5 results on '"Osa-Ruiz E"'
Search Results
2. Cerebral Microbleeds in Advanced Dementia: Clinical and Pathological Correlates.
- Author
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Boyano I, Ramos A, López-Alvarez J, Mendoza-Rebolledo C, Osa-Ruiz E, Rodríguez I, Pérez A, Alfayate E, González B, Fernández L, Agüera-Ortiz L, Rábano A, and Olazarán J
- Subjects
- Aged, 80 and over, Alzheimer Disease complications, Brain diagnostic imaging, Cerebral Amyloid Angiopathy, Cerebral Hemorrhage etiology, Dementia complications, Female, Humans, Longitudinal Studies, Male, Severity of Illness Index, Cerebral Hemorrhage diagnostic imaging, Dementia diagnostic imaging, Magnetic Resonance Imaging
- Abstract
Objective: We conducted a longitudinal study to explore the clinical and pathological correlates of cerebral microbleeds (CMBs) in institutionalized patients with dementia., Methods: Clinical and magnetic resonance imaging (MRI) data were extracted from 182 nursing home patients (mean age [standard deviation]: 81.3 [6.9], 78.0% female, and 83.4% moderate to severe dementia), which were divided according to the CMBs number and location. One-year follow-up data were obtained from 153 patients, and postmortem pathological diagnosis was available in 40 patients., Results: Cerebral microbleeds were observed in 42.9% of patients and were associated with MRI ischemic lesions ( P < .0005). In the adjusted analysis, lobar CMB predicted worsening of parkinsonism (standardized β: 0.43) and gait (standardized β: 0.24). A pathological diagnosis of Alzheimer's disease was less frequent in the brains of patients with lobar and deep CMB (33.3% vs 85.3%; P < .05)., Conclusion: Cerebral microbleeds were linked to cerebrovascular disease and predicted motor deterioration in institutionalized people with advanced dementia.
- Published
- 2018
- Full Text
- View/download PDF
3. Social robots in advanced dementia.
- Author
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Valentí Soler M, Agüera-Ortiz L, Olazarán Rodríguez J, Mendoza Rebolledo C, Pérez Muñoz A, Rodríguez Pérez I, Osa Ruiz E, Barrios Sánchez A, Herrero Cano V, Carrasco Chillón L, Felipe Ruiz S, López Alvarez J, León Salas B, Cañas Plaza JM, Martín Rico F, Abella Dago G, and Martínez Martín P
- Abstract
Aims: Pilot studies applying a humanoid robot (NAO), a pet robot (PARO) and a real animal (DOG) in therapy sessions of patients with dementia in a nursing home and a day care center., Methods: In the nursing home, patients were assigned by living units, based on dementia severity, to one of the three parallel therapeutic arms to compare: CONTROL, PARO and NAO (Phase 1) and CONTROL, PARO, and DOG (Phase 2). In the day care center, all patients received therapy with NAO (Phase 1) and PARO (Phase 2). Therapy sessions were held 2 days per week during 3 months. Evaluation, at baseline and follow-up, was carried out by blind raters using: the Global Deterioration Scale (GDS), the Severe Mini Mental State Examination (sMMSE), the Mini Mental State Examination (MMSE), the Neuropsychiatric Inventory (NPI), the Apathy Scale for Institutionalized Patients with Dementia Nursing Home version (APADEM-NH), the Apathy Inventory (AI) and the Quality of Life Scale (QUALID). Statistical analysis included descriptive statistics and non-parametric tests performed by a blinded investigator., Results: In the nursing home, 101 patients (Phase 1) and 110 patients (Phase 2) were included. There were no significant differences at baseline. The relevant changes at follow-up were: (Phase 1) patients in the robot groups showed an improvement in apathy; patients in NAO group showed a decline in cognition as measured by the MMSE scores, but not the sMMSE; the robot groups showed no significant changes between them; (Phase 2) QUALID scores increased in the PARO group. In the day care center, 20 patients (Phase 1) and 17 patients (Phase 2) were included. The main findings were: (Phase 1) improvement in the NPI irritability and the NPI total score; (Phase 2) no differences were observed at follow-up.
- Published
- 2015
- Full Text
- View/download PDF
4. Motor effects of radio electric asymmetric conveyer in Alzheimer's disease: results from a cross-over trial.
- Author
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Olazarán J, González B, Osa-Ruiz E, Felipe-Ruiz S, Boyano I, Fontani V, Castagna A, Mendoza C, Zea MA, Frades B, Rinaldi S, and Martínez-Martín P
- Subjects
- Aged, 80 and over, Alzheimer Disease physiopathology, Brain physiopathology, Cross-Over Studies, Day Care, Medical, Double-Blind Method, Electric Stimulation Therapy adverse effects, Female, Humans, Male, Nursing Homes, Radio Waves adverse effects, Treatment Outcome, Alzheimer Disease therapy, Electric Stimulation Therapy methods, Motor Activity, Radiofrequency Therapy
- Abstract
We conducted a randomized, cross-over trial to investigate the feasibility, safety, and motor effects of brain stimulation with radio electric asymmetric conveyer (REAC) technique in patients with Alzheimer's disease (AD). Neuropostural optimization (NPO) and sham protocol were administered to 60 patients from the nursing home and day care units of the Alzheimer Center Reina Sofía Foundation. The mean age was 84.1 (SD 7.9) years and 86.7% of the subjects were female. Motor measures were collected at baseline (T1), immediately (T2), seven (T3), and 11 days (T4) after treatment and, following cross-over, immediately (T5), seven (T6), and 11 (T7) days after treatment. Close safety surveillance was conducted from seven days before T1 to the end of the study (T7), with total study duration of 35 days. Wilcoxon test was utilized in the efficacy analysis, considering T1 and T5 as independent baseline assessments and using a threshold of p < 0.05 (corrected) for statistical significance. The NPO protocol was easily administered and well accepted by the participants. Axial movements improved at T3 and T4 after NPO and at T2 after sham NPO, but no significant effects were observed in axial movements in the second phase of the trial. The effects of NPO in gait performance were not consistent. There were six falls between T2 and T7, but only two of them occurred in patients who had received NPO. In light of safety and feasibility of REAC, a trial with the more intense neuropsycho-physical optimization protocol is warranted.
- Published
- 2014
- Full Text
- View/download PDF
5. Motor effects of REAC in advanced Alzheimer's disease: results from a pilot trial.
- Author
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Olazarán J, González B, López-Álvarez J, Castagna A, Osa-Ruiz E, Herrero-Cano V, Agüera-Ortiz L, Rinaldi S, and Martínez-Martín P
- Subjects
- Activities of Daily Living, Aged, 80 and over, Female, Follow-Up Studies, Humans, Male, Neuropsychological Tests, Pilot Projects, Psychiatric Status Rating Scales, Statistics, Nonparametric, Alzheimer Disease complications, Alzheimer Disease therapy, Deep Brain Stimulation methods, Movement Disorders etiology
- Abstract
We conducted a pilot, randomized, controlled trial to mainly investigate the feasibility, safety, and short-term motor effects of brain stimulation with radio electric asymmetric conveyer (REAC) technology in patients with advanced Alzheimer's disease (AD) who also experience some gait dysfunction. Neuropostural optimization (NPO) or sham protocol was administered to 31 nursing home patients (mean [SD] age 84.7 [7.0], 77.4% female, 6.5% moderate dementia, 51.6% moderately severe dementia, and 41.9% severe dementia). Motor, cognitive, functional, and behavioral measures were conducted at baseline (T1), immediately after treatment (T2), and 1-3 weeks after treatment (T3). There was transitory dysfunction in axial movements at T2 in the experimental group with no other differences between the experimental group and the control group in the planned analyses. However, after reanalysis of data based on outcome, improvement in capacity of walking was observed at T3 in the experimental group (p < 0.05). NPO administration was comfortable and safe. These results warrant further research with NPO and other REAC protocols to improve motor deterioration in AD.
- Published
- 2013
- Full Text
- View/download PDF
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