Search

Your search keyword '"Orntoft, Torben F."' showing total 288 results
Start Over Author "Orntoft, Torben F."
288 results on '"Orntoft, Torben F."'

2. Prognostic Impact of a 12-gene Progression Score in Non–muscle-invasive Bladder Cancer: A Prospective Multicentre Validation Study

Author

Dyrskjøt, Lars, Reinert, Thomas, Algaba, Ferran, Christensen, Emil, Nieboer, Daan, Hermann, Gregers G., Mogensen, Karin, Beukers, Willemien, Marquez, Mirari, Segersten, Ulrika, Høyer, Søren, Ulhøi, Benedicte P., Hartmann, Arndt, Stöhr, Robert, Wach, Sven, Nawroth, Roman, Schwamborn, Kristina, Tulic, Cane, Simic, Tatjana, Junker, Kerstin, Harving, Niels, Petersen, Astrid C., Jensen, Jørgen B., Keck, Bastian, Grimm, Marc-Oliver, Horstmann, Marcus, Maurer, Tobias, Steyerberg, Ewout W., Zwarthoff, Ellen C., Real, Francisco X., Malats, Núria, Malmström, Per-Uno, and Ørntoft, Torben F.

Published
2017
Full Text
View/download PDF

7. SNHG16 is regulated by the Wnt pathway in colorectal cancer and affects genes involved in lipid metabolism

Author

Christensen, Lise Lotte, True, Kirsten, Hamilton, Mark P., Nielsen, Morten M., Damas, Nkerorema D., Damgaard, Christian K., Ongen, Halit, Dermitzakis, Emmanouil, Bramsen, Jesper B., Pedersen, Jakob S., Lund, Anders H., Vang, Søren, Stribolt, Katrine, Madsen, Mogens R., Laurberg, Søren, McGuire, Sean E., Ørntoft, Torben F., and Andersen, Claus L.

Published
2016
Full Text
View/download PDF

10. Data from Risk Analysis of Prostate Cancer in PRACTICAL, a Multinational Consortium, Using 25 Known Prostate Cancer Susceptibility Loci

Author

Amin Al Olama, Ali, primary, Benlloch, Sara, primary, Antoniou, Antonis C., primary, Giles, Graham G., primary, Severi, Gianluca, primary, Neal, David E., primary, Hamdy, Freddie C., primary, Donovan, Jenny L., primary, Muir, Kenneth, primary, Schleutker, Johanna, primary, Henderson, Brian E., primary, Haiman, Christopher A., primary, Schumacher, Fredrick R., primary, Pashayan, Nora, primary, Pharoah, Paul D.P., primary, Ostrander, Elaine A., primary, Stanford, Janet L., primary, Batra, Jyotsna, primary, Clements, Judith A., primary, Chambers, Suzanne K., primary, Weischer, Maren, primary, Nordestgaard, Børge G., primary, Ingles, Sue A., primary, Sorensen, Karina D., primary, Orntoft, Torben F., primary, Park, Jong Y., primary, Cybulski, Cezary, primary, Maier, Christiane, primary, Doerk, Thilo, primary, Dickinson, Joanne L., primary, Cannon-Albright, Lisa, primary, Brenner, Hermann, primary, Rebbeck, Timothy R., primary, Zeigler-Johnson, Charnita, primary, Habuchi, Tomonori, primary, Thibodeau, Stephen N., primary, Cooney, Kathleen A., primary, Chappuis, Pierre O., primary, Hutter, Pierre, primary, Kaneva, Radka P., primary, Foulkes, William D., primary, Zeegers, Maurice P., primary, Lu, Yong-Jie, primary, Zhang, Hong-Wei, primary, Stephenson, Robert, primary, Cox, Angela, primary, Southey, Melissa C., primary, Spurdle, Amanda B., primary, FitzGerald, Liesel, primary, Leongamornlert, Daniel, primary, Saunders, Edward, primary, Tymrakiewicz, Malgorzata, primary, Guy, Michelle, primary, Dadaev, Tokhir, primary, Little, Sarah J., primary, Govindasami, Koveela, primary, Sawyer, Emma, primary, Wilkinson, Rosemary, primary, Herkommer, Kathleen, primary, Hopper, John L., primary, Lophatonanon, Aritaya, primary, Rinckleb, Antje E., primary, Kote-Jarai, Zsofia, primary, Eeles, Rosalind A., primary, and Easton, Douglas F., primary

Published
2023
Full Text
View/download PDF

15. Supplementary Figure 1 from Risk Analysis of Prostate Cancer in PRACTICAL, a Multinational Consortium, Using 25 Known Prostate Cancer Susceptibility Loci

Author

Amin Al Olama, Ali, primary, Benlloch, Sara, primary, Antoniou, Antonis C., primary, Giles, Graham G., primary, Severi, Gianluca, primary, Neal, David E., primary, Hamdy, Freddie C., primary, Donovan, Jenny L., primary, Muir, Kenneth, primary, Schleutker, Johanna, primary, Henderson, Brian E., primary, Haiman, Christopher A., primary, Schumacher, Fredrick R., primary, Pashayan, Nora, primary, Pharoah, Paul D.P., primary, Ostrander, Elaine A., primary, Stanford, Janet L., primary, Batra, Jyotsna, primary, Clements, Judith A., primary, Chambers, Suzanne K., primary, Weischer, Maren, primary, Nordestgaard, Børge G., primary, Ingles, Sue A., primary, Sorensen, Karina D., primary, Orntoft, Torben F., primary, Park, Jong Y., primary, Cybulski, Cezary, primary, Maier, Christiane, primary, Doerk, Thilo, primary, Dickinson, Joanne L., primary, Cannon-Albright, Lisa, primary, Brenner, Hermann, primary, Rebbeck, Timothy R., primary, Zeigler-Johnson, Charnita, primary, Habuchi, Tomonori, primary, Thibodeau, Stephen N., primary, Cooney, Kathleen A., primary, Chappuis, Pierre O., primary, Hutter, Pierre, primary, Kaneva, Radka P., primary, Foulkes, William D., primary, Zeegers, Maurice P., primary, Lu, Yong-Jie, primary, Zhang, Hong-Wei, primary, Stephenson, Robert, primary, Cox, Angela, primary, Southey, Melissa C., primary, Spurdle, Amanda B., primary, FitzGerald, Liesel, primary, Leongamornlert, Daniel, primary, Saunders, Edward, primary, Tymrakiewicz, Malgorzata, primary, Guy, Michelle, primary, Dadaev, Tokhir, primary, Little, Sarah J., primary, Govindasami, Koveela, primary, Sawyer, Emma, primary, Wilkinson, Rosemary, primary, Herkommer, Kathleen, primary, Hopper, John L., primary, Lophatonanon, Aritaya, primary, Rinckleb, Antje E., primary, Kote-Jarai, Zsofia, primary, Eeles, Rosalind A., primary, and Easton, Douglas F., primary

Published
2023
Full Text
View/download PDF

16. Supplementary Tables 1-8 from Risk Analysis of Prostate Cancer in PRACTICAL, a Multinational Consortium, Using 25 Known Prostate Cancer Susceptibility Loci

Author

Amin Al Olama, Ali, primary, Benlloch, Sara, primary, Antoniou, Antonis C., primary, Giles, Graham G., primary, Severi, Gianluca, primary, Neal, David E., primary, Hamdy, Freddie C., primary, Donovan, Jenny L., primary, Muir, Kenneth, primary, Schleutker, Johanna, primary, Henderson, Brian E., primary, Haiman, Christopher A., primary, Schumacher, Fredrick R., primary, Pashayan, Nora, primary, Pharoah, Paul D.P., primary, Ostrander, Elaine A., primary, Stanford, Janet L., primary, Batra, Jyotsna, primary, Clements, Judith A., primary, Chambers, Suzanne K., primary, Weischer, Maren, primary, Nordestgaard, Børge G., primary, Ingles, Sue A., primary, Sorensen, Karina D., primary, Orntoft, Torben F., primary, Park, Jong Y., primary, Cybulski, Cezary, primary, Maier, Christiane, primary, Doerk, Thilo, primary, Dickinson, Joanne L., primary, Cannon-Albright, Lisa, primary, Brenner, Hermann, primary, Rebbeck, Timothy R., primary, Zeigler-Johnson, Charnita, primary, Habuchi, Tomonori, primary, Thibodeau, Stephen N., primary, Cooney, Kathleen A., primary, Chappuis, Pierre O., primary, Hutter, Pierre, primary, Kaneva, Radka P., primary, Foulkes, William D., primary, Zeegers, Maurice P., primary, Lu, Yong-Jie, primary, Zhang, Hong-Wei, primary, Stephenson, Robert, primary, Cox, Angela, primary, Southey, Melissa C., primary, Spurdle, Amanda B., primary, FitzGerald, Liesel, primary, Leongamornlert, Daniel, primary, Saunders, Edward, primary, Tymrakiewicz, Malgorzata, primary, Guy, Michelle, primary, Dadaev, Tokhir, primary, Little, Sarah J., primary, Govindasami, Koveela, primary, Sawyer, Emma, primary, Wilkinson, Rosemary, primary, Herkommer, Kathleen, primary, Hopper, John L., primary, Lophatonanon, Aritaya, primary, Rinckleb, Antje E., primary, Kote-Jarai, Zsofia, primary, Eeles, Rosalind A., primary, and Easton, Douglas F., primary

Published
2023
Full Text
View/download PDF

20. Supplementary Notes from Risk Analysis of Prostate Cancer in PRACTICAL, a Multinational Consortium, Using 25 Known Prostate Cancer Susceptibility Loci

Author

Amin Al Olama, Ali, primary, Benlloch, Sara, primary, Antoniou, Antonis C., primary, Giles, Graham G., primary, Severi, Gianluca, primary, Neal, David E., primary, Hamdy, Freddie C., primary, Donovan, Jenny L., primary, Muir, Kenneth, primary, Schleutker, Johanna, primary, Henderson, Brian E., primary, Haiman, Christopher A., primary, Schumacher, Fredrick R., primary, Pashayan, Nora, primary, Pharoah, Paul D.P., primary, Ostrander, Elaine A., primary, Stanford, Janet L., primary, Batra, Jyotsna, primary, Clements, Judith A., primary, Chambers, Suzanne K., primary, Weischer, Maren, primary, Nordestgaard, Børge G., primary, Ingles, Sue A., primary, Sorensen, Karina D., primary, Orntoft, Torben F., primary, Park, Jong Y., primary, Cybulski, Cezary, primary, Maier, Christiane, primary, Doerk, Thilo, primary, Dickinson, Joanne L., primary, Cannon-Albright, Lisa, primary, Brenner, Hermann, primary, Rebbeck, Timothy R., primary, Zeigler-Johnson, Charnita, primary, Habuchi, Tomonori, primary, Thibodeau, Stephen N., primary, Cooney, Kathleen A., primary, Chappuis, Pierre O., primary, Hutter, Pierre, primary, Kaneva, Radka P., primary, Foulkes, William D., primary, Zeegers, Maurice P., primary, Lu, Yong-Jie, primary, Zhang, Hong-Wei, primary, Stephenson, Robert, primary, Cox, Angela, primary, Southey, Melissa C., primary, Spurdle, Amanda B., primary, FitzGerald, Liesel, primary, Leongamornlert, Daniel, primary, Saunders, Edward, primary, Tymrakiewicz, Malgorzata, primary, Guy, Michelle, primary, Dadaev, Tokhir, primary, Little, Sarah J., primary, Govindasami, Koveela, primary, Sawyer, Emma, primary, Wilkinson, Rosemary, primary, Herkommer, Kathleen, primary, Hopper, John L., primary, Lophatonanon, Aritaya, primary, Rinckleb, Antje E., primary, Kote-Jarai, Zsofia, primary, Eeles, Rosalind A., primary, and Easton, Douglas F., primary

Published
2023
Full Text
View/download PDF

21. Supplementary Figure 3 from Risk Analysis of Prostate Cancer in PRACTICAL, a Multinational Consortium, Using 25 Known Prostate Cancer Susceptibility Loci

Author

Amin Al Olama, Ali, primary, Benlloch, Sara, primary, Antoniou, Antonis C., primary, Giles, Graham G., primary, Severi, Gianluca, primary, Neal, David E., primary, Hamdy, Freddie C., primary, Donovan, Jenny L., primary, Muir, Kenneth, primary, Schleutker, Johanna, primary, Henderson, Brian E., primary, Haiman, Christopher A., primary, Schumacher, Fredrick R., primary, Pashayan, Nora, primary, Pharoah, Paul D.P., primary, Ostrander, Elaine A., primary, Stanford, Janet L., primary, Batra, Jyotsna, primary, Clements, Judith A., primary, Chambers, Suzanne K., primary, Weischer, Maren, primary, Nordestgaard, Børge G., primary, Ingles, Sue A., primary, Sorensen, Karina D., primary, Orntoft, Torben F., primary, Park, Jong Y., primary, Cybulski, Cezary, primary, Maier, Christiane, primary, Doerk, Thilo, primary, Dickinson, Joanne L., primary, Cannon-Albright, Lisa, primary, Brenner, Hermann, primary, Rebbeck, Timothy R., primary, Zeigler-Johnson, Charnita, primary, Habuchi, Tomonori, primary, Thibodeau, Stephen N., primary, Cooney, Kathleen A., primary, Chappuis, Pierre O., primary, Hutter, Pierre, primary, Kaneva, Radka P., primary, Foulkes, William D., primary, Zeegers, Maurice P., primary, Lu, Yong-Jie, primary, Zhang, Hong-Wei, primary, Stephenson, Robert, primary, Cox, Angela, primary, Southey, Melissa C., primary, Spurdle, Amanda B., primary, FitzGerald, Liesel, primary, Leongamornlert, Daniel, primary, Saunders, Edward, primary, Tymrakiewicz, Malgorzata, primary, Guy, Michelle, primary, Dadaev, Tokhir, primary, Little, Sarah J., primary, Govindasami, Koveela, primary, Sawyer, Emma, primary, Wilkinson, Rosemary, primary, Herkommer, Kathleen, primary, Hopper, John L., primary, Lophatonanon, Aritaya, primary, Rinckleb, Antje E., primary, Kote-Jarai, Zsofia, primary, Eeles, Rosalind A., primary, and Easton, Douglas F., primary

Published
2023
Full Text
View/download PDF

23. Supplementary Figure 2 from Risk Analysis of Prostate Cancer in PRACTICAL, a Multinational Consortium, Using 25 Known Prostate Cancer Susceptibility Loci

Author

Amin Al Olama, Ali, primary, Benlloch, Sara, primary, Antoniou, Antonis C., primary, Giles, Graham G., primary, Severi, Gianluca, primary, Neal, David E., primary, Hamdy, Freddie C., primary, Donovan, Jenny L., primary, Muir, Kenneth, primary, Schleutker, Johanna, primary, Henderson, Brian E., primary, Haiman, Christopher A., primary, Schumacher, Fredrick R., primary, Pashayan, Nora, primary, Pharoah, Paul D.P., primary, Ostrander, Elaine A., primary, Stanford, Janet L., primary, Batra, Jyotsna, primary, Clements, Judith A., primary, Chambers, Suzanne K., primary, Weischer, Maren, primary, Nordestgaard, Børge G., primary, Ingles, Sue A., primary, Sorensen, Karina D., primary, Orntoft, Torben F., primary, Park, Jong Y., primary, Cybulski, Cezary, primary, Maier, Christiane, primary, Doerk, Thilo, primary, Dickinson, Joanne L., primary, Cannon-Albright, Lisa, primary, Brenner, Hermann, primary, Rebbeck, Timothy R., primary, Zeigler-Johnson, Charnita, primary, Habuchi, Tomonori, primary, Thibodeau, Stephen N., primary, Cooney, Kathleen A., primary, Chappuis, Pierre O., primary, Hutter, Pierre, primary, Kaneva, Radka P., primary, Foulkes, William D., primary, Zeegers, Maurice P., primary, Lu, Yong-Jie, primary, Zhang, Hong-Wei, primary, Stephenson, Robert, primary, Cox, Angela, primary, Southey, Melissa C., primary, Spurdle, Amanda B., primary, FitzGerald, Liesel, primary, Leongamornlert, Daniel, primary, Saunders, Edward, primary, Tymrakiewicz, Malgorzata, primary, Guy, Michelle, primary, Dadaev, Tokhir, primary, Little, Sarah J., primary, Govindasami, Koveela, primary, Sawyer, Emma, primary, Wilkinson, Rosemary, primary, Herkommer, Kathleen, primary, Hopper, John L., primary, Lophatonanon, Aritaya, primary, Rinckleb, Antje E., primary, Kote-Jarai, Zsofia, primary, Eeles, Rosalind A., primary, and Easton, Douglas F., primary

Published
2023
Full Text
View/download PDF

36. Putative cis-regulatory drivers in colorectal cancer

Author

Ongen, Halit, Andersen, Claus L., Bramsen, Jesper B., Oster, Bodil, Rasmussen, Mads H., Ferreira, Pedro G., Sandoval, Juan, Vidal, Enrique, Whiffin, Nicola, Planchon, Alexandra, Padioleau, Ismael, Bielser, Deborah, Romano, Luciana, Tomlinson, Ian, Houlston, Richard S., Esteller, Manel, Orntoft, Torben F., and Dermitzakis, Emmanouil T.

Subjects
Oncology, Experimental, Gene expression -- Research, Genetic research, Quantitative trait loci -- Identification and classification, Colorectal cancer -- Development and progression -- Genetic aspects, Cancer -- Research, Environmental issues, Science and technology, Zoology and wildlife conservation
Abstract

The cis-regulatory effects responsible for cancer development have not been as extensively studied as the perturbations of the protein coding genome in tumorigenesis (1,2). To better characterize colorectal cancer (CRC) development we conducted an RNA-sequencing experiment of 103 matched tumour and normal colon mucosa samples from Danish CRC patients, 90 of which were germline-genotyped. By investigating allele-specific expression (ASE) we show that the germline genotypes remain important determinants of allelic gene expression in tumours. Using the changes in ASE in matched pairs of samples we discover 71 genes with excess of somatic cis-regulatory effects in CRC, suggesting a cancer driver role. We correlate genotypes and gene expression to identify expression quantitative trait loci (eQTLs) and find 1,693 and 948 eQTLs in normal samples and tumours, respectively. We estimate that 36% of the tumour eQTLs are exclusive to CRC and show that this specificity is partially driven by increased expression of specific transcription factors and changes in methylation patterns. We show that tumour-specific eQTLs are more enriched for low CRC genome-wide association study (GWAS) P values than shared eQTLs, which suggests that some of the GWAS variants are tumour specific regulatory variants. Importantly, tumour-specific eQTL genes also accumulate more somatic mutations when compared to the shared eQTL genes, raising the possibility that they constitute germline-derived cancer regulatory drivers. Collectively the integration of genome and the transcriptome reveals a substantial number of putative somatic and germline cis-regulatory cancer changes that may have a role in tumorigenesis., The non-coding genome has so far been overlooked in the search for drivers in cancer, except for some isolated examples (1,2). The genome contains regulatory non-coding germline variation affecting gene [...]

Published
2014

42. Multiple colorectal adenomas, classic adenomatous polyposis, and germ-line mutations in MYH

Author

Sieber, Oliver M., Lipton, Lara, Crabtree, Michael, Heinimann, Karl, Fidalgo, Paulo, Phillips, Robin K.S., Bisgaard, Marie-Luise, Orntoft, Torben F., Aaltonen, Lauri A., Hodgson, Shirley V., Thomas, Huw J.W., and Tomlinson, Ian P.M.

Subjects
Colorectal cancer -- Genetic aspects
Abstract

Mutations in the MYH gene can cause colorectal cancer, according to a study of 259 patients. This gene codes for an enzyme that repairs DNA. If patients with colorectal cancer do not have a mutation in the APC gene, they should be tested for MYH mutations.

Published
2003

44. Cytokines interleukin-1β and tumor necrosis factor-α regulate different transcriptional and alternative splicing networks in primary β-cells

Author

Ortis, Fernanda, Naamane, Najib, Flamez, Daisy, Ladriere, Laurence, Moore, Fabrice, Cunha, Daniel A., Colli, Maikel L., Thykjaer, Thomas, Thorsen, Kasper, Orntoft, Torben F., and Eizirik, Decio L.

Subjects
Cytokines -- Research, RNA splicing -- Physiological aspects -- Research, Tumor necrosis factor -- Research, Health
Abstract

OBJECTIVE--Cytokines contribute to pancreatic β-cell death in type 1 diabetes. This effect is mediated by complex gene networks that remain to be characterized. We presently utilized array analysis to define the global expression pattern of genes, including spliced variants, modified by the cytokines interleukin (IL)-1β + interferon (IFN)-γ and tumor necrosis factor (TNF)-α + IFN-γ in primary rat β-cells. RESEARCH DESIGN AND METHODS--Fluorescence-activated cell sorter-purified rat p-cells were exposed to IL-1β + IFN-γ or TNF-α + IFN-γ for 6 or 24 h, and global gene expression was analyzed by microarray. Key results were confirmed by RT-PCR, and small-interfering RNAs were used to investigate the mechanistic role of novel and relevant transcription factors identified by pathway analysis. RESULTS--Nearly 16,000 transcripts were detected as present in β-cells, with temporal differences in the number of genes modulated by IL-1β + IFNγ/or TNF-α + IFN-γ. These cytokine combinations induced differential expression of inflammatory response genes, which is related to differential induction of IFN regulatory factor-7. Both treatments decreased the expression of genes involved in the maintenance of β-cell phenotype and growth/regeneration. Cytokines induced hypoxia-inducible factor-α, which in this context has a proapoptotic role. Cytokines also modified the expression of >20 genes involved in RNA splicing, and exon array analysis showed cytokine-induced changes in alternative splicing of >50% of the cytokine-modified genes. CONCLUSIONS--The present study doubles the number of known genes expressed in primary β-cells, modified or not by cytokines, and indicates the biological role for several novel cytokine-modified pathways in β-cells. It also shows that cytokines modify alternative splicing in β-cells, opening a new avenue of research for the field. Diabetes 59:358-374, 2010, Type 1 diabetes is an autoimmune disease characterized by a progressive and selective destruction of the pancreatic β-cells. During insulitis, activated macrophages and T-cells release cytokines such as interleukin (IL)-1β, [...]

Published
2010
Full Text
View/download PDF

49. Antibody-based screening for hereditary nonpolyposis colorectal carcinoma compared with microsatellite analysis and sequencing

Author

Christensen, Mariann, Katballe, Niels, Wikman, Friedrik, Primdahl, Hanne, Sorensen, Flemming B., Laurberg, Soren, and Orntoft, Torben F.

Subjects
Oncology, Experimental -- Comparative analysis, Cancer patients -- Health aspects, Cancer patients -- Care and treatment, Colorectal cancer -- Health aspects, Colorectal cancer -- Care and treatment, Viral antibodies -- Genetic aspects, Antibodies, Health
Published
2002

Catalog

Books, media, physical & digital resources
See catalog results