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5 results on '"Ortolani, Giorgia"'

1. Ultrafast structural changes direct the first molecular events of vision

Author

Gruhl, Thomas, Weinert, Tobias, Rodrigues, Matthew J., Milne, Christopher J., Ortolani, Giorgia, Nass, Karol, Nango, Eriko, Sen, Saumik, Johnson, Philip J. M., Cirelli, Claudio, Furrer, Antonia, Mous, Sandra, Skopintsev, Petr, James, Daniel, Dworkowski, Florian, Båth, Petra, Kekilli, Demet, Ozerov, Dmitry, Tanaka, Rie, Glover, Hannah, Bacellar, Camila, Brünle, Steffen, Casadei, Cecilia M., Diethelm, Azeglio D., Gashi, Dardan, Gotthard, Guillaume, Guixà-González, Ramon, Joti, Yasumasa, Kabanova, Victoria, Knopp, Gregor, Lesca, Elena, Ma, Pikyee, Martiel, Isabelle, Mühle, Jonas, Owada, Shigeki, Pamula, Filip, Sarabi, Daniel, Tejero, Oliver, Tsai, Ching-Ju, Varma, Niranjan, Wach, Anna, Boutet, Sébastien, Tono, Kensuke, Nogly, Przemyslaw, Deupi, Xavier, Iwata, So, Neutze, Richard, Standfuss, Jörg, Schertler, Gebhard, and Panneels, Valerie

Published
2023
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2. Time-resolved serial crystallography to track the dynamics of carbon monoxide in the active site of cytochrome c oxidase

Author

Safari, Cecilia, primary, Ghosh, Swagatha, additional, Andersson, Rebecka, additional, Johannesson, Jonatan, additional, Båth, Petra, additional, Uwangue, Owens, additional, Dahl, Peter, additional, Zoric, Doris, additional, Sandelin, Emil, additional, Vallejos, Adams, additional, Nango, Eriko, additional, Tanaka, Rie, additional, Bosman, Robert, additional, Börjesson, Per, additional, Dunevall, Elin, additional, Hammarin, Greger, additional, Ortolani, Giorgia, additional, Panman, Matthijs, additional, Tanaka, Tomoyuki, additional, Yamashita, Ayumi, additional, Arima, Toshi, additional, Sugahara, Michihiro, additional, Suzuki, Mamoru, additional, Masuda, Tetsuya, additional, Takeda, Hanae, additional, Yamagiwa, Raika, additional, Oda, Kazumasa, additional, Fukuda, Masahiro, additional, Tosha, Takehiko, additional, Naitow, Hisashi, additional, Owada, Shigeki, additional, Tono, Kensuke, additional, Nureki, Osamu, additional, Iwata, So, additional, Neutze, Richard, additional, and Brändén, Gisela, additional

Published
2023
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3. Ultrafast structural changes direct the first molecular events of vision

Author

60452330, Gruhl, Thomas, Weinert, Tobias, Rodrigues, Matthew J., Milne, Christopher J., Ortolani, Giorgia, Nass, Karol, Nango, Eriko, Sen, Saumik, Johnson, Philip J. M., Cirelli, Claudio, Furrer, Antonia, Mous, Sandra, Skopintsev, Petr, James, Daniel, Dworkowski, Florian, Båth, Petra, Kekilli, Demet, Ozerov, Dmitry, Tanaka, Rie, Glover, Hannah, Bacellar, Camila, Brünle, Steffen, Casadei, Cecilia M., Diethelm, Azeglio D., Gashi, Dardan, Gotthard, Guillaume, Guixà-González, Ramon, Joti, Yasumasa, Kabanova, Victoria, Knopp, Gregor, Lesca, Elena, Ma, Pikyee, Martiel, Isabelle, Mühle, Jonas, Owada, Shigeki, Pamula, Filip, Sarabi, Daniel, Tejero, Oliver, Tsai, Ching-Ju, Varma, Niranjan, Wach, Anna, Boutet, Sébastien, Tono, Kensuke, Nogly, Przemyslaw, Deupi, Xavier, Iwata, So, Neutze, Richard, Standfuss, Jörg, Schertler, Gebhard, Panneels, Valerie, 60452330, Gruhl, Thomas, Weinert, Tobias, Rodrigues, Matthew J., Milne, Christopher J., Ortolani, Giorgia, Nass, Karol, Nango, Eriko, Sen, Saumik, Johnson, Philip J. M., Cirelli, Claudio, Furrer, Antonia, Mous, Sandra, Skopintsev, Petr, James, Daniel, Dworkowski, Florian, Båth, Petra, Kekilli, Demet, Ozerov, Dmitry, Tanaka, Rie, Glover, Hannah, Bacellar, Camila, Brünle, Steffen, Casadei, Cecilia M., Diethelm, Azeglio D., Gashi, Dardan, Gotthard, Guillaume, Guixà-González, Ramon, Joti, Yasumasa, Kabanova, Victoria, Knopp, Gregor, Lesca, Elena, Ma, Pikyee, Martiel, Isabelle, Mühle, Jonas, Owada, Shigeki, Pamula, Filip, Sarabi, Daniel, Tejero, Oliver, Tsai, Ching-Ju, Varma, Niranjan, Wach, Anna, Boutet, Sébastien, Tono, Kensuke, Nogly, Przemyslaw, Deupi, Xavier, Iwata, So, Neutze, Richard, Standfuss, Jörg, Schertler, Gebhard, and Panneels, Valerie

Abstract

Vision is initiated by the rhodopsin family of light-sensitive G protein-coupled receptors (GPCRs). A photon is absorbed by the 11-cis retinal chromophore of rhodopsin, which isomerizes within 200 femtoseconds to the all-trans conformation, thereby initiating the cellular signal transduction processes that ultimately lead to vision. However, the intramolecular mechanism by which the photoactivated retinal induces the activation events inside rhodopsin remains experimentally unclear. Here we use ultrafast time-resolved crystallography at room temperature to determine how an isomerized twisted all-trans retinal stores the photon energy that is required to initiate the protein conformational changes associated with the formation of the G protein-binding signalling state. The distorted retinal at a 1-ps time delay after photoactivation has pulled away from half of its numerous interactions with its binding pocket, and the excess of the photon energy is released through an anisotropic protein breathing motion in the direction of the extracellular space. Notably, the very early structural motions in the protein side chains of rhodopsin appear in regions that are involved in later stages of the conserved class A GPCR activation mechanism. Our study sheds light on the earliest stages of vision in vertebrates and points to fundamental aspects of the molecular mechanisms of agonist-mediated GPCR activation.

Published
2023

4. ULTRAFAST STRUCTURAL CHANGES DIRECT THE FIRST MOLECULAR EVENTS OF VISION

Author

Gruhl, Thomas, primary, Weinert, Tobias, additional, Rodrigues, Matthew, additional, Milne, Christopher J, additional, Ortolani, Giorgia, additional, Nass, Karol, additional, Nango, Eriko, additional, Sen, Saumik, additional, Johnson, Philip J M, additional, Cirelli, Claudio, additional, Furrer, Antonia, additional, Mous, Sandra, additional, Skopintsev, Petr, additional, James, Daniel, additional, Dworkowski, Florian, additional, Båth, Petra, additional, Kekilli, Demet, additional, Ozerov, Dmitry, additional, Tanaka, Rie, additional, Glover, Hannah, additional, Bacellar, Camila, additional, Brünle, Steffen, additional, Casadei, Cecilia M, additional, Diethelm, Azeglio D, additional, Gashi, Dardan, additional, Gotthard, Guillaume, additional, Guixà-González, Ramon, additional, Joti, Yasumasa, additional, Kabanova, Victoria, additional, Knopp, Gregor, additional, Lesca, Elena, additional, Ma, Pikyee, additional, Martiel, Isabelle, additional, Mühle, Jonas, additional, Owada, Shigeki, additional, Pamula, Filip, additional, Sarabi, Daniel, additional, Tejero, Oliver, additional, Tsai, Ching-Ju, additional, Varma, Niranjan, additional, Wach, Anna, additional, Boutet, Sébastien, additional, Tono, Kensuke, additional, Nogly, Przemyslaw, additional, Deupi, Xavier, additional, Iwata, So, additional, Neutze, Richard, additional, Standfuss, Jörg, additional, Schertler, Gebhard FX, additional, and Panneels, Valerie, additional

Published
2022
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5. Lipidic cubic phase serial femtosecond crystallography structure of a photosynthetic reaction centre

Author

Båth, Petra, primary, Banacore, Analia, additional, Börjesson, Per, additional, Bosman, Robert, additional, Wickstrand, Cecilia, additional, Safari, Cecilia, additional, Dods, Robert, additional, Ghosh, Swagatha, additional, Dahl, Peter, additional, Ortolani, Giorgia, additional, Björg Ulfarsdottir, Tinna, additional, Hammarin, Greger, additional, García Bonete, María-José, additional, Vallejos, Adams, additional, Ostojić, Lucija, additional, Edlund, Petra, additional, Linse, Johanna-Barbara, additional, Andersson, Rebecka, additional, Nango, Eriko, additional, Owada, Shigeki, additional, Tanaka, Rie, additional, Tono, Kensuke, additional, Joti, Yasumasa, additional, Nureki, Osamu, additional, Luo, Fangjia, additional, James, Daniel, additional, Nass, Karol, additional, Johnson, Philip J. M., additional, Knopp, Gregor, additional, Ozerov, Dmitry, additional, Cirelli, Claudio, additional, Milne, Christopher, additional, Iwata, So, additional, Brändén, Gisela, additional, and Neutze, Richard, additional

Published
2022
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