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Current research in High Energy Cosmic Ray Physics touches on fundamental questions regarding the origin of cosmic rays, their composition, the acceleration mechanisms, and their production. Unambiguous measurements of the energy spectra and of the composition of cosmic rays at the "knee" region could provide some of the answers to the above questions. So far only ground based observations, which rely on sophisticated models describing high energy interactions in the Earth's atmosphere, have been possible due to the extremely low particle rates at these energies. A calorimetry based space experiment that could provide not only flux measurements but also energy spectra and particle identification, would certainly overcome some of the uncertainties of ground based experiments. Given the expected particle fluxes, a very large acceptance is needed to collect a sufficient quantity of data, in a time compatible with the duration of a space mission. This in turn, contrasts with the lightness and compactness requirements for space based experiments. We present a novel idea in calorimetry which addresses these issues whilst limiting the mass and volume of the detector. In this paper we report on a four year R&D program where we investigated materials, coatings, photo-sensors, Front End electronics, and mechanical structures with the aim of designing a high performance, high granularity calorimeter with the largest possible acceptance. Details are given of the design choices, component characterisation, and of the construction of a sizeable prototype (Calocube) which has been used in various tests with particle beams.

In order to extend the direct observation of high-energy cosmic rays up to the PeV region, highly performing calorimeters with large geometrical acceptance and high energy resolution are required. Within the constraint of the total mass of the apparatus, crucial for a space mission, the calorimeters must be optimized with respect to their geometrical acceptance, granularity and absorption depth. CaloCube is a homogeneous calorimeter with cubic geometry, to maximise the acceptance being sensitive to particles from every direction in space; granularity is obtained by relying on small cubic scintillating crystals as active elements. Different scintillating materials have been studied. The crystal sizes and spacing among them have been optimized with respect to the energy resolution. A prototype, based on CsI(Tl) cubic crystals, has been constructed and tested with particle beams. Some results of tests with different beams at CERN are presented., Comment: Seven pages, seven pictures. Proceedings of INSTR17 Novosibirsk

Recent years have seen an “explosion" in the abilities of scientists to use neuroscience in new domains. Unfortunately, it is little known and reported on how advertising companies make more effective pharmaceutical drugs commercials. The purpose of this paper is to analyze how neuromarketing techniques may impact the consumer response to pharmaceutical advertising campaigns. The result shows that using neuromarketing methods a pharmaceutical company can better understand the conscious and unconscious consumer’s thoughts and tailor specific marketing messages.

A new multielement X-ray fluorescence detector is presented, specifically designed to probe the chemical speciation of trace 3d elements down to the p.p.m. range., X-ray absorption fine-structure (XAFS) spectroscopy can assess the chemical speciation of the elements providing their coordination and oxidation state, information generally hidden to other techniques. In the case of trace elements, achieving a good quality XAFS signal poses several challenges, as it requires high photon flux, counting statistics and detector linearity. Here, a new multi-element X-ray fluorescence detector is presented, specifically designed to probe the chemical speciation of trace 3d elements down to the p.p.m. range. The potentialities of the detector are presented through a case study: the speciation of ultra-diluted elements (Fe, Mn and Cr) in geological rocks from a calcareous formation related to the dispersal processes from Ontong (Java) volcanism (mid-Cretaceous). Trace-elements speciation is crucial in evaluating the impact of geogenic and anthropogenic harmful metals on the environment, and to evaluate the risks to human health and ecosystems. These results show that the new detector is suitable for collecting spectra of 3d elements in trace amounts in a calcareous matrix. The data quality is high enough that quantitative data analysis could be performed to determine their chemical speciation.

The direct observation of high-energy cosmic rays, up to the PeV energy region, will increasingly rely on highly performing calorimeters, and the physics performance will be primarily determined by their geometrical acceptance and energy resolution. Thus, it is extremely important to optimize their geometrical design, granularity and absorption depth, with respect to the totalmass of the apparatus, which is amongst the most important constraints for a space mission. CaloCube is an homogeneous calorimeter whose basic geometry is cubic and isotropic, obtained by filling the cubic volume with small cubic scintillating crystals. In this way it is possible to detect particles arriving from every direction in space, thus maximizing the acceptance. This design summarizes a three-year R&D activity, aiming to both optimize and study the full-scale performance of the calorimeter, in the perspective of a cosmic-ray space mission, and investigate a viable technical design by means of the construction of several sizable prototypes. A large scale prototype, made of a mesh of 5x5x18 CsI(Tl) crystals, has been constructed and tested on high-energy particle beams at CERN SPS accelerator. In this paper we describe the CaloCube design and present the results relative to the response of the large scale prototype to electrons., 24 pages, 19 figures

Given the good performances in terms of geometrical acceptance and energy resolution, calorimeters are the best suited detectors to measure high energy cosmic rays directly in space. However, in order to exploit this potential, the design of calorimeters must be carefully optimized to take into account all limitations related to space missions, due mainly to the mass of the experimental apparatus. CaloCube is a three years R&D project, approved and financed by INFN in 2014, aiming to optimize the design of a space-borne calorimeter by the use of a cubic, homogeneous and isotropic geometry. In order to maximize detector performances with respect to the total mass of the apparatus, comparative studies on different scintillating materials, different sizes of crystals and different spacings among them have been performed making use of Monte Carlo simulations. In parallel to this activity, several prototypes instrumented with CsI:Tl cubic crystals have been constructed and tested with particle beams (muons, electrons, protons and ions). Both simulations and prototypes showed that the CaloCube design leads to a good particle energy resolution (< 2% for electromagnetic showers, < 40% for hadronic showers) and a good effective geometric factor (> 3:5 m2 sr for electromagnetic showers, > 2:5 m2 sr for hadronic showers). Thanks to these performances, in 5 years of operation it would be possible to measure the ux of electrons+positrons up to some tens of TeV and the uxes of protons and nuclei up to some units of PeV/nucleon, hence extending these measurements by at least one order of magnitude in energy compared to the experiments currently operating in space.

Precise measurements of the energy spectra and of the composition of cosmic rays in the PeV region could improve our knowledge regarding their origin, acceleration mechanism, propagation, and composition. At the present time, spectral measurements in this region are mainly derived from data collected by ground-based detectors, because of the very low particle rates at these energies. Unfortunately, these results are affected by the high uncertainties typical of indirect measurements, which depend on the complicated modeling of the interaction of the primary particle with the atmosphere. A space experiment dedicated to measurements in this energy region has to achieve a balance between the requirements of lightness and compactness, with that of a large acceptance to cope with the low particle rates. CaloCube is a four-year-old R&amp, D project, approved and financed by the Istituto Nazionale di Fisica Nucleare (INFN) in 2014, aiming to optimize the design of a space-borne calorimeter. The large acceptance needed is obtained by maximizing the number of entrance windows, while thanks to its homogeneity and high segmentation this new detector achieves an excellent energy resolution and an enhanced separation power between hadrons and electrons. In order to optimize detector performances with respect to the total mass of the apparatus, comparative studies on different scintillating materials, different sizes of crystals, and different spacings among them have been performed making use of MonteCarlo simulations. In parallel to simulations studies, several prototypes instrumented with CsI(Tl) (Caesium Iodide, Tallium doped) cubic crystals have been constructed and tested with particle beams. Moreover, the last development of CaloCube, the Tracker-In-Calorimeter (TIC) project, financed by the INFN in 2018, is focused on the feasibility of including several silicon layers at different depths in the calorimeter in order to reconstruct the particle direction. In fact, an important requirement for &gamma, ray astronomy is to have a good angular resolution in order to allow precise identification of astrophysical sources in space. In respect to the traditional approach of using a tracker with passive material in front of the calorimeter, the TIC solution can save a significant amount of mass budget in a space satellite experiment, which can then be exploited to improve the acceptance and the resolution of the calorimeter. In this paper, the status of the project and perspectives for future developments are presented.

The direct observation of high-energy cosmic rays, up to the PeV region, will increasingly rely on highly performing calorimeters, and the physics performance will be primarily determined by their geometrical acceptance and energy resolution. Thus, it is extremely important to optimize their geometrical design, granularity, and absorption depth, with respect to the total mass of the apparatus, which is among the most important constraints for a space mission. Calocube is a homogeneous calorimeter whose basic geometry is cubic and isotropic, so as to detect particles arriving from every direction in space, thus maximizing the acceptance; granularity is obtained by filling the cubic volume with small cubic scintillating crystals. This design forms the basis of a three-year R & D activity which has been approved and financed by INFN. A comparative study of different scintillating materials has been performed. Optimal values for the size of the crystals and spacing among them have been studied. Different geometries, besides the cubic one, and the possibility to implement dual-readout techniques have been investigated. A prototype, instrumented with CsI(Tl) cubic crystals, has been constructed and tested with particle beams. An overview of the obtained results will be presented and the perspectives for future space experiments will be discussed.

CaloCube is an R&D project borne to develop a novel calorimeter design, optimized for high-energy cosmic ray measurements in space. A small prototype made of CsI(Tl) elements has been built and tested on particle beams. A final version, made of 5×5×18 crystals and with dual readout (two photodiodes for each crystal), to cover the full required dynamic range, is under construction and will be tested at CERN SPS in Summer 2016. The dual readout compensation technique were developed and the feasibility to extract ÄŒ erenkov signals from CsI crystals verified.

The direct measurement of the cosmic-ray spectrum, up to the knee region, is one of the instrumental challenges for next generation space experiments. The main issue for these measurements is a steeply falling spectrum with increasing energy, so the physics performance of the space calorimeters are primarily determined by their geometrical acceptance and energy resolution. CaloCube is a three-year R&D; project, approved and financed by INFN in 2014, aiming to optimize the design of a space-born calorimeter. The peculiarity of the design of CaloCube is its capability of detecting particles coming from any direction, and not only those on its upper surface. To ensure that the quality of the measurement does not depend on the arrival direction of the particles, the calorimeter will be designed as homogeneous and isotropic as possible. In addition, to achieve a high discrimination power for hadrons and nuclei with respect to electrons, the sensitive elements of the calorimeter need to have a fine 3-D sampling capability. In order to optimize the detector performances with respect to the total mass of the apparatus, which is the most important constraint for a space launch, a comparative study of different scintillating materials has been performed using detailed Monte Carlo simulation based on the FLUKA package. In parallel to simulation studies, a prototype consisting in 14 layers of 3 x 3 CsI(Tl) crystals per layer has been assembled and tested with particle beams. An overview of the obtained results during the first two years of the project will be presented and the future of the detector will be discussed too.

The paper reports on the development of novel p-on-n thin edgeless planar pixel sensors, compatible with ALICE front-end electronics, fabricated by FBK on epitaxial material. The focus of the activity is the minimization of the material budget required for hybrid pixel detectors. This goal has been addressed in two different stages. In the first one, planar pixel detectors fabricated on epitaxial wafers have been thinned and bonded to the readout chips. The second stage is described by the present paper: the `active edge' concept has been studied for the reduction of the dead area at the periphery of the devices. An overview of the key technological steps and of the electrical characterization of the fabricated sensors is given. In addition, the preliminary results on the static behavior of test sensors after neutron irradiation at different fluences (up to 2.5 × 1015 1 MeV-neq/cm2) are reported. The results demonstrate that these kinds of devices are a viable solution for the reduction of the material budget while maintaining the typical electrical characteristics expected from radiation silicon sensors.

The PICASSO (Phase Imaging for Clinical Application with Silicon detector and Synchrotron radiation) project aims at supplying a digital detector tailored for the clinical trials in mammography with synchrotron radiation that are being performed at the SYRMEP beamline of ELETTRA (Trieste, Italy). The final detector system will comprise four linear array silicon microstrip sensors in “edge-on“ configuration, each 210 mm wide (4224 channels with 50 μm pitch), equipped with a fast single photon counting electronics based on the Mythen-II application-specific integrated circuit. Different prototypes have been tested at the SYRMEP beamline, proving high rate single photon counting capabilities (with negligible losses up to 1.2÷106 incident photons per pixel per second), good mechanical characteristics, and remarkable imaging performances on test-objects.