41 results on '"Oruç, S"'
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2. A characterization of conchoid curves and surfaces in euclidean spaces
- Author
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Oruç, S. Neslihan, Bulca, Betül, and Bursa Uludağ Üniversitesi/Fen Bilimleri Enstitüsü/Matematik Anabilim Dalı.
- Subjects
Conchoid ,Pascal limaçonu ,Surface of revolution ,Dönel yüzey ,Mean curvature ,Gaussian curvature ,Ortalama eğrilik ,Limacons pascal ,Gauss eğriliği - Abstract
Bu tez çalışmasında Öklid uzayındaki conchoid eğrileri ve yüzeyleri ele alınmıştır. Bu tez dört bölümden oluşmaktadır. Birinci bölüm giriş bölümüdür. İkinci bölümde bu çalışmanın ilerleyen bölümlerinde kullanılacak olan Öklid uzayındaki eğri ve yüzeylerle ilgili bazı temel tanımlar ve kavramlar ele alınmıştır. Üçüncü bölümde düzlemde ve 3-boyutlu uzayda conchoid eğrileri tanımlanmıştır. Ayrıca bu eğrilerin eğrilikleri hesaplanıp bunlarla ilgili sonuçlar verilmiştir. Elde edilen sonuçlara göre bazı örnekler verilip grafikleri çizdirilmiştir. Dördüncü bölümde 3 ve 4-boyutlu Öklid uzayında conchoidal yüzeyler çalışılmıştır. İlk olarak 3-boyutlu Öklid uzayında daha önceden verilen conchoidal yüzey tanımına bağlı olarak eğrilikleri ile ilgili sonuçlar elde edilmiştir. Ayrıca 3-boyutlu uzayda bir conchoid eğrisinin döndürülmesi ile elde edilen dönel yüzey ile ilgili sonuçlar verilip grafikleri çizdirilmiştir. Son olarak 4-boyutlu Öklid uzayındaki conchoidal yüzey tanımı verilip bu yüzeylerin düz ve minimal olmaları ile ilgili sonuçlar elde edilmiştir. Ayrıca 4-boyutlu uzayda rotasyonel yüzeyler ve meridyen yüzeylerinin conchoidal yüzey olması örnek olarak verilmiştir. In this thesis, conchoid curves and surfaces in Euclidean space are considered. This thesis consists of four chapters. The first chapter is the introduction. The second chapter contains some well-known definitions and terms about curves and surfaces in Euclidean space which will be used in other chapters. In the third chapter, conchoid curves are defined on plane and 3- dimensional Euclidean space. Furthermore, the curvatures of these curves are calculated and the results are given. According to the results, some examples are given and plot their graphics. In the fourth chapter, conchoidal surfaces are studied in 3 and 4- dimensional Euclidean space. Firstly, in the 3- dimensional Euclidean space, the results of the curvature of the conchoidal surface are obtained. Also, the results are given of the surface of revolution obtained by rotating a planar conchoid curve in 3- dimensional space and are plotted the graphics of the surface. Finally, the definition of the conchoidal surface in the 4- dimensional Euclidean space is given. Also some results are obtained that these surfaces become flat and minimal. In the last part the rotational surfaces in the 4- dimensional space and the meridian surfaces are conchoidal surfaces are given as examples.
- Published
- 2019
3. Conchoid curves and surfaces in Euclidean 3-Space
- Author
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BULCA, Betül, primary, ORUÇ, S. Neslihan, additional, and ARSLAN, Kadri, additional
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- 2018
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4. An evaluation of neuropsychiatric symptoms in Parkinson's disease patients
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Oruç, S, Gülseren, G, Kusbec, O.Y., and Özbulut, O
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Depression, Parkinson’s disease, psychosis - Abstract
Objective: We aimed to examine neuropsychiatric symptoms of patients with early and advanced stage Parkinson’s disease (PD).Materials and Methods: The study was performed at Kocatepe University Neurology Department in Turkey, comprised 46 PD patients and 46 controls. Hoehn-Yahr (HY) scale was used to evaluate the clinical stages of PD and Unified Parkinson’s Disease Rating Scale (UPDRS) was used to evaluate the severity of clinical signs. Cognitive functions were evaluated by Mini-Mental State Examination (MMSE) and neuropsychiatric findings were evaluated by Beck Depression Inventory (BDI), Scale for the Assessment of Positive Symptoms (SAPS), and Scale for the Assessment of Negative Symptoms (SANS).Results: Significant difference was determined between BDI values of patients (13.28 ± 9.04) and control group (9.71 ± 5.19) (P = 0.02). Significant difference was determined with SANS (23.84 ± 15.42, 2.58 ± 3.13, P < 0.001) but not with SAPS (1.36 ± 4.16, 0.15 ± 0.43, P = 0.07). The patients were evaluated according to the HY stages and there was no significant difference between mild and severe symptom groups in respect of BDI, SAPS, and SANS values (P = 0.91, P = 0.31, and P = 0.29). According to gender, no significant difference was found between groups in respect of BDI, SAPS, and SANS values (P = 0.60, P = 0.54, and P = 0.67). No correlation was found between BDI, SAPS, SANS values, and HY stages.Conclusion: Higher rates of depression and negative symptoms were observed in patients with PD compared with healthy individuals. Results did not differ with different stages of PD. Therefore, it should be kept in mind that neuropsychiatric symptoms can be seen from the early stages of the disease and should be treated earlier.Keywords: Depression, Parkinson’s disease, psychosis
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- 2017
5. Effect of accelerated aging on the color stability of feldspathic ceramic treated with various surface treatments.
- Author
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Atay A, Oruç S, Ozen J, and Sipahi C
- Abstract
Objective: To investigate the effect of the accelerated aging process on the color stability of feldspathic ceramic treated with dual ion exchange, overglaze, polishing, and autoglaze surface treatments. Method and Materials: A total of 40 disks (15 mm in diameter and 2 mm thick) of feldspathic ceramic were made in an A2 shade according to the manufacturer's recommendations. The samples were randomly divided into 4 groups: dual ion exchange, overglaze, polishing, and autoglaze. The samples were subjected to conditions in an accelerated aging machine for 150 and 300 hours. Differences in color before and after accelerated aging were calculated using spectrophotometric analyses. Overall color difference (DE) was determined using the CIE L*a*b* system for measuring small color differences. Scanning electron microscopy was used to evaluate the surface texture of samples. Color difference data were evaluated statistically by Kruskal-Wallis and Mann-Whitney U tests, with a significance level of .05. Results: After 150 and 300 hours of accelerated aging, color changes of the 4 surface treatment groups ranged between 0.35 and 1.31 DE units. All DE values were below a quantitative level that would be considered clinically acceptable. Autoglazed samples were the most color stable, followed by ion exchanged, overglazed, and polished test samples. Conclusions: All groups demonstrated color stability below a quantitative level that would be considered clinically acceptable, but long-term clinical studies are necessary to verify these findings. [ABSTRACT FROM AUTHOR]
- Published
- 2008
6. Strategic Behavior in Liberalized Electricity Sectors: Game Theoretical Formal Modeling in Policy Analysis
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Oruç, S. and Thissen, W.A.H.
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game theory ,strategic behavior ,electricity markets ,financial transmission rights ,electricity load shifting ,electricity innovation ,formal modeling - Abstract
The electricity infrastructure, like many other networked infrastructures, is an indispensable and integral part of developed economies. The economic growth, quality of life and general well-being of modern societies all depend on the smooth, reliable and efficient operation of electricity system. On the other hand, adverse strategic behavior by the newly emerged actors in liberalized electricity sectors poses a threat to seamless operation of electricity system. Analyzing strategic behavior is not a straightforward call, even with regard to the non-networked infrastructures. Adding network complexity and the peculiarities of electricity make it even more difficult to analyze strategic behavior. The analysis has to be done with tailored methods that take into account the peculiarities of the underlying system. This study proposes game theoretical formal modeling approach as a way to analyze strategic behavior in liberalized electricity sectors. Three cases that exemplify strategic behavior in liberalized electricity sectors are chosen to be analyzed. For each case, a context of the strategic problem is provided and a game theoretical formal model is created in order to quantitatively conceptualize and represent the strategic problem. The outcomes offer valuable insights into strategic behavior in liberalized electricity sectors and demonstrate the need for ongoing analysis in this domain. This dissertation is the result of Sertaç Oruç’s PhD research at the faculty of Technology, Policy and Management at Delft University of Technology in the Netherlands.
- Published
- 2014
7. Strategic Behavior in Liberalized Electricity Sectors: Game Theoretical Formal Modeling in Policy Analysis
- Author
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Oruç, S. (author) and Oruç, S. (author)
- Abstract
The electricity infrastructure, like many other networked infrastructures, is an indispensable and integral part of developed economies. The economic growth, quality of life and general well-being of modern societies all depend on the smooth, reliable and efficient operation of electricity system. On the other hand, adverse strategic behavior by the newly emerged actors in liberalized electricity sectors poses a threat to seamless operation of electricity system. Analyzing strategic behavior is not a straightforward call, even with regard to the non-networked infrastructures. Adding network complexity and the peculiarities of electricity make it even more difficult to analyze strategic behavior. The analysis has to be done with tailored methods that take into account the peculiarities of the underlying system. This study proposes game theoretical formal modeling approach as a way to analyze strategic behavior in liberalized electricity sectors. Three cases that exemplify strategic behavior in liberalized electricity sectors are chosen to be analyzed. For each case, a context of the strategic problem is provided and a game theoretical formal model is created in order to quantitatively conceptualize and represent the strategic problem. The outcomes offer valuable insights into strategic behavior in liberalized electricity sectors and demonstrate the need for ongoing analysis in this domain. This dissertation is the result of Sertaç Oruç’s PhD research at the faculty of Technology, Policy and Management at Delft University of Technology in the Netherlands., Policy Analysis, Technology, Policy and Management
- Published
- 2014
8. Optimal decentralized Kalman filter
- Author
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Oruç, S., Sijs, J., Bosch, van den, P.P.J., Oruç, S., Sijs, J., and Bosch, van den, P.P.J.
- Abstract
The Kalman filter is a powerful state estimation algorithm which incorporates noise models, process model and measurements to obtain an accurate estimate of the states of a process. Implementation of conventional Kalman filter algorithm requires a central processor that harvests measurements from all the sensors in the field. Central algorithms have some drawbacks such as reliability, robustness and high computation which result in a need for non-central algorithms. This study takes optimality in decentralized Kalman filter (DKF) as its focus and derives the optimal decentralized Kalman filter (ODKF) algorithm, in case the network topology is provided to every node in the network, by introducing global Kalman equations. ODKF sets a lower bound of estimation error in least squares sense for DKF.
- Published
- 2009
9. Bilateral Orbital Hemorrhage Induced by Labor
- Author
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Oruç, S., primary, Şener, E. Cumhur, additional, Akman, A., additional, and Sanaç, A. Şefik, additional
- Published
- 2001
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10. The Pharmacokinetics and Effects of Diltiazem in Rabbits
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Oruç, S., primary, Orhan, D., additional, Orhan, M., additional, Irkeç, M., additional, Başçi, N., additional, Barun, S., additional, and Bozkurt, A., additional
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- 2000
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11. Tu-P9:364 Elastic properties of large arteries in patients with migraine
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Kilit, C., Melek, M., Yaman, M., Taner, A., Oruc, S., Avsar, A., Celik, A., and Onrat, E.
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- 2006
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12. 856Rectus sheath — The ideal grafting material for peyronie's disease?
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Basting, R., Oruc, S., Craatz, S., and Hohenfellner, R.
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- 2005
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13. Incomplete data and technological progress in energy storage technologies
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Oruç, S., Scott Cunningham, Davis, C., and Dorp, B.
14. APPLICATION OF SPECTRAL ANALYSIS TECHNIQUES TO CAVITATION IN CENTRIFUGAL PUMPS
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Eralp, O.C. and Oruc, S.
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- 1993
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15. The histological and biochemical analysis of the effects of radiofrequency radiation on testis tissue of rats and the protective effect of melatonin.
- Author
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Yardim A, Sirav B, Tomruk A, Oruç S, Delen K, Kuzay D, Seymen CM, and Take Kaplanoğlu G
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- Male, Animals, Rats, Antioxidants pharmacology, Malondialdehyde metabolism, Oxidative Stress drug effects, Oxidative Stress radiation effects, Glutathione Peroxidase metabolism, Melatonin pharmacology, Testis radiation effects, Testis drug effects, Rats, Wistar, Radio Waves adverse effects
- Abstract
Background/aim: Primarily due to wireless communication devices, especially mobile phones, there has been a steady rise in the intensity of nonionizing radiofrequency radiation (RFR). In recent years, increased human health problems raised concerns about whether there is a positive relationship between intense exposure to RFR and public health. The present study aims to investigate the effects of GSM-like RFR exposure on the male reproductive system and the impact of melatonin treatment (synergistic, antagonist, or additive)., Materials and Methods: Thirty-six male Wistar Albino rats were used and separated into six groups: i. Control; ii. Sham; iii. RFR exposure; iv. Control-melatonin; v. Sham-melatonin; vi. Melatonin + RFR exposure. Animals were exposed to 2600 MHz RFR with electric (E) field levels of 21.74 V/m for 30 min per day, 5 days per week, for 4 weeks. All testicular tissue samples were evaluated under a light microscope for hematoxylin-eosin staining. Biochemical analyses were performed by measuring malondialdehyde, total nitric oxide, glutathione, and glutathione peroxidase levels. We evaluated the combined effects of prolonged RFR exposure and melatonin treatment on ROS-mediated structural changes in testicular tissues., Results: Results showed that reactive intermediates (malondialdehyde and total nitric oxide) increased significantly with RFR exposure, while the protective effect of melatonin effectively reduced the radical levels of the tissues. Histological evaluation revealed a decrease in cell population and connective tissue elements under RFR exposure, accompanied by marked edema in the testicular tissues., Conclusion: The structural and functional effects of prolonged RFR exposure might be ROS-based. Moreover, these adverse effects might be compensated with externally treated supplements. There is a need for new extensive research., Competing Interests: Conflict of interest: The authors declare that they have no conflicts of interest related to this paper., (© TÜBİTAK.)
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- 2024
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16. Analysis of Spontaneous Movements in Infants With Torticollis.
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Kahraman A, Büğüşan Oruç S, Erdoğan D, and Mutlu A
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- Humans, Infant, Movement, Posture, Torticollis
- Abstract
Purpose: This study aimed to investigate whether the movements and postures of 3- to 5-month-old infants with torticollis differ from those of infants without torticollis and to determine the relationship between clinical characteristics and the Motor Optimality Score (MOS) in torticollis., Methods: Participants were 40 infants with torticollis and 40 infants developing typically without torticollis. The infants were evaluated with detailed general movement assessment., Results: There were significant differences in the MOS and subcategory scores for age-adequate movement repertoire and observed postural patterns between groups. Clinical characteristics were not related to the reduction in the MOS., Conclusions: Infants with torticollis have differences in movements and postures at 3 to 5 months of age compared with controls. Strategies supporting the movement repertoire of infants with torticollis can be added to rehabilitation programs for infants with the lower MOS to optimize their motor development., Competing Interests: The authors declare no conflicts of interest., (Copyright © 2021 Academy of Pediatric Physical Therapy of the American Physical Therapy Association.)
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- 2022
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17. Effects of 2600 MHz Radiofrequency Radiation in Brain Tissue of Male Wistar Rats and Neuroprotective Effects of Melatonin.
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Delen K, Sırav B, Oruç S, Seymen CM, Kuzay D, Yeğin K, and Take Kaplanoğlu G
- Abstract
The debate on the biological effects of radiofrequency radiation (RFR) still continues due to differences in the design of studies (frequency, power density, specific absorption rate [SAR], exposure duration, cell, tissue, or animal type). The current study aimed to investigate the effects of 2,600 MHz RFR and melatonin on brain tissue biochemistry and histology of male rats. Thirty-six rats were divided into six groups randomly: cage-control, sham, RFR, melatonin, sham melatonin, and RFR melatonin. In RFR groups, animals were exposed to 2,600 MHz RFR for 30 days (30 min/day, 5 days/week) and the melatonin group animals were subcutaneously injected with melatonin (7 days/week, 10 mg/kg/day) for 30 days. SAR in brain gray matter was calculated as 0.44 and 0.295 W/kg for 1 and 10 g averaging, respectively. RFR exposure decreased the GSH, GSH-Px, and SOD levels and increased the MPO, MDA, and NOx levels (P < 0.005) significantly. RFR exposure also led to an increase in structural deformation and apoptosis in the brain tissue. This study revealed that exogenous high-dose melatonin could reduce these adverse effects of RFR. Limiting RFR exposure as much as possible is recommended, and taking daily melatonin supplements may be beneficial. Bioelectromagnetics. © 2021 Bioelectromagnetics Society., (© 2021 Bioelectromagnetics Society.)
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- 2021
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18. Evaluation of nutritional behaviour related to COVID-19.
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Elmacıoğlu F, Emiroğlu E, Ülker MT, Özyılmaz Kırcali B, and Oruç S
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- Adult, Body Weight, Emotions, Female, Health Behavior, Humans, Male, Middle Aged, Nutrition Surveys, Pandemics, Retrospective Studies, SARS-CoV-2, Social Isolation, Young Adult, COVID-19 epidemiology, Feeding Behavior, Nutritional Status
- Abstract
Objective: It is known that social isolation process has an impact on individuals' eating behaviours. Continuing nutritional behaviour resulting from emotional eating, uncontrolled eating and cognitive restriction may turn into eating disorders in the future. The purpose of this study is to evaluate the possible effects of Corona Virus Disease-2019 (COVID-19) pandemic and social isolation process on individuals' nutritional behaviours and body weight changes., Design: Retrospective cohort study., Setting: Nutritional behaviours of the participants before the COVID-19 pandemic and in the social isolation process were evaluated with the Three Factor Nutrition Questionnaire. The changes in individuals' body weight during this period were also evaluated., Participants: A total of 1036 volunteer individuals (827 women, 209 men) aged 18 years and over participated in the study., Results: During the COVID-19 pandemic and social isolation process, there was an increase in emotional eating and uncontrolled eating behaviours of individuals, but no significant change in cognitive restriction behaviour occurred (P = <0·00; P = <0·00 and P = 0·53, respectively). It was reported that the body weight of 35 % of the individuals who participated in the study increased during this period., Conclusion: Social isolation process practiced as a result of COVID-19 pandemic may lead to changes in some nutritional behaviours. Some precautions should be taken to prevent this situation that occurs in nutritional behaviours from causing negative health problems in the future.
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- 2021
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19. Analysis of thiol/disulphide homeostasis and oxidant-antioxidant status as a result of exposure to radio-frequency electromagnetic fields.
- Author
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Yavaş MC, Yegin K, Oruç S, Delen K, and Sirav B
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- Animals, Male, Rats, Oxidants blood, Oxidants metabolism, Oxidative Stress radiation effects, Sulfhydryl Compounds blood, Homeostasis radiation effects, Disulfides blood, Electromagnetic Fields adverse effects, Antioxidants metabolism, Rats, Sprague-Dawley, Radio Waves adverse effects
- Abstract
The aim of the current study is to investigate the effect of daily long-term radio-frequency electromagnetic field (RF-EMFs) exposure on thiol/disulphide homeostasis and oxidant-antioxidant status in the serum of rats. Fourteen male Sprague Dawley rats were divided into two equal groups (n = 7). They were grouped as group 1 (sham-control) and group 2 (2100 MHz exposed). Group 2 rats were exposed to GSM-like signals for 5 h/day, 7 days per week for 14 days. In serum of blood samples, the native, total and native/total thiol levels and antioxidant-oxidant parameters were analyzed. The study revealed that the mean serum total thiol levels of GSM exposure group was rather higher than sham-control group ( p = 0,219); the mean serum native thiol levels of GSM exposure group was rather higher than sham-control group ( p = 0,416), and the mean serum disulphide levels of GSM exposure group was rather higher than sham-control group ( p = 0,566). On the other hand, the mean serum total antioxidant status (TAS), total oxidant status (TOS) and oxidative stress index (OSI) of GSM exposure group were higher than sham-control group. There are no data in the literature, that examine the effects of RF-EMFs on thiol/disulphide homeostasis. The results of this study, indicate that RF-EMFs did not cause oxidative stress and statistically changes in thiol/disulphide homeostasis. More sample sizes and longer-term exposures are needed to confirm the results of this study.
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- 2021
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20. Headache as the sole presenting symptom of cerebral venous sinuses thrombosis: Subgroup analysis of data from the VENOST study.
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Duman T, Çınar N, Uludüz D, Domaç FM, Öztürk S, Yayla V, Karahan AY, Afşar N, Sungur MA, Göksu EÖ, Yürekli VA, Genç H, Utku U, Şahin Ş, Tekeli H, Tokuç FE, Uzuner N, Şenol MG, Yılmaz A, Gökçe M, Demirci S, Küsbeci ÖY, Uzuner GT, Batur Çağlayan HZ, Açıkgöz M, Kurucu H, Özdağ MF, Baybaş S, Ekmekçi H, Çabalar M, Yaman M, Bektaş H, Kaplan Y, Göksel BK, Milanlioğlu A, Örken DN, Aluclu MU, Çolakoğlu S, Tüfekçi A, Bakar M, Nazliel B, Tasçılar N, Göksan B, Kozak HH, Mısırlı CH, Küçükoğlu H, Midi İ, Mengüllüoğlu N, Aytaç E, Yeşilot N, İnce B, Yalın OÖ, Güneş T, Oruç S, and Demir S
- Subjects
- Female, Headache etiology, Humans, Male, Prospective Studies, Retrospective Studies, Sinus Thrombosis, Intracranial complications, Sinus Thrombosis, Intracranial diagnostic imaging, Thrombosis
- Abstract
Objectives: Headache is the most common complaint in cerebral venous sinus thrombosis (CVST) and it may sometimes be the only symptom in these patients. This retrospective and prospective study was an investigation of any differences in terms of clinical risk factors, radiological findings, or prognosis in patients with CVST who presented with isolated headache (IH) and cases with other concomitant findings (non-isolated headache [NIH])., Methods: A total of 1144 patients from a multicenter study of cerebral venous sinus thrombosis (VENOST study) were enrolled in this research. The demographic, biochemical, clinical, and radiological aspects of 287 IH cases and 857 NIH cases were compared., Results: There were twice as many women as men in the study group. In the IH group, when gender distribution was evaluated by age group, no statistically significant difference was found. The onset of headache was frequently subacute and chronic in the IH group, but an acute onset was more common in the NIH group. Other neurological findings were observed in 29% of the IH group during follow-up. A previous history of deep, cerebral, or other venous thromboembolism was less common in the IH group than in the NIH group. Transverse sinus involvement was greater in the IH group, whereas sagittal sinus involvement was greater in the NIH group. The presence of a plasminogen activator inhibitor (PAI) mutation was significantly greater in the IH group., Conclusion: IH and CVST should be kept in mind if a patient has subacute or chronic headache. PAI, which has an important role in thrombolytic events, may be a risk factor in CVST. Detailed hematological investigations should be considered. Additional studies are needed.
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- 2021
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21. Medicinal ethnobotany of wild plants: a cross-cultural comparison around Georgia-Turkey border, the Western Lesser Caucasus.
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Kazancı C, Oruç S, and Mosulishvili M
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- Ethnopharmacology, Female, Georgia (Republic), Humans, Knowledge, Male, Middle Aged, Phytotherapy, Plant Preparations, Turkey, Cross-Cultural Comparison, Ethnobotany, Plants, Medicinal classification
- Abstract
Background: The Mountains of the Western Lesser Caucasus with its rich plant diversity, multicultural and multilingual nature host diverse ethnobotanical knowledge related to medicinal plants. However, cross-cultural medicinal ethnobotany and patterns of plant knowledge have not yet been investigated in the region. Doing so could highlight the salient medicinal plant species and show the variations between communities. This study aimed to determine and discuss the similarities and differences of medicinal ethnobotany among people living in highland pastures on both sides of the Georgia-Turkey border., Methods: During the 2017 and 2018 summer transhumance period, 119 participants (74 in Turkey, 45 in Georgia) were interviewed with semi-structured questions. The data was structured in use-reports (URs) following the ICPC classification. Cultural Importance (CI) Index, informant consensus factor (FIC), shared/separate species-use combinations, as well as literature data were used for comparing medicinal ethnobotany of the communities., Results: One thousand five hundred six UR for 152 native wild plant species were documented. More than half of the species are in common on both sides of the border. Out of 817 species-use combinations, only 9% of the use incidences are shared between communities across the border. Around 66% of these reports had not been previously mentioned specifically in the compared literature. Only 33 species have similar use reports in both countries, most important of which are Plantago major, Urtica dioica, Picea orientalis, Anthemis spp., Sambucus ebulus, Achillea millefolium, Helichrysum rubicundum, Mentha longifolia, Pinus sylvestris var. hamata, Hypericum perforatum, Tussilago farfara, Helichrysum plicatum, Rumex crispus, Berberis vulgaris, and Origanum vulgare. More than half of species reported in each country were found to have more than one part of the plant valued for medicinal use. The most common way of using plants medicinally in both countries is drinking the water infusion of aerial parts with flowers. Based on CI index value, two-thirds of the salient 15 genera in both countries have use reports in at least seven medicinal use categories. While the most cited category with highest FIC is digestive in Georgia, it is skin category in Turkey. Patterns of medicinal plant knowledge among studied communities appear to be connected with more than one cultural factor, in particular ethnolinguistic diversity, cultural background, and access to multilingual written folk and scientific literature, or probably a combination of various factors., Conclusion: Considering the regions' floral similarity, common historical-cultural contact, and similar livelihood strategies of the communities, shared ethnomedicinal knowledge across the Georgia-Turkey border is quite low. Even though the impacts of accessing multilingual folk and scientific literature are likely to be significant, the factors that shape the medicinal plant knowledge patterns of the communities are shown to be variable among species, needing further research into intracultural diversity and socio-economical conditions, as well as the political history across the border.
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- 2020
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22. Assessment of Patients with Intracerebral Hemorrhage or Hemorrhagic Transformation in the VENOST Study.
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Duman T, Yayla V, Uludüz D, Özaydın Göksu E, Yürekli VA, Genç H, Utku U, Çınar N, Tekeli H, Sungur MA, Tokuç FE, Uzuner N, Şenol MG, Yılmaz A, Gökçe M, Demirci S, Küsbeci ÖY, Uzuner GT, Şahin Ş, Batur Çağlayan HZ, Açıkgöz M, Özdağ F, Baybaş S, Ekmekçi H, Çabalar M, Yaman M, Bektaş H, Kaplan Y, Göksel BK, Milanlıoğlu A, Necioğlu Örken D, Aluçlu MU, Çolakoğlu S, Tüfekçi A, Bakar M, Nazlıel B, Taşçılar N, Göksan B, Kozak HH, Mısırlı H, Küçükoğlu H, Midi İ, Mengüllüoğlu N, Aytaç E, Yeşilot N, İnce B, Yalın OÖ, Güneş T, Oruç S, Mayda Domaç F, Öztürk Ş, Karahan A, Erdoğan HA, and Afşar N
- Subjects
- Adolescent, Adult, Aged, Female, Humans, Male, Middle Aged, Retrospective Studies, Risk Factors, Young Adult, Cerebral Hemorrhage epidemiology, Cerebral Hemorrhage etiology, Sinus Thrombosis, Intracranial complications, Sinus Thrombosis, Intracranial diagnosis
- Abstract
Introduction: Cerebral venous and sinus thrombosis (CVST) may lead to cerebral edema and increased intracranial pressure; besides, ischemic or hemorrhagic lesions may develop. Intracerebral hemorrhages occur in approximately one-third of CVST patients. We assessed and compared the findings of the cerebral hemorrhage (CH) group and the CVST group., Materials and Methods: In the VENOST study, medical records of 1,193 patients with CVST, aged over 18 years, were obtained from 35 national stroke centers. Demographic characteristics, clinical symptoms, signs at the admission, radiological findings, etiologic factors, acute and maintenance treatment, and outcome results were reported. The number of involved sinuses or veins, localizations of thrombus, and lesions on CT and MRI scans were recorded., Results: CH was detected in the brain imaging of 241 (21.1%) patients, as hemorrhagic infarction in 198 patients and intracerebral hemorrhage in 43 patients. Gynecologic causes comprised the largest percentage (41.7%) of etiology and risk factors in the CVST group. In the CH group, headache associated with other neurological symptoms was more frequent. These neurological symptoms were epileptic seizures (46.9%), nausea and/or vomiting (36.5%), altered consciousness (36.5%), and focal neurological deficits (33.6%). mRS was ≥3 in 23.1% of the patients in the CH group., Discussion and Conclusion: CVST, an important cause of stroke in the young, should be monitored closely if the patients have additional symptoms of headache, multiple sinus involvement, and CH. Older age and parenchymal lesion, either hemorrhagic infarction or intracerebral hemorrhage, imply poor outcome., (© 2020 S. Karger AG, Basel.)
- Published
- 2020
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23. Cerebral Venous Sinus Thrombosis as a Rare Complication of Systemic Lupus Erythematosus: Subgroup Analysis of the VENOST Study.
- Author
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Duman T, Demirci S, Uluduz D, Kozak HH, Demir S, Mısırlı CH, Küçükoğlu H, Çınar N, Domaç FM, Öztürk Ş, Sungur MA, Yayla V, Karahan AY, Afşar N, Göksu EÖ, Aytaç E, Yeşilot N, İnce B, Yalın OÖ, Oruç S, Senol MG, Yılmaz A, Gökçe M, Küsbeci ÖY, Uzuner G, Batur Çağlayan HZ, Açıkgöz M, Kurucu H, Ozdag F, Ekmekci H, Çabalar M, Yurekli VA, Güneş T, Genç H, Utku U, Şahin Ş, Tokuc FEU, Uzuner N, Bektaş H, Kablan Y, Göksel BK, Milanlıoğlu A, Örken DN, Aluclu U, Midi İ, Çolakoğlu S, Tüfekçi A, Bakar M, Nazlıel B, Taşçılar N, and Göksan B
- Subjects
- Adult, Age Distribution, Consciousness Disorders diagnosis, Consciousness Disorders epidemiology, Female, Headache Disorders diagnosis, Headache Disorders epidemiology, Humans, Lupus Erythematosus, Systemic diagnosis, Male, Middle Aged, Prognosis, Prospective Studies, Retrospective Studies, Risk Factors, Sex Distribution, Sinus Thrombosis, Intracranial diagnosis, Time Factors, Turkey epidemiology, Vision Disorders diagnosis, Vision Disorders epidemiology, Lupus Erythematosus, Systemic epidemiology, Sinus Thrombosis, Intracranial epidemiology
- Abstract
Aim: Systemic lupus erythematosus (SLE) is an unusual risk factor for cerebral venous sinus thrombosis (CVST). As few CVST patients with SLE have been reported, little is known regarding its frequency as an underlying etiology, clinical characteristics, or long-term outcome. We evaluated a large cohort of CVST patients with SLE in a multicenter study of cerebral venous thrombosis, the VENOST study, and their clinical characteristics., Material and Method: Among the 1144 CVST patients in the VENOST cohort, patients diagnosed with SLE were studied. Their demographic and clinical characteristics, etiological risk factors, venous involvement status, and outcomes were recorded., Results: In total, 15 (1.31%) of 1144 CVST patients had SLE. The mean age of these patients was 39.9 ± 12.1 years and 13 (86.7%) were female. Presenting symptoms included headache (73.3%), visual field defects (40.0%), and altered consciousness (26.7%). The main sinuses involved were the transverse (60.0%), sagittal (40.0%), and sigmoid (20.0%) sinuses. Parenchymal involvement was not seen in 73.3% of the patients. On the modified Rankin scale, 92.9% of the patients scored 0-1 at the 1-month follow-up and 90.9% scored 0-1 at the 1-year follow-up., Conclusions: SLE was found in 1.31% of the CVST patients, most frequently in young women. Headache was the most common symptom and the CVST onset was chronic in the majority of cases. The patient outcomes were favorable. CVST should be suspected in SLE patients, even in those with isolated chronic headache symptoms with or without other neurological findings., (Copyright © 2019 Elsevier Inc. All rights reserved.)
- Published
- 2019
- Full Text
- View/download PDF
24. Babinski-Nageotte Syndrome Diagnosed in Postpartum Period.
- Author
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Oruç S, Demirbaş H, Güzel A, Beker Acay M, and Yaman M
- Abstract
Babinski-Nageotte Syndrome (BNS) is one of the brainstem syndromes characterized by muscle weakness in the opposite half of the body with classic Wallenberg findings. According to our literature survey, only a few cases have been reported and none of them was in the postpartum period. We report a case of a typical BNS in a postpartum woman with an ischemic lesion in the medulla oblongata shown on magnetic resonance imaging.
- Published
- 2016
- Full Text
- View/download PDF
25. Nerve enlargement after cold exposure: a pilot study with ultrasound imaging.
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Ulaşli AM, Tok F, Karaman A, Yaman F, Dikici O, Oruç S, and Ozçakar L
- Subjects
- Adolescent, Adult, Female, Humans, Male, Median Nerve pathology, Neural Conduction physiology, Pilot Projects, Ultrasonography, Young Adult, Cold Temperature adverse effects, Median Nerve diagnostic imaging
- Abstract
Introduction: Changes of electrophysiogical parameters with regard to cold have been studied intensively but not the morphology of nerves. We explored the effects of cold exposure on median nerve morphology., Methods: Cross-sectional area (CSA) and depth of the right median nerve were assessed at the carpal tunnel and mid-forearm levels before and after 15 min ice-pack application in 34 healthy volunteers., Results: After cooling, mean CSA measurements increased at the carpal tunnel and mid-forearm levels (from 8.00 to 8.85 and 6.64 to 7.55, respectively, P < 0.05); however, the depth values were similar., Conclusions: These preliminary results revealed that cold exposure may cause acute nerve swelling. Further studies with larger samples will be necessary to confirm our findings, to correlate them with electrophysiological data, and to explore when/how the nerve edema resolves., (Copyright © 2013 Wiley Periodicals, Inc.)
- Published
- 2014
- Full Text
- View/download PDF
26. [Effects of COPD on cognitive functions: a case control study].
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Sarınç Ulaşlı S, Oruç S, Günay E, Aktaş O, Akar O, Koyuncu T, and Ünlü M
- Subjects
- Aged, Case-Control Studies, Cognition physiology, Cognition Disorders diagnosis, Female, Humans, Male, Middle Aged, Psychometrics, Pulmonary Disease, Chronic Obstructive psychology, Severity of Illness Index, Cognition Disorders etiology, Health Status, Pulmonary Disease, Chronic Obstructive complications
- Abstract
Introduction: Assessment of disease severity, effects of disease on health status and future events should be considered to direct treatment strategies in chronic obstructive pulmonary disease (COPD) management. Although extrapulmonary effects of COPD are well known, effects of COPD on cognitive functions have not been evaluated sufficiently. therefore we aimed to determine cognitive functions of copd patients in the present study., Materials and Methods: 112 COPD patients with moderate, severe and very severe irreversible airway obstruction and 44 age matched healthy subjects without COPD and systemic diseases as control group were enrolled to the study. Mini mental state examination (MMSE) was performed to evaluate cognitive functions. MMSE results were compared between patient and control groups. Moreover relationship between exacerbation frequency and cognitive functions was evaluated., Results: Total 156 subjects as 112 COPD patients and 44 healthy subjects were included to the study. Mean age of COPD patients was 65.03 ± 7.63 years, and mean age of control group was 63.63 ± 8.96 years (p= 0.364). Mean score of MMSE in COPD patients was 23.8 ± 4.39, and mean score of MMSE in control group was 26.7 ± 2.88. We determined a significant difference in terms of MMSE scores betweeen patient and control group (p< 0.0001). MMSE scores and FEV1 values were significantly different among patients with moderate, sevre and very severe airflow obstruction (p= 0.001; p< 0.0001 respectively). We found a significant negative correlation between MMSE results and exacerbation frequency during last year (p= 0.003; r= -0.239)., Conclusion: Lower MMSE scores of COPD patients than subjects in control group indicates the impairment of cognitive functions in COPD patients. Moreover a negative relationship between MMSE scores with exacerbation frequency during last year suggests that prevention from exacerbation can decrease cognitive impairment in COPD patients. We believe that assessment of cognitive functions and preventive strategies should be considered in COPD management.
- Published
- 2013
- Full Text
- View/download PDF
27. Primary omental pregnancy on the gastrocolic ligament.
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Karaer O, Ilkgül O, and Oruç S
- Subjects
- Adult, Diagnosis, Differential, Female, Humans, Laparotomy, Pregnancy, Pregnancy, Abdominal surgery, Ultrasonography, Omentum, Pregnancy, Abdominal diagnostic imaging
- Abstract
Omental pregnancy is an extremely rare form of abdominal pregnancy. Only 16 cases had been reported in the literature, and most were secondary omental pregnancies. We presented a case of primary omental pregnancy located on "gastrocolic ligament" diagnosed at surgical operation. The aim of this presentation is to remember that pregnancy can exist in unusual localizations, so abdominal observation and examination is very important during operations.
- Published
- 2007
- Full Text
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28. The aromatase inhibitor anastrozole is associated with favorable embryo development and implantation markers in mice ovarian stimulation cycles.
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Karaer O, Vatansever HS, Oruç S, Ozbilgin K, Cilaker S, and Koyuncu MF
- Subjects
- Anastrozole, Animals, Biomarkers, Embryonic Development physiology, Estrous Cycle physiology, Female, Male, Mice, Aromatase Inhibitors pharmacology, Embryonic Development drug effects, Estrous Cycle drug effects, Nitriles pharmacology, Ovulation Induction methods, Triazoles pharmacology
- Abstract
Objective: To investigate the embryonic and endometrial effects of anastrozole in preimplantation and implantation phases in FSH-induced cycles in mice., Design: Blind randomized study., Setting: University research laboratory., Animal(s): Twenty-seven mature female mice., Intervention(s): Single-dose anastrozole (25 mg/kg [0.75 mg]), recombinant FSH (5 IU/mL), and hCG (5 IU/mL) (n = 9); recombinant FSH (5 IU/mL) and hCG (5 IU/mL) (n = 9); or sterile saline (1 mL) (n = 9). The morning of finding the vaginal plug was designated as day 1 of embryonic development (E1). Three mice from each group were sacrificed on E1 and embryos aspirated from uterine tubes. The rest of the mice were sacrificed on E2.5-3 and uteruses removed., Main Outcome Measure(s): Embryo quality, endometrial histologic evaluation, and immunohistochemical analysis of tumor necrosis factor-alpha, leukemia inhibitory factor, laminin, and collagen IV staining., Result(s): Anastrozole use in FSH-induced cycles not only caused an increase in preimplantation receptivity and implantation but also supported release of implantation markers. The enhanced embryo development seen in this study would explain the higher implantation because embryo development is synchronized with endometrial development., Conclusion(s): In mice, the use of anastrozole in FSH-induced cycles has a positive effect on embryo quality and implantation. This effect might be species dependent, and human studies are needed.
- Published
- 2005
- Full Text
- View/download PDF
29. Changes in distribution patterns of integrins in endometrium in copper T380 intrauterine device users.
- Author
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Oruç S, Vatansever HS, Karaer O, Eskicioğlu F, and Narlikuyu B
- Subjects
- Endometrium cytology, Female, Follicular Phase metabolism, Humans, Immunohistochemistry, Luteal Phase metabolism, Menopause metabolism, Endometrium metabolism, Integrin alpha3 metabolism, Integrin alphaV metabolism, Integrin beta1 metabolism, Intrauterine Devices, Copper
- Abstract
Intrauterine contraception is the most cost-effective reversible method of contraception today, but its mechanism of action is not well understood. Our objective was to investigate immunohistochemical distribution patterns of alphav, alpha3, beta1 integrins in women using a copper T380 intrauterine device (IUD) for different periods of time to obtain insight into the role of integrins in intrauterine contraception. Endometrial biopsies were obtained from patients using T Cu380A IUD in follicular and luteal phases and in menopausal women grouped according to the period of time of IUD use (group 1: <3 year, and group 2:>or=3 years). Each group consisted of 10 patients, with a total number of 60 patients. Labelling intensity of all integrins, except for beta1 which increased in the follicular phase, were decreased in women who used IUD for>or=3 years when compared with group 1 in the follicular and luteal phases and in the menopause. We conclude that long-term use of IUD affects integrin expression in endometrium not only in follicular and luteal phases of premenopausal women but also in postmenopausal women. Copper IUD can inhibit binding of integrins to the extracellular matrix and it may cause inhibition of the implantation stage, which is crucial for pregnancy.
- Published
- 2005
- Full Text
- View/download PDF
30. Aromatase inhibitors: possible future applications.
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Karaer O, Oruç S, and Koyuncu FM
- Subjects
- Female, Humans, Aromatase Inhibitors, Breast Neoplasms drug therapy, Enzyme Inhibitors therapeutic use, Neoplasms, Hormone-Dependent drug therapy
- Abstract
In premenopausal women ovaries are the major sites of estrogen production, while in postmenopausal women estrogen is produced by aromatization of ovarian and adrenal androgens in extragonadal sites, mostly in adipose tissue. Aromatase is a cytochrome P450 hemoprotein-containing enzyme complex that catalyzes the rate-limiting step in the conversion of androstenedione and testosterone to estrone and estradiol (E2). Aromatase inhibitors (AIs) have been developed primarily for use in either natural or surgical postmenopausal patients. In premenopausal women, the ovary can overcome the estrogen blockade by reflex increments of luteinizing hormone (LH) and follicle stimulating hormone (FSH), so AIs must be combined with a gonadotropin releasing hormone (GnRH) agonist to prevent the reflex LH and FSH increments. In advanced hormone-dependent breast cancer treatment, AIs have been shown to be superior to tamoxifen. Preliminary evidence also suggests superiority in the adjuvant, neoadjuvant settings and also for breast cancer prevention. AIs have been used in infertility and can increase ovulation rate. Reducing FSH dose, estrogen levels, improving response to FSH, implantation rates, and developing multiple follicles that can be used in in vitro maturation procedures are potential areas that AIs might be used in in assisted reproductive technologies (ART), besides simple ovulation induction. AIs are reported to be successful in treatment of endometriosis, an estrogen-dependent process. The use of AIs in gynecomastia, puberte precox, leiomyoma uteri, some estrogen-dependent cancers (ovarian), endometrial cancer and male infertility are reported; some of the results are promising but more clinical trials are needed. AIs are predicted to become the gold standard in the treatment of estrogen-dependent diseases in reproductive medicine in the near future.
- Published
- 2004
- Full Text
- View/download PDF
31. Coexistence of a prolapsed, pedunculated cervical myoma and pregnancy complications: a case report.
- Author
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Oruç S, Karaer O, and Kurtul O
- Subjects
- Abortion, Induced methods, Adult, Female, Fetal Death surgery, Humans, Hysterectomy methods, Myoma complications, Pregnancy, Prolapse, Uterine Cervical Neoplasms complications, Fetal Death etiology, Fetal Membranes, Premature Rupture complications, Myoma surgery, Pregnancy Complications, Neoplastic, Uterine Cervical Neoplasms surgery
- Abstract
Background: Different types of fibroids may affect reproductive outcome to a different extent, causing infertility and pregnancy wastage. Rectosigmoid compression, prolapse of a pedunculated submucous tumor through the cervix, venous stasis, polycythemia and ascites are infrequently associated with leiomyomas. Uterine leiomyomas arefound in approximately 2% of pregnant women; 1 in 10 causes complications during pregnancy., Case: A 37-year-old woman, gravida 3, para 2, abortion 0, at 18 weeks of pregnancy, arrived at our outpatient clinic with a complaint of leaking vaginal fluid. On examination, a prolapsed, pedunculated myoma, measuring 5 x 6 x 7 cm, and pooling of amniotic fluid in the vaginal fornix were detected. Antibiotics were started, but the amniotic fluid leak continued, and the fetal heart beat became undetectable after 12 hours of hospitalization. We tried to excise the myoma from the vagina but because it was very large, we could not reach the proximal point it originatedfrom. We dissected the posterior cervical channel, removed the myoma and performed a total abdominal hysterectomy., Conclusion: Vaginal myomectomy is recommended as the initial treatment of choicefor a prolapsed, pedunculated submucous myoma except when other indications necessitate an abdominal approach. Use of Laminaria and hysteroscopic resection has been mentioned as other treatment choices. In our case a prolapsed, pedunculated cervical myoma was detected along with pregnancy complications, preterm premature rupture of membranes and fetal death. The cause-and-effect relationship between the prolapsed myoma and membrane rupture is unknown. We were unable to perform a vaginal or abdominal myomectomy because the myoma originated in the posterior cervical region, so we had to perform an abdominal hysterectomy.
- Published
- 2004
32. Atherogenic profile in preeclampsia.
- Author
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Var A, Kuşcu NK, Koyuncu F, Uyanik BS, Onur E, Yildirim Y, and Oruç S
- Subjects
- Adult, Case-Control Studies, Female, Humans, Pregnancy, Apolipoprotein A-I blood, Apolipoproteins B blood, Arteriosclerosis blood, Lipoprotein(a) blood, Malondialdehyde blood, Pre-Eclampsia blood
- Abstract
Atherosis is accepted to underlie the pathogenesis of preeclampsia, therefore we aimed to determine malonyldialdehyde (MDA) levels as a marker of lipid peroxidation, and lipoprotein(a) (Lp(a)), apolipoprotein A-1 (Apo A-1) and apolipoprotein B (Apo B) levels as a marker of atherogenic profile in preeclamptic and normal pregnant women. Twenty preeclamptic and 20 gestational-age matched normal pregnant patients were enrolled in the study, mean gestational ages for the preeclamptic and the control group were 33.9+/-1.4 and 35.5+/-0.7 weeks, respectively. Blood was withdrawn from the patients soon after diagnosis, and from the controls at their routine prenatal visits. MDA levels was significantly higher in preeclamptic patients (P=0.0003), but no difference was observed in Apo A-1 and Apo B and Lp(a) levels between the 2 groups. We consider that higher MDA was due to oxidative stress seen in preeclampsia, and similar Apo A-1 and Apo B and Lp(a) levels were due to lack of systemic atherosis.
- Published
- 2003
- Full Text
- View/download PDF
33. Relationship of sexuality with psychological and hormonal features in the menopausal period.
- Author
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Danaci AE, Oruç S, Adigüzel H, Yildirim Y, and Aydemir O
- Subjects
- Adult, Age Factors, Anxiety metabolism, Coitus physiology, Coitus psychology, Cross-Sectional Studies, Depression metabolism, Female, Follicle Stimulating Hormone metabolism, Gonadal Steroid Hormones metabolism, Humans, Luteinizing Hormone metabolism, Middle Aged, Psychometrics, Statistics as Topic, Turkey, Women's Health, Anxiety physiopathology, Anxiety psychology, Depression physiopathology, Depression psychology, Gonadal Steroid Hormones physiology, Menopause physiology, Menopause psychology, Sexuality physiology, Sexuality psychology
- Abstract
Women may experience some mental and sexual problems between the ages of 40 years and 60 years due to serious changes in the hormonal system. The aim of this study was to examine the relationships between the changes in sex hormones, sexual behaviours, depression and anxiety levels of women who were in either the premenopausal, perimenopausal or postmenopausal period. The subjects of this cross-sectional study consisted of 324 women who attended the Gynaecology and Obstetrics Out-Patient Ward of Celal Bayar University Hospital. Of this group, 37.0% (n = 124) were postmenopausal, 27.2% (n = 84) perimenopausal and 35.8% (n = 116) premenopausal. Beck Depression Inventory (BDI), State and Trait Anxiety Inventories (STAI-I and II) and a questionnaire on sexual behaviour which was prepared for this study by the authors, were applied to all of the attendees and serum sex hormone levels were analyzed. Beck Depression Anxiety, STAI-I and STAI-II scores and sexual behaviours did not show any statistically significant difference among these three groups. The frequency of sexual intercourse was lower in women with high BDI scores. The rate of painful intercourse was higher in women with high STAI-I scores. The frequency of sexual intercourse, sexual desire and orgasm decreased and painful intercourse increased in women with high STAI-II scores. The frequency of sexual intercourse decreased significantly as the age or follicle stimulating hormone level of women increased. These findings have revealed that the menopausal state did not affect the sexual behaviour, and psychological state of women between the ages of 40 and 60 years, but the increase in anxiety and depression scores affected the sexual life in a negative manner.
- Published
- 2003
34. Handmade fixed partial prosthesis remover.
- Author
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Oruç S
- Subjects
- Humans, Denture, Partial, Fixed, Device Removal instrumentation
- Published
- 2002
- Full Text
- View/download PDF
35. Assessment of the effectiveness of postmenopausal tibolone therapy on neural functions by measuring visual evoked potentials: a placebo-controlled study.
- Author
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Laçin S, Oruç S, Karaca S, Kusçu K, Koyuncu F, Uyar Y, and Caglar H
- Subjects
- Anabolic Agents pharmacology, Female, Humans, Middle Aged, Norpregnenes pharmacology, Occipital Lobe physiology, Placebos, Retina physiology, Synaptic Transmission drug effects, Visual Pathways drug effects, Visual Pathways physiology, Anabolic Agents therapeutic use, Evoked Potentials, Visual drug effects, Hormone Replacement Therapy, Norpregnenes therapeutic use, Postmenopause
- Abstract
Objective: To assess the effect of hormone replacement therapy on neural transmission in postmenopausal women using tibolone by a non-invasive, objective way., Study Design: In a randomised, 3 cycle, placebo-controlled study, neurovisual transmission in optic pathways were evaluated by measuring visual evoked potentials (VEP). After neuroophtalmologic examination, eligible subjects were randomised into two groups. Treatment group (n=38) were given tibolone 2.5mg daily continuously for 3 months and control group (n=20) were treated with placebo. A baseline VEP measurement before the treatment and then at the end of first, second and third month were obtained by the EMG-evoked system in the Department of Neurology, University of Celal Bayar, Manisa, Turkey., Results: Data from 31 women from treatment group and 16 from control group were available for evaluation. The mean P(100) latency values, which indicate the transition time period between the optic stimuli and electrical change recorded on the occipital area by the skin electrodes, have showed a significant decrease for the study group (from 100.39+/-0.58 to 97.90+/-0.65 ms, P<0.01) at the end of the first month of treatment according to the baseline values. This difference between two groups has remained constant during the study period., Conclusion: The change in latency measurements of VEP, reflecting the functional status in optic pathways from retina to occipital cortex were significantly different in the treatment group than in that of control. We concluded that a facilitating effect of tibolone was observed on neurovisual transmission.
- Published
- 2001
- Full Text
- View/download PDF
36. Changes in the plasma activities of protein C and protein S during pregnancy.
- Author
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Oruç S, Saruç M, Koyuncu FM, and Ozdemir E
- Subjects
- Cross-Sectional Studies, Female, Humans, Plasma Volume, Postpartum Period blood, Pregnancy Complications, Hematologic blood, Pregnancy Complications, Hematologic diagnosis, Pregnancy Trimester, First blood, Pregnancy Trimester, Second blood, Pregnancy Trimester, Third blood, Prospective Studies, Protein C analysis, Protein C Deficiency blood, Protein C Deficiency diagnosis, Protein S analysis, Protein S Deficiency blood, Protein S Deficiency diagnosis, Reference Values, Reproducibility of Results, Thromboembolism blood, Thromboembolism diagnosis, Pregnancy blood, Protein C metabolism, Protein S metabolism
- Abstract
The objective of the study was to determine the changes in the plasma activities of protein C and protein S that occur during normal pregnancy In this prospective cross-sectional study, plasma activities of protein C and protein S were measured in 32 normal pregnant women in the first, second and third trimester and 6 weeks after delivery There was a significant fall in protein C and protein S activities during normal pregnancy compared with the post-puerperal period. The activities of protein C and protein S also gradually decreased throughout pregnancy (p < 0.01). Increasing plasma volume during normal pregnancy and its dilutional effect might play some role in the low activities of protein S observed. The normal falls in protein S and protein C activities make it difficult to diagnose protein S and C deficiency during pregnancy. Based on our findings, if a woman has a thromboembolic event during pregnancy, testing for a definitive diagnosis of protein C or protein S deficiency or functional failure should be delayed until at least 6 weeks postpartum.
- Published
- 2000
- Full Text
- View/download PDF
37. Fit of titanium and a base metal alloy metal-ceramic crown.
- Author
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Oruç S and Tulunoglu Y
- Subjects
- Analysis of Variance, Ceramics chemistry, Dental Casting Investment chemistry, Dental Porcelain chemistry, Dental Prosthesis Design, Hot Temperature, Humans, Materials Testing, Microscopy, Electron, Scanning, Surface Properties, Tooth Preparation, Prosthodontic, Chromium Alloys chemistry, Crowns, Metal Ceramic Alloys chemistry, Titanium chemistry
- Abstract
Statement of Problem: Titanium has been widely used in dental implantology. However, problems remain for use of titanium in prosthodontics., Purpose: This study evaluated the marginal and inner fit of metal-ceramic restorations and frameworks made with a nickel-chromium alloy (Remanium CS) and a commercially pure titanium (Rematitan). Fit was compared with SEM before and after firing of ceramic materials., Material and Methods: Sixteen metal frameworks were cast with each casting material, 8 frameworks were used directly to evaluate measurements for fit (RCS: Remanium CS frameworks and TI: Rematitan frameworks). Porcelain was applied on the other 8 frameworks (RCSP: Remanium CS-porcelain and TIP: Rematitan-porcelain), fired, and then the fit was measured. Measurements were recorded at 3 points for marginal fit evaluation and at 3 points for inner fit., Results: Significant differences were recorded among the occlusal (JK) values of groups tested (P <.05). Marginal fit and inner fit of Remanium CS frameworks were better than Rematitan frameworks. However, there were no substantial differences detected among groups after firing the ceramic superstructures., Conclusion: The fit of the base metal alloy metal-ceramic crowns was better than the commercially pure titanium metal-ceramic crowns. However, both artificial crowns were clinically acceptable.
- Published
- 2000
- Full Text
- View/download PDF
38. Investigation of microleakage between titanium and porcelain.
- Author
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Oruç S and Kama B
- Subjects
- Dental Porcelain, Dental Prosthesis Design, Statistics, Nonparametric, Titanium, Dental Leakage, Metal Ceramic Alloys
- Abstract
Porcelain was applied to 30 titanium and 30 Remanium CS disc-shaped frameworks in order to investigate the microleakage. Each group was divided to three subgroups each containing 10 specimens and representing the different firing cycles (10 specimens for opaque + dentine; 10 specimens for opaque + dentine + enamel; and 10 specimens for opaque + dentine + enamel porcelain + glaze application). All the specimens were stored in 37 degrees C distilled water for 2 weeks and subjected to 100 thermocycles between 5 and 55 degrees C with 30 s dwell time. The specimens were then stored in 5% basic fuchsin dye for 2 days. The washed, rinsed and air dried specimens were embedded in autopolymerizing resin and sectioned diametrically. The stereoptical investigations were performed by three independent investigators. The data were analysed by the Mann-Whitney U-test. The statistical analysis revealed that the different number of firings does not affect the amount of microleakage. However, it should be emphasized that the use of titanium would be beneficial regarding the relatively lower values obtained from the titanium-porcelain group.
- Published
- 1999
- Full Text
- View/download PDF
39. Sexual behaviour during pregnancy.
- Author
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Oruç S, Esen A, Laçin S, Adigüzel H, Uyar Y, and Koyuncu F
- Subjects
- Adolescent, Adult, Coitus, Female, Humans, Life Change Events, Socioeconomic Factors, Surveys and Questionnaires, Dyspareunia etiology, Pregnancy physiology, Pregnancy psychology, Pregnancy Complications etiology, Sexual Behavior physiology, Sexual Behavior psychology, Sexual Dysfunctions, Psychological etiology
- Abstract
The effects of pregnancy on sexuality were studied in 158 pregnant women. They were surveyed by questionnaire about sociodemographic variables and sexual behaviour. Dyspareunia was common in our study group during pregnancy. Pregnancy had a negative effect on orgasmic quality. Dyspareunia and orgasmic quality influenced coital frequency. Coital frequency declined as the month of the pregnancy increased. Pregnancy is a potent influence on sexuality irrespective of an individual's conditioning.
- Published
- 1999
- Full Text
- View/download PDF
40. A comparative study on the effects of apraclonidine and timolol on the ophthalmic blood flow velocity waveforms.
- Author
-
Oruç S and Sener EC
- Subjects
- Adrenergic alpha-Agonists administration & dosage, Adrenergic beta-Antagonists administration & dosage, Adult, Blood Flow Velocity drug effects, Blood Pressure drug effects, Clonidine administration & dosage, Cross-Over Studies, Double-Blind Method, Female, Humans, Intraocular Pressure drug effects, Male, Ophthalmic Artery diagnostic imaging, Ophthalmic Artery drug effects, Ophthalmic Solutions, Prospective Studies, Reference Values, Retinal Artery diagnostic imaging, Retinal Artery drug effects, Timolol administration & dosage, Ultrasonography, Doppler, Adrenergic alpha-Agonists pharmacology, Adrenergic beta-Antagonists pharmacology, Clonidine analogs & derivatives, Clonidine pharmacology, Ophthalmic Artery physiology, Retinal Artery physiology, Timolol pharmacology
- Abstract
Purpose: To evaluate the effects of topical timolol and apraclonidine on retrobulbar blood flow velocity waveforms in a group of healthy volunteers., Methods: Apraclonidine 1% and timolol maleate 0.5% single dose administrations were crossed over double masked in 12 healthy volunteers. The intraocular pressure measurements were followed by Doppler examination of the ophthalmic artery and the central retinal artery., Results: Intraocular pressure was reduced significantly on both treated and fellow eyes after timolol (p = 0.003, p = 0.04 respectively) and after apraclonidine (p = 0.002, p = 0.01 respectively). After apraclonidine administration end diastolic velocity, mean velocity decreased and pulsatility index increased in the ophthalmic artery of both treated and fellow eyes. Resistivity index increased and peak systolic velocity decreased only in the ophthalmic artery of treated eyes. All Doppler indices remained nonsignificant for central retinal artery of both eyes. After timolol administration there were no significant changes of the Doppler indices in the ophthalmic artery and central retinal artery of the treated and fellow eyes., Conclusion: Topical timolol and apraclonidine significantly reduced the intraocular pressure. Single dose administration of apraclonidine 1% increased the vascular impedance distal to the ophthalmic artery. On the other hand, timolol 0.5% had no effect on vascular impedance.
- Published
- 1999
- Full Text
- View/download PDF
41. Myxoid leiomyosarcoma of the uterus: a case report.
- Author
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Oruç S, Koyuncu F, and Gürbüz N
- Subjects
- Fallopian Tubes surgery, Female, Humans, Hysterectomy, Middle Aged, Ovariectomy, Leiomyosarcoma pathology, Leiomyosarcoma surgery, Uterine Neoplasms pathology, Uterine Neoplasms surgery
- Published
- 1999
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