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176 results on '"Ormezzano, Olivier"'

1. Catheter-based renal denervation in the treatment of arterial hypertension: An expert consensus statement on behalf of the French Society of Hypertension (SFHTA), French Society of Radiology (SFR), French Society of Interventional Cardiology (GACI), French Society of Cardiology (SFC), French Association of Private Cardiologists (CNCF), French Association of Hospital Cardiologists (CNCH), French Society of Thoracic and Cardiovascular Surgery (SFCTCV) and French Society of Vascular and Endovascular Surgery (SCVE)

Author

Pathak, Atul, Boulestreau, Romain, Sapoval, Marc, Lantelme, Pierre, Duly-Bouhanick, Beatrice, Benamer, Hakim, Bejan-Angoulvant, Theodora, Cremer, Antoine, Amar, Laurence, Delarche, Nicolas, Ormezzano, Olivier, Sabouret, Pierre, Silhol, François, Sosner, Philippe, Lopez-Sublet, Marilucy, Cohen, Ariel, Courand, Pierre Yves, and Azizi, Michel

Published
2024
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2. Dual endothelin antagonist aprocitentan for resistant hypertension (PRECISION): a multicentre, blinded, randomised, parallel-group, phase 3 trial

Author

Reid, Christopher, Schlaich, Markus, Katz, Ivor, Ajani, Andrew, Biswas, Sinjini, Esler, Murray, Elder, Grahame, Roger, Simon, Colquhoun, David, Mooney, John, De Backer, Tine, Persu, Alexandre, Chaumont, Martin, Krzesinski, Jean-Marie, Vanassche, Thomas, Girard, Ginette, Pliamm, Lew, Schiffrin, Ernesto, Merali, Fatima, Dresser, George, Vallee, Michel, Jolly, Shivinder, Chow, Stephen, Wang, Jiguang, Mu, Jianjun, Yu, Jing, Yuan, Hong, Feng, Yingqing, Zhang, Xin, Xie, Jianhong, Lin, Ling, Soucek, Miroslav, Widimsky, Jiri, Cifkova, Renata, Vaclavik, Jan, Ullrych, Martin, Lukac, Martin, Rychlik, Ivan, Guldager Lauridsen, Thomas, Kantola, Ilkka, Taurio, Jyrki, Ukkola, Olavi, Ormezzano, Olivier, Gosse, Philippe, Azizi, Michel, Courand, Pierre-Yves, Delsart, Pascal, Tartiere, Jean Michel, Mahfoud, Felix, Schmieder, Roland, Stegbauer, Johannes, Lurz, Philipp, Koziolek, Michael, Ott, Christian, Toursarkissian, Nicole, Tsioufis, Konstantinos, Kyfnidis, Konstantinos, Manolis, Athanasios, Patsilinakos, Sotirios, Zebekakis, Pantelis, Karavidas, Apostolos, Denes, Pall, Bezzegh, Katalin, Zsom, Marianna, Kovacs, Laszlo, Sharabi, Yehonatan, Elias, Mazen, Sukholutsky, Ivetta, Yosefy, Chaim, Kenis, Irina, Atar, Shaul, Volpe, Massimo, Maria Lorenza, Muiesan, Taddei, Stefano, Grassi, Guido, Veglio, Franco, Son, Jung Woo, Kim, Jang-Young, Park, Joong-Il, Lee, Chang Hoon, Lee, Hae-Young, Raugaliene, Rasa, Marcinkeviciene, Jolanta Elena, Kavaliauskiene, Roma, Deinum, Jaap, Kroon, Abraham, van den Born, Bert-Jan, Januszewicz, Andrzej, Tykarski, Andrzej, Walczewska, Jolanta, Gaciong, Zbigniew, Wiecek, Andrzej, Chrostowska, Marzena, Kleinrok, Andrzej, Krekora, Jan, Kania, Grzegorz, Podrazka-Szczepaniak, Anna, Golawski, Cezary, Podziewski, Maciej, Kaczmarek, Barbara, Skoczylas, Grzegorz, Wilkolaski, Andrzej, Wozniak, Iwona, Janik-Palazzolo, Marzena, Rewerska, Barbara, Konradi, Aleksandra, Shvarts, Yuriy, Pecherina, Tamara, Nikolaev, Konstantin, Liudmila, Gapon, Orlikova, Olga, Mordovin, Viktor, Petrochenkova, Natalia, Kamalov, Gadel, Kosmacheva, Elena, Tyrenko, Vadim, Gorbunov, Vladimir, Obrezan, Andrey, Supryadkina, Tatiana, Ler, Irina, Kotenko, Oleg, Kuzin, Anatoly, Martínez García, Fernando, Redon, Josep, Oliveras, Anna, Beltran Romero, Luis, Shatylo, Valerii, Rudenko, Leonid, Bazylevych, Andriy, Rudyk, Yurii, Karpenko, Oleksandr, Stanislavchuk, Mykola, Tseluyko, Vira, Kushnir, Mykola, Asanov, Ervin, Sirenko, Yuriy, Yagensky, Andriy, Collier, David, Gupta, Pankaj, Webb, David, MacLeod, Mary, McLay, James, Peace, Aaron, Arora, Samir, Buchanan, Patricia, Harris, Robert, Degarmo, Ronald, Guillen, Mario, Karns, Adam, Neutel, Joel, Paliwal, Yogesh, Pettis, Karlton, Toth, Phillip D., Wayne, Jeffrey M., Butcher, Michael Bain, Diller, Phillip M., Oparil, Suzanne, Calhoun, David, Brautigam, Donald, Flack, John, Goldman, Jesse M., Rashidi, Arash, Aslam, Nabeel, Haley, William, Andrawis, Nabil, Lang, Brian, Miller, Randy, Powell, James, Dewhurst, Robert, Pritchard, James, Khanna, Dinesh, Tang, Dennis, Gabra, Nashwa, Park, Jean, Jones, Conigliaro, Scott, Cranford, Luna, Blanca, Mussaji, Murtaza, Bhagwat, Ravi, Bauer, Michael, McGinty, John, Nambiar, Rajesh, Sangrigoli, Renee, Davis, William Ross, Eaves, William, McGrew, Frank, Awad, Ahmed, Bolster, Eric, Scott, David, Kalirao, Paramjit, Dabel, Pascal, Calhoun, Wesley, Gouge, Steven, Warren, Mark, Lawrence, Mary Katherine, Jamal, Aamir, El-Shahawy, Mohamed, Mercado, Carlos, Kumar, Jayant, Velasquez-Mieyer, Pedro, Busch, Robert, Lewis, Todd, Rich, Lisa, Schlaich, Markus P, Bellet, Marc, Weber, Michael A, Danaietash, Parisa, Bakris, George L, Flack, John M, Dreier, Roland F, Sassi-Sayadi, Mouna, Haskell, Lloyd P, Narkiewicz, Krzysztof, and Wang, Ji-Guang

Published
2022
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4. Fractional Flow Reserve to Guide Treatment of Patients With Multivessel Coronary Artery Disease

Author

Leborgne, Laurent, Fournier, Alexandre, Jarry, Geneviève, Leleu, François, Malaquin, Dorothée, Mirode, Anfani, Belle, Loïc, Mangin, Lionel, Noirclerc, Nathalie, Barnay, Pierre, Hirsch, Jean-Lou, Metge, Marc, Pansiery, Michel, Soto, FrançoisXavier, Boge, Antoine, HadjHamou, Kamel, Miliani, Ichem, Molins, Guillaume, Mourot, Stéphane, Pelletier, Marion, Ressencourt, Olivier, Schaad, Frédéric, Coste, Pierre, Chasseriaud, Warren, Cetran, Laura, Poustis, Pierre, Morelle, Jean-Francois, Albert, Franck, Demicheli, Thibaud, Range, Grégroire, Thuaire, Christophe, Motreff, Pascal, Barber-Chamoux, Nicolas, Combaret, Nicolas, Malclès, Guilhem, Souteyrand, Géraud, Cottin, Yves, Buffet, Philippe, Gudjonvick, Aurélie, L’Huillier, Isabelle, Lorgis, Luc, Richard, Carole, Bertrand, Bernard, Baronne-Rochette, Gilles, Bouvaist, Hélène, Marlière, Stéphanie, Ormezzano, Olivier, Vanzetto, Gérald, Meunier, Ludovic, Trouillet, Charlotte, Valy, Yann, Lesault, Pierre-François, VanBelle, Eric, Bauters, Christophe, Delhaye, Cédric, Lemesle, Gilles, Rihani, Riadh, Graux, Pierre, Lemahieu, Jean-Michel, Harbaoui, Brahim, Besnard, Cyril, Courand, Pierre-Yves, Dauphin, Raphaël, Lantelme, Pierre, Perret, Thibault, Caignault, Jean-Raymond, Dubreuil, Olivier, Ranc, Sylvain, Ritz, Bernard, Rioufol, Gilles, Bergerot, Cyrille, Bochaton, Thomas, Bonnefoy-Cudraz, Eric, Bresson, Didier, Dementhon, Julie, Derimay, François, Finet, Gérard, Green, Lisa, Prieur, Cyril, Sanchez, Ingrid, Zouaghi, Oualid, Arméro, Sébastien, Lefèvre, Thierry, Ben-Amer, Hakim, Chevalier, Bernard, Garot, Philippe, Hovasse, Thomas, Louvard, Yves, Morice, Marie-Claude, Tavolaro, Oscar, Unterseeh, Thierry, Dupouy, Patrick, Roubille, François, Cung, DinhThienTri, Macia, Jean-Christophe, Piot, Christophe, Levy, Gilles, Roth, Olivier, Jacquemin, Laurent, Wiedemann, Jean-Yves, Cayla, Guillaume, Cornillet, Luc, Ledermann, Bertrand, Schmutz, Laurent, Lafont, Antoine, Karam, Nicole, Rahal, Saliha, Caussin, Christophe, Amabile, Nicolas, Girard, Philippe, Veugeois, Aurélie, Barthélémy, Olivier, Collet, Jean-Philippe, Montalescot, Gilles, Koning, René, Berland, Jacques, Godin, Matthieu, Landolff, Quentin, Zoghlami, Bilel, Pouillot, Christophe, Bougrini, Karim, Geyer, Christophe, Glanenapp, Jens, Mascarel, Patrick, Rambaud, Geoffray, ViFane, Richard, Angoulvant, Denis, Desveaux, Bernard, Ivanes, Fabrice, Pacouret, Gérard, Quilliet, Laurent-Emmanuel, SaintEtienne, Christophe, Chapon, Philippe, Bretelle, Christophe, Champin, Stanislas, Dérimay, François, Van Belle, Éric, Morelle, Jean-François, Soto, François-Xavier, Barthelemy, Olivier, Armero, Sébastien, Amaz, Camille, Vaz, Bernadette, Benyahya, Lakhdar, Varillon, Yvonne, Ovize, Michel, and Mewton, Nathan

Published
2021
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5. Recommandations sur la mesure de la pression artérielle. Consensus d’experts de la Société française d’hypertension artérielle, filiale de la Société française de cardiologie

Author

Asmar, Roland, Boivin, Jean-Marc, Girerd, Xavier, Le Jeune, Sylvain, Vaisse, Bernard, Antakly-Hanon, Yara, Artifoni, Mathieu, Atallah, André, Bachelet, Christophe, Barber-Chamoux, Nicolas, Bejan-Angoulvant, Theodora, Blacher, Jacques, Boulestreau, Romain, Chantrel, François, Dimitrov, Yves, Doll, Gérard, Dugelay, Giselle, Duly-Bouhanick, Béatrice, Gosse, Philippe, Guerrot, Dominique, Jarraya, Faiçal, Lamirault, Guillaume, Lequeux, Benoit, Lopez-Sublet, Marilucy, Mercier, Alain, Millet, Laurène, Mounier-Véhier, Claire, Mourad, Jean-Jacques, Nasr, Edgar, Ormezzano, Olivier, Perez, Laurence, Persu, Alexandre, Ribstein, Jean, Silhol, François, Sosner, Philippe, Steyer, Elisabeth, Temmar, Mohamed, Van De Borne, Philippe, Vidal-Petiot, Emmanuelle, and Denolle, Thierry

Published
2019
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6. 6- Versus 24-Month Dual Antiplatelet Therapy After Implantation of Drug-Eluting Stents in Patients Nonresistant to Aspirin: Final Results of the ITALIC Trial (Is There a Life for DES After Discontinuation of Clopidogrel)

Author

Didier, Romain, Morice, Marie Claude, Barragan, Paul, Noryani, Arif A.L., Noor, Hussam A., Majwal, Talib, Hovasse, Thomas, Castellant, Philippe, Schneeberger, Michel, Maillard, Luc, Bressolette, Erwan, Wojcik, Jaroslaw, Delarche, Nicolas, Blanchard, Didier, Jouve, Bernard, Ormezzano, Olivier, Paganelli, Franck, Levy, Gilles, Sainsous, Joël, Carrie, Didier, Furber, Alain, Berlan, Jacques, Darremont, Olivier, Le Breton, Hervé, Lyuycx-Bore, Anne, Gommeaux, Antoine, Cassat, Claude, Kermarrec, Alain, Cazaux, Pierre, Druelles, Philippe, Dauphin, Raphael, Armengaud, Jean, Dupouy, Patrick, Champagnac, Didier, Ohlmann, Patrick, Ben Amer, Hakim, Kiss, Robert G., Ungi, Irme, and Gilard, Martine

Published
2017
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7. Clinic Versus Ambulatory Blood Pressure in Resistant Hypertension: Impact of Antihypertensive Medication Nonadherence: A Post Hoc Analysis the DENERHTN Study

Author

Hamdidouche, Idir, Gosse, Philippe, Cremer, Antoine, Lorthioir, Aurelien, Delsart, Pascal, Courand, Pierre-Yves, Denolle, Thierry, Halimi, Jean-Michel, Girerd, Xavier, Ormezzano, Olivier, Rossignol, Patrick, Pereira, Helena, Azizi, Michel, Amar, L, Bobrie, G, Monge, M, Pagny, JY, Sapoval, M, Claisse, G, Midulla, M, Mounier-Vehier, C, Dauphin, R, Fauvel, JP, Lantelme, P, Rouvière, O, Grenier, N, Lebras, Y, Trillaud, H, Dourmap, C, Heautot, JF, Larralde, A, Paillard, F, Cluzel, P, Rosenbaum, D, Alison, D, Popovic, B, Zannad, F, Baguet, JP, Thony, F, Bartoli, JM, Vaïsse, B, Drouineau, J, Herpin, D, Sosner, P, Tasu, JP, Velasco, S, Ribstein, J, Kovacsik, H, Bouhanick, B, Chamontin, B, Rousseau, H, Le Jeune, S, Lopez-Sublet, M, Mourad, JJ, Bellmann, L, Esnault, V, Ferrari, E, and Chatellier, G.

Published
2019
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9. 6- Versus 24-Month Dual Antiplatelet Therapy After Implantation of Drug-Eluting Stents in Patients Nonresistant to Aspirin: The Randomized, Multicenter ITALIC Trial

Author

Gilard, Martine, Barragan, Paul, Noryani, Arif A.L., Noor, Hussam A., Majwal, Talib, Hovasse, Thomas, Castellant, Philippe, Schneeberger, Michel, Maillard, Luc, Bressolette, Erwan, Wojcik, Jaroslaw, Delarche, Nicolas, Blanchard, Didier, Jouve, Bernard, Ormezzano, Olivier, Paganelli, Franck, Levy, Gilles, Sainsous, Joël, Carrie, Didier, Furber, Alain, Berland, Jacques, Darremont, Oliver, Le Breton, Hervé, Lyuycx-Bore, Anne, Gommeaux, Antoine, Cassat, Claude, Kermarrec, Alain, Cazaux, Pierre, Druelles, Philippe, Dauphin, Raphael, Armengaud, Jean, Dupouy, Patrick, Champagnac, Didier, Ohlmann, Patrick, Endresen, Knut, Benamer, Hakim, Kiss, Robert Gabor, Ungi, Imre, Boschat, Jacques, and Morice, Marie-Claude

Published
2015
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10. Dual endothelin antagonist aprocitentan for resistant hypertension (PRECISION): a multicentre, blinded, randomised, parallel-group, phase 3 trial

Author

Schlaich, Markus P, primary, Bellet, Marc, additional, Weber, Michael A, additional, Danaietash, Parisa, additional, Bakris, George L, additional, Flack, John M, additional, Dreier, Roland F, additional, Sassi-Sayadi, Mouna, additional, Haskell, Lloyd P, additional, Narkiewicz, Krzysztof, additional, Wang, Ji-Guang, additional, Reid, Christopher, additional, Schlaich, Markus, additional, Katz, Ivor, additional, Ajani, Andrew, additional, Biswas, Sinjini, additional, Esler, Murray, additional, Elder, Grahame, additional, Roger, Simon, additional, Colquhoun, David, additional, Mooney, John, additional, De Backer, Tine, additional, Persu, Alexandre, additional, Chaumont, Martin, additional, Krzesinski, Jean-Marie, additional, Vanassche, Thomas, additional, Girard, Ginette, additional, Pliamm, Lew, additional, Schiffrin, Ernesto, additional, Merali, Fatima, additional, Dresser, George, additional, Vallee, Michel, additional, Jolly, Shivinder, additional, Chow, Stephen, additional, Wang, Jiguang, additional, Mu, Jianjun, additional, Yu, Jing, additional, Yuan, Hong, additional, Feng, Yingqing, additional, Zhang, Xin, additional, Xie, Jianhong, additional, Lin, Ling, additional, Soucek, Miroslav, additional, Widimsky, Jiri, additional, Cifkova, Renata, additional, Vaclavik, Jan, additional, Ullrych, Martin, additional, Lukac, Martin, additional, Rychlik, Ivan, additional, Guldager Lauridsen, Thomas, additional, Kantola, Ilkka, additional, Taurio, Jyrki, additional, Ukkola, Olavi, additional, Ormezzano, Olivier, additional, Gosse, Philippe, additional, Azizi, Michel, additional, Courand, Pierre-Yves, additional, Delsart, Pascal, additional, Tartiere, Jean Michel, additional, Mahfoud, Felix, additional, Schmieder, Roland, additional, Stegbauer, Johannes, additional, Lurz, Philipp, additional, Koziolek, Michael, additional, Ott, Christian, additional, Toursarkissian, Nicole, additional, Tsioufis, Konstantinos, additional, Kyfnidis, Konstantinos, additional, Manolis, Athanasios, additional, Patsilinakos, Sotirios, additional, Zebekakis, Pantelis, additional, Karavidas, Apostolos, additional, Denes, Pall, additional, Bezzegh, Katalin, additional, Zsom, Marianna, additional, Kovacs, Laszlo, additional, Sharabi, Yehonatan, additional, Elias, Mazen, additional, Sukholutsky, Ivetta, additional, Yosefy, Chaim, additional, Kenis, Irina, additional, Atar, Shaul, additional, Volpe, Massimo, additional, Maria Lorenza, Muiesan, additional, Taddei, Stefano, additional, Grassi, Guido, additional, Veglio, Franco, additional, Son, Jung Woo, additional, Kim, Jang-Young, additional, Park, Joong-Il, additional, Lee, Chang Hoon, additional, Lee, Hae-Young, additional, Raugaliene, Rasa, additional, Marcinkeviciene, Jolanta Elena, additional, Kavaliauskiene, Roma, additional, Deinum, Jaap, additional, Kroon, Abraham, additional, van den Born, Bert-Jan, additional, Januszewicz, Andrzej, additional, Tykarski, Andrzej, additional, Walczewska, Jolanta, additional, Gaciong, Zbigniew, additional, Wiecek, Andrzej, additional, Chrostowska, Marzena, additional, Kleinrok, Andrzej, additional, Krekora, Jan, additional, Kania, Grzegorz, additional, Podrazka-Szczepaniak, Anna, additional, Golawski, Cezary, additional, Podziewski, Maciej, additional, Kaczmarek, Barbara, additional, Skoczylas, Grzegorz, additional, Wilkolaski, Andrzej, additional, Wozniak, Iwona, additional, Janik-Palazzolo, Marzena, additional, Rewerska, Barbara, additional, Konradi, Aleksandra, additional, Shvarts, Yuriy, additional, Pecherina, Tamara, additional, Nikolaev, Konstantin, additional, Liudmila, Gapon, additional, Orlikova, Olga, additional, Mordovin, Viktor, additional, Petrochenkova, Natalia, additional, Kamalov, Gadel, additional, Kosmacheva, Elena, additional, Tyrenko, Vadim, additional, Gorbunov, Vladimir, additional, Obrezan, Andrey, additional, Supryadkina, Tatiana, additional, Ler, Irina, additional, Kotenko, Oleg, additional, Kuzin, Anatoly, additional, Martínez García, Fernando, additional, Redon, Josep, additional, Oliveras, Anna, additional, Beltran Romero, Luis, additional, Shatylo, Valerii, additional, Rudenko, Leonid, additional, Bazylevych, Andriy, additional, Rudyk, Yurii, additional, Karpenko, Oleksandr, additional, Stanislavchuk, Mykola, additional, Tseluyko, Vira, additional, Kushnir, Mykola, additional, Asanov, Ervin, additional, Sirenko, Yuriy, additional, Yagensky, Andriy, additional, Collier, David, additional, Gupta, Pankaj, additional, Webb, David, additional, MacLeod, Mary, additional, McLay, James, additional, Peace, Aaron, additional, Arora, Samir, additional, Buchanan, Patricia, additional, Harris, Robert, additional, Degarmo, Ronald, additional, Guillen, Mario, additional, Karns, Adam, additional, Neutel, Joel, additional, Paliwal, Yogesh, additional, Pettis, Karlton, additional, Toth, Phillip D., additional, Wayne, Jeffrey M., additional, Butcher, Michael Bain, additional, Diller, Phillip M., additional, Oparil, Suzanne, additional, Calhoun, David, additional, Brautigam, Donald, additional, Flack, John, additional, Goldman, Jesse M., additional, Rashidi, Arash, additional, Aslam, Nabeel, additional, Haley, William, additional, Andrawis, Nabil, additional, Lang, Brian, additional, Miller, Randy, additional, Powell, James, additional, Dewhurst, Robert, additional, Pritchard, James, additional, Khanna, Dinesh, additional, Tang, Dennis, additional, Gabra, Nashwa, additional, Park, Jean, additional, Jones, Conigliaro, additional, Scott, Cranford, additional, Luna, Blanca, additional, Mussaji, Murtaza, additional, Bhagwat, Ravi, additional, Bauer, Michael, additional, McGinty, John, additional, Nambiar, Rajesh, additional, Sangrigoli, Renee, additional, Davis, William Ross, additional, Eaves, William, additional, McGrew, Frank, additional, Awad, Ahmed, additional, Bolster, Eric, additional, Scott, David, additional, Kalirao, Paramjit, additional, Dabel, Pascal, additional, Calhoun, Wesley, additional, Gouge, Steven, additional, Warren, Mark, additional, Lawrence, Mary Katherine, additional, Jamal, Aamir, additional, El-Shahawy, Mohamed, additional, Mercado, Carlos, additional, Kumar, Jayant, additional, Velasquez-Mieyer, Pedro, additional, Busch, Robert, additional, Lewis, Todd, additional, and Rich, Lisa, additional

Published
2022
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14. Dual endothelin antagonist aprocitentan for resistant hypertension (PRECISION): a multicentre, blinded, randomised, parallel-group, phase 3 trial

Author

Schlaich, M, Bellet, M, Weber, M, Danaietash, P, Bakris, G, Flack, J, Dreier, R, Sassi-Sayadi, M, Haskell, L, Narkiewicz, K, Wang, J, Reid, C, Katz, I, Ajani, A, Biswas, S, Esler, M, Elder, G, Roger, S, Colquhoun, D, Mooney, J, De Backer, T, Persu, A, Chaumont, M, Krzesinski, J, Vanabsche, T, Girard, G, Pliamm, L, Schiffrin, E, Merali, F, Dresser, G, Vallee, M, Jolly, S, Chow, S, Mu, J, Yu, J, Yuan, H, Feng, Y, Zhang, X, Xie, J, Lin, L, Soucek, M, Widimsky, J, Cifkova, R, Vaclavik, J, Ullrych, M, Lukac, M, Rychlik, I, Guldager Lauridsen, T, Kantola, I, Taurio, J, Ukkola, O, Ormezzano, O, Gosse, P, Azizi, M, Courand, P, Delsart, P, Tartiere, J, Mahfoud, F, Schmieder, R, Stegbauer, J, Lurz, P, Koziolek, M, Ott, C, Toursarkissian, N, Tsioufis, K, Kyfnidis, K, Manolis, A, Patsilinakos, S, Zebekakis, P, Karavidas, A, Denes, P, Bezzegh, K, Zsom, M, Kovacs, L, Sharabi, Y, Elias, M, Sukholutsky, I, Yosefy, C, Kenis, I, Atar, S, Volpe, M, Lorenza, M, Taddei, S, Grassi, G, Veglio, F, Son, J, Kim, J, Park, J, Lee, C, Lee, H, Raugaliene, R, Marcinkeviciene, J, Kavaliauskiene, R, Deinum, J, Kroon, A, van den Born, B, Januszewicz, A, Tykarski, A, Walczewska, J, Gaciong, Z, Wiecek, A, Chrostowska, M, Kleinrok, A, Krekora, J, Kania, G, Podrazka-Szczepaniak, A, Golawski, C, Podziewski, M, Kaczmarek, B, Skoczylas, G, Wilkolaski, A, Wozniak, I, Janik-Palazzolo, M, Rewerska, B, Konradi, A, Shvarts, Y, Pecherina, T, Nikolaev, K, Liudmila, G, Orlikova, O, Mordovin, V, Petrochenkova, N, Kamalov, G, Kosmacheva, E, Tyrenko, V, Gorbunov, V, Obrezan, A, Supryadkina, T, Ler, I, Kotenko, O, Kuzin, A, Martinez, F, Redon, J, Oliveras, A, Beltran Romero, L, Shatylo, V, Rudenko, L, Bazylevych, A, Rudyk, Y, Karpenko, O, Stanislavchuk, M, Tseluyko, V, Kushnir, M, Asanov, E, Sirenko, Y, Yagensky, A, Collier, D, Gupta, P, Webb, D, Macleod, M, Mclay, J, Peace, A, Arora, S, Buchanan, P, Harris, R, Degarmo, R, Guillen, M, Karns, A, Neutel, J, Paliwal, Y, Pettis, K, Toth, P, Wayne, J, Butcher, B, Diller, P, Oparil, S, Calhoun, D, Brautigam, D, Goldman, J, Rashidi, A, Aslam, N, Haley, W, Andrawis, N, Lang, B, Miller, R, Powell, J, Dewhurst, R, Pritchard, J, Khanna, D, Tang, D, Gabra, N, Jones, C, Scott, C, Luna, B, Mussaji, M, Bhagwat, R, Bauer, M, Mcginty, J, Nambiar, R, Sangrigoli, R, Ross Davis, W, Eaves, W, Mcgrew, F, Awad, A, Bolster, E, Scott, D, Kalirao, P, Dabel, P, Calhoun, W, Gouge, S, Warren, M, Lawrence, M, Jamal, A, El-Shahawy, M, Mercado, C, Kumar, J, Velasquez-Mieyer, P, Busch, R, Lewis, T, Rich, L, Schlaich, Markus P, Bellet, Marc, Weber, Michael A, Danaietash, Parisa, Bakris, George L, Flack, John M, Dreier, Roland F, Sassi-Sayadi, Mouna, Haskell, Lloyd P, Narkiewicz, Krzysztof, Wang, Ji-Guang, Reid, Christopher, Schlaich, Markus, Katz, Ivor, Ajani, Andrew, Biswas, Sinjini, Esler, Murray, Elder, Grahame, Roger, Simon, Colquhoun, David, Mooney, John, De Backer, Tine, Persu, Alexandre, Chaumont, Martin, Krzesinski, Jean-Marie, Vanabsche, Thomas, Girard, Ginette, Pliamm, Lew, Schiffrin, Ernesto, Merali, Fatima, Dresser, George, Vallee, Michel, Jolly, Shivinder, Chow, Stephen, Wang, Jiguang, Mu, Jianjun, Yu, Jing, Yuan, Hong, Feng, Yingqing, Zhang, Xin, Xie, Jianhong, Lin, Ling, Soucek, Miroslav, Widimsky, Jiri, Cifkova, Renata, Vaclavik, Jan, Ullrych, Martin, Lukac, Martin, Rychlik, Ivan, Guldager Lauridsen, Thomas, Kantola, Ilkka, Taurio, Jyrki, Ukkola, Olavi, Ormezzano, Olivier, Gosse, Philippe, Azizi, Michel, Courand, Pierre-Yves, Delsart, Pascal, Tartiere, Jean Michel, Mahfoud, Felix, Schmieder, Roland, Stegbauer, Johannes, Lurz, Philipp, Koziolek, Michael, Ott, Christian, Toursarkissian, Nicole, Tsioufis, Konstantinos, Kyfnidis, Konstantinos, Manolis, Athanasios, Patsilinakos, Sotirios, Zebekakis, Pantelis, Karavidas, Apostolos, Denes, Pall, Bezzegh, Katalin, Zsom, Marianna, Kovacs, Laszlo, Sharabi, Yehonatan, Elias, Mazen, Sukholutsky, Ivetta, Yosefy, Chaim, Kenis, Irina, Atar, Shaul, Volpe, Massimo, Lorenza, Muiesan Maria, Taddei, Stefano, Grassi, Guido, Veglio, Franco, Son, Jung Woo, Kim, Jang-Young, Park, Joong-Il, Lee, Chang Hoon, Lee, Hae-Young, Raugaliene, Rasa, Marcinkeviciene, Jolanta Elena, Kavaliauskiene, Roma, Deinum, Jaap, Kroon, Abraham, van den Born, Bert-Jan, Januszewicz, Andrzej, Tykarski, Andrzej, Walczewska, Jolanta, Gaciong, Zbigniew, Wiecek, Andrzej, Chrostowska, Marzena, Kleinrok, Andrzej, Krekora, Jan, Kania, Grzegorz, Podrazka-Szczepaniak, Anna, Golawski, Cezary, Podziewski, Maciej, Kaczmarek, Barbara, Skoczylas, Grzegorz, Wilkolaski, Andrzej, Wozniak, Iwona, Janik-Palazzolo, Marzena, Rewerska, Barbara, Konradi, Alexandra, Shvarts, Yuriy, Pecherina, Tamara, Nikolaev, Konstantin, Liudmila, Gapon, Orlikova, Olga, Mordovin, Viktor, Petrochenkova, Natalia, Kamalov, Gadel, Kosmacheva, Elena, Tyrenko, Vadim, Gorbunov, Vladimir, Obrezan, Andrey, Supryadkina, Tatiana, Ler, Irina, Kotenko, Oleg, Kuzin, Anatoly, Martinez, Fernando, Redon, Josep, Oliveras, Anna, Beltran Romero, Luis, Shatylo, Valerii, Rudenko, Leonid, Bazylevych, Andriiy, Rudyk, Yurii, Karpenko, Oleksandr, Stanislavchuk, Mykola, Tseluyko, Vira, Kushnir, Mykola, Asanov, Ervin, Sirenko, Yuriy, Yagensky, Andriy, Collier, David, Gupta, Pankaj, Webb, David, MacLeod, Mary, McLay, James, Peace, Aaron, Arora, Samir, Buchanan, Patricia, Harris, Robert, Degarmo, Ronald, Guillen, Mario, Karns, Adam, Neutel, Joel, Paliwal, Yogesh, Pettis, Karlton, Toth, Phillip D., Wayne, Jeffrey M., Butcher, Bain, Diller, Phillip M., Oparil, Suzanne, Calhoun, David, Brautigam, Donald, Flack, John, Goldman, Jesse M., Rashidi, Arash, Aslam, Nabeel, Haley, William, Andrawis, Nabil, Lang, Brian, Miller, Randy, Powell, James, Dewhurst, Robert, Pritchard, James, Khanna, Dinesh, Tang, Dennis, Gabra, Nashwa, Park, Jean, Jones, Conigliaro, Scott, Cranford, Luna, Blanca, Mussaji, Murtaza, Bhagwat, Ravi, Bauer, Michael, McGinty, John, Nambiar, Rajesh, Sangrigoli, Renee, Ross Davis, William, Eaves, William, McGrew, Frank, Awad, Ahmed, Bolster, Eric, Scott, David, Kalirao, Paramjit, Dabel, Pascal, Calhoun, Wesley, Gouge, Steven, Warren, Mark, Lawrence, Mary Katherine, Jamal, Aamir, El-Shahawy, Mohamed, Mercado, Carlos, Kumar, Jayant, Velasquez-Mieyer, Pedro, Busch, Robert, Lewis, Todd, Rich, Lisa, Schlaich, M, Bellet, M, Weber, M, Danaietash, P, Bakris, G, Flack, J, Dreier, R, Sassi-Sayadi, M, Haskell, L, Narkiewicz, K, Wang, J, Reid, C, Katz, I, Ajani, A, Biswas, S, Esler, M, Elder, G, Roger, S, Colquhoun, D, Mooney, J, De Backer, T, Persu, A, Chaumont, M, Krzesinski, J, Vanabsche, T, Girard, G, Pliamm, L, Schiffrin, E, Merali, F, Dresser, G, Vallee, M, Jolly, S, Chow, S, Mu, J, Yu, J, Yuan, H, Feng, Y, Zhang, X, Xie, J, Lin, L, Soucek, M, Widimsky, J, Cifkova, R, Vaclavik, J, Ullrych, M, Lukac, M, Rychlik, I, Guldager Lauridsen, T, Kantola, I, Taurio, J, Ukkola, O, Ormezzano, O, Gosse, P, Azizi, M, Courand, P, Delsart, P, Tartiere, J, Mahfoud, F, Schmieder, R, Stegbauer, J, Lurz, P, Koziolek, M, Ott, C, Toursarkissian, N, Tsioufis, K, Kyfnidis, K, Manolis, A, Patsilinakos, S, Zebekakis, P, Karavidas, A, Denes, P, Bezzegh, K, Zsom, M, Kovacs, L, Sharabi, Y, Elias, M, Sukholutsky, I, Yosefy, C, Kenis, I, Atar, S, Volpe, M, Lorenza, M, Taddei, S, Grassi, G, Veglio, F, Son, J, Kim, J, Park, J, Lee, C, Lee, H, Raugaliene, R, Marcinkeviciene, J, Kavaliauskiene, R, Deinum, J, Kroon, A, van den Born, B, Januszewicz, A, Tykarski, A, Walczewska, J, Gaciong, Z, Wiecek, A, Chrostowska, M, Kleinrok, A, Krekora, J, Kania, G, Podrazka-Szczepaniak, A, Golawski, C, Podziewski, M, Kaczmarek, B, Skoczylas, G, Wilkolaski, A, Wozniak, I, Janik-Palazzolo, M, Rewerska, B, Konradi, A, Shvarts, Y, Pecherina, T, Nikolaev, K, Liudmila, G, Orlikova, O, Mordovin, V, Petrochenkova, N, Kamalov, G, Kosmacheva, E, Tyrenko, V, Gorbunov, V, Obrezan, A, Supryadkina, T, Ler, I, Kotenko, O, Kuzin, A, Martinez, F, Redon, J, Oliveras, A, Beltran Romero, L, Shatylo, V, Rudenko, L, Bazylevych, A, Rudyk, Y, Karpenko, O, Stanislavchuk, M, Tseluyko, V, Kushnir, M, Asanov, E, Sirenko, Y, Yagensky, A, Collier, D, Gupta, P, Webb, D, Macleod, M, Mclay, J, Peace, A, Arora, S, Buchanan, P, Harris, R, Degarmo, R, Guillen, M, Karns, A, Neutel, J, Paliwal, Y, Pettis, K, Toth, P, Wayne, J, Butcher, B, Diller, P, Oparil, S, Calhoun, D, Brautigam, D, Goldman, J, Rashidi, A, Aslam, N, Haley, W, Andrawis, N, Lang, B, Miller, R, Powell, J, Dewhurst, R, Pritchard, J, Khanna, D, Tang, D, Gabra, N, Jones, C, Scott, C, Luna, B, Mussaji, M, Bhagwat, R, Bauer, M, Mcginty, J, Nambiar, R, Sangrigoli, R, Ross Davis, W, Eaves, W, Mcgrew, F, Awad, A, Bolster, E, Scott, D, Kalirao, P, Dabel, P, Calhoun, W, Gouge, S, Warren, M, Lawrence, M, Jamal, A, El-Shahawy, M, Mercado, C, Kumar, J, Velasquez-Mieyer, P, Busch, R, Lewis, T, Rich, L, Schlaich, Markus P, Bellet, Marc, Weber, Michael A, Danaietash, Parisa, Bakris, George L, Flack, John M, Dreier, Roland F, Sassi-Sayadi, Mouna, Haskell, Lloyd P, Narkiewicz, Krzysztof, Wang, Ji-Guang, Reid, Christopher, Schlaich, Markus, Katz, Ivor, Ajani, Andrew, Biswas, Sinjini, Esler, Murray, Elder, Grahame, Roger, Simon, Colquhoun, David, Mooney, John, De Backer, Tine, Persu, Alexandre, Chaumont, Martin, Krzesinski, Jean-Marie, Vanabsche, Thomas, Girard, Ginette, Pliamm, Lew, Schiffrin, Ernesto, Merali, Fatima, Dresser, George, Vallee, Michel, Jolly, Shivinder, Chow, Stephen, Wang, Jiguang, Mu, Jianjun, Yu, Jing, Yuan, Hong, Feng, Yingqing, Zhang, Xin, Xie, Jianhong, Lin, Ling, Soucek, Miroslav, Widimsky, Jiri, Cifkova, Renata, Vaclavik, Jan, Ullrych, Martin, Lukac, Martin, Rychlik, Ivan, Guldager Lauridsen, Thomas, Kantola, Ilkka, Taurio, Jyrki, Ukkola, Olavi, Ormezzano, Olivier, Gosse, Philippe, Azizi, Michel, Courand, Pierre-Yves, Delsart, Pascal, Tartiere, Jean Michel, Mahfoud, Felix, Schmieder, Roland, Stegbauer, Johannes, Lurz, Philipp, Koziolek, Michael, Ott, Christian, Toursarkissian, Nicole, Tsioufis, Konstantinos, Kyfnidis, Konstantinos, Manolis, Athanasios, Patsilinakos, Sotirios, Zebekakis, Pantelis, Karavidas, Apostolos, Denes, Pall, Bezzegh, Katalin, Zsom, Marianna, Kovacs, Laszlo, Sharabi, Yehonatan, Elias, Mazen, Sukholutsky, Ivetta, Yosefy, Chaim, Kenis, Irina, Atar, Shaul, Volpe, Massimo, Lorenza, Muiesan Maria, Taddei, Stefano, Grassi, Guido, Veglio, Franco, Son, Jung Woo, Kim, Jang-Young, Park, Joong-Il, Lee, Chang Hoon, Lee, Hae-Young, Raugaliene, Rasa, Marcinkeviciene, Jolanta Elena, Kavaliauskiene, Roma, Deinum, Jaap, Kroon, Abraham, van den Born, Bert-Jan, Januszewicz, Andrzej, Tykarski, Andrzej, Walczewska, Jolanta, Gaciong, Zbigniew, Wiecek, Andrzej, Chrostowska, Marzena, Kleinrok, Andrzej, Krekora, Jan, Kania, Grzegorz, Podrazka-Szczepaniak, Anna, Golawski, Cezary, Podziewski, Maciej, Kaczmarek, Barbara, Skoczylas, Grzegorz, Wilkolaski, Andrzej, Wozniak, Iwona, Janik-Palazzolo, Marzena, Rewerska, Barbara, Konradi, Alexandra, Shvarts, Yuriy, Pecherina, Tamara, Nikolaev, Konstantin, Liudmila, Gapon, Orlikova, Olga, Mordovin, Viktor, Petrochenkova, Natalia, Kamalov, Gadel, Kosmacheva, Elena, Tyrenko, Vadim, Gorbunov, Vladimir, Obrezan, Andrey, Supryadkina, Tatiana, Ler, Irina, Kotenko, Oleg, Kuzin, Anatoly, Martinez, Fernando, Redon, Josep, Oliveras, Anna, Beltran Romero, Luis, Shatylo, Valerii, Rudenko, Leonid, Bazylevych, Andriiy, Rudyk, Yurii, Karpenko, Oleksandr, Stanislavchuk, Mykola, Tseluyko, Vira, Kushnir, Mykola, Asanov, Ervin, Sirenko, Yuriy, Yagensky, Andriy, Collier, David, Gupta, Pankaj, Webb, David, MacLeod, Mary, McLay, James, Peace, Aaron, Arora, Samir, Buchanan, Patricia, Harris, Robert, Degarmo, Ronald, Guillen, Mario, Karns, Adam, Neutel, Joel, Paliwal, Yogesh, Pettis, Karlton, Toth, Phillip D., Wayne, Jeffrey M., Butcher, Bain, Diller, Phillip M., Oparil, Suzanne, Calhoun, David, Brautigam, Donald, Flack, John, Goldman, Jesse M., Rashidi, Arash, Aslam, Nabeel, Haley, William, Andrawis, Nabil, Lang, Brian, Miller, Randy, Powell, James, Dewhurst, Robert, Pritchard, James, Khanna, Dinesh, Tang, Dennis, Gabra, Nashwa, Park, Jean, Jones, Conigliaro, Scott, Cranford, Luna, Blanca, Mussaji, Murtaza, Bhagwat, Ravi, Bauer, Michael, McGinty, John, Nambiar, Rajesh, Sangrigoli, Renee, Ross Davis, William, Eaves, William, McGrew, Frank, Awad, Ahmed, Bolster, Eric, Scott, David, Kalirao, Paramjit, Dabel, Pascal, Calhoun, Wesley, Gouge, Steven, Warren, Mark, Lawrence, Mary Katherine, Jamal, Aamir, El-Shahawy, Mohamed, Mercado, Carlos, Kumar, Jayant, Velasquez-Mieyer, Pedro, Busch, Robert, Lewis, Todd, and Rich, Lisa

Abstract

Background: Resistant hypertension is associated with increased cardiovascular risk. The endothelin pathway has been implicated in the pathogenesis of hypertension, but it is currently not targeted therapeutically, thereby leaving this relevant pathophysiological pathway unopposed with currently available drugs. The aim of the study was to assess the blood pressure lowering efficacy of the dual endothelin antagonist aprocitentan in patients with resistant hypertension. Methods: PRECISION was a multicentre, blinded, randomised, parallel-group, phase 3 study, which was done in hospitals or research centres in Europe, North America, Asia, and Australia. Patients were eligible for randomisation if their sitting systolic blood pressure was 140 mm Hg or higher despite taking standardised background therapy consisting of three antihypertensive drugs, including a diuretic. The study consisted of three sequential parts: part 1 was the 4-week double-blind, randomised, and placebo-controlled part, in which patients received aprocitentan 12·5 mg, aprocitentan 25 mg, or placebo in a 1:1:1 ratio; part 2 was a 32-week single (patient)-blind part, in which all patients received aprocitentan 25 mg; and part 3 was a 12-week double-blind, randomised, and placebo-controlled withdrawal part, in which patients were re-randomised to aprocitentan 25 mg or placebo in a 1:1 ratio. The primary and key secondary endpoints were changes in unattended office systolic blood pressure from baseline to week 4 and from withdrawal baseline to week 40, respectively. Secondary endpoints included 24-h ambulatory blood pressure changes. The study is registered on ClinicalTrials.gov, NCT03541174. Findings: The PRECISION study was done from June 18, 2018, to April 25, 2022. 1965 individuals were screened and 730 were randomly assigned. Of these 730 patients, 704 (96%) completed part 1 of the study; of these, 613 (87%) completed part 2 and, of these, 577 (94%) completed part 3 of the study. The least square m

Published
2022

15. High Prevalence of Multiple Arterial Bed Lesions in Patients With Fibromuscular Dysplasia: The ARCADIA Registry (Assessment of Renal and Cervical Artery Dysplasia)

Author

Plouin, Pierre-François, Baguet, Jean-Philippe, Thony, Frédéric, Ormezzano, Olivier, Azarine, Arshid, Silhol, François, Oppenheim, Catherine, Bouhanick, Béatrice, Boyer, Louis, Persu, Alexandre, Hammer, Frank, Gosse, Philippe, Mounier-Vehier, Claire, Le Hello, Claire, Jeunemaitre, Xavier, Azizi, Michel, Amar, Laurence, Chatellier, Gilles, Mousseaux, Elie, and Touzé, Emmanuel

Published
2017
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16. Twenty-Four-Hour Blood Pressure Monitoring to Predict and Assess Impact of Renal Denervation: The DENERHTN Study (Renal Denervation for Hypertension)

Author

Gosse, Philippe, Cremer, Antoine, Pereira, Helena, Bobrie, Guillaume, Chatellier, Gilles, Chamontin, Bernard, Courand, Pierre-Yves, Delsart, Pascal, Denolle, Thierry, Dourmap, Caroline, Ferrari, Emile, Girerd, Xavier, Michel Halimi, Jean, Herpin, Daniel, Lantelme, Pierre, Monge, Matthieu, Mounier-Vehier, Claire, Mourad, Jean-Jacques, Ormezzano, Olivier, Ribstein, Jean, Rossignol, Patrick, Sapoval, Marc, Vaïsse, Bernard, Zannad, Faiez, and Azizi, Michel

Published
2017
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17. Prognostic significance of severe coronary microvascular dysfunction post-PCI in patients with STEMI: A systematic review and meta-analysis

Author

Canu, Marjorie, primary, Khouri, Charles, additional, Marliere, Stéphanie, additional, Vautrin, Estelle, additional, Piliero, Nicolas, additional, Ormezzano, Olivier, additional, Bertrand, Bernard, additional, Bouvaist, Hélène, additional, Riou, Laurent, additional, Djaileb, Loic, additional, Charlon, Clémence, additional, Vanzetto, Gerald, additional, Roustit, Matthieu, additional, and Barone-Rochette, Gilles, additional

Published
2022
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18. Fractional Flow Reserve to Guide Treatment of Patients With Multivessel Coronary Artery Disease

Author

Rioufol, Gilles, primary, Dérimay, François, additional, Roubille, François, additional, Perret, Thibault, additional, Motreff, Pascal, additional, Angoulvant, Denis, additional, Cottin, Yves, additional, Meunier, Ludovic, additional, Cetran, Laura, additional, Cayla, Guillaume, additional, Harbaoui, Brahim, additional, Wiedemann, Jean-Yves, additional, Van Belle, Éric, additional, Pouillot, Christophe, additional, Noirclerc, Nathalie, additional, Morelle, Jean-François, additional, Soto, François-Xavier, additional, Caussin, Christophe, additional, Bertrand, Bernard, additional, Lefèvre, Thierry, additional, Dupouy, Patrick, additional, Lesault, Pierre-François, additional, Albert, Franck, additional, Barthelemy, Olivier, additional, Koning, René, additional, Leborgne, Laurent, additional, Barnay, Pierre, additional, Chapon, Philippe, additional, Armero, Sébastien, additional, Lafont, Antoine, additional, Piot, Christophe, additional, Amaz, Camille, additional, Vaz, Bernadette, additional, Benyahya, Lakhdar, additional, Varillon, Yvonne, additional, Ovize, Michel, additional, Mewton, Nathan, additional, Finet, Gérard, additional, Fournier, Alexandre, additional, Jarry, Geneviève, additional, Leleu, François, additional, Malaquin, Dorothée, additional, Mirode, Anfani, additional, Belle, Loïc, additional, Mangin, Lionel, additional, Hirsch, Jean-Lou, additional, Metge, Marc, additional, Pansiery, Michel, additional, Soto, FrançoisXavier, additional, Boge, Antoine, additional, HadjHamou, Kamel, additional, Miliani, Ichem, additional, Molins, Guillaume, additional, Mourot, Stéphane, additional, Pelletier, Marion, additional, Ressencourt, Olivier, additional, Schaad, Frédéric, additional, Coste, Pierre, additional, Chasseriaud, Warren, additional, Poustis, Pierre, additional, Morelle, Jean-Francois, additional, Demicheli, Thibaud, additional, Range, Grégroire, additional, Thuaire, Christophe, additional, Barber-Chamoux, Nicolas, additional, Combaret, Nicolas, additional, Malclès, Guilhem, additional, Souteyrand, Géraud, additional, Buffet, Philippe, additional, Gudjonvick, Aurélie, additional, L’Huillier, Isabelle, additional, Lorgis, Luc, additional, Richard, Carole, additional, Baronne-Rochette, Gilles, additional, Bouvaist, Hélène, additional, Marlière, Stéphanie, additional, Ormezzano, Olivier, additional, Vanzetto, Gérald, additional, Trouillet, Charlotte, additional, Valy, Yann, additional, VanBelle, Eric, additional, Bauters, Christophe, additional, Delhaye, Cédric, additional, Lemesle, Gilles, additional, Rihani, Riadh, additional, Graux, Pierre, additional, Lemahieu, Jean-Michel, additional, Besnard, Cyril, additional, Courand, Pierre-Yves, additional, Dauphin, Raphaël, additional, Lantelme, Pierre, additional, Caignault, Jean-Raymond, additional, Dubreuil, Olivier, additional, Ranc, Sylvain, additional, Ritz, Bernard, additional, Rioufol, Gilles, additional, Bergerot, Cyrille, additional, Bochaton, Thomas, additional, Bonnefoy-Cudraz, Eric, additional, Bresson, Didier, additional, Dementhon, Julie, additional, Derimay, François, additional, Green, Lisa, additional, Prieur, Cyril, additional, Sanchez, Ingrid, additional, Zouaghi, Oualid, additional, Arméro, Sébastien, additional, Ben-Amer, Hakim, additional, Chevalier, Bernard, additional, Garot, Philippe, additional, Hovasse, Thomas, additional, Louvard, Yves, additional, Morice, Marie-Claude, additional, Tavolaro, Oscar, additional, Unterseeh, Thierry, additional, Cung, DinhThienTri, additional, Macia, Jean-Christophe, additional, Levy, Gilles, additional, Roth, Olivier, additional, Jacquemin, Laurent, additional, Cornillet, Luc, additional, Ledermann, Bertrand, additional, Schmutz, Laurent, additional, Karam, Nicole, additional, Rahal, Saliha, additional, Amabile, Nicolas, additional, Girard, Philippe, additional, Veugeois, Aurélie, additional, Barthélémy, Olivier, additional, Collet, Jean-Philippe, additional, Montalescot, Gilles, additional, Berland, Jacques, additional, Godin, Matthieu, additional, Landolff, Quentin, additional, Zoghlami, Bilel, additional, Bougrini, Karim, additional, Geyer, Christophe, additional, Glanenapp, Jens, additional, Mascarel, Patrick, additional, Rambaud, Geoffray, additional, ViFane, Richard, additional, Desveaux, Bernard, additional, Ivanes, Fabrice, additional, Pacouret, Gérard, additional, Quilliet, Laurent-Emmanuel, additional, SaintEtienne, Christophe, additional, Bretelle, Christophe, additional, and Champin, Stanislas, additional

Published
2021
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19. Male Sex Is Associated With Cervical Artery Dissection in Patients With Fibromuscular Dysplasia

Author

Arnaud, Charlotte, primary, Boulanger, Marion, additional, Lorthioir, Aurélien, additional, Amar, Laurence, additional, Azarine, Arshid, additional, Boyer, Louis, additional, Chatellier, Gilles, additional, Di Monaco, Silvia, additional, Jeunemaitre, Xavier, additional, Kastler, Adrian, additional, Mousseaux, Elie, additional, Oppenheim, Catherine, additional, Thony, Frédéric, additional, Persu, Alexandre, additional, Olin, Jeffrey W., additional, Azizi, Michel, additional, Touzé, Emmanuel, additional, Chedid, Antoine, additional, Fiquet, Béatrice, additional, Plouin, Pierre‐François, additional, Baguet, Jean‐Philippe, additional, Ormezzano, Olivier, additional, Silhol, François, additional, Bodiguel, Eric, additional, Domigo, Valérie, additional, Pasquini, Marta, additional, Trystram, Denis, additional, Clavelou, Pierre, additional, Chamontin, Bernard, additional, Duly‐Bouhanick, Béatrice, additional, Hénon, Hilde, additional, Mounier‐Vehier, Claire, additional, Astarci, Parla, additional, Goffette, Pierre, additional, Hammer, Frank, additional, Lengelé, Jean‐Philippe, additional, Severino, Francesca, additional, Verhelst, Robert, additional, Le Hello, Claire, additional, Gosse, Philippe, additional, Hervé, Dominique, additional, Pico, Fernando, additional, Kessler, Michèle, additional, Rossignol, Patrick, additional, Sanson, Yves, additional, Zuber, Mathieu, additional, Mazighi, Mikael, additional, and Alamowitch, Sonia, additional

Published
2021
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23. Impact of a micro‐net mesh technology covering stent on coronary microvascular dysfunction in patients with high thrombus burden

Author

Noirclerc, Nathalie, primary, Marliere, Stephanie, additional, Bakhti, Akader, additional, Mangin, Lionel, additional, Cassar, Emmanuel, additional, Vautrin, Estelle, additional, Piliero, Nicolas, additional, Ormezzano, Olivier, additional, Bouvaist, Helene, additional, Riou, Laurent, additional, Vanzetto, Gerald, additional, Belle, Loic, additional, and Barone‐Rochette, Gilles, additional

Published
2021
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24. Delayed expression of cytokines after reperfused myocardial infarction: possible trigger for cardiac dysfunction and ventricular remodeling

Author

Moro, Cecile, Jouan, Marie-Gabrielle, Rakotovao, Andry, Toufektsian, Marie-Claire, Ormezzano, Olivier, Nagy, Norbert, Tosaki, Arpad, Leiris, Joel de, and Boucher, Franqois

Subjects
Gene expression -- Research, Cytokines -- Properties, Heart attack -- Medical examination, Tumor necrosis factor -- Properties, Biological sciences
Abstract

Previous studies have shown that 1 wk after permanent coronary artery ligation in rats, some cellular mechanisms involving TNF-[alpha] occur and contribute to the development of cardiac dysfunction and subsequent heart failure. The aim of the present study was to determine whether similar phenomena also occur after ischemia-reperfusion and whether cytokines other than TNF-[alpha] can also be involved. Anesthetized male Wistar rats were subjected to 1 h coronary occlusion followed by reperfusion. Cardiac geometry and function were assessed by echocardiography at days 5, 7, 8, and 10 postligation. Before death, heart function was assessed in vivo under basal conditions, as well as after volume overload. Finally, hearts were frozen for histoenzymologic assessment of infarct size and remodeling. The profile of cardiac cytokines was determined by ELISA and ChemiArray on heart tissue extracts. As expected, ischemia-reperfusion induced a progressive remodeling of the heart, characterized by left ventricular free-wall thinning and cavity dilation. Heart function was also decreased in ischemic rats during the first week after surgery. Interestingly, a transient and marked increase in TNF-[alpha], IL-1[beta], IL-6, cytokine-induced neutrophil chemoattractant (CINC) 2, CINC3, and macrophage inflammatory protein-3a was also observed in the myocardium of myocardial ischemia (MI) animals at day 8, whereas the expression of anti-inflammatory interleukins IL-4 and IL-10 remained unchanged. These results suggest that overexpression of proinflammatory cytokines occurring during the first week after ischemia-reperfusion may play a role in the adaptative process in the myocardium and contribute to early dysfunction and remodeling. myocardial ischemia; tumor necrosis factor-[alpha]

Published
2007

27. [Expert consensus statement on blood pressure measurement from the French Society of Hypertension, an affiliate of the French Society of Cardiology]

Author

Denolle, Thierry, Asmar, Roland, Boivin, Jean-Marc, Girerd, Xavier, Le Jeune, Sylvain, Vaisse, Bernard, Antakly-Hanon, Yara, Artifoni, Mathieu, Atallah, André, Bachelet, Christophe, Barber-Chamoux, Nicolas, Bejan-Angoulvant, Theodora, Blacher, Jacques, Boulestreau, Romain, Chantrel, François, Dimitrov, Yves, Doll, Gérard, Dugelay, Giselle, Duly-Bouhanick, Béatrice, Gosse, Philippe, Guerrot, Dominique, Jarraya, Faiçal, Lamirault, Guillaume, Lequeux, Benoît, Lopez-Sublet, Marilucy, Mercier, Alain, Millet, Laurène, Mounier-Vehier, Claire, Mourad, Jean-Jacques, Nasr, Edgar, Ormezzano, Olivier, Perez, Laurence, Persu, Alexandre, Ribstein, Jean, Silhol, François, Sosner, Philippe, Steyer, Elisabeth, Temmar, Mohamed, Van De Borne, Philippe, Vidal-Petiot, Emmanuelle, Service de cardiologie et maladies vasculaires [CHU de Rennes], CHU Pontchaillou [Rennes], Département de médecine générale [Univ. Lorraine], Université de Lorraine (UL), Service d'endocrinologie-métabolisme [CHU Pitié-Salpêtrière], Assistance publique - Hôpitaux de Paris (AP-HP) (APHP)-CHU Pitié-Salpêtrière [APHP], Hôpital de la Timone [CHU - APHM] (TIMONE), Service de médecine interne [Nantes], Université de Nantes (UN)-Hôtel-Dieu-Centre hospitalier universitaire de Nantes (CHU Nantes), Service de cardiologie, Centre Hospitalier de la Basse Terre, CIC 501, Centre d’Investigation Clinique (CIC), Service de Pharmacologie Clinique, Centre Hospitalier Régional Universitaire de Tours (CHRU Tours)-Hôpital Bretonneau-Centre Hospitalier Régional Universitaire de Tours (CHRU TOURS), Equipe 3: EREN- Equipe de Recherche en Epidémiologie Nutritionnelle (CRESS - U1153), Université Paris 13 (UP13)-Institut National de la Recherche Agronomique (INRA)-Conservatoire National des Arts et Métiers [CNAM] (CNAM)-Centre de Recherche Épidémiologie et Statistique Sorbonne Paris Cité (CRESS (U1153 / UMR_A_1125 / UMR_S_1153)), Université Paris Diderot - Paris 7 (UPD7)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de la Recherche Agronomique (INRA)-Université Paris Descartes - Paris 5 (UPD5)-Université Sorbonne Paris Cité (USPC)-Université Paris Diderot - Paris 7 (UPD7)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de la Recherche Agronomique (INRA)-Université Paris Descartes - Paris 5 (UPD5)-Université Sorbonne Paris Cité (USPC), Université de Bordeaux (UB), Centre Hospitalier Emile Muller [Mulhouse] (CH E.Muller Mulhouse), Groupe Hospitalier de Territoire Haute Alsace (GHTHA), Hôpital Saint-André, Service de Néphrologie [Rouen], Université de Rouen Normandie (UNIROUEN), Normandie Université (NU)-Normandie Université (NU)-CHU Rouen, Normandie Université (NU), Endothélium, valvulopathies et insuffisance cardiaque (EnVI), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Rouen Normandie (UNIROUEN), Normandie Université (NU)-Normandie Université (NU), unité de recherche de l'institut du thorax UMR1087 UMR6291 (ITX), Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université de Nantes - UFR de Médecine et des Techniques Médicales (UFR MEDECINE), Université de Nantes (UN)-Université de Nantes (UN), Service de cardiologie [CHU de Poitiers], Centre hospitalier universitaire de Poitiers (CHU Poitiers), Institut français de l'Education (IFÉ), École normale supérieure - Lyon (ENS Lyon), Hôpital cardiologique, Université de Lille, Droit et Santé-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), Hôpital avicenne, Université Paris 13 (UP13)-Assistance publique - Hôpitaux de Paris (AP-HP) (APHP)-Hôpital Avicenne, Clinique Cardiologie et Hypertension Artérielle, Université Joseph Fourier - Grenoble 1 (UJF)-CHU Grenoble-Hôpital Michallon, Institut des Maladies Métaboliques et Cardiovasculaires (I2MC), Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National de la Santé et de la Recherche Médicale (INSERM), Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), Laboratoire 'Mobilité, Vieillissement, Exercice' (MOVE) (MOVE), Université de Poitiers, Cabinet médical, Centre d'Investigations Préventives et Cliniques (CIPC), Assistance publique - Hôpitaux de Paris (AP-HP) (APHP)-hôpital Jean-Verdier, Department of Cardiology, Erasme University Hospital, Paris-Centre de Recherche Cardiovasculaire (PARCC - UMR-S U970), Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Hôpital Européen Georges Pompidou [APHP] (HEGP), Assistance publique - Hôpitaux de Paris (AP-HP) (APHP)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO)-Assistance publique - Hôpitaux de Paris (AP-HP) (APHP)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO), Service de cardiologie et maladies vasculaires [Rennes] = Cardiac, Thoracic, and Vascular Surgery [Rennes], Société française d’hypertension artérielle (SFHTA), Service d’Endocrinologie, Métabolisme et Prévention des Risques Cardio-Vasculaires [CHU Pitié-Salpêtrière], CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), CHU Clermont-Ferrand, Université de Tours (UT), Université Paris Diderot - Paris 7 (UPD7)-Université Sorbonne Paris Cité (USPC)-Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de la Recherche Agronomique (INRA)-Université Paris Diderot - Paris 7 (UPD7)-Université Sorbonne Paris Cité (USPC)-Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de la Recherche Agronomique (INRA), Centre hospitalier de Haguenau, CHU Rouen, Normandie Université (NU)-Normandie Université (NU)-Université de Rouen Normandie (UNIROUEN), Normandie Université (NU)-Normandie Université (NU)-Institut National de la Santé et de la Recherche Médicale (INSERM), Université de Sfax - University of Sfax, Université de Nantes - UFR de Médecine et des Techniques Médicales (UFR MEDECINE), Université de Nantes (UN)-Université de Nantes (UN)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Hôpital Avicenne [AP-HP], Cliniques Universitaires Saint-Luc [Bruxelles], Hôpital Erasme [Bruxelles] (ULB), Faculté de Médecine [Bruxelles] (ULB), Université libre de Bruxelles (ULB)-Université libre de Bruxelles (ULB), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO), AP-HP - Hôpital Bichat - Claude Bernard [Paris], Université de Tours, Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées, Hôpital Européen Georges Pompidou [APHP] (HEGP), and Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO)-Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM)

Subjects
Consensus, Time Factors, Hypertension, Humans, Blood Pressure Determination, France, Blood Pressure Monitoring, Ambulatory, Societies, Medical, [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology
Abstract

International audience; Since 2016, the French Society of Hypertension has warned about the decline in the management of high blood pressure in France: stagnation, or even decreased number of people who know their blood pressure level, take a treatment and are controlled. These results are lower than those observed in many other countries. Blood pressure is measured with an old method in the doctor's office. Accepted, simple and cost-effective, this method is currently unavoidable for reasons of feasibility and social habit. It has been used in observational and intervention studies that are the basis of the medical reasoning for screening, treatment and drug control of hypertension. In practice, it is too often poorly applied and unpredictable. It is now necessary to measure blood pressure in mmHg using a validated oscillometric automatic device coupled to a specific upper arm cuff adapted to the arm circumferences for the diagnosis and monitoring of high blood pressure in the doctor's office and at home. The auscultatoric measurement is only recommended if any doubt about the reliability of the electronic measurement. Blood pressure measurement is basically performed on both arms to detect asymmetry and then on the arm with the highest blood pressure. It is performed in sitting or lying position after a few minutes of rest without speaking and without having smoked and then in standing position to diagnose orthostatic hypotension, especially in elderly, diabetic and multi-medicated subjects. The blood pressure measurement during the consultation must be repeated and include at least 3 consecutive measurements at one minute intervals. The average of the last 2 measurements determines the blood pressure level. It is recommended to perform BP measurements outside the medical environment for the diagnosis and monitoring of hypertension; Home BP measurement is preferred to ambulatory blood pressure measurement for practical reasons unless otherwise specified. The home blood pressure measurement should include three measurements in the morning at breakfast and three measurements in the evening before bedtime at one minute intervals for at least three days. Prior training must be provided. In treated hypertensive patients, a masked hypertension should be considered as an uncontrolled hypertension and antihypertensive therapy adapted accordingly. The measurement of central BP pressure (aorta) should be limited to clinical research.

Published
2019
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30. Recommandations sur la mesure de la pression artérielle. Consensus d’experts de la Société française d’hypertension artérielle, filiale de la Société française de cardiologie

Author

Denolle, Thierry, primary, Asmar, Roland, additional, Boivin, Jean-Marc, additional, Girerd, Xavier, additional, Le Jeune, Sylvain, additional, Vaisse, Bernard, additional, Antakly-Hanon, Yara, additional, Artifoni, Mathieu, additional, Atallah, André, additional, Bachelet, Christophe, additional, Barber-Chamoux, Nicolas, additional, Bejan-Angoulvant, Theodora, additional, Blacher, Jacques, additional, Boulestreau, Romain, additional, Chantrel, François, additional, Dimitrov, Yves, additional, Doll, Gérard, additional, Dugelay, Giselle, additional, Duly-Bouhanick, Béatrice, additional, Gosse, Philippe, additional, Guerrot, Dominique, additional, Jarraya, Faiçal, additional, Lamirault, Guillaume, additional, Lequeux, Benoit, additional, Lopez-Sublet, Marilucy, additional, Mercier, Alain, additional, Millet, Laurène, additional, Mounier-Véhier, Claire, additional, Mourad, Jean-Jacques, additional, Nasr, Edgar, additional, Ormezzano, Olivier, additional, Perez, Laurence, additional, Persu, Alexandre, additional, Ribstein, Jean, additional, Silhol, François, additional, Sosner, Philippe, additional, Steyer, Elisabeth, additional, Temmar, Mohamed, additional, Van De Borne, Philippe, additional, and Vidal-Petiot, Emmanuelle, additional

Published
2019
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31. Abdominal Aortic Calcifications Influences the Systemic and Renal Hemodynamic Response to Renal Denervation in the DENERHTN (Renal Denervation for Hypertension) Trial

Author

Pereira, Helena, Del Giudice, Costantino, Dourmap, Caroline, Azarine, Arshid, Azizi, Michel, Amar, L., Lorthioir, A., Monge, Matthieu, Pagny, J.‐Y., Claisse, G., Delsart, Pascal, Midulla, M., Mounier‐Vehier, Claire, Courand, Pierre-Yves, Dauphin, R., Fauvel, J., Lantelme, Pierre, Rouvière, O., CREMER, A., Gosse, Philippe, Grenier, N., Lebras, Y., Trillaud, H., Denolle, Thierry, Dourmap‐Collas, C., Heautot, J., Larralde, A., Paillard, F., Cluzel, P., Girerd, Xavier, Rosenbaum, D., Alison, D., Claudon, M., Popovic, B., Rossignol, Patrick, Ormezzano, Olivier, Thony, F., Bartoli, J., Vaisse, Bernard, Drouineau, J., Herpin, Daniel, Sosner, P., Tasu, J., Velasco, S., Ribstein, Jean, Bouhanick, Beatrice, Chamontin, B., Rousseau, H., Le Jeune, S., Lopez‐Sublet, M., Mourad, Jean‐Jacques, Bellmann, L., Esnault, V., Ferrari, Emile, Sapoval, Marc, Bobrie, Guillaume, Chatellier, Gilles, Plouin, P., Zannad, Faiez, Halimi, Jean Michel, Baguet, J., Kovacsik, H., Durand‐Zaleski, I., Beregi, J., Lièvre, M., Persu, A., Université Claude Bernard Lyon 1 (UCBL), and Université de Lyon

Subjects
[SDV]Life Sciences [q-bio], ComputingMilieux_MISCELLANEOUS
Abstract

International audience

Published
2017
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32. High Prevalence of Multiple Arterial Bed Lesions in Patients With Fibromuscular DysplasiaNovelty and Significance : The ARCADIA Registry (Assessment of Renal and Cervical Artery Dysplasia)

Author

Plouin, Pierre-François, Baguet, Jean-Philippe, Thony, Frédéric, Ormezzano, Olivier, Azarine, Arshid, Silhol, François, Oppenheim, Catherine, Bouhanick, Béatrice, Boyer, Louis, Persu, Alexandre, Hammer, Frank, Gosse, Philippe, Mounier-Vehier, Claire, Le Hello, Claire, Jeunemaitre, Xavier, Azizi, Michel, Amar, Laurence, Chatellier, Gilles, Mousseaux, Elie, Touzé, Emmanuel, UCL - SSS/IREC/CARD - Pôle de recherche cardiovasculaire, UCL - (SLuc) Service de pathologie cardiovasculaire, UCL - SSS/IREC/IMAG - Pôle d'imagerie médicale, UCL - (SLuc) Service de radiologie, and UCL - SSS/IONS/NEUR - Clinical Neuroscience

Subjects
Internal Medicine
Abstract

Fibromuscular dysplasia (FMD) commonly affects the renal and cervical arteries but has been described to affect other vascular beds as well. The prevalence of and clinical characteristics associated with multisite FMD (string-of-beds or focal stenoses affecting at least 2 vascular beds) are not known. In the prospective ARCADIA registry (Assessment of Renal and Cervical Artery Dysplasia), symptomatic patients with renal artery (RA) FMD underwent tomographic- or magnetic resonance-angiography from the aortic arch to the intracranial arteries and those with cervical FMD from the diaphragm to the pelvis. Of 469 patients (84.0% women), 225 (48.0%) had multisite FMD. In addition, 86 of 244 patients with single-site disease had dissections or aneurisms affecting other vascular beds, totaling 311 patients (66.3%) with lesions in >1 vascular bed. Among patients with a cerebrovascular presentation, the prevalence of RA lesions was higher in patients with than in those without hypertension (odds ratio, 3.4; 95% confidence interval, 1.99-6.15). Among patients with a renal presentation, the prevalence of cervical lesions was higher in patients with bilateral than in those with unilateral RA lesions (odds ratio, 1.9; 95% confidence interval, 0.99-3.57). In conclusion, FMD is a systemic arterial disease. At least 2 vascular beds were affected by dysplastic stenoses in 48.0% of cases and by dysplastic stenoses, aneurysms, and dissections in 66.1% of cases. RA imaging should be proposed to hypertensive patients with a cerebrovascular presentation. Cervical artery imaging should be considered in patients with a renal presentation and bilateral RA lesions. CLINICAL TRIAL REGISTRATION: URL: www.Clinicaltrials.gov. Unique identifier: NCT02884141.

Published
2017

33. How can cortisol-normalized adrenal venous sampling miss some Conn's adenoma

Author

Duparc, Elea, primary, Constantinescu, Georgiana, additional, Ormezzano, Olivier, additional, Thony, Frederic, additional, Rodiere, Mathieu, additional, Baguet, Jean-Philippe, additional, Gomez-Sanchez, Celsio, additional, Fernandes-Rosa, Fabio, additional, Sturm, Nathalie, additional, Chaffanjon, Philippe, additional, and Chabre, Olivier, additional

Published
2018
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34. High Prevalence of Multiple Arterial Bed Lesions in Patients With Fibromuscular DysplasiaNovelty and Significance : The ARCADIA Registry (Assessment of Renal and Cervical Artery Dysplasia)

Author

UCL - SSS/IREC/CARD - Pôle de recherche cardiovasculaire, UCL - (SLuc) Service de pathologie cardiovasculaire, UCL - SSS/IREC/IMAG - Pôle d'imagerie médicale, UCL - (SLuc) Service de radiologie, UCL - SSS/IONS/NEUR - Clinical Neuroscience, Plouin, Pierre-François, Baguet, Jean-Philippe, Thony, Frédéric, Ormezzano, Olivier, Azarine, Arshid, Silhol, François, Oppenheim, Catherine, Bouhanick, Béatrice, Boyer, Louis, Persu, Alexandre, Hammer, Frank, Gosse, Philippe, Mounier-Vehier, Claire, Le Hello, Claire, Jeunemaitre, Xavier, Azizi, Michel, Amar, Laurence, Chatellier, Gilles, Mousseaux, Elie, Touzé, Emmanuel, UCL - SSS/IREC/CARD - Pôle de recherche cardiovasculaire, UCL - (SLuc) Service de pathologie cardiovasculaire, UCL - SSS/IREC/IMAG - Pôle d'imagerie médicale, UCL - (SLuc) Service de radiologie, UCL - SSS/IONS/NEUR - Clinical Neuroscience, Plouin, Pierre-François, Baguet, Jean-Philippe, Thony, Frédéric, Ormezzano, Olivier, Azarine, Arshid, Silhol, François, Oppenheim, Catherine, Bouhanick, Béatrice, Boyer, Louis, Persu, Alexandre, Hammer, Frank, Gosse, Philippe, Mounier-Vehier, Claire, Le Hello, Claire, Jeunemaitre, Xavier, Azizi, Michel, Amar, Laurence, Chatellier, Gilles, Mousseaux, Elie, and Touzé, Emmanuel

Abstract

Fibromuscular dysplasia (FMD) commonly affects the renal and cervical arteries but has been described to affect other vascular beds as well. The prevalence of and clinical characteristics associated with multisite FMD (string-of-beds or focal stenoses affecting at least 2 vascular beds) are not known. In the prospective ARCADIA registry (Assessment of Renal and Cervical Artery Dysplasia), symptomatic patients with renal artery (RA) FMD underwent tomographic- or magnetic resonance-angiography from the aortic arch to the intracranial arteries and those with cervical FMD from the diaphragm to the pelvis. Of 469 patients (84.0% women), 225 (48.0%) had multisite FMD. In addition, 86 of 244 patients with single-site disease had dissections or aneurisms affecting other vascular beds, totaling 311 patients (66.3%) with lesions in >1 vascular bed. Among patients with a cerebrovascular presentation, the prevalence of RA lesions was higher in patients with than in those without hypertension (odds ratio, 3.4; 95% confidence interval, 1.99-6.15). Among patients with a renal presentation, the prevalence of cervical lesions was higher in patients with bilateral than in those with unilateral RA lesions (odds ratio, 1.9; 95% confidence interval, 0.99-3.57). In conclusion, FMD is a systemic arterial disease. At least 2 vascular beds were affected by dysplastic stenoses in 48.0% of cases and by dysplastic stenoses, aneurysms, and dissections in 66.1% of cases. RA imaging should be proposed to hypertensive patients with a cerebrovascular presentation. Cervical artery imaging should be considered in patients with a renal presentation and bilateral RA lesions. CLINICAL TRIAL REGISTRATION: URL: www.Clinicaltrials.gov. Unique identifier: NCT02884141.

Published
2017

35. Adherence to Antihypertensive Treatment and the Blood Pressure–Lowering Effects of Renal Denervation in the Renal Denervation for Hypertension (DENERHTN) TrialClinical Perspective

Author

Azizi, Michel, Pereira, Helena, Hamdidouche, Idir, Gosse, Philippe, Monge, Matthieu, Bobrie, Guillaume, Delsart, Pascal, Mounier-Vehier, Claire, Courand, Pierre-Yves, Lantelme, Pierre, Denolle, Thierry, Dourmap-Collas, Caroline, Girerd, Xavier, Michel Halimi, Jean, Zannad, Faiez, Ormezzano, Olivier, Vaisse, Bernard, Herpin, Daniel, Ribstein, Jean, Chamontin, Bernard, Mourad, Jean-Jacques, Ferrari, Emile, Plouin, Pierre-Francois, Jullien, Vincent, Sapoval, Marc, Chatellier, Gilles, Investigators, DENERHTN, Université Paris Descartes - Paris 5 (UPD5), Service de médecine vasculaire et hypertension artérielle [CHU HEGP], Hôpital Européen Georges Pompidou [APHP] (HEGP), Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO)-Assistance publique - Hôpitaux de Paris (AP-HP) (APHP)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO)-Assistance publique - Hôpitaux de Paris (AP-HP) (APHP), CIC - HEGP (CIC 1418), Assistance publique - Hôpitaux de Paris (AP-HP) (APHP)-Hôpital Européen Georges Pompidou [APHP] (HEGP), Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO)-Assistance publique - Hôpitaux de Paris (AP-HP) (APHP)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO)-Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM), Service d’Épidémiologie et de Recherche Clinique [CHU HEGP], Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO)-Assistance publique - Hôpitaux de Paris (AP-HP) (APHP)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO), Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO)-Assistance publique - Hôpitaux de Paris (AP-HP) (APHP), Hôpital Saint-André, Institut Mutualiste de Montsouris (IMM), Hôpital cardiologique, Université de Lille, Droit et Santé-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), Hôpital de la Croix-Rousse [CHU - HCL], Hospices Civils de Lyon (HCL), Centre de Recherche en Acquisition et Traitement de l'Image pour la Santé (CREATIS), Université Jean Monnet [Saint-Étienne] (UJM)-Hospices Civils de Lyon (HCL)-Institut National des Sciences Appliquées de Lyon (INSA Lyon), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Université de Lyon-Institut National des Sciences Appliquées (INSA)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM), Service de cardiologie et maladies vasculaires [CHU de Rennes], CHU Pontchaillou [Rennes], CHU Pitié-Salpêtrière [APHP], Hôpital Bretonneau, Centre Hospitalier Régional Universitaire de Tours (CHRU Tours), Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy), CHU Grenoble, Hôpital de la Timone [CHU - APHM] (TIMONE), Service de cardiologie [CHU de Poitiers], Centre hospitalier universitaire de Poitiers (CHU Poitiers), Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), CHU Toulouse [Toulouse], Hôpital avicenne, Université Paris 13 (UP13)-Assistance publique - Hôpitaux de Paris (AP-HP) (APHP)-Hôpital Avicenne, Centre Hospitalier Universitaire de Nice (CHU Nice), Epilepsies de l'Enfant et Plasticité Cérébrale (U1129), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Européen Georges Pompidou [APHP] (HEGP), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO), Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Européen Georges Pompidou [APHP] (HEGP), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO), Service de cardiologie et maladies vasculaires [Rennes] = Cardiac, Thoracic, and Vascular Surgery [Rennes], CHU Pitié-Salpêtrière [AP-HP], Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Hôpital Avicenne [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO)-Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National des Sciences Appliquées de Lyon (INSA Lyon), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Université Jean Monnet - Saint-Étienne (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Centre Hospitalier Universitaire de Toulouse (CHU Toulouse), and Institut National des Sciences Appliquées (INSA)-Université de Lyon-Institut National des Sciences Appliquées (INSA)-Université de Lyon-Université Claude Bernard Lyon 1 (UCBL)

Subjects
sympathetic nervous system, kidney, hypertension, medications, [SDV.MHEP.CSC]Life Sciences [q-bio]/Human health and pathology/Cardiology and cardiovascular system, nervous system, ablation techniques
Abstract

International audience; BACKGROUND:The DENERHTN trial (Renal Denervation for Hypertension) confirmed the blood pressure-lowering efficacy of renal denervation added to a standardized stepped-care antihypertensive treatment for resistant hypertension at 6 months. We report the influence of adherence to antihypertensive treatment on blood pressure control.METHODS:One hundred six patients with hypertension resistant to 4 weeks of treatment with indapamide 1.5 mg/d, ramipril 10 mg/d (or irbesartan 300 mg/d), and amlodipine 10 mg/d were randomly assigned to renal denervation plus standardized stepped-care antihypertensive treatment, or the same antihypertensive treatment alone. For standardized stepped-care antihypertensive treatment, spironolactone 25 mg/d, bisoprolol 10 mg/d, prazosin 5 mg/d, and rilmenidine 1 mg/d were sequentially added at monthly visits if home blood pressure was ≥135/85 mm Hg after randomization. We assessed adherence to antihypertensive treatment at 6 months by drug screening in urine/plasma samples from 85 patients.RESULTS:The numbers of fully adherent (20/40 versus 21/45), partially nonadherent (13/40 versus 20/45), or completely nonadherent patients (7/40 versus 4/45) to antihypertensive treatment were not different in the renal denervation and the control groups, respectively (P=0.3605). The difference in the change in daytime ambulatory systolic blood pressure from baseline to 6 months between the 2 groups was -6.7 mm Hg (P=0.0461) in fully adherent and -7.8 mm Hg (P=0.0996) in nonadherent (partially nonadherent plus completely nonadherent) patients. The between-patient variability of daytime ambulatory systolic blood pressure was greater for nonadherent than for fully adherent patients.CONCLUSIONS:In the DENERHTN trial, the prevalence of nonadherence to antihypertensive drugs at 6 months was high (≈50%) but not different in the renal denervation and control groups. Regardless of adherence to treatment, renal denervation plus standardized stepped-care antihypertensive treatment resulted in a greater decrease in blood pressure than standardized stepped-care antihypertensive treatment alone.CLINICAL TRIAL REGISTRATION:URL: http://www.clinicaltrials.gov. Unique identifier: NCT01570777.

Published
2016
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36. Abdominal Aortic Calcifications Influences the Systemic and Renal Hemodynamic Response to Renal Denervation in the DENERHTN (Renal Denervation for Hypertension) Trial

Author

Courand, Pierre‐Yves, primary, Pereira, Helena, additional, Del Giudice, Costantino, additional, Gosse, Philippe, additional, Monge, Matthieu, additional, Bobrie, Guillaume, additional, Delsart, Pascal, additional, Mounier‐Vehier, Claire, additional, Lantelme, Pierre, additional, Denolle, Thierry, additional, Dourmap, Caroline, additional, Halimi, Jean Michel, additional, Girerd, Xavier, additional, Rossignol, Patrick, additional, Zannad, Faiez, additional, Ormezzano, Olivier, additional, Vaisse, Bernard, additional, Herpin, Daniel, additional, Ribstein, Jean, additional, Bouhanick, Beatrice, additional, Mourad, Jean‐Jacques, additional, Ferrari, Emile, additional, Chatellier, Gilles, additional, Sapoval, Marc, additional, Azarine, Arshid, additional, Azizi, Michel, additional, Amar, L., additional, Bobrie, G., additional, Lorthioir, A., additional, Monge, M., additional, Pagny, J.‐Y., additional, Plouin, P. F., additional, Sapoval, M., additional, Claisse, G., additional, Delsart, P., additional, Midulla, M., additional, Mounier‐Vehier, C., additional, Courand, P. Y., additional, Dauphin, R., additional, Fauvel, J. P., additional, Lantelme, P., additional, Rouvière, O., additional, Cremer, A., additional, Gosse, P., additional, Grenier, N., additional, Lebras, Y., additional, Trillaud, H., additional, Denolle, T., additional, Dourmap‐Collas, C., additional, Heautot, J. F., additional, Larralde, A., additional, Paillard, F., additional, Cluzel, P., additional, Girerd, X., additional, Rosenbaum, D., additional, Alison, D., additional, Halimi, J. M., additional, Claudon, M., additional, Popovic, B., additional, Rossignol, P., additional, Zannad, F., additional, Baguet, J. P., additional, Ormezzano, O., additional, Thony, F., additional, Bartoli, J. M., additional, Vaïsse, B., additional, Drouineau, J., additional, Herpin, D., additional, Sosner, P., additional, Tasu, J. P., additional, Velasco, S., additional, Ribstein, J., additional, Kovacsik, H., additional, Bouhanick, B., additional, Chamontin, B., additional, Rousseau, H., additional, Le Jeune, S., additional, Lopez‐Sublet, M., additional, Mourad, J. J., additional, Bellmann, L., additional, Esnault, V., additional, Ferrari, E., additional, Chatellier, G., additional, Durand‐Zaleski, I., additional, Beregi, J. P., additional, Lièvre, M., additional, and Persu, A., additional

Published
2017
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37. Left ventricular remodeling and epicardial fat volume in obese patients with severe obstructive sleep apnea treated by continuous positive airway pressure

Author

Barone-Rochette, Gilles, primary, Vivodtzev, Isabelle, additional, Tamisier, Renaud, additional, Rodière, Mathieu, additional, Ormezzano, Olivier, additional, Baguet, Jean Philippe, additional, Grangier, Angélique, additional, Wuyam, Bernard, additional, Levy, Patrick, additional, and Pépin, Jean Louis, additional

Published
2015
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39. Influence des facteurs génétiques et du stress oxydatif sur les variations du baroréflexe chez les sujets sains et les patients hypertendus

Author

Ormezzano, Olivier and UL, Thèses

Subjects
[SDV.MHEP] Life Sciences [q-bio]/Human health and pathology, Stress oxydatif, Baroréflexes, Génétique, Hypertension artérielle
Abstract

Non disponible / Not available, Chez 120 sujets sains et 163 hypertendus jamais traités, les inter-relations entre la sensibilité du baroréflexe, le stress oxydatif (isoprostanes urinaires) et 17 polymorphismes de gènes participant au système cardiovasculaire, ont été étudiées. La sensibilité du baroréflexe est en partie génétiquement déterminée, ainsi le polymorphisme C+1222T du gène du récepteur A à l'endothéline a été retrouvé associé au baroréflexe de façon indépendante de la pression artérielle. Le niveau de stress oxydatif n'a pas été retrouvé augmenté chez les patients présentant une hypertension artérielle essentielle par rapport aux normotendus. Dans ces deux groupes de patients, la sensibilité du baroréflexe n'est pas liée au niveau de stress oxydatif. Le stress oxydatif semble être influencé par certains gènes du système rénine angiotensine et en particulier a été retrouvé lié avec le polymorphisme AGTR1/A-153G du gène du récepteur I à l'angiotensine Il.

Published
2005

41. Impact of telmisartan in modifying vascular risk

Author

Baguet,Jean-Philippe, Ormezzano,Olivier, Barone-Rochette,Gilles, Baguet,Jean-Philippe, Ormezzano,Olivier, and Barone-Rochette,Gilles

Abstract

Jean-Philippe Baguet, Olivier Ormezzano, Gilles Barone-RochetteClinique de Cardiologie, Centre Hospitalier Universitaire de Grenoble, Grenoble, FranceAbstract: Telmisartan, a selective angiotensin II type 1 receptor blocker (ARB), has been investigated in many trials, in particular, in order to assess its antihypertensive effect in various situations and its ability to protect organs susceptible to hypertension. In addition to its antihypertensive properties, it has positive metabolic and vascular effects (partly because of its sustained action). Several large-scale trials have focused on the effect of telmisartan on cardiovascular morbidity and mortality, including comparisons of that with an angiotens-inconverting enzyme inhibitor in subjects at high vascular risk. Telmisartan was used in the largest ARB research programme (the Ongoing Telmisartan Alone and in Combination with Ramipril Global Endpoint Trial [ONTARGET] and Telmisartan Randomized Assessment Study in ACE Intolerant Subjects with Cardiovascular Disease [TRANSCEND] trial).Keywords: angiotensin II receptor blocker cardiovascular risk, hypertension, blood pressure, renin–angiotensin–aldosterone system

Published
2010

42. Early cardiovascular abnormalities in newly diagnosed obstructive sleep apnea

Author

Baguet,Jean-Philippe, Nadra,Marie, Barone-Rochette,Gilles, Ormezzano,Olivier, Pierre,Hélène, Pépin,Jean-Louis, Baguet,Jean-Philippe, Nadra,Marie, Barone-Rochette,Gilles, Ormezzano,Olivier, Pierre,Hélène, and Pépin,Jean-Louis

Abstract

Jean-Philippe Baguet1, Marie Nadra1, Gilles Barone-Rochette1, Olivier Ormezzano1, Hélène Pierre1, Jean-Louis Pépin21Department of Cardiology, University Hospital, Grenoble, France; 2Sleep Laboratory, EFCR, University Hospital, Grenoble, FranceAbstract: Obstructive sleep apnea (OSA) is associated with high cardiovascular morbidity and mortality. Recent studies have shown that it is associated with atherosclerosis and left ventricular dysfunction markers. The aim of this study was to assess the cardiovascular effects of OSA depending on its severity, in patients without clinically diagnosed cardiovascular disease. One hundred thirty newly diagnosed, nondiabetic OSA patients (mean age 49 ± 10 years), without vasoactive treatment were included. They underwent clinical and ambulatory blood pressure measurements, echocardiography, carotid ultrasound examination, and a carotid–femoral pulse wave velocity (PWV) measurement. Seventy-five percent of the subjects were hypertensive according to the clinical or ambulatory measurement. More patients with the most severe forms (respiratory disturbance index >37/hour) had a nondipper profile (52% vs 34%; P = 0.025) and their left ventricular mass was higher (40 ± 7 vs 36 ± 8 g/m, p = 0.014). This last parameter was independently and inversely associated with mean nocturnal oxygen saturation (P = 0.004). PWV and carotid intima-media thickness did not differ between one OSA severity group to another, but the prevalence of carotid hypertrophy was higher when mean SaO2 was below 93.5% (29.5 vs 16%; P = 0.05). Our study shows that in OSA patients without clinically diagnosed cardiovascular disease, there is a significant left ventricular and arterial effect, which is even more marked when OSA is severe.Keywords: obstructive sleep apnea, hypertension, left ventricular hypertrophy, intima-media thickness, arterial stiffness

Published
2009

43. Blood pressure remains too high after a type A aortic dissection or haematoma

Author

Baguet, Jean-Philippe, primary, Boggetto-Graham, Laetitia, additional, Thony, Frdric, additional, Barone-Rochette, Gilles, additional, Rodire, Mathieu, additional, Ppin, Jean-Louis, additional, Pierre, Hlne, additional, Baguet, Sverine, additional, Ormezzano, Olivier, additional, Vautrin, Estelle, additional, and Chavanon, Olivier, additional

Published
2012
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