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7. Scientific integrity issues in Environmental Toxicology and Chemistry: Improving research reproducibility, credibility, and transparency

Author

Mebane, Christopher A, primary, Sumpter, John P, additional, Fairbrother, Anne, additional, Augspurger, Thomas P, additional, Canfield, Timothy J, additional, Goodfellow, William L, additional, Guiney, Patrick D, additional, LeHuray, Anne, additional, Maltby, Lorraine, additional, Mayfield, David B, additional, McLaughlin, Michael J, additional, Ortego, Lisa S, additional, Schlekat, Tamar, additional, Scroggins, Richard P, additional, and Verslycke, Tim A, additional

Published
2019
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8. Relevance Weighting of Tier 1 Endocrine Screening Endpoints by Rank Order

Author

Borgert, Christopher J., primary, Stuchal, Leah D., additional, Mihaich, Ellen M., additional, Becker, Richard A., additional, Bentley, Karin S., additional, Brausch, John M., additional, Coady, Katie, additional, Geter, David R., additional, Gordon, Elliot, additional, Guiney, Patrick D., additional, Hess, Frederick, additional, Holmes, Catherine M., additional, LeBaron, Matthew J., additional, Levine, Steve, additional, Marty, Sue, additional, Mukhi, Sandeep, additional, Neal, Barbara H., additional, Ortego, Lisa S., additional, Saltmiras, David A., additional, Snajdr, Suzanne, additional, Staveley, Jane, additional, and Tobia, Abraham, additional

Published
2014
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11. Lessons Learned, Challenges, and Opportunities: The U.S. Endocrine Disruptor Screening Program.

Author

Juberg, Daland R., Borghoff, Susan J., Becker, Richard A., Casey, Warren, Hartung, Thomas, Holsapple, Michael P., Sue Marty, M., Mihaich, Ellen M., Van Der Kraak, Glen, Wade, Michael G., Willett, Catherine E., Andersen, Melvin E., Borgert, Christopher J., Coady, Katherine K., Dourson, Michael L., Fowle III, John R., Gray, L. Earl, Lamb, James C., Ortego, Lisa S., and Schug, Thaddeus T.

Abstract

In 1996, the U.S. Congress passed the Food Quality Protection Act and amended the Safe Drinking Water Act (SDWA) requiring the U.S. Environmental Protection Agency (EPA) to implement a screening program to investigate the potential of pesticide chemicals and drinking water contaminants to adversely affect endocrine pathways. Consequently, the EPA launched the Endocrine Disruptor Screening Program (EDSP) to develop and validate estrogen, androgen, and thyroid (EAT) pathway screening assays and to produce standardized and harmonized test guidelines for regulatory application. In 2009, the EPA issued the first set of test orders for EDSP screening and a total of 50 pesticide actives and 2 inert ingredients have been evaluated using the battery of EDSP Tier 1 screening assays (i.e., five in vitro assays and six in vivo assays). To provide a framework for retrospective analysis of the data generated and to collect the insight of multiple stakeholders involved in the testing, more than 240 scientists from government, industry, academia, and non-profit organizations recently participated in a workshop titled "Lessons Learned, Challenges, and Opportunities: The U.S. Endocrine Disruptor Screening Program." The workshop focused on the science and experience to date and was organized into three focal sessions: (a) Performance of the EDSP Tier 1 Screening Assays for Estrogen, Androgen, and Thyroid Pathways; (b) Practical Applications of Tier 1 Data; and (c) Indications and Opportunities for Future Endocrine Testing. A number of key findings and recommendations related to future EDSP evaluations emanated from the collective sessions. [ABSTRACT FROM AUTHOR]

Published
2014
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