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1. L. S. Stavrianos, The Balkans since 1453, Hold Rinehart and Winston, 3. baskı, New York 1961, 970 sayfa. [Kitap Tanıtımı]

Author

Orhan F. Köprülü

Subjects
History of Civilization, CB3-482
Abstract

Eserinin basıldığı sıralarda Northwestern Üniversitesi'nde tarih profesörü olan L. S. Stavrianos'un ilk defa 1958'de yayınlanmış olan bu monografisi o dönemde Amerika'da büyük bir ün kazanmıştı. Piyasaya çıkması, Columbia Üniversitesi'nde research associate olarak çalıştığım yıllara rastlayan bu kitabı o zamanlar ancak şöylece karıştırmıştım. 1961 - 1962 ders yılında ise İndiana Üniversitesi'nde doktora öğrencilerine Asociate Professor sıfatıyla Osmanlı tarihi okuttuğum devrede ise adı geçen kitabı daha yakından incelemek fırsatını bulmuştum. Rum asıllı bir Amerikalı tarih profesörünün büyük bir tarafsızlıkla kaleme aldığı ve derin bir araştırma mahsûlü olan kitap, Osmanlı tarihi bakımından da birinci elden bilgileri ele aldığı cihetle üzerinde durulmağa değer kıymetli bir çalışma idi.

Published
1993
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2. DANIEL PANZAC, La Peste Dans L'Empire Ottoman, 1700-1850, Collection Turcica, Editions Peeters 1985, Leuven, Belgique, 659 sayfa. [Kitap Tanıtımı]

Author

Orhan F. Köprülü

Subjects
History of Civilization, CB3-482
Abstract

Bundan 17 yıl önce yazdığım bir makalede (Türkler ve Türkiye hakkında bilinmeyen veya az bilinen İngilizce Kaynaklar, Cumhuriyetin 50. yılına Armağan, TKAE, Ankara 1973, s. 170), Dr. Willam Mac Michael'in Journey from Moscou to Constantinople in the years 1817, 1818 (London 1818) adını taşıyan ve tarihçilerimizce hiç kullanılmamış olan seyahatnamesinden söz ederken, William Mac Michael'ın journey from Moscou to Constontinople in the years 1817, 1818 (London 1818) adını taşıyan ve tarihçilerimizce hiç kullanılmamış olan seyahatnamesinden söz ederken, William Mac Michael'ın 1815'te İstanbul Yedikule'deki Rum hastahanesinde çalışmış olan Dr. Charles Maclean'in Results of an investigation respecting epidemic and pestilential diseases including researches in the Levant concerning the Plague (Londres 1817 - 1818) adını taşıyan iki ciltlik kitabından geniş nakillerde bulunduğunu, burada ileri sürdüğü iddiaların mübalegalı olmakla birlikte, üzerinde durulması gerektiğini belirtmiştim. Bildiğim kadarıyla Osmanlı İmparatorluğu'nda vebanın oynadığı menfi rol üzerinde ilk ciddi eser Dr. Charles Maclean'ın yukarıda adını verdiğimiz eseri olup, yine bir az önce işaret ettiğim üzre, bu kitaptaki bazı bilgi ve iddiaları seyahatnamesine aktaran Dr. Mac Michael da bu hususta dikkate değer görüşler ileri sürmüştür. Aradan uzun yıllar geçtikten sonra L.S. Stavrianos The Balkans Since 1453 (Newyork 1958) adlı eserinde Osmanlı İmparatorluğunun parçalanmasında, imparatorluğun hudutları içinde şiddetli hüküm süren vebanın büyük bir payı olduğunu iddia etmişti (Dr. Orhan F. Köprülü, ayn. mak. göst. yer). Son yıllarda ise Daniel Panzac, yukarıda adını verdiğimiz monografisi ile Osmanlı İmparatorluğu'nda veba hastalığını çok geniş bir şekilde ele alarak çok güzel bir eser ortaya koymuştur.

Published
1990
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3. FERİDUN M. EMECEN, XVI. Asırda Manisa Kazası, Türk Tarih Kurumu Yayınları, Ankara 1989, XXVI + 362 sayfa. [Kitap Tanıtımı]

Author

Orhan F. Köprülü

Subjects
History of Civilization, CB3-482
Abstract

[Doç.] Dr. Feridun M. Emecen'in Türk Tarih Kurumu yayınları arasında çıkan ve XVI. Asırda Manisa Kazası (Ankara 1989) adını taşıyan monografisi, çeşitli bakımlardan üzerinde durulması gereken bir eserdir. Yazar, ele aldığı konunun icâbı, her türlü belgeyi gözden geçirmeği ihmal etmemekle birlikte, Saruhan İli'nin yapısı hakkında en güvenilir bilgi ve ana kaynağı Tapu Tahrir Defteri'nin teşkil ettiğini söyleyerek, hareket noktasını doğru ve sağlam bir şekilde tespit etmiştir. Sayın Emecen, bu defterlerin nasıl tanzim edildiği hususunda gerekli malumâtı verdikten ve ilk tahrir defterlerinin bugün elde mevcut olmadığını belirttikten sonra, II. Bayezid devrindeki "Piyadegân Defteri" ile 1531 tarihli "Mufassal Defter" deki kayıtlardan faydalanarak, XVI. yüzyıldan önce Saruhan Sancağı'nın 5 defa tahriri yapıldığını ve ilk tahririn muhtemelen Hacı İvaz Bey tarafından gerçekleştirildiğini yazmaktadır. Müellif, bu zatın, Çelebi Mehmed ve II. Murad devri ümerasından olduğunu tahmin etmektedir. İkinci tahrir ise, Emecen'in hemen hemen kesin bir şekilde tespit ettiğine göre, II. Murad devri ümerasından Kassâb-oğlu tarafından gerçekleştirilmiştir. Yazar, sağlam karinelere dayanarak, elde bulunmayan diğer üç tahririn de yıllarını aşağı yukarı tespit etmeğe muvaffak olmuştur.

Published
1990
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4. Tarihte Türk-Amerikan Münasebetleri

Author

Orhan F. Köprülü

Subjects
History of Civilization, CB3-482
Abstract

Konumuza girmeden önce bir hususu çok kısa olarak burada belirtmek isterim. Böyle bir konferansta hemen hemen ikiyüz yıla yaklaşan Türk-Amerikan münasebetlerinin bütününü bir konuşmaya sığdırmanın imkânsızlığı karşısında, bugünkü konuşmamda bu münasebetlerin XIX. yüzyıldaki kısmına ağırlık vereceğimi, esasen daha sonraki münasebetler hakkında son yıllarda memleketimizde de bir takım çalışmalar yapıldığını hatırlatmak isterim.

Published
1987
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5. Osmanlı Tarihi'nin Yabancı Kaynaklarından: İngilizce Kaynaklar

Author

Orhan F. Köprülü

Subjects
History of Civilization, CB3-482
Abstract

Osmanlı Tarihi'nin yabancı kaynakları, bu imparatorluğun üç büyük kıtada yayılmış olması dolayısıyla, bugüne kadar gerek Türk, gerek yabancı tarihçilerce bilinen ve kullanıla gelmiş olanların çok ötesindedir. Biz burada Osmanlı Tarihi'nin çeşitli yabancı kaynaklarından sadece İngilizce yazılmış olanları üzerinde durmak istiyoruz. İngilizce yazılmış kaynaklar tabirini burada özellikle kullanıyoruz. Zira Osmanlı Tarihi'nin İngilizce yazılmış kaynakları demekle yalnız İngiliz veya Amerikalı yazarlar tarafından bu dilde yazılmış, yayımlanmış veya yazma olarak kalmış eserleri değil başka milletlere mensup kimselerce hatta Türk müelliflerce kaleme alınmış olan İngilizce kitap ve makaleleri de kastediyoruz. Ancak böyle bir makalede bu dilde yazılmış kaynak ve araştırmaların herbirinden ayrı ayrı bahsetmek, bunların mahiyet ve değerleri üzerinde fikir yürütmek mümkün değildir. Ancak ele alacağımız bazı eserler ve bunlarda verilen bilgiler hakkında yer yer yapacağımız mukayeseler, bahis konusu kaynakların nasıl ihmal edilmiş olduğunu açıkça gösterecektir. Sıkı bir tenkit süzgecinden geçirilmek şartıyla bu cins kitaplarda bulunan bilgilerin, layıkıyla değerlendirildiği takdirde Osmanlı Tarihi çalışmalarında nekadar yararlı olabileceğini çeşitli misallerle belirtmeye çalışacağız.

Published
1986
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6. Brain Age Prediction Reveals Aberrant Brain White Matter in Schizophrenia and Bipolar Disorder: A Multisample Diffusion Tensor Imaging Study

Author

Farde, L., Flyckt, L., Engberg, G., Erhardt, S., Fatouros-Bergman, H., Cervenka, S., Schwieler, L., Piehl, F., Agartz, I., Collste, K., Victorsson, P., Malmqvist, A., Hedberg, M., Orhan, F., Sellgren, C., Tønnesen, Siren, Kaufmann, Tobias, de Lange, Ann-Marie G., Richard, Geneviève, Doan, Nhat Trung, Alnæs, Dag, van der Meer, Dennis, Rokicki, Jaroslav, Moberget, Torgeir, Maximov, Ivan I., Agartz, Ingrid, Aminoff, Sofie R., Beck, Dani, Barch, Deanna M., Beresniewicz, Justyna, Cervenka, Simon, Fatouros-Bergman, Helena, Craven, Alexander R., Flyckt, Lena, Gurholt, Tiril P., Haukvik, Unn K., Hugdahl, Kenneth, Johnsen, Erik, Jönsson, Erik G., Kolskår, Knut K., Kroken, Rune Andreas, Lagerberg, Trine V., Løberg, Else-Marie, Nordvik, Jan Egil, Sanders, Anne-Marthe, Ulrichsen, Kristine, Andreassen, Ole A., and Westlye, Lars T.

Published
2020
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11. Reproducibility in the absence of selective reporting: An illustration from large‐scale brain asymmetry research

Author

Kong, X.Z., Francks, C., Mathias, S.R., Guadalupe, T.M., Abé, C., Agartz, I., Buitelaar, J.K., Luijten, M., Fisher, S.E., Orhan, F., Sellgren, C., Kong, X.Z., Francks, C., Mathias, S.R., Guadalupe, T.M., Abé, C., Agartz, I., Buitelaar, J.K., Luijten, M., Fisher, S.E., Orhan, F., and Sellgren, C.

Abstract

Contains fulltext : 227140.pdf (publisher's version ) (Open Access), The problem of poor reproducibility of scientific findings has received much attention over recent years, in a variety of fields including psychology and neuroscience. The problem has been partly attributed to publication bias and unwanted practices such as p-hacking. Low statistical power in individual studies is also understood to be an important factor. In a recent multisite collaborative study, we mapped brain anatomical left-right asymmetries for regional measures of surface area and cortical thickness, in 99 MRI datasets from around the world, for a total of over 17,000 participants. In the present study, we revisited these hemispheric effects from the perspective of reproducibility. Within each dataset, we considered that an effect had been reproduced when it matched the meta-analytic effect from the 98 other datasets, in terms of effect direction and significance threshold. In this sense, the results within each dataset were viewed as coming from separate studies in an "ideal publishing environment," that is, free from selective reporting and p hacking. We found an average reproducibility rate of 63.2% (SD = 22.9%, min = 22.2%, max = 97.0%). As expected, reproducibility was higher for larger effects and in larger datasets. Reproducibility was not obviously related to the age of participants, scanner field strength, FreeSurfer software version, cortical regional measurement reliability, or regional size. These findings constitute an empirical illustration of reproducibility in the absence of publication bias or p hacking, when assessing realistic biological effects in heterogeneous neuroscience data, and given typically-used sample sizes.

Published
2022

14. An adaptive smoothing method for sensor noise in augmented reality applications on smartphones

Author

Demirci, Muhammed Fatih, Abul, O., Özcan, R., Orhan, F., Demirci, Muhammed Fatih, Abul, O., Özcan, R., and Orhan, F.

Abstract

Handling inaccurate and noisy sensor readings are among important challenges while implementing augmented reality applications on smartphones. As a result, we need to smooth the sensor readings for steady operation. However, no smoothing algorithm performs best in all cases as there is an inherent tradeoff. On one hand, excessive smoothing slows down the effect of device movements, hence makes applications less responsive. On the other hand, insufficient smoothing causes objects on the screen to constantly move back and forth even while the device is steady, hence makes applications too responsive. Clearly, both of the extremes cause augmented reality applications to be less effective in terms of human-computer interaction performance. In this paper, we propose an adaptive smoothing method based on the rate of change in device view direction. Basically, the method adjusts the smoothing level adaptively based on the phone movement. Our experimental results show that our adaptive approach, in comparison to previous proposals, achieves a better smoothing for various cases of phone movements. © 2012 ICST Institute for Computer Science, Social Informatics and Telecommunications Engineering.

Published
2021

17. The genetic architecture of human brainstem structures and their involvement in common brain disorders

Author

Elvsåshagen, Torbjørn, Bahrami, Shahram, van der Meer, Dennis, Agartz, Ingrid, Alnæs, Dag, Barch, Deanna M., Baur-Streubel, Ramona, Bertolino, Alessandro, Beyer, Mona K., Blasi, Giuseppe, Borgwardt, Stefan, Boye, Birgitte, Buitelaar, Jan, Bøen, Erlend, Celius, Elisabeth Gulowsen, Cervenka, Simon, Conzelmann, Annette, Coynel, David, Di Carlo, Pasquale, Djurovic, Srdjan, Eisenacher, Sarah, Espeseth, Thomas, Fatouros-Bergman, Helena, Flyckt, Lena, Franke, Barbara, Frei, Oleksandr, Gelao, Barbara, Harbo, Hanne Flinstad, Hartman, Catharina A., Håberg, Asta, Heslenfeld, Dirk, Hoekstra, Pieter J., Høgestøl, Einar A., Jonassen, Rune, Jönsson, Erik G., Kirsch, Peter, Kłoszewska, Iwona, Lagerberg, Trine Vik, Landrø, Nils Inge, Le Hellard, Stephanie, Lesch, Klaus-Peter, Maglanoc, Luigi A., Malt, Ulrik F., Mecocci, Patrizia, Melle, Ingrid, Meyer-Lindenberg, Andreas, Moberget, Torgeir, Nordvik, Jan Egil, Nyberg, Lars, O'Connell, Kevin S., Oosterlaan, Jaap, Papalino, Marco, Papassotiropoulos, Andreas, Pauli, Paul, Pergola, Giulio, Persson, Karin, de Quervain, Dominique, Reif, Andreas, Rokicki, Jaroslav, van Rooij, Daan, Shadrin, Alexey A., Schmidt, André, Schwarz, Emanuel, Selbæk, Geir, Soininen, Hilkka, Sowa, Piotr, Steen, Vidar M., Tsolaki, Magda, Vellas, Bruno, Wang, Lei, Westman, Eric, Ziegler, Georg C., Zink, Mathias, Andreassen, Ole A., Westlye, Lars T., Kaufmann, Tobias, Farde, L., Flyckt, L., Engberg, G., Erhardt, S. S., Fatouros-Bergman, H., Cervenka, S., Schwieler, L., Piehl, F., Agartz, I, Collste, K., Victorsson, P., Malmqvist, A., Hedberg, M., Orhan, F., Sellgren, C. M., Elvsåshagen, Torbjørn, Bahrami, Shahram, van der Meer, Dennis, Agartz, Ingrid, Alnæs, Dag, Barch, Deanna M., Baur-Streubel, Ramona, Bertolino, Alessandro, Beyer, Mona K., Blasi, Giuseppe, Borgwardt, Stefan, Boye, Birgitte, Buitelaar, Jan, Bøen, Erlend, Celius, Elisabeth Gulowsen, Cervenka, Simon, Conzelmann, Annette, Coynel, David, Di Carlo, Pasquale, Djurovic, Srdjan, Eisenacher, Sarah, Espeseth, Thomas, Fatouros-Bergman, Helena, Flyckt, Lena, Franke, Barbara, Frei, Oleksandr, Gelao, Barbara, Harbo, Hanne Flinstad, Hartman, Catharina A., Håberg, Asta, Heslenfeld, Dirk, Hoekstra, Pieter J., Høgestøl, Einar A., Jonassen, Rune, Jönsson, Erik G., Kirsch, Peter, Kłoszewska, Iwona, Lagerberg, Trine Vik, Landrø, Nils Inge, Le Hellard, Stephanie, Lesch, Klaus-Peter, Maglanoc, Luigi A., Malt, Ulrik F., Mecocci, Patrizia, Melle, Ingrid, Meyer-Lindenberg, Andreas, Moberget, Torgeir, Nordvik, Jan Egil, Nyberg, Lars, O'Connell, Kevin S., Oosterlaan, Jaap, Papalino, Marco, Papassotiropoulos, Andreas, Pauli, Paul, Pergola, Giulio, Persson, Karin, de Quervain, Dominique, Reif, Andreas, Rokicki, Jaroslav, van Rooij, Daan, Shadrin, Alexey A., Schmidt, André, Schwarz, Emanuel, Selbæk, Geir, Soininen, Hilkka, Sowa, Piotr, Steen, Vidar M., Tsolaki, Magda, Vellas, Bruno, Wang, Lei, Westman, Eric, Ziegler, Georg C., Zink, Mathias, Andreassen, Ole A., Westlye, Lars T., Kaufmann, Tobias, Farde, L., Flyckt, L., Engberg, G., Erhardt, S. S., Fatouros-Bergman, H., Cervenka, S., Schwieler, L., Piehl, F., Agartz, I, Collste, K., Victorsson, P., Malmqvist, A., Hedberg, M., Orhan, F., and Sellgren, C. M.

Abstract

Brainstem regions support vital bodily functions, yet their genetic architectures and involvement in common brain disorders remain understudied. Here, using imaging-genetics data from a discovery sample of 27,034 individuals, we identify 45 brainstem-associated genetic loci, including the first linked to midbrain, pons, and medulla oblongata volumes, and map them to 305 genes. In a replication sample of 7432 participants most of the loci show the same effect direction and are significant at a nominal threshold. We detect genetic overlap between brainstem volumes and eight psychiatric and neurological disorders. In additional clinical data from 5062 individuals with common brain disorders and 11,257 healthy controls, we observe differential volume alterations in schizophrenia, bipolar disorder, multiple sclerosis, mild cognitive impairment, dementia, and Parkinson's disease, supporting the relevance of brainstem regions and their genetic architectures in common brain disorders. The genetic architecture underlying brainstem regions and how this links to common brain disorders is not well understood. Here, the authors use MRI and GWAS data from 27,034 individuals to identify genetic and morphological brainstem features that influence common brain disorders.

Published
2020
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20. Brain Age Prediction Reveals Aberrant Brain White Matter in Schizophrenia and Bipolar Disorder: A Multisample Diffusion Tensor Imaging Study

Author

Tønnesen, Siren, primary, Kaufmann, Tobias, additional, de Lange, Ann-Marie G., additional, Richard, Geneviève, additional, Doan, Nhat Trung, additional, Alnæs, Dag, additional, van der Meer, Dennis, additional, Rokicki, Jaroslav, additional, Moberget, Torgeir, additional, Maximov, Ivan I., additional, Agartz, Ingrid, additional, Aminoff, Sofie R., additional, Beck, Dani, additional, Barch, Deanna M., additional, Beresniewicz, Justyna, additional, Cervenka, Simon, additional, Fatouros-Bergman, Helena, additional, Craven, Alexander R., additional, Flyckt, Lena, additional, Gurholt, Tiril P., additional, Haukvik, Unn K., additional, Hugdahl, Kenneth, additional, Johnsen, Erik, additional, Jönsson, Erik G., additional, Kolskår, Knut K., additional, Kroken, Rune Andreas, additional, Lagerberg, Trine V., additional, Løberg, Else-Marie, additional, Nordvik, Jan Egil, additional, Sanders, Anne-Marthe, additional, Ulrichsen, Kristine, additional, Andreassen, Ole A., additional, Westlye, Lars T., additional, Farde, L., additional, Flyckt, L., additional, Engberg, G., additional, Erhardt, S., additional, Fatouros-Bergman, H., additional, Cervenka, S., additional, Schwieler, L., additional, Piehl, F., additional, Agartz, I., additional, Collste, K., additional, Victorsson, P., additional, Malmqvist, A., additional, Hedberg, M., additional, Orhan, F., additional, and Sellgren, C., additional

Published
2020
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23. Anaphylaxis: Turkish National Guideline 2018

Author

Orhan, F, Civelek, E, Sahiner, UM, Arga, M, Can, D, Calikaner, AZ, Yilmaz, O, Orhan, F, Civelek, E, Sahiner, UM, Arga, M, Can, D, Calikaner, AZ, Yilmaz, O, and Yeditepe Üniversitesi

Subjects
National guideline, Turkish National Society of Allergy and Clinical Immunology, Anaphylaxis
Abstract

Anaphylaxis is an acute and potentially fatal systemic reaction that sould be recognized and managed by all helthcare professionals. This is the first national guideline of Turkish National Society of Allergy and Clinical Immunology on diagnosis and management of anaphylaxis. The guideline is prepared by Anaphylaxis Interest Group with the incorporation of 20 allergy/immunology specialists and the epidemiology, etiology, pathophysiology, symptoms and signs, diagnosis/differentials, and acute and long-term management of anaphylaxis are reviewed in detail.

Published
2018

25. Common brain disorders are associated with heritable patterns of apparent aging of the brain

Author

Kaufmann, T., van der Meer, D., Doan, N. T., Schwarz, E., Lund, M. J., Agartz, I., Alnaes, D., Barch, D. M., Baur-Streubel, R., Bertolino, A., Bettella, F., Beyer, M. K., Boen, E., Borgwardt, S., Brandt, C. L., Buitelaar, J., Celius, E. G., Cervenka, S., Conzelmann, A., Cordova-Palomera, A., Dale, A. M., de Quervain, D. J. F., Carlo, P. D., Djurovic, S., Dorum, E. S., Eisenacher, S., Elvsashagen, T., Espeseth, T., Fatouros-Bergman, H., Flyckt, L., Franke, B., Frei, O., Haatveit, B., Haberg, A. K., Harbo, H. F., Hartman, C. A., Heslenfeld, D., Hoekstra, P. J., Hogestol, E. A., Jernigan, T. L., Jonassen, R., Jonsson, E. G., Farde, L., Engberg, G., Erhardt, S., Schwieler, L., Piehl, F., Collste, K., Victorsson, P., Malmqvist, A., Hedberg, M., Orhan, F., Kirsch, P., Kloszewska, I., Kolskar, K. K., Landro, N. I., Hellard, S. L., Lesch, K. -P., Lovestone, S., Lundervold, A., Lundervold, A. J., Maglanoc, L. A., Malt, U. F., Mecocci, P., Melle, I., Meyer-Lindenberg, A., Moberget, T., Norbom, L. B., Nordvik, J. E., Nyberg, L., Oosterlaan, J., Papalino, M., Papassotiropoulos, A., Pauli, P., Pergola, G., Persson, K., Richard, G., Rokicki, J., Sanders, A. -M., Selbaek, G., Shadrin, A. A., Smeland, O. B., Soininen, H., Sowa, P., Steen, V. M., Tsolaki, M., Ulrichsen, K. M., Vellas, B., Wang, L., Westman, E., Ziegler, G. C., Zink, M., Andreassen, O. A., Westlye, L. T., Le Hellard, S., Di Carlo, P., Interdisciplinary Centre Psychopathology and Emotion regulation (ICPE), Clinical Cognitive Neuropsychiatry Research Program (CCNP), General Paediatrics, ARD - Amsterdam Reproduction and Development, Pediatric surgery, Psychiatrie & Neuropsychologie, RS: MHeNs - R3 - Neuroscience, and RS: MHeNs - R2 - Mental Health

Subjects
0301 basic medicine, Brain age gap, brain disorders, genetic architecture, pleiotropy, Male, Aging, Schizophrenia/genetics, LOCI, Genome-wide association study, Neuropsychological Tests, 0302 clinical medicine, 80 and over, Brain age gap, Aging/genetics, ALZHEIMERS, Child, Aged, 80 and over, Brain Diseases, Sex Characteristics, General Neuroscience, Mental Disorders, Brain, MULTIPLE-SCLEROSIS, brain disorders, Middle Aged, Magnetic Resonance Imaging, 3. Good health, Schizophrenia, Child, Preschool, Female, Alzheimer's disease, Neurovetenskaper, Algorithms, MRI, Adult, Adolescent, Brain Diseases/diagnostic imaging, Brain Structure and Function, Mental Disorders/diagnostic imaging, Biology, Article, 03 medical and health sciences, Young Adult, AGE, pleiotropy, Genetic architecture, Genetic Pleiotropy, medicine, Humans, Preschool, Brain disorders, Aged, Pleiotropy, Neurodevelopmental disorders Donders Center for Medical Neuroscience [Radboudumc 7], Brain age gaps, Multiple sclerosis, Neurosciences, Infant, medicine.disease, Brain/diagnostic imaging, genetic architecture, 030104 developmental biology, Pleiotropy (drugs), Neuroscience, 030217 neurology & neurosurgery, Genome-Wide Association Study
Abstract

Common risk factors for psychiatric and other brain disorders are likely to converge on biological pathways influencing the development and maintenance of brain structure and function across life. Using structural MRI data from 45,615 individuals aged 3–96 years, we demonstrate distinct patterns of apparent brain aging in several brain disorders and reveal genetic pleiotropy between apparent brain aging in healthy individuals and common brain disorders. The author list between I.A. and M.Z. is in alphabetic order. The authors were funded by the Research Council of Norway (276082 LifespanHealth (T.K.), 213837 (O.A.A), 223273 NORMENT (O.A.A.), 204966 (L.T.W.), 229129 (O.A.A.), 249795 (L.T.W.), 273345 (L.T.W.) and 283798 SYNSCHIZ (O.A.A.)), the South-Eastern Norway Regional Health Authority (2013-123 (O.A.A.), 2014-097 (L.T.W.), 2015-073 (L.T.W.) and 2016083 (L.T.W.)), Stiftelsen Kristian Gerhard Jebsen (SKGJ-MED-008), the European Research Council (ERC) under the European Union’s Horizon 2020 research and innovation programme (ERC Starting Grant, Grant agreement No. 802998 BRAINMINT (L.T.W.)), NVIDIA Corporation GPU Grant (T.K.), and the European Commission 7th Framework Programme (602450, IMAGEMEND (A.M.-L.)).

Published
2019
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26. Characteristics of food allergy in children: National multicenter study

Author

Bingol, A., Uygun, Kocacik D. F., Akdemir, M., Erengin, H., Bozdogan, G., Bingol, G., Orhan, F., and Çukurova Üniversitesi

Abstract

Congress of the European-Academy-of-Allergy-and-Clinical-Immunology (EAACI) -- JUN 01-05, 2019 -- Lisbon, PORTUGAL WOS: 000480254003261 … European Acad Allergy & Clin Immunol

Published
2019

27. Reproducible grey matter patterns index a multivariate, global alteration of brain structure in schizophrenia and bipolar disorder

Author

Schwarz, E., Doan, N. T., Pergola, G., Westlye, L. T., Kaufmann, T., Wolfers, T., Brecheisen, R., Quarto, T., Ing, A. J., Di Carlo, P., Gurholt, T. P., Harms, R. L., Noirhomme, Q., Moberget, T., Agartz, I., Andreassen, O. A., Bellani, M., Bertolino, A., Blasi, G., Brambilla, P., Buitelaar, J. K., Cervenka, S., Flyckt, L., Frangou, S., Franke, B., Hall, J., Heslenfeld, D. J., Kirsch, P., Mcintosh, A. M., Nothen, M. M., Papassotiropoulos, A., de Quervain, D. J. -F., Rietschel, M., Schumann, G., Tost, H., Witt, S. H., Zink, M., Meyer-Lindenberg, A., Bettella, F., Brandt, C. L., Clarke, T. -K., Coynel, D., Degenhardt, F., Djurovic, S., Eisenacher, S., Fastenrath, M., Fatouros-Bergman, H., Forstner, A. J., Frank, J., Gambi, F., Gelao, B., Geschwind, L., Di Giannantonio, M., Di Giorgio, A., Hartman, C. A., Heilmann-Heimbach, S., Herms, S., Hoekstra, P. J., Hoffmann, P., Hoogman, M., Jonsson, E. G., Loos, E., Maggioni, E., Oosterlaan, J., Papalino, M., Rampino, A., Romaniuk, L., Selvaggi, P., Sepede, G., Sonderby, I. E., Spalek, K., Sussmann, J. E., Thompson, P. M., Vasquez, A. A., Vogler, C., Whalley, H., Farde, L., Engberg, G., Erhardt, S., Schwieler, L., Collste, K., Victorsson, P., Malmqvist, A., Hedberg, M., Orhan, F., Cognitive Psychology, IBBA, Behavioural Sciences, Elvira Brattico / Principal Investigator, Department of Psychology and Logopedics, Cognitive Brain Research Unit, Faculty of Medicine, University of Helsinki, General Paediatrics, ARD - Amsterdam Reproduction and Development, Interdisciplinary Centre Psychopathology and Emotion regulation (ICPE), Clinical Cognitive Neuropsychiatry Research Program (CCNP), Multiscale Imaging of Brain Connectivity, RS: FPN CN 11, Vision, and RS: FPN CN 1

Subjects
0301 basic medicine, Male, Multivariate statistics, Bipolar Disorder, SEGMENTATION, 3124 Neurology and psychiatry, Machine Learning, 0302 clinical medicine, DEFICITS, Gray Matter, Psychiatry, RISK, medicine.diagnostic_test, 220 Statistical Imaging Neuroscience, LIKELIHOOD ESTIMATION, Middle Aged, MRI SCANS, Magnetic Resonance Imaging, Justice and Strong Institutions, 3. Good health, Psychiatry and Mental health, medicine.anatomical_structure, bipolar disorders, Schizophrenia, Female, brain structural patterns, MRI, Adult, SDG 16 - Peace, Adolescent, Brain Structure and Function, Grey matter, Psykiatri, CLASSIFICATION, Article, lcsh:RC321-571, 03 medical and health sciences, Cellular and Molecular Neuroscience, Young Adult, Text mining, medicine, Humans, Bipolar disorder, lcsh:Neurosciences. Biological psychiatry. Neuropsychiatry, Biological Psychiatry, METAANALYSIS, schizophrenia, grey matter alterations, Neurodevelopmental disorders Donders Center for Medical Neuroscience [Radboudumc 7], business.industry, 1ST-EPISODE, SDG 16 - Peace, Justice and Strong Institutions, Magnetic resonance imaging, medicine.disease, 030104 developmental biology, Sample size determination, Attention Deficit Disorder with Hyperactivity, Case-Control Studies, VOLUME, business, Neuroscience, 030217 neurology & neurosurgery
Abstract

Contains fulltext : 202693.pdf (Publisher’s version ) (Open Access) Schizophrenia is a severe mental disorder characterized by numerous subtle changes in brain structure and function. Machine learning allows exploring the utility of combining structural and functional brain magnetic resonance imaging (MRI) measures for diagnostic application, but this approach has been hampered by sample size limitations and lack of differential diagnostic data. Here, we performed a multi-site machine learning analysis to explore brain structural patterns of T1 MRI data in 2668 individuals with schizophrenia, bipolar disorder or attention-deficit/ hyperactivity disorder, and healthy controls. We found reproducible changes of structural parameters in schizophrenia that yielded a classification accuracy of up to 76% and provided discrimination from ADHD, through it lacked specificity against bipolar disorder. The observed changes largely indexed distributed grey matter alterations that could be represented through a combination of several global brain-structural parameters. This multi-site machine learning study identified a brain-structural signature that could reproducibly differentiate schizophrenia patients from controls, but lacked specificity against bipolar disorder. While this currently limits the clinical utility of the identified signature, the present study highlights that the underlying alterations index substantial global grey matter changes in psychotic disorders, reflecting the biological similarity of these conditions, and provide a roadmap for future exploration of brain structural alterations in psychiatric patients.

Published
2019
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29. Reproducible grey matter patterns index a multivariate, global alteration of brain structure in schizophrenia and bipolar disorder

Author

Schwarz, Emanuel, Doan, Nhat Trung, Pergola, Giulio, Westlye, Lars T., Kaufmann, Tobias, Wolfers, Thomas, Brecheisen, Ralph, Quarto, Tiziana, Ing, Alex J., Di Carlo, Pasquale, Gurholt, Tiril P., Harms, Robbert L., Noirhomme, Quentin, Moberget, Torgeir, Agartz, Ingrid, Andreassen, Ole A., Bellani, Marcella, Bertolino, Alessandro, Blasi, Giuseppe, Brambilla, Paolo, Buitelaar, Jan K., Cervenka, Simon, Flyckt, Lena, Frangou, Sophia, Franke, Barbara, Hall, Jeremy, Heslenfeld, Dirk J., Kirsch, Peter, McIntosh, Andrew M., Noethen, Markus M., Papassotiropoulos, Andreas, de Quervain, Dominique J-F, Rietschel, Marcella, Schumann, Gunter, Tost, Heike, Witt, Stephanie H., Zink, Mathias, Meyer-Lindenberg, Andreas, Bettella, Francesco, Brandt, Christine L., Clarke, Toni-Kim, Coynel, David, Degenhardt, Franziska, Djurovic, Srdjan, Eisenacher, Sarah, Fastenrath, Matthias, Fatouros-Bergman, Helena, Forstner, Andreas J., Frank, Josef, Gambi, Francesco, Gelao, Barbara, Geschwind, Leo, Di Giannantonio, Massimo, Di Giorgio, Annabella, Hartman, Catharina A., Heilmann-Heimbach, Stefanie, Herms, Stefan, Hoekstra, Pieter J., Hoffmann, Per, Hoogman, Martine, Jonsson, Erik G., Loos, Eva, Maggioni, Eleonora, Oosterlaan, Jaap, Papalino, Marco, Rampino, Antonio, Romaniuk, Liana, Selvaggi, Pierluigi, Sepede, Gianna, Sonderby, Ida E., Spalek, Klara, Sussmann, Jessika E., Thompson, Paul M., Vasquez, Alejandro Arias, Vogler, Christian, Whalley, Heather, Farde, L., Flyckt, L., Engberg, G., Erhardt, S., Fatouros-Bergman, H., Cervenka, S., Schwieler, L., Agartz, I, Collste, K., Victorsson, P., Malmqvist, A., Hedberg, M., Orhan, F., Schwarz, Emanuel, Doan, Nhat Trung, Pergola, Giulio, Westlye, Lars T., Kaufmann, Tobias, Wolfers, Thomas, Brecheisen, Ralph, Quarto, Tiziana, Ing, Alex J., Di Carlo, Pasquale, Gurholt, Tiril P., Harms, Robbert L., Noirhomme, Quentin, Moberget, Torgeir, Agartz, Ingrid, Andreassen, Ole A., Bellani, Marcella, Bertolino, Alessandro, Blasi, Giuseppe, Brambilla, Paolo, Buitelaar, Jan K., Cervenka, Simon, Flyckt, Lena, Frangou, Sophia, Franke, Barbara, Hall, Jeremy, Heslenfeld, Dirk J., Kirsch, Peter, McIntosh, Andrew M., Noethen, Markus M., Papassotiropoulos, Andreas, de Quervain, Dominique J-F, Rietschel, Marcella, Schumann, Gunter, Tost, Heike, Witt, Stephanie H., Zink, Mathias, Meyer-Lindenberg, Andreas, Bettella, Francesco, Brandt, Christine L., Clarke, Toni-Kim, Coynel, David, Degenhardt, Franziska, Djurovic, Srdjan, Eisenacher, Sarah, Fastenrath, Matthias, Fatouros-Bergman, Helena, Forstner, Andreas J., Frank, Josef, Gambi, Francesco, Gelao, Barbara, Geschwind, Leo, Di Giannantonio, Massimo, Di Giorgio, Annabella, Hartman, Catharina A., Heilmann-Heimbach, Stefanie, Herms, Stefan, Hoekstra, Pieter J., Hoffmann, Per, Hoogman, Martine, Jonsson, Erik G., Loos, Eva, Maggioni, Eleonora, Oosterlaan, Jaap, Papalino, Marco, Rampino, Antonio, Romaniuk, Liana, Selvaggi, Pierluigi, Sepede, Gianna, Sonderby, Ida E., Spalek, Klara, Sussmann, Jessika E., Thompson, Paul M., Vasquez, Alejandro Arias, Vogler, Christian, Whalley, Heather, Farde, L., Flyckt, L., Engberg, G., Erhardt, S., Fatouros-Bergman, H., Cervenka, S., Schwieler, L., Agartz, I, Collste, K., Victorsson, P., Malmqvist, A., Hedberg, M., and Orhan, F.

Abstract

Schizophrenia is a severe mental disorder characterized by numerous subtle changes in brain structure and function. Machine learning allows exploring the utility of combining structural and functional brain magnetic resonance imaging (MRI) measures for diagnostic application, but this approach has been hampered by sample size limitations and lack of differential diagnostic data. Here, we performed a multi-site machine learning analysis to explore brain structural patterns of T1 MRI data in 2668 individuals with schizophrenia, bipolar disorder or attention-deficit/hyperactivity disorder, and healthy controls. We found reproducible changes of structural parameters in schizophrenia that yielded a classification accuracy of up to 76% and provided discrimination from ADHD, through it lacked specificity against bipolar disorder. The observed changes largely indexed distributed grey matter alterations that could be represented through a combination of several global brain-structural parameters. This multi-site machine learning study identified a brain-structural signature that could reproducibly differentiate schizophrenia patients from controls, but lacked specificity against bipolar disorder. While this currently limits the clinical utility of the identified signature, the present study highlights that the underlying alterations index substantial global grey matter changes in psychotic disorders, reflecting the biological similarity of these conditions, and provide a roadmap for future exploration of brain structural alterations in psychiatric patients.

Published
2019
Full Text
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30. Reply to: New Meta- and Mega-analyses of Magnetic Resonance Imaging Findings in Schizophrenia: Do They Really Increase Our Knowledge About the Nature of the Disease Process?

Author

van Erp, TGM, Walton, E, Hibar, DP, Schmaal, L, Jiang, W, Glahn, DC, Pearlson, GD, Yao, N, Fukunaga, M, Hashimoto, R, Okada, N, Yamamori, H, Clark, VP, Mueller, BA, de Zwarte, SMC, Ophoff, RA, van Haren, NEM, Andreassen, OA, Gurholt, TP, Gruber, O, Kraemer, B, Richter, A, Calhoun, VD, Crespo-Facorro, B, Roiz-Santiañez, R, Tordesillas-Gutiérrez, D, Loughland, C, Catts, S, Fullerton, JM, Green, MJ, Henskens, F, Jablensky, A, Mowry, BJ, Pantelis, C, Quidé, Y, Schall, U, Scott, RJ, Cairns, MJ, Seal, M, Tooney, PA, Rasser, PE, Cooper, G, Shannon Weickert, C, Weickert, TW, Hong, E, Kochunov, P, Gur, RE, Gur, RC, Ford, JM, Macciardi, F, Mathalon, DH, Potkin, SG, Preda, A, Fan, F, Ehrlich, S, King, MD, De Haan, L, Veltman, DJ, Assogna, F, Banaj, N, de Rossi, P, Iorio, M, Piras, F, Spalletta, G, Pomarol-Clotet, E, Kelly, S, Ciufolini, S, Radua, J, Murray, R, Marques, TR, Simmons, A, Borgwardt, S, Schönborn-Harrisberger, F, Riecher-Rössler, A, Smieskova, R, Alpert, KI, Bertolino, A, Bonvino, A, Di Giorgio, A, Neilson, E, Mayer, AR, Yun, JY, Cannon, DM, Lebedeva, I, Tomyshev, AS, Akhadov, T, Kaleda, V, Fatouros-Bergman, H, Flyckt, L, Farde, L, Cervenka, S, Agartz, I, Collste, K, Victorsson, P, Engberg, G, Erhardt, S, Schwieler, L, Malmqvist, A, Hedberg, M, Orhan, F, van Erp, TGM, Walton, E, Hibar, DP, Schmaal, L, Jiang, W, Glahn, DC, Pearlson, GD, Yao, N, Fukunaga, M, Hashimoto, R, Okada, N, Yamamori, H, Clark, VP, Mueller, BA, de Zwarte, SMC, Ophoff, RA, van Haren, NEM, Andreassen, OA, Gurholt, TP, Gruber, O, Kraemer, B, Richter, A, Calhoun, VD, Crespo-Facorro, B, Roiz-Santiañez, R, Tordesillas-Gutiérrez, D, Loughland, C, Catts, S, Fullerton, JM, Green, MJ, Henskens, F, Jablensky, A, Mowry, BJ, Pantelis, C, Quidé, Y, Schall, U, Scott, RJ, Cairns, MJ, Seal, M, Tooney, PA, Rasser, PE, Cooper, G, Shannon Weickert, C, Weickert, TW, Hong, E, Kochunov, P, Gur, RE, Gur, RC, Ford, JM, Macciardi, F, Mathalon, DH, Potkin, SG, Preda, A, Fan, F, Ehrlich, S, King, MD, De Haan, L, Veltman, DJ, Assogna, F, Banaj, N, de Rossi, P, Iorio, M, Piras, F, Spalletta, G, Pomarol-Clotet, E, Kelly, S, Ciufolini, S, Radua, J, Murray, R, Marques, TR, Simmons, A, Borgwardt, S, Schönborn-Harrisberger, F, Riecher-Rössler, A, Smieskova, R, Alpert, KI, Bertolino, A, Bonvino, A, Di Giorgio, A, Neilson, E, Mayer, AR, Yun, JY, Cannon, DM, Lebedeva, I, Tomyshev, AS, Akhadov, T, Kaleda, V, Fatouros-Bergman, H, Flyckt, L, Farde, L, Cervenka, S, Agartz, I, Collste, K, Victorsson, P, Engberg, G, Erhardt, S, Schwieler, L, Malmqvist, A, Hedberg, M, and Orhan, F

Published
2019

31. Neurogranin as a potential synaptic marker in the cerebrospinal fluid of patients with a first episode psychosis

Author

Santillo, A. F., Lundgren, S., Xu, C., Orhan, F., Fatouros-Bergman, H., Blennow, K., Zetterberg, H., Portelius, E., Cervenka, Simon, Jonsson, E. G., Erhardt, S., Engberg, G., Santillo, A. F., Lundgren, S., Xu, C., Orhan, F., Fatouros-Bergman, H., Blennow, K., Zetterberg, H., Portelius, E., Cervenka, Simon, Jonsson, E. G., Erhardt, S., and Engberg, G.

Published
2019
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32. Increased peripheral levels of TARC/CCL17 in first episode psychosis patients

Author

Malmqvist, Anna, Schwieler, Lilly, Orhan, Funda, Fatouros-Bergman, Helena, Bauer, Markus, Flyckt, Lena, Cervenka, Simon, Engberg, Goran, Piehl, Fredrik, Erhardt, Sophie, Farde, L., Flyckt, L., Engberg, G., Erhardt, S., Fatouros-Bergman, H., Cervenka, S., Schwieler, L., Piehl, F., Agartz, I, Collste, K., Victorsson, P., Malmqvist, A., Hedberg, M., Orhan, F., Malmqvist, Anna, Schwieler, Lilly, Orhan, Funda, Fatouros-Bergman, Helena, Bauer, Markus, Flyckt, Lena, Cervenka, Simon, Engberg, Goran, Piehl, Fredrik, Erhardt, Sophie, Farde, L., Flyckt, L., Engberg, G., Erhardt, S., Fatouros-Bergman, H., Cervenka, S., Schwieler, L., Piehl, F., Agartz, I, Collste, K., Victorsson, P., Malmqvist, A., Hedberg, M., and Orhan, F.

Abstract

Background: Evidence for a link between the pathophysiology of schizophrenia and the immune system is mounting. Altered levels of chemokines in plasma have previously been reported in patients with schizophrenia under antipsychotic medication. Here we aimed to study both peripheral and central chemokine levels in drugnaive or short-time medicated first episode psychosis (FEP) patients. Method: We analyzed nine chemokines in plasma and CSF from 41 FEP patients and 22 healthy controls using electrochemiluminescence assay. Results: In plasma four chemokines; TARC/CCL17, eotaxin/CCL11, MDC/CCL22, IP-10/CXCL10 and in CSF one chemokine; IP-10/CXCL10 showed reliable detection in N50% of the cases. FEP patients displayed increased levels of TARC/CCL17 in plasma compared to healthy controls, 89.6 (IQR 66.2-125.8) pg/mL compared to 48.6 (IQR 28.0-71.7) pg/mL (p = 0.001). The difference was not attributed to confounding factors. Plasma TARC/CCL17 was not associated with PANSS, CGI or GAF scores, neither with cognitive functions. The chemokines eotaxin/CCL11, MDC/CCL22, IP-10/CXCL10 in plasma and IP-10/CXCL10 in CSF did not differ between FEP patients and controls. Conclusion: In line with a previous study showing that chronic patients with schizophrenia display increased plasma TARC/CCL17 levels, we here found an elevation in FEP patients suggesting a role of TARC/CCL17 in early stages of schizophrenia. The exactmechanism of this involvement is still unknown and future longitudinal studies as well as studies of central and peripheral chemokine levels would be of great interest. (C) 2018 Elsevier B.V. All rights reserved.

Published
2019
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36. Cerebrospinal fluid levels of sphingolipids associate with disease severity in first episode psychosis patients

Author

Farde, L., Flyckt, L., Engberg, G., Erhardt, S., Fatouros-Bergman, H., Cervenka, S., Schwieler, L., Piehl, F., Agartz, I., Collste, K., Victorsson, P., Malmqvist, A., Hedberg, M., Orhan, F., Checa, Antonio, Malmqvist, Anna, Flyckt, Lena, Schwieler, Lilly, Samuelsson, Martin, Skogh, Elisabeth, Cervenka, Simon, Dahl, Marja-Liisa, Piehl, Fredrik, Erhardt, Sophie, and Wheelock, Craig E.

Published
2018
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38. Anti-mutagenic and anti-oxidant potencies of Cetraria aculeata (Schreb.) Fr., Cladonia chlorophaea (Flörke ex sommerf.) spreng. and Cetrelia olivetorum (Nyl.) W.L. Culb. & C.F. Culb.)

Author

Ceker S., Orhan F., Sezen S., Gulluce M., Ozkan H., Aslan A., Agar G., and Belirlenecek

Subjects
Short term tests (Ames-Salmonella, E. coli-WP2, SCE), food and beverages, Anti-mutagenicity, Anti-oxidant, Lichen extracts
Abstract

In this study, the mutagenic and anti-mutagenic effects of methanol extract of three lichen species (Cetraria aculeata, Cladonia chlorophaea and Cetrelia olivetorum) were investigated by using E. coli-WP2, Ames-Salmonella (TA1535 and TA1537) and sister chromatid exchange (SCE) test systems. The results obtained from bacterial test systems demonstrated that methanol extracts of three lichen species have strong anti-mutagenic potencies on TA1535, TA1537 strains and to a lesser extent on E. coli-WP2 strain. The anti-oxidant level of human lymphocytes cells was determined in order to clarify the mechanism underlying the anti-mutagenic effects of these lichen species. Co-treatments of 5, 10 and 20 µg/mL concentrations of these three lichen species with AFB decreased the frequencies of SCE and the level of MDA and increased the amount of SOD, GSH and GPx which decreased by aflatoxin. The findings of this work have clearly demonstrated that Cetraria aculeata, Cladonia chlorophaea and Cetrelia olivetorum have significant anti-mutagenic effects which are thought to be partly due to the anti-oxidant activities and the interaction capability of lichen extracts with mutagen agents (Sodium azide, acridin, N-methyl-N?-nitro-N-nitrosoguanidine and aflatoxin B1). © 2018 by School of Pharmacy Shaheed Beheshti University of Medical Sciences and Health Services.

Published
2018

39. P311 Clinical features of cystic fibrosis patients with chronic liver disease in the Turkish National Cystic Fibrosis Registry

Author

Sismanlar Eyuboglu, T., primary, Dogru Ersoz, D., additional, Cakır, E., additional, Cobanoglu, N., additional, Pekcan, S., additional, Cinel, G., additional, Yalcın, E., additional, Kiper, N., additional, Sen, V., additional, Selimoglu Sen, H., additional, Ercan, O., additional, Keskin, O., additional, Bilgic Eltan, S., additional, Muhammed Al Shadfan, L., additional, Yazan, H., additional, Altıntas, D.U., additional, Sasihuseyinoglu, S., additional, Sapan, N., additional, Cekic, S., additional, Cokugras, H., additional, Kılınc, A.A., additional, Ramaslı Gursoy, T., additional, Aslan, A.T., additional, Bingol, A., additional, Basaran, A.E., additional, Ozdemir, A., additional, Kose, M., additional, Hangul, M., additional, Emiralioglu, N., additional, Tugcu, G., additional, Yuksel, H., additional, Yılmaz, O., additional, Orhan, F., additional, Gayretli Aydın, Z.G., additional, Topal, E., additional, Tamay, Z., additional, Suleyman, A., additional, Can, D., additional, Bal, C.M., additional, Caltepe, G., additional, and Ozcelik, U., additional

Published
2019
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40. P323 Pseudo Bartter Syndrome: the most common complication in the Turkish National Cystic Fibrosis Registry

Author

Sismanlar Eyuboglu, T., primary, Doğru Ersoz, D., additional, Cakır, E., additional, Cobanoglu, N., additional, Pekcan, S., additional, Cinel, G., additional, Yalcın, E., additional, Kiper, N., additional, Sen, V., additional, Selimoglu Sen, H., additional, Ercan, O., additional, Keskin, O., additional, Bilgic Eltan, S., additional, Muhammed Al Shadfan, L., additional, Yazan, H., additional, Altıntas, D.U., additional, Sasihuseyinoglu, S., additional, Sapan, N., additional, Cekic, S., additional, Cokugras, H., additional, Kılınc, A.A., additional, Ramaslı Gursoy, T., additional, Aslan, A.T., additional, Bingol, A., additional, Basaran, A.E., additional, Ozdemir, A., additional, Kose, M., additional, Hangul, M., additional, Emiralioglu, N., additional, Tugcu, G., additional, Yuksel, H., additional, Yılmaz, O., additional, Orhan, F., additional, Gayretli Aydın, Z.G., additional, Topal, E., additional, Tamay, Z., additional, Suleyman, A., additional, Can, D., additional, Bal, C.M., additional, Caltepe, G., additional, and Ozcelik, U., additional

Published
2019
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41. P059 First results of Turkish National Cystic Fibrosis Registry

Author

Doğru Ersöz, D., primary, Çakır, E., additional, Şişmanlar Eyüboğlu, T., additional, Çobanoğlu, N., additional, Pekcan, S., additional, Cinel, G., additional, Yalçın, E., additional, Kiper, N., additional, Şen, V., additional, Selimoğlu Şen, H., additional, Ercan, Ö., additional, Keskin, Ö., additional, Bilgiç Eltan, S., additional, Muhammed Al Shadfan, L., additional, Yazan, H., additional, Altıntaş, D.U., additional, Şaşihüseyinoğlu, Ş., additional, Sapan, N., additional, Çekiç, Ş., additional, Çokuğraş, H., additional, Ayzıt Atabek, A., additional, Ramaslı Gürsoy, T., additional, Aslan, A.T., additional, Bingöl, A., additional, Başaran, A.E., additional, Özdemir, A., additional, Köse, M., additional, Hangül, M., additional, Emiralioğlu, N., additional, Tuğcu, G., additional, Yüksel, H., additional, Yılmaz, Ö., additional, Orhan, F., additional, Gayretli Aydın, Z.G., additional, Topal, E., additional, Tamay, Z., additional, Süleyman, A., additional, Can, D., additional, Bal, C.M., additional, Çaltepe, G., additional, and Özçelik, U., additional

Published
2019
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44. CSF GABA is reduced in first-episode psychosis and associates to symptom severity

Author

Orhan, F, Fatouros-Bergman, H, Goiny, M, Malmqvist, A, Piehl, F, Cervenka, Simon, Collste, K, Victorsson, P, Sellgren, C M, Flyckt, L, Erhardt, S, Engberg, G, Orhan, F, Fatouros-Bergman, H, Goiny, M, Malmqvist, A, Piehl, F, Cervenka, Simon, Collste, K, Victorsson, P, Sellgren, C M, Flyckt, L, Erhardt, S, and Engberg, G

Abstract

Schizophrenia is characterized by a multiplicity of symptoms arising from almost all domains of mental function. γ-Aminobutyric acid (GABA) is the primary inhibitory neurotransmitter in the brain and is increasingly recognized to have a significant role in the pathophysiology of the disorder. In the present study, cerebrospinal fluid (CSF) concentrations of GABA were analyzed in 41 first-episode psychosis (FEP) patients and 21 age- and sex-matched healthy volunteers by high-performance liquid chromatography. We found lower CSF GABA concentration in FEP patients compared with that in the healthy volunteers, a condition that was unrelated to antipsychotic and/or anxiolytic medication. Moreover, lower CSF GABA levels were associated with total and general score of Positive and Negative Syndrome Scale, illness severity and probably with a poor performance in a test of attention. This study offers clinical in vivo evidence for a potential role of GABA in early-stage schizophrenia.

Published
2018
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45. Cortical Brain Abnormalities in 4474 Individuals With Schizophrenia and 5098 Control Subjects via the Enhancing Neuro Imaging Genetics Through Meta Analysis (ENIGMA) Consortium

Author

Erp, T.G.M. (Theo G.) van, Walton, E. (Esther), Hibar, D.P. (Derrek P.), Schmaal, L. (Lianne), Jiang, W. (Wenhao), Glahn, D.C. (David), Pearlson, G. (Godfrey), Yao, N. (Nailin), Fukunaga, M. (Masaki), Hashimoto, R. (Ryota), Okada, N. (Naohiro), Yamamori, H. (Hidenaga), Bustillo, J., Clark, V.P., Agartz, I. (Ingrid), Mueller, B.A. (Bryon ), Cahn, W. (Wiepke), de Zwarte, S.M.C. (Sonja M.C.), Hulshoff Pol, H.E. (Hilleke), Kahn, R. (René), Ophoff, R.A. (Roel), van Haren, N.E.M. (Neeltje E.M.), Andreassen, O.A. (Ole), Dale, A.M. (Anders), Doan, N.T. (Nhat Trung), Gurholt, T.P. (Tiril P.), Hartberg, C.B. (Cecilie B.), Haukvik, U.K. (Unn), Jørgensen, K.N. (Kjetil N.), Lagerberg, T.V. (Trine V.), Melle, I. (Ingrid), Westlye, L.T. (Lars), Gruber, O. (Oliver), Kraemer, B. (Bernd), Richter, A. (Anja), Zilles, D. (David), Calhoun, V.D. (Vince), Crespo-Facorro, B. (Benedicto), Roiz-Santiañez, R. (Roberto), Tordesillas-Gutierrez, D. (Diana), Loughland, C.M. (Carmel), Carr, V.J. (Vaughan J.), Catts, S.V. (Stanley), Cropley, V.L. (Vanessa L.), Fullerton, J.M. (Janice M.), Green, M.J. (Melissa J.), Henskens, F.A. (Frans), Jablensky, A. (Assen), Lenroot, R.K. (Rhoshel), Mowry, B.J. (Bryan J), Michie, P.T. (Patricia), Pantelis, C. (Christos), Quidé, Y. (Yann), Schall, J.D. (Jeffrey), Scott, R.J. (Rodney J.), Cairns, M.J. (Murray J.), Seal, M. (Marc), Tooney, P.A. (Paul A.), Rasser, P.E. (Paul E.), Cooper, G. (Gavin), Shannon Weickert, C. (Cynthia), Weickert, T.W. (Thomas W.), Morris, D.W. (Derek W), Hong, E. (Elliot), Kochunov, P. (Peter), Beard, L.M. (Lauren M.), Gur, R.E. (Raquel), Gur, R.C. (Ruben C.), Satterthwaite, T.D. (Theodore), Wolf, D.H. (Daniel H.), Belger, A. (Aysenil), Brown, G.G. (Gregory G.), Ford, J.M. (Judith M.), Macciardi, F. (Fabio), Mathalon, D.H. (Daniel H.), O'Leary, D.S. (Daniel S.), Potkin, S.G. (Steven), Preda, A. (Adrian), Voyvodic, J. (James), Lim, K.O. (Kelvin), McEwen, S. (Sarah), Yang, F. (Fude), Tan, Y. (Yunlong), Tan, S. (Shuping), Wang, Z. (Zhiren), Fan, F. (Fengmei), Chen, J. (Jingxu), Xiang, H. (Hong), Tang, S. (Shiyou), Guo, H. (Hua), Wan, P. (Ping), Wei, D. (Dong), Bockholt, H.J., Ehrlich, S.M. (Stefan), Wolthusen, R.P.F. (Rick P.F.), King, M.D. (Margaret D.), Shoemaker, J.M. (Jody M.), Sponheim, S.R. (Scott), Haan, L. (Lieuwe) de, Koenders, L. (Laura), Machielsen, M.W.J. (Marise), Amelsvoort, T.A.M.J. (Therese) van, Veltman, D.J. (Dick), Assogna, F. (Francesca), Banaj, N. (Nerisa), de Rossi, P. (Pietro), Iorio, M. (Mariangela), Piras, F. (Fabrizio), Spalletta, G. (Gianfranco), McKenna, P.J. (Peter J.), Pomarol-Clotet, E. (Edith), Salvador, R. (Raymond), Corvin, A. (Aiden), Donohoe, D.J. (Dennis), Kelly, S. (Sinead), Whelan, C.D. (Christopher), Dickie, E.W. (Erin W.), Rotenberg, D. (David), Voineskos, A.N. (Aristotle N.), Ciufolini, S. (Simone), Radua, J. (Joaquim), Dazzan, P. (Paola), Murray, R. (Robin), Reis Marques, T. (Tiago), Simmons, A. (Andrew), Borgwardt, S. (Stefan), Egloff, L. (Laura), Harrisberger, F. (Fabienne), Riecher-Rössler, A. (Anita), Smieskova, R. (Renata), Alpert, K. (Kathryn), Wang, L. (Lei), Jönsson, E.G. (Erik), Koops, S. (Sanne), Sommer, I.E.C. (Iris E.C.), Bertolino, A. (Alessandro), Bonvino, A. (Aurora), Di Giorgio, A. (Annabella), Neilson, E. (Emma), Mayer, A.R. (Andrew R.), Stephen, J.M. (Julia M.), Kwon, J.S. (Jun Soo), Yun, J.-Y. (Je-Yeon), Cannon, D.M. (Dara), McDonald, C. (Colm), Lebedeva, I. (Irina), Tomyshev, A.S. (Alexander S.), Akhadov, T. (Tolibjohn), Kaleda, V. (Vasily), Fatouros-Bergman, H. (Helena), Flyckt, L. (Lena), Farde, L. (Lars), Engberg, G. (Göran), Erhardt, S. (Sophie), Cervenka, S. (Simon), Schwieler, L. (Lilly), Piehl, F. (Fredrik), Collste, K. (Karin), Victorsson, P. (Pauliina), Malmqvist, A. (Anna), Hedberg, M. (Mikael), Orhan, F. (Funda), Busatto, G.F. (Geraldo F.), Rosa, P.G.P. (Pedro G.P.), Serpa, M.H. (Mauricio H.), Zanetti, M.V. (Marcus V.), Hoschl, C. (Cyril), Skoch, A. (Antonin), Spaniel, F. (Filip), Tomecek, D. (David), Hagenaars, S. (Saskia), McIntosh, A.M. (Andrew), Whalley, H.C. (Heather C.), Lawrie, S. (Stephen), Knöchel, C. (Christian), Oertel-Knöchel, V. (Viola), Stäblein, M. (Michael), Howells, F.M. (Fleur M.), Stein, D.J. (Dan), Temmingh, H.S. (Henk S.), Uhlmann, A. (Anne), Lopez-Jaramillo, C. (Carlos), Dima, D. (Danai), McMahon, A. (Agnes), Faskowitz, J.I. (Joshua I.), Gutman, B.A. (Boris A.), Jahanshad, N. (Neda), Thompson, P.M. (Paul), Turner, J. (Jessica), Erp, T.G.M. (Theo G.) van, Walton, E. (Esther), Hibar, D.P. (Derrek P.), Schmaal, L. (Lianne), Jiang, W. (Wenhao), Glahn, D.C. (David), Pearlson, G. (Godfrey), Yao, N. (Nailin), Fukunaga, M. (Masaki), Hashimoto, R. (Ryota), Okada, N. (Naohiro), Yamamori, H. (Hidenaga), Bustillo, J., Clark, V.P., Agartz, I. (Ingrid), Mueller, B.A. (Bryon ), Cahn, W. (Wiepke), de Zwarte, S.M.C. (Sonja M.C.), Hulshoff Pol, H.E. (Hilleke), Kahn, R. (René), Ophoff, R.A. (Roel), van Haren, N.E.M. (Neeltje E.M.), Andreassen, O.A. (Ole), Dale, A.M. (Anders), Doan, N.T. (Nhat Trung), Gurholt, T.P. (Tiril P.), Hartberg, C.B. (Cecilie B.), Haukvik, U.K. (Unn), Jørgensen, K.N. (Kjetil N.), Lagerberg, T.V. (Trine V.), Melle, I. (Ingrid), Westlye, L.T. (Lars), Gruber, O. (Oliver), Kraemer, B. (Bernd), Richter, A. (Anja), Zilles, D. (David), Calhoun, V.D. (Vince), Crespo-Facorro, B. (Benedicto), Roiz-Santiañez, R. (Roberto), Tordesillas-Gutierrez, D. (Diana), Loughland, C.M. (Carmel), Carr, V.J. (Vaughan J.), Catts, S.V. (Stanley), Cropley, V.L. (Vanessa L.), Fullerton, J.M. (Janice M.), Green, M.J. (Melissa J.), Henskens, F.A. (Frans), Jablensky, A. (Assen), Lenroot, R.K. (Rhoshel), Mowry, B.J. (Bryan J), Michie, P.T. (Patricia), Pantelis, C. (Christos), Quidé, Y. (Yann), Schall, J.D. (Jeffrey), Scott, R.J. (Rodney J.), Cairns, M.J. (Murray J.), Seal, M. (Marc), Tooney, P.A. (Paul A.), Rasser, P.E. (Paul E.), Cooper, G. (Gavin), Shannon Weickert, C. (Cynthia), Weickert, T.W. (Thomas W.), Morris, D.W. (Derek W), Hong, E. (Elliot), Kochunov, P. (Peter), Beard, L.M. (Lauren M.), Gur, R.E. (Raquel), Gur, R.C. (Ruben C.), Satterthwaite, T.D. (Theodore), Wolf, D.H. (Daniel H.), Belger, A. (Aysenil), Brown, G.G. (Gregory G.), Ford, J.M. (Judith M.), Macciardi, F. (Fabio), Mathalon, D.H. (Daniel H.), O'Leary, D.S. (Daniel S.), Potkin, S.G. (Steven), Preda, A. (Adrian), Voyvodic, J. (James), Lim, K.O. (Kelvin), McEwen, S. (Sarah), Yang, F. (Fude), Tan, Y. (Yunlong), Tan, S. (Shuping), Wang, Z. (Zhiren), Fan, F. (Fengmei), Chen, J. (Jingxu), Xiang, H. (Hong), Tang, S. (Shiyou), Guo, H. (Hua), Wan, P. (Ping), Wei, D. (Dong), Bockholt, H.J., Ehrlich, S.M. (Stefan), Wolthusen, R.P.F. (Rick P.F.), King, M.D. (Margaret D.), Shoemaker, J.M. (Jody M.), Sponheim, S.R. (Scott), Haan, L. (Lieuwe) de, Koenders, L. (Laura), Machielsen, M.W.J. (Marise), Amelsvoort, T.A.M.J. (Therese) van, Veltman, D.J. (Dick), Assogna, F. (Francesca), Banaj, N. (Nerisa), de Rossi, P. (Pietro), Iorio, M. (Mariangela), Piras, F. (Fabrizio), Spalletta, G. (Gianfranco), McKenna, P.J. (Peter J.), Pomarol-Clotet, E. (Edith), Salvador, R. (Raymond), Corvin, A. (Aiden), Donohoe, D.J. (Dennis), Kelly, S. (Sinead), Whelan, C.D. (Christopher), Dickie, E.W. (Erin W.), Rotenberg, D. (David), Voineskos, A.N. (Aristotle N.), Ciufolini, S. (Simone), Radua, J. (Joaquim), Dazzan, P. (Paola), Murray, R. (Robin), Reis Marques, T. (Tiago), Simmons, A. (Andrew), Borgwardt, S. (Stefan), Egloff, L. (Laura), Harrisberger, F. (Fabienne), Riecher-Rössler, A. (Anita), Smieskova, R. (Renata), Alpert, K. (Kathryn), Wang, L. (Lei), Jönsson, E.G. (Erik), Koops, S. (Sanne), Sommer, I.E.C. (Iris E.C.), Bertolino, A. (Alessandro), Bonvino, A. (Aurora), Di Giorgio, A. (Annabella), Neilson, E. (Emma), Mayer, A.R. (Andrew R.), Stephen, J.M. (Julia M.), Kwon, J.S. (Jun Soo), Yun, J.-Y. (Je-Yeon), Cannon, D.M. (Dara), McDonald, C. (Colm), Lebedeva, I. (Irina), Tomyshev, A.S. (Alexander S.), Akhadov, T. (Tolibjohn), Kaleda, V. (Vasily), Fatouros-Bergman, H. (Helena), Flyckt, L. (Lena), Farde, L. (Lars), Engberg, G. (Göran), Erhardt, S. (Sophie), Cervenka, S. (Simon), Schwieler, L. (Lilly), Piehl, F. (Fredrik), Collste, K. (Karin), Victorsson, P. (Pauliina), Malmqvist, A. (Anna), Hedberg, M. (Mikael), Orhan, F. (Funda), Busatto, G.F. (Geraldo F.), Rosa, P.G.P. (Pedro G.P.), Serpa, M.H. (Mauricio H.), Zanetti, M.V. (Marcus V.), Hoschl, C. (Cyril), Skoch, A. (Antonin), Spaniel, F. (Filip), Tomecek, D. (David), Hagenaars, S. (Saskia), McIntosh, A.M. (Andrew), Whalley, H.C. (Heather C.), Lawrie, S. (Stephen), Knöchel, C. (Christian), Oertel-Knöchel, V. (Viola), Stäblein, M. (Michael), Howells, F.M. (Fleur M.), Stein, D.J. (Dan), Temmingh, H.S. (Henk S.), Uhlmann, A. (Anne), Lopez-Jaramillo, C. (Carlos), Dima, D. (Danai), McMahon, A. (Agnes), Faskowitz, J.I. (Joshua I.), Gutman, B.A. (Boris A.), Jahanshad, N. (Neda), Thompson, P.M. (Paul), and Turner, J. (Jessica)

Abstract

Background: The profile of cortical neuroanatomical abnormalities in schizophrenia is not fully understood, despite hundreds of published structural brain imaging studies. This

Published
2018
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46. Increased number of monocytes and plasma levels of MCP-1 and YKL-40 in first-episode psychosis

Author

Orhan, F., Schwieler, L., Fatouros-Bergman, H., Malmqvist, A., Cervenka, Simon, Collste, K., Flyckt, L., Farde, L., Sellgren, C. M., Piehl, F., Engberg, G., Erhardt, S., Orhan, F., Schwieler, L., Fatouros-Bergman, H., Malmqvist, A., Cervenka, Simon, Collste, K., Flyckt, L., Farde, L., Sellgren, C. M., Piehl, F., Engberg, G., and Erhardt, S.

Abstract

ObjectiveMethodAccumulating evidence implicates immune activation in the development of schizophrenia. Here, monocyte numbers, monocyte chemoattractant protein-1 (MCP-1) and chitinase-3-like protein 1 (YKL-40) were investigated in plasma and cerebrospinal fluid (CSF) in first-episode psychosis (FEP) patients. CSF and blood were sampled from 42 first-episode psychosis (FEP) patients and 22 healthy controls. The levels of YKL-40 and MCP-1 were measured using electrochemiluminescence assay, and blood monocytes were counted using an XN-9000-hematology analyzer. ResultsConclusionWe found higher plasma levels of MCP-1 and YKL-40 in FEP patients compared with healthy controls, a condition that was unrelated to antipsychotic and/or anxiolytic medication. This was combined with an increased number of blood monocytes and a borderline significant increase in YKL-40 levels in the CSF of tobacco-free FEP patients. Plasma or CSF chemokines or blood monocytes did not correlate with the severity of symptoms or the level of functioning. These data demonstrate activation of monocytes in FEP and strengthens the idea of an immune dysfunction of psychotic disorders. Further studies are required to perceive a role of YKL-40 and MCP-1 in the initiation and progression of schizophrenia.

Published
2018
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47. Positive symptoms associate with cortical thinning in the superior temporal gyrus via the enigma schizophrenia consortium

Author

Walton, E., Hibar, D. P., van Erp, T. G M, Potkin, S. G., Roiz-Santiañez, R., Crespo-Facorro, B., Suarez-Pinilla, P., Van Haren, N. E M, de Zwarte, S. M C, Kahn, R. S., Cahn, W., Doan, N. T., Jørgensen, K. N., Gurholt, T. P., Agartz, I., Andreassen, O. A., Westlye, L. T., Melle, I., Berg, A. O., Mørch-Johnsen, L., Færden, A., Flyckt, L., Fatouros-Bergman, H., Jönsson, E. G., Hashimoto, R., Yamamori, H., Fukunaga, M., Preda, A., De Rossi, P., Piras, F., Banaj, N., Ciullo, V., Spalletta, G., Gur, R. E., Gur, R. C., Wolf, D. H., Satterthwaite, T. D., Beard, L. M., Sommer, I. E., Koops, S., Gruber, O., Richter, A., Krämer, B., Kelly, S., Donohoe, G., McDonald, C., Cannon, D. M., Corvin, A., Gill, M., Di Giorgio, A., Bertolino, A., Lawrie, S., Nickson, T., Whalley, H. C., Neilson, E., Calhoun, V. D., Thompson, P. M., Turner, J. A., Ehrlich, S., Farde, L., Engberg, G., Erhardt, S., Cervenka, S., Schwieler, L., Piehl, F., Ikonen, P., Collste, K., Orhan, F., Malmqvist, A., and Hedberg, M.

Subjects
Male, genetic structures, Planum temporale, FreeSurfer, Audiology, Brain mapping, Superior temporal gyrus, 0302 clinical medicine, enigma, Prospective Studies, psychosis, bipolar disorder, Brain Mapping, Positive and Negative Syndrome Scale, positive and negative syndrome scale, ENIGMA, Magnetic Resonance Imaging, Temporal Lobe, Multicenter Study, Psychiatry and Mental health, superior temporal gyrus, Schizophrenia, cerebral-cortex, Female, Schizophrenic Psychology, auditory verbal hallucinations, Psychology, comprehension, MRI, freesurfer, metaanalysis, Adult, medicine.medical_specialty, Psychosis, cortical thickness, positive symptoms, scale for the assessment of positive symptoms, schizophrenia, Humans, Psychiatric Status Rating Scales, Psychiatry and Mental Health, 1st-episode schizophrenia, behavioral disciplines and activities, Article, Temporal lobe, 03 medical and health sciences, Journal Article, medicine, Bipolar disorder, Psychiatry, mri, medicine.disease, thickness, 030227 psychiatry, planum temporale, 1st episode schizophrenia, 030217 neurology & neurosurgery, Meta-Analysis
Abstract

OBJECTIVE: Based on the role of the superior temporal gyrus (STG) in auditory processing, language comprehension and self-monitoring, this study aimed to investigate the relationship between STG cortical thickness and positive symptom severity in schizophrenia.METHOD: This prospective meta-analysis includes data from 1987 individuals with schizophrenia collected at seventeen centres around the world that contribute to the ENIGMA Schizophrenia Working Group. STG thickness measures were extracted from T1-weighted brain scans using FreeSurfer. The study performed a meta-analysis of effect sizes across sites generated by a model predicting left or right STG thickness with a positive symptom severity score (harmonized SAPS or PANSS-positive scores), while controlling for age, sex and site. Secondary models investigated relationships between antipsychotic medication, duration of illness, overall illness severity, handedness and STG thickness.RESULTS: Positive symptom severity was negatively related to STG thickness in both hemispheres (left: βstd = -0.052; P = 0.021; right: βstd = -0.073; P = 0.001) when statistically controlling for age, sex and site. This effect remained stable in models including duration of illness, antipsychotic medication or handedness.CONCLUSION: Our findings further underline the important role of the STG in hallmark symptoms in schizophrenia. These findings can assist in advancing insight into symptom-relevant pathophysiological mechanisms in schizophrenia.

Published
2017
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48. Cerebrospinal fluid levels of sphingolipids associate with disease severity in first episode psychosis patients

Author

Checa, Antonio, primary, Malmqvist, Anna, additional, Flyckt, Lena, additional, Schwieler, Lilly, additional, Samuelsson, Martin, additional, Skogh, Elisabeth, additional, Cervenka, Simon, additional, Dahl, Marja-Liisa, additional, Piehl, Fredrik, additional, Erhardt, Sophie, additional, Wheelock, Craig E., additional, Farde, L., additional, Flyckt, L., additional, Engberg, G., additional, Erhardt, S., additional, Fatouros-Bergman, H., additional, Cervenka, S., additional, Schwieler, L., additional, Piehl, F., additional, Agartz, I., additional, Collste, K., additional, Victorsson, P., additional, Malmqvist, A., additional, Hedberg, M., additional, and Orhan, F., additional

Published
2018
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50. Positive symptoms associate with cortical thinning in the superior temporal gyrus via the ENIGMA Schizophrenia consortium

Author

Onderzoeksgroep 4, Brain, Onderzoeksgroep 11, Affectieve & Psychotische Med., Curr. Onderwijs Huisartsgeneeskunde, Affectieve & Psychotisch Ond., Risico & Preventie Ond., Walton, E., Hibar, D. P., van Erp, T. G M, Potkin, S. G., Roiz-Santiañez, R., Crespo-Facorro, B., Suarez-Pinilla, P., Van Haren, N. E M, de Zwarte, S. M C, Kahn, R. S., Cahn, W., Doan, N. T., Jørgensen, K. N., Gurholt, T. P., Agartz, I., Andreassen, O. A., Westlye, L. T., Melle, I., Berg, A. O., Mørch-Johnsen, L., Færden, A., Flyckt, L., Fatouros-Bergman, H., Jönsson, E. G., Hashimoto, R., Yamamori, H., Fukunaga, M., Preda, A., De Rossi, P., Piras, F., Banaj, N., Ciullo, V., Spalletta, G., Gur, R. E., Gur, R. C., Wolf, D. H., Satterthwaite, T. D., Beard, L. M., Sommer, I. E., Koops, S., Gruber, O., Richter, A., Krämer, B., Kelly, S., Donohoe, G., McDonald, C., Cannon, D. M., Corvin, A., Gill, M., Di Giorgio, A., Bertolino, A., Lawrie, S., Nickson, T., Whalley, H. C., Neilson, E., Calhoun, V. D., Thompson, P. M., Turner, J. A., Ehrlich, S., Farde, L., Engberg, G., Erhardt, S., Cervenka, S., Schwieler, L., Piehl, F., Ikonen, P., Collste, K., Orhan, F., Malmqvist, A., Hedberg, M., Onderzoeksgroep 4, Brain, Onderzoeksgroep 11, Affectieve & Psychotische Med., Curr. Onderwijs Huisartsgeneeskunde, Affectieve & Psychotisch Ond., Risico & Preventie Ond., Walton, E., Hibar, D. P., van Erp, T. G M, Potkin, S. G., Roiz-Santiañez, R., Crespo-Facorro, B., Suarez-Pinilla, P., Van Haren, N. E M, de Zwarte, S. M C, Kahn, R. S., Cahn, W., Doan, N. T., Jørgensen, K. N., Gurholt, T. P., Agartz, I., Andreassen, O. A., Westlye, L. T., Melle, I., Berg, A. O., Mørch-Johnsen, L., Færden, A., Flyckt, L., Fatouros-Bergman, H., Jönsson, E. G., Hashimoto, R., Yamamori, H., Fukunaga, M., Preda, A., De Rossi, P., Piras, F., Banaj, N., Ciullo, V., Spalletta, G., Gur, R. E., Gur, R. C., Wolf, D. H., Satterthwaite, T. D., Beard, L. M., Sommer, I. E., Koops, S., Gruber, O., Richter, A., Krämer, B., Kelly, S., Donohoe, G., McDonald, C., Cannon, D. M., Corvin, A., Gill, M., Di Giorgio, A., Bertolino, A., Lawrie, S., Nickson, T., Whalley, H. C., Neilson, E., Calhoun, V. D., Thompson, P. M., Turner, J. A., Ehrlich, S., Farde, L., Engberg, G., Erhardt, S., Cervenka, S., Schwieler, L., Piehl, F., Ikonen, P., Collste, K., Orhan, F., Malmqvist, A., and Hedberg, M.

Published
2017

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