1. Regulation of endothelial cell function BY FAK and PYK2
- Author
-
Joanne E. Murphy-Ullrich and Orr Aw
- Subjects
Endothelium ,Chemistry ,Neovascularization, Physiologic ,Vascular permeability ,Focal Adhesion Kinase 2 ,Protein-Tyrosine Kinases ,Mechanotransduction, Cellular ,Cell biology ,Vascular endothelial growth factor B ,Endothelial stem cell ,Capillary Permeability ,Vascular endothelial growth factor A ,Mice ,Vasculogenesis ,medicine.anatomical_structure ,Vascular endothelial growth factor C ,Cell Movement ,Focal Adhesion Kinase 1 ,Focal Adhesion Protein-Tyrosine Kinases ,medicine ,Animals ,Humans ,Endothelium, Vascular - Abstract
Endothelial cells form a continuous single layer lining throughout the vascular tree. Such positioning allows the endothelium to monitor numerous environmental signals within the blood vessel, including blood composition, structural matrix, and blood flow dynamics. Following signal integration, endothelial cells then induce context-specific changes in vessel properties. The nonreceptor tyrosine kinases focal adhesion kinase (FAK) and proline-rich tyrosine kinase-2 (Pyk2) are activated by integrins, growth factors, and mechanical stimuli, suggesting a potentially important role in the integration of environmental stimuli. This review will explore the current understanding of FAK and Pyk2 signaling in endothelial regulation of vascular function.
- Published
- 2004