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589 results on '"Orita Y"'

13. Does HMGB1 predict occult neck lymph node metastasis in early tongue carcinoma? A case–control study of 26 patients

Author

Hanakawa, H, primary, Orita, Y, additional, Sato, Y, additional, Takeuchi, M, additional, Takao, S, additional, Ohno, K, additional, Kohno, T, additional, Iwaki, N, additional, Marunaka, H, additional, Tamamura, R, additional, Nishibori, M, additional, Nagatsuka, H, additional, Nishizaki, K, additional, and Yoshino, T, additional

Published
2014
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22. In Vivo Transfection of Genes for Renin and Angiotensinogen into the Glomerular Cells Induced Phenotypic Change of the Mesangial Cells and Glomerular Sclerosis

Author

Arai, M., primary, Wada, A., additional, Isaka, Y., additional, Akagi, Y., additional, Sugiura, T., additional, Miyazaki, M., additional, Moriyama, T., additional, Kaneda, Y., additional, Naruse, K., additional, Naruse, M., additional, Orita, Y., additional, Ando, A., additional, Kamada, T., additional, Ueda, N., additional, and Imai, E., additional

Published
1995
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38. Two-dimensional echocardiographic demonstration of so-called aneurysm of the membranous ventricular septum in adults. Value of combined 'manual scanning'

Author

Maruoka Y, Okamatsu S, Motoomi Nakamura, Tsuneo Hirata, Yutaka Kikuchi, Senichi Tanaka, and Orita Y

Subjects
Adult, Heart Septal Defects, Ventricular, Male, medicine.medical_specialty, Short axis, Adolescent, Physiology, Electrocardiography, Aneurysm, Internal medicine, medicine, Humans, Heart Aneurysm, Left sternal border, Long axis, business.industry, Middle Aged, medicine.disease, medicine.anatomical_structure, Echocardiography, Ventricle, Parasternal line, Cardiology, Female, Cardiology and Cardiovascular Medicine, business
Abstract

Using two-dimensional (2-D) echocardiography we evaluated the applicability of the left ventricular (LV) short axis view combined with manual scanning technique for the detection and evaluation of aneurysms of the membranous ventricular septum (AMS). In 12 patients with angiographically proven AMS, we recorded from the left sternal border the short axis view of the left ventricle continuously displayed from the aortic to the ventricular level by tilting the transducer manually along the LV long axis plane. We then compared the detectability of AMS by this method with that by other standard fixed 2-D echocardiographic views. This method proved to be best for the detection of AMS (12/12), followed by an apical four-chamber view (10/12), a parasternal LV long axis view (8/12) and an apical two-chamber (2/12) view. For the detection of AMS and for three-dimensional evaluation of the structure of the AMS and the original orifice of ventricular septal defect the method was shown to be clinically applicable.

Published
1983

39. Apoptosis induced by hypertonicity in Madin Darley canine kidney cells: protective effect of betaine.

Author

Horio, M, Ito, A, Matsuoka, Y, Moriyama, T, Orita, Y, Takenaka, M, and Imai, E

Abstract

In mammals, the renal medulla is in a hypertonic environment related to the renal concentrating mechanism. Renal cells accumulate osmolytes such as betaine to protect cells from the perturbing effect of high concentration of electrolytes. Hypertonicity-induced cell death and the effect of betaine were investigated in Madin Darby canine kidney (MDCK) cells.

Published
2001
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43. Aquaretic effect of a potent, orally active, nonpeptide V2 antagonist in men.

Author

Ohnishi, A, Orita, Y, Takagi, N, Fujita, T, Toyoki, T, Ihara, Y, Yamamura, Y, Inoue, T, and Tanaka, T

Abstract

Solute-free water diuretics (aquaretics) that antagonize hydrosmotic vasopressin 2 (V2) receptors may be useful in treating diseases in which water is retained. An orally active, nonpeptide, selective V2 antagonist (OPC-31260) was administered in six dose steps (3, 15, 30, 60, 100 and 200 mg) to six healthy, normally hydrated men to investigate the aquaretic effects in comparison with 12 placebo-treated control subjects (two at each dose). All subjects tolerated all six doses without serious clinical side effects. OPC-31260 increased the first 6-hr hypotonic urine volume dose-dependently. Administration at 30 mg raised the 6-hr urine volume to 2 times, 100 mg to 3 times and 200 mg to 4 times (1828.0 +/- 130.2 ml/6 hr) that of the placebo group (470.4 +/- 52.1 ml/6 hr). The drug increased urine flow maximally between 1 and 1.5 hr at all doses (e.g., 10.0 +/- 0.7-10.8 +/- 0.4 ml/min at 60-200 mg). The drug rapidly lowered urine osmolality for 4 hr, particularly between 60 and 90 min (e.g., 72.3 +/- 2.3 and 62.3 +/- 5.1 mOsm/kg at 100 and 200 mg, respectively). In marked hypotonic diuresis, mean free-water clearance of the 6-hr urine increased dose-proportionally into the positive range, reaching 2.82 +/- 0.21 ml/min at 200 mg.(ABSTRACT TRUNCATED AT 250 WORDS)

Published
1995

45. In VivoTransfection of Genes for Renin and Angiotensinogen into the Glomerular Cells Induced Phenotypic Change of the Mesangial Cells and Glomerular Sclerosis

Author

Arai, M., Wada, A., Isaka, Y., Akagi, Y., Sugiura, T., Miyazaki, M., Moriyama, T., Kaneda, Y., Naruse, K., Naruse, M., Orita, Y., Ando, A., Kamada, T., Ueda, N., and Imai, E.

Abstract

Locally activated renin angiotensin system plays an important role in the progression of the glomerular diseases. In order to understand the local effect of overexpressed angiotensin II in the glomerulus in situ, we introduced human genes for renin and angiotensinogen into the rat kidney by hemagglutinating virus of Japan-liposome procedure. Three days after transfection human renin was detected in the glomeruli by immunohistochemistry. Seven days after transfection, extracellular matrix was expanded in the glomeruli and α-smooth muscle actin was expressed in the mesangial cells. These results suggest that locally activated renin angiotensin system induces glomerular sclerosis and a phenotypic change in mesangial cells.

Published
1995
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47. Interaction of calcium and microtubules in the action of cyclic AMP on the toad urinary bladder.

Author

Yuasa, S, Takamitsu, Y, Miki, S, Orita, Y, Abe, H, and Watanabe, T

Abstract

Involvement of microtubules in the cellular action of vasopressin was studied by physiological and biochemical procedures. The inhibitory effect of 10(-4) M colchicine on the hydro-osmotic response of the toad bladder to 2 mM cyclic AMP was completely blocked by an increase in the concentration of calcium in the serosal bathing medium from 1 to 8 mM. Most of the colchicine-binding activity of extracts of the bladder epithelial cells was recovered by DEAE-Sephadex chromatography in a procedure similar to that used to isolate tubulin of bovine brain. Sodium dodecyl sulfate urea and urea gel electrophoresis of the DEAE-Sephadex fraction from the bladder epithelial cells yielded bands that corresponded to those of bovine brain tubulin. When 8 mM CaCl2 was present in an incubation mixture, the binding of colchicine to tubulin from the bladder epithelial cells and bovine brain was significantly inhibited. However, 1 mM CaCl2 did not affect the binding of colchicine to tubulin. Although the present study supports the concept that microtubules and calcium play an important role in the cellular action of vasopressin on the toad urinary bladder, the mechanism by which calcium blocks the inhibitory effect of colchicine on the hydro-osmotic response to cyclic AMP could not be elucidated.

Published
1980

49. Medial high jugular bulb.

Author

Haginomori, Shin-Ichi, Sando, Isamu, Miura, Makoto, Orita, Yorihisa, Hirsch, Barry E., Haginomori, S, Sando, I, Miura, M, Orita, Y, and Hirsch, B E

Published
2001
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50. Laser photolysis and fluorescence studies on pyrene-thiazide and pyrene-diazoxide systems

Author

Orita Y, Ando A, Hiroshi Masuhara, Mataga N, and Urakabe S

Subjects
Structure-Activity Relationship, Hydrochlorothiazide, Photolysis, Pyrenes, Lasers, Sodium Chloride Symporter Inhibitors, Diazoxide, Diuretics, Fluorescence
Abstract

The laser photolysis studies on pyrene, pyrene-thiazides and pyrene-diazoxide systems in acetonitrile revealed that thiazides and diazoxide can scavenge the photoejected electron. It was found that the pyrene fluorescence is quenched by the present diuretics and related compounds and both static and dynamic quenching constants were obtained. Thiazides quench the fluorescence through both static and dynamic mechanism, while the small static quenching constant and no lifetime shortening of pyrene were observed in the case of diazoxide quencher. This difference may correspond to the difference of their diuretic activity.

Published
1977

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