract

ABSTRACTPain is a common phenomenon after surgery. Specifically, postoperative pain after total knee arthroplasty remains one of the most important challenges facing patients undergoing this surgery. Pain and comfort management continue to be overlooked and inadequately managed (McCaffery, Herr & Pasero, 2011; Pasero et al., 2009). Despite the availability of numerous effective analgesics and new drug administration technologies, research studies continue to show suboptimal pain management (ASPAN, 2013). A major focus of postoperative nursing care for patients following total joint replacement surgery is pain management. Although education of today’s nurse will require some emphasis on technological advances, fundamental caring practices cannot be neglected. Interventions focusing on the comfort needs of patients and families are entirely within the realm of nursing practice, and are proposed to be strongly related to quality of care and patient satisfaction (Kolcaba, 2012). The purpose of this research study was to examine the relationship between pain intensity, comfort level and patient satisfaction of orthopedic patients following knee surgery on postoperative day one (the first day after surgery). The comfort theory was used as the theoretical foundation for this study. This study was conducted as descriptive/correlational study in which the relationship among variables (postoperative pain, comfort and patient satisfaction) was examined. A convenience sample of 40 male and female adult patients admitted to the hospital for elective total knee replacement /arthroplasty surgery beginning October 2014. The 0-10 Numerical Rating Scale (NRS-11) was used to measure pain intensity. The Perianesthesia Comfort Questionnaire was used to measure comfort. Data collection to assess patient satisfaction was based on questions from the Hospital Consumer Assessment of Healthcare Providers and Systems (HCAHPS) Survey and Press Ganey Survey. The results of this study did not reveal statistically significant relationships among patient satisfaction, comfort, and pain intensity. Perhaps this finding is due to the high patient satisfaction scores. Nurses play a key role in the management of pain for patients having knee replacement surgery. They are the primary group of health care professionals responsible for the ongoing assessment, monitoring of patients and initiating interventions that help assure patients’ pain are appropriately managed. To adequately study this phenomenon, replication of the study across different hospital systems using a large sample size with more variability in satisfaction are needed.

Published
2015

37. OSBORNE ILLUSION: SANTA CAME TO TOWN.

Author

Osborne, Paul and Osborne, Michelle

Abstract

The article discusses the magic trick which involves the magic appearance of Santa Claus which was developed by Paul Osborne. It notes that the magician utilizes the sneak-on principle which accomplishes the magic trick. It also mentions that spectators see a typical front door at center stage with holiday packages on either side in which Santa Claus is hidden in one of the packages.

Published
2010

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