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2. Cover

Author

Osborn, Michael

Published
2018

5. Index

Author

Osborn, Michael

Published
2018

19. Preface

Author

Osborn, Michael

Published
2018

22. Clinical and biological landscape of constitutional mismatch-repair deficiency syndrome: an International Replication Repair Deficiency Consortium cohort study

Author

Ercan, Ayse Bahar, Aronson, Melyssa, Fernandez, Nicholas R, Chang, Yuan, Levine, Adrian, Liu, Zhihui Amy, Negm, Logine, Edwards, Melissa, Bianchi, Vanessa, Stengs, Lucie, Chung, Jiil, Al-Battashi, Abeer, Reschke, Agnes, Lion, Alex, Ahmad, Alia, Lassaletta, Alvaro, Reddy, Alyssa T, Al-Darraji, Amir F, Shah, Amish C, Van Damme, An, Bendel, Anne, Rashid, Aqeela, Margol, Ashley S, Kelly, Bethany L, Pencheva, Bojana, Heald, Brandie, Lemieux-Anglin, Brianna, Crooks, Bruce, Koschmann, Carl, Gilpin, Catherine, Porter, Christopher C, Gass, David, Samuel, David, Ziegler, David S, Blumenthal, Deborah T, Kuo, Dennis John, Hamideh, Dima, Basel, Donald, Khuong-Quang, Dong-Anh, Stearns, Duncan, Opocher, Enrico, Carceller, Fernando, Baris Feldman, Hagit, Toledano, Helen, Winer, Ira, Scheers, Isabelle, Fedorakova, Ivana, Su, Jack M, Vengoechea, Jaime, Sterba, Jaroslav, Knipstein, Jeffrey, Hansford, Jordan R, Gonzales-Santos, Julieta Rita, Bhatia, Kanika, Bielamowicz, Kevin J, Minhas, Khurram, Nichols, Kim E, Cole, Kristina A, Penney, Lynette, Hjort, Magnus Aasved, Sabel, Magnus, Gil-da-Costa, Maria Joao, Murray, Matthew J, Miller, Matthew, Blundell, Maude L, Massimino, Maura, Al-Hussaini, Maysa, Al-Jadiry, Mazin F, Comito, Melanie A, Osborn, Michael, Link, Michael P, Zapotocky, Michal, Ghalibafian, Mithra, Shaheen, Najma, Mushtaq, Naureen, Waespe, Nicolas, Hijiya, Nobuko, Fuentes-Bolanos, Noemi, Ahmad, Olfat, Chamdine, Omar, Roy, Paromita, Pichurin, Pavel N, Nyman, Per, Pearlman, Rachel, Auer, Rebecca C, Sukumaran, Reghu K, Kebudi, Rejin, Dvir, Rina, Raphael, Robert, Elhasid, Ronit, McGee, Rose B, Chami, Rose, Noss, Ryan, Tanaka, Ryuma, Raskin, Salmo, Sen, Santanu, Lindhorst, Scott, Perreault, Sebastien, Caspi, Shani, Riaz, Shazia, Constantini, Shlomi, Albert, Sophie, Chaleff, Stanley, Bielack, Stefan, Chiaravalli, Stefano, Cramer, Stuart Louis, Roy, Sumita, Cahn, Suzanne, Penna, Suzanne, Hamid, Syed Ahmer, Ghafoor, Tariq, Imam, Uzma, Larouche, Valerie, Magimairajan Issai, Vanan, Foulkes, William D, Lee, Yi Yen, Nathan, Paul C, Maruvka, Yosef E, Greer, Mary-Louise C, Durno, Carol, Shlien, Adam, Ertl-Wagner, Birgit, Villani, Anita, Malkin, David, Hawkins, Cynthia, Bouffet, Eric, Das, Anirban, and Tabori, Uri

Published
2024
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23. Genomic predictors of response to PD-1 inhibition in children with germline DNA replication repair deficiency

Author

Das, Anirban, Sudhaman, Sumedha, Morgenstern, Daniel, Coblentz, Ailish, Chung, Jiil, Stone, Simone C, Alsafwani, Noor, Liu, Zhihui Amy, Karsaneh, Ola Abu Al, Soleimani, Shirin, Ladany, Hagay, Chen, David, Zatzman, Matthew, Cabric, Vanja, Nobre, Liana, Bianchi, Vanessa, Edwards, Melissa, Sambira Nahum, Lauren C, Ercan, Ayse B, Nabbi, Arash, Constantini, Shlomi, Dvir, Rina, Yalon-Oren, Michal, Campino, Gadi Abebe, Caspi, Shani, Larouche, Valerie, Reddy, Alyssa, Osborn, Michael, Mason, Gary, Lindhorst, Scott, Bronsema, Annika, Magimairajan, Vanan, Opocher, Enrico, De Mola, Rebecca Loret, Sabel, Magnus, Frojd, Charlotta, Sumerauer, David, Samuel, David, Cole, Kristina, Chiaravalli, Stefano, Massimino, Maura, Tomboc, Patrick, Ziegler, David S, George, Ben, Van Damme, An, Hijiya, Nobuko, Gass, David, McGee, Rose B, Mordechai, Oz, Bowers, Daniel C, Laetsch, Theodore W, Lossos, Alexander, Blumenthal, Deborah T, Sarosiek, Tomasz, Yen, Lee Yi, Knipstein, Jeffrey, Bendel, Anne, Hoffman, Lindsey M, Luna-Fineman, Sandra, Zimmermann, Stefanie, Scheers, Isabelle, Nichols, Kim E, Zapotocky, Michal, Hansford, Jordan R, Maris, John M, Dirks, Peter, Taylor, Michael D, Kulkarni, Abhaya V, Shroff, Manohar, Tsang, Derek S, Villani, Anita, Xu, Wei, Aronson, Melyssa, Durno, Carol, Shlien, Adam, Malkin, David, Getz, Gad, Maruvka, Yosef E, Ohashi, Pamela S, Hawkins, Cynthia, Pugh, Trevor J, Bouffet, Eric, and Tabori, Uri

Subjects
Rare Diseases, Pediatric, Cancer, Neurosciences, Pediatric Cancer, Genetics, 2.1 Biological and endogenous factors, Aetiology, Adolescent, Adult, B7-H1 Antigen, Biomarkers, Tumor, Child, DNA Repair, DNA Replication, Female, Germ-Line Mutation, Humans, Immune Checkpoint Inhibitors, Male, Neoplasms, Prospective Studies, Retrospective Studies, Survival Analysis, Tumor Microenvironment, Young Adult, Medical and Health Sciences, Immunology
Abstract

Cancers arising from germline DNA mismatch repair deficiency or polymerase proofreading deficiency (MMRD and PPD) in children harbour the highest mutational and microsatellite insertion-deletion (MS-indel) burden in humans. MMRD and PPD cancers are commonly lethal due to the inherent resistance to chemo-irradiation. Although immune checkpoint inhibitors (ICIs) have failed to benefit children in previous studies, we hypothesized that hypermutation caused by MMRD and PPD will improve outcomes following ICI treatment in these patients. Using an international consortium registry study, we report on the ICI treatment of 45 progressive or recurrent tumors from 38 patients. Durable objective responses were observed in most patients, culminating in a 3 year survival of 41.4%. High mutation burden predicted response for ultra-hypermutant cancers (>100 mutations per Mb) enriched for combined MMRD + PPD, while MS-indels predicted response in MMRD tumors with lower mutation burden (10-100 mutations per Mb). Furthermore, both mechanisms were associated with increased immune infiltration even in 'immunologically cold' tumors such as gliomas, contributing to the favorable response. Pseudo-progression (flare) was common and was associated with immune activation in the tumor microenvironment and systemically. Furthermore, patients with flare who continued ICI treatment achieved durable responses. This study demonstrates improved survival for patients with tumors not previously known to respond to ICI treatment, including central nervous system and synchronous cancers, and identifies the dual roles of mutation burden and MS-indels in predicting sustained response to immunotherapy.

Published
2022

25. Late effects in survivors of infant acute lymphoblastic leukaemia—a study of the Australian and New Zealand Children’s Haematology/Oncology Group

Author

Mironova, Denitza, Saraswati, Chitra M., Downie, Peter, Lai, Chow Yee, Cook, Eleanor, Carruthers, Vickyanne, Moukhaiber, Perla, Molloy, Fiona, Serov, Joshua, McKinnon, Elizabeth, Alvaro, Frank, Osborn, Michael, Revesz, Tamas, Prestidge, Tim, Cross, Siobhan, Bateman, Caroline M., Moore, Andrew S., Khaw, Seong Lin, Mateos, Marion K., and Kotecha, Rishi S.

Published
2023
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26. Survival Benefit for Individuals With Constitutional Mismatch Repair Deficiency Undergoing Surveillance

Author

Durno, Carol, Ercan, Ayse Bahar, Bianchi, Vanessa, Edwards, Melissa, Aronson, Melyssa, Galati, Melissa, Atenafu, Eshetu G, Abebe-Campino, Gadi, Al-Battashi, Abeer, Alharbi, Musa, Azad, Vahid Fallah, Baris, Hagit N, Basel, Donald, Bedgood, Raymond, Bendel, Anne, Ben-Shachar, Shay, Blumenthal, Deborah T, Blundell, Maude, Bornhorst, Miriam, Bronsema, Annika, Cairney, Elizabeth, Rhode, Sara, Caspi, Shani, Chamdin, Aghiad, Chiaravalli, Stefano, Constantini, Shlomi, Crooks, Bruce, Das, Anirban, Dvir, Rina, Farah, Roula, Foulkes, William D, Frenkel, Zehavit, Gallinger, Bailey, Gardner, Sharon, Gass, David, Ghalibafian, Mithra, Gilpin, Catherine, Goldberg, Yael, Goudie, Catherine, Hamid, Syed Ahmer, Hampel, Heather, Hansford, Jordan R, Harlos, Craig, Hijiya, Nobuko, Hsu, Saunders, Kamihara, Junne, Kebudi, Rejin, Knipstein, Jeffrey, Koschmann, Carl, Kratz, Christian, Larouche, Valerie, Lassaletta, Alvaro, Lindhorst, Scott, Ling, Simon C, Link, Michael P, De Mola, Rebecca Loret, Luiten, Rebecca, Lurye, Michal, Maciaszek, Jamie L, MagimairajanIssai, Vanan, Maher, Ossama M, Massimino, Maura, McGee, Rose B, Mushtaq, Naureen, Mason, Gary, Newmark, Monica, Nicholas, Garth, Nichols, Kim E, Nicolaides, Theodore, Opocher, Enrico, Osborn, Michael, Oshrine, Benjamin, Pearlman, Rachel, Pettee, Daniel, Rapp, Jan, Rashid, Mohsin, Reddy, Alyssa, Reichman, Lara, Remke, Marc, Robbins, Gabriel, Roy, Sumita, Sabel, Magnus, Samuel, David, Scheers, Isabelle, Schneider, Kami Wolfe, Sen, Santanu, Stearns, Duncan, Sumerauer, David, Swallow, Carol, Taylor, Leslie, Thomas, Gregory, Toledano, Helen, Tomboc, Patrick, Van Damme, An, Winer, Ira, Yalon, Michal, Yen, Lee Yi, Zapotocky, Michal, Zelcer, Shayna, and Ziegler, David S

Subjects
Cancer, Brain Disorders, Clinical Research, Digestive Diseases, Prevention, Brain Cancer, Rare Diseases, Adolescent, Adult, Brain Neoplasms, Child, Child, Preschool, Colorectal Neoplasms, DNA Mismatch Repair, DNA Repair Enzymes, Early Detection of Cancer, Female, Follow-Up Studies, Humans, Male, Neoplastic Syndromes, Hereditary, Population Surveillance, Prognosis, Prospective Studies, Survival Rate, United States, Young Adult, Clinical Sciences, Oncology and Carcinogenesis, Oncology & Carcinogenesis
Abstract

PurposeConstitutional mismatch repair deficiency syndrome (CMMRD) is a lethal cancer predisposition syndrome characterized by early-onset synchronous and metachronous multiorgan tumors. We designed a surveillance protocol for early tumor detection in these individuals.Patients and methodsData were collected from patients with confirmed CMMRD who were registered in the International Replication Repair Deficiency Consortium. Tumor spectrum, efficacy of the surveillance protocol, and malignant transformation of low-grade lesions were examined for the entire cohort. Survival outcomes were analyzed for patients followed prospectively from the time of surveillance implementation.ResultsA total of 193 malignant tumors in 110 patients were identified. Median age of first cancer diagnosis was 9.2 years (range: 1.7-39.5 years). For patients undergoing surveillance, all GI and other solid tumors, and 75% of brain cancers were detected asymptomatically. By contrast, only 16% of hematologic malignancies were detected asymptomatically (P < .001). Eighty-nine patients were followed prospectively and used for survival analysis. Five-year overall survival (OS) was 90% (95% CI, 78.6 to 100) and 50% (95% CI, 39.2 to 63.7) when cancer was detected asymptomatically and symptomatically, respectively (P = .001). Patient outcome measured by adherence to the surveillance protocol revealed 4-year OS of 79% (95% CI, 54.8 to 90.9) for patients undergoing full surveillance, 55% (95% CI, 28.5 to 74.5) for partial surveillance, and 15% (95% CI, 5.2 to 28.8) for those not under surveillance (P < .0001). Of the 64 low-grade tumors detected, the cumulative likelihood of transformation from low-to high-grade was 81% for GI cancers within 8 years and 100% for gliomas in 6 years.ConclusionSurveillance and early cancer detection are associated with improved OS for individuals with CMMRD.

Published
2021

27. Management of children and adolescents with chronic myeloid leukemia in blast phase: International pediatric CML expert panel recommendations

Author

Sembill, Stephanie, Ampatzidou, Maria, Chaudhury, Sonali, Dworzak, Michael, Kalwak, Krzysztof, Karow, Axel, Kiani, Alexander, Krumbholz, Manuela, Luesink, Maaike, Naumann-Bartsch, Nora, De Moerloose, Barbara, Osborn, Michael, Schultz, Kirk R., Sedlacek, Petr, Giona, Fiorina, Zwaan, Christian Michel, Shimada, Hiroyuki, Versluijs, Birgitta, Millot, Frederic, Hijiya, Nobuko, Suttorp, Meinolf, and Metzler, Markus

Published
2023
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29. Novel modes of MPL activation in triple-negative myeloproliferative neoplasms

Author

Samaraweera, Saumya E., Geukens, Tatjana, Casolari, Debora A., Nguyen, Tran, Sun, Caitlyn, Bailey, Sheree, Moore, Sarah, Feng, Jinghua, Schreiber, Andreas W., Parker, Wendy T., Brown, Anna L., Butcher, Carolyn, Bardy, Peter G., Osborn, Michael, Scott, Hamish S., Talaulikar, Dipti, Grove, Carolyn S., Hahn, Christopher N., D'Andrea, Richard J., and Ross, David M.

Published
2023
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30. COVID-19–Associated cardiac pathology at the postmortem evaluation: a collaborative systematic review

Author

Almamlouk, Raghed, Kashour, Tarek, Obeidat, Sawsan, Bois, Melanie C., Maleszewski, Joseph J., Omrani, Osama A., Tleyjeh, Rana, Berbari, Elie, Chakhachiro, Zaher, Zein-Sabatto, Bassel, Gerberi, Dana, Tleyjeh, Imad M., Paniz Mondolfi, Alberto E., Finn, Aloke V., Duarte-Neto, Amaro Nunes, Rapkiewicz, Amy V., Frustaci, Andrea, Keresztesi, Arthur-Atilla, Hanley, Brian, Märkl, Bruno, Lardi, Christelle, Bryce, Clare, Lindner, Diana, Aguiar, Diego, Westermann, Dirk, Stroberg, Edana, Duval, Eric J., Youd, Esther, Bulfamante, Gaetano Pietro, Salmon, Isabelle, Auer, Johann, Hirschbühl, Klaus, Absil, Lara, Barton, Lisa M., Ferraz da Silva, Luiz Fernando, Moore, Luiza, Dolhnikoff, Marisa, Lammens, Martin, Osborn, Michael, Remmelink, Myriam, Nascimento Saldiva, Paulo Hilario, Jorens, Philippe G., Craver, Randall, Aparecida de Almeida Monteiro, Renata, Scendoni, Roberto, Mukhopadhyay, Sanjay, Suzuki, Tadaki, Mauad, Thais, Fracasso, Tony, and Grimes, Zachary

Published
2022
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32. Prospective longitudinal evaluation of treatment-related toxicity and health-related quality of life during the first year of treatment for pediatric acute lymphoblastic leukemia

Author

Schilstra, Clarissa E., McCleary, Karen, Fardell, Joanna E., Donoghoe, Mark W., McCormack, Emma, Kotecha, Rishi S., Lourenco, Richard De Abreu, Ramachandran, Shanti, Cockcroft, Ruelleyn, Conyers, Rachel, Cross, Siobhan, Dalla-Pozza, Luciano, Downie, Peter, Revesz, Tamas, Osborn, Michael, Alvaro, Frank, Wakefield, Claire E., Marshall, Glenn M., Mateos, Marion K., and Trahair, Toby N.

Published
2022
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33. An MRD-stratified pediatric protocol is as deliverable in adolescents and young adults as in children with ALL

Author

Greenwood, Matthew, Trahair, Toby, Sutton, Rosemary, Osborn, Michael, Kwan, John, Mapp, Sally, Howman, Rebecca, Anazodo, Antoinette, Wylie, Brenton, D'Rozario, James, Hertzberg, Mark, Irving, Ian, Yeung, David, Coyle, Luke, Jager, Amanda, Engeler, Dan, Venn, Nicola, Frampton, Chris, Wei, Andrew H., Bradstock, Kenneth, and Dalla-Pozza, Luciano

Published
2021
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35. Comprehensive Analysis of Hypermutation in Human Cancer

Author

Campbell, Brittany B, Light, Nicholas, Fabrizio, David, Zatzman, Matthew, Fuligni, Fabio, de Borja, Richard, Davidson, Scott, Edwards, Melissa, Elvin, Julia A, Hodel, Karl P, Zahurancik, Walter J, Suo, Zucai, Lipman, Tatiana, Wimmer, Katharina, Kratz, Christian P, Bowers, Daniel C, Laetsch, Theodore W, Dunn, Gavin P, Johanns, Tanner M, Grimmer, Matthew R, Smirnov, Ivan V, Larouche, Valérie, Samuel, David, Bronsema, Annika, Osborn, Michael, Stearns, Duncan, Raman, Pichai, Cole, Kristina A, Storm, Phillip B, Yalon, Michal, Opocher, Enrico, Mason, Gary, Thomas, Gregory A, Sabel, Magnus, George, Ben, Ziegler, David S, Lindhorst, Scott, Issai, Vanan Magimairajan, Constantini, Shlomi, Toledano, Helen, Elhasid, Ronit, Farah, Roula, Dvir, Rina, Dirks, Peter, Huang, Annie, Galati, Melissa A, Chung, Jiil, Ramaswamy, Vijay, Irwin, Meredith S, Aronson, Melyssa, Durno, Carol, Taylor, Michael D, Rechavi, Gideon, Maris, John M, Bouffet, Eric, Hawkins, Cynthia, Costello, Joseph F, Meyn, M Stephen, Pursell, Zachary F, Malkin, David, Tabori, Uri, and Shlien, Adam

Subjects
Biological Sciences, Biomedical and Clinical Sciences, Genetics, Oncology and Carcinogenesis, Human Genome, Cancer, Rare Diseases, Cancer Genomics, 2.1 Biological and endogenous factors, Good Health and Well Being, Adult, Child, Cluster Analysis, DNA Polymerase II, DNA Polymerase III, DNA Replication, Humans, Mutation, Neoplasms, Poly-ADP-Ribose Binding Proteins, DNA repair, DNA replication, cancer genomics, cancer predisposition, hypermutation, immune checkpoint inhibitors, mismatch repair, mutator, Medical and Health Sciences, Developmental Biology, Biological sciences, Biomedical and clinical sciences
Abstract

We present an extensive assessment of mutation burden through sequencing analysis of >81,000 tumors from pediatric and adult patients, including tumors with hypermutation caused by chemotherapy, carcinogens, or germline alterations. Hypermutation was detected in tumor types not previously associated with high mutation burden. Replication repair deficiency was a major contributing factor. We uncovered new driver mutations in the replication-repair-associated DNA polymerases and a distinct impact of microsatellite instability and replication repair deficiency on the scale of mutation load. Unbiased clustering, based on mutational context, revealed clinically relevant subgroups regardless of the tumors' tissue of origin, highlighting similarities in evolutionary dynamics leading to hypermutation. Mutagens, such as UV light, were implicated in unexpected cancers, including sarcomas and lung tumors. The order of mutational signatures identified previous treatment and germline replication repair deficiency, which improved management of patients and families. These data will inform tumor classification, genetic testing, and clinical trial design.

Published
2017

36. The furin cleavage site in the SARS-CoV-2 spike protein is required for transmission in ferrets

Author

Peacock, Thomas P., Goldhill, Daniel H., Zhou, Jie, Baillon, Laury, Frise, Rebecca, Swann, Olivia C., Kugathasan, Ruthiran, Penn, Rebecca, Brown, Jonathan C., Sanchez-David, Raul Y., Braga, Luca, Williamson, Maia Kavanagh, Hassard, Jack A., Staller, Ecco, Hanley, Brian, Osborn, Michael, Giacca, Mauro, Davidson, Andrew D., Matthews, David A., and Barclay, Wendy S.

Published
2021
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37. Supplementary Figures S1-S5 from Combined Immunotherapy Improves Outcome for Replication-Repair-Deficient (RRD) High-Grade Glioma Failing Anti–PD-1 Monotherapy: A Report from the International RRD Consortium

Author

Das, Anirban, primary, Fernandez, Nicholas R., primary, Levine, Adrian, primary, Bianchi, Vanessa, primary, Stengs, Lucie K., primary, Chung, Jiil, primary, Negm, Logine, primary, Dimayacyac, Jose Rafael, primary, Chang, Yuan, primary, Nobre, Liana, primary, Ercan, Ayse B., primary, Sanchez-Ramirez, Santiago, primary, Sudhaman, Sumedha, primary, Edwards, Melissa, primary, Larouche, Valerie, primary, Samuel, David, primary, Van Damme, An, primary, Gass, David, primary, Ziegler, David S., primary, Bielack, Stefan S., primary, Koschmann, Carl, primary, Zelcer, Shayna, primary, Yalon-Oren, Michal, primary, Campino, Gadi Abede, primary, Sarosiek, Tomasz, primary, Nichols, Kim E., primary, Loret De Mola, Rebecca, primary, Bielamowicz, Kevin, primary, Sabel, Magnus, primary, Frojd, Charlotta A., primary, Wood, Matthew D., primary, Glover, Jason M., primary, Lee, Yi-Yen, primary, Vanan, Magimairajan, primary, Adamski, Jenny K., primary, Perreault, Sebastien, primary, Chamdine, Omar, primary, Hjort, Magnus Aasved, primary, Zapotocky, Michal, primary, Carceller, Fernando, primary, Wright, Erin, primary, Fedorakova, Ivana, primary, Lossos, Alexander, primary, Tanaka, Ryuma, primary, Osborn, Michael, primary, Blumenthal, Deborah T., primary, Aronson, Melyssa, primary, Bartels, Ute, primary, Huang, Annie, primary, Ramaswamy, Vijay, primary, Malkin, David, primary, Shlien, Adam, primary, Villani, Anita, primary, Dirks, Peter B., primary, Pugh, Trevor J., primary, Getz, Gad, primary, Maruvka, Yosef E., primary, Tsang, Derek S., primary, Ertl-Wagner, Birgit, primary, Hawkins, Cynthia, primary, Bouffet, Eric, primary, Morgenstern, Daniel A., primary, and Tabori, Uri, primary

Published
2024
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38. Combined Immunotherapy Improves Outcome for Replication-Repair-Deficient (RRD) High-Grade Glioma Failing Anti–PD-1 Monotherapy: A Report from the International RRD Consortium

Author

Das, Anirban, primary, Fernandez, Nicholas R., additional, Levine, Adrian, additional, Bianchi, Vanessa, additional, Stengs, Lucie K., additional, Chung, Jiil, additional, Negm, Logine, additional, Dimayacyac, Jose Rafael, additional, Chang, Yuan, additional, Nobre, Liana, additional, Ercan, Ayse B., additional, Sanchez-Ramirez, Santiago, additional, Sudhaman, Sumedha, additional, Edwards, Melissa, additional, Larouche, Valerie, additional, Samuel, David, additional, Van Damme, An, additional, Gass, David, additional, Ziegler, David S., additional, Bielack, Stefan S., additional, Koschmann, Carl, additional, Zelcer, Shayna, additional, Yalon-Oren, Michal, additional, Campino, Gadi Abede, additional, Sarosiek, Tomasz, additional, Nichols, Kim E., additional, Loret De Mola, Rebecca, additional, Bielamowicz, Kevin, additional, Sabel, Magnus, additional, Frojd, Charlotta A., additional, Wood, Matthew D., additional, Glover, Jason M., additional, Lee, Yi-Yen, additional, Vanan, Magimairajan, additional, Adamski, Jenny K., additional, Perreault, Sebastien, additional, Chamdine, Omar, additional, Hjort, Magnus Aasved, additional, Zapotocky, Michal, additional, Carceller, Fernando, additional, Wright, Erin, additional, Fedorakova, Ivana, additional, Lossos, Alexander, additional, Tanaka, Ryuma, additional, Osborn, Michael, additional, Blumenthal, Deborah T., additional, Aronson, Melyssa, additional, Bartels, Ute, additional, Huang, Annie, additional, Ramaswamy, Vijay, additional, Malkin, David, additional, Shlien, Adam, additional, Villani, Anita, additional, Dirks, Peter B., additional, Pugh, Trevor J., additional, Getz, Gad, additional, Maruvka, Yosef E., additional, Tsang, Derek S., additional, Ertl-Wagner, Birgit, additional, Hawkins, Cynthia, additional, Bouffet, Eric, additional, Morgenstern, Daniel A., additional, and Tabori, Uri, additional

Published
2024
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41. Head and Neck Cancer: United Kingdom National Multidisciplinary Guidelines, Sixth Edition.

Author

Homer, Jarrod J, Winter, Stuart C, Paleri, Vinidh, Smith, Maria, Bisase, Brian, Vassiliou, Leandros, Ragbir, Maniram, Sood, Sanjai, Ashley, Martin, Gadhok, Kamini, Broll, Judith, Osborn, Michael, and Halliday, Katharine

Subjects
HEAD & neck cancer treatment, MEDICAL protocols, SERIAL publications, PUBLIC health surveillance, PHYSICAL therapy, CANCER relapse, DISEASE management, CANCER patient medical care, EXERCISE therapy, HEAD & neck cancer, HEALTH care teams, NUTRITION
Abstract

An editorial is presented on broad range of UK professionals involved in the care of patients with head and neck cancer. Topics include underpinning the basis of care of patients with head and neck cancer, which apply across the spectrum of management; and guidelines can be also used as an educational resource for clinicians, and for insight into head and neck cancer care for non-clinicians.

Published
2024
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43. Access and Models of Care

Author

Ferrari, Andrea, Albritton, Karen, Osborn, Michael, Barr, Ronald, Johnson, Rebecca H., Stark, Dan, Whelan, Jeremy, Reaman, Gregory H., Series editor, Smith, Franklin O., Series editor, Bleyer, Archie, editor, Barr, Ronald, editor, Ries, Lynn, editor, Whelan, Jeremy, editor, and Ferrari, Andrea, editor

Published
2017
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44. The Enduring Heart of the Public Speaking Course.

Author

Osborn, Michael

Abstract

The public speaking course has been around for a long time but, while there have been changes, the heart of the course remains intact. The many skills and sensitivities instructors try to cultivate in their students come together in three fundamental metaphors that may reflect deep tendencies in what is taught. In the first metaphor, student as builder, central to organizing ideas into a cohesive pattern are the arts of designing and building speeches, of learning the nature and range of supporting materials and what they can best support, and the strategies of outlining. A second metaphor involves the student as weaver, practicing the art of weaving symbols into the fabric of a speech and evidence and proof into the tapestry of powerful arguments. The third metaphor of student as climber expresses vividly a transformational approach to the public speaking class, with students--both speakers and listeners--growing and developing rapidly, expanding their horizons, when the course works successfully. The kind of personal growth experience the three metaphors encourage and guide is profoundly humanizing, and, as such, can serve as an antidote to the consumer metaphor in undergraduate education. (Contains 25 references.) (CR)

Published
1996

47. The personal experience of chronic benign low back pain : an interpretative phenomenological analysis

Author

Osborn, Michael

Subjects
616, Medicine
Abstract

This thesis is a qualitative study of chronic benign low back pain (CBLBP). Psychological factors play an important role in the genesis and maintenance of CBLBP but the processes involved are poorly understood. The meaning of the pain for the sufferer is considered to be important and more research into this area that takes an idiographic approach is recommended in the literature. Three empirical studies are reported which employ Interpretative Phenomenological Analysis (IPA) to explore the personal experience of CBLBP. A range of themes are discussed that capture the meaning of the pain for the sufferer and help to understand the dynamic relationship between the pain sensation, distress and disability. The first study is exploratory, the participants' struggle to make a coherent sense of their pain is revealed along with the related personal and social implications. In the second study the experience of pain itself is focused on more closely in the context of a simple intervention. Descriptions of the pain are given which reveal its threatening aspect and suggest that the participants' self-appraisal in the face of this threat is important. The factors underlying change are discussed and the contribution of contextual factors is emphasised. The first two studies indicated that the self-concept was worthy of further study and it became the explicit focus of the third study. The relevance of the self was highlighted and it was shown to be indivisible from the lived experience of CBLBP. The three studies reveal the multi-dimensional complexity of CBLBP and highlight how its inherent `unpleasantnessr'e presentsm ore than a noxious sensory experience but unfolds within a dynamic personal and social context. The emergent themes are reviewed and discussed in relation to the literature and implications for further research and clinical practice are suggested.

Published
2002

48. Beyond Medical Care: How Different National Models of Care Impact the Experience of Adolescent and Young Adult Cancer Patients

Author

Patterson, Pandora, primary, Jacobsen, Rebecca L., additional, McDonald, Fiona E.J., additional, Pflugeisen, Chaya M., additional, Bibby, Kit, additional, Macpherson, Catherine Fiona, additional, Thompson, Kate, additional, Murnane, Andrew, additional, Anazodo, Antoinette, additional, Sansom-Daly, Ursula M., additional, Osborn, Michael P., additional, Hayward, Allan, additional, Kok, Cindy, additional, and Johnson, Rebecca H., additional

Published
2023
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50. Australian and New Zealand consensus guideline for paediatric newly diagnosed immune thrombocytopaenia endorsed by Australian New Zealand Children's Haematology and Oncology Group

Author

Verissimo, Vanessa, primary, Carter, Tina, additional, Wright, Helen, additional, Robertson, Jeremy, additional, Osborn, Michael, additional, Bradbeer, Peter, additional, Sabesan, Vanaja, additional, Saxon, Ben, additional, Barbaro, Pasquale, additional, Crighton, Gemma, additional, Chamberlain, Janis, additional, Zheng, Silvia, additional, and Freeman, Kate, additional

Published
2023
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