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3. Tumors: Oto-Rhino-Laryngology

Author

Guigay, Joël, Ortholan, C., Auperin, A., Le Caer, H., Michel, C., Mertens, C., Hofman, Paul, Section editor, Boulahssass, Rabia, Section editor, Gu, Danan, editor, and Dupre, Matthew E., editor

Published
2021
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23. [Functional stereotactic radiosurgery: Indications and perspectives]

Author

Dupic, G., Biau, J., Lemaire, J.J., Ortholan, C., Clavelou, Pierre, Lapeyre, M., Colin, P., Khalil, T., Centre Jean Perrin [Clermont-Ferrand] (UNICANCER/CJP), UNICANCER, Imagerie Moléculaire et Stratégies Théranostiques (IMoST), Université Clermont Auvergne [2017-2020] (UCA [2017-2020])-Institut National de la Santé et de la Recherche Médicale (INSERM), Institute of Developmental Biology and Cancer (IBDC), Université Nice Sophia Antipolis (... - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Centre National de la Recherche Scientifique (CNRS)-Université Côte d'Azur (UCA), Service de Neurologie [CHU Clermont-Ferrand], CHU Gabriel Montpied [Clermont-Ferrand], CHU Clermont-Ferrand-CHU Clermont-Ferrand-CHU Estaing [Clermont-Ferrand], CHU Clermont-Ferrand, Service de Radiothérapie (CLERMONT FERRAND - Radiothérapie), DRAAF CENTRE FRA, Partenaires IRSTEA, Institut national de recherche en sciences et technologies pour l'environnement et l'agriculture (IRSTEA)-Institut national de recherche en sciences et technologies pour l'environnement et l'agriculture (IRSTEA), École Centrale de Nantes (ECN), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Clermont Auvergne [2017-2020] (UCA [2017-2020]), and Université Nice Sophia Antipolis (1965 - 2019) (UNS)

Subjects
Depressive Disorder, Major, Obsessive-Compulsive Disorder, Névralgie du trijumeau, Epilepsy, Sclerosis, [SDV]Life Sciences [q-bio], education, Stereotactic Radiosurgery, [SDV.CAN]Life Sciences [q-bio]/Cancer, Parkinson Disease, Radiotherapy Dosage, Trigeminal Neuralgia, Radiosurgery, Tremblement, Treatment Outcome, parasitic diseases, Stéréotaxie, Tremor, Humans, Radiochirurgie, Épilepsie
Abstract

International audience; Stereotactic radiosurgery (SRS) is a non-invasive technique that enables to create brain focal lesions with a high precision and localization. Thus, functional brain disorders can be treated by SRS in case of pharmacoresistance or inoperability. To date, treatment of trigeminal neuralgia is the most described and known indication. Other indications will be developed in the future like movement disorders, refractory epilepsy, obsessive compulsive disorder and severe depression. We present here a review of actual and future indications of functional brain SRS with their level of evidence. All these SRS treatments have to be strictly conducted by trained teams with an excellent collaboration between radiation physicists, medical physicists, neurosurgeons, neurologists, psychiatrists and probably neuroradiologists.

Published
2019

24. Personalized treatment according to geriatric assessment in first-line recurrent and/or metastatic (R/M) head and neck squamous cell cancer (HNSCC) patients aged 70 or over: ELAN (ELderly heAd and Neck cancer) FIT and UNFIT trials

Author

Guigay, J., primary, Auperin, A., additional, Mertens, C., additional, Even, C., additional, Geoffrois, L., additional, Cupissol, D., additional, Rolland, F., additional, Sire, C., additional, Fayette, J., additional, Peyrade, F., additional, Blot, E., additional, Debourdeau, P., additional, Bozec, L., additional, Capitain, O., additional, Pointreau, Y., additional, Brard, C., additional, Michel, C., additional, Schwob, D., additional, Ortholan, C., additional, and Le Caer, H., additional

Published
2019
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25. Multidisciplinary development of the Geriatric Core Dataset for clinical research in older patients with cancer: A French initiative with international survey

Author

Paillaud, E., primary, Soubeyran, P., additional, Caillet, P., additional, Cudennec, T., additional, Brain, E., additional, Terret, C., additional, Etchepare, F., additional, Mourey, L., additional, Aparicio, T., additional, Pamoukdjian, F., additional, Audisio, R.A., additional, Rostoft, S., additional, Hurria, A., additional, Bellera, C., additional, Mathoulin-Pélissier, S., additional, Boulahssass, R., additional, De Decker, L., additional, Fossey-Diaz, V., additional, Liuu, E., additional, Mertens, C., additional, Balardy, L., additional, Retornaz, F., additional, Couderc, A.L., additional, Rollot-Trad, F., additional, Azria, D., additional, Bacciarello, G., additional, Barranger, E., additional, Bengrine, L., additional, Bernat-Piazza, L., additional, Blay, J.Y., additional, Bourdolle, E., additional, Carola, E., additional, Chinot, O., additional, Classe, J.M., additional, Corre, R., additional, Culine, S., additional, Cure, H., additional, Delaloge S, S., additional, Delattre, J.Y., additional, Desolneux, G., additional, Freyer, G., additional, Graff, P., additional, Guigay, J., additional, Herlin, C., additional, Hoang-Xuan, K., additional, Italiano, A., additional, Kurtz, J.E., additional, Lartigau, E., additional, Lazarovicci-Nagera, C., additional, Lebas, I., additional, Le Caer, H., additional, Maguire, C., additional, Mir, O., additional, Natur, S., additional, Ortholan, C., additional, Pigneux, A., additional, Prou, M., additional, Qabbal, R., additional, Rousseau, F., additional, Rouzier, R., additional, Roveri, A., additional, Sargos, P., additional, Servagi, S., additional, Servent, V., additional, Ysebaert, L., additional, Alibhai, S., additional, Balducci, L., additional, Bastiaannet, E., additional, Bron, D., additional, Cheng, K., additional, Cohen, H.J., additional, Cornelis, F., additional, De Glas, N., additional, Kalsi, T., additional, Kanesvaran, R., additional, Kenis, C., additional, Hamaker, M., additional, Holmes, H., additional, Hsu, T., additional, Lichtman, S., additional, Mohile, S., additional, O'Donovan, A., additional, Puts, M., additional, Repetto, L., additional, Singhal, N., additional, Steer, C., additional, Stolz Baskett, P., additional, Van De Water, W., additional, Van Leuven, B., additional, Wedding, U., additional, Wildes, T., additional, Wildiers, H., additional, and Zulian, G., additional

Published
2018
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27. Dose de tolérance à l’irradiation des tissus sains : le poumon

Author

Mornex F and Ortholan C

Subjects
medicine.medical_specialty, Lung, business.industry, Cumulative dose, Radiography, External beam radiation, Normal tissue, Pulmonary function testing, medicine.anatomical_structure, Oncology, Dose-Limiting, medicine, Radiology, Nuclear Medicine and imaging, Medical physics, Radiology, business, Complication
Abstract

Radiation pneumonitis is the most common dose limiting complication of thoracic radiation. Clinically significant radiation pneumonitis usually develops in 10-20% of patients. Characteristic clinical features associated with radiation pneumonitis include dyspnea, non-productive cough, radiographic opacification confined to the outlines of the field of radiation treatment and changes in pulmonary function measures. The risk of radiation pneumonitis is related to the cumulative dose of radiation to normal tissue and to patients and tumor features. Some studies demonstrated that preexisting pulmonary lung dysfunction, tumour location in lower lobes, use of concurrent chemotherapy could increase the risk of radiation pneumonitis. Controversies persist about which dosimetric parameter optimally predicts the risk of radiation pneumonitis. Mean lung dose, V20 and V30 are the most studied parameters. However, no ideal dosimetric parameter has been identified. The objective of this review is to summarize predictive factors of radiation pneumonitis, and to evaluate the predictive ability of various dose-volume histogram parameters for routine practice.

Published
2010

28. The ELAN-ONCOVAL (ELderly heAd and Neck cancer-Oncology eValuation) study: Evaluation of the feasibility of a suited geriatric assessment for use by oncologists to classify patients as fit or unfit

Author

Mertens, C., primary, Le Caer, H., additional, Ortholan, C., additional, Blot, E., additional, Even, C., additional, Rousselot, H., additional, Peyrade, F., additional, Sire, C., additional, Cupissol, D., additional, Pointreau, Y., additional, Debourdeau, P., additional, Rolland, F., additional, Fayette, J., additional, Capitain, O., additional, Sun, X., additional, Debbah, M., additional, Schwob, D., additional, Boulahssass, R., additional, Aupérin, A., additional, and Guigay, J., additional

Published
2017
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29. PO-147: The ELAN program: Customised treatment of SCCHN elderly patients according to geriatric assessment

Author

Guigay (France), J., primary, Ortholan, C., additional, Le Caer, H., additional, Renardoldrini, S., additional, Sun, X., additional, Mayache-badis, L., additional, Geoffrois, L., additional, Fayette, J., additional, Even, C., additional, Vansteene, D., additional, Pointreau, Y., additional, Schwob, D., additional, Vintonenko, N., additional, Michel, C., additional, Bourhis, J., additional, Auperin, A., additional, and Mertens, C., additional

Published
2017
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30. 1110O - Personalized treatment according to geriatric assessment in first-line recurrent and/or metastatic (R/M) head and neck squamous cell cancer (HNSCC) patients aged 70 or over: ELAN (ELderly heAd and Neck cancer) FIT and UNFIT trials

Author

Guigay, J., Auperin, A., Mertens, C., Even, C., Geoffrois, L., Cupissol, D., Rolland, F., Sire, C., Fayette, J., Peyrade, F., Blot, E., Debourdeau, P., Bozec, L., Capitain, O., Pointreau, Y., Brard, C., Michel, C., Schwob, D., Ortholan, C., and Le Caer, H.

Published
2019
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31. [Teeth and irradiation in head and neck cancer]

Author

Thariat, Juliette, De Mones, E., Darcourt, V., Poissonnet, G., Dassonville, O., Savoldelli, C., Marcy, P.-Y., Odin, G., Guevara, N., Bozec, A., Ortholan, C., Santini, J., Bensadoun, R.-J., Université Nice Sophia Antipolis (... - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA), Institute of Developmental Biology and Cancer (IBDC), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Centre National de la Recherche Scientifique (CNRS)-Université Côte d'Azur (UCA), Dept. of Oto-Rhino-Laryngology, and Centre Hospitalier Universitaire de Nice (CHU Nice)

Subjects
Adolescent, Dental Plaque, MESH: Radiation Injuries, Dental Caries, MESH: Dental Plaque, Young Adult, stomatognathic system, MESH: Child, MESH: Osteoradionecrosis, MESH: Dose-Response Relationship, Radiation, Humans, MESH: Hyperbaric Oxygenation, Tooth, Deciduous, Child, Dental Care, Radiation Injuries, MESH: Radiotherapy Dosage, [SDV.BDD]Life Sciences [q-bio]/Development Biology, MESH: Adolescent, Hyperbaric Oxygenation, MESH: Humans, MESH: Tooth, Dose-Response Relationship, Radiation, Radiotherapy Dosage, MESH: Dental Caries, MESH: Tooth, Deciduous, MESH: Head and Neck Neoplasms, stomatognathic diseases, Osteoradionecrosis, Head and Neck Neoplasms, MESH: Young Adult, MESH: Dental Care, Tooth
Abstract

International audience; Pre-irradiation dental care depends on teeth health, fields and dose of irradiation, compliance to fluorides, cessation of tobacco and psychosocial cofactors. Dental care aims at preventing complications and preserving the quality of life (eating, speech and aesthetics). Approximately 11% of patients do not require any pre-irradiation dental care. Dental complications vary from slight colorations of the teeth to major complication such as osteoradionecrosis. Osteoradionecrosis rates vary from 1 to 9%, and may be decreased by using a 21-day delay between extractions and irradiation, provided that it does not postpone cancer treatment, with a dose-dependent risk ( or =20% if >60 Gy). Osteoradionecrosis occurs spontaneously (35%), mostly involves the mandibula (85%).

Published
2010

32. Place de l’arcthérapie modulée et de la chimiothérapie concomitante dans la prise en charge des cancers du canal anal localement évolués

Author

Troussier, I., primary, Huguet, F., additional, Servagi-Vernat, S., additional, Benahim, C., additional, Khalifa, J., additional, Darmon, I., additional, Ortholan, C., additional, Krebs, L., additional, Dejean, C., additional, Fenoglietto, P., additional, Vieillot, S., additional, Bensadoun, R.-J., additional, and Thariat, J., additional

Published
2015
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35. 1050PD - The ELAN-ONCOVAL (ELderly heAd and Neck cancer-Oncology eValuation) study: Evaluation of the feasibility of a suited geriatric assessment for use by oncologists to classify patients as fit or unfit

Author

Mertens, C., Le Caer, H., Ortholan, C., Blot, E., Even, C., Rousselot, H., Peyrade, F., Sire, C., Cupissol, D., Pointreau, Y., Debourdeau, P., Rolland, F., Fayette, J., Capitain, O., Sun, X., Debbah, M., Schwob, D., Boulahssass, R., Aupérin, A., and Guigay, J.

Published
2017
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46. Xérostomie tardive après radiothérapie conformationnelle avec modulation d’intensité des cancers des voies aérodigestives supérieures : étude 2004-03 du Groupe oncologie et radiothérapie de la tête et du cou (Gortec)

Author

Toledano, I., primary, Graff, P., additional, Serre, A., additional, Bensadoun, R.-J., additional, Ortholan, C., additional, Calais, G., additional, Alfonsi, M., additional, Giraud, P., additional, Racadot, S., additional, and Lapeyre, M., additional

Published
2010
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47. Éditorial

Author

Gérard, J.-P., primary, Ortholan, C., additional, and Pointreau, Y., additional

Published
2010
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