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2 results on '"Orkhan Karımov"'

1. Assessment of factors related to statin non-adherence in patients with established coronary artery disease: A single-center observational study

Author

Tuba Özdemir, İrfan Şahin, İlhan İlker Avcı, Barış Güngör, Eser Durmaz, Sevil Tuğrul, Mert İlker Hayıroğlu, Serdar Kahyaoğlu, Orkhan Karımov, and Ertuğrul Okuyan

Subjects
adherence, coronary artery disease, statin., Medicine, Internal medicine, RC31-1245, Diseases of the circulatory (Cardiovascular) system, RC666-701
Abstract

Objective: Lifelong statin treatment is recommended in patients with cardiovascular diseases, but drug adherence is a significant problem. The aim of this study was to investigate factors related to statin discontinuation in high-risk patients with coronary artery disease (CAD) diagnosed by coronary angiography. Methods: A total of 300 consecutive patients who were followed-up with a diagnosis of CAD were recruited. Patients were categorized as statin adherent or statin non-adherent (patients interrupting statin therapy >30 days). Study participants completed a questionnaire regarding demographic characteristics, medical history, knowledge of statin treatment, and factors related to statin discontinuation. Results: In all, 160 patients (53.3%) were found to be statin adherent. Of those, 122 patients had suffered myocardial infarction, and atorvastatin was the most prescribed statin on discharge. Among the study population, 26% were illiterate and 55% had graduated from primary school. Only 39 cases (13%) cases had a low-density lipoprotein-cholesterol level

Published
2017
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2. Prognostic Significance of Fragmented QRS in Patients with Acute Ischemic Stroke

Author

Ramazan Asoğlu, Adem Atici, Ertugrul Okuyan, Irfan Sahin, Hasan Ali Barman, Orkhan Karımov, Sevgi Özcan, Didem Celik, Nilufer Kale, and Sevil Tugrul

Subjects
Male, medicine.medical_specialty, Time Factors, Fragmented qrs, Action Potentials, QT interval, Risk Assessment, QRS complex, Electrocardiography, Heart Conduction System, Heart Rate, Predictive Value of Tests, Risk Factors, Internal medicine, Medicine, Humans, cardiovascular diseases, PR interval, Aged, Ischemic Stroke, Retrospective Studies, ST depression, Aged, 80 and over, medicine.diagnostic_test, business.industry, Proportional hazards model, Rehabilitation, Hazard ratio, Magnetic resonance imaging, Arrhythmias, Cardiac, Middle Aged, Prognosis, Diffusion Magnetic Resonance Imaging, Cardiology, Surgery, Female, Neurology (clinical), medicine.symptom, Cardiology and Cardiovascular Medicine, business, Tomography, X-Ray Computed
Abstract

There are studies in the literature showing the clinical importance of fragmented QRS (fQRS) in many systemic diseases. In this study, we aimed to investigate the frequency and prognostic value of fQRS on electrocardiogram (ECG) in patients with acute ischemic stroke.We prospectively enrolled 241 patients with acute ischemic stroke between January 2018 and January 2020. ST depression and elevation, QRS duration, PR interval, RR interval, QTc interval, QTc dispersion (QTcd), T negativity, Q wave, and fQRS were evaluated on ECG. Brain computed tomography (CT) and diffusion magnetic resonance imaging (MRI) images were obtained in the acute period and the National Institute of Health Stroke Scale (NIHSS) score was calculated for each patient. Patients were followed up for a period of two years.The 241 patients comprised 121 (50.2%) men and 120 (49.8%) women with a mean age of 67.52 ± 13.00 years. In Cox regression analysis, age, NIHSS, QTcd, and fQRS were found to be independent predictors of mortality (age, hazard ratio [HR]: 1.063, p 0.001; NIHSS, HR: 1.116, p = 0.006; QTcd, HR: 1.029, p = 0.042; fQRS, HR: 2.048, p = 0.037). Two-year mortality was higher in patients with fQRS than in patients without fQRS (31% vs. 9%, p = 0.001).The fQRS is associated with poor prognosis in patients with acute ischemic stroke.

Published
2021

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