1. A Study of the Impact of Cannabis on Doses of Discharge Antipsychotic Medication in Individuals with Schizophrenia or Schizoaffective Disorder
- Author
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Ruchir Arvind Patel, Titilayo Makanjuola, Osarhiemen Ruth Aimienwanu, Satyajit Mohite, Rania Elkhatib, Olaoluwa O. Okusaga, Jigar Chotalia, Sumana Goddu, Taiwo Babatope, Devanshu Patel, and Joel Shah
- Subjects
Adult ,Hospitals, Psychiatric ,Male ,medicine.medical_specialty ,Marijuana Abuse ,Exacerbation ,medicine.medical_treatment ,Schizoaffective disorder ,Marijuana Smoking ,Comorbidity ,03 medical and health sciences ,Young Adult ,0302 clinical medicine ,Internal medicine ,medicine ,Humans ,Young adult ,Antipsychotic ,Chlorpromazine ,Psychiatry ,biology ,Middle Aged ,biology.organism_classification ,medicine.disease ,Patient Discharge ,United States ,030227 psychiatry ,Psychiatry and Mental health ,Psychotic Disorders ,Schizophrenia ,Linear Models ,Female ,Schizophrenic Psychology ,Cannabis ,Psychology ,030217 neurology & neurosurgery ,medicine.drug ,Antipsychotic Agents - Abstract
Patients with schizophrenia or schizoaffective disorder have a high prevalence of comorbid cannabis use disorder (CUD). CUD has been associated with poorer outcomes in patients. We compared doses of antipsychotic medications at the time of discharge from hospital among inpatients with schizophrenia or schizoaffective disorder with or without concurrent cannabis use. We reviewed the medical records of patients (N = 8157) with schizophrenia or schizoaffective disorder discharged from the hospital between 2008 and 2012. The patients were divided into two groups; those with urine drug tests positive for cannabis and those negative for cannabis. Doses of antipsychotic medications were converted to chlorpromazine equivalents. Bivariate analyses were done with Student's t test for continuous variables and χ 2 test for categorical variables. Linear regression was carried out to adjust for potential confounders. Unadjusted analysis revealed that the cannabis positive group was discharged on lower doses of antipsychotic medication compared with the cannabis negative group (geometric mean chlorpromazine equivalent doses 431.22 ± 2.20 vs 485.18 ± 2.21; P
- Published
- 2016