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4. Colposcopy Accuracy and Diagnostic Performance: A Quality Control and Quality Assurance Survey in Italian Tertiary-Level Teaching and Academic Institutions—The Italian Society of Colposcopy and Cervico-Vaginal Pathology (SICPCV)

Author

Origoni, Massimo, primary, Cantatore, Francesco, additional, Sopracordevole, Francesco, additional, Clemente, Nicolò, additional, Spinillo, Arsenio, additional, Gardella, Barbara, additional, De Vincenzo, Rosa, additional, Ricci, Caterina, additional, Landoni, Fabio, additional, Di Meo, Maria Letizia, additional, Ciavattini, Andrea, additional, Di Giuseppe, Jacopo, additional, Preti, Eleonora, additional, Iacobone, Anna Daniela, additional, Carriero, Carmine, additional, Dellino, Miriam, additional, Capodanno, Massimo, additional, Perino, Antonino, additional, Miglioli, Cesare, additional, Insolia, Luca, additional, Barbero, Maggiorino, additional, and Candiani, Massimo, additional

Published
2023
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5. In Situ/Microinvasive Adenocarcinoma of the Uterine Cervix and HPV-Type Impact: Pathologic Features, Treatment Options, and Follow-Up Outcomes—Cervical Adenocarcinoma Study Group (CAS-Group)

Author

Giannella, Luca, primary, Delli Carpini, Giovanni, additional, Di Giuseppe, Jacopo, additional, Bogani, Giorgio, additional, Sopracordevole, Francesco, additional, Clemente, Nicolò, additional, Giorda, Giorgio, additional, De Vincenzo, Rosa Pasqualina, additional, Evangelista, Maria Teresa, additional, Gardella, Barbara, additional, Dominoni, Mattia, additional, Monti, Ermelinda, additional, Alessi, Chiara, additional, Alessandrini, Lara, additional, Pagan, Alessio, additional, Caretto, Marta, additional, Ghelardi, Alessandro, additional, Amadori, Andrea, additional, Origoni, Massimo, additional, Barbero, Maggiorino, additional, Raspagliesi, Francesco, additional, Simoncini, Tommaso, additional, Vercellini, Paolo, additional, Scambia, Giovanni, additional, and Ciavattini, Andrea, additional

Published
2023
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6. Monitoring the activities of Italian colposcopy clinics before and during the COVID-19 pandemic

Author

Delli Carpini, Giovanni, Giorgi Rossi, Paolo, Giannella, Luca, Di Giuseppe, Jacopo, Clemente, Nicolò, Sopracordevole, Francesco, Barbero, Maggiorino, Bogani, Giorgio, De Vincenzo, Rosa Pasqualina, Origoni, Massimo, Cantatore, Francesco, Gardella, Barbara, Dominoni, Mattia, Monti, Ermelinda, Liverani, Carlo Antonio, Viscardi, Anna, Pagan, Alessio, Amadori, Andrea, Alessi, Chiara, Andolfatto, Matteo, Cattani, Paolo, Pieralli, Annalisa, Stevenazzi, Guido, Ciavattini, Andrea, De Vincenzo, Rosa (ORCID:0000-0001-7408-0435), Delli Carpini, Giovanni, Giorgi Rossi, Paolo, Giannella, Luca, Di Giuseppe, Jacopo, Clemente, Nicolò, Sopracordevole, Francesco, Barbero, Maggiorino, Bogani, Giorgio, De Vincenzo, Rosa Pasqualina, Origoni, Massimo, Cantatore, Francesco, Gardella, Barbara, Dominoni, Mattia, Monti, Ermelinda, Liverani, Carlo Antonio, Viscardi, Anna, Pagan, Alessio, Amadori, Andrea, Alessi, Chiara, Andolfatto, Matteo, Cattani, Paolo, Pieralli, Annalisa, Stevenazzi, Guido, Ciavattini, Andrea, and De Vincenzo, Rosa (ORCID:0000-0001-7408-0435)

Abstract

Objective: To evaluate the impact of healthcare reorganization during the severe acute respiratory syndrome coronavirus 2 pandemic on Italian colposcopy clinic activities, focusing on cervical excision procedures, follow-ups for conservative management of low-grade lesions, and follow-ups post cervical excision.Methods: Retrospective study conducted in 14 Italian colposcopy clinics. The number and clinical characteristics of cervical excisions, follow-ups for conservative management of low-grade lesions, and follow-ups after cervical excision were compared between the period March 1, 2019 to February 29, 2020 (pre-pandemic) and March 1, 2020 to February 28, 2021 (pandemic) with a Poisson regression analysis.Results: In the pandemic period, the number of cervical excisions was reduced by 8.8% (95% confidence interval [CI]=-15.6% to -2%; p=0.011). Excisions were less frequently performed in the operating room (-35.1%; 95% CI=-47.6% to -22.6%; p<0.001), the number of patients from spontaneous screening was reduced by -14.0% (95% CI=-23.4% to -4.6%; p=0.003), and the CO2-laser technique was used less frequently (-30%; 95% CI=-45.1% to -15.0%; p<0.001). As compared to the pre-pandemic period, the number of follow-ups for conservative management of low-grade lesions was reduced by -26.7% (95% CI=-39.0% to -14.4%; p<0.001), and the follow-up appointments after cervical excision were reduced by -51.0% (95% CI=-58.1% to -43.9%; p<0.001).Conclusion: The most significant impact of the healthcare reorganization during the coronavirus disease 2019 pandemic was on follow-ups after cervical excision. The resumption of disrupted activities should follow a risk-based prioritization, starting from women in follow-up after cervical excision. It is advisable that the trend of performing cervical excision as an outpatient procedure is maintained in the post-pandemic period.

Published
2023

9. Monitoring the activities of Italian colposcopy clinics before and during the COVID-19 pandemic

Author

Delli Carpini, Giovanni, primary, Giorgi Rossi, Paolo, additional, Giannella, Luca, additional, Di Giuseppe, Jacopo, additional, Clemente, Nicolò, additional, Sopracordevole, Francesco, additional, Barbero, Maggiorino, additional, Bogani, Giorgio, additional, De Vincenzo, Rosa, additional, Origoni, Massimo, additional, Cantatore, Francesco, additional, Gardella, Barbara, additional, Dominoni, Mattia, additional, Monti, Ermelinda, additional, Liverani, Carlo Antonio, additional, Viscardi, Anna, additional, Pagan, Alessio, additional, Amadori, Andrea, additional, Alessi, Chiara, additional, Andolfatto, Matteo, additional, Cattani, Paolo, additional, Pieralli, Annalisa, additional, Stevenazzi, Guido, additional, and Ciavattini, Andrea, additional

Published
2022
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10. Monitoring the activities of Italian colposcopy clinics before and during the COVID-19 pandemic.

Author

Carpini, Giovanni Delli, Rossi, Paolo Giorgi, Giannella, Luca, Di Giuseppe, Jacopo, Clemente, Nicolò, Sopracordevole, Francesco, Barbero, Maggiorino, Bogani, Giorgio, De Vincenzo, Rosa, Origoni, Massimo, Cantatore, Francesco, Gardella, Barbara, Dominoni, Mattia, Monti, Ermelinda, Liverani, Carlo Antonio, Viscardi, Anna, Pagan, Alessio, Amadori, Andrea, Alessi, Chiara, and Andolfatto, Matteo

Subjects
COLPOSCOPY, SARS-CoV-2, COVID-19 pandemic
Abstract

Objective: To evaluate the impact of healthcare reorganization during the severe acute respiratory syndrome coronavirus 2 pandemic on Italian colposcopy clinic activities, focusing on cervical excision procedures, follow-ups for conservative management of low-grade lesions, and follow-ups post cervical excision. Methods: Retrospective study conducted in 14 Italian colposcopy clinics. The number and clinical characteristics of cervical excisions, follow-ups for conservative management of low-grade lesions, and follow-ups after cervical excision were compared between the period March 1, 2019 to February 29, 2020 (pre-pandemic) and March 1, 2020 to February 28, 2021 (pandemic) with a Poisson regression analysis. Results: In the pandemic period, the number of cervical excisions was reduced by 8.8% (95% confidence interval [CI]=-15.6% to -2%; p=0.011). Excisions were less frequently performed in the operating room (-35.1%; 95% CI=-47.6% to -22.6%; p<0.001), the number of patients from spontaneous screening was reduced by -14.0% (95% CI=-23.4% to -4.6%; p=0.003), and the CO2-laser technique was used less frequently (-30%; 95% CI=-45.1% to -15.0%; p<0.001). As compared to the pre-pandemic period, the number of follow-ups for conservative management of low-grade lesions was reduced by -26.7% (95% CI=-39.0% to -14.4%; p<0.001), and the follow-up appointments after cervical excision were reduced by -51.0% (95% CI=-58.1% to -43.9%; p<0.001). Conclusion: The most significant impact of the healthcare reorganization during the coronavirus disease 2019 pandemic was on follow-ups after cervical excision. The resumption of disrupted activities should follow a risk-based prioritization, starting from women in follow-up after cervical excision. It is advisable that the trend of performing cervical excision as an outpatient procedure is maintained in the post-pandemic period. [ABSTRACT FROM AUTHOR]

Published
2023
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16. [HPV vaccination: not only female adolescents and not only prophylactic. Review and position paper of the Italian HPV Study Group (IHSG)]

Author

Origoni, Massimo, Cristoforoni, Paolo, Mariani, Luciano, Costa, Silvano, Preti, Mario, Sandri, Maria T, Preti, Eleonora P, Ghelardi, Alessandro, Perino, Antonio, Origoni, Massimo, Cristoforoni, Paolo, Mariani, Luciano, Costa, Silvano, Preti, Mario, Sandri, Maria T, Preti, Eleonora P, Ghelardi, Alessandro, and Perino, Antonio

Subjects
Adult, Male, HPV, Adolescent, Italy, Papillomavirus Infections, Vaccination, Age Factors, Humans, Uterine Cervical Neoplasms, Female, Papillomavirus Vaccines
Abstract

HPV vaccination has been introduced in clinical practice in recent years and represents the most effective strategy of primary prevention of cervical carcinoma and of female genital preneoplastic conditions. One of the major issues of the subject is represented by vaccination coverage of the target population. Since its introduction, HPV vaccine efficacy has been progressively demonstrated also towards extragenital HPV-correlated conditions and in males too. Moreover, even subjects of older age groups or subjects who already had HPV infections have been demonstrated to received benefits from vaccination, due to improvements of their immunological response. Recently, vaccine efficacy has also been investigated in terms of adjuvant administration after treatments of preneoplastic or benign conditions of the female lower genital tract caused by HPVs; preliminary results indicate an interesting and promising field of application. On this basis, in this article an analysis of the state of the art has been performed, with specific regard to the Italian scenario and with the focus of future perspectives of implementation of the HPV vaccination policy. From the available evidences, the Italian HPV Study Group recommends the extension of systematic HPV vaccination to males too, to adult subjects and also after conservative treatment of genital HPV correlated conditions.

Published
2019

17. Immunogenicity and safety of a nine-valent human papillomavirus vaccine in women 27–45 years of age compared to women 16–26 years of age: An open-label phase 3 study

Author

Joura, Elmar A., primary, Ulied, Angels, additional, Vandermeulen, Corinne, additional, Rua Figueroa, Milagrosa, additional, Seppä, Ilkka, additional, Hernandez Aguado, Juan José, additional, Ahonen, Anitta, additional, Reich, Olaf, additional, Virta, Miia, additional, Perino, Antonino, additional, Peris Tuser, Merce, additional, Peters, Klaus, additional, Origoni, Massimo, additional, Raspagliesi, Francesco, additional, Tjalma, Wiebren A.A., additional, Tummers, Philippe, additional, Woelber, Linn, additional, Nieminen, Pekka, additional, van Damme, Pierre, additional, Sehouli, Jalid, additional, Fiol Ruiz, Gabriel, additional, Brucker, Sara, additional, Fehm, Tanja, additional, Cheon, Kyeongmi, additional, Rawat, Sonali, additional, Luxembourg, Alain, additional, and Wittke, Frederick, additional

Published
2021
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18. MSJ952310_supplementary_1 – Supplemental material for Vaccinations in patients with multiple sclerosis: A Delphi consensus statement

Author

Riva, Agostino, Barcella, Valeria, Benatti, Simone V, Capobianco, Marco, Capra, Ruggero, Cinque, Paola, Comi, Giancarlo, Fasolo, Maria Michela, Franzetti, Fabio, Galli, Massimo, Gerevini, Simonetta, Meroni, Luca, Origoni, Massimo, Prosperini, Luca, Puoti, Massimo, Scarpazza, Cristina, Tortorella, Carla, Zaffaroni, Mauro, and Moiola, Lucia

Subjects
FOS: Clinical medicine, 111702 Aged Health Care, FOS: Health sciences, 110904 Neurology and Neuromuscular Diseases
Abstract

Supplemental material, MSJ952310_supplementary_1 for Vaccinations in patients with multiple sclerosis: A Delphi consensus statement by Agostino Riva, Valeria Barcella, Simone V Benatti, Marco Capobianco, Ruggero Capra, Paola Cinque, Giancarlo Comi, Maria Michela Fasolo, Fabio Franzetti, Massimo Galli, Simonetta Gerevini, Luca Meroni, Massimo Origoni, Luca Prosperini, Massimo Puoti, Cristina Scarpazza, Carla Tortorella, Mauro Zaffaroni and Lucia Moiola in Multiple Sclerosis Journal

Published
2020
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19. Vaccinations in patients with multiple sclerosis: A Delphi consensus statement

Author

Riva, Agostino, primary, Barcella, Valeria, additional, Benatti, Simone V, additional, Capobianco, Marco, additional, Capra, Ruggero, additional, Cinque, Paola, additional, Comi, Giancarlo, additional, Fasolo, Maria Michela, additional, Franzetti, Fabio, additional, Galli, Massimo, additional, Gerevini, Simonetta, additional, Meroni, Luca, additional, Origoni, Massimo, additional, Prosperini, Luca, additional, Puoti, Massimo, additional, Scarpazza, Cristina, additional, Tortorella, Carla, additional, Zaffaroni, Mauro, additional, and Moiola, Lucia, additional

Published
2020
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20. The risk of infection in patients with multiple sclerosis treated with disease-modifying therapies: A Delphi consensus statement

Author

Moiola, Lucia, primary, Barcella, Valeria, additional, Benatti, Simone, additional, Capobianco, Marco, additional, Capra, Ruggero, additional, Cinque, Paola, additional, Comi, Giancarlo, additional, Fasolo, Maria Michela, additional, Franzetti, Fabio, additional, Galli, Massimo, additional, Gerevini, Simonetta, additional, Meroni, Luca, additional, Origoni, Massimo, additional, Prosperini, Luca, additional, Puoti, Massimo, additional, Scarpazza, Cristina, additional, Tortorella, Carla, additional, Zaffaroni, Mauro, additional, and Riva, Agostino, additional

Published
2020
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22. The risk of infection in patients with multiple sclerosis treated with disease-modifying therapies: A Delphi consensus statement.

Author

Moiola, Lucia, Barcella, Valeria, Benatti, Simone, Capobianco, Marco, Capra, Ruggero, Cinque, Paola, Comi, Giancarlo, Fasolo, Maria Michela, Franzetti, Fabio, Galli, Massimo, Gerevini, Simonetta, Meroni, Luca, Origoni, Massimo, Prosperini, Luca, Puoti, Massimo, Scarpazza, Cristina, Tortorella, Carla, Zaffaroni, Mauro, and Riva, Agostino

Subjects
AIDS-related opportunistic infections, URINARY tract infections, RESPIRATORY infections, PROGRESSIVE multifocal leukoencephalopathy, MULTIPLE sclerosis, OPPORTUNISTIC infections
Abstract

The risk of infection associated with immunomodulatory or immunosuppressive disease-modifying drugs (DMDs) in patients with multiple sclerosis (MS) has been increasingly addressed in recent scientific literature. A modified Delphi consensus process was conducted to develop clinically relevant, evidence-based recommendations to assist physicians with decision-making in relation to the risks of a wide range of infections associated with different DMDs in patients with MS. The current consensus statements, developed by a panel of experts (neurologists, infectious disease specialists, a gynaecologist and a neuroradiologist), address the risk of iatrogenic infections (opportunistic infections, including herpes and cryptococcal infections, candidiasis and listeria; progressive multifocal leukoencephalopathy; human papillomavirus and urinary tract infections; respiratory tract infections and tuberculosis; hepatitis and gastrointestinal infections) in patients with MS treated with different DMDs, as well as prevention strategies and surveillance strategies for the early identification of infections. In the discussion, more recent data emerged in the literature were taken into consideration. Recommended risk reduction and management strategies for infections include screening at diagnosis and before starting a new DMD, prophylaxis where appropriate, monitoring and early diagnosis. [ABSTRACT FROM AUTHOR]

Published
2021
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23. Vaccinations in patients with multiple sclerosis: A Delphi consensus statement.

Author

Riva, Agostino, Barcella, Valeria, Benatti, Simone V, Capobianco, Marco, Capra, Ruggero, Cinque, Paola, Comi, Giancarlo, Fasolo, Maria Michela, Franzetti, Fabio, Galli, Massimo, Gerevini, Simonetta, Meroni, Luca, Origoni, Massimo, Prosperini, Luca, Puoti, Massimo, Scarpazza, Cristina, Tortorella, Carla, Zaffaroni, Mauro, and Moiola, Lucia

Subjects
MULTIPLE sclerosis, VACCINATION, SEASONAL influenza, INFLUENZA, COMMUNICABLE diseases
Abstract

Background: Patients with multiple sclerosis (MS) are at increased risk of infection. Vaccination can mitigate these risks but only if safe and effective in MS patients, including those taking disease-modifying drugs. Methods: A modified Delphi consensus process (October 2017–June 2018) was used to develop clinically relevant recommendations for making decisions about vaccinations in patients with MS. A series of statements and recommendations regarding the efficacy, safety and timing of vaccine administration in patients with MS were generated in April 2018 by a panel of experts based on a review of the published literature performed in October 2017. Results: Recommendations include the need for an 'infectious diseases card' of each patient's infectious and immunisation history at diagnosis in order to exclude and eventually treat latent infections. We suggest the implementation of the locally recommended vaccinations, if possible at MS diagnosis, otherwise with vaccination timing tailored to the planned/current MS treatment, and yearly administration of the seasonal influenza vaccine regardless of the treatment received. Conclusion: Patients with MS should be vaccinated with careful consideration of risks and benefits. However, there is an urgent need for more research into vaccinations in patients with MS to guide evidence-based decision making. [ABSTRACT FROM AUTHOR]

Published
2021
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24. VIN usual type - From the past to the future

Author

Preti M, Igidbashian S, Costa S, Cristoforoni P, Mariani L, Sandri MT, Boveri F, Spolti N, Spinaci L, Sanvito F, Preti EP, Falasca A, Radici G, Micheletti L., ORIGONI , MASSIMO, Preti, M, Igidbashian, S, Costa, S, Cristoforoni, P, Mariani, L, Origoni, Massimo, Sandri, Mt, Boveri, F, Spolti, N, Spinaci, L, Sanvito, F, Preti, Ep, Falasca, A, Radici, G, and Micheletti, L.

Published
2015

32. Small Cell Carcinoma of the Ovary: Report of Three Cases of a Poor Prognosis Disease

Author

ORIGONI , MASSIMO, Bergamini A, Pella F, Ottolina J, Giorgione V, Del Prato D, Almirante G, CANDIANI , MASSIMO, Origoni, Massimo, Bergamini, A, Pella, F, Ottolina, J, Giorgione, V, Del Prato, D, Almirante, G, and Candiani, Massimo

Subjects
Pathology, medicine.medical_specialty, Poor prognosis, medicine.anatomical_structure, business.industry, medicine, Ovary, Disease, medicine.disease, business, Small-cell carcinoma
Published
2013

33. Lichen sclerosus of the vulva

Author

ORIGONI , MASSIMO, Gelardi C, Salvatore S, CANDIANI , MASSIMO, Origoni, Massimo, Gelardi, C, Salvatore, S, and Candiani, Massimo

Published
2013

38. Productive HIV-1 infection in cervical tissue ex vivo

Author

Saba E, Ferrari D, Taccagni G, Doglioni C, Lisco A, Margolis L, POLI, GUIDO, ORIGONI , MASSIMO, Saba, E, Ferrari, D, Origoni, Massimo, Taccagni, G, Doglioni, C, Lisco, A, Margolis, L, and Poli, Guido

Published
2012

40. Urogynecological Conditions

Author

Salvatore S, Redaelli A, Parma M, Quaranta L, Candiani M., ORIGONI , MASSIMO, Salvatore, S, Redaelli, A, Parma, M, Quaranta, L, Origoni, Massimo, and Candiani, M.

Published
2012

43. Is overactive bladder in children and adults the same condition?: ICI-RS 2011

Author

SALVATORE , STEFANO, Serati M, ORIGONI , MASSIMO, CANDIANI , MASSIMO, Salvatore, Stefano, Serati, M, Origoni, Massimo, and Candiani, Massimo

Abstract

Aim To report the debate on the relationship between overactive bladder (OAB) in children and adults during the ICI-RS meeting in 2010. Methods: Literature supporting or being against the theory that OAB in children and adults represents the same condition has been reviewed and debated. Results: Growing evidence is showing a strong link between urinary symptoms in childhood, such as nocturnal enuresis (NE) and OAB symptoms, and OAB in adulthood. Behavioral and environmental factors may have an important role in predisposed subjects. Studies on familial and genetic factors have been reported. Conclusion: It might be inappropriate to state that OAB in children and adults represents the same condition. However, epidemiological and genetic findings demonstrate a strong link between OAB symptoms in these two different ages of life. Predisposing factors and behavioral and/or environmental elements may lead to OAB occurrence in adults. Neurourol. Urodynam. 31:349-351, 2012. (C) 2012 Wiley Periodicals, Inc.

Published
2012

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